ZBTB32

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)6.88778771
2positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.90270665
3T cell lineage commitment (GO:0002360)4.82983833
4B cell receptor signaling pathway (GO:0050853)4.82686483
5nuclear pore complex assembly (GO:0051292)4.79428495
6cellular response to type I interferon (GO:0071357)4.65279123
7type I interferon signaling pathway (GO:0060337)4.65279123
8response to type I interferon (GO:0034340)4.64974775
9positive regulation of gamma-delta T cell activation (GO:0046645)4.53146819
10nuclear pore organization (GO:0006999)4.41381439
11piRNA metabolic process (GO:0034587)4.32743649
12interferon-gamma-mediated signaling pathway (GO:0060333)4.30078315
13regulation of interferon-gamma biosynthetic process (GO:0045072)4.28821777
14defense response to protozoan (GO:0042832)4.19238195
15myeloid dendritic cell differentiation (GO:0043011)4.15912084
16immunoglobulin mediated immune response (GO:0016064)4.04368734
17B cell homeostasis (GO:0001782)4.02279821
18response to protozoan (GO:0001562)4.00263083
19regulation of isotype switching to IgG isotypes (GO:0048302)3.84995466
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.84511261
21positive regulation of natural killer cell differentiation (GO:0032825)3.83125124
22regulation of gamma-delta T cell differentiation (GO:0045586)3.82643552
23regulation of chronic inflammatory response (GO:0002676)3.81018030
24cytidine deamination (GO:0009972)3.80044239
25cytidine metabolic process (GO:0046087)3.80044239
26cytidine catabolic process (GO:0006216)3.80044239
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.79799561
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.79799561
29positive regulation of B cell proliferation (GO:0030890)3.77413868
30myeloid dendritic cell activation (GO:0001773)3.77113751
31lymphocyte costimulation (GO:0031294)3.76687735
32antigen processing and presentation of endogenous antigen (GO:0019883)3.74250971
33T cell costimulation (GO:0031295)3.72937592
34regulation of B cell proliferation (GO:0030888)3.69511447
35negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.69361272
36negative regulation of cell killing (GO:0031342)3.69361272
37protein localization to kinetochore (GO:0034501)3.65580183
38regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.65160642
39antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.64583481
40B cell proliferation (GO:0042100)3.62562086
41protein localization to chromosome, centromeric region (GO:0071459)3.59674823
42pore complex assembly (GO:0046931)3.58653210
43positive regulation of interleukin-10 production (GO:0032733)3.56787484
44B cell mediated immunity (GO:0019724)3.54161534
45regulation of T-helper 1 cell differentiation (GO:0045625)3.53087001
46positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.50159364
47positive regulation of isotype switching (GO:0045830)3.49585165
48mitotic nuclear envelope disassembly (GO:0007077)3.46857655
49regulation of interleukin-12 biosynthetic process (GO:0045075)3.46470282
50synaptonemal complex assembly (GO:0007130)3.45167735
51positive regulation of B cell activation (GO:0050871)3.44611621
52positive regulation of cytokine biosynthetic process (GO:0042108)3.43838948
53regulation of B cell differentiation (GO:0045577)3.43578075
54male meiosis (GO:0007140)3.42881175
55negative T cell selection (GO:0043383)3.42531987
56positive regulation of interleukin-2 production (GO:0032743)3.42001362
57T-helper 1 type immune response (GO:0042088)3.41657751
58regulation of gamma-delta T cell activation (GO:0046643)3.41306701
59positive regulation of B cell differentiation (GO:0045579)3.40697292
60positive regulation of alpha-beta T cell proliferation (GO:0046641)3.39521142
61positive regulation by symbiont of host defense response (GO:0052509)3.39157821
62modulation by symbiont of host defense response (GO:0052031)3.39157821
63modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.39157821
64modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.39157821
65positive regulation by organism of defense response of other organism involved in symbiotic interact3.39157821
66modulation by symbiont of host immune response (GO:0052553)3.39157821
67pyrimidine ribonucleoside catabolic process (GO:0046133)3.37775021
68fusion of sperm to egg plasma membrane (GO:0007342)3.35999043
69regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.34415939
70synaptonemal complex organization (GO:0070193)3.31216182
71response to interleukin-15 (GO:0070672)3.30805881
72cellular response to interferon-gamma (GO:0071346)3.30684364
73positive regulation of B cell mediated immunity (GO:0002714)3.30216478
74positive regulation of immunoglobulin mediated immune response (GO:0002891)3.30216478
75sperm-egg recognition (GO:0035036)3.30156330
76negative thymic T cell selection (GO:0045060)3.29467746
77binding of sperm to zona pellucida (GO:0007339)3.28570308
78folic acid-containing compound biosynthetic process (GO:0009396)3.27651128
79positive regulation of interleukin-12 production (GO:0032735)3.27604724
80DNA replication-dependent nucleosome assembly (GO:0006335)3.26591368
81DNA replication-dependent nucleosome organization (GO:0034723)3.26591368
82positive regulation of interleukin-17 production (GO:0032740)3.26397739
83nuclear envelope disassembly (GO:0051081)3.21806499
84membrane disassembly (GO:0030397)3.21806499
85positive regulation of cell killing (GO:0031343)3.20457354
86positive regulation of lymphocyte mediated immunity (GO:0002708)3.18529161
87regulation of B cell activation (GO:0050864)3.17283253
88positive thymic T cell selection (GO:0045059)3.16481300
89positive regulation of interferon-alpha production (GO:0032727)3.16125397
90negative regulation of T cell mediated immunity (GO:0002710)3.16076149
91cilium or flagellum-dependent cell motility (GO:0001539)3.15134431
92cell-cell recognition (GO:0009988)3.14892050
93activated T cell proliferation (GO:0050798)3.13322152
94formation of translation preinitiation complex (GO:0001731)3.12956580
95activation of MAPKKK activity (GO:0000185)3.12942883
96regulation of interferon-alpha production (GO:0032647)3.12564725
97negative regulation of B cell proliferation (GO:0030889)3.12545570
98dendritic cell differentiation (GO:0097028)3.12216481
99heterochromatin organization (GO:0070828)3.12127066
100positive regulation of interferon-gamma production (GO:0032729)3.11781091
101positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.11774662
102regulation of T-helper cell differentiation (GO:0045622)3.11716491
103regulation of dendritic cell antigen processing and presentation (GO:0002604)3.11417761
104regulation of type I interferon-mediated signaling pathway (GO:0060338)3.11124452
105tolerance induction (GO:0002507)3.10516930
106regulation of interleukin-12 production (GO:0032655)3.09623845
107mitotic sister chromatid segregation (GO:0000070)3.09064933
108regulation of cell killing (GO:0031341)3.07923432
109regulation of interleukin-10 production (GO:0032653)3.05434201
110DNA unwinding involved in DNA replication (GO:0006268)3.03156858
111positive regulation of immune response to tumor cell (GO:0002839)3.03105984
112regulation of immune response to tumor cell (GO:0002837)3.03105984
113regulation of response to tumor cell (GO:0002834)3.03105984
114positive regulation of response to tumor cell (GO:0002836)3.03105984
115lymphocyte homeostasis (GO:0002260)2.99473259
116mitotic chromosome condensation (GO:0007076)2.97883138
117positive regulation of natural killer cell mediated immunity (GO:0002717)2.96825609
118positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.96825609
119gene silencing by RNA (GO:0031047)2.94292179
120positive regulation of humoral immune response (GO:0002922)2.91815486
121thymic T cell selection (GO:0045061)2.91780415
122regulation of histone H3-K9 methylation (GO:0051570)2.90975433
123DNA duplex unwinding (GO:0032508)2.90085536
124DNA replication initiation (GO:0006270)2.88571548
125positive regulation of immunoglobulin production (GO:0002639)2.88413941
126regulation of interleukin-2 biosynthetic process (GO:0045076)2.87472291
127DNA geometric change (GO:0032392)2.87181501
128sister chromatid segregation (GO:0000819)2.82754611
129positive regulation of DNA recombination (GO:0045911)2.82499359
130interferon-gamma production (GO:0032609)2.80887616
131meiotic nuclear division (GO:0007126)2.80703590
132cellular response to interleukin-15 (GO:0071350)2.78968432
133ribosome biogenesis (GO:0042254)2.77508617
134regulation of B cell receptor signaling pathway (GO:0050855)2.77054356
135chromosome organization involved in meiosis (GO:0070192)2.76844896
136regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.76690754
137regulation of natural killer cell mediated immunity (GO:0002715)2.76690754
138chromosome condensation (GO:0030261)2.74800001
139mitotic sister chromatid cohesion (GO:0007064)2.72902388
140sperm motility (GO:0030317)2.72402322
141maturation of SSU-rRNA (GO:0030490)2.71899478
142DNA methylation involved in gamete generation (GO:0043046)2.70522959
143DNA strand elongation involved in DNA replication (GO:0006271)2.70321560
144somatic diversification of immune receptors via somatic mutation (GO:0002566)2.69408132
145somatic hypermutation of immunoglobulin genes (GO:0016446)2.69408132
146regulation of translational termination (GO:0006449)2.69196403
147negative regulation of histone methylation (GO:0031061)2.66490497
148DNA packaging (GO:0006323)2.65027103
149regulation of immunoglobulin mediated immune response (GO:0002889)2.63860008
150regulation of alpha-beta T cell proliferation (GO:0046640)2.63661606
151regulation of regulatory T cell differentiation (GO:0045589)2.62633262
152regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.62361237
153pre-miRNA processing (GO:0031054)2.62125803
154T cell selection (GO:0045058)2.61178674
155positive T cell selection (GO:0043368)2.60920665
156DNA conformation change (GO:0071103)2.60517845
157regulation of B cell mediated immunity (GO:0002712)2.58610377
158spermatid development (GO:0007286)2.58588918
159regulation of translation in response to stress (GO:0043555)2.58266771
160nucleobase biosynthetic process (GO:0046112)2.57654662
161T cell migration (GO:0072678)2.57299785
162motile cilium assembly (GO:0044458)2.56104592
163chromatin assembly (GO:0031497)2.55760781
164multicellular organism reproduction (GO:0032504)2.54914922
165meiotic chromosome segregation (GO:0045132)2.52835761
166DNA strand elongation (GO:0022616)2.52204817
167negative regulation of B cell apoptotic process (GO:0002903)2.50828122
168regulation of translational fidelity (GO:0006450)2.50245723
169NIK/NF-kappaB signaling (GO:0038061)2.48649936

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.16253096
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.99476395
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.65220019
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.61592155
5MYC_22102868_ChIP-Seq_BL_Human3.07141820
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.95235510
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.93617875
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.56875096
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.56500528
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.49303784
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.45929229
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.36534591
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.33244913
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.21937412
15* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.04751431
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.01152067
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.96992129
18VDR_24763502_ChIP-Seq_THP-1_Human1.94512387
19* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.90526222
20MYC_18358816_ChIP-ChIP_MESCs_Mouse1.89663449
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.87406508
22MYB_26560356_Chip-Seq_TH2_Human1.80096174
23* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.78213777
24* MYB_26560356_Chip-Seq_TH1_Human1.76099621
25* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75570647
26GATA1_22025678_ChIP-Seq_K562_Human1.73729542
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.72296865
28VDR_23849224_ChIP-Seq_CD4+_Human1.66587464
29VDR_21846776_ChIP-Seq_THP-1_Human1.66377067
30XRN2_22483619_ChIP-Seq_HELA_Human1.65477378
31MAF_26560356_Chip-Seq_TH1_Human1.62978177
32SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.62723791
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61888577
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.61060185
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.60346439
36STAT3_1855785_ChIP-Seq_MESCs_Mouse1.57948479
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56943420
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.56574645
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56498896
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53787689
41FOXP3_21729870_ChIP-Seq_TREG_Human1.50455980
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48769855
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.48592403
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48333895
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47970667
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.45679801
47UTX_26944678_Chip-Seq_JUKART_Human1.44132711
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.44050768
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.43855861
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42128537
51KDM5A_27292631_Chip-Seq_BREAST_Human1.41986526
52* MAF_26560356_Chip-Seq_TH2_Human1.41903879
53VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.41441586
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.41027171
55LXR_22292898_ChIP-Seq_THP-1_Human1.38824154
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.38617815
57SCL_19346495_ChIP-Seq_HPC-7_Human1.36343789
58NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.35915168
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34493351
60CIITA_25753668_ChIP-Seq_RAJI_Human1.34175660
61* IRF8_21731497_ChIP-ChIP_J774_Mouse1.34038649
62FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32993962
63GATA3_26560356_Chip-Seq_TH2_Human1.32887212
64CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32280384
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30627155
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28551483
67AR_21909140_ChIP-Seq_LNCAP_Human1.27897741
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27335307
69TCF7_22412390_ChIP-Seq_EML_Mouse1.26848670
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23481167
71CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.23294554
72GABP_19822575_ChIP-Seq_HepG2_Human1.20224858
73* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19396594
74MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19214332
75* SPI1_23547873_ChIP-Seq_NB4_Human1.18171396
76DCP1A_22483619_ChIP-Seq_HELA_Human1.18168524
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18149571
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17757673
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.17383357
80KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.17383357
81KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.17383357
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16911691
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15933634
84RUNX1_22412390_ChIP-Seq_EML_Mouse1.15724714
85E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14171011
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13969401
87NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.12219217
88E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12172148
89KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11600529
90ELF1_20517297_ChIP-Seq_JURKAT_Human1.11289786
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07353037
92PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07206258
93CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07165816
94RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06000013
95TTF2_22483619_ChIP-Seq_HELA_Human1.05478468
96MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04085799
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03774868
98MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02651155
99KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01979425
100BCL6_27268052_Chip-Seq_Bcells_Human1.01093335
101ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00975853
102SPI1_23127762_ChIP-Seq_K562_Human0.99701584
103GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99525240
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99392157
105DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99160904
106IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98997883
107SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97574606
108TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97441302
109BRD4_27068464_Chip-Seq_AML-cells_Mouse0.95419033
110NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95360468
111BCOR_27268052_Chip-Seq_Bcells_Human0.95180509
112GATA3_27048872_Chip-Seq_THYMUS_Human0.94673521
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94654190
114MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.94588129
115ELF1_17652178_ChIP-ChIP_JURKAT_Human0.93244931
116SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93162890
117PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92984972
118CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91872540
119E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90953656
120GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90260573
121EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90139119
122BP1_19119308_ChIP-ChIP_Hs578T_Human0.90043316
123RUNX_20019798_ChIP-Seq_JUKART_Human0.89991413
124PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89322377
125ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89116943
126E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89097825
127GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88140004
128ELK1_19687146_ChIP-ChIP_HELA_Human0.87601333
129CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86844135
130* KDM2B_26808549_Chip-Seq_DND41_Human0.86729111
131TP63_19390658_ChIP-ChIP_HaCaT_Human0.86245875
132YY1_21170310_ChIP-Seq_MESCs_Mouse0.85343954
133PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85291750
134* IRF8_27001747_Chip-Seq_BMDM_Mouse0.85012366
135BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84981298
136HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.84625292
137P300_27268052_Chip-Seq_Bcells_Human0.84130440
138HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83551325
139CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81881112
140VDR_24787735_ChIP-Seq_THP-1_Human0.80198492
141IRF1_19129219_ChIP-ChIP_H3396_Human0.80093765
142ELK3_25401928_ChIP-Seq_HUVEC_Human0.79934886
143NCOR1_26117541_ChIP-Seq_K562_Human0.77804828

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.88016820
2MP0005410_abnormal_fertilization3.33128189
3MP0003693_abnormal_embryo_hatching3.21464712
4MP0003763_abnormal_thymus_physiology3.12586863
5MP0001835_abnormal_antigen_presentation3.10245206
6MP0010094_abnormal_chromosome_stability3.04527601
7MP0002138_abnormal_hepatobiliary_system2.82492983
8MP0005671_abnormal_response_to2.82257617
9MP0001800_abnormal_humoral_immune2.81825527
10MP0004957_abnormal_blastocyst_morpholog2.75985100
11MP0003111_abnormal_nucleus_morphology2.70637027
12MP0008877_abnormal_DNA_methylation2.67195024
13MP0001790_abnormal_immune_system2.63317935
14MP0005387_immune_system_phenotype2.63317935
15MP0003077_abnormal_cell_cycle2.62505404
16MP0000685_abnormal_immune_system2.60966004
17MP0001348_abnormal_lacrimal_gland2.59301193
18MP0003300_gastrointestinal_ulcer2.32620005
19MP0010352_gastrointestinal_tract_polyps2.21603104
20* MP0002398_abnormal_bone_marrow2.19613862
21MP0009333_abnormal_splenocyte_physiolog2.12876813
22MP0002396_abnormal_hematopoietic_system2.09166605
23MP0002405_respiratory_system_inflammati2.07516187
24MP0002452_abnormal_antigen_presenting2.04297813
25* MP0002723_abnormal_immune_serum2.02279755
26MP0005000_abnormal_immune_tolerance2.01392214
27MP0010307_abnormal_tumor_latency1.99343563
28MP0008058_abnormal_DNA_repair1.98349894
29* MP0002420_abnormal_adaptive_immunity1.95515584
30MP0000689_abnormal_spleen_morphology1.92918187
31MP0003436_decreased_susceptibility_to1.91268288
32* MP0001819_abnormal_immune_cell1.91052804
33MP0001929_abnormal_gametogenesis1.84964175
34MP0000703_abnormal_thymus_morphology1.82500755
35* MP0000716_abnormal_immune_system1.81751636
36MP0002722_abnormal_immune_system1.79709894
37MP0001730_embryonic_growth_arrest1.67381811
38MP0000350_abnormal_cell_proliferation1.64783999
39MP0001873_stomach_inflammation1.64392140
40MP0002210_abnormal_sex_determination1.61947873
41* MP0002429_abnormal_blood_cell1.60991438
42MP0006082_CNS_inflammation1.60839683
43MP0005025_abnormal_response_to1.59812383
44MP0005076_abnormal_cell_differentiation1.59205855
45MP0002163_abnormal_gland_morphology1.58951077
46MP0005451_abnormal_body_composition1.57396999
47MP0001853_heart_inflammation1.56388720
48MP0003045_fibrosis1.53750181
49MP0003303_peritoneal_inflammation1.53716787
50MP0002019_abnormal_tumor_incidence1.50809027
51MP0009785_altered_susceptibility_to1.49978006
52MP0010155_abnormal_intestine_physiology1.47353091
53MP0003698_abnormal_male_reproductive1.45840020
54MP0005645_abnormal_hypothalamus_physiol1.45315992
55MP0003448_altered_tumor_morphology1.40782194
56MP0003866_abnormal_defecation1.40743042
57MP0008007_abnormal_cellular_replicative1.39578432
58MP0004808_abnormal_hematopoietic_stem1.38487160
59MP0001145_abnormal_male_reproductive1.37235449
60MP0003786_premature_aging1.35945050
61MP0001672_abnormal_embryogenesis/_devel1.23019641
62MP0005380_embryogenesis_phenotype1.23019641
63MP0000490_abnormal_crypts_of1.22598679
64MP0001845_abnormal_inflammatory_respons1.18994131
65MP0000858_altered_metastatic_potential1.14574932
66MP0003984_embryonic_growth_retardation1.13784079
67MP0004381_abnormal_hair_follicle1.13757703
68MP0008932_abnormal_embryonic_tissue1.13595508
69MP0002088_abnormal_embryonic_growth/wei1.12545303
70MP0000313_abnormal_cell_death1.12459515
71MP0000653_abnormal_sex_gland1.11485134
72MP0002166_altered_tumor_susceptibility1.09494055
73MP0004947_skin_inflammation1.09050730
74MP0001697_abnormal_embryo_size1.08796792
75MP0002933_joint_inflammation1.08275203
76MP0002080_prenatal_lethality1.03959487
77MP0002086_abnormal_extraembryonic_tissu1.02534724
78MP0004197_abnormal_fetal_growth/weight/1.01877083
79MP0002148_abnormal_hypersensitivity_rea1.01485819
80MP0003724_increased_susceptibility_to1.01073443
81MP0002006_tumorigenesis0.99513309
82MP0002653_abnormal_ependyma_morphology0.98593835
83MP0003183_abnormal_peptide_metabolism0.98033075
84MP0002693_abnormal_pancreas_physiology0.96287554
85MP0002161_abnormal_fertility/fecundity0.91144915
86MP0002419_abnormal_innate_immunity0.91028283
87MP0005623_abnormal_meninges_morphology0.90484742
88MP0003091_abnormal_cell_migration0.90206208
89MP0005023_abnormal_wound_healing0.88351683
90MP0002085_abnormal_embryonic_tissue0.82840219
91MP0000465_gastrointestinal_hemorrhage0.80442679
92MP0003806_abnormal_nucleotide_metabolis0.80019566
93MP0008961_abnormal_basal_metabolism0.79437993
94MP0001533_abnormal_skeleton_physiology0.79055971
95MP0002084_abnormal_developmental_patter0.78906902
96MP0000372_irregular_coat_pigmentation0.77913905
97MP0002139_abnormal_hepatobiliary_system0.77163423
98MP0003890_abnormal_embryonic-extraembry0.75517149
99MP0001663_abnormal_digestive_system0.73865769
100MP0003566_abnormal_cell_adhesion0.72631237
101MP0005397_hematopoietic_system_phenotyp0.72563059
102MP0001545_abnormal_hematopoietic_system0.72563059
103MP0008995_early_reproductive_senescence0.70476414
104MP0005379_endocrine/exocrine_gland_phen0.70458640
105MP0009764_decreased_sensitivity_to0.70184385
106MP0005310_abnormal_salivary_gland0.69053422
107MP0008469_abnormal_protein_level0.67378200
108MP0001346_abnormal_lacrimal_gland0.66586015
109MP0003123_paternal_imprinting0.66435768
110MP0002132_abnormal_respiratory_system0.64907597
111MP0005621_abnormal_cell_physiology0.64518235
112MP0002998_abnormal_bone_remodeling0.63856580
113MP0005670_abnormal_white_adipose0.63254714
114MP0005464_abnormal_platelet_physiology0.63254349
115MP0003705_abnormal_hypodermis_morpholog0.62969872
116MP0009763_increased_sensitivity_to0.61748933
117MP0001119_abnormal_female_reproductive0.59509013
118MP0008872_abnormal_physiological_respon0.59063039
119MP0005166_decreased_susceptibility_to0.58968125
120MP0000371_diluted_coat_color0.56842803
121MP0005384_cellular_phenotype0.55033141
122MP0000477_abnormal_intestine_morphology0.54868285
123MP0002136_abnormal_kidney_physiology0.54709185
124MP0004510_myositis0.54693963
125MP0005647_abnormal_sex_gland0.53565201
126MP0001727_abnormal_embryo_implantation0.53554703
127MP0002928_abnormal_bile_duct0.52056459
128MP0008874_decreased_physiological_sensi0.51892435
129MP0000609_abnormal_liver_physiology0.49204273
130MP0008004_abnormal_stomach_pH0.48263716
131MP0001919_abnormal_reproductive_system0.48011972
132MP0005075_abnormal_melanosome_morpholog0.44330836
133MP0009765_abnormal_xenobiotic_induced0.41733302
134MP0005394_taste/olfaction_phenotype0.39614424
135MP0005499_abnormal_olfactory_system0.39614424
136MP0002877_abnormal_melanocyte_morpholog0.39586975
137MP0003453_abnormal_keratinocyte_physiol0.39091737
138MP0003315_abnormal_perineum_morphology0.37654975
139MP0006035_abnormal_mitochondrial_morpho0.37015111

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)6.45047378
2Recurrent bronchitis (HP:0002837)5.29507179
3Abnormality of the nasal mucosa (HP:0000433)5.17226523
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.28313499
5Bronchitis (HP:0012387)4.19532003
6Increased IgM level (HP:0003496)4.00992377
7Recurrent sinusitis (HP:0011108)3.97226633
8Recurrent cutaneous fungal infections (HP:0011370)3.85917631
9Chronic mucocutaneous candidiasis (HP:0002728)3.85917631
10T lymphocytopenia (HP:0005403)3.70312389
11Retrobulbar optic neuritis (HP:0100654)3.68981024
12Optic neuritis (HP:0100653)3.68981024
13Autoimmune hemolytic anemia (HP:0001890)3.67337221
14IgM deficiency (HP:0002850)3.61755694
15Abnormality of T cell number (HP:0011839)3.52152330
16Restrictive lung disease (HP:0002091)3.30023742
17Recurrent viral infections (HP:0004429)3.27453794
18Rhinitis (HP:0012384)3.23784128
19Abnormality of T cells (HP:0002843)3.20357989
20Absent/shortened dynein arms (HP:0200106)3.19917107
21Dynein arm defect of respiratory motile cilia (HP:0012255)3.19917107
22Bronchiectasis (HP:0002110)3.18607395
23Recurrent lower respiratory tract infections (HP:0002783)3.14715750
24Orchitis (HP:0100796)3.13835624
25Encephalitis (HP:0002383)3.10725743
26Recurrent otitis media (HP:0000403)3.09928379
27Recurrent pneumonia (HP:0006532)3.01148348
28Gastrointestinal inflammation (HP:0004386)2.87583900
29Gastrointestinal infarctions (HP:0005244)2.86077165
30Inflammation of the large intestine (HP:0002037)2.85748504
31Recurrent bacterial skin infections (HP:0005406)2.81027346
32Chronic otitis media (HP:0000389)2.80077780
33IgA deficiency (HP:0002720)2.76654945
34Abnormality of the lower motor neuron (HP:0002366)2.76562014
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.75942521
36Ependymoma (HP:0002888)2.71614699
37Abnormality of the prostate (HP:0008775)2.71555540
38Hemoptysis (HP:0002105)2.68581085
39Chronic sinusitis (HP:0011109)2.67331423
40Recurrent skin infections (HP:0001581)2.65320100
41Agammaglobulinemia (HP:0004432)2.65161665
42Abnormality of T cell physiology (HP:0011840)2.64098794
43Basal cell carcinoma (HP:0002671)2.61670249
44Panhypogammaglobulinemia (HP:0003139)2.61044631
45Recurrent fungal infections (HP:0002841)2.59143334
46Impulsivity (HP:0100710)2.57882552
47Keratoconjunctivitis sicca (HP:0001097)2.56986836
48Abnormality of macrophages (HP:0004311)2.55632079
49Chronic bronchitis (HP:0004469)2.54569239
50Obstructive lung disease (HP:0006536)2.54468546
51Chronic obstructive pulmonary disease (HP:0006510)2.54468546
52Joint swelling (HP:0001386)2.53071808
53Colitis (HP:0002583)2.52201489
54Combined immunodeficiency (HP:0005387)2.51324751
55Autoimmune thrombocytopenia (HP:0001973)2.47582990
56Abnormality of the anterior horn cell (HP:0006802)2.46806279
57Degeneration of anterior horn cells (HP:0002398)2.46806279
58Arthralgia (HP:0002829)2.46561851
59Abnormal respiratory motile cilium physiology (HP:0012261)2.46258013
60Osteomyelitis (HP:0002754)2.45991863
61Thrombocytosis (HP:0001894)2.44665801
62Abnormality of male internal genitalia (HP:0000022)2.44207184
63Xerostomia (HP:0000217)2.43895794
64Skin rash (HP:0000988)2.43316910
65Lymphoma (HP:0002665)2.41986481
66Hypergammaglobulinemia (HP:0010702)2.41118094
67Selective tooth agenesis (HP:0001592)2.39861041
68Chromsome breakage (HP:0040012)2.38770551
69Abnormality of the pleura (HP:0002103)2.37402943
70Abnormality of cells of the lymphoid lineage (HP:0012140)2.35252818
71Hypertensive crisis (HP:0100735)2.35099668
72Keratoconjunctivitis (HP:0001096)2.35048507
73Gangrene (HP:0100758)2.34879601
74Lymphopenia (HP:0001888)2.34722575
75Cellulitis (HP:0100658)2.34564977
76Recurrent abscess formation (HP:0002722)2.34511389
77Urticaria (HP:0001025)2.33574241
78Chromosomal breakage induced by crosslinking agents (HP:0003221)2.32636381
79Arterial thrombosis (HP:0004420)2.30264162
80Small epiphyses (HP:0010585)2.30155989
81Hypoplasia of the capital femoral epiphysis (HP:0003090)2.27191776
82Amyotrophic lateral sclerosis (HP:0007354)2.23980735
83Medulloblastoma (HP:0002885)2.21361185
84Amaurosis fugax (HP:0100576)2.21120034
85Leukopenia (HP:0001882)2.19865823
86IgG deficiency (HP:0004315)2.19628265
87Myelodysplasia (HP:0002863)2.18700589
88Chest pain (HP:0100749)2.18614197
89Abnormal respiratory epithelium morphology (HP:0012253)2.18287372
90Abnormal respiratory motile cilium morphology (HP:0005938)2.18287372
91Eczematoid dermatitis (HP:0000976)2.17281734
92Prominent nose (HP:0000448)2.17181544
93Granulocytopenia (HP:0001913)2.16739300
94Severe combined immunodeficiency (HP:0004430)2.16319445
95Meningitis (HP:0001287)2.16105871
96Absent epiphyses (HP:0010577)2.15793133
97Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.15793133
98Absent frontal sinuses (HP:0002688)2.15193961
99Multiple enchondromatosis (HP:0005701)2.13327279
100Elevated erythrocyte sedimentation rate (HP:0003565)2.11906605
101Rhabdomyosarcoma (HP:0002859)2.11061881
102Abnormality of B cell number (HP:0010975)2.09534558
103B lymphocytopenia (HP:0010976)2.09534558
104Abnormality of chromosome stability (HP:0003220)2.09504116
105Hepatitis (HP:0012115)2.09499672
106Pulmonary fibrosis (HP:0002206)2.07730002
107Irregular epiphyses (HP:0010582)2.07026263
108Flattened epiphyses (HP:0003071)2.07024548
109Polyneuropathy (HP:0001271)2.06598464
110Mediastinal lymphadenopathy (HP:0100721)2.05609336
111Stomatitis (HP:0010280)2.05354698
112Fatigue (HP:0012378)2.05324065
113Myositis (HP:0100614)2.04339917
114Vasculitis (HP:0002633)2.04329122
115Gastrointestinal stroma tumor (HP:0100723)2.03614307
116Abnormality of the fingertips (HP:0001211)2.02422728
117Hypoplasia of the uterus (HP:0000013)2.02244156
118Emphysema (HP:0002097)2.01263590
119Acute hepatic failure (HP:0006554)2.00629372
120Heterotopia (HP:0002282)2.00016317
121Skin ulcer (HP:0200042)1.99857768
122Carpal bone hypoplasia (HP:0001498)1.99659823
123Sepsis (HP:0100806)1.98836811
124Birth length less than 3rd percentile (HP:0003561)1.97114664
125Ureteral stenosis (HP:0000071)1.96763712
126Neoplasm of striated muscle (HP:0009728)1.96614804
127Viral hepatitis (HP:0006562)1.96227750
128Aplasia/Hypoplasia of the uvula (HP:0010293)1.95324296
129Infertility (HP:0000789)1.95016394
130Increased density of long bones (HP:0006392)1.94975740
131Neutropenia (HP:0001875)1.94711805
132Pulmonary embolism (HP:0002204)1.92986330
133Premature loss of primary teeth (HP:0006323)1.91711790
134Verrucae (HP:0200043)1.91000488
135Papilloma (HP:0012740)1.91000488
136Ureteral obstruction (HP:0006000)1.89592093
13711 pairs of ribs (HP:0000878)1.88147793
138Reticulocytopenia (HP:0001896)1.86433186
139Abnormality of the preputium (HP:0100587)1.86253250
140Supernumerary spleens (HP:0009799)1.85585194
141Sloping forehead (HP:0000340)1.85179053
142Abnormal spermatogenesis (HP:0008669)1.84994438
143Meckel diverticulum (HP:0002245)1.83801061
144Absent thumb (HP:0009777)1.81302299
145Atrophy/Degeneration involving motor neurons (HP:0007373)1.79888910
146Ectopic kidney (HP:0000086)1.79821630
147Abnormality of the ileum (HP:0001549)1.78460168
148Pulmonary infiltrates (HP:0002113)1.77637523
149Increased IgE level (HP:0003212)1.77106935
150Persistence of primary teeth (HP:0006335)1.77022740
151Chronic diarrhea (HP:0002028)1.76512750
152Squamous cell carcinoma (HP:0002860)1.76391375

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.38018062
2RIPK44.18409540
3PRPF4B3.86849103
4CDK123.74853832
5STK102.76586363
6CDC72.65291775
7PDK42.64719759
8PDK32.64719759
9JAK32.61099596
10NEK22.42656558
11IRAK42.26053180
12EEF2K2.22658972
13MAP3K132.20349681
14TXK2.11193503
15SMG11.95880773
16GRK61.90379912
17NEK91.77646869
18TESK11.75584965
19MAP3K101.73357412
20ITK1.66481536
21TLK11.61994761
22BUB11.59839593
23ZAP701.59111615
24MAP3K141.57523086
25ALK1.56537601
26PDK21.55583950
27CSF1R1.55054983
28TYK21.51002261
29SIK31.48926024
30EIF2AK11.48185757
31WEE11.44509281
32TTK1.38932626
33CSK1.38625654
34MST41.36689683
35KIT1.35782141
36PASK1.33404741
37TESK21.31771117
38MAPK111.29186747
39ICK1.28649960
40BMPR21.27971652
41BLK1.26742595
42ERN11.25506913
43TSSK61.24429372
44CHEK11.24318084
45PIM11.23969049
46CDK41.21407400
47PINK11.19418235
48RPS6KA51.19259743
49NME11.17610130
50FGFR41.14560911
51TRIB31.12635741
52TAOK21.09493038
53ATR1.08779929
54CDC42BPA1.08587928
55IKBKB1.08393193
56BTK1.07164059
57SYK1.06829414
58PLK11.04960320
59MAP3K81.03320041
60CDK71.02746758
61LRRK21.02520377
62CHUK1.01315843
63LCK0.99894564
64CHEK20.99747116
65BRD40.93745076
66JAK10.92729242
67MAP3K90.92594866
68RPS6KB20.92352386
69NME20.91305429
70RPS6KA40.89382423
71EIF2AK30.86882058
72AURKB0.84884505
73MATK0.83314764
74IKBKE0.82071114
75MARK30.81929597
76TYRO30.80612896
77HCK0.79652212
78ZAK0.78998784
79PRKD30.78673497
80PNCK0.76061928
81TAOK10.74393847
82ARAF0.74181963
83MELK0.73337516
84TBK10.73117578
85MTOR0.72874344
86STK240.71218301
87EPHB10.70199880
88ATM0.68566096
89PRKCH0.68517712
90SIK20.66575521
91PLK40.65984705
92CDK20.65121197
93SRPK10.64982589
94FGR0.64644198
95STK40.64554722
96FGFR30.64016861
97VRK10.63177830
98PIM20.62751516
99NEK10.61978870
100PKN20.61832684
101CLK10.59662545
102PRKCQ0.59056067
103PDK10.55565824
104EPHA30.54180424
105MAP3K30.52449237
106SIK10.50852242
107MAPK120.50846855
108KSR20.49567364
109TEC0.49273116
110MAPKAPK30.47562184
111LYN0.46578384
112HIPK20.45940452
113IRAK30.45218401
114AURKA0.44260158
115KDR0.43088685
116IRAK10.42396265
117CDK60.42113689
118PLK30.41265938
119MAP2K60.41073080
120DAPK30.40027606
121PAK10.39957106
122STK30.39596933
123TNK20.39278430
124MAP3K70.38754475
125CDK10.38510122
126CCNB10.38330789
127NLK0.38269284
128SCYL20.37330481
129MAP3K110.37075267
130PDPK10.35182471
131CSNK2A20.34669322
132BMX0.34554762
133PAK40.34035837
134MAP3K10.33974467
135RAF10.33915847
136PKN10.33528544
137JAK20.33452269
138EGFR0.33332792
139DDR20.32311850
140CDK90.31881324
141MAP3K50.31448805
142MAPK40.30806231
143FES0.29785416
144TAF10.29072808
145MAPKAPK20.28884309
146WNK10.28668936
147BRAF0.27304538
148IRAK20.26858725
149PRKCI0.21211448
150MAPK70.20814294

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.29696462
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.19544232
3Primary immunodeficiency_Homo sapiens_hsa053403.07141573
4DNA replication_Homo sapiens_hsa030303.03444066
5Allograft rejection_Homo sapiens_hsa053302.99470358
6Mismatch repair_Homo sapiens_hsa034302.71929813
7RNA transport_Homo sapiens_hsa030132.46479649
8Type I diabetes mellitus_Homo sapiens_hsa049402.36792836
9Antigen processing and presentation_Homo sapiens_hsa046122.35482396
10One carbon pool by folate_Homo sapiens_hsa006702.28945682
11T cell receptor signaling pathway_Homo sapiens_hsa046602.12278121
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.03902417
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.02669498
14Base excision repair_Homo sapiens_hsa034102.02307166
15Spliceosome_Homo sapiens_hsa030401.96893893
16B cell receptor signaling pathway_Homo sapiens_hsa046621.92881164
17Autoimmune thyroid disease_Homo sapiens_hsa053201.88837000
18Homologous recombination_Homo sapiens_hsa034401.88267139
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81273576
20Measles_Homo sapiens_hsa051621.77360160
21Fanconi anemia pathway_Homo sapiens_hsa034601.73371659
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.65021251
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.62802605
24Ribosome_Homo sapiens_hsa030101.58658499
25mRNA surveillance pathway_Homo sapiens_hsa030151.57968315
26Cell cycle_Homo sapiens_hsa041101.56182091
27Nucleotide excision repair_Homo sapiens_hsa034201.54386907
28Proteasome_Homo sapiens_hsa030501.53556312
29Herpes simplex infection_Homo sapiens_hsa051681.50132003
30Staphylococcus aureus infection_Homo sapiens_hsa051501.42202676
31RNA degradation_Homo sapiens_hsa030181.41036618
32Epstein-Barr virus infection_Homo sapiens_hsa051691.37835334
33Rheumatoid arthritis_Homo sapiens_hsa053231.35036673
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.33368556
35Basal transcription factors_Homo sapiens_hsa030221.31154718
36RNA polymerase_Homo sapiens_hsa030201.30971256
37Hematopoietic cell lineage_Homo sapiens_hsa046401.25988179
38Viral carcinogenesis_Homo sapiens_hsa052031.20737283
39Asthma_Homo sapiens_hsa053101.19200739
40Non-homologous end-joining_Homo sapiens_hsa034501.13557589
41HTLV-I infection_Homo sapiens_hsa051661.12818044
42Pyrimidine metabolism_Homo sapiens_hsa002401.10480010
43Legionellosis_Homo sapiens_hsa051341.08023387
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.05404140
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03289485
46Apoptosis_Homo sapiens_hsa042101.02906470
47p53 signaling pathway_Homo sapiens_hsa041151.01556367
48Leishmaniasis_Homo sapiens_hsa051401.01545314
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01391486
50Acute myeloid leukemia_Homo sapiens_hsa052211.00503582
51Viral myocarditis_Homo sapiens_hsa054160.92800180
52Osteoclast differentiation_Homo sapiens_hsa043800.91371052
53Influenza A_Homo sapiens_hsa051640.87472699
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85540937
55Selenocompound metabolism_Homo sapiens_hsa004500.84561380
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84124292
57Hepatitis C_Homo sapiens_hsa051600.81127728
58Pentose phosphate pathway_Homo sapiens_hsa000300.80357962
59Hepatitis B_Homo sapiens_hsa051610.76992782
60Biosynthesis of amino acids_Homo sapiens_hsa012300.75857836
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74216820
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72505208
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71372385
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71243585
65Toxoplasmosis_Homo sapiens_hsa051450.71112131
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70353871
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70226554
68Alcoholism_Homo sapiens_hsa050340.68901566
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.67630417
70Phagosome_Homo sapiens_hsa041450.67011931
71African trypanosomiasis_Homo sapiens_hsa051430.66648912
72Vitamin B6 metabolism_Homo sapiens_hsa007500.64948979
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64666837
74TNF signaling pathway_Homo sapiens_hsa046680.61792719
75Shigellosis_Homo sapiens_hsa051310.60846959
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59880742
77Chronic myeloid leukemia_Homo sapiens_hsa052200.59394872
78Small cell lung cancer_Homo sapiens_hsa052220.56735168
79Systemic lupus erythematosus_Homo sapiens_hsa053220.56236376
80MicroRNAs in cancer_Homo sapiens_hsa052060.50901658
81HIF-1 signaling pathway_Homo sapiens_hsa040660.50803760
82Chemokine signaling pathway_Homo sapiens_hsa040620.50790348
83mTOR signaling pathway_Homo sapiens_hsa041500.49086560
84Dorso-ventral axis formation_Homo sapiens_hsa043200.47980298
85Fructose and mannose metabolism_Homo sapiens_hsa000510.45493052
86Oocyte meiosis_Homo sapiens_hsa041140.42746691
87VEGF signaling pathway_Homo sapiens_hsa043700.41581263
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41097977
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.40823410
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40559925
91Pancreatic cancer_Homo sapiens_hsa052120.39047744
92Purine metabolism_Homo sapiens_hsa002300.38660590
93Prolactin signaling pathway_Homo sapiens_hsa049170.36996875
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.36352720
95Tuberculosis_Homo sapiens_hsa051520.36166681
96Malaria_Homo sapiens_hsa051440.34542840
97Notch signaling pathway_Homo sapiens_hsa043300.34171632
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.33739612
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33239046
100Salmonella infection_Homo sapiens_hsa051320.32793834
101Fatty acid biosynthesis_Homo sapiens_hsa000610.32744701
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28792747
103MAPK signaling pathway_Homo sapiens_hsa040100.28507145
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27318738
105Non-small cell lung cancer_Homo sapiens_hsa052230.26545114
106Prostate cancer_Homo sapiens_hsa052150.26438250
107Lysine degradation_Homo sapiens_hsa003100.26339665
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.25528780
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.24972220
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24850598
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24727923
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24542251
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.17432084
114Insulin resistance_Homo sapiens_hsa049310.09764155
115Type II diabetes mellitus_Homo sapiens_hsa049300.09265046
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.08753359
117Pertussis_Homo sapiens_hsa051330.08210799
118FoxO signaling pathway_Homo sapiens_hsa040680.06646884
119Colorectal cancer_Homo sapiens_hsa052100.03344010
120Gap junction_Homo sapiens_hsa045400.03205485
121Endometrial cancer_Homo sapiens_hsa052130.01658316
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.01549802
123Sulfur relay system_Homo sapiens_hsa041220.01514955

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