ZBTB46

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)6.99369192
2mesenchymal cell differentiation involved in kidney development (GO:0072161)6.37626655
3mesenchymal cell differentiation involved in renal system development (GO:2001012)6.37626655
4axonal fasciculation (GO:0007413)5.99461306
5NIK/NF-kappaB signaling (GO:0038061)5.99123176
6regulation of T-helper 1 cell differentiation (GO:0045625)5.89738657
7regulation of dendritic cell antigen processing and presentation (GO:0002604)5.79577351
8regulation of activation of Janus kinase activity (GO:0010533)4.94592892
9myeloid dendritic cell differentiation (GO:0043011)4.88820123
10regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.88517671
11regulation of RIG-I signaling pathway (GO:0039535)4.86635520
12positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.76985003
13positive regulation of interleukin-12 production (GO:0032735)4.70758523
14response to pheromone (GO:0019236)4.69597829
15mesenchymal to epithelial transition (GO:0060231)4.62071688
16neuron recognition (GO:0008038)4.60261434
17cell migration in hindbrain (GO:0021535)4.43581627
18positive regulation of T-helper cell differentiation (GO:0045624)4.32991533
19myeloid dendritic cell activation (GO:0001773)4.30530697
20skeletal muscle organ development (GO:0060538)4.23287522
21diaphragm development (GO:0060539)4.19395110
22positive regulation of antigen processing and presentation (GO:0002579)4.16481984
23regulation of interleukin-12 biosynthetic process (GO:0045075)4.13172300
24positive regulation of natural killer cell differentiation (GO:0032825)4.01229819
25positive regulation of type 2 immune response (GO:0002830)3.96894202
26lymph vessel development (GO:0001945)3.96480322
27substrate-independent telencephalic tangential migration (GO:0021826)3.94073888
28substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.94073888
29response to prostaglandin E (GO:0034695)3.92790604
30regulation of synapse structural plasticity (GO:0051823)3.87667341
31dendritic cell differentiation (GO:0097028)3.84145669
32positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.82919948
33negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.75326134
34G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.67435715
35camera-type eye morphogenesis (GO:0048593)3.64168004
36vascular endothelial growth factor signaling pathway (GO:0038084)3.60572736
37dendritic spine morphogenesis (GO:0060997)3.60462008
38layer formation in cerebral cortex (GO:0021819)3.58648298
39growth hormone receptor signaling pathway (GO:0060396)3.56209774
40regulation of T-helper 2 cell differentiation (GO:0045628)3.52059335
41protein localization to synapse (GO:0035418)3.49040366
42behavioral response to nicotine (GO:0035095)3.47845792
43cell-cell junction maintenance (GO:0045217)3.46902776
44regulation of antigen processing and presentation (GO:0002577)3.46589802
45regulation of T-helper cell differentiation (GO:0045622)3.46408359
46regulation of memory T cell differentiation (GO:0043380)3.44109002
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.42891142
48positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.41172863
49monocyte chemotaxis (GO:0002548)3.39062654
50regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.36620805
51response to muramyl dipeptide (GO:0032495)3.35107574
52T-helper 1 type immune response (GO:0042088)3.33799279
53CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.33508564
54T-helper cell differentiation (GO:0042093)3.33508564
55adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.33481016
56regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.30568900
57regulation of synapse maturation (GO:0090128)3.29111196
58positive regulation of synapse maturation (GO:0090129)3.27836784
59neuronal ion channel clustering (GO:0045161)3.27412657
60striated muscle atrophy (GO:0014891)3.26298637
61myelination in peripheral nervous system (GO:0022011)3.23736013
62peripheral nervous system axon ensheathment (GO:0032292)3.23736013
63pyrimidine nucleobase catabolic process (GO:0006208)3.22680260
64dendritic cell chemotaxis (GO:0002407)3.22009947
65regulation of interleukin-12 production (GO:0032655)3.21087390
66heterochromatin organization (GO:0070828)3.20429921
67positive regulation of T-helper 1 type immune response (GO:0002827)3.20288811
68antigen processing and presentation of endogenous antigen (GO:0019883)3.19365608
69ganglion development (GO:0061548)3.18650202
70positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.13943418
71cellular response to zinc ion (GO:0071294)3.09265583
72sensory perception of taste (GO:0050909)3.08403814
73regulation of T-helper 1 type immune response (GO:0002825)3.08097428
74cellular response to growth hormone stimulus (GO:0071378)3.07236848
75neuron cell-cell adhesion (GO:0007158)3.07144573
76positive regulation of macrophage cytokine production (GO:0060907)3.06205990
77positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.05642432
78genetic imprinting (GO:0071514)3.04157534
79muscle atrophy (GO:0014889)3.03007118
80synaptic transmission, cholinergic (GO:0007271)3.02199182
81regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.01989096
82axon extension (GO:0048675)3.01912457
83mannose metabolic process (GO:0006013)2.97905065
84neurotransmitter-gated ion channel clustering (GO:0072578)2.94526642
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.93048043
86surfactant homeostasis (GO:0043129)2.91321331
87regulation of T cell tolerance induction (GO:0002664)2.88520883
88T cell differentiation involved in immune response (GO:0002292)2.85894390
89alpha-beta T cell differentiation involved in immune response (GO:0002293)2.85894390
90alpha-beta T cell activation involved in immune response (GO:0002287)2.85894390
91regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.84494532
92regulation of alpha-beta T cell proliferation (GO:0046640)2.83979065
93positive regulation of protein kinase C signaling (GO:0090037)2.83617436
94dendritic cell migration (GO:0036336)2.83560255
95dendrite development (GO:0016358)2.83553992
96ionotropic glutamate receptor signaling pathway (GO:0035235)2.83437794
97positive regulation of alpha-beta T cell proliferation (GO:0046641)2.82534281
98skeletal muscle adaptation (GO:0043501)2.79880843
99regulation of mesonephros development (GO:0061217)2.79819690
100semaphorin-plexin signaling pathway (GO:0071526)2.79776118
101cell differentiation involved in kidney development (GO:0061005)2.79604203
102cell junction maintenance (GO:0034331)2.78766484
103spinal cord association neuron differentiation (GO:0021527)2.77353063
104gamma-aminobutyric acid transport (GO:0015812)2.76230375
105chromatin silencing (GO:0006342)2.75991842
106respiratory system process (GO:0003016)2.75433579
107regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.74369420
108regulation of glycogen (starch) synthase activity (GO:2000465)2.73274168
109regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.72120476
110interferon-gamma-mediated signaling pathway (GO:0060333)2.71149651
111dopamine receptor signaling pathway (GO:0007212)2.70928627
112mitochondrion transport along microtubule (GO:0047497)2.70785481
113establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.70785481
114endothelium development (GO:0003158)2.70140677
115response to prostaglandin (GO:0034694)2.69831896
116ribosomal small subunit biogenesis (GO:0042274)2.69650446
117cellular response to exogenous dsRNA (GO:0071360)2.68227137
118neutrophil activation (GO:0042119)2.68039796
119natural killer cell mediated cytotoxicity (GO:0042267)2.67379441
120natural killer cell mediated immunity (GO:0002228)2.67379441
121regulation of hypersensitivity (GO:0002883)2.67083392
122cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.64547618
123protein polyglutamylation (GO:0018095)2.64351618
124positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.63711455
125positive regulation of neutrophil migration (GO:1902624)2.63709846
126positive regulation of neutrophil chemotaxis (GO:0090023)2.63709846
127cell proliferation in forebrain (GO:0021846)2.63271636
128regulation of interleukin-1 beta secretion (GO:0050706)2.63079779
129regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.62956069
130positive regulation of activated T cell proliferation (GO:0042104)2.60531571
131positive regulation of interleukin-2 production (GO:0032743)2.59586813
132regulation of glutamate receptor signaling pathway (GO:1900449)2.59522953
133epithelial cell differentiation involved in kidney development (GO:0035850)2.59343380
134ovulation from ovarian follicle (GO:0001542)2.59307608
135postsynaptic membrane organization (GO:0001941)2.58906843
136heart valve formation (GO:0003188)2.57945606
137positive regulation of vasculogenesis (GO:2001214)2.57527468
138regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.57200175
139regulation of skeletal muscle contraction (GO:0014819)2.56263642
140regulation of cilium assembly (GO:1902017)2.55727057
141body morphogenesis (GO:0010171)2.54824869
142auditory behavior (GO:0031223)2.54570171
143regulation of immunoglobulin secretion (GO:0051023)2.54474197
144spinal cord development (GO:0021510)2.52919199
145cerebellar Purkinje cell differentiation (GO:0021702)2.52632501
146positive regulation of neurological system process (GO:0031646)2.52188026
147neuromuscular synaptic transmission (GO:0007274)2.52187847
148endoderm formation (GO:0001706)2.51741378
149cellular response to type I interferon (GO:0071357)2.51729918
150type I interferon signaling pathway (GO:0060337)2.51729918
151positive regulation of heat generation (GO:0031652)2.50503666
152ventricular trabecula myocardium morphogenesis (GO:0003222)2.50085813
153negative thymic T cell selection (GO:0045060)2.49970778
154left/right pattern formation (GO:0060972)2.49366181
155positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.49345209
156establishment of mitochondrion localization (GO:0051654)2.49292751
157vocalization behavior (GO:0071625)2.49288994
158chemical homeostasis within a tissue (GO:0048875)2.48215640
159positive regulation of T cell cytokine production (GO:0002726)2.48193700
160receptor catabolic process (GO:0032801)2.48068277
161positive regulation of granulocyte chemotaxis (GO:0071624)2.47419761
162leukocyte tethering or rolling (GO:0050901)2.47332803
163negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.46563312
164negative regulation of catenin import into nucleus (GO:0035414)2.46456917
165activation of MAPKKK activity (GO:0000185)2.45642362
166synapse assembly (GO:0007416)2.45165488
167dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.44946300
168central nervous system myelination (GO:0022010)2.44898848
169axon ensheathment in central nervous system (GO:0032291)2.44898848
170middle ear morphogenesis (GO:0042474)2.44845299
171synaptic transmission, glutamatergic (GO:0035249)2.44758241
172response to type I interferon (GO:0034340)2.44508773
173negative regulation of mast cell activation (GO:0033004)2.44484637
174positive regulation of humoral immune response (GO:0002922)2.44168328
175embryonic digestive tract morphogenesis (GO:0048557)2.43441170
176telencephalon development (GO:0021537)2.43306615
177negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.43136115
178retina vasculature morphogenesis in camera-type eye (GO:0061299)2.42719648
179regulation of microtubule-based movement (GO:0060632)2.42278392
180positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.41645156
181adenosine receptor signaling pathway (GO:0001973)2.41622519
182granulocyte activation (GO:0036230)2.40826965
183CD4-positive, alpha-beta T cell activation (GO:0035710)2.40684894
184microtubule severing (GO:0051013)2.40578248
185negative regulation of axon extension (GO:0030517)2.39788517
186membrane depolarization during action potential (GO:0086010)2.38351437
187necroptotic process (GO:0070266)2.38142869
188response to nitric oxide (GO:0071731)2.38058675
189regulation of synaptic vesicle transport (GO:1902803)2.37743176
190positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.36992558
191histamine secretion (GO:0001821)2.36598861
192positive regulation of triglyceride biosynthetic process (GO:0010867)2.36409874
193regulation of cellular extravasation (GO:0002691)2.36013394
194neuron projection extension (GO:1990138)2.35095345
195cerebellar granule cell differentiation (GO:0021707)2.29699138
196mesenchymal cell differentiation (GO:0048762)2.29698774
197arginine catabolic process (GO:0006527)2.29473954
198regulation of axon extension involved in axon guidance (GO:0048841)2.29174775

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD_19615063_ChIP-ChIP_OVARY_Human3.94347906
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.91524768
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.55762763
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.39967840
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.36872960
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.35467536
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.15325444
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.13462733
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.97037622
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.84320103
11ERG_21242973_ChIP-ChIP_JURKAT_Human2.81648691
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.74971023
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.58409657
14* KDM2B_26808549_Chip-Seq_K562_Human2.50248073
15IGF1R_20145208_ChIP-Seq_DFB_Human2.43359354
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.40210361
17LXR_22292898_ChIP-Seq_THP-1_Human2.34128804
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.32681677
19KDM2B_26808549_Chip-Seq_SUP-B15_Human2.31962544
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28128508
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.24298947
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.19105711
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11731070
24IRF8_27001747_Chip-Seq_BMDM_Mouse2.07843169
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.01480906
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.99057211
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94898694
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.94037543
29EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.93423030
30CTCF_27219007_Chip-Seq_Bcells_Human1.91416494
31GBX2_23144817_ChIP-Seq_PC3_Human1.89851007
32REST_21632747_ChIP-Seq_MESCs_Mouse1.87966210
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.86511566
34EZH2_22144423_ChIP-Seq_EOC_Human1.85490393
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.84629246
36RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.84102708
37KDM2B_26808549_Chip-Seq_DND41_Human1.82031214
38CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.78530509
39VDR_21846776_ChIP-Seq_THP-1_Human1.76504117
40REST_18959480_ChIP-ChIP_MESCs_Mouse1.74043886
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.74015522
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.71193639
43* RING1B_27294783_Chip-Seq_ESCs_Mouse1.70867721
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.70638779
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69876946
46P68_20966046_ChIP-Seq_HELA_Human1.69676735
47SMC4_20622854_ChIP-Seq_HELA_Human1.67373516
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67086566
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.66501682
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66501682
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.63251941
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60973782
53VDR_24787735_ChIP-Seq_THP-1_Human1.59977736
54TP53_20018659_ChIP-ChIP_R1E_Mouse1.58560732
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57675581
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.56403024
57OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.54767472
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53696107
59SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51834808
60ZFP281_27345836_Chip-Seq_ESCs_Mouse1.51808125
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51737143
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.51378606
63* RING1B_27294783_Chip-Seq_NPCs_Mouse1.51334041
64MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.50442919
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.50427531
66KDM2B_26808549_Chip-Seq_JURKAT_Human1.50044736
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49083390
68JARID2_20064375_ChIP-Seq_MESCs_Mouse1.46203334
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44705883
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44687929
71EP300_21415370_ChIP-Seq_HL-1_Mouse1.43505704
72P300_19829295_ChIP-Seq_ESCs_Human1.42677868
73TAF15_26573619_Chip-Seq_HEK293_Human1.42053761
74RUNX_20019798_ChIP-Seq_JUKART_Human1.40213264
75* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39914976
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38176691
77RARB_27405468_Chip-Seq_BRAIN_Mouse1.36941588
78OCT4_19829295_ChIP-Seq_ESCs_Human1.36668673
79SMAD4_21799915_ChIP-Seq_A2780_Human1.36285548
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.35889437
81* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34006431
82PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32428885
83SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32224007
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30855809
85RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30259258
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30035970
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29992892
88SA1_27219007_Chip-Seq_ERYTHROID_Human1.28224061
89CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.27538148
90IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26937067
91SALL1_21062744_ChIP-ChIP_HESCs_Human1.26008012
92SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24193310
93CREB1_26743006_Chip-Seq_LNCaP_Human1.24056608
94SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23845638
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23504143
96ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21603771
97STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.21211097
98TCF7_22412390_ChIP-Seq_EML_Mouse1.20800280
99SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20792599
100BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19234070
101TCF4_18268006_ChIP-ChIP_LS174T_Human1.19214678
102RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17664636
103SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17608875
104ESR2_21235772_ChIP-Seq_MCF-7_Human1.17332016
105RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17057025
106* E2F1_18555785_Chip-Seq_ESCs_Mouse1.16971235
107NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15529789
108RACK7_27058665_Chip-Seq_MCF-7_Human1.14384870
109P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13795666
110STAT3_18555785_Chip-Seq_ESCs_Mouse1.12606650
111EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12461104
112RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12461104
113GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11869598
114* RNF2_27304074_Chip-Seq_ESCs_Mouse1.11117824
115SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10730440
116ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10474676
117UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10165413
118SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09819795
119KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09650201
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09550348
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08759746
122NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08736388
123EZH2_27294783_Chip-Seq_NPCs_Mouse1.08704840
124EED_16625203_ChIP-ChIP_MESCs_Mouse1.08530177
125EZH2_27304074_Chip-Seq_ESCs_Mouse1.07537207
126SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07303474
127EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06732800
128SOX3_22085726_ChIP-Seq_NPCs_Mouse1.06716922
129SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06399502
130SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.06368787
131* NMYC_18555785_Chip-Seq_ESCs_Mouse1.05885912
132ER_23166858_ChIP-Seq_MCF-7_Human1.05359450
133TP53_22127205_ChIP-Seq_IMR90_Human1.04998739
134AR_25329375_ChIP-Seq_VCAP_Human1.04196926
135CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04164803
136FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.04060392
137MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03852956
138MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03742782
139FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02746463
140SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02606475
141P53_22387025_ChIP-Seq_ESCs_Mouse1.02158296
142* CMYC_18555785_Chip-Seq_ESCs_Mouse1.01572335
143EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01086861
144RUNX1_26923725_Chip-Seq_HPCs_Mouse1.00947904
145CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00787250
146ISL1_27105846_Chip-Seq_CPCs_Mouse1.00770482
147PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00554782
148ELK3_25401928_ChIP-Seq_HUVEC_Human0.99865087
149STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98708453
150AHR_22903824_ChIP-Seq_MCF-7_Human0.98152204
151NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97717674
152RNF2_27304074_Chip-Seq_NSC_Mouse0.97704327
153STAT3_23295773_ChIP-Seq_U87_Human0.97031506
154TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.96926738
155SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96488189
156PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96450723
157NFE2_27457419_Chip-Seq_LIVER_Mouse0.95894358
158KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.95188252
159NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95142100
160KLF4_19829295_ChIP-Seq_ESCs_Human0.94711357
161CBX2_27304074_Chip-Seq_ESCs_Mouse0.94670327
162PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94507817
163* OCT4_18555785_Chip-Seq_ESCs_Mouse0.94298655
164SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93572512
165DROSHA_22980978_ChIP-Seq_HELA_Human0.93566633
166NOTCH1_21737748_ChIP-Seq_TLL_Human0.93033359
167KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92934504
168CJUN_26792858_Chip-Seq_BT549_Human0.92788082
169MYC_27129775_Chip-Seq_CORNEA_Mouse0.92617021
170FOXP1_21924763_ChIP-Seq_HESCs_Human0.92583815
171* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91930274
172* DPY_21335234_ChIP-Seq_ESCs_Mouse0.91795780
173* PU1_27457419_Chip-Seq_LIVER_Mouse0.91198454
174PRDM14_20953172_ChIP-Seq_ESCs_Human0.91160027
175SA1_27219007_Chip-Seq_Bcells_Human0.91142279
176RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91036750
177PHF8_20622854_ChIP-Seq_HELA_Human0.90857538
178CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88780433
179SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87793851
180* TP53_23651856_ChIP-Seq_MEFs_Mouse0.87502165

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system4.63700775
2MP0001835_abnormal_antigen_presentation4.52279609
3MP0004510_myositis4.42963104
4MP0005423_abnormal_somatic_nervous4.00287753
5MP0005409_darkened_coat_color3.36627929
6MP0010368_abnormal_lymphatic_system3.16874386
7MP0001879_abnormal_lymphatic_vessel3.08003437
8MP0000685_abnormal_immune_system3.00603093
9MP0002163_abnormal_gland_morphology2.90877416
10MP0003123_paternal_imprinting2.77308777
11MP0005671_abnormal_response_to2.77298554
12MP0002148_abnormal_hypersensitivity_rea2.70513089
13MP0004859_abnormal_synaptic_plasticity2.67818996
14MP0000569_abnormal_digit_pigmentation2.63589283
15MP0003724_increased_susceptibility_to2.50352961
16MP0009785_altered_susceptibility_to2.27070259
17MP0001348_abnormal_lacrimal_gland2.26351373
18MP0005499_abnormal_olfactory_system2.13948501
19MP0005394_taste/olfaction_phenotype2.13948501
20MP0004270_analgesia2.12987746
21MP0005310_abnormal_salivary_gland2.10641253
22MP0000566_synostosis2.07433855
23MP0001986_abnormal_taste_sensitivity2.02979369
24MP0005257_abnormal_intraocular_pressure2.01646388
25MP0005387_immune_system_phenotype1.99330004
26MP0001790_abnormal_immune_system1.99330004
27MP0008995_early_reproductive_senescence1.98279390
28MP0004742_abnormal_vestibular_system1.96440464
29MP0004147_increased_porphyrin_level1.93901049
30MP0002876_abnormal_thyroid_physiology1.91439879
31MP0004130_abnormal_muscle_cell1.90216279
32MP0003942_abnormal_urinary_system1.86398484
33MP0001440_abnormal_grooming_behavior1.85738815
34MP0008789_abnormal_olfactory_epithelium1.84022184
35MP0003635_abnormal_synaptic_transmissio1.81408084
36MP0009764_decreased_sensitivity_to1.80548671
37MP0004133_heterotaxia1.78592239
38MP0009379_abnormal_foot_pigmentation1.76892313
39MP0002063_abnormal_learning/memory/cond1.72905186
40MP0005167_abnormal_blood-brain_barrier1.70023807
41MP0003879_abnormal_hair_cell1.69905354
42MP0002254_reproductive_system_inflammat1.69539779
43MP0000767_abnormal_smooth_muscle1.69441662
44MP0004858_abnormal_nervous_system1.67838227
45MP0004782_abnormal_surfactant_physiolog1.67561762
46MP0005000_abnormal_immune_tolerance1.66741691
47MP0001346_abnormal_lacrimal_gland1.63541547
48MP0001800_abnormal_humoral_immune1.62805254
49MP0003787_abnormal_imprinting1.60598815
50MP0003646_muscle_fatigue1.60068965
51MP0008057_abnormal_DNA_replication1.59830389
52MP0003828_pulmonary_edema1.59626676
53MP0002452_abnormal_antigen_presenting1.59046509
54MP0002277_abnormal_respiratory_mucosa1.56737559
55MP0003283_abnormal_digestive_organ1.56632421
56MP0004084_abnormal_cardiac_muscle1.56008436
57MP0000955_abnormal_spinal_cord1.52043193
58MP0009745_abnormal_behavioral_response1.50524338
59MP0002064_seizures1.49570974
60MP0004272_abnormal_basement_membrane1.48363374
61MP0002127_abnormal_cardiovascular_syste1.48187374
62MP0002102_abnormal_ear_morphology1.47052497
63MP0006138_congestive_heart_failure1.46699236
64MP0005025_abnormal_response_to1.44612228
65MP0002723_abnormal_immune_serum1.43755298
66MP0002272_abnormal_nervous_system1.43659550
67MP0002419_abnormal_innate_immunity1.42576836
68MP0004215_abnormal_myocardial_fiber1.42073468
69MP0001970_abnormal_pain_threshold1.40772002
70MP0001819_abnormal_immune_cell1.40647559
71MP0001968_abnormal_touch/_nociception1.40126306
72MP0004233_abnormal_muscle_weight1.35794999
73MP0008775_abnormal_heart_ventricle1.32518252
74MP0002420_abnormal_adaptive_immunity1.32503735
75MP0002734_abnormal_mechanical_nocicepti1.30630153
76MP0001853_heart_inflammation1.30038853
77MP0003943_abnormal_hepatobiliary_system1.28259930
78MP0002160_abnormal_reproductive_system1.25465413
79MP0001486_abnormal_startle_reflex1.22053928
80MP0001915_intracranial_hemorrhage1.20639948
81MP0002572_abnormal_emotion/affect_behav1.20110978
82MP0002557_abnormal_social/conspecific_i1.19608141
83MP0005379_endocrine/exocrine_gland_phen1.19051837
84MP0003878_abnormal_ear_physiology1.18230653
85MP0005377_hearing/vestibular/ear_phenot1.18230653
86MP0009697_abnormal_copulation1.17134825
87MP0002882_abnormal_neuron_morphology1.16486311
88MP0003436_decreased_susceptibility_to1.16303371
89MP0002733_abnormal_thermal_nociception1.15916910
90MP0002166_altered_tumor_susceptibility1.11544203
91MP0004885_abnormal_endolymph1.10898066
92MP0002009_preneoplasia1.10455420
93MP0002089_abnormal_postnatal_growth/wei1.09638577
94MP0002152_abnormal_brain_morphology1.09173374
95MP0002405_respiratory_system_inflammati1.06835296
96MP0002006_tumorigenesis1.06611169
97MP0003121_genomic_imprinting1.06244055
98MP0003880_abnormal_central_pattern1.06225824
99MP0002735_abnormal_chemical_nociception1.05888289
100MP0003091_abnormal_cell_migration1.05421443
101MP0002752_abnormal_somatic_nervous1.04731390
102MP0002398_abnormal_bone_marrow1.04108796
103MP0002396_abnormal_hematopoietic_system1.03858400
104MP0001873_stomach_inflammation1.03647612
105MP0000026_abnormal_inner_ear1.03352547
106MP0003136_yellow_coat_color1.02283329
107MP0001529_abnormal_vocalization1.01098218
108MP0009053_abnormal_anal_canal1.00156198
109MP0003938_abnormal_ear_development0.99120864
110MP0002972_abnormal_cardiac_muscle0.98495143
111MP0004811_abnormal_neuron_physiology0.98485463
112MP0002116_abnormal_craniofacial_bone0.97843888
113MP0000750_abnormal_muscle_regeneration0.97135414
114MP0006276_abnormal_autonomic_nervous0.96957229
115MP0003861_abnormal_nervous_system0.96754446
116MP0001119_abnormal_female_reproductive0.96359115
117MP0005645_abnormal_hypothalamus_physiol0.96027344
118MP0000716_abnormal_immune_system0.94654019
119MP0000049_abnormal_middle_ear0.93784493
120MP0005385_cardiovascular_system_phenoty0.92790214
121MP0001544_abnormal_cardiovascular_syste0.92790214
122MP0002332_abnormal_exercise_endurance0.92663560
123MP0000343_altered_response_to0.92013490
124MP0002249_abnormal_larynx_morphology0.91820206
125MP0005174_abnormal_tail_pigmentation0.91717911
126MP0004145_abnormal_muscle_electrophysio0.91624087
127MP0003448_altered_tumor_morphology0.91216641
128MP0002184_abnormal_innervation0.90359155
129MP0005647_abnormal_sex_gland0.90123408
130MP0001188_hyperpigmentation0.89900297
131MP0002067_abnormal_sensory_capabilities0.89248461
132MP0000537_abnormal_urethra_morphology0.89202823
133MP0001502_abnormal_circadian_rhythm0.89017480
134MP0008877_abnormal_DNA_methylation0.89014619
135MP0003119_abnormal_digestive_system0.88761855
136MP0002697_abnormal_eye_size0.88490023
137MP0000631_abnormal_neuroendocrine_gland0.88397468
138MP0001919_abnormal_reproductive_system0.87883770
139MP0000751_myopathy0.87048540
140MP0002837_dystrophic_cardiac_calcinosis0.87042622
141MP0000778_abnormal_nervous_system0.86490648
142MP0003329_amyloid_beta_deposits0.85184434
143MP0003122_maternal_imprinting0.85079894
144MP0002234_abnormal_pharynx_morphology0.84343229
145MP0002653_abnormal_ependyma_morphology0.83567540
146MP0001293_anophthalmia0.83003353
147MP0003385_abnormal_body_wall0.82331018
148MP0001485_abnormal_pinna_reflex0.82246442
149MP0001545_abnormal_hematopoietic_system0.82098048
150MP0005397_hematopoietic_system_phenotyp0.82098048
151MP0004484_altered_response_of0.81190321
152MP0005084_abnormal_gallbladder_morpholo0.80293565
153MP0006082_CNS_inflammation0.79379276
154MP0003315_abnormal_perineum_morphology0.78828443
155MP0002429_abnormal_blood_cell0.77419414
156MP0004142_abnormal_muscle_tone0.77352696
157MP0001963_abnormal_hearing_physiology0.77024691
158MP0002066_abnormal_motor_capabilities/c0.75934653
159MP0009046_muscle_twitch0.75155308
160MP0000249_abnormal_blood_vessel0.75108086
161MP0010630_abnormal_cardiac_muscle0.75095759
162MP0003763_abnormal_thymus_physiology0.75090446
163MP0005195_abnormal_posterior_eye0.74959348
164MP0005670_abnormal_white_adipose0.74766130
165MP0002081_perinatal_lethality0.74092315
166MP0004036_abnormal_muscle_relaxation0.73426186
167MP0000534_abnormal_ureter_morphology0.72101414
168MP0010030_abnormal_orbit_morphology0.70278210
169MP0005187_abnormal_penis_morphology0.69999197
170MP0003937_abnormal_limbs/digits/tail_de0.69404510
171MP0002822_catalepsy0.68082231
172MP0001845_abnormal_inflammatory_respons0.65881112
173MP0006292_abnormal_olfactory_placode0.63904917
174MP0010386_abnormal_urinary_bladder0.62703614
175MP0002638_abnormal_pupillary_reflex0.62523505
176MP0004085_abnormal_heartbeat0.62255961
177MP0005623_abnormal_meninges_morphology0.61974781
178MP0005451_abnormal_body_composition0.61234871
179MP0002928_abnormal_bile_duct0.60911151
180MP0000015_abnormal_ear_pigmentation0.60672670

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)4.23817800
2Retrobulbar optic neuritis (HP:0100654)4.11734158
3Optic neuritis (HP:0100653)4.11734158
4Abnormality of the aortic arch (HP:0012303)3.96094787
5Annular pancreas (HP:0001734)3.92851784
6Papillary thyroid carcinoma (HP:0002895)3.86340149
7Increased IgM level (HP:0003496)3.82415119
8Intestinal fistula (HP:0100819)3.76703442
9Turricephaly (HP:0000262)3.73385657
10Recurrent abscess formation (HP:0002722)3.62463129
11Myokymia (HP:0002411)3.60091156
12Cortical dysplasia (HP:0002539)3.52508971
13Recurrent bacterial skin infections (HP:0005406)3.50064323
14Orchitis (HP:0100796)3.43231493
15Mediastinal lymphadenopathy (HP:0100721)3.26498023
16Porencephaly (HP:0002132)3.25186230
17Polycythemia (HP:0001901)3.22602224
18Thin bony cortex (HP:0002753)3.21195230
19Hematochezia (HP:0002573)3.16358453
20Gastrointestinal infarctions (HP:0005244)3.06276258
21Long palpebral fissure (HP:0000637)3.04903936
22Aplasia of the musculature (HP:0100854)2.95110053
23Pulmonary infiltrates (HP:0002113)2.95045138
24Abnormality of the fingertips (HP:0001211)2.94249187
25Nephronophthisis (HP:0000090)2.90324220
26Prostate neoplasm (HP:0100787)2.89681737
27Tetraparesis (HP:0002273)2.84984676
28Abnormality of the hepatic vasculature (HP:0006707)2.84811371
29Abnormal hair whorl (HP:0010721)2.82666312
30Portal hypertension (HP:0001409)2.80649169
31Keratoconjunctivitis (HP:0001096)2.78629259
32Myositis (HP:0100614)2.77574600
33Abnormality of the pulmonary veins (HP:0011718)2.72894938
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.72283171
35Chromsome breakage (HP:0040012)2.70555365
36Arterial thrombosis (HP:0004420)2.69414712
37Thyroid carcinoma (HP:0002890)2.68895970
38Abnormality of cochlea (HP:0000375)2.64875944
39Eczematoid dermatitis (HP:0000976)2.63570123
40Vasculitis (HP:0002633)2.62397382
41Chronic mucocutaneous candidiasis (HP:0002728)2.61339950
42Recurrent cutaneous fungal infections (HP:0011370)2.61339950
43Acute myeloid leukemia (HP:0004808)2.59695663
44Recurrent fungal infections (HP:0002841)2.58825166
45Polyphagia (HP:0002591)2.57265009
46Anomalous pulmonary venous return (HP:0010772)2.56749381
47Obstructive sleep apnea (HP:0002870)2.56566532
48Abnormality of midbrain morphology (HP:0002418)2.56424082
49Molar tooth sign on MRI (HP:0002419)2.56424082
50Capillary hemangiomas (HP:0005306)2.54209599
51Keratoconjunctivitis sicca (HP:0001097)2.53333056
52Reticulocytopenia (HP:0001896)2.50037700
53Midline defect of the nose (HP:0004122)2.49917109
54Fetal akinesia sequence (HP:0001989)2.49639809
55Exotropia (HP:0000577)2.48354229
56Hemoptysis (HP:0002105)2.46834740
57Shawl scrotum (HP:0000049)2.46774430
58Hepatoblastoma (HP:0002884)2.46389883
59Esophageal varix (HP:0002040)2.40303601
60Genetic anticipation (HP:0003743)2.38901661
61Hyperthyroidism (HP:0000836)2.36521828
62Pulmonary artery stenosis (HP:0004415)2.36036825
63Spontaneous hematomas (HP:0007420)2.35286801
64Drooling (HP:0002307)2.35041618
65Neonatal hypoglycemia (HP:0001998)2.33494552
66Urinary bladder sphincter dysfunction (HP:0002839)2.32349579
67Alveolar cell carcinoma (HP:0006519)2.30249647
68Mask-like facies (HP:0000298)2.29190488
69Focal seizures (HP:0007359)2.28814474
70Absent hand (HP:0004050)2.28497765
71Atonic seizures (HP:0010819)2.28075474
72Abnormal delayed hypersensitivity skin test (HP:0002963)2.27209333
73Periodontitis (HP:0000704)2.25252089
74Periauricular skin pits (HP:0100277)2.24992681
75Preauricular pit (HP:0004467)2.24992681
76Akinesia (HP:0002304)2.23724817
77Agammaglobulinemia (HP:0004432)2.22234069
78Atrial fibrillation (HP:0005110)2.22131661
79Abnormal eating behavior (HP:0100738)2.21396058
80Abnormality of the renal medulla (HP:0100957)2.20323659
81Osteomalacia (HP:0002749)2.19901464
82Recurrent skin infections (HP:0001581)2.19548088
83Recurrent viral infections (HP:0004429)2.19158566
84Enlarged penis (HP:0000040)2.17420983
85Aplasia involving bones of the extremities (HP:0009825)2.16837468
86Aplasia involving bones of the upper limbs (HP:0009823)2.16837468
87Aplasia of the phalanges of the hand (HP:0009802)2.16837468
88Skull defect (HP:0001362)2.16391347
89Primary atrial arrhythmia (HP:0001692)2.13836635
90Stomach cancer (HP:0012126)2.13755174
91Neoplasm of the tracheobronchial system (HP:0100552)2.13413597
92Adactyly (HP:0009776)2.12351698
93Agitation (HP:0000713)2.11555256
94Aplasia/Hypoplasia of the uvula (HP:0010293)2.11245577
95Excessive salivation (HP:0003781)2.10071730
96Mutism (HP:0002300)2.08903742
97Colitis (HP:0002583)2.08736211
98Clubbing of toes (HP:0100760)2.08560719
99Abnormal number of incisors (HP:0011064)2.07840008
100Delayed epiphyseal ossification (HP:0002663)2.03948582
101Lip pit (HP:0100267)2.03769588
102Ventricular tachycardia (HP:0004756)2.02943487
103Tinnitus (HP:0000360)2.02306786
104Supraventricular arrhythmia (HP:0005115)2.02249570
105Basal ganglia calcification (HP:0002135)2.02094148
106Sleep apnea (HP:0010535)2.01199137
107Short chin (HP:0000331)2.00845323
108Vaginal fistula (HP:0004320)1.98719989
109Pointed chin (HP:0000307)1.98354960
110Abnormality of the thoracic spine (HP:0100711)1.97175250
111Viral hepatitis (HP:0006562)1.97033467
112Depressed nasal tip (HP:0000437)1.96592233
113Supraventricular tachycardia (HP:0004755)1.95927375
114Cerebral ischemia (HP:0002637)1.94517515
115Abnormality of cells of the erythroid lineage (HP:0012130)1.94434704
116Morphological abnormality of the inner ear (HP:0011390)1.92007165
117Abnormality of the endocardium (HP:0004306)1.91944921
118Mesangial abnormality (HP:0001966)1.91658892
119Hypoplastic left heart (HP:0004383)1.91363068
120Optic nerve coloboma (HP:0000588)1.90419495
121Recurrent gram-negative bacterial infections (HP:0005420)1.90255799
122Palpebral edema (HP:0100540)1.89554428
123Thin ribs (HP:0000883)1.88299931
124Vertigo (HP:0002321)1.87912603
125Thoracic kyphosis (HP:0002942)1.86983753
126Limb dystonia (HP:0002451)1.86040916
127Truncus arteriosus (HP:0001660)1.84414614
128Cerebral hemorrhage (HP:0001342)1.84248705
129Rectal fistula (HP:0100590)1.83968834
130Rectovaginal fistula (HP:0000143)1.83968834
131Oligodontia (HP:0000677)1.83644092
132Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83291320
133Ectopic kidney (HP:0000086)1.82707325
134Progressive cerebellar ataxia (HP:0002073)1.82528133
135Failure to thrive in infancy (HP:0001531)1.82378675
136Choanal stenosis (HP:0000452)1.82169972
137Focal motor seizures (HP:0011153)1.80973844
138Elevated erythrocyte sedimentation rate (HP:0003565)1.80938568
139Abnormality of the prostate (HP:0008775)1.80433922
140Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80343214
141Hypoplasia of the brainstem (HP:0002365)1.80343214
142Pulmonary hypertension (HP:0002092)1.80245826
143Myotonia (HP:0002486)1.80237717
144Asymmetric growth (HP:0100555)1.79961909
145Encephalitis (HP:0002383)1.79547036
146Sparse lateral eyebrow (HP:0005338)1.78010397
147Gingivitis (HP:0000230)1.77283122
148Pigmentary retinal degeneration (HP:0001146)1.77271044
149Absent thumb (HP:0009777)1.76870285
150High anterior hairline (HP:0009890)1.76822507
151Maternal diabetes (HP:0009800)1.76821815
152Protruding tongue (HP:0010808)1.76816583
153Azoospermia (HP:0000027)1.76348859
154Febrile seizures (HP:0002373)1.75831154
155Shallow orbits (HP:0000586)1.75662296
156Autoimmune thrombocytopenia (HP:0001973)1.75586328
157Status epilepticus (HP:0002133)1.75583213
158Anterior segment dysgenesis (HP:0007700)1.73535010
159Abnormal pancreas size (HP:0012094)1.73189254
160Popliteal pterygium (HP:0009756)1.73026817
161Joint swelling (HP:0001386)1.72773417
162Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.71545830
163Short 4th metacarpal (HP:0010044)1.71545830
164Patellar aplasia (HP:0006443)1.70454785
165Abnormality of male internal genitalia (HP:0000022)1.69866534
166Abnormality of the pleura (HP:0002103)1.69108963
167Fair hair (HP:0002286)1.69024028
168Hip dysplasia (HP:0001385)1.68878308
169Precocious puberty (HP:0000826)1.68764660
170Chronic hepatic failure (HP:0100626)1.67894569
171Abnormality of the intervertebral disk (HP:0005108)1.67601153
172Epileptic encephalopathy (HP:0200134)1.67226450
173Chest pain (HP:0100749)1.67112493
174Neoplasm of the adrenal cortex (HP:0100641)1.66212371
175Septo-optic dysplasia (HP:0100842)1.66091705
176Amblyopia (HP:0000646)1.65995826
177Megalencephaly (HP:0001355)1.65689027
178Pancreatic fibrosis (HP:0100732)1.64963940
179Hypoplastic heart (HP:0001961)1.64406295
180Sudden death (HP:0001699)1.64318859
181Lipoatrophy (HP:0100578)1.63200016
182Meningocele (HP:0002435)1.63012002
183Abnormal biliary tract physiology (HP:0012439)1.62372283
184Bile duct proliferation (HP:0001408)1.62372283
185Broad phalanges of the hand (HP:0009768)1.62107040
186Coronal craniosynostosis (HP:0004440)1.60997847
187Tubular atrophy (HP:0000092)1.60232904
188Neurofibrillary tangles (HP:0002185)1.59775536
189Generalized tonic-clonic seizures (HP:0002069)1.59714102
190Enlarged kidneys (HP:0000105)1.58993838
191Broad thumb (HP:0011304)1.58926491

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.55310139
2SIK24.31773670
3TIE13.90316710
4KDR3.29900781
5EEF2K2.91700549
6WNK42.88644582
7SIK12.82006935
8TYK22.74701081
9IRAK42.61882642
10EPHB22.49101823
11JAK32.48796218
12CHUK2.45449115
13MAP3K132.38621309
14IKBKB2.36140021
15SIK32.29216708
16MARK22.25199398
17ICK2.23113965
18TAOK12.20741246
19ARAF2.13832052
20RPS6KA22.10508441
21IKBKE1.93356675
22WNK31.87727780
23TYRO31.86658048
24BMPR21.82164516
25JAK11.81022871
26TBK11.78894712
27TRIB31.72833710
28SGK21.63465382
29NEK91.55277176
30IRAK31.51348318
31TGFBR21.50036919
32RPS6KC11.49786708
33RPS6KL11.49786708
34MAPK131.48405848
35BMPR1B1.48027946
36BCR1.44912199
37RPS6KA61.39990290
38TGFBR11.39880847
39MAP3K61.39156779
40STK391.38160361
41CAMK1G1.35965873
42INSRR1.35174445
43CCNB11.34633787
44NTRK31.34520711
45EIF2AK21.32518931
46LATS11.27044781
47MAP2K71.26532626
48TAOK31.21073382
49PNCK1.21052044
50PRKAA21.20549938
51CAMK11.16934006
52ZAK1.14708421
53KIT1.14502323
54PKN11.08512519
55MAPK151.08351835
56TNIK1.05726775
57BRAF1.03403149
58STK38L0.98694797
59FGFR30.97694887
60CAMKK10.97280193
61STK110.95798461
62SGK30.95267370
63CDK90.94725284
64CDK80.92967630
65TXK0.92865719
66MUSK0.92617061
67YES10.92104638
68PLK40.91612374
69LATS20.87646027
70DAPK20.85756891
71DYRK20.85716994
72ERBB30.85029199
73GRK10.84719032
74MINK10.83392127
75STK240.82808923
76DYRK30.82776819
77BLK0.81377113
78SGK4940.81134285
79SGK2230.81134285
80PKN20.78859112
81HIPK20.78246937
82STK30.75267779
83NLK0.74374240
84JAK20.74374084
85MTOR0.74160024
86PRKCZ0.73463410
87CASK0.73268911
88MAP3K40.72591690
89DYRK1B0.71373996
90PAK60.70829465
91CAMK1D0.70290653
92PRKCG0.69170137
93NEK60.69063814
94NTRK20.68991873
95CDK50.66304141
96PTK2B0.66162873
97ERBB40.63098269
98MAP3K50.62806628
99IRAK10.62785235
100STK380.61130739
101MAP3K110.59787861
102KSR20.59483895
103PRKAA10.58525800
104NUAK10.58343711
105PDPK10.57886284
106OBSCN0.56799858
107SGK10.56703049
108CAMK40.55674195
109ILK0.55339894
110FGFR40.55313302
111VRK10.55097664
112RPS6KA40.54988232
113PTK60.53067093
114IRAK20.52241663
115RPS6KA10.51585743
116PLK20.51234491
117BRD40.50250402
118MARK30.49831501
119MARK10.49752445
120PIM10.49544708
121DMPK0.49420220
122PAK30.49326684
123MELK0.48947615
124AKT30.48639000
125CDC42BPA0.48554467
126FLT30.47931740
127EPHA30.47601349
128MAP3K30.47265499
129DYRK1A0.46308349
130BMX0.46246740
131RET0.45863782
132PINK10.45333700
133ABL20.44963269
134ACVR1B0.44778853
135MAP3K100.44744087
136RIPK10.44334070
137TTN0.42955578
138RPS6KB10.42884300
139STK40.42872012
140WNK10.42717819
141RIPK40.41972121
142PHKG20.41855264
143PHKG10.41855264
144RPS6KB20.41807493
145MAPK80.40360892
146AKT10.40305432
147SYK0.39940004
148GRK70.39841904
149TEC0.39155505
150CHEK20.38963485
151MAPK120.38450805
152EPHA40.38276566
153FES0.37409912
154NTRK10.36687091
155KSR10.35722833
156CSNK1G20.35361977
157ABL10.34990929
158TRPM70.34693210
159CDK11A0.34514505
160MAPKAPK30.34313224
161ADRBK20.32926957
162MAPKAPK50.32620525
163MOS0.32454900
164MAP3K20.32068716
165MAP3K90.32053886
166MYLK0.31639095
167CSNK1D0.31594482
168PRKCE0.31075842

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.41422310
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.74579886
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.69890541
4Graft-versus-host disease_Homo sapiens_hsa053322.56378077
5Autoimmune thyroid disease_Homo sapiens_hsa053202.47095889
6Cocaine addiction_Homo sapiens_hsa050302.14261421
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.12134001
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.06807178
9TNF signaling pathway_Homo sapiens_hsa046682.00618232
10Leishmaniasis_Homo sapiens_hsa051401.96554155
11Cholinergic synapse_Homo sapiens_hsa047251.91916212
12Viral myocarditis_Homo sapiens_hsa054161.90727157
13Cardiac muscle contraction_Homo sapiens_hsa042601.84990565
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.84817559
15Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.84609974
16Measles_Homo sapiens_hsa051621.83042576
17Toxoplasmosis_Homo sapiens_hsa051451.77135174
18Osteoclast differentiation_Homo sapiens_hsa043801.75136905
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.75023493
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74994222
21Herpes simplex infection_Homo sapiens_hsa051681.72997080
22Influenza A_Homo sapiens_hsa051641.65939443
23Sulfur relay system_Homo sapiens_hsa041221.62313911
24Type I diabetes mellitus_Homo sapiens_hsa049401.60630831
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56015694
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.53700297
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.52306126
28Dorso-ventral axis formation_Homo sapiens_hsa043201.47357247
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.46752743
30Chemokine signaling pathway_Homo sapiens_hsa040621.45899426
31VEGF signaling pathway_Homo sapiens_hsa043701.45547527
32Phototransduction_Homo sapiens_hsa047441.43887820
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.42248622
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41979486
35Prolactin signaling pathway_Homo sapiens_hsa049171.41665962
36African trypanosomiasis_Homo sapiens_hsa051431.41022142
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40942215
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.40766842
39Apoptosis_Homo sapiens_hsa042101.38692414
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36915683
41Dopaminergic synapse_Homo sapiens_hsa047281.34972056
42Insulin secretion_Homo sapiens_hsa049111.31786286
43Basal cell carcinoma_Homo sapiens_hsa052171.31576945
44Ovarian steroidogenesis_Homo sapiens_hsa049131.28160973
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.27448548
46Long-term potentiation_Homo sapiens_hsa047201.26774389
47Hippo signaling pathway_Homo sapiens_hsa043901.23874531
48Steroid biosynthesis_Homo sapiens_hsa001001.21888179
49Small cell lung cancer_Homo sapiens_hsa052221.18930973
50Melanogenesis_Homo sapiens_hsa049161.18866302
51Circadian rhythm_Homo sapiens_hsa047101.18767533
52GABAergic synapse_Homo sapiens_hsa047271.18360114
53Gastric acid secretion_Homo sapiens_hsa049711.17019041
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16654213
55Long-term depression_Homo sapiens_hsa047301.16165683
56Synaptic vesicle cycle_Homo sapiens_hsa047211.13952607
57Hedgehog signaling pathway_Homo sapiens_hsa043401.12372378
58AMPK signaling pathway_Homo sapiens_hsa041521.10412268
59Lysine degradation_Homo sapiens_hsa003101.10101169
60Rap1 signaling pathway_Homo sapiens_hsa040151.07682058
61Malaria_Homo sapiens_hsa051441.07037644
62Dilated cardiomyopathy_Homo sapiens_hsa054141.05577726
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05289612
64ErbB signaling pathway_Homo sapiens_hsa040121.03893913
65Arginine biosynthesis_Homo sapiens_hsa002201.01807652
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00783719
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99720541
68Prion diseases_Homo sapiens_hsa050200.98888972
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.98581651
70Calcium signaling pathway_Homo sapiens_hsa040200.97933891
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95734040
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.95234372
73Rheumatoid arthritis_Homo sapiens_hsa053230.94863365
74Nicotine addiction_Homo sapiens_hsa050330.94760490
75Olfactory transduction_Homo sapiens_hsa047400.93268642
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92959629
77GnRH signaling pathway_Homo sapiens_hsa049120.92802973
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92609211
79Legionellosis_Homo sapiens_hsa051340.92179385
80Pertussis_Homo sapiens_hsa051330.91834455
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91714096
82Tuberculosis_Homo sapiens_hsa051520.90593395
83Insulin signaling pathway_Homo sapiens_hsa049100.90312221
84Gap junction_Homo sapiens_hsa045400.87271977
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86141267
86MAPK signaling pathway_Homo sapiens_hsa040100.86071995
87Renal cell carcinoma_Homo sapiens_hsa052110.84953580
88FoxO signaling pathway_Homo sapiens_hsa040680.84551986
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.83933999
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83676507
91Amphetamine addiction_Homo sapiens_hsa050310.82505530
92Ribosome_Homo sapiens_hsa030100.80977630
93Hepatitis B_Homo sapiens_hsa051610.80643055
94Pancreatic cancer_Homo sapiens_hsa052120.80580164
95Notch signaling pathway_Homo sapiens_hsa043300.80535107
96Estrogen signaling pathway_Homo sapiens_hsa049150.80521604
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80165450
98Wnt signaling pathway_Homo sapiens_hsa043100.79550433
99Chronic myeloid leukemia_Homo sapiens_hsa052200.78248549
100B cell receptor signaling pathway_Homo sapiens_hsa046620.77235381
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76868233
102Shigellosis_Homo sapiens_hsa051310.76554563
103Antigen processing and presentation_Homo sapiens_hsa046120.75947842
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75454870
105Asthma_Homo sapiens_hsa053100.74117367
106Glutamatergic synapse_Homo sapiens_hsa047240.73501635
107p53 signaling pathway_Homo sapiens_hsa041150.73422372
108MicroRNAs in cancer_Homo sapiens_hsa052060.72685851
109Type II diabetes mellitus_Homo sapiens_hsa049300.72411297
110Hepatitis C_Homo sapiens_hsa051600.71659093
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71612252
112Epstein-Barr virus infection_Homo sapiens_hsa051690.71110364
113Adherens junction_Homo sapiens_hsa045200.71080248
114HTLV-I infection_Homo sapiens_hsa051660.70850618
115Alcoholism_Homo sapiens_hsa050340.70395843
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69140784
117Glioma_Homo sapiens_hsa052140.68976765
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67302992
119Taste transduction_Homo sapiens_hsa047420.66079646
120mTOR signaling pathway_Homo sapiens_hsa041500.65700289
121Primary immunodeficiency_Homo sapiens_hsa053400.65420448
122cAMP signaling pathway_Homo sapiens_hsa040240.65297879
123Glycosaminoglycan degradation_Homo sapiens_hsa005310.65069314
124Renin secretion_Homo sapiens_hsa049240.64475983
125Acute myeloid leukemia_Homo sapiens_hsa052210.63795271
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63544119
127Salmonella infection_Homo sapiens_hsa051320.63037721
128Insulin resistance_Homo sapiens_hsa049310.62724430
129Staphylococcus aureus infection_Homo sapiens_hsa051500.62028801
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60917273
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60723235
132Melanoma_Homo sapiens_hsa052180.59588493
133Serotonergic synapse_Homo sapiens_hsa047260.59460693
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.58376323
135Choline metabolism in cancer_Homo sapiens_hsa052310.57783667
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57590294
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.57448023
138Alzheimers disease_Homo sapiens_hsa050100.57434316
139Tight junction_Homo sapiens_hsa045300.56067153
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.55837713
141Oxytocin signaling pathway_Homo sapiens_hsa049210.55566160
142Morphine addiction_Homo sapiens_hsa050320.55090004
143Phospholipase D signaling pathway_Homo sapiens_hsa040720.54913718
144Endometrial cancer_Homo sapiens_hsa052130.54577689
145Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54063764
146Ras signaling pathway_Homo sapiens_hsa040140.52851297
147T cell receptor signaling pathway_Homo sapiens_hsa046600.52750162
148Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51270198
149Salivary secretion_Homo sapiens_hsa049700.51124122
150Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51076907
151Pathways in cancer_Homo sapiens_hsa052000.50760269
152Colorectal cancer_Homo sapiens_hsa052100.50694102
153Axon guidance_Homo sapiens_hsa043600.50198469
154Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49646571
155RNA degradation_Homo sapiens_hsa030180.49628998
156Platelet activation_Homo sapiens_hsa046110.48520772
157Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48493093
158Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48365516
159Bile secretion_Homo sapiens_hsa049760.48313650
160Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48276016
161TGF-beta signaling pathway_Homo sapiens_hsa043500.48003507
162Circadian entrainment_Homo sapiens_hsa047130.47581333
163Amoebiasis_Homo sapiens_hsa051460.46604889
164Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46015063
165Inositol phosphate metabolism_Homo sapiens_hsa005620.44664048
166Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44628458
167Focal adhesion_Homo sapiens_hsa045100.44141075
168Cell cycle_Homo sapiens_hsa041100.43969381

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