ZBTB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.42846537
2locomotory exploration behavior (GO:0035641)4.39590966
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.38105139
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.07677321
5vocalization behavior (GO:0071625)3.98988683
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.96752612
7synaptic vesicle exocytosis (GO:0016079)3.78142577
8cellular potassium ion homeostasis (GO:0030007)3.74098192
9regulation of synaptic vesicle exocytosis (GO:2000300)3.65323585
10glutamate secretion (GO:0014047)3.63165670
11sodium ion export (GO:0071436)3.60562623
12neuronal action potential propagation (GO:0019227)3.50799350
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.47669438
14synaptic vesicle docking involved in exocytosis (GO:0016081)3.39265326
15membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.37758840
16neurotransmitter secretion (GO:0007269)3.32942584
17regulation of glutamate receptor signaling pathway (GO:1900449)3.32918887
18cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.27998542
19regulation of synaptic vesicle transport (GO:1902803)3.25293704
20activation of protein kinase A activity (GO:0034199)3.20003098
21regulation of synapse structural plasticity (GO:0051823)3.14242365
22exploration behavior (GO:0035640)3.11166055
23potassium ion import (GO:0010107)3.06272114
24cerebellar granule cell differentiation (GO:0021707)3.06018702
25ionotropic glutamate receptor signaling pathway (GO:0035235)3.05004322
26protein localization to synapse (GO:0035418)3.04592759
27positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.04539375
28cerebellar Purkinje cell differentiation (GO:0021702)3.03024811
29layer formation in cerebral cortex (GO:0021819)3.00320387
30regulation of neuronal synaptic plasticity (GO:0048168)2.99304303
31regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.97247796
32regulation of long-term neuronal synaptic plasticity (GO:0048169)2.95680865
33positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.95012331
34cell communication by electrical coupling (GO:0010644)2.90237519
35long-term memory (GO:0007616)2.89338758
36proline transport (GO:0015824)2.88345768
37gamma-aminobutyric acid transport (GO:0015812)2.87524224
38potassium ion homeostasis (GO:0055075)2.85810074
39neuron cell-cell adhesion (GO:0007158)2.82472124
40mating behavior (GO:0007617)2.80807822
41dendritic spine morphogenesis (GO:0060997)2.78888577
42regulation of excitatory postsynaptic membrane potential (GO:0060079)2.77785566
43regulation of ARF protein signal transduction (GO:0032012)2.77163906
44membrane depolarization during action potential (GO:0086010)2.75668652
45glutamate receptor signaling pathway (GO:0007215)2.75534970
46neurotransmitter-gated ion channel clustering (GO:0072578)2.75281992
47neurotransmitter transport (GO:0006836)2.74960425
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.74296979
49negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.73439813
50protein localization to endosome (GO:0036010)2.70867558
51glycine transport (GO:0015816)2.68825939
52neuron-neuron synaptic transmission (GO:0007270)2.68005190
53synaptic transmission, glutamatergic (GO:0035249)2.67956901
54regulation of postsynaptic membrane potential (GO:0060078)2.66476367
55regulation of vesicle fusion (GO:0031338)2.63063568
56regulation of voltage-gated calcium channel activity (GO:1901385)2.61602164
57neuromuscular process controlling balance (GO:0050885)2.59406101
58positive regulation of membrane potential (GO:0045838)2.58663799
59detection of calcium ion (GO:0005513)2.57471457
60peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.57373383
61regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.57220301
62long-term synaptic potentiation (GO:0060291)2.56656652
63neuromuscular process controlling posture (GO:0050884)2.56314708
64cell communication involved in cardiac conduction (GO:0086065)2.56152418
65regulation of neurotransmitter secretion (GO:0046928)2.55276512
66positive regulation of potassium ion transmembrane transport (GO:1901381)2.54884903
67dendrite morphogenesis (GO:0048813)2.53489119
68regulation of neurotransmitter levels (GO:0001505)2.51190016
69stress fiber assembly (GO:0043149)2.51023922
70regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.50757799
71membrane depolarization (GO:0051899)2.50552354
72membrane hyperpolarization (GO:0060081)2.49150224
73regulation of extracellular matrix disassembly (GO:0010715)2.49120813
74cellular sodium ion homeostasis (GO:0006883)2.48752060
75regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.48562773
76cytoskeletal anchoring at plasma membrane (GO:0007016)2.48310109
77negative regulation of erythrocyte differentiation (GO:0045647)2.48304936
78cell-substrate junction assembly (GO:0007044)2.47703492
79regulation of synaptic plasticity (GO:0048167)2.47692562
80vesicle transport along microtubule (GO:0047496)2.47326281
81protein targeting to plasma membrane (GO:0072661)2.46930491
82gamma-aminobutyric acid signaling pathway (GO:0007214)2.46478096
83transmission of nerve impulse (GO:0019226)2.44851493
84positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.43995079
85regulation of synaptic transmission, glutamatergic (GO:0051966)2.43287622
86negative regulation of cytosolic calcium ion concentration (GO:0051481)2.43084087
87positive regulation of potassium ion transport (GO:0043268)2.42807338
88barbed-end actin filament capping (GO:0051016)2.42499814
89positive regulation of vesicle fusion (GO:0031340)2.41994343
90positive regulation of receptor recycling (GO:0001921)2.41531772
91extracellular matrix assembly (GO:0085029)2.41307144
92membrane repolarization (GO:0086009)2.41304103
93negative regulation of synaptic transmission, GABAergic (GO:0032229)2.38716487
94regulation of dendritic spine morphogenesis (GO:0061001)2.38130064
95endothelial cell chemotaxis (GO:0035767)2.37792934
96auditory behavior (GO:0031223)2.37708292
97regulation of neurotransmitter transport (GO:0051588)2.37615603
98adherens junction assembly (GO:0034333)2.37456151
99positive regulation of fibroblast migration (GO:0010763)2.37432305
100peptidyl-tyrosine autophosphorylation (GO:0038083)2.36902149
101synaptic vesicle endocytosis (GO:0048488)2.36729032
102neuronal ion channel clustering (GO:0045161)2.36656469
103cellular response to monoamine stimulus (GO:0071868)2.36500518
104cellular response to catecholamine stimulus (GO:0071870)2.36500518
105response to auditory stimulus (GO:0010996)2.36018472
106positive regulation of Rap GTPase activity (GO:0032854)2.35704218
107neuron recognition (GO:0008038)2.35277544
108positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.34489943
109regulation of calcium ion transmembrane transporter activity (GO:1901019)2.33868662
110regulation of calcium ion transmembrane transport (GO:1903169)2.33868662
111positive regulation of synaptic transmission, GABAergic (GO:0032230)2.33486835
112innervation (GO:0060384)2.32981144
113prepulse inhibition (GO:0060134)2.32939189
114regulation of clathrin-mediated endocytosis (GO:2000369)2.32703119
115L-amino acid import (GO:0043092)2.32532594
116cellular response to epinephrine stimulus (GO:0071872)2.32247765
117G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.32058931
118negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.31754035
119focal adhesion assembly (GO:0048041)2.31047647
120cell-substrate adherens junction assembly (GO:0007045)2.31047647
121suckling behavior (GO:0001967)2.28555124
122positive regulation of synaptic transmission (GO:0050806)2.28103288
123regulation of membrane repolarization (GO:0060306)2.27866426
124regulation of early endosome to late endosome transport (GO:2000641)2.25273571
125cortical actin cytoskeleton organization (GO:0030866)2.25243078
126regulation of T-helper 2 cell differentiation (GO:0045628)2.23848201
127positive regulation of synapse maturation (GO:0090129)2.23747008
128skin morphogenesis (GO:0043589)2.22050781
129cAMP biosynthetic process (GO:0006171)2.16646137
130cell volume homeostasis (GO:0006884)2.12649031
131negative regulation of fatty acid transport (GO:2000192)2.12527022
132signal complex assembly (GO:0007172)2.11201294
133protein heterotrimerization (GO:0070208)2.09039187
134hemidesmosome assembly (GO:0031581)2.08889102
135cortical cytoskeleton organization (GO:0030865)2.08837270
136positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.08546830
137insulin-like growth factor receptor signaling pathway (GO:0048009)2.08159540
138vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.07391762
139regulation of Rap GTPase activity (GO:0032317)2.06977075
140positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.06722903
141positive regulation of protein dephosphorylation (GO:0035307)2.05946206
142hypotonic response (GO:0006971)2.04890692
143amino acid import (GO:0043090)2.04772773
144response to laminar fluid shear stress (GO:0034616)2.04491005
145cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.03626546
146surfactant homeostasis (GO:0043129)2.03268438
147response to fluid shear stress (GO:0034405)2.02364643
148response to catecholamine (GO:0071869)2.01898245
149response to monoamine (GO:0071867)2.01898245
150extracellular fibril organization (GO:0043206)2.00875743
151vascular endothelial growth factor signaling pathway (GO:0038084)2.00610112
152semaphorin-plexin signaling pathway (GO:0071526)1.99758051
153endocytic recycling (GO:0032456)1.98902292
154fibril organization (GO:0097435)1.97471381
155positive regulation of extracellular matrix organization (GO:1903055)1.92367774
156negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)1.91970903
157dopamine receptor signaling pathway (GO:0007212)1.91643108
158myelin maintenance (GO:0043217)1.91451574
159positive regulation of blood vessel endothelial cell migration (GO:0043536)1.90431795
160positive regulation of axon extension (GO:0045773)1.90110982
161regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)1.89273513
162neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)1.88805458
163regulation of ARF GTPase activity (GO:0032312)1.88553832
164venous blood vessel morphogenesis (GO:0048845)1.86912848
165cell migration involved in heart development (GO:0060973)1.86075644
166mannose metabolic process (GO:0006013)1.85789846
167negative regulation of Ras protein signal transduction (GO:0046580)1.85468106

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.84719439
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.74735373
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.64971002
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.52175627
5GBX2_23144817_ChIP-Seq_PC3_Human2.48058861
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44153483
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44153483
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42392900
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.41129491
10DROSHA_22980978_ChIP-Seq_HELA_Human2.35437696
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32034370
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27855939
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26892899
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24849509
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20688723
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15154973
17EZH2_27304074_Chip-Seq_ESCs_Mouse1.96201063
18SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93409006
19EZH2_27294783_Chip-Seq_ESCs_Mouse1.92234120
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.91620058
21* RARB_27405468_Chip-Seq_BRAIN_Mouse1.91585200
22LXR_22292898_ChIP-Seq_THP-1_Human1.89954543
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88663808
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.86786791
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.86577539
26AR_21572438_ChIP-Seq_LNCaP_Human1.78512439
27REST_21632747_ChIP-Seq_MESCs_Mouse1.75185864
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.73564655
29KDM2B_26808549_Chip-Seq_DND41_Human1.65522050
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.57170603
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52458583
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51793285
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49473832
34TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49250638
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.48060437
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.47088465
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.45569270
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45495872
39SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.44854542
40TCF7_22412390_ChIP-Seq_EML_Mouse1.44626621
41RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42072502
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.41774401
43RACK7_27058665_Chip-Seq_MCF-7_Human1.41665352
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41552655
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41148617
46* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39753911
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39094568
48KDM2B_26808549_Chip-Seq_JURKAT_Human1.38261178
49SMAD4_21799915_ChIP-Seq_A2780_Human1.37100087
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34844746
51* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34208479
52AHR_22903824_ChIP-Seq_MCF-7_Human1.33082249
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.30135029
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.30116824
55* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29982418
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29476909
57EP300_21415370_ChIP-Seq_HL-1_Mouse1.28283774
58TBX20_22328084_ChIP-Seq_HEART_Mouse1.26964615
59TBX20_22080862_ChIP-Seq_HEART_Mouse1.26964615
60KDM2B_26808549_Chip-Seq_K562_Human1.26874023
61SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26695717
62CLOCK_20551151_ChIP-Seq_293T_Human1.25268419
63NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23607211
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.23541979
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.22481716
66TAF15_26573619_Chip-Seq_HEK293_Human1.20285193
67TRIM28_21343339_ChIP-Seq_HEK293_Human1.15508457
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15499678
69UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14814555
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14679627
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.14602217
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14470695
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13596956
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.13179152
75P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13127856
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.12990800
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12661450
78* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12007499
79TET1_21490601_ChIP-Seq_MESCs_Mouse1.11491132
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11183158
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11044254
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10877902
83CTCF_27219007_Chip-Seq_Bcells_Human1.10567429
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10182176
85DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09705564
86AR_19668381_ChIP-Seq_PC3_Human1.07311906
87STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.07275682
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05204614
89THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04837066
90SMC4_20622854_ChIP-Seq_HELA_Human1.04322695
91NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04056158
92GATA1_19941826_ChIP-Seq_K562_Human1.03943347
93CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03123167
94ESR1_20079471_ChIP-ChIP_T-47D_Human1.03091688
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02836237
96SMAD3_21741376_ChIP-Seq_HESCs_Human1.02530737
97AR_25329375_ChIP-Seq_VCAP_Human1.02506479
98BCAT_22108803_ChIP-Seq_LS180_Human1.02262110
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.01375579
100TP53_16413492_ChIP-PET_HCT116_Human1.01177213
101STAT3_23295773_ChIP-Seq_U87_Human1.01029435
102SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00526286
103TP53_23651856_ChIP-Seq_MEFs_Mouse1.00163941
104SMAD4_21741376_ChIP-Seq_HESCs_Human0.99976699
105SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99633413
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99345037
107CREB1_26743006_Chip-Seq_LNCaP_Human0.98875275
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98237233
109ZNF274_21170338_ChIP-Seq_K562_Hela0.97032565
110* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96719554
111P300_19829295_ChIP-Seq_ESCs_Human0.96684745
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96610612
113TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96529342
114EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96054429
115RUNX1_27514584_Chip-Seq_MCF-7_Human0.95972018
116RXR_22108803_ChIP-Seq_LS180_Human0.95322502
117OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95129779
118NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94978366
119CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94653085
120* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94586161
121GATA1_19941827_ChIP-Seq_MEL_Mouse0.94238776
122RING1B_27294783_Chip-Seq_NPCs_Mouse0.94120043
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93915443
124GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92049261
125TP53_20018659_ChIP-ChIP_R1E_Mouse0.91325406
126KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91305111
127TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91287472
128TP53_18474530_ChIP-ChIP_U2OS_Human0.90554155
129FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.90354314
130NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89968355
131CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89218194
132NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88080459
133NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88080459
134SA1_27219007_Chip-Seq_ERYTHROID_Human0.87747250
135* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87555057
136NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87377863
137SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87256127
138YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87118665
139PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86815582
140CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86212208
141* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.86171354
142MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85780472
143* TCF4_23295773_ChIP-Seq_U87_Human0.85754330
144GATA2_21666600_ChIP-Seq_HMVEC_Human0.84780589
145* TP63_22573176_ChIP-Seq_HFKS_Human0.84411333
146TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84131255
147SMAD3_21741376_ChIP-Seq_ESCs_Human0.83480254
148GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82755720
149TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82422595
150ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81682667
151ZFP57_27257070_Chip-Seq_ESCs_Mouse0.81486376

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.17282418
2MP0003705_abnormal_hypodermis_morpholog3.84514467
3MP0008438_abnormal_cutaneous_collagen3.63166837
4MP0003635_abnormal_synaptic_transmissio3.38688648
5MP0004270_analgesia3.35854436
6MP0003880_abnormal_central_pattern3.29823978
7MP0003279_aneurysm2.84359651
8MP0005275_abnormal_skin_tensile2.79841172
9MP0009745_abnormal_behavioral_response2.72302021
10MP0009046_muscle_twitch2.66840306
11MP0002064_seizures2.65931330
12MP0002822_catalepsy2.61993500
13MP0005503_abnormal_tendon_morphology2.59169309
14MP0002063_abnormal_learning/memory/cond2.44639509
15MP0009780_abnormal_chondrocyte_physiolo2.38580250
16MP0002909_abnormal_adrenal_gland2.33671917
17MP0001968_abnormal_touch/_nociception2.30852363
18MP0002272_abnormal_nervous_system2.27239875
19MP0001501_abnormal_sleep_pattern2.25037623
20MP0002572_abnormal_emotion/affect_behav2.14348839
21MP0002734_abnormal_mechanical_nocicepti2.13524440
22MP0003566_abnormal_cell_adhesion2.08471737
23MP0001486_abnormal_startle_reflex2.05416344
24MP0005423_abnormal_somatic_nervous1.98136659
25MP0008569_lethality_at_weaning1.97726356
26MP0000751_myopathy1.95652886
27MP0002837_dystrophic_cardiac_calcinosis1.94172844
28MP0003091_abnormal_cell_migration1.89043511
29MP0000013_abnormal_adipose_tissue1.83961535
30MP0001348_abnormal_lacrimal_gland1.75970829
31MP0001440_abnormal_grooming_behavior1.67915937
32MP0003329_amyloid_beta_deposits1.67482867
33MP0001970_abnormal_pain_threshold1.66422437
34MP0002735_abnormal_chemical_nociception1.66389804
35MP0002067_abnormal_sensory_capabilities1.66175753
36MP0002733_abnormal_thermal_nociception1.64163852
37MP0004858_abnormal_nervous_system1.63787750
38MP0002736_abnormal_nociception_after1.62134395
39MP0004272_abnormal_basement_membrane1.55658217
40MP0005551_abnormal_eye_electrophysiolog1.46453525
41MP0010368_abnormal_lymphatic_system1.45861006
42MP0000767_abnormal_smooth_muscle1.44890383
43MP0004130_abnormal_muscle_cell1.42839323
44MP0003633_abnormal_nervous_system1.41745477
45MP0003045_fibrosis1.40770391
46MP0001849_ear_inflammation1.40046533
47MP0008961_abnormal_basal_metabolism1.37953370
48MP0004885_abnormal_endolymph1.37697626
49MP0002184_abnormal_innervation1.35908045
50MP0004924_abnormal_behavior1.35635670
51MP0005386_behavior/neurological_phenoty1.35635670
52MP0003300_gastrointestinal_ulcer1.35595712
53MP0003191_abnormal_cellular_cholesterol1.35576482
54MP0005023_abnormal_wound_healing1.33412183
55MP0002090_abnormal_vision1.30611246
56MP0004145_abnormal_muscle_electrophysio1.30296655
57MP0002557_abnormal_social/conspecific_i1.28830413
58MP0004036_abnormal_muscle_relaxation1.26934747
59MP0005257_abnormal_intraocular_pressure1.26340249
60MP0010386_abnormal_urinary_bladder1.25667359
61MP0003690_abnormal_glial_cell1.24103533
62MP0004811_abnormal_neuron_physiology1.21722112
63MP0004215_abnormal_myocardial_fiber1.19023111
64MP0005058_abnormal_lysosome_morphology1.18145419
65MP0002896_abnormal_bone_mineralization1.17870460
66MP0009384_cardiac_valve_regurgitation1.17847344
67MP0001502_abnormal_circadian_rhythm1.16999157
68MP0002998_abnormal_bone_remodeling1.16978746
69MP0010234_abnormal_vibrissa_follicle1.16304511
70MP0004085_abnormal_heartbeat1.16030973
71MP0002295_abnormal_pulmonary_circulatio1.15987672
72MP0003879_abnormal_hair_cell1.15366604
73MP0000955_abnormal_spinal_cord1.15012881
74MP0005623_abnormal_meninges_morphology1.13875893
75MP0002882_abnormal_neuron_morphology1.13777385
76MP0002066_abnormal_motor_capabilities/c1.12945472
77MP0005167_abnormal_blood-brain_barrier1.11514145
78MP0003828_pulmonary_edema1.10390415
79MP0000920_abnormal_myelination1.08566798
80MP0001984_abnormal_olfaction1.08072391
81MP0004484_altered_response_of1.07348841
82MP0000778_abnormal_nervous_system1.07119041
83MP0002108_abnormal_muscle_morphology1.07051328
84MP0003631_nervous_system_phenotype1.06173398
85MP0005388_respiratory_system_phenotype1.05846784
86MP0002133_abnormal_respiratory_system1.05846784
87MP0002229_neurodegeneration1.05493165
88MP0001542_abnormal_bone_strength1.04772835
89MP0005670_abnormal_white_adipose1.04327490
90MP0002933_joint_inflammation1.04322176
91MP0004084_abnormal_cardiac_muscle1.04096521
92MP0008874_decreased_physiological_sensi1.02710157
93MP0002060_abnormal_skin_morphology1.02254498
94MP0005508_abnormal_skeleton_morphology1.01154254
95MP0004510_myositis1.00620826
96MP0003634_abnormal_glial_cell1.00170155
97MP0001177_atelectasis0.98360812
98MP0005535_abnormal_body_temperature0.98077131
99MP0005666_abnormal_adipose_tissue0.97811921
100MP0000003_abnormal_adipose_tissue0.97411224
101MP0006276_abnormal_autonomic_nervous0.96824217
102MP0006072_abnormal_retinal_apoptosis0.93155463
103MP0005646_abnormal_pituitary_gland0.91562202
104MP0003075_altered_response_to0.91516555
105MP0000759_abnormal_skeletal_muscle0.90385190
106MP0005620_abnormal_muscle_contractility0.89842932
107MP0003283_abnormal_digestive_organ0.89526559
108MP0003453_abnormal_keratinocyte_physiol0.89510579
109MP0000733_abnormal_muscle_development0.87898184
110MP0001851_eye_inflammation0.86504974
111MP0002249_abnormal_larynx_morphology0.86504363
112MP0001958_emphysema0.85636220
113MP0000747_muscle_weakness0.84308199
114MP0001299_abnormal_eye_distance/0.83398608
115MP0005390_skeleton_phenotype0.82882947
116MP0002877_abnormal_melanocyte_morpholog0.82631574
117MP0001533_abnormal_skeleton_physiology0.80629263
118MP0001879_abnormal_lymphatic_vessel0.78925256
119MP0004947_skin_inflammation0.78753355
120MP0004043_abnormal_pH_regulation0.78307782
121MP0005375_adipose_tissue_phenotype0.78160845
122MP0000678_abnormal_parathyroid_gland0.77579020
123MP0000534_abnormal_ureter_morphology0.77551563
124MP0002972_abnormal_cardiac_muscle0.77222174
125MP0000604_amyloidosis0.77027324
126MP0000681_abnormal_thyroid_gland0.75864030
127MP0001905_abnormal_dopamine_level0.75802487
128MP0005164_abnormal_response_to0.75475087
129MP0003183_abnormal_peptide_metabolism0.74471444
130MP0003137_abnormal_impulse_conducting0.74449828
131MP0005165_increased_susceptibility_to0.74422726
132MP0005645_abnormal_hypothalamus_physiol0.74361302
133MP0002971_abnormal_brown_adipose0.73956930
134MP0004742_abnormal_vestibular_system0.73731428
135MP0005409_darkened_coat_color0.73711083
136MP0002069_abnormal_eating/drinking_beha0.73114899
137MP0008872_abnormal_physiological_respon0.72517441
138MP0003436_decreased_susceptibility_to0.72016442
139MP0003303_peritoneal_inflammation0.71844307
140MP0004883_abnormal_blood_vessel0.71622240
141MP0009840_abnormal_foam_cell0.71494377
142MP0006138_congestive_heart_failure0.70097157
143MP0000749_muscle_degeneration0.69170906
144MP0000230_abnormal_systemic_arterial0.68961922
145MP0004185_abnormal_adipocyte_glucose0.68145966
146MP0001765_abnormal_ion_homeostasis0.67970787
147MP0005595_abnormal_vascular_smooth0.67307924
148MP0004142_abnormal_muscle_tone0.67288535
149MP0003632_abnormal_nervous_system0.67057269
150MP0003172_abnormal_lysosome_physiology0.66976174
151MP0002152_abnormal_brain_morphology0.66756636
152MP0004087_abnormal_muscle_fiber0.66011627

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.60630270
2Myokymia (HP:0002411)4.80101370
3Focal seizures (HP:0007359)4.39316855
4Protrusio acetabuli (HP:0003179)4.30900698
5Visual hallucinations (HP:0002367)4.06442715
6Action tremor (HP:0002345)3.96524970
7Atonic seizures (HP:0010819)3.72206470
8Aortic aneurysm (HP:0004942)3.56157464
9Progressive cerebellar ataxia (HP:0002073)3.45000112
10Supranuclear gaze palsy (HP:0000605)3.41213378
11Febrile seizures (HP:0002373)3.31314306
12Premature rupture of membranes (HP:0001788)3.24635387
13Absence seizures (HP:0002121)3.24351654
14Epileptic encephalopathy (HP:0200134)3.23728359
15Aortic dissection (HP:0002647)2.96927434
16Generalized tonic-clonic seizures (HP:0002069)2.91534997
17Dialeptic seizures (HP:0011146)2.90901473
18Dysdiadochokinesis (HP:0002075)2.88609408
19Ankle clonus (HP:0011448)2.86163556
20Shallow orbits (HP:0000586)2.84244101
21Dysmetria (HP:0001310)2.79230230
22Ventricular fibrillation (HP:0001663)2.74875021
23Hemiplegia (HP:0002301)2.73849954
24Depression (HP:0000716)2.73495867
25Type 1 muscle fiber predominance (HP:0003803)2.69942127
26Neurofibrillary tangles (HP:0002185)2.64283848
27Atrophic scars (HP:0001075)2.64206336
28Postural instability (HP:0002172)2.63301221
29Broad-based gait (HP:0002136)2.62767319
30Truncal ataxia (HP:0002078)2.62287956
31Anxiety (HP:0000739)2.61232502
32Intention tremor (HP:0002080)2.58418805
33Gaze-evoked nystagmus (HP:0000640)2.49406211
34Dysmetric saccades (HP:0000641)2.48633386
35Increased connective tissue (HP:0009025)2.45381732
36Prolonged QT interval (HP:0001657)2.44877855
37Cerebral inclusion bodies (HP:0100314)2.42844545
38Spinal rigidity (HP:0003306)2.41148835
39Broad metatarsal (HP:0001783)2.39906554
40Abnormality of skeletal muscle fiber size (HP:0012084)2.39355071
41Sudden death (HP:0001699)2.38968661
42Genetic anticipation (HP:0003743)2.38260549
43Scanning speech (HP:0002168)2.38251380
44Distal lower limb muscle weakness (HP:0009053)2.38068427
45Impaired social interactions (HP:0000735)2.36156360
46Abnormal social behavior (HP:0012433)2.36156360
47Central scotoma (HP:0000603)2.34999423
48Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.33406281
49Aneurysm (HP:0002617)2.33020922
50Fragile skin (HP:0001030)2.32547931
51Rapidly progressive (HP:0003678)2.32063717
52Wormian bones (HP:0002645)2.31348393
53Asymmetric septal hypertrophy (HP:0001670)2.30803811
54Vertebral compression fractures (HP:0002953)2.30660084
55Dilatation of the ascending aorta (HP:0005111)2.30353537
56Bladder diverticulum (HP:0000015)2.29862410
57Abnormal eating behavior (HP:0100738)2.29667503
58Urinary bladder sphincter dysfunction (HP:0002839)2.28996978
59Exercise-induced myalgia (HP:0003738)2.28804404
60Mitral regurgitation (HP:0001653)2.28430933
61Poor eye contact (HP:0000817)2.27683536
62Bundle branch block (HP:0011710)2.27456763
63Papilledema (HP:0001085)2.26395858
64Hyporeflexia of lower limbs (HP:0002600)2.24104447
65Syncope (HP:0001279)2.23166890
66Broad face (HP:0000283)2.20023722
67Progressive inability to walk (HP:0002505)2.19889002
68Cervical subluxation (HP:0003308)2.16173131
69Agitation (HP:0000713)2.15268893
70Impaired vibration sensation in the lower limbs (HP:0002166)2.13358390
71Megalencephaly (HP:0001355)2.12299587
72Urinary urgency (HP:0000012)2.11666734
73Mutism (HP:0002300)2.10230976
74Mildly elevated creatine phosphokinase (HP:0008180)2.09648227
75Increased variability in muscle fiber diameter (HP:0003557)2.09005274
76Torticollis (HP:0000473)2.07753601
77Amblyopia (HP:0000646)2.07577361
78Myotonia (HP:0002486)2.06720819
79Pheochromocytoma (HP:0002666)2.06501229
80Hyperventilation (HP:0002883)2.06256485
81Muscle fiber splitting (HP:0003555)2.06178823
82Spastic gait (HP:0002064)2.05940276
83Excessive salivation (HP:0003781)2.05348478
84Drooling (HP:0002307)2.05348478
85Aplasia involving bones of the extremities (HP:0009825)2.05251947
86Aplasia involving bones of the upper limbs (HP:0009823)2.05251947
87Aplasia of the phalanges of the hand (HP:0009802)2.05251947
88Termporal pattern (HP:0011008)2.05047476
89Insidious onset (HP:0003587)2.05047476
90Mitral valve prolapse (HP:0001634)2.05034298
91Diplopia (HP:0000651)2.04861346
92Abnormality of binocular vision (HP:0011514)2.04861346
93Abnormal EKG (HP:0003115)2.04626723
94Ankle contracture (HP:0006466)2.04247410
95Distal lower limb amyotrophy (HP:0008944)2.03919052
96Hypercortisolism (HP:0001578)2.02830918
97Lower limb muscle weakness (HP:0007340)2.02281324
98Hemiparesis (HP:0001269)2.00025732
99Postural tremor (HP:0002174)1.98867212
100Cerebral aneurysm (HP:0004944)1.98800120
101Arterial tortuosity (HP:0005116)1.96610739
102Difficulty running (HP:0009046)1.95423716
103Hypoventilation (HP:0002791)1.94998510
104Hyperacusis (HP:0010780)1.94459400
105Lower limb amyotrophy (HP:0007210)1.94177061
106Impaired smooth pursuit (HP:0007772)1.93186493
107Congenital stationary night blindness (HP:0007642)1.91815777
108Genu recurvatum (HP:0002816)1.91054105
109Neonatal short-limb short stature (HP:0008921)1.87317679
110Atrial fibrillation (HP:0005110)1.87110755
111Slender build (HP:0001533)1.86977777
112Mild short stature (HP:0003502)1.86483135
113Aortic regurgitation (HP:0001659)1.86189657
114Dysostosis multiplex (HP:0000943)1.85031993
115Interstitial pulmonary disease (HP:0006530)1.83706144
116Stereotypic behavior (HP:0000733)1.83684019
117Hypoplasia of the iris (HP:0007676)1.82992566
118Round ear (HP:0100830)1.82860038
119Lower limb asymmetry (HP:0100559)1.82822050
120Neuronal loss in central nervous system (HP:0002529)1.82707149
121Onion bulb formation (HP:0003383)1.82590823
122Vascular tortuosity (HP:0004948)1.81950222
123Upper limb amyotrophy (HP:0009129)1.81532767
124Distal upper limb amyotrophy (HP:0007149)1.81532767
125Primary atrial arrhythmia (HP:0001692)1.80811485
126Exotropia (HP:0000577)1.80305373
127Osteolytic defects of the phalanges of the hand (HP:0009771)1.80253850
128Osteolytic defects of the hand bones (HP:0009699)1.80253850
129Bronchomalacia (HP:0002780)1.80216739
130Spondylolisthesis (HP:0003302)1.79231779
131Hyperextensible skin (HP:0000974)1.78669523
132Overgrowth (HP:0001548)1.78532498
133Urinary glycosaminoglycan excretion (HP:0003541)1.77806583
134Mucopolysacchariduria (HP:0008155)1.77806583
135Hammertoe (HP:0001765)1.77393360
136Turricephaly (HP:0000262)1.77207625
137Bradykinesia (HP:0002067)1.76986070
138Resting tremor (HP:0002322)1.76524249
139Joint laxity (HP:0001388)1.76225946
140Axonal loss (HP:0003447)1.75268144
141Annular pancreas (HP:0001734)1.74525247
142Obstructive sleep apnea (HP:0002870)1.74307614
143Bradycardia (HP:0001662)1.72701493
144Emphysema (HP:0002097)1.72515273
145Mitral stenosis (HP:0001718)1.72514611
146Focal dystonia (HP:0004373)1.71798053
147Macroorchidism (HP:0000053)1.71699447
148Blue sclerae (HP:0000592)1.71470366
149Peritonitis (HP:0002586)1.70417344
150Striae distensae (HP:0001065)1.69532974
151Psychosis (HP:0000709)1.68271223
152Abnormal atrioventricular conduction (HP:0005150)1.67301044
153Abnormality of polysaccharide metabolism (HP:0011012)1.67027930
154Abnormality of glycosaminoglycan metabolism (HP:0004371)1.67027930
155Abnormality of mucopolysaccharide metabolism (HP:0011020)1.67027930
156Soft skin (HP:0000977)1.66385733
157Joint stiffness (HP:0001387)1.65705344
158Sleep apnea (HP:0010535)1.65074623
159Nuclear cataract (HP:0100018)1.63970953
160Hyperparathyroidism (HP:0000843)1.63571129
161Spinal canal stenosis (HP:0003416)1.63025611
162Follicular hyperkeratosis (HP:0007502)1.61453509
163Neoplasm of the heart (HP:0100544)1.60858651
164Short nail (HP:0001799)1.59517717
165Vertebral arch anomaly (HP:0008438)1.58655678
166Ulnar bowing (HP:0003031)1.56373114
167Thin bony cortex (HP:0002753)1.55743823

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.32888267
2MAP3K92.98044598
3EPHA42.80348909
4NTRK12.21508418
5DAPK21.99248629
6MAP3K21.97789909
7PRKD31.97704969
8LMTK21.93984206
9ERN11.90551254
10MAP3K41.90303773
11MINK11.86613650
12KSR21.82134607
13PAK61.80236941
14RIPK11.77934877
15CAMKK11.57512252
16PHKG11.53604744
17PHKG21.53604744
18NTRK21.50014367
19PRKCH1.49474966
20MAP2K41.47687766
21CAMK1G1.41385052
22GRK51.39464448
23RIPK41.34348058
24STK381.33024113
25WNK11.31967913
26DMPK1.30740853
27MARK11.29803985
28CDK51.28834099
29LATS21.28366023
30MAP3K121.26517245
31SIK21.25780298
32ICK1.24021889
33MAP2K71.22134458
34TGFBR21.21815898
35CAMKK21.19120341
36MAP3K131.12999144
37RET1.12304187
38FES1.12085944
39TRIB31.12065736
40FGFR41.11612763
41PTK21.10583828
42FER1.07136993
43MAP3K11.05678438
44PAK31.05261077
45TESK11.04896036
46MAPK71.03772495
47SGK4941.03257903
48SGK2231.03257903
49MAP3K71.01445678
50SGK30.98992213
51STK110.97411234
52CAMK10.96154911
53EEF2K0.94867515
54FGFR20.94484196
55SMG10.94448154
56MARK20.94179615
57PTK2B0.93051032
58CASK0.92057585
59PDPK10.89813779
60PRPF4B0.89735087
61SGK20.89640325
62OXSR10.87964061
63PDGFRA0.87789799
64CAMK2A0.85833159
65TAOK10.85465650
66CAMK2B0.84891010
67CAMK2D0.84575066
68MAP3K30.84249078
69ZAP700.84030472
70STK390.82642795
71WNK40.82612017
72PINK10.82601126
73INSRR0.81405179
74CDK120.81076898
75PRKD10.80781542
76UHMK10.79713529
77MOS0.79331526
78CDC42BPA0.79272155
79PNCK0.79100021
80CAMK1D0.78684258
81TYRO30.78552419
82PDK10.77934443
83ARAF0.76695210
84TNIK0.76545185
85PRKD20.76306964
86PRKCG0.73706263
87FGFR30.72794661
88TRPM70.72746522
89MAPK150.72684662
90PKN20.72643348
91MTOR0.71252779
92PRKCE0.70197225
93EPHB20.70166504
94AKT30.70082228
95PAK20.67642861
96MYLK0.67416651
97PLK20.67055559
98SGK10.66959329
99TNK20.66699208
100TTN0.66548111
101CAMK2G0.65872005
102MAPK120.62829816
103MAP2K10.62732899
104EPHB10.62221797
105BLK0.62166242
106TYK20.61941944
107TIE10.61310698
108ROCK20.61124090
109KSR10.59135485
110EPHA20.58862351
111SIK10.58268528
112ROCK10.57364092
113PTK60.56985308
114JAK10.56333685
115CDK190.56020072
116FYN0.55602232
117MAP2K30.54423449
118MAP4K10.54248953
119NEK60.53909178
120MAP3K60.52413334
121MAPK40.52384638
122CAMK40.52106531
123DAPK10.51719424
124DDR20.51571192
125MAP3K110.50169456
126RPS6KA30.49212359
127RPS6KL10.48590232
128RPS6KC10.48590232
129MAPK100.48551411
130ALK0.48427744
131CSNK1G20.47975606
132RPS6KA20.47964754
133PDGFRB0.47172008
134CSK0.46214725
135MAPK130.45618290
136PRKG20.45215280

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.39210013
2Nicotine addiction_Homo sapiens_hsa050332.30027409
3Circadian entrainment_Homo sapiens_hsa047132.12099372
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.07335201
5GABAergic synapse_Homo sapiens_hsa047272.07236236
6Olfactory transduction_Homo sapiens_hsa047402.04633853
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.02409457
8Long-term potentiation_Homo sapiens_hsa047201.99931041
9Glutamatergic synapse_Homo sapiens_hsa047241.96675986
10Salivary secretion_Homo sapiens_hsa049701.96376942
11Morphine addiction_Homo sapiens_hsa050321.90417673
12Insulin secretion_Homo sapiens_hsa049111.88627243
13Gastric acid secretion_Homo sapiens_hsa049711.87099525
14Amphetamine addiction_Homo sapiens_hsa050311.79583360
15Renin secretion_Homo sapiens_hsa049241.77734311
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75227744
17Cholinergic synapse_Homo sapiens_hsa047251.67969755
18Dopaminergic synapse_Homo sapiens_hsa047281.67787330
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58159548
20Phototransduction_Homo sapiens_hsa047441.52067871
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51881407
22Oxytocin signaling pathway_Homo sapiens_hsa049211.46858876
23Taste transduction_Homo sapiens_hsa047421.45261965
24Long-term depression_Homo sapiens_hsa047301.41553107
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39645639
26Cocaine addiction_Homo sapiens_hsa050301.38125850
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.37452092
28Calcium signaling pathway_Homo sapiens_hsa040201.34439457
29GnRH signaling pathway_Homo sapiens_hsa049121.32436602
30Serotonergic synapse_Homo sapiens_hsa047261.28016546
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.25454720
32Type II diabetes mellitus_Homo sapiens_hsa049301.22326692
33Nitrogen metabolism_Homo sapiens_hsa009101.22014645
34Dilated cardiomyopathy_Homo sapiens_hsa054141.21546378
35cAMP signaling pathway_Homo sapiens_hsa040241.21257133
36cGMP-PKG signaling pathway_Homo sapiens_hsa040221.20056682
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18823658
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16097094
39Vascular smooth muscle contraction_Homo sapiens_hsa042701.13687552
40Estrogen signaling pathway_Homo sapiens_hsa049151.12898462
41Gap junction_Homo sapiens_hsa045401.11645111
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11453611
43Pancreatic secretion_Homo sapiens_hsa049721.08215048
44Notch signaling pathway_Homo sapiens_hsa043301.08052425
45Collecting duct acid secretion_Homo sapiens_hsa049661.05674359
46Dorso-ventral axis formation_Homo sapiens_hsa043200.96924381
47Melanogenesis_Homo sapiens_hsa049160.93962839
48Thyroid hormone synthesis_Homo sapiens_hsa049180.91828483
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.91710547
50Cardiac muscle contraction_Homo sapiens_hsa042600.91520250
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91517035
52Chronic myeloid leukemia_Homo sapiens_hsa052200.91325430
53Glioma_Homo sapiens_hsa052140.90885380
54Glycosaminoglycan degradation_Homo sapiens_hsa005310.90143408
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89834799
56Non-small cell lung cancer_Homo sapiens_hsa052230.89571349
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.89077489
58Acute myeloid leukemia_Homo sapiens_hsa052210.87616558
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87076276
60Axon guidance_Homo sapiens_hsa043600.85509866
61Osteoclast differentiation_Homo sapiens_hsa043800.84287027
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.83104509
63Other glycan degradation_Homo sapiens_hsa005110.81379817
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80196901
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79602193
66ErbB signaling pathway_Homo sapiens_hsa040120.78339313
67B cell receptor signaling pathway_Homo sapiens_hsa046620.75908762
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75857553
69Adherens junction_Homo sapiens_hsa045200.75591377
70Pancreatic cancer_Homo sapiens_hsa052120.74669692
71Vibrio cholerae infection_Homo sapiens_hsa051100.72925337
72MAPK signaling pathway_Homo sapiens_hsa040100.70562403
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69644677
74Glucagon signaling pathway_Homo sapiens_hsa049220.69014189
75AMPK signaling pathway_Homo sapiens_hsa041520.68236572
76Choline metabolism in cancer_Homo sapiens_hsa052310.67261036
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66922132
78Rap1 signaling pathway_Homo sapiens_hsa040150.66860861
79Bile secretion_Homo sapiens_hsa049760.66805355
80VEGF signaling pathway_Homo sapiens_hsa043700.65887478
81Inositol phosphate metabolism_Homo sapiens_hsa005620.65222783
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64873928
83Prolactin signaling pathway_Homo sapiens_hsa049170.64353313
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64304187
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62890442
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62610284
87Endocytosis_Homo sapiens_hsa041440.60376123
88Circadian rhythm_Homo sapiens_hsa047100.57703129
89Ras signaling pathway_Homo sapiens_hsa040140.57569902
90Renal cell carcinoma_Homo sapiens_hsa052110.57282178
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.57133485
92FoxO signaling pathway_Homo sapiens_hsa040680.56773391
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.55889298
94Insulin signaling pathway_Homo sapiens_hsa049100.54911423
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53957301
96Platelet activation_Homo sapiens_hsa046110.52903172
97Focal adhesion_Homo sapiens_hsa045100.52601691
98mTOR signaling pathway_Homo sapiens_hsa041500.52463153
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51387991
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50108675
101Amoebiasis_Homo sapiens_hsa051460.47708640
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46898802
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.46292906
104Ovarian steroidogenesis_Homo sapiens_hsa049130.45909921
105Fatty acid biosynthesis_Homo sapiens_hsa000610.44730672
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44465709
107Insulin resistance_Homo sapiens_hsa049310.43408628
108Chemokine signaling pathway_Homo sapiens_hsa040620.42533118
109ECM-receptor interaction_Homo sapiens_hsa045120.40736273
110African trypanosomiasis_Homo sapiens_hsa051430.40488535
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39682607
112Proteoglycans in cancer_Homo sapiens_hsa052050.38468143
113Endometrial cancer_Homo sapiens_hsa052130.38346353
114Prion diseases_Homo sapiens_hsa050200.36608493
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35102465
116Mineral absorption_Homo sapiens_hsa049780.33841991
117Protein digestion and absorption_Homo sapiens_hsa049740.33683752
118Tight junction_Homo sapiens_hsa045300.33335364
119Wnt signaling pathway_Homo sapiens_hsa043100.33241484

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