ZBTB49

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)9.41793869
2negative regulation of axon guidance (GO:1902668)8.79296448
3localization within membrane (GO:0051668)8.78735330
4pore complex assembly (GO:0046931)8.75664132
5protein localization to microtubule (GO:0035372)8.22733588
6positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)7.71852683
7synapsis (GO:0007129)7.66504786
8epithelial cell differentiation involved in kidney development (GO:0035850)7.27135914
9protein complex localization (GO:0031503)7.26214493
10positive regulation of membrane protein ectodomain proteolysis (GO:0051044)7.23410508
11positive regulation of ERBB signaling pathway (GO:1901186)7.22516077
12positive regulation of microtubule polymerization (GO:0031116)7.17861073
13positive regulation of pseudopodium assembly (GO:0031274)7.16737081
14cytoplasmic microtubule organization (GO:0031122)7.02819687
15regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)6.92960994
16regulation of axon guidance (GO:1902667)6.82861833
17eye photoreceptor cell differentiation (GO:0001754)6.82539683
18photoreceptor cell differentiation (GO:0046530)6.82539683
19regulation of pseudopodium assembly (GO:0031272)6.33252480
20regulation of glomerular filtration (GO:0003093)6.15869668
21regulation of attachment of spindle microtubules to kinetochore (GO:0051988)6.06406515
22interkinetic nuclear migration (GO:0022027)5.95044648
23ionotropic glutamate receptor signaling pathway (GO:0035235)5.80533418
24regulation of membrane protein ectodomain proteolysis (GO:0051043)5.61819290
25piRNA metabolic process (GO:0034587)5.36021583
26regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)5.34533214
27RNA localization (GO:0006403)5.11692017
28glomerulus development (GO:0032835)5.11015620
29renal system process involved in regulation of blood volume (GO:0001977)5.02624284
30regulation of sensory perception of pain (GO:0051930)4.96871232
31regulation of sensory perception (GO:0051931)4.96871232
32negative regulation of glycogen metabolic process (GO:0070874)4.94388726
33positive regulation of microtubule polymerization or depolymerization (GO:0031112)4.92518529
34regulation of nuclear cell cycle DNA replication (GO:0033262)4.65441781
35synaptic transmission, glutamatergic (GO:0035249)4.59830003
36regulation of helicase activity (GO:0051095)4.51497926
37stem cell division (GO:0017145)4.44516386
38G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.39989803
39axonemal dynein complex assembly (GO:0070286)4.37509927
40regulation of DNA methylation (GO:0044030)4.37198122
41regulation of meiosis I (GO:0060631)4.33064381
42negative regulation of chemotaxis (GO:0050922)4.30924160
43positive regulation of humoral immune response (GO:0002922)4.28273628
44DNA methylation involved in gamete generation (GO:0043046)4.25854077
45monocyte chemotaxis (GO:0002548)4.25051522
46neuromuscular junction development (GO:0007528)4.21406932
47renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)4.17425974
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.16574631
49muscle cell cellular homeostasis (GO:0046716)4.13135258
50behavioral response to cocaine (GO:0048148)3.86095387
51synaptic vesicle endocytosis (GO:0048488)3.81312066
52negative regulation of heart rate (GO:0010459)3.80915944
53glutamate receptor signaling pathway (GO:0007215)3.75911107
54N-terminal protein amino acid acetylation (GO:0006474)3.74000543
55meiotic cell cycle (GO:0051321)3.70288616
56negative regulation of cell killing (GO:0031342)3.67674507
57negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.67674507
58apoptotic DNA fragmentation (GO:0006309)3.67244690
59negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)3.65814367
60protein localization to microtubule cytoskeleton (GO:0072698)3.64672290
61positive regulation of small GTPase mediated signal transduction (GO:0051057)3.63776593
62regulation of microtubule polymerization (GO:0031113)3.62422134
63ganglion development (GO:0061548)3.60223736
64multicellular organism reproduction (GO:0032504)3.58172900
65histone H3-K4 methylation (GO:0051568)3.57254796
66axon extension involved in axon guidance (GO:0048846)3.52669142
67neuron projection extension involved in neuron projection guidance (GO:1902284)3.52669142
68positive regulation of gamma-delta T cell activation (GO:0046645)3.52117223
69regulation of histone H3-K9 methylation (GO:0051570)3.51866630
70cell differentiation involved in kidney development (GO:0061005)3.50393235
71regulation of B cell receptor signaling pathway (GO:0050855)3.49808948
72positive regulation of histone deacetylation (GO:0031065)3.48500262
73proximal/distal pattern formation (GO:0009954)3.42816825
74regulation of female gonad development (GO:2000194)3.42167552
75modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.41097517
76positive regulation by organism of defense response of other organism involved in symbiotic interact3.41097517
77modulation by symbiont of host immune response (GO:0052553)3.41097517
78positive regulation by symbiont of host defense response (GO:0052509)3.41097517
79modulation by symbiont of host defense response (GO:0052031)3.41097517
80modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.41097517
81epithelial cilium movement (GO:0003351)3.40427278
82RNA destabilization (GO:0050779)3.37929238
83negative regulation of histone methylation (GO:0031061)3.37701747
84negative regulation of axon extension involved in axon guidance (GO:0048843)3.35452434
85mesonephros development (GO:0001823)3.34639674
86germ cell migration (GO:0008354)3.33215559
87seminiferous tubule development (GO:0072520)3.32092873
88ribonucleoprotein complex disassembly (GO:0032988)3.31836894
89negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.30504448
90regulation of axon extension involved in axon guidance (GO:0048841)3.30364142
91positive regulation of histone H3-K4 methylation (GO:0051571)3.29512687
92regulation of cell communication by electrical coupling (GO:0010649)3.24006168
93histone H3-K4 trimethylation (GO:0080182)3.23419162
94regulation of relaxation of muscle (GO:1901077)3.22209127
95oocyte development (GO:0048599)3.19581129
96positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.18622786
97regulation of telomere maintenance (GO:0032204)3.18046105
98dendritic cell chemotaxis (GO:0002407)3.17289836
99positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.16386223
100negative regulation of defense response to virus (GO:0050687)3.13284325
101neuron-neuron synaptic transmission (GO:0007270)3.09635974
102activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.08648079
103protein localization to cytoskeleton (GO:0044380)3.08004427
104retinal cone cell development (GO:0046549)3.05551198
105attachment of spindle microtubules to kinetochore (GO:0008608)3.03607953
106positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.01017250
107macrophage activation involved in immune response (GO:0002281)2.98701973
108negative regulation of epidermal cell differentiation (GO:0045605)2.97883324
109Sertoli cell development (GO:0060009)2.97314178
110positive regulation of glycogen metabolic process (GO:0070875)2.94553242
111regulation of acrosome reaction (GO:0060046)2.93304439
112organelle membrane fusion (GO:0090174)2.93118496
113adrenergic receptor signaling pathway (GO:0071875)2.92819586
114positive regulation of toll-like receptor signaling pathway (GO:0034123)2.92799129
115positive regulation of DNA recombination (GO:0045911)2.91765131
116facial nerve structural organization (GO:0021612)2.87903359
117peptidyl-lysine trimethylation (GO:0018023)2.86624771
118DNA alkylation (GO:0006305)2.86266628
119DNA methylation (GO:0006306)2.86266628
120leukocyte aggregation (GO:0070486)2.85638588
121synaptic vesicle maturation (GO:0016188)2.84785021
122centriole replication (GO:0007099)2.83658868
123negative regulation of behavior (GO:0048521)2.82396571
124regulation of interleukin-12 biosynthetic process (GO:0045075)2.77858226
125regulation of interferon-beta biosynthetic process (GO:0045357)2.75942072
126positive regulation of isotype switching (GO:0045830)2.74722179
127male meiosis I (GO:0007141)2.73579814
128cilium or flagellum-dependent cell motility (GO:0001539)2.72849384
129negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.72656712
130myelin maintenance (GO:0043217)2.70981276
131regulation of cardiac muscle cell contraction (GO:0086004)2.70954423
132aerobic respiration (GO:0009060)2.70310423
133NIK/NF-kappaB signaling (GO:0038061)2.69121534
134organ growth (GO:0035265)2.66999013
135organelle disassembly (GO:1903008)2.65255632
136positive regulation of oligodendrocyte differentiation (GO:0048714)2.64801278
137negative regulation of interleukin-12 production (GO:0032695)2.64743149
138cullin deneddylation (GO:0010388)2.64663333
139regulation of double-strand break repair via homologous recombination (GO:0010569)2.64515295
140pyrimidine-containing compound transmembrane transport (GO:0072531)2.63761088
141positive regulation of DNA-dependent DNA replication (GO:2000105)2.63479551
142interferon-gamma production (GO:0032609)2.63425077
143regulation of somitogenesis (GO:0014807)2.62600339
144positive regulation of granulocyte differentiation (GO:0030854)2.60101476
145protein K6-linked ubiquitination (GO:0085020)2.60085326
146gene silencing by RNA (GO:0031047)2.57576165
147negative regulation of microtubule depolymerization (GO:0007026)2.55218737
148negative regulation of T cell mediated immunity (GO:0002710)2.54497100
149sequestering of metal ion (GO:0051238)2.53709921
150DNA double-strand break processing (GO:0000729)2.52762069
151protein deneddylation (GO:0000338)2.52685959
152positive regulation of interferon-beta production (GO:0032728)2.51453830
153neutrophil mediated immunity (GO:0002446)2.50641395
154negative regulation of lymphocyte mediated immunity (GO:0002707)2.50628996
155synaptic vesicle docking involved in exocytosis (GO:0016081)2.50598832
156behavioral response to nicotine (GO:0035095)2.50026242
157meiosis I (GO:0007127)2.49249484
158type I interferon signaling pathway (GO:0060337)2.49192860
159cellular response to type I interferon (GO:0071357)2.49192860
160regulation of short-term neuronal synaptic plasticity (GO:0048172)2.49008128
161male meiosis (GO:0007140)2.48790759
162protein kinase C signaling (GO:0070528)2.48784611
163negative regulation of histone modification (GO:0031057)2.46616566
164spliceosomal tri-snRNP complex assembly (GO:0000244)2.46282914
165regulation of gamma-delta T cell activation (GO:0046643)2.44660788
166detection of molecule of bacterial origin (GO:0032490)2.42736579
167T cell migration (GO:0072678)2.42429119
168positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.42376222
169negative regulation of cAMP-mediated signaling (GO:0043951)2.42280845
170negative regulation of DNA-templated transcription, elongation (GO:0032785)2.39449166
171neutrophil activation (GO:0042119)2.39430895
172regulation of mitotic spindle checkpoint (GO:1903504)2.38699757
173regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.38699757
174protein localization to chromosome (GO:0034502)2.38222746
175histone H3-K36 demethylation (GO:0070544)2.37865149
176cellular response to interleukin-15 (GO:0071350)2.36658297
177response to type I interferon (GO:0034340)2.36202289
178regulation of interleukin-1 beta secretion (GO:0050706)2.36066554
179maintenance of protein location in nucleus (GO:0051457)2.35981915
180neutrophil activation involved in immune response (GO:0002283)2.35159195
181DNA methylation or demethylation (GO:0044728)2.33417873
182positive regulation of interleukin-1 beta secretion (GO:0050718)2.32899172
183positive regulation of histone methylation (GO:0031062)2.32344926
184regulation of histone H3-K4 methylation (GO:0051569)2.31406731
185leukocyte migration involved in inflammatory response (GO:0002523)2.31036754
186tolerance induction (GO:0002507)2.30883505
187regulation of interferon-beta production (GO:0032648)2.30039225
188glycine transport (GO:0015816)2.29863701
189regulation of isotype switching (GO:0045191)2.29720511
190binding of sperm to zona pellucida (GO:0007339)2.29657239
191response to host immune response (GO:0052572)2.28238818
192response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.28238818
193meiotic nuclear division (GO:0007126)2.28154749
194regulation of hypersensitivity (GO:0002883)2.27975781
195nuclear pore complex assembly (GO:0051292)11.3888816
196startle response (GO:0001964)10.2949188
197cellular protein complex localization (GO:0034629)10.1242314

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.33342295
2CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons5.28234869
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.17738773
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.98200132
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.48767654
6NOTCH1_21737748_ChIP-Seq_TLL_Human3.15332405
7ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse3.12071814
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.11728722
9GBX2_23144817_ChIP-Seq_PC3_Human2.96043974
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.90656335
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.85267128
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.72843510
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.72589043
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.61684288
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.57968732
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.57692059
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.57016630
18RUNX1_17652178_ChIP-ChIP_JURKAT_Human2.49702343
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.48919279
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.34729436
21E2F7_22180533_ChIP-Seq_HELA_Human2.34308634
22* VDR_23849224_ChIP-Seq_CD4+_Human2.31744262
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.25625086
24MYB_26560356_Chip-Seq_TH2_Human2.25042247
25RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.23932686
26GABP_17652178_ChIP-ChIP_JURKAT_Human2.20604183
27JARID2_20064375_ChIP-Seq_MESCs_Mouse2.17391291
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15119844
29GATA1_26923725_Chip-Seq_HPCs_Mouse2.12635256
30TAF15_26573619_Chip-Seq_HEK293_Human2.12158220
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.09692589
32E2F4_17652178_ChIP-ChIP_JURKAT_Human2.09286729
33EST1_17652178_ChIP-ChIP_JURKAT_Human2.08671894
34SPI1_23547873_ChIP-Seq_NB4_Human2.06471112
35FOXM1_23109430_ChIP-Seq_U2OS_Human2.04096309
36FOXP3_21729870_ChIP-Seq_TREG_Human2.03949301
37SRY_22984422_ChIP-ChIP_TESTIS_Rat2.03569918
38MYB_26560356_Chip-Seq_TH1_Human1.99052563
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.97982703
40IRF8_27001747_Chip-Seq_BMDM_Mouse1.94352153
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93108477
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85262405
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.84885267
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.84885267
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84816082
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.84598102
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84102930
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.81031266
49P53_22127205_ChIP-Seq_FIBROBLAST_Human1.80478069
50SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.80354894
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79948904
52SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78062788
53CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77077979
54DROSHA_22980978_ChIP-Seq_HELA_Human1.74855565
55IRF8_21731497_ChIP-ChIP_J774_Mouse1.72824011
56RARB_27405468_Chip-Seq_BRAIN_Mouse1.71754165
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.70938083
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68968060
59NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68397767
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64545661
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62982190
62KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.62641213
63KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.62641213
64KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.62641213
65JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62444158
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.62276790
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62205747
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60823596
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60734009
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.57940471
71* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57912277
72CIITA_25753668_ChIP-Seq_RAJI_Human1.53747945
73ZNF274_21170338_ChIP-Seq_K562_Hela1.51289131
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.50282308
75ETS1_20019798_ChIP-Seq_JURKAT_Human1.50055111
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48900783
77MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47999157
78MTF2_20144788_ChIP-Seq_MESCs_Mouse1.47300824
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47124715
80SCL_19346495_ChIP-Seq_HPC-7_Human1.46973278
81MAF_26560356_Chip-Seq_TH1_Human1.46716427
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46489780
83ELK1_19687146_ChIP-ChIP_HELA_Human1.45007039
84CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44469782
85KDM2B_26808549_Chip-Seq_JURKAT_Human1.44354837
86SMAD3_21741376_ChIP-Seq_HESCs_Human1.43156446
87TP63_19390658_ChIP-ChIP_HaCaT_Human1.43022950
88GATA3_26560356_Chip-Seq_TH2_Human1.41904864
89UTX_26944678_Chip-Seq_JUKART_Human1.41623343
90GATA3_27048872_Chip-Seq_THYMUS_Human1.41501250
91PRDM14_20953172_ChIP-Seq_ESCs_Human1.41159920
92SALL1_21062744_ChIP-ChIP_HESCs_Human1.40993985
93FLI1_27457419_Chip-Seq_LIVER_Mouse1.40883466
94BCAT_22108803_ChIP-Seq_LS180_Human1.40451004
95* REST_21632747_ChIP-Seq_MESCs_Mouse1.40080355
96IRF1_19129219_ChIP-ChIP_H3396_Human1.39015339
97SMAD_19615063_ChIP-ChIP_OVARY_Human1.35933282
98GABP_19822575_ChIP-Seq_HepG2_Human1.34484786
99MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.34067725
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.32812013
101HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31582596
102CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30628742
103STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.30549147
104TFEB_21752829_ChIP-Seq_HELA_Human1.29579004
105SOX2_21211035_ChIP-Seq_LN229_Gbm1.28682720
106* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.28582166
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28520245
108DCP1A_22483619_ChIP-Seq_HELA_Human1.28237135
109ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.27859553
110MYC_22102868_ChIP-Seq_BL_Human1.27770596
111MAF_26560356_Chip-Seq_TH2_Human1.27500496
112STAT1_20625510_ChIP-Seq_HELA_Human1.25436507
113YY1_21170310_ChIP-Seq_MESCs_Mouse1.24794306
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.23787701
115PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23374351
116SMAD4_21741376_ChIP-Seq_HESCs_Human1.22864788
117RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22499269
118SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21070810
119EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20869885
120RUNX1_22412390_ChIP-Seq_EML_Mouse1.20152205
121SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19974172
122ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18783195
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18644811
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18644811
125POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17667084
126FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16276339
127SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.14742962
128BP1_19119308_ChIP-ChIP_Hs578T_Human1.14026867
129SPI1_23127762_ChIP-Seq_K562_Human1.13312119
130IGF1R_20145208_ChIP-Seq_DFB_Human1.13248944
131MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13167398
132RNF2_27304074_Chip-Seq_ESCs_Mouse1.12821151
133E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12294003
134JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12015554
135TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11614065
136VDR_24787735_ChIP-Seq_THP-1_Human1.10996448
137PIAS1_25552417_ChIP-Seq_VCAP_Human1.10430968
138IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10207595
139TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08891697
140ER_23166858_ChIP-Seq_MCF-7_Human1.07776822
141E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07345541
142PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06779442
143KDM5A_27292631_Chip-Seq_BREAST_Human1.06777612
144WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06465375
145SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.06164499
146NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04907519
147GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02596076
148POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01622965
149SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01240439
150SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00482807
151ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00459771
152BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00356120
153CDX2_20551321_ChIP-Seq_CACO-2_Human0.99566737
154PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98015911
155EGR1_19374776_ChIP-ChIP_THP-1_Human0.97380403
156STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97321609
157HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.96961634
158Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96772093
159NANOG_16518401_ChIP-PET_MESCs_Mouse0.96540421
160AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96301265
161STAT3_23295773_ChIP-Seq_U87_Human0.95911089
162VDR_21846776_ChIP-Seq_THP-1_Human0.95576429
163ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94792602
164CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94704998
165NELFA_20434984_ChIP-Seq_ESCs_Mouse0.93856587
166CMYC_18555785_Chip-Seq_ESCs_Mouse0.93698427
167SRF_21415370_ChIP-Seq_HL-1_Mouse0.93591978
168TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92930841
169TAL1_26923725_Chip-Seq_HPCs_Mouse0.92564993
170CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.92551485
171SMRT_27268052_Chip-Seq_Bcells_Human0.92468253
172MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90293241
173TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90213221
174SMAD4_21741376_ChIP-Seq_EPCs_Human0.89738171
175SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89610088
176ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89572730
177ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88890567
178RUNX_20019798_ChIP-Seq_JUKART_Human0.87588841
179EZH2_27304074_Chip-Seq_ESCs_Mouse0.87528460
180RING1B_27294783_Chip-Seq_NPCs_Mouse0.87443979
181BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.85385888
182NFE2_27457419_Chip-Seq_LIVER_Mouse0.85236292
183PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.85070422
184CTCF_18555785_Chip-Seq_ESCs_Mouse0.84510487
185RUNX1_27514584_Chip-Seq_MCF-7_Human0.83562966
186RUNX1_26923725_Chip-Seq_HPCs_Mouse0.82888810
187NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.82687805
188TCF4_23295773_ChIP-Seq_U87_Human0.81482075
189E2F1_18555785_Chip-Seq_ESCs_Mouse0.81389611
190AR_25329375_ChIP-Seq_VCAP_Human0.80480466
191YAP1_20516196_ChIP-Seq_MESCs_Mouse0.80400019
192RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.79710808
193ISL1_27105846_Chip-Seq_CPCs_Mouse0.78330788
194TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.77741318
195RUNX2_22187159_ChIP-Seq_PCA_Human0.77695308

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation6.93895986
2MP0005248_abnormal_Harderian_gland5.52761862
3MP0003787_abnormal_imprinting4.79085154
4MP0010352_gastrointestinal_tract_polyps4.78829256
5MP0010386_abnormal_urinary_bladder4.66623609
6MP0000465_gastrointestinal_hemorrhage4.56692529
7MP0008877_abnormal_DNA_methylation4.50082665
8MP0002909_abnormal_adrenal_gland4.48671934
9MP0005187_abnormal_penis_morphology4.02144424
10MP0003868_abnormal_feces_composition3.56393628
11MP0002396_abnormal_hematopoietic_system3.37840916
12MP0003718_maternal_effect3.23720595
13MP0003724_increased_susceptibility_to3.13369756
14MP0002127_abnormal_cardiovascular_syste2.66876528
15MP0004133_heterotaxia2.65212399
16MP0000462_abnormal_digestive_system2.58034440
17MP0005671_abnormal_response_to2.55884359
18MP0003436_decreased_susceptibility_to2.48906667
19MP0004134_abnormal_chest_morphology2.46356210
20MP0008057_abnormal_DNA_replication2.35728514
21MP0008789_abnormal_olfactory_epithelium2.34759641
22MP0008058_abnormal_DNA_repair2.33382617
23MP0009785_altered_susceptibility_to2.32798735
24MP0005394_taste/olfaction_phenotype2.29358781
25MP0005499_abnormal_olfactory_system2.29358781
26MP0001835_abnormal_antigen_presentation2.28859422
27MP0000647_abnormal_sebaceous_gland2.21250210
28MP0002419_abnormal_innate_immunity2.21225313
29MP0001800_abnormal_humoral_immune2.21022375
30MP0003763_abnormal_thymus_physiology2.20675189
31MP0005000_abnormal_immune_tolerance2.14681686
32MP0002723_abnormal_immune_serum2.10625756
33MP0002452_abnormal_antigen_presenting2.07327535
34MP0008260_abnormal_autophagy2.05444729
35MP0002420_abnormal_adaptive_immunity2.04596726
36MP0001819_abnormal_immune_cell2.02171265
37MP0000538_abnormal_urinary_bladder1.95003855
38MP0005025_abnormal_response_to1.94487915
39MP0005085_abnormal_gallbladder_physiolo1.88193215
40MP0003880_abnormal_central_pattern1.85210662
41MP0001919_abnormal_reproductive_system1.83383014
42MP0002405_respiratory_system_inflammati1.82560976
43MP0003693_abnormal_embryo_hatching1.81280141
44MP0003111_abnormal_nucleus_morphology1.77694964
45MP0001545_abnormal_hematopoietic_system1.76351025
46MP0005397_hematopoietic_system_phenotyp1.76351025
47MP0002398_abnormal_bone_marrow1.76071500
48MP0006082_CNS_inflammation1.73490204
49MP0002148_abnormal_hypersensitivity_rea1.72492915
50MP0004270_analgesia1.71811665
51MP0009333_abnormal_splenocyte_physiolog1.66562948
52MP0003077_abnormal_cell_cycle1.65892746
53MP0009672_abnormal_birth_weight1.65198987
54MP0000613_abnormal_salivary_gland1.63607226
55MP0000920_abnormal_myelination1.62028193
56MP0000716_abnormal_immune_system1.59137562
57MP0010094_abnormal_chromosome_stability1.56613083
58MP0006276_abnormal_autonomic_nervous1.52550326
59MP0005387_immune_system_phenotype1.52052250
60MP0001790_abnormal_immune_system1.52052250
61MP0000689_abnormal_spleen_morphology1.51580685
62MP0002722_abnormal_immune_system1.49691143
63MP0010307_abnormal_tumor_latency1.49608779
64MP0004858_abnormal_nervous_system1.49418588
65MP0002095_abnormal_skin_pigmentation1.46741285
66MP0003191_abnormal_cellular_cholesterol1.46506388
67MP0003786_premature_aging1.45407851
68MP0002139_abnormal_hepatobiliary_system1.42471113
69MP0004859_abnormal_synaptic_plasticity1.41433406
70MP0000703_abnormal_thymus_morphology1.41302195
71MP0001664_abnormal_digestion1.39936895
72MP0003879_abnormal_hair_cell1.39501077
73MP0001929_abnormal_gametogenesis1.35778771
74MP0003941_abnormal_skin_development1.34236659
75MP0005395_other_phenotype1.32059806
76MP0003656_abnormal_erythrocyte_physiolo1.30046951
77MP0003699_abnormal_female_reproductive1.27042013
78MP0002429_abnormal_blood_cell1.27028788
79MP0002653_abnormal_ependyma_morphology1.25251384
80MP0003121_genomic_imprinting1.24123669
81MP0009745_abnormal_behavioral_response1.22679814
82MP0003119_abnormal_digestive_system1.21649037
83MP0000685_abnormal_immune_system1.17393680
84MP0009764_decreased_sensitivity_to1.17033775
85MP0002063_abnormal_learning/memory/cond1.16926481
86MP0001845_abnormal_inflammatory_respons1.16675084
87MP0010155_abnormal_intestine_physiology1.13504170
88MP0003635_abnormal_synaptic_transmissio1.13469839
89MP0009703_decreased_birth_body1.12035520
90MP0001663_abnormal_digestive_system1.09338580
91MP0002132_abnormal_respiratory_system1.09227396
92MP0006292_abnormal_olfactory_placode1.08614954
93MP0002102_abnormal_ear_morphology1.08397300
94MP0001533_abnormal_skeleton_physiology1.07864603
95MP0002210_abnormal_sex_determination1.07242258
96MP0000569_abnormal_digit_pigmentation1.02281274
97MP0002234_abnormal_pharynx_morphology1.01550528
98MP0001119_abnormal_female_reproductive1.01352506
99MP0003942_abnormal_urinary_system1.00392707
100MP0002019_abnormal_tumor_incidence0.99749762
101MP0001486_abnormal_startle_reflex0.99364190
102MP0001243_abnormal_dermal_layer0.98876667
103MP0008469_abnormal_protein_level0.98334664
104MP0005310_abnormal_salivary_gland0.97233116
105MP0004142_abnormal_muscle_tone0.96097089
106MP0004808_abnormal_hematopoietic_stem0.95787977
107MP0009840_abnormal_foam_cell0.95577999
108MP0006035_abnormal_mitochondrial_morpho0.95122311
109MP0008932_abnormal_embryonic_tissue0.94927992
110MP0003937_abnormal_limbs/digits/tail_de0.92785810
111MP0002254_reproductive_system_inflammat0.92236929
112MP0005423_abnormal_somatic_nervous0.90874685
113MP0000653_abnormal_sex_gland0.90126082
114MP0005389_reproductive_system_phenotype0.89701795
115MP0002177_abnormal_outer_ear0.89005709
116MP0003385_abnormal_body_wall0.88419797
117MP0002277_abnormal_respiratory_mucosa0.87669351
118MP0009278_abnormal_bone_marrow0.86231372
119MP0003705_abnormal_hypodermis_morpholog0.85965622
120MP0005464_abnormal_platelet_physiology0.85163900
121MP0005595_abnormal_vascular_smooth0.83383322
122MP0002064_seizures0.83248981
123MP0009765_abnormal_xenobiotic_induced0.82428445
124MP0003221_abnormal_cardiomyocyte_apopto0.82082004
125MP0002161_abnormal_fertility/fecundity0.81440748
126MP0000639_abnormal_adrenal_gland0.80551534
127MP0003195_calcinosis0.80382795
128MP0005381_digestive/alimentary_phenotyp0.80191841
129MP0004947_skin_inflammation0.80122458
130MP0005076_abnormal_cell_differentiation0.79661750
131MP0000249_abnormal_blood_vessel0.77225017
132MP0002557_abnormal_social/conspecific_i0.77120256
133MP0002272_abnormal_nervous_system0.76918414
134MP0003866_abnormal_defecation0.76759217
135MP0000313_abnormal_cell_death0.76094553
136MP0003698_abnormal_male_reproductive0.74808046
137MP0001730_embryonic_growth_arrest0.74386248
138MP0009250_abnormal_appendicular_skeleto0.73976980
139MP0008007_abnormal_cellular_replicative0.73366698
140MP0005075_abnormal_melanosome_morpholog0.72651341
141MP0005058_abnormal_lysosome_morphology0.72347072
142MP0000427_abnormal_hair_cycle0.72305013
143MP0001873_stomach_inflammation0.72077836
144MP0002184_abnormal_innervation0.71712990
145MP0000470_abnormal_stomach_morphology0.71455949
146MP0005647_abnormal_sex_gland0.70189640
147MP0002098_abnormal_vibrissa_morphology0.69676093
148MP0001145_abnormal_male_reproductive0.67899492
149MP0002928_abnormal_bile_duct0.67079331
150MP0002896_abnormal_bone_mineralization0.66636469
151MP0002152_abnormal_brain_morphology0.66625307
152MP0008995_early_reproductive_senescence0.66042682
153MP0000631_abnormal_neuroendocrine_gland0.65969749
154MP0002998_abnormal_bone_remodeling0.65153833
155MP0000858_altered_metastatic_potential0.64807472
156MP0000579_abnormal_nail_morphology0.64496842
157MP0001853_heart_inflammation0.64437389
158MP0001851_eye_inflammation0.63951131
159MP0003329_amyloid_beta_deposits0.63258992
160MP0002971_abnormal_brown_adipose0.63253953
161MP0001984_abnormal_olfaction0.63193508
162MP0002111_abnormal_tail_morphology0.62844555
163MP0004957_abnormal_blastocyst_morpholog0.62579294
164MP0002067_abnormal_sensory_capabilities0.62477931
165MP0000490_abnormal_crypts_of0.62344345
166MP0005551_abnormal_eye_electrophysiolog0.62034091
167MP0005384_cellular_phenotype0.61517096
168MP0001905_abnormal_dopamine_level0.60462568
169MP0005646_abnormal_pituitary_gland0.60183274
170MP0002693_abnormal_pancreas_physiology0.60076443
171MP0002882_abnormal_neuron_morphology0.59166458
172MP0005666_abnormal_adipose_tissue0.55581017
173MP0002066_abnormal_motor_capabilities/c0.54883552
174MP0004085_abnormal_heartbeat0.54016582
175MP0010329_abnormal_lipoprotein_level0.53831828
176MP0002572_abnormal_emotion/affect_behav0.52010228
177MP0003283_abnormal_digestive_organ0.51693525
178MP0000428_abnormal_craniofacial_morphol0.50961555
179MP0000762_abnormal_tongue_morphology0.50235526
180MP0002736_abnormal_nociception_after0.50120520
181MP0005386_behavior/neurological_phenoty0.50069362
182MP0004924_abnormal_behavior0.50069362
183MP0005360_urolithiasis0.49651363
184MP0003755_abnormal_palate_morphology0.47511345
185MP0005670_abnormal_white_adipose0.47010062
186MP0003115_abnormal_respiratory_system0.46580285
187MP0001501_abnormal_sleep_pattern0.46126472
188MP0005451_abnormal_body_composition0.45988072
189MP0005171_absent_coat_pigmentation0.43579530

Predicted human phenotypes

RankGene SetZ-score
1Curly hair (HP:0002212)7.65937446
2High anterior hairline (HP:0009890)7.39910478
3Neoplasm of the adrenal cortex (HP:0100641)7.12194830
4Hepatoblastoma (HP:0002884)6.74221080
5Hypochromic microcytic anemia (HP:0004840)6.51860004
6Back pain (HP:0003418)6.36360713
7Stomach cancer (HP:0012126)6.31409359
8Volvulus (HP:0002580)5.99483250
9Aplasia/Hypoplasia of the sacrum (HP:0008517)5.89728181
10Colon cancer (HP:0003003)5.88023303
11Wide intermamillary distance (HP:0006610)5.49001682
12Epidermoid cyst (HP:0200040)5.43025723
13Subacute progressive viral hepatitis (HP:0006572)5.40601182
14Blue irides (HP:0000635)5.34873483
15Depressed nasal tip (HP:0000437)5.31736070
16Abnormal umbilical cord blood vessels (HP:0011403)5.27651761
17Single umbilical artery (HP:0001195)5.27651761
18Abnormality of the fetal cardiovascular system (HP:0010948)5.27651761
19Bell-shaped thorax (HP:0001591)5.24026044
20Prolonged bleeding time (HP:0003010)4.84958047
21Optic neuritis (HP:0100653)4.72208617
22Retrobulbar optic neuritis (HP:0100654)4.72208617
23Orchitis (HP:0100796)4.34701549
24Cubitus valgus (HP:0002967)4.12786307
25Fibroma (HP:0010614)4.12164198
26Myositis (HP:0100614)4.05398781
27Stomatitis (HP:0010280)4.02461640
28Abnormality of the astrocytes (HP:0100707)4.01726748
29Astrocytoma (HP:0009592)4.01726748
30Fibrous tissue neoplasm (HP:0012316)3.94030679
31Papillary thyroid carcinoma (HP:0002895)3.86772208
32Cystic hygroma (HP:0000476)3.84228117
33Absent frontal sinuses (HP:0002688)3.77244705
34Medulloblastoma (HP:0002885)3.76114761
35Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.58723497
36Neoplasm of the adrenal gland (HP:0100631)3.55425095
37Occipital encephalocele (HP:0002085)3.51999690
38Multiple lipomas (HP:0001012)3.50898523
39Myelomeningocele (HP:0002475)3.49858531
40Maternal diabetes (HP:0009800)3.44545066
41Abnormality of macrophages (HP:0004311)3.40241190
42Glioma (HP:0009733)3.38031636
43Adrenal hypoplasia (HP:0000835)3.38002548
44Keratoconjunctivitis (HP:0001096)3.27968011
45Tubulointerstitial fibrosis (HP:0005576)3.25239429
46Keratoconjunctivitis sicca (HP:0001097)3.24854008
47Viral hepatitis (HP:0006562)3.19667301
48Bowel incontinence (HP:0002607)3.15871946
49Abnormal hemoglobin (HP:0011902)3.11644119
50Abnormality of the umbilical cord (HP:0010881)3.07069082
51Neoplasm of the oral cavity (HP:0100649)3.06223662
52Barrel-shaped chest (HP:0001552)3.05770084
53Recurrent abscess formation (HP:0002722)3.01910706
54Recurrent bacterial skin infections (HP:0005406)3.01721941
55Loss of speech (HP:0002371)2.96926269
56Eczematoid dermatitis (HP:0000976)2.95569697
57Abnormal large intestine physiology (HP:0012700)2.94628398
58Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.93710018
59Prostate neoplasm (HP:0100787)2.90631818
60Supernumerary ribs (HP:0005815)2.89951562
61Leiomyosarcoma (HP:0100243)2.86561428
62Uterine leiomyosarcoma (HP:0002891)2.86561428
63Supernumerary bones of the axial skeleton (HP:0009144)2.86183940
64Limb hypertonia (HP:0002509)2.85282100
65T lymphocytopenia (HP:0005403)2.82427510
66Hepatocellular carcinoma (HP:0001402)2.80217316
67Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.75208422
68Combined immunodeficiency (HP:0005387)2.74507717
69Amaurosis fugax (HP:0100576)2.69707804
70Abnormality of lateral ventricle (HP:0030047)2.69622711
71Anorexia (HP:0002039)2.68837564
72Increased IgM level (HP:0003496)2.67785777
73Micronodular cirrhosis (HP:0001413)2.66901372
74Short tibia (HP:0005736)2.66823534
75Gastrointestinal infarctions (HP:0005244)2.64207118
76Premature ovarian failure (HP:0008209)2.62936791
77Tented upper lip vermilion (HP:0010804)2.59570460
78Anophthalmia (HP:0000528)2.59311119
79Hypochromic anemia (HP:0001931)2.58341818
80Apathy (HP:0000741)2.56471949
81Abnormality of T cell number (HP:0011839)2.54946942
82Abnormality of the frontal sinuses (HP:0002687)2.54554249
83Chromosomal breakage induced by crosslinking agents (HP:0003221)2.53288139
84Chromsome breakage (HP:0040012)2.52934879
85Cortical dysplasia (HP:0002539)2.51431658
86Keratitis (HP:0000491)2.51209236
87Diminished motivation (HP:0000745)2.50315715
88Recurrent fungal infections (HP:0002841)2.45088956
89IgG deficiency (HP:0004315)2.43921700
90Atelectasis (HP:0100750)2.43846082
91Transposition of the great arteries (HP:0001669)2.41887362
92Abnormal connection of the cardiac segments (HP:0011545)2.41887362
93Abnormal ventriculo-arterial connection (HP:0011563)2.41887362
94Urethral obstruction (HP:0000796)2.40451383
95Nephrogenic diabetes insipidus (HP:0009806)2.39059677
96Abnormality of the labia minora (HP:0012880)2.38722219
97Encephalitis (HP:0002383)2.38146112
98Severe combined immunodeficiency (HP:0004430)2.37547614
99Arterial thrombosis (HP:0004420)2.34751143
100Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.33428762
101Coarse hair (HP:0002208)2.29619859
102Leukocytosis (HP:0001974)2.28936579
103Absent rod-and cone-mediated responses on ERG (HP:0007688)2.28936028
104Hemoptysis (HP:0002105)2.28856672
105Aplasia/Hypoplasia of the tibia (HP:0005772)2.27921569
106Impulsivity (HP:0100710)2.27137764
107Abnormality of the prostate (HP:0008775)2.25790824
108Fibular hypoplasia (HP:0003038)2.25121175
109Transitional cell carcinoma of the bladder (HP:0006740)2.24596831
110Abnormality of eosinophils (HP:0001879)2.22023988
111Vasculitis (HP:0002633)2.18523918
112Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.16313232
113Parakeratosis (HP:0001036)2.15549646
114Polyneuropathy (HP:0001271)2.14295648
115Metaphyseal dysplasia (HP:0100255)2.14020507
116Abnormal hair whorl (HP:0010721)2.14006834
117Chest pain (HP:0100749)2.13660166
118Lymphedema (HP:0001004)2.11140167
119Hypokinesia (HP:0002375)2.09531939
120Focal segmental glomerulosclerosis (HP:0000097)2.08145493
121Shawl scrotum (HP:0000049)2.06482435
122Elevated erythrocyte sedimentation rate (HP:0003565)2.05850490
123Thickened nuchal skin fold (HP:0000474)2.05797741
124Abnormality of the heme biosynthetic pathway (HP:0010472)2.05666419
125Pulmonary infiltrates (HP:0002113)2.05317566
126Chronic bronchitis (HP:0004469)2.05009070
127Amyotrophic lateral sclerosis (HP:0007354)2.04711802
128Infantile muscular hypotonia (HP:0008947)2.03975332
129Thyroid carcinoma (HP:0002890)2.02995577
130Mediastinal lymphadenopathy (HP:0100721)2.01438798
131Tubulointerstitial abnormality (HP:0001969)2.00242383
132Recurrent gram-negative bacterial infections (HP:0005420)1.99742545
133Abnormality of T cells (HP:0002843)1.99691552
134Congenital primary aphakia (HP:0007707)1.99566121
135Oligodactyly (hands) (HP:0001180)1.99275407
136Anterior segment dysgenesis (HP:0007700)1.97961311
137Meningitis (HP:0001287)1.97768095
138Abnormality of glycolipid metabolism (HP:0010969)1.97472708
139Abnormality of liposaccharide metabolism (HP:0010968)1.97472708
140Abnormality of glycosphingolipid metabolism (HP:0004343)1.97472708
141Increased number of teeth (HP:0011069)1.97456736
142Radioulnar synostosis (HP:0002974)1.96627494
143Progressive inability to walk (HP:0002505)1.95837713
144Recurrent cutaneous fungal infections (HP:0011370)1.94163922
145Chronic mucocutaneous candidiasis (HP:0002728)1.94163922
146Vesicoureteral reflux (HP:0000076)1.94157640
147Bladder neoplasm (HP:0009725)1.93860880
148Bladder carcinoma (HP:0002862)1.93860880
149Gait imbalance (HP:0002141)1.91994307
150Pendular nystagmus (HP:0012043)1.91677478
151Inappropriate behavior (HP:0000719)1.91500573
152Myelodysplasia (HP:0002863)1.90445353
153Gonadotropin excess (HP:0000837)1.90189760
154Recurrent viral infections (HP:0004429)1.90092459
155Pulmonic stenosis (HP:0001642)1.89617560
156Hypoplasia of the brainstem (HP:0002365)1.88730421
157Aplasia/Hypoplasia of the brainstem (HP:0007362)1.88730421
158Secondary amenorrhea (HP:0000869)1.87943673
159Scrotal hypoplasia (HP:0000046)1.87039098
160Panhypogammaglobulinemia (HP:0003139)1.84260303
161Vacuolated lymphocytes (HP:0001922)1.83616521
162IgM deficiency (HP:0002850)1.83259652
163Abnormality of macular pigmentation (HP:0008002)1.83000940
164Abnormality of chromosome stability (HP:0003220)1.82504479
165Supernumerary spleens (HP:0009799)1.81833684
166Atrophy/Degeneration involving motor neurons (HP:0007373)1.81614872
167Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.81165474
168Eosinophilia (HP:0001880)1.80995846
169Septo-optic dysplasia (HP:0100842)1.80587590
170Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.79863634
171Abnormality of the septum pellucidum (HP:0007375)1.79304094
172Hepatitis (HP:0012115)1.78655937
173Protruding tongue (HP:0010808)1.78020384
174Urticaria (HP:0001025)1.77502518
175Gangrene (HP:0100758)1.77452420
176Melanocytic nevus (HP:0000995)1.76485104
177Recurrent skin infections (HP:0001581)1.76453768
178Slow saccadic eye movements (HP:0000514)1.75871985
179Absent hand (HP:0004050)1.74333841
180Absent septum pellucidum (HP:0001331)1.74224103
181Abnormal spermatogenesis (HP:0008669)1.73634485
182Embryonal neoplasm (HP:0002898)1.73627052
183Hypoplastic iliac wings (HP:0002866)1.73565357
184Abnormal respiratory motile cilium physiology (HP:0012261)1.73123087
185Conjugated hyperbilirubinemia (HP:0002908)1.73115473
186Medial flaring of the eyebrow (HP:0010747)1.72881397
187Rhinitis (HP:0012384)1.72076918
188Prenatal maternal abnormality (HP:0002686)1.70718354
189Abnormal gallbladder physiology (HP:0012438)1.69758822
190Cholecystitis (HP:0001082)1.69758822
191Osteomyelitis (HP:0002754)1.68898865
192Neonatal respiratory distress (HP:0002643)1.68871669
193Abnormality of the endocardium (HP:0004306)1.67100922
194Increased serum ferritin (HP:0003281)1.66576347
195Neoplasm of the tracheobronchial system (HP:0100552)1.66292101
196Attenuation of retinal blood vessels (HP:0007843)1.66018525
197Alveolar cell carcinoma (HP:0006519)1.65415826

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.36134114
2CSNK1A1L3.88008029
3CSNK1G33.54927492
4TRIM282.98444678
5NTRK32.87278872
6CSNK1G12.86914968
7CSNK1G22.86736722
8PINK12.81904637
9SIK32.81308032
10BCKDK2.79143128
11BUB12.66510699
12TXK2.60245512
13GRK62.58937929
14NUAK12.52919754
15TAOK32.37487739
16MAP3K132.36699405
17ARAF2.24658149
18TESK22.16417025
19EIF2AK32.07335396
20IKBKE2.02231363
21ICK12.1333425
22MAP3K141.97353166
23MAP4K11.92996213
24IRAK21.79436172
25WNK31.75766388
26TAOK11.63526437
27MAP3K41.57370441
28STK161.54573164
29BCR1.52312542
30IRAK11.49554813
31SRPK11.48044361
32MELK1.40042999
33BLK1.39598791
34PTK61.38420152
35ZAK1.38107086
36RAF11.37487596
37CDK71.33219477
38ZAP701.32910579
39MAP3K11.32488843
40PIM21.25058123
41TNK21.22936927
42TYK21.22128686
43STK101.21017852
44GRK71.18954248
45FGR1.15442597
46IRAK31.14716487
47CDC71.13472757
48BRAF1.07492427
49MARK31.02996579
50STK391.02532583
51MATK0.99650354
52TBK10.99326586
53SIK20.99218188
54WNK40.94925495
55CDK120.94590653
56IKBKB0.92592174
57MAP3K50.90403853
58CDK190.90169149
59PRPF4B0.87241284
60MAP3K90.87004303
61ERBB30.81891774
62LYN0.80054140
63NEK60.79669650
64VRK10.73952180
65LCK0.73919100
66MAP3K30.72208340
67SYK0.67186340
68MAPK70.65870087
69ADRBK20.64955496
70CHUK0.64219485
71KSR10.63545864
72CCNB10.63087095
73STK30.62598509
74CDK40.61950100
75CAMK1D0.61870055
76PRKCQ0.61597665
77MUSK0.61307736
78TAOK20.59006357
79TLK10.58518970
80CSNK1A10.58265523
81PIM10.58223314
82RPS6KA40.58183605
83DYRK1B0.57564758
84CHEK10.56919100
85MAP2K30.54449631
86MOS0.54410914
87CSK0.53159956
88CDK90.50454128
89EIF2AK20.50433193
90EPHA30.50384169
91KSR20.49235281
92EPHA20.49142596
93PLK40.48280525
94MST40.47371224
95MTOR0.46308068
96JAK20.45913811
97PRKCI0.45179349
98JAK10.43228825
99IRAK40.42632884
100MINK10.41212642
101ACVR1B0.41188934
102DYRK20.40823853
103PRKD20.40417118
104BTK0.39964093
105PTK2B0.39140570
106CAMK2B0.37702365
107ERBB40.37197906
108ALK0.36785718
109TGFBR20.36775368
110MAPK130.35840297
111MARK10.35545082
112MARK20.35235963
113PRKG10.34820489
114ITK0.34585403
115UHMK10.33492753
116CASK0.33198381
117EPHB10.32827333
118CAMK2D0.31563523
119PRKCH0.30007275
120EPHA40.28914605
121BRD40.28696793
122SIK10.25813674
123CAMK2A0.25444875
124RPS6KA30.24770666
125CSNK1D0.24683456
126TNIK0.24503957
127TTN0.24162482
128WNK10.23950851
129CDK50.23883079
130PLK20.23710794
131TEC0.23482557
132CSF1R0.22785823
133YES10.22559978
134DAPK20.22338230
135CAMK40.17811915
136FGFR40.17759219
137PNCK0.15583862
138AURKA0.15385708
139CSNK1E0.15338829
140STK380.14641180
141MAP2K20.13759259
142CAMKK10.13086873
143PRKCB0.13007576
144CDK20.12991452
145MAPK140.12724120
146PKN10.12648967
147LATS20.12390975
148CAMK2G0.12101339
149GSK3B0.11809076
150PRKACA0.11761601
151TTK0.11151061
152CLK10.10600977
153PRKACG0.09815893
154JAK30.09619530
155IGF1R0.09563017
156FYN0.08266028
157FER0.07694392
158AKT20.07043578
159RIPK40.06946901
160MAPK90.06487736
161NTRK20.06465010
162FES0.06217345
163MAPK30.06010746
164CDK30.05393513
165PLK10.04810674
166SGK30.04050426
167OXSR10.03999933
168HCK0.03681786

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043205.53267109
2Endometrial cancer_Homo sapiens_hsa052134.79263366
3Nicotine addiction_Homo sapiens_hsa050333.93398044
4Acute myeloid leukemia_Homo sapiens_hsa052213.13346802
5Basal transcription factors_Homo sapiens_hsa030222.98535213
6Basal cell carcinoma_Homo sapiens_hsa052172.83463252
7Primary immunodeficiency_Homo sapiens_hsa053402.50092999
8Glioma_Homo sapiens_hsa052142.46580701
9Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.36510017
10Cocaine addiction_Homo sapiens_hsa050302.26058769
11GnRH signaling pathway_Homo sapiens_hsa049122.16243256
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.15345953
13Non-small cell lung cancer_Homo sapiens_hsa052232.10396567
14Long-term potentiation_Homo sapiens_hsa047202.08758165
15ErbB signaling pathway_Homo sapiens_hsa040122.07266169
16Toll-like receptor signaling pathway_Homo sapiens_hsa046202.05650785
17Osteoclast differentiation_Homo sapiens_hsa043802.04465562
18Herpes simplex infection_Homo sapiens_hsa051682.01947156
19Prolactin signaling pathway_Homo sapiens_hsa049172.00259251
20Amphetamine addiction_Homo sapiens_hsa050311.97854766
21Legionellosis_Homo sapiens_hsa051341.96655124
22Alcoholism_Homo sapiens_hsa050341.94885995
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.93885255
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.93268734
25Measles_Homo sapiens_hsa051621.91595579
26Glutamatergic synapse_Homo sapiens_hsa047241.90279583
27Circadian entrainment_Homo sapiens_hsa047131.90067143
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.87379063
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.84477475
30Fanconi anemia pathway_Homo sapiens_hsa034601.82642075
31Mismatch repair_Homo sapiens_hsa034301.77295501
32Hepatitis B_Homo sapiens_hsa051611.77244032
33Renal cell carcinoma_Homo sapiens_hsa052111.76112205
34Gap junction_Homo sapiens_hsa045401.73685728
35Estrogen signaling pathway_Homo sapiens_hsa049151.72685654
36B cell receptor signaling pathway_Homo sapiens_hsa046621.71929597
37Cell cycle_Homo sapiens_hsa041101.69513301
38Base excision repair_Homo sapiens_hsa034101.68577714
39Chronic myeloid leukemia_Homo sapiens_hsa052201.61259268
40Leishmaniasis_Homo sapiens_hsa051401.58922386
41Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.56623732
42TNF signaling pathway_Homo sapiens_hsa046681.53265964
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.53021479
44RNA degradation_Homo sapiens_hsa030181.50007709
45RNA transport_Homo sapiens_hsa030131.49857281
46Malaria_Homo sapiens_hsa051441.47829049
47Influenza A_Homo sapiens_hsa051641.44613167
48T cell receptor signaling pathway_Homo sapiens_hsa046601.44463272
49Salivary secretion_Homo sapiens_hsa049701.44425053
50Shigellosis_Homo sapiens_hsa051311.41408809
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38059342
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36862856
53Regulation of autophagy_Homo sapiens_hsa041401.34912904
54Tuberculosis_Homo sapiens_hsa051521.33777435
55Calcium signaling pathway_Homo sapiens_hsa040201.32196942
56Phospholipase D signaling pathway_Homo sapiens_hsa040721.31827065
57Apoptosis_Homo sapiens_hsa042101.31717316
58Neurotrophin signaling pathway_Homo sapiens_hsa047221.30722565
59Taste transduction_Homo sapiens_hsa047421.29416234
60Homologous recombination_Homo sapiens_hsa034401.27627070
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.25660549
62Epstein-Barr virus infection_Homo sapiens_hsa051691.25307305
63Spliceosome_Homo sapiens_hsa030401.17579362
64Choline metabolism in cancer_Homo sapiens_hsa052311.15874661
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15422876
66Chemokine signaling pathway_Homo sapiens_hsa040621.15275568
67Viral carcinogenesis_Homo sapiens_hsa052031.14520494
68Proteasome_Homo sapiens_hsa030501.14377424
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07991292
70FoxO signaling pathway_Homo sapiens_hsa040681.06890155
71Colorectal cancer_Homo sapiens_hsa052101.06438252
72mRNA surveillance pathway_Homo sapiens_hsa030151.04805843
73MicroRNAs in cancer_Homo sapiens_hsa052061.04359194
74Nucleotide excision repair_Homo sapiens_hsa034201.03721318
75p53 signaling pathway_Homo sapiens_hsa041151.02899732
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.02368214
77Fatty acid elongation_Homo sapiens_hsa000621.00718895
78Prostate cancer_Homo sapiens_hsa052150.99490505
79Other glycan degradation_Homo sapiens_hsa005110.98068070
80Insulin secretion_Homo sapiens_hsa049110.97154974
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95491668
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94619893
83Cholinergic synapse_Homo sapiens_hsa047250.93621206
84Graft-versus-host disease_Homo sapiens_hsa053320.93469425
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.92176549
86Rheumatoid arthritis_Homo sapiens_hsa053230.91469150
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91238909
88Hematopoietic cell lineage_Homo sapiens_hsa046400.90015069
89RNA polymerase_Homo sapiens_hsa030200.89657967
90Inositol phosphate metabolism_Homo sapiens_hsa005620.89638972
91Hippo signaling pathway_Homo sapiens_hsa043900.88771460
92Insulin signaling pathway_Homo sapiens_hsa049100.88413338
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87367117
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.85243667
95Hedgehog signaling pathway_Homo sapiens_hsa043400.85180949
96Thyroid cancer_Homo sapiens_hsa052160.83443161
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83120346
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81227961
99Pathways in cancer_Homo sapiens_hsa052000.80526259
100Oocyte meiosis_Homo sapiens_hsa041140.80363649
101Wnt signaling pathway_Homo sapiens_hsa043100.77613399
102Synaptic vesicle cycle_Homo sapiens_hsa047210.76639350
103mTOR signaling pathway_Homo sapiens_hsa041500.76237772
104Non-homologous end-joining_Homo sapiens_hsa034500.75170583
105Selenocompound metabolism_Homo sapiens_hsa004500.74688780
106Salmonella infection_Homo sapiens_hsa051320.74314310
107Phagosome_Homo sapiens_hsa041450.73943365
108cAMP signaling pathway_Homo sapiens_hsa040240.73351047
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71381693
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71120233
111Circadian rhythm_Homo sapiens_hsa047100.70774257
112Toxoplasmosis_Homo sapiens_hsa051450.70673804
113Ovarian steroidogenesis_Homo sapiens_hsa049130.66122007
114Allograft rejection_Homo sapiens_hsa053300.65515571
115Ras signaling pathway_Homo sapiens_hsa040140.65469921
116Pancreatic cancer_Homo sapiens_hsa052120.64545906
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64474814
118GABAergic synapse_Homo sapiens_hsa047270.61990186
119Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61747597
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61735417
121Systemic lupus erythematosus_Homo sapiens_hsa053220.61287870
122Antigen processing and presentation_Homo sapiens_hsa046120.60649389
123MAPK signaling pathway_Homo sapiens_hsa040100.60644654
124Axon guidance_Homo sapiens_hsa043600.59915323
125Gastric acid secretion_Homo sapiens_hsa049710.59715912
126Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58877425
127HTLV-I infection_Homo sapiens_hsa051660.58307082
128HIF-1 signaling pathway_Homo sapiens_hsa040660.56849127
129Hepatitis C_Homo sapiens_hsa051600.55884388
130Protein export_Homo sapiens_hsa030600.55853778
131Endocytosis_Homo sapiens_hsa041440.53295130
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.52662938
133Morphine addiction_Homo sapiens_hsa050320.52516196
134Pertussis_Homo sapiens_hsa051330.52003462
135Lysosome_Homo sapiens_hsa041420.51581155
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.50154582
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44571313
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41934415
139Autoimmune thyroid disease_Homo sapiens_hsa053200.41638234
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.41561481
141Renin secretion_Homo sapiens_hsa049240.41487519
142Viral myocarditis_Homo sapiens_hsa054160.41426050
143Complement and coagulation cascades_Homo sapiens_hsa046100.40849261
144Arginine biosynthesis_Homo sapiens_hsa002200.40681347
145Bile secretion_Homo sapiens_hsa049760.39607511
146Proteoglycans in cancer_Homo sapiens_hsa052050.38900271
147Staphylococcus aureus infection_Homo sapiens_hsa051500.38342600
148Dilated cardiomyopathy_Homo sapiens_hsa054140.38114043
149Type II diabetes mellitus_Homo sapiens_hsa049300.37597200
150Focal adhesion_Homo sapiens_hsa045100.37020040
151Pancreatic secretion_Homo sapiens_hsa049720.36945039
152Alzheimers disease_Homo sapiens_hsa050100.35176428
153Serotonergic synapse_Homo sapiens_hsa047260.34449395
154Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34328653
155Nitrogen metabolism_Homo sapiens_hsa009100.32890064
156Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32119622
157Oxytocin signaling pathway_Homo sapiens_hsa049210.31446876
158Intestinal immune network for IgA production_Homo sapiens_hsa046720.30936754
159Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30634432
160Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29854008
161Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29432580
162Cardiac muscle contraction_Homo sapiens_hsa042600.27717633
163Phototransduction_Homo sapiens_hsa047440.27603701
164Histidine metabolism_Homo sapiens_hsa003400.26949144
165Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.25462898
166SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24335973
167Aldosterone synthesis and secretion_Homo sapiens_hsa049250.22368104
168DNA replication_Homo sapiens_hsa030300.22196042
169Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21681818
170Tryptophan metabolism_Homo sapiens_hsa003800.21625872
171Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.21370170
172Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.21027169
173Dopaminergic synapse_Homo sapiens_hsa047280.20578121
174Leukocyte transendothelial migration_Homo sapiens_hsa046700.19095402
175Rap1 signaling pathway_Homo sapiens_hsa040150.19003023
176PPAR signaling pathway_Homo sapiens_hsa033200.18136511

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