ZBTB44

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.80365998
2mitotic sister chromatid cohesion (GO:0007064)5.54225616
3nuclear pore complex assembly (GO:0051292)5.26542116
4positive regulation of cellular amine metabolic process (GO:0033240)5.23425859
5regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033395.05843430
6viral transcription (GO:0019083)4.95691384
7translational termination (GO:0006415)4.78823011
8ribosomal small subunit biogenesis (GO:0042274)4.76883870
9mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.70226384
10nuclear pore organization (GO:0006999)4.69043135
11ribosomal small subunit assembly (GO:0000028)4.67887227
12telomere maintenance via semi-conservative replication (GO:0032201)4.66708215
13nephron tubule formation (GO:0072079)4.59401072
14lymphoid progenitor cell differentiation (GO:0002320)4.58272308
15GDP-mannose metabolic process (GO:0019673)4.54065807
16negative regulation of metanephros development (GO:0072217)4.52592878
17peptidyl-threonine dephosphorylation (GO:0035970)4.51914595
18respiratory chain complex IV assembly (GO:0008535)4.42467884
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.41462161
20regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.36281018
21cotranslational protein targeting to membrane (GO:0006613)4.33971876
22pattern specification involved in kidney development (GO:0061004)4.29403245
23negative regulation of DNA-dependent DNA replication (GO:2000104)4.29110308
24protein targeting to ER (GO:0045047)4.29008105
25negative regulation of transcription by competitive promoter binding (GO:0010944)4.28284365
26facial nerve structural organization (GO:0021612)4.24478050
27negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.24044823
28negative regulation of translation, ncRNA-mediated (GO:0040033)4.24044823
29regulation of translation, ncRNA-mediated (GO:0045974)4.24044823
30pre-miRNA processing (GO:0031054)4.18852361
31regulation of histone H3-K9 methylation (GO:0051570)4.09311417
32negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)4.08570603
33protein localization to endoplasmic reticulum (GO:0070972)4.07843281
34establishment of protein localization to endoplasmic reticulum (GO:0072599)4.05815822
35generation of neurons (GO:0048699)4.02212387
36mannosylation (GO:0097502)3.99577500
37mesonephros development (GO:0001823)3.98591275
38regulation of apoptotic process involved in morphogenesis (GO:1902337)3.88533252
39telomere maintenance via recombination (GO:0000722)3.86484718
40translational elongation (GO:0006414)3.85457400
41endothelium development (GO:0003158)3.84780074
42regulation of pigment cell differentiation (GO:0050932)3.82631773
43DNA replication initiation (GO:0006270)3.81894851
44C-terminal protein lipidation (GO:0006501)3.77350985
45postsynaptic membrane organization (GO:0001941)3.76232064
46GPI anchor biosynthetic process (GO:0006506)3.74673016
47chromatin remodeling at centromere (GO:0031055)3.68027071
48maturation of SSU-rRNA (GO:0030490)3.67206860
49urogenital system development (GO:0001655)3.66868134
50DNA strand elongation involved in DNA replication (GO:0006271)3.66185091
51genitalia morphogenesis (GO:0035112)3.66095043
52histone exchange (GO:0043486)3.65963320
53monoubiquitinated protein deubiquitination (GO:0035520)3.65041054
54positive regulation of hormone metabolic process (GO:0032352)3.61839353
55synapsis (GO:0007129)3.58282839
56positive regulation of glycoprotein biosynthetic process (GO:0010560)3.57924129
57negative regulation of myotube differentiation (GO:0010832)3.57322825
58regulation of DNA endoreduplication (GO:0032875)3.56900540
59regulation of meiosis I (GO:0060631)3.54942589
60negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.54245267
61CENP-A containing nucleosome assembly (GO:0034080)3.54110399
62sister chromatid cohesion (GO:0007062)3.51501704
63regulation of nuclear cell cycle DNA replication (GO:0033262)3.50914526
64platelet dense granule organization (GO:0060155)3.50420178
65DNA strand elongation (GO:0022616)3.50157830
66ribosomal large subunit biogenesis (GO:0042273)3.50077618
67pore complex assembly (GO:0046931)3.49848817
68negative regulation of DNA repair (GO:0045738)3.49791869
69regulation of centriole replication (GO:0046599)3.48015767
70viral life cycle (GO:0019058)3.44275328
71phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.41682751
72translational initiation (GO:0006413)3.40997640
73cranial nerve morphogenesis (GO:0021602)3.40656166
74cellular protein complex disassembly (GO:0043624)3.40112782
75regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.39492136
76regulation of mitotic spindle checkpoint (GO:1903504)3.39492136
77positive regulation of protein export from nucleus (GO:0046827)3.39064910
78nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.38608993
79metanephric nephron tubule development (GO:0072234)3.36636349
80metanephric tubule development (GO:0072170)3.36636349
81dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.36592719
82negative regulation of fibroblast apoptotic process (GO:2000270)3.33480244
83regulation of gene silencing by RNA (GO:0060966)3.33106246
84regulation of posttranscriptional gene silencing (GO:0060147)3.33106246
85regulation of gene silencing by miRNA (GO:0060964)3.33106246
86N-acetylneuraminate metabolic process (GO:0006054)3.32836407
87amino sugar catabolic process (GO:0046348)3.32716690
88ribosome assembly (GO:0042255)3.32135923
89presynaptic membrane assembly (GO:0097105)3.31951689
90androgen biosynthetic process (GO:0006702)3.31900147
91regulation of helicase activity (GO:0051095)3.31206942
92positive regulation of histone H3-K4 methylation (GO:0051571)3.31163674
93negative regulation of mitotic sister chromatid separation (GO:2000816)3.31151226
94negative regulation of sister chromatid segregation (GO:0033046)3.31151226
95negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.31151226
96negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.31151226
97negative regulation of mitotic sister chromatid segregation (GO:0033048)3.31151226
98positive regulation of histone methylation (GO:0031062)3.29962913
99mesenchymal to epithelial transition (GO:0060231)3.29280374
100GMP metabolic process (GO:0046037)3.28304277
101mitotic recombination (GO:0006312)3.28111789
102response to interferon-alpha (GO:0035455)3.26804136
103histone mRNA catabolic process (GO:0071044)3.26591739
104negative regulation of DNA recombination (GO:0045910)3.23540026
105response to folic acid (GO:0051593)3.23092444
106RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.21443457
107non-recombinational repair (GO:0000726)3.20317589
108double-strand break repair via nonhomologous end joining (GO:0006303)3.20317589
109DNA double-strand break processing (GO:0000729)3.20218479
110negative regulation of chromosome segregation (GO:0051985)3.20168679
111regulation of mitotic sister chromatid separation (GO:0010965)3.19496562
112regulation of mitotic sister chromatid segregation (GO:0033047)3.19496562
113regulation of sister chromatid segregation (GO:0033045)3.19496562
114mitotic spindle checkpoint (GO:0071174)3.18973599
115mitotic G2/M transition checkpoint (GO:0044818)3.18273915
116somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.18255524
117isotype switching (GO:0045190)3.18255524
118somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.18255524
119pseudouridine synthesis (GO:0001522)3.16481703
120cytochrome complex assembly (GO:0017004)3.16276749
121positive regulation of gluconeogenesis (GO:0045722)3.16039160
122telomere maintenance via telomere lengthening (GO:0010833)3.15436221
123GPI anchor metabolic process (GO:0006505)3.15314852
124C-terminal protein amino acid modification (GO:0018410)3.15129123
125positive regulation of metanephros development (GO:0072216)3.14608690
126regulation of mitotic metaphase/anaphase transition (GO:0030071)3.14250762
127regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.14250762
128interkinetic nuclear migration (GO:0022027)3.12899535
129protein heterotetramerization (GO:0051290)3.10372558
130somatic recombination of immunoglobulin gene segments (GO:0016447)3.10295853
131IMP metabolic process (GO:0046040)3.10171453
132regulation of type B pancreatic cell apoptotic process (GO:2000674)3.09348650
133spindle checkpoint (GO:0031577)3.09200292
134L-fucose catabolic process (GO:0042355)3.07665379
135fucose catabolic process (GO:0019317)3.07665379
136L-fucose metabolic process (GO:0042354)3.07665379
137NLS-bearing protein import into nucleus (GO:0006607)3.06924500
138regulation of chromatin silencing (GO:0031935)3.06372500
139somatic diversification of immune receptors via somatic mutation (GO:0002566)3.04047691
140somatic hypermutation of immunoglobulin genes (GO:0016446)3.04047691
141somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.03523521
142somatic cell DNA recombination (GO:0016444)3.03523521
143neural tube formation (GO:0001841)3.00450347
144cranial nerve structural organization (GO:0021604)2.99781006
145telomere maintenance via telomerase (GO:0007004)2.97695674
146IMP biosynthetic process (GO:0006188)2.97211323
147mitotic spindle assembly checkpoint (GO:0007094)2.96858898
148nephron epithelium development (GO:0072009)2.96834064
149protein complex disassembly (GO:0043241)2.94865828
150intra-S DNA damage checkpoint (GO:0031573)2.94846472
151cytoplasmic mRNA processing body assembly (GO:0033962)2.93998229
152deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.92718303
153proteasome assembly (GO:0043248)2.91054306
154spindle assembly checkpoint (GO:0071173)2.90391857
155mitotic G2 DNA damage checkpoint (GO:0007095)2.89093808
156thyroid gland development (GO:0030878)2.88851236
157metanephric nephron epithelium development (GO:0072243)2.88581391
158regulation of mesenchymal cell apoptotic process (GO:2001053)2.88450974
159response to X-ray (GO:0010165)2.88280155
160DNA replication-independent nucleosome organization (GO:0034724)2.87766200
161DNA replication-independent nucleosome assembly (GO:0006336)2.87766200
162somatic diversification of immune receptors (GO:0002200)2.85070771
163antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.84651669
164regulation of centrosome duplication (GO:0010824)2.84623699
165metanephric epithelium development (GO:0072207)2.84119022
166somatic diversification of immunoglobulins (GO:0016445)2.83964469
167histone-serine phosphorylation (GO:0035404)2.83153200
168definitive hemopoiesis (GO:0060216)2.82782244
169phospholipid scrambling (GO:0017121)2.81432375
170negative regulation of erythrocyte differentiation (GO:0045647)2.80075644
171viral genome replication (GO:0019079)2.80003415
172V(D)J recombination (GO:0033151)2.79911538
173omega-hydroxylase P450 pathway (GO:0097267)2.79715656
174specification of organ identity (GO:0010092)2.79086652
175single strand break repair (GO:0000012)2.78090626
176regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.77602477
177positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.77602477
178DNA ligation (GO:0006266)2.75441769
179translation (GO:0006412)2.75372123
180macromolecular complex disassembly (GO:0032984)2.75355783
181regulation of gene silencing (GO:0060968)2.75344857
182ribonucleoprotein complex biogenesis (GO:0022613)2.75158861
183negative regulation of smooth muscle cell differentiation (GO:0051151)2.74327378
184determination of adult lifespan (GO:0008340)2.72173753
185N-terminal protein amino acid acetylation (GO:0006474)2.69799313
186regulation of chromosome segregation (GO:0051983)2.68088303
187regulation of establishment of cell polarity (GO:2000114)2.65443358
188DNA unwinding involved in DNA replication (GO:0006268)2.62550873
189microtubule anchoring (GO:0034453)2.62454717
190DNA replication-dependent nucleosome organization (GO:0034723)2.58434326
191DNA replication-dependent nucleosome assembly (GO:0006335)2.58434326
192histone mRNA metabolic process (GO:0008334)2.57962642
193positive regulation of SMAD protein import into nucleus (GO:0060391)2.57523418
194establishment of protein localization to Golgi (GO:0072600)2.57342306
195regulation of centrosome cycle (GO:0046605)2.56531449
196chromatin silencing (GO:0006342)2.55740631
197protein K63-linked deubiquitination (GO:0070536)2.53167359
198regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.52326184
199positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.52326184

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.86710578
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.40106220
3E2F7_22180533_ChIP-Seq_HELA_Human5.29124139
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.96035239
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.46092909
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.04748463
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.04327791
8SCL_19346495_ChIP-Seq_HPC-7_Human3.03983322
9NOTCH1_21737748_ChIP-Seq_TLL_Human3.02716824
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.82674540
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.71503498
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.59795795
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.58484235
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.58219131
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.57412029
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.52540205
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.50980841
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.42950017
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.40791117
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.37940406
21* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.35542602
22EWS_26573619_Chip-Seq_HEK293_Human2.34642504
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.33782689
24IRF1_19129219_ChIP-ChIP_H3396_Human2.33583670
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.28741323
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.25507960
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.23563306
28* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18998798
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.18216301
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.16134882
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.11391706
32* ERG_20887958_ChIP-Seq_HPC-7_Mouse2.07563328
33E2F4_17652178_ChIP-ChIP_JURKAT_Human2.07467911
34GBX2_23144817_ChIP-Seq_PC3_Human2.07459048
35* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.04083756
36EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.99870441
37IGF1R_20145208_ChIP-Seq_DFB_Human1.98205151
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.97789004
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.95002673
40P300_19829295_ChIP-Seq_ESCs_Human1.93762563
41VDR_23849224_ChIP-Seq_CD4+_Human1.88864424
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.88503839
43VDR_22108803_ChIP-Seq_LS180_Human1.84993695
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.84375915
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.82312934
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81344418
47GATA1_22025678_ChIP-Seq_K562_Human1.80181380
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78049470
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.76837731
50* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.72092765
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.67283988
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66351907
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66082794
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64758552
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62406663
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.62336703
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.62089976
58FOXP3_21729870_ChIP-Seq_TREG_Human1.60600583
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59504912
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59473357
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.57862826
62SPI1_23547873_ChIP-Seq_NB4_Human1.57316972
63MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56473031
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56455835
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.55263587
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55173889
67FOXM1_23109430_ChIP-Seq_U2OS_Human1.54110179
68* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50529704
69BP1_19119308_ChIP-ChIP_Hs578T_Human1.47298737
70KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.46197221
71KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.46197221
72KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.46197221
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45058333
74ZNF274_21170338_ChIP-Seq_K562_Hela1.43512117
75STAT3_23295773_ChIP-Seq_U87_Human1.38296591
76FOXM1_26456572_ChIP-Seq_MCF-7_Human1.37581522
77ER_23166858_ChIP-Seq_MCF-7_Human1.37353154
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36229505
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35232771
80SMAD4_21799915_ChIP-Seq_A2780_Human1.34989059
81ELK1_19687146_ChIP-ChIP_HELA_Human1.33388798
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32914170
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32387389
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.32230301
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29978731
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29581058
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29206327
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28060377
89TCF4_23295773_ChIP-Seq_U87_Human1.27428804
90MYC_18940864_ChIP-ChIP_HL60_Human1.27236221
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27229002
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26446655
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26446655
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26086120
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.26063058
96HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.25492275
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.25190323
98TTF2_22483619_ChIP-Seq_HELA_Human1.24946714
99* SMAD3_21741376_ChIP-Seq_EPCs_Human1.24631646
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23076978
101RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22132853
102CBP_20019798_ChIP-Seq_JUKART_Human1.21964681
103IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21964681
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21390817
105STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21260073
106* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20235477
107TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20192950
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19975098
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.19715710
110E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18231893
111E2F1_18555785_Chip-Seq_ESCs_Mouse1.18037345
112RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.17971968
113MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16103193
114AR_21572438_ChIP-Seq_LNCaP_Human1.15558679
115GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13826660
116DCP1A_22483619_ChIP-Seq_HELA_Human1.13756813
117CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13072242
118FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.11257250
119CRX_20693478_ChIP-Seq_RETINA_Mouse1.10892199
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10592220
121TP63_19390658_ChIP-ChIP_HaCaT_Human1.10472884
122* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09930097
123PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09692995
124CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07468763
125TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06293714
126SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05684886
127VDR_24763502_ChIP-Seq_THP-1_Human1.05546096
128FLI1_21867929_ChIP-Seq_TH2_Mouse1.05507335
129OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05418047
130ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05208190
131P53_22387025_ChIP-Seq_ESCs_Mouse1.05004955
132VDR_21846776_ChIP-Seq_THP-1_Human1.04478954
133CMYC_18555785_Chip-Seq_ESCs_Mouse1.04155111
134KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03970073
135YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02882143
136SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02755170
137XRN2_22483619_ChIP-Seq_HELA_Human1.02571159
138NANOG_16153702_ChIP-ChIP_HESCs_Human1.02382931
139GATA3_21867929_ChIP-Seq_CD8_Mouse1.02150425
140CDX2_22108803_ChIP-Seq_LS180_Human1.01992227
141TCF4_22108803_ChIP-Seq_LS180_Human1.01803181
142EZH2_27294783_Chip-Seq_NPCs_Mouse1.01472703
143E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00556275
144* RUNX2_22187159_ChIP-Seq_PCA_Human1.00173241
145AR_21909140_ChIP-Seq_LNCAP_Human0.99623125
146AR_25329375_ChIP-Seq_VCAP_Human0.98454778
147* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98223089
148SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97981939
149GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97755589
150CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97738425
151BCAT_22108803_ChIP-Seq_LS180_Human0.97345996
152POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97286160
153SALL4_22934838_ChIP-ChIP_CD34+_Human0.96723756
154THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95613540
155PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95420843
156SOX2_19829295_ChIP-Seq_ESCs_Human0.95079409
157NANOG_19829295_ChIP-Seq_ESCs_Human0.95079409
158PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95001445
159GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94143324
160RUNX1_27457419_Chip-Seq_LIVER_Mouse0.92641862
161RUNX1_22412390_ChIP-Seq_EML_Mouse0.91589726
162CIITA_25753668_ChIP-Seq_RAJI_Human0.91454665
163MYB_26560356_Chip-Seq_TH1_Human0.89769650
164E2F1_21310950_ChIP-Seq_MCF-7_Human0.88359313
165NELFA_20434984_ChIP-Seq_ESCs_Mouse0.87419245
166PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84913848
167* MYB_26560356_Chip-Seq_TH2_Human0.83770451
168ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83226867
169STAT3_18555785_Chip-Seq_ESCs_Mouse0.82598360
170PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80034806
171P300_18555785_Chip-Seq_ESCs_Mouse0.78319155
172SUZ12_18555785_Chip-Seq_ESCs_Mouse0.77764973
173TAF15_26573619_Chip-Seq_HEK293_Human0.77707693
174OCT4_18555785_Chip-Seq_ESCs_Mouse0.77385962
175LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.75843461
176KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74957018
177FUS_26573619_Chip-Seq_HEK293_Human0.74609409

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.76700148
2MP0005409_darkened_coat_color4.63577413
3MP0001188_hyperpigmentation4.47330004
4MP0008877_abnormal_DNA_methylation4.42594994
5MP0005174_abnormal_tail_pigmentation3.97168538
6MP0003136_yellow_coat_color3.89816825
7MP0006292_abnormal_olfactory_placode3.63093322
8MP0003890_abnormal_embryonic-extraembry2.95384502
9MP0000015_abnormal_ear_pigmentation2.93433498
10MP0003724_increased_susceptibility_to2.92000675
11MP0005075_abnormal_melanosome_morpholog2.87218251
12MP0004381_abnormal_hair_follicle2.64913510
13MP0003646_muscle_fatigue2.52725922
14MP0003567_abnormal_fetal_cardiomyocyte2.51793545
15MP0002396_abnormal_hematopoietic_system2.44711932
16MP0001986_abnormal_taste_sensitivity2.39566864
17MP0004145_abnormal_muscle_electrophysio2.27425615
18MP0003787_abnormal_imprinting2.26569718
19MP0002095_abnormal_skin_pigmentation2.24746709
20MP0003941_abnormal_skin_development2.24448137
21MP0010352_gastrointestinal_tract_polyps2.22247422
22MP0003111_abnormal_nucleus_morphology2.06534299
23MP0000490_abnormal_crypts_of2.05213246
24MP0002254_reproductive_system_inflammat2.03871517
25MP0003868_abnormal_feces_composition2.02284619
26MP0002876_abnormal_thyroid_physiology1.94829815
27MP0000681_abnormal_thyroid_gland1.84505115
28MP0008058_abnormal_DNA_repair1.78942462
29MP0000569_abnormal_digit_pigmentation1.76537611
30MP0009672_abnormal_birth_weight1.72580221
31MP0004147_increased_porphyrin_level1.68050830
32MP0001835_abnormal_antigen_presentation1.65245336
33MP0003763_abnormal_thymus_physiology1.64796461
34MP0008260_abnormal_autophagy1.63985757
35MP0009703_decreased_birth_body1.62040075
36MP0005671_abnormal_response_to1.59889255
37MP0000372_irregular_coat_pigmentation1.56502653
38MP0003879_abnormal_hair_cell1.55728541
39MP0004036_abnormal_muscle_relaxation1.55184959
40MP0009785_altered_susceptibility_to1.54829294
41MP0008057_abnormal_DNA_replication1.49755851
42MP0004084_abnormal_cardiac_muscle1.45235070
43MP0003303_peritoneal_inflammation1.44672856
44MP0000465_gastrointestinal_hemorrhage1.43938098
45MP0002177_abnormal_outer_ear1.42656863
46MP0003693_abnormal_embryo_hatching1.42017964
47MP0003880_abnormal_central_pattern1.40188346
48MP0010094_abnormal_chromosome_stability1.39646837
49MP0000049_abnormal_middle_ear1.37275518
50MP0003938_abnormal_ear_development1.36979754
51MP0004215_abnormal_myocardial_fiber1.36495427
52MP0003943_abnormal_hepatobiliary_system1.34935351
53MP0001177_atelectasis1.32988417
54MP0010307_abnormal_tumor_latency1.30157140
55MP0005025_abnormal_response_to1.28563266
56MP0000631_abnormal_neuroendocrine_gland1.26227447
57MP0001730_embryonic_growth_arrest1.25926710
58MP0003011_delayed_dark_adaptation1.25812234
59MP0002088_abnormal_embryonic_growth/wei1.25592221
60MP0001853_heart_inflammation1.25454529
61MP0001672_abnormal_embryogenesis/_devel1.24690403
62MP0005380_embryogenesis_phenotype1.24690403
63MP0000350_abnormal_cell_proliferation1.22381157
64MP0009333_abnormal_splenocyte_physiolog1.21595424
65MP0003984_embryonic_growth_retardation1.21184553
66MP0003786_premature_aging1.20642486
67MP0003221_abnormal_cardiomyocyte_apopto1.20267941
68MP0001545_abnormal_hematopoietic_system1.18873223
69MP0005397_hematopoietic_system_phenotyp1.18873223
70MP0003121_genomic_imprinting1.17554052
71MP0002102_abnormal_ear_morphology1.17090836
72MP0003195_calcinosis1.15889237
73MP0002148_abnormal_hypersensitivity_rea1.13807977
74MP0000613_abnormal_salivary_gland1.12060506
75MP0002751_abnormal_autonomic_nervous1.11642993
76MP0000685_abnormal_immune_system1.10801929
77MP0002398_abnormal_bone_marrow1.09976571
78MP0009697_abnormal_copulation1.09107919
79MP0005000_abnormal_immune_tolerance1.08699969
80MP0002106_abnormal_muscle_physiology1.08622100
81MP0000689_abnormal_spleen_morphology1.07760705
82MP0000703_abnormal_thymus_morphology1.07018350
83MP0001697_abnormal_embryo_size1.05893872
84MP0004197_abnormal_fetal_growth/weight/1.05645217
85MP0002723_abnormal_immune_serum1.04298552
86MP0002166_altered_tumor_susceptibility1.04062340
87MP0001800_abnormal_humoral_immune1.03587957
88MP0002638_abnormal_pupillary_reflex1.03576767
89MP0002420_abnormal_adaptive_immunity1.03256346
90MP0003937_abnormal_limbs/digits/tail_de1.02891425
91MP0010678_abnormal_skin_adnexa1.01938372
92MP0001819_abnormal_immune_cell1.00622561
93MP0000749_muscle_degeneration0.99902887
94MP0002084_abnormal_developmental_patter0.99465205
95MP0003436_decreased_susceptibility_to0.99416518
96MP0002938_white_spotting0.98663575
97MP0001293_anophthalmia0.98279062
98MP0000716_abnormal_immune_system0.97604812
99MP0002086_abnormal_extraembryonic_tissu0.97596572
100MP0002075_abnormal_coat/hair_pigmentati0.96234942
101MP0003806_abnormal_nucleotide_metabolis0.96049548
102MP0002722_abnormal_immune_system0.95628099
103MP0004484_altered_response_of0.95195765
104MP0004264_abnormal_extraembryonic_tissu0.94101701
105MP0001661_extended_life_span0.93745172
106MP0000653_abnormal_sex_gland0.93698425
107MP0005220_abnormal_exocrine_pancreas0.93012105
108MP0004185_abnormal_adipocyte_glucose0.92749671
109MP0004043_abnormal_pH_regulation0.92319768
110MP0002419_abnormal_innate_immunity0.92131254
111MP0008007_abnormal_cellular_replicative0.91859240
112MP0002210_abnormal_sex_determination0.90778318
113MP0002249_abnormal_larynx_morphology0.90018514
114MP0001485_abnormal_pinna_reflex0.89662259
115MP0003828_pulmonary_edema0.89313956
116MP0002160_abnormal_reproductive_system0.89216489
117MP0005369_muscle_phenotype0.88489579
118MP0000383_abnormal_hair_follicle0.88442454
119MP0010630_abnormal_cardiac_muscle0.88378925
120MP0008995_early_reproductive_senescence0.87283371
121MP0000427_abnormal_hair_cycle0.86786204
122MP0003866_abnormal_defecation0.86405155
123MP0004130_abnormal_muscle_cell0.86161338
124MP0002452_abnormal_antigen_presenting0.86136564
125MP0002429_abnormal_blood_cell0.85618560
126MP0010155_abnormal_intestine_physiology0.85313432
127MP0004808_abnormal_hematopoietic_stem0.85158880
128MP0002085_abnormal_embryonic_tissue0.82418072
129MP0005620_abnormal_muscle_contractility0.81900228
130MP0002132_abnormal_respiratory_system0.81871519
131MP0001873_stomach_inflammation0.81087190
132MP0002006_tumorigenesis0.80056406
133MP0003656_abnormal_erythrocyte_physiolo0.78227996
134MP0004087_abnormal_muscle_fiber0.78003113
135MP0006035_abnormal_mitochondrial_morpho0.77677236
136MP0001929_abnormal_gametogenesis0.77163448
137MP0003718_maternal_effect0.77140685
138MP0005395_other_phenotype0.76572153
139MP0002269_muscular_atrophy0.76044805
140MP0001663_abnormal_digestive_system0.75822564
141MP0002019_abnormal_tumor_incidence0.75212122
142MP0004142_abnormal_muscle_tone0.74938055
143MP0002009_preneoplasia0.74840519
144MP0001984_abnormal_olfaction0.74477207
145MP0002080_prenatal_lethality0.74266100
146MP0010234_abnormal_vibrissa_follicle0.73747070
147MP0004957_abnormal_blastocyst_morpholog0.71753269
148MP0001286_abnormal_eye_development0.71201822
149MP0001186_pigmentation_phenotype0.70962140
150MP0005464_abnormal_platelet_physiology0.70719110
151MP0000266_abnormal_heart_morphology0.69565786
152MP0001145_abnormal_male_reproductive0.68665796
153MP0003123_paternal_imprinting0.67498911
154MP0003119_abnormal_digestive_system0.67208423
155MP0003698_abnormal_male_reproductive0.66196230
156MP0006036_abnormal_mitochondrial_physio0.66138812
157MP0003315_abnormal_perineum_morphology0.65913713
158MP0008932_abnormal_embryonic_tissue0.65800085
159MP0003077_abnormal_cell_cycle0.65697681
160MP0008469_abnormal_protein_level0.65162424
161MP0005187_abnormal_penis_morphology0.65000585
162MP0002277_abnormal_respiratory_mucosa0.64737929
163MP0005551_abnormal_eye_electrophysiolog0.63662227
164MP0000678_abnormal_parathyroid_gland0.63164671
165MP0001919_abnormal_reproductive_system0.62447652
166MP0001119_abnormal_female_reproductive0.62113378
167MP0000579_abnormal_nail_morphology0.61905722
168MP0005595_abnormal_vascular_smooth0.61182296
169MP0003959_abnormal_lean_body0.60860341

Predicted human phenotypes

RankGene SetZ-score
1Reduced antithrombin III activity (HP:0001976)8.49330306
2Type I transferrin isoform profile (HP:0003642)7.70680150
3Thyroid-stimulating hormone excess (HP:0002925)6.03463124
4Hypothermia (HP:0002045)5.32683343
5Abnormal isoelectric focusing of serum transferrin (HP:0003160)5.29590098
6Abnormal protein N-linked glycosylation (HP:0012347)5.29590098
7Abnormal protein glycosylation (HP:0012346)5.29590098
8Abnormal glycosylation (HP:0012345)5.29590098
9Abnormality of cells of the erythroid lineage (HP:0012130)4.48967741
10Abnormal number of erythroid precursors (HP:0012131)4.48774833
11Prolonged partial thromboplastin time (HP:0003645)4.42827536
12Absent rod-and cone-mediated responses on ERG (HP:0007688)4.34821675
13Volvulus (HP:0002580)3.93857262
14Nemaline bodies (HP:0003798)3.73206376
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.69906394
16Muscle fiber inclusion bodies (HP:0100299)3.66117176
17Nephroblastoma (Wilms tumor) (HP:0002667)3.57504695
18Severe visual impairment (HP:0001141)3.52513050
19Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.46862681
20Increased hepatocellular lipid droplets (HP:0006565)3.46127783
21Embryonal renal neoplasm (HP:0011794)3.44037346
22Reticulocytopenia (HP:0001896)3.37427626
23Colon cancer (HP:0003003)3.37077109
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.33324749
25Abnormality of the labia minora (HP:0012880)3.30173335
26Exercise-induced muscle cramps (HP:0003710)3.27293218
27Attenuation of retinal blood vessels (HP:0007843)3.24161430
28Abnormal hair whorl (HP:0010721)3.17723262
29Renal Fanconi syndrome (HP:0001994)3.03420965
30Abnormality of chromosome stability (HP:0003220)3.02558953
31Exertional dyspnea (HP:0002875)3.00074585
32Lipid accumulation in hepatocytes (HP:0006561)2.97843674
33Calf muscle hypertrophy (HP:0008981)2.97394198
34Muscle hypertrophy of the lower extremities (HP:0008968)2.96443652
35Subaortic stenosis (HP:0001682)2.95412657
36Abnormality of the left ventricular outflow tract (HP:0011103)2.95412657
37Biliary tract neoplasm (HP:0100574)2.95188404
38Abnormal rod and cone electroretinograms (HP:0008323)2.91403666
39Cortical visual impairment (HP:0100704)2.89305869
40Neoplasm of the adrenal cortex (HP:0100641)2.88648067
41Abnormality of secondary sexual hair (HP:0009888)2.87420201
42Abnormality of the axillary hair (HP:0100134)2.87420201
43Flat occiput (HP:0005469)2.86670162
44Gonadotropin excess (HP:0000837)2.83855577
45Rhabdomyosarcoma (HP:0002859)2.82685297
46Pancreatic islet-cell hyperplasia (HP:0004510)2.76095860
47Macrocytic anemia (HP:0001972)2.67980471
48Sex reversal (HP:0012245)2.64046251
49Abnormal sex determination (HP:0012244)2.64046251
50Papillary thyroid carcinoma (HP:0002895)2.63019743
51Nonprogressive disorder (HP:0003680)2.62913909
52Lower limb hyperreflexia (HP:0002395)2.61767295
53Aplastic anemia (HP:0001915)2.59969284
54Microcytic anemia (HP:0001935)2.54591769
55Pallor (HP:0000980)2.54269875
56Abnormality of magnesium homeostasis (HP:0004921)2.51366468
57Increased intramyocellular lipid droplets (HP:0012240)2.50681140
58Hepatocellular necrosis (HP:0001404)2.50249062
59Microvesicular hepatic steatosis (HP:0001414)2.46784669
603-Methylglutaconic aciduria (HP:0003535)2.46621535
61Abnormality of the heme biosynthetic pathway (HP:0010472)2.44893278
62Thoracic kyphosis (HP:0002942)2.37205535
63Ankle contracture (HP:0006466)2.36465923
64True hermaphroditism (HP:0010459)2.36413885
65Neoplasm of the small intestine (HP:0100833)2.36288723
66Central scotoma (HP:0000603)2.35908093
67Aplasia/Hypoplasia of the sacrum (HP:0008517)2.32124690
68Thrombocytosis (HP:0001894)2.30633612
69Ependymoma (HP:0002888)2.29768919
70T lymphocytopenia (HP:0005403)2.29392228
71Embryonal neoplasm (HP:0002898)2.27705582
72IgM deficiency (HP:0002850)2.27139906
73Birth length less than 3rd percentile (HP:0003561)2.24126979
74Abnormality of the prostate (HP:0008775)2.23538500
75Respiratory difficulties (HP:0002880)2.20326799
76Glioma (HP:0009733)2.19916669
77Abnormal spermatogenesis (HP:0008669)2.19768098
78Capillary hemangiomas (HP:0005306)2.19605760
79Abnormal lung lobation (HP:0002101)2.18069228
80Pendular nystagmus (HP:0012043)2.14387918
81Distal arthrogryposis (HP:0005684)2.12533362
82Hepatic necrosis (HP:0002605)2.11118755
83Scotoma (HP:0000575)2.10423062
84Elevated erythrocyte sedimentation rate (HP:0003565)2.10095840
85Dry hair (HP:0011359)2.10015218
86Hyperkalemia (HP:0002153)2.09760118
87Aplasia/Hypoplasia of the sternum (HP:0006714)2.08693118
88Neoplasm of striated muscle (HP:0009728)2.08629436
89Long clavicles (HP:0000890)2.07233450
90Abnormality of the columella (HP:0009929)2.07114056
91Ectopic kidney (HP:0000086)2.05724433
92Pancreatic fibrosis (HP:0100732)2.05577520
93Increased muscle lipid content (HP:0009058)2.05519432
94Areflexia of lower limbs (HP:0002522)2.05484025
95Neoplasm of the colon (HP:0100273)2.04842372
96Type 2 muscle fiber atrophy (HP:0003554)2.03737706
97Ocular albinism (HP:0001107)2.03736326
98Medulloblastoma (HP:0002885)2.02504768
99Azoospermia (HP:0000027)2.01352358
100Abnormal biliary tract morphology (HP:0012440)2.01282005
101Aplasia/Hypoplasia of the uvula (HP:0010293)2.01236817
102Difficulty running (HP:0009046)2.00191600
103Methylmalonic acidemia (HP:0002912)1.99102506
104Abnormality of the ileum (HP:0001549)1.98938055
105Decreased central vision (HP:0007663)1.98887281
106Truncal obesity (HP:0001956)1.97726227
107Chronic otitis media (HP:0000389)1.96805989
108Muscle fiber atrophy (HP:0100295)1.96302506
109Rimmed vacuoles (HP:0003805)1.95780968
110Chromosomal breakage induced by crosslinking agents (HP:0003221)1.94145916
111Neoplasm of the adrenal gland (HP:0100631)1.93977670
112Myelodysplasia (HP:0002863)1.93694244
113Split foot (HP:0001839)1.93632976
114Petechiae (HP:0000967)1.93596889
115Meningitis (HP:0001287)1.92342997
116Pancreatic cysts (HP:0001737)1.91890207
117Abnormality of T cell number (HP:0011839)1.91677215
118Astrocytoma (HP:0009592)1.90406460
119Abnormality of the astrocytes (HP:0100707)1.90406460
120Panhypogammaglobulinemia (HP:0003139)1.90322697
121Abnormality of the preputium (HP:0100587)1.90032438
122Obstructive sleep apnea (HP:0002870)1.90009929
123Homocystinuria (HP:0002156)1.89686312
124Abnormality of homocysteine metabolism (HP:0010919)1.89686312
125Abnormality of renal resorption (HP:0011038)1.88795446
126Dyschromatopsia (HP:0007641)1.87904265
127Cafe-au-lait spot (HP:0000957)1.87407494
128Hypochromic microcytic anemia (HP:0004840)1.87204100
129Congenital stationary night blindness (HP:0007642)1.86748462
130Abnormality of the fingertips (HP:0001211)1.85714927
131Abnormality of the pancreatic islet cells (HP:0006476)1.85619394
132Abnormality of endocrine pancreas physiology (HP:0012093)1.85619394
133Chromsome breakage (HP:0040012)1.84712797
134Sloping forehead (HP:0000340)1.83896831
135Curly hair (HP:0002212)1.82906525
136Pancytopenia (HP:0001876)1.81717840
137Prolonged bleeding time (HP:0003010)1.80808204
138Breast carcinoma (HP:0003002)1.80796539
139Hyporeflexia of lower limbs (HP:0002600)1.80083584
140Protruding tongue (HP:0010808)1.80041716
141Ovarian neoplasm (HP:0100615)1.79777585
142Small hand (HP:0200055)1.79621213
143Exercise-induced myalgia (HP:0003738)1.79613105
144Knee flexion contracture (HP:0006380)1.79029734
145Horizontal nystagmus (HP:0000666)1.79009447
146Thyroid carcinoma (HP:0002890)1.78189825
147Intestinal atresia (HP:0011100)1.77930021
148Cystic hygroma (HP:0000476)1.77719676
149Depressed nasal tip (HP:0000437)1.75961752
150Hepatoblastoma (HP:0002884)1.75907534
151Duplicated collecting system (HP:0000081)1.75417804
152Clitoromegaly (HP:0000057)1.75381387
153Acute lymphatic leukemia (HP:0006721)1.74937311
154Absent/shortened dynein arms (HP:0200106)1.74728459
155Dynein arm defect of respiratory motile cilia (HP:0012255)1.74728459
156Small intestinal stenosis (HP:0012848)1.74344988
157Duodenal stenosis (HP:0100867)1.74344988
158Agammaglobulinemia (HP:0004432)1.72974000
159Hypoplasia of the radius (HP:0002984)1.72224529
160Gaze-evoked nystagmus (HP:0000640)1.71688868
161Stomach cancer (HP:0012126)1.71092710
162Epistaxis (HP:0000421)1.70844503
163Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.70706319
164Decreased activity of mitochondrial respiratory chain (HP:0008972)1.70706319
165Thyroiditis (HP:0100646)1.70084342
166Myositis (HP:0100614)1.70064968
167Gastrointestinal carcinoma (HP:0002672)1.67910272
168Malignant gastrointestinal tract tumors (HP:0006749)1.67910272
169Male pseudohermaphroditism (HP:0000037)1.67389746
170Chronic obstructive pulmonary disease (HP:0006510)1.67036584
171Obstructive lung disease (HP:0006536)1.67036584
172Hyperinsulinemic hypoglycemia (HP:0000825)1.66878068
173Meckel diverticulum (HP:0002245)1.66730647
174Abnormal biliary tract physiology (HP:0012439)1.66612730
175Bile duct proliferation (HP:0001408)1.66612730
176Fair hair (HP:0002286)1.66114676
177Sensory axonal neuropathy (HP:0003390)1.65995180
178Acute myeloid leukemia (HP:0004808)1.65977512
179Abnormal pancreas size (HP:0012094)1.65723071
180Hypomagnesemia (HP:0002917)1.65521492
181Febrile seizures (HP:0002373)1.65495527
182Rectovaginal fistula (HP:0000143)1.65440659
183Rectal fistula (HP:0100590)1.65440659
184Clubbing of toes (HP:0100760)1.65178315
185Abnormality of aspartate family amino acid metabolism (HP:0010899)1.64959182
186Abnormality of the vitamin B12 metabolism (HP:0004341)1.64620893
187Impaired vibration sensation in the lower limbs (HP:0002166)1.63865482
188Intestinal fistula (HP:0100819)1.63824830
189Anencephaly (HP:0002323)1.63315550
190Iris hypopigmentation (HP:0007730)1.63112828
191Abnormality of vitamin B metabolism (HP:0004340)1.62670628
192Progressive muscle weakness (HP:0003323)1.62505255

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK9.88836644
2EIF2AK34.62442361
3NLK3.88241220
4MKNK23.46233292
5OBSCN3.41513119
6STK162.92999175
7FRK2.89182848
8MUSK2.67308885
9NUAK12.62058802
10LATS12.43092149
11MST42.22271897
12MKNK12.19958129
13NME22.18953287
14MAP3K102.18405372
15FES2.08422152
16WNK32.07309220
17WEE12.02574963
18TSSK61.96320241
19CAMKK21.91749152
20CASK1.90020053
21TLK11.87947308
22TEC1.84571232
23EIF2AK21.78440460
24TTK1.77978809
25TAF11.77725828
26KIT1.76947801
27PLK31.74866968
28IRAK31.73657199
29PASK1.67516348
30STK38L1.51849438
31CDK191.47369542
32IRAK41.46392886
33SGK21.45254370
34BRD41.44139776
35STK31.43723303
36PLK41.35686851
37VRK11.34145551
38PBK1.33203658
39FGFR21.32104110
40OXSR11.28454001
41STK241.27698031
42FGFR31.26519752
43SRPK11.26438455
44CAMK11.21156988
45PNCK1.18208333
46PIM21.17047223
47MAP2K71.16405219
48YES11.09412276
49FLT31.07875769
50STK391.05220453
51BLK1.05122914
52DYRK31.00302437
53FGFR11.00229614
54MAP3K60.98276897
55WNK10.93526296
56BTK0.92319370
57ACVR1B0.91549007
58CDK60.90345190
59STK40.89903821
60SGK30.86075543
61CAMK1G0.85141251
62ERBB30.84009632
63MATK0.81629852
64TRIM280.81360887
65AKT30.79355240
66ATM0.79115159
67ADRBK20.78985470
68PHKG10.78008310
69PHKG20.78008310
70CDK70.76998651
71MELK0.76097858
72MAPK130.75252719
73MAP3K40.74229588
74KDR0.73184304
75EEF2K0.73027230
76SGK2230.72345758
77SGK4940.72345758
78CSF1R0.72263802
79PINK10.71554443
80IRAK10.70113090
81TIE10.69504067
82MAPK40.69394364
83IRAK20.69191323
84BRSK20.68882486
85BUB10.65660143
86PKN20.65173718
87MAP3K20.65121985
88GRK10.64230453
89ALK0.60302083
90LYN0.60076142
91CLK10.58639638
92SGK10.58386678
93MAP3K70.57754815
94CDK30.57397930
95DMPK0.56668639
96MAPKAPK50.55495615
97MAP3K120.55401421
98TRPM70.53814843
99RPS6KB10.53162527
100PRKCQ0.52836009
101PLK20.51057660
102CHEK10.50484901
103TGFBR20.50195784
104MAPK150.48601471
105PRKAA20.47720780
106SYK0.46822797
107CDC70.46041786
108TAOK30.45722811
109MAPK110.45578507
110RPS6KB20.45381749
111MAP4K20.45239160
112CSNK1G10.44521617
113PRPF4B0.44122286
114IKBKB0.43654562
115ZAP700.43581407
116RIPK40.43234530
117MAP2K30.43217162
118STK110.43046118
119CDK80.42569347
120CDK40.41919990
121TXK0.41521192
122LCK0.41467759
123NEK60.41078370
124DAPK20.41055341
125PRKG20.39438953
126PRKD20.39213549
127MAP4K10.37805521
128TGFBR10.37793616
129CSK0.37250849
130PIM10.37194650
131CSNK1E0.36685852
132CSNK2A20.36586049
133ZAK0.36241783
134PRKDC0.35619566
135GRK70.35347183
136BMPR1B0.34803409
137BCKDK0.34036875
138HIPK20.33929209
139CAMK1D0.33397149
140IKBKE0.32765363
141CDK10.31477585
142EGFR0.30934865
143PRKG10.30606068
144RPS6KA40.30311723
145CSNK2A10.28383484
146CDK20.28349250
147TYK20.27526661
148ATR0.26173069
149CCNB10.25579549
150RPS6KA50.24838583
151CSNK1G30.24429683
152EIF2AK10.24373377
153MAPKAPK30.23710092
154RAF10.21846019
155MAPK120.20649758
156PIK3CG0.20298107
157CAMK40.19560018
158AURKB0.18534817
159PLK10.17365777
160SCYL20.16778312
161CHEK20.16519080
162HCK0.16253398
163MAP2K60.16089323
164INSRR0.16082369

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.80505888
2DNA replication_Homo sapiens_hsa030304.71128697
3Mismatch repair_Homo sapiens_hsa034303.05793201
4Homologous recombination_Homo sapiens_hsa034403.03110315
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.89529500
6Protein export_Homo sapiens_hsa030602.80798878
7Propanoate metabolism_Homo sapiens_hsa006402.57714077
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.55328982
9Thyroid cancer_Homo sapiens_hsa052162.55315813
10Fanconi anemia pathway_Homo sapiens_hsa034602.32522558
11Base excision repair_Homo sapiens_hsa034102.24759096
12Pyrimidine metabolism_Homo sapiens_hsa002402.19701334
13RNA polymerase_Homo sapiens_hsa030202.16988826
14N-Glycan biosynthesis_Homo sapiens_hsa005102.14350588
15Vitamin B6 metabolism_Homo sapiens_hsa007502.09469892
16Nucleotide excision repair_Homo sapiens_hsa034202.04047880
17Phototransduction_Homo sapiens_hsa047442.01834176
18Spliceosome_Homo sapiens_hsa030401.91525220
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.84739313
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.83598228
21mRNA surveillance pathway_Homo sapiens_hsa030151.78965401
22Other glycan degradation_Homo sapiens_hsa005111.72890977
23Primary immunodeficiency_Homo sapiens_hsa053401.72255242
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.67460756
25Non-homologous end-joining_Homo sapiens_hsa034501.64438009
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60222868
27Sulfur relay system_Homo sapiens_hsa041221.59163682
28Basal transcription factors_Homo sapiens_hsa030221.52479123
29One carbon pool by folate_Homo sapiens_hsa006701.45750742
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43487824
31Lysine degradation_Homo sapiens_hsa003101.40855157
32Purine metabolism_Homo sapiens_hsa002301.39926829
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33974832
34Dorso-ventral axis formation_Homo sapiens_hsa043201.33375056
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33026409
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32279481
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26087679
38Colorectal cancer_Homo sapiens_hsa052101.26016769
39Oocyte meiosis_Homo sapiens_hsa041141.25774717
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.24889633
41Systemic lupus erythematosus_Homo sapiens_hsa053221.17497102
42Folate biosynthesis_Homo sapiens_hsa007901.17252306
43Prostate cancer_Homo sapiens_hsa052151.16922946
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.15517806
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.13140678
46FoxO signaling pathway_Homo sapiens_hsa040681.11103179
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.11044011
48mTOR signaling pathway_Homo sapiens_hsa041501.10542619
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.09489277
50Long-term potentiation_Homo sapiens_hsa047201.08682266
51Selenocompound metabolism_Homo sapiens_hsa004501.06861332
52RNA degradation_Homo sapiens_hsa030181.06558396
53Proteasome_Homo sapiens_hsa030501.02957516
54Herpes simplex infection_Homo sapiens_hsa051681.02702149
55Hematopoietic cell lineage_Homo sapiens_hsa046401.02572002
56Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00851240
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00584501
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00237177
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.00129385
60p53 signaling pathway_Homo sapiens_hsa041150.99782013
61Arachidonic acid metabolism_Homo sapiens_hsa005900.97051023
62Endometrial cancer_Homo sapiens_hsa052130.95933975
63Acute myeloid leukemia_Homo sapiens_hsa052210.95735382
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94855893
65Glucagon signaling pathway_Homo sapiens_hsa049220.94630686
66Adherens junction_Homo sapiens_hsa045200.93167738
67Inositol phosphate metabolism_Homo sapiens_hsa005620.90915825
68Non-small cell lung cancer_Homo sapiens_hsa052230.89215639
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88400753
70Cell cycle_Homo sapiens_hsa041100.88182209
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87971306
72ABC transporters_Homo sapiens_hsa020100.86556317
73Taste transduction_Homo sapiens_hsa047420.84180297
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.84127609
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83924442
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82984699
77Measles_Homo sapiens_hsa051620.82348466
78T cell receptor signaling pathway_Homo sapiens_hsa046600.81760703
79Nitrogen metabolism_Homo sapiens_hsa009100.81419831
80RNA transport_Homo sapiens_hsa030130.78604325
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74169009
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.73146433
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72741805
84Asthma_Homo sapiens_hsa053100.70848277
85TGF-beta signaling pathway_Homo sapiens_hsa043500.70502138
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.69191404
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68976859
88Tight junction_Homo sapiens_hsa045300.67950818
89Oxidative phosphorylation_Homo sapiens_hsa001900.67772110
90Pentose phosphate pathway_Homo sapiens_hsa000300.67127950
91Sphingolipid metabolism_Homo sapiens_hsa006000.66978700
92MicroRNAs in cancer_Homo sapiens_hsa052060.66137563
93Renin secretion_Homo sapiens_hsa049240.65606346
94Vitamin digestion and absorption_Homo sapiens_hsa049770.65455883
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64627596
96Calcium signaling pathway_Homo sapiens_hsa040200.63950544
97Platelet activation_Homo sapiens_hsa046110.62469574
98Long-term depression_Homo sapiens_hsa047300.62086647
99Olfactory transduction_Homo sapiens_hsa047400.60436067
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.59944646
101Circadian rhythm_Homo sapiens_hsa047100.59198065
102Fatty acid elongation_Homo sapiens_hsa000620.58848779
103Melanoma_Homo sapiens_hsa052180.58363799
104Metabolic pathways_Homo sapiens_hsa011000.57432785
105Allograft rejection_Homo sapiens_hsa053300.57249908
106Oxytocin signaling pathway_Homo sapiens_hsa049210.57086248
107Insulin signaling pathway_Homo sapiens_hsa049100.56210497
108Fatty acid degradation_Homo sapiens_hsa000710.55130084
109Glioma_Homo sapiens_hsa052140.54813778
110Histidine metabolism_Homo sapiens_hsa003400.53880640
111Insulin resistance_Homo sapiens_hsa049310.53190216
112Glutathione metabolism_Homo sapiens_hsa004800.52497765
113Chronic myeloid leukemia_Homo sapiens_hsa052200.52061595
114Malaria_Homo sapiens_hsa051440.51996159
115Retinol metabolism_Homo sapiens_hsa008300.51667594
116Choline metabolism in cancer_Homo sapiens_hsa052310.51641173
117Renin-angiotensin system_Homo sapiens_hsa046140.51481313
118Pancreatic cancer_Homo sapiens_hsa052120.49999933
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.49676401
120Leishmaniasis_Homo sapiens_hsa051400.49378703
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49213100
122Regulation of autophagy_Homo sapiens_hsa041400.48249696
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48142085
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46607038
125Pyruvate metabolism_Homo sapiens_hsa006200.44336277
126Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43033119
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.40884658
128Maturity onset diabetes of the young_Homo sapiens_hsa049500.40420372
129Viral carcinogenesis_Homo sapiens_hsa052030.40342499
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.39229728
131Serotonergic synapse_Homo sapiens_hsa047260.39169074
132Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38373666
133Huntingtons disease_Homo sapiens_hsa050160.38168919
134Antigen processing and presentation_Homo sapiens_hsa046120.36334298
135Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35319405
136Linoleic acid metabolism_Homo sapiens_hsa005910.34752243
137Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34475938
138Hedgehog signaling pathway_Homo sapiens_hsa043400.33955938
139Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33823803
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33083401
141Basal cell carcinoma_Homo sapiens_hsa052170.32570898
142B cell receptor signaling pathway_Homo sapiens_hsa046620.32488300
143Prolactin signaling pathway_Homo sapiens_hsa049170.32432009
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32416982
145Salivary secretion_Homo sapiens_hsa049700.32157859
146Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31715535
147Butanoate metabolism_Homo sapiens_hsa006500.31468341
148NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31183578
149Alcoholism_Homo sapiens_hsa050340.29622003
150Wnt signaling pathway_Homo sapiens_hsa043100.29576984
151Chemical carcinogenesis_Homo sapiens_hsa052040.28033482
152Parkinsons disease_Homo sapiens_hsa050120.27920518
153Ether lipid metabolism_Homo sapiens_hsa005650.26922119
154Peroxisome_Homo sapiens_hsa041460.26406555
155Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25186309
156Autoimmune thyroid disease_Homo sapiens_hsa053200.24526753
157Arginine and proline metabolism_Homo sapiens_hsa003300.23546748
158Cysteine and methionine metabolism_Homo sapiens_hsa002700.20012782
159African trypanosomiasis_Homo sapiens_hsa051430.16666706
160Epstein-Barr virus infection_Homo sapiens_hsa051690.16320909
161Pertussis_Homo sapiens_hsa051330.13724134
162Influenza A_Homo sapiens_hsa051640.13292545

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