ZBTB17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive thymic T cell selection (GO:0045059)7.23741628
2fat-soluble vitamin biosynthetic process (GO:0042362)7.10260645
3positive T cell selection (GO:0043368)5.56685694
4protein-DNA complex disassembly (GO:0032986)5.23173119
5nucleosome disassembly (GO:0006337)5.23173119
6regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)5.02819285
7peptidyl-arginine omega-N-methylation (GO:0035247)4.93066114
8response to peptidoglycan (GO:0032494)4.80488343
9cardiac ventricle formation (GO:0003211)4.74653545
10negative regulation of interleukin-12 production (GO:0032695)4.56024047
11regulation of translation in response to stress (GO:0043555)4.47721978
12peptidyl-arginine methylation (GO:0018216)4.35755115
13peptidyl-arginine N-methylation (GO:0035246)4.35755115
14cardiac chamber formation (GO:0003207)4.30404052
15positive regulation of gamma-delta T cell activation (GO:0046645)4.22550407
16negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.19314965
17response to muramyl dipeptide (GO:0032495)4.18891770
18secondary heart field specification (GO:0003139)4.13731202
19heart field specification (GO:0003128)4.13731202
20negative regulation of RNA splicing (GO:0033119)4.09627555
21thymic T cell selection (GO:0045061)4.08212987
22NIK/NF-kappaB signaling (GO:0038061)4.00191798
23positive regulation by symbiont of host defense response (GO:0052509)3.93906676
24modulation by symbiont of host defense response (GO:0052031)3.93906676
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.93906676
26modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.93906676
27positive regulation by organism of defense response of other organism involved in symbiotic interact3.93906676
28modulation by symbiont of host immune response (GO:0052553)3.93906676
29histone arginine methylation (GO:0034969)3.93764742
30maturation of SSU-rRNA (GO:0030490)3.86307165
31regulation of vitamin D biosynthetic process (GO:0060556)3.84858989
32macrophage activation involved in immune response (GO:0002281)3.84734498
33ribosomal large subunit biogenesis (GO:0042273)3.84261768
34positive regulation of RNA splicing (GO:0033120)3.73105341
35viral transcription (GO:0019083)3.72904638
36germinal center formation (GO:0002467)3.69954225
37translational termination (GO:0006415)3.63057534
38lipopolysaccharide-mediated signaling pathway (GO:0031663)3.62409705
39neutrophil activation involved in immune response (GO:0002283)3.61135526
40defense response to protozoan (GO:0042832)3.56707382
41response to protozoan (GO:0001562)3.55654387
42DNA deamination (GO:0045006)3.54487302
43regulation of early endosome to late endosome transport (GO:2000641)3.54408776
44DNA replication checkpoint (GO:0000076)3.53304624
45protein localization to kinetochore (GO:0034501)3.50717067
46spliceosomal snRNP assembly (GO:0000387)3.49958893
47positive regulation of gluconeogenesis (GO:0045722)3.47240396
48protein localization to chromosome, centromeric region (GO:0071459)3.44479732
49negative regulation of cell killing (GO:0031342)3.41935858
50negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.41935858
51regulation of interferon-beta biosynthetic process (GO:0045357)3.41467999
52sequestering of actin monomers (GO:0042989)3.41403555
53DNA replication initiation (GO:0006270)3.40966644
54DNA damage response, detection of DNA damage (GO:0042769)3.40516645
55negative regulation of histone methylation (GO:0031061)3.38835713
56regulation of type I interferon-mediated signaling pathway (GO:0060338)3.38095210
57mitotic metaphase plate congression (GO:0007080)3.35826355
58Arp2/3 complex-mediated actin nucleation (GO:0034314)3.35549150
59cellular response to type I interferon (GO:0071357)3.34936678
60type I interferon signaling pathway (GO:0060337)3.34936678
61translational initiation (GO:0006413)3.31055460
62negative regulation of mRNA processing (GO:0050686)3.31015296
63T cell selection (GO:0045058)3.30610033
64regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.30474587
65nucleobase biosynthetic process (GO:0046112)3.29606969
66response to type I interferon (GO:0034340)3.29126674
67ribosomal small subunit assembly (GO:0000028)3.28469844
68translational elongation (GO:0006414)3.28039580
69DNA replication-dependent nucleosome organization (GO:0034723)3.27802621
70DNA replication-dependent nucleosome assembly (GO:0006335)3.27802621
71formation of translation preinitiation complex (GO:0001731)3.27011980
72regulation of T-helper 2 cell differentiation (GO:0045628)3.25968926
73myeloid dendritic cell differentiation (GO:0043011)3.20895717
74DNA strand elongation involved in DNA replication (GO:0006271)3.20383890
75modulation by virus of host process (GO:0019054)3.20079109
76negative regulation of histone acetylation (GO:0035067)3.19373546
77folic acid metabolic process (GO:0046655)3.18268319
78protein complex disassembly (GO:0043241)3.18235688
79regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.17727792
80immunoglobulin mediated immune response (GO:0016064)3.17465919
81GMP metabolic process (GO:0046037)3.17377137
82purine nucleobase biosynthetic process (GO:0009113)3.15533772
83ribonucleoprotein complex biogenesis (GO:0022613)3.14206699
84positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.14114577
85nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.14082259
86ribosomal small subunit biogenesis (GO:0042274)3.13054768
87pre-miRNA processing (GO:0031054)3.10876203
88regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.10055651
89ribosome biogenesis (GO:0042254)3.05612937
90inner cell mass cell proliferation (GO:0001833)3.05550546
91regulation of gamma-delta T cell activation (GO:0046643)3.04322902
92positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.04282748
93interferon-gamma secretion (GO:0072643)3.03734113
94viral life cycle (GO:0019058)3.02246860
95regulation of mast cell degranulation (GO:0043304)3.01200639
96peptidyl-histidine modification (GO:0018202)2.99807062
97DNA unwinding involved in DNA replication (GO:0006268)2.98334229
98regulation of T-helper 1 cell differentiation (GO:0045625)2.97294238
99activation of MAPKKK activity (GO:0000185)2.97136173
100regulation of spindle organization (GO:0090224)2.97104529
101negative regulation of cytokine production involved in immune response (GO:0002719)2.97056543
102DNA strand elongation (GO:0022616)2.97039404
103regulation of chemokine biosynthetic process (GO:0045073)2.95334016
104negative regulation of myeloid cell apoptotic process (GO:0033033)2.94278641
105macromolecular complex disassembly (GO:0032984)2.93536099
106positive regulation of type 2 immune response (GO:0002830)2.93524045
107regulation of vitamin metabolic process (GO:0030656)2.92133767
108detection of other organism (GO:0098543)2.92100782
109positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.91703604
110T-helper 1 type immune response (GO:0042088)2.91690212
111kinetochore assembly (GO:0051382)2.91339128
112cellular protein complex disassembly (GO:0043624)2.90839799
113mannose metabolic process (GO:0006013)2.90458661
114mitotic nuclear envelope disassembly (GO:0007077)2.89223352
115modulation by symbiont of host cellular process (GO:0044068)2.88700331
116negative regulation of erythrocyte differentiation (GO:0045647)2.87535164
117viral mRNA export from host cell nucleus (GO:0046784)2.87401040
118positive regulation of B cell differentiation (GO:0045579)2.86933605
119positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.86143568
120negative regulation of translational initiation (GO:0045947)2.85202883
121lung-associated mesenchyme development (GO:0060484)2.85022860
122detection of bacterium (GO:0016045)2.84963884
123positive regulation of chemokine biosynthetic process (GO:0045080)2.83334552
124regulation of dendritic cell antigen processing and presentation (GO:0002604)2.83331917
125myeloid dendritic cell activation (GO:0001773)2.83026842
126leukocyte aggregation (GO:0070486)2.82313790
127mRNA splicing, via spliceosome (GO:0000398)2.81804031
128RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.81804031
129granulocyte activation (GO:0036230)2.81563594
130rRNA processing (GO:0006364)2.81159571
131protein localization to endosome (GO:0036010)2.79316532
132regulation of leukocyte degranulation (GO:0043300)2.78948654
133positive regulation of T-helper cell differentiation (GO:0045624)2.78413030
134negative regulation of tumor necrosis factor production (GO:0032720)2.78170475
135DNA-dependent DNA replication (GO:0006261)2.77307213
136RNA splicing, via transesterification reactions (GO:0000375)2.76946025
137ribosome assembly (GO:0042255)2.76823036
138specification of organ identity (GO:0010092)2.74138499
139cellular response to thyroid hormone stimulus (GO:0097067)2.72840284
140rRNA metabolic process (GO:0016072)2.71985388
141negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.70530449
142negative regulation of glial cell proliferation (GO:0060253)2.69232690
143regulation of mast cell activation involved in immune response (GO:0033006)2.68879577
144interferon-gamma-mediated signaling pathway (GO:0060333)2.68590104
145regulation of interferon-alpha production (GO:0032647)2.68376165
146regulation of type 2 immune response (GO:0002828)2.68049883
147peptidyl-arginine modification (GO:0018195)2.67789128
148regulation of interleukin-2 biosynthetic process (GO:0045076)2.67414378
149negative regulation of interleukin-2 production (GO:0032703)2.67284061
150regulation of translational termination (GO:0006449)2.67106429
151myeloid cell activation involved in immune response (GO:0002275)2.66662515
152nuclear envelope disassembly (GO:0051081)2.66329907
153membrane disassembly (GO:0030397)2.66329907
154negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.65825426
155regulation of chromatin binding (GO:0035561)2.65661339
156positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.65551607
157T cell migration (GO:0072678)2.62949088
158regulation of myeloid leukocyte mediated immunity (GO:0002886)2.62013017
159regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.61500353
160deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.60651421
161regulation of interleukin-12 production (GO:0032655)2.60089256
162response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.59593226
163response to host immune response (GO:0052572)2.59593226
164positive regulation of interleukin-17 production (GO:0032740)2.58991013
165ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.58959707
166positive regulation of neuroblast proliferation (GO:0002052)2.58931197
167spliceosomal complex assembly (GO:0000245)2.58828818
168telomere maintenance via semi-conservative replication (GO:0032201)2.58302349
169dendritic cell differentiation (GO:0097028)2.56746139
170positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.56495533
171negative regulation of viral release from host cell (GO:1902187)2.55838372
172negative regulation of mRNA metabolic process (GO:1903312)2.55206255
173regulation of tumor necrosis factor production (GO:0032680)2.54670063
174regulation of T-helper cell differentiation (GO:0045622)2.54486612
175neutrophil activation (GO:0042119)2.54481710
176polyamine metabolic process (GO:0006595)2.54155706
177nuclear envelope organization (GO:0006998)2.54019604
178detection of molecule of bacterial origin (GO:0032490)2.53929050
179detection of external biotic stimulus (GO:0098581)2.53409132
180polyamine biosynthetic process (GO:0006596)2.53365913
181negative regulation of peptidyl-lysine acetylation (GO:2000757)2.52785402
182negative regulation of DNA-templated transcription, elongation (GO:0032785)2.52646672
183negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.52646672
184regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.51700454
185actin nucleation (GO:0045010)2.51357370
186antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.50650864
187regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.49998493
188positive regulation of NF-kappaB import into nucleus (GO:0042346)2.49658360
189regulation of podosome assembly (GO:0071801)2.48283938
190negative regulation of innate immune response (GO:0045824)2.46611009
191amino sugar catabolic process (GO:0046348)2.46390361
192cellular extravasation (GO:0045123)2.46335538
193regulation of interleukin-8 biosynthetic process (GO:0045414)2.46189548
194regulation of cytokine secretion involved in immune response (GO:0002739)2.44773983
195antigen processing and presentation of endogenous antigen (GO:0019883)2.43886723
196regulation of B cell receptor signaling pathway (GO:0050855)2.42454606
197macrophage activation (GO:0042116)2.42135496
198regulation of response to interferon-gamma (GO:0060330)2.42126443

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse5.29164770
2E2F7_22180533_ChIP-Seq_HELA_Human4.84942205
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.17748719
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.06570195
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.14445002
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.01363490
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.00793193
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.97092414
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.79515571
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69239228
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.68568329
12MYC_22102868_ChIP-Seq_BL_Human2.57160635
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.51481983
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.45828964
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.45139949
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.44641207
17VDR_21846776_ChIP-Seq_THP-1_Human2.40713189
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.35143287
19XRN2_22483619_ChIP-Seq_HELA_Human2.33029795
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.30122624
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27003974
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.23826116
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.21434350
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20646910
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.14603686
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.14247882
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12949658
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.08969079
29CIITA_25753668_ChIP-Seq_RAJI_Human1.94839071
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.93693647
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.93569234
32* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.91869325
33* RUNX1_22412390_ChIP-Seq_EML_Mouse1.87819709
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87469998
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.86543945
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.86057580
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.85112378
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83911275
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.81927815
40VDR_23849224_ChIP-Seq_CD4+_Human1.81686598
41KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.80358209
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79910441
43* UTX_26944678_Chip-Seq_JUKART_Human1.79898302
44EST1_17652178_ChIP-ChIP_JURKAT_Human1.75383180
45* SPI1_23127762_ChIP-Seq_K562_Human1.74417209
46STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74202578
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.72268237
48ZNF263_19887448_ChIP-Seq_K562_Human1.69857527
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.68655602
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68319100
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.66246454
52DCP1A_22483619_ChIP-Seq_HELA_Human1.66188598
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.65576110
54SCL_19346495_ChIP-Seq_HPC-7_Human1.65224751
55SPI1_23547873_ChIP-Seq_NB4_Human1.64421382
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64379633
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62782746
58* KDM2B_26808549_Chip-Seq_DND41_Human1.59479744
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57437986
60* GABP_19822575_ChIP-Seq_HepG2_Human1.56163390
61GABP_17652178_ChIP-ChIP_JURKAT_Human1.55571567
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.54614657
63NELFA_20434984_ChIP-Seq_ESCs_Mouse1.53946565
64BCL6_27268052_Chip-Seq_Bcells_Human1.52942433
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51942355
66CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49906576
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.48958187
68* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.48637867
69GATA1_26923725_Chip-Seq_HPCs_Mouse1.48543115
70BCOR_27268052_Chip-Seq_Bcells_Human1.48403066
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.46645325
72FOXP3_21729870_ChIP-Seq_TREG_Human1.46148170
73TTF2_22483619_ChIP-Seq_HELA_Human1.45842674
74NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45839918
75RACK7_27058665_Chip-Seq_MCF-7_Human1.45723364
76GATA1_19941827_ChIP-Seq_MEL_Mouse1.45197186
77* ELK3_25401928_ChIP-Seq_HUVEC_Human1.41136089
78NCOR1_26117541_ChIP-Seq_K562_Human1.41063966
79KDM2B_26808549_Chip-Seq_K562_Human1.39768410
80SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.37899536
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36801000
82YY1_22570637_ChIP-Seq_MALME-3M_Human1.36272321
83KDM2B_26808549_Chip-Seq_JURKAT_Human1.35281884
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34842447
85E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34016059
86* SA1_27219007_Chip-Seq_ERYTHROID_Human1.33864367
87PU.1_20513432_ChIP-Seq_Bcells_Mouse1.33403934
88* YY1_21170310_ChIP-Seq_MESCs_Mouse1.32433778
89ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30925117
90TCF7_22412390_ChIP-Seq_EML_Mouse1.30487715
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30440669
92SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30384503
93ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30338229
94POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30191065
95GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29551416
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29187475
97KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27511658
98DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26299382
99* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26175219
100VDR_24763502_ChIP-Seq_THP-1_Human1.25635159
101* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25026560
102LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23705269
103TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22838253
104CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22704825
105TP63_19390658_ChIP-ChIP_HaCaT_Human1.22533703
106HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.21579033
107* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21567530
108KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.20873454
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20753333
110CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20309522
111PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20307994
112NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20238540
113MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19307612
114* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18901330
115IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18815694
116SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18814059
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18254354
118NANOG_21062744_ChIP-ChIP_HESCs_Human1.16890454
119MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15781421
120* MYB_26560356_Chip-Seq_TH2_Human1.15637994
121* SMC4_20622854_ChIP-Seq_HELA_Human1.14795753
122CTCF_26484167_Chip-Seq_Bcells_Mouse1.14290859
123STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13446140
124* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13239428
125HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13215694
126* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12530000
127MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12400358
128EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11637408
129E2F1_21310950_ChIP-Seq_MCF-7_Human1.10691271
130* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10516554
131SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10317310
132KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10312575
133* MAF_26560356_Chip-Seq_TH2_Human1.10189986
134MYB_26560356_Chip-Seq_TH1_Human1.09707355
135* KDM5A_27292631_Chip-Seq_BREAST_Human1.09391284
136NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08068657
137ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07645354
138LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07618537
139GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07138906
140FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07034046
141* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06996991
142AR_21909140_ChIP-Seq_LNCAP_Human1.06946267
143CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05878884
144MAF_26560356_Chip-Seq_TH1_Human1.05693889
145POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05385095
146PHF8_20622854_ChIP-Seq_HELA_Human1.04943992
147GATA1_19941826_ChIP-Seq_K562_Human1.04657934
148STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04067881
149SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03972625
150* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03753577
151TET1_21451524_ChIP-Seq_MESCs_Mouse1.03633154
152ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03270907
153SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02912459
154TFEB_21752829_ChIP-Seq_HELA_Human1.02900189
155NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01272517
156NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00775938
157GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00319453
158CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99558036
159P68_20966046_ChIP-Seq_HELA_Human0.98702967
160CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98646708
161CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98130093
162KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97606536
163LXR_22292898_ChIP-Seq_THP-1_Human0.96126172
164* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94731709
165CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94597356
166ELF1_20517297_ChIP-Seq_JURKAT_Human0.94198530
167* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.93291474
168FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92893371

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation6.14957287
2MP0003646_muscle_fatigue6.04933028
3MP0009278_abnormal_bone_marrow4.37243103
4MP0003111_abnormal_nucleus_morphology4.05852690
5MP0003436_decreased_susceptibility_to3.92893756
6MP0003938_abnormal_ear_development3.82596172
7MP0003693_abnormal_embryo_hatching3.72958916
8MP0005076_abnormal_cell_differentiation3.47528129
9MP0005058_abnormal_lysosome_morphology3.45385235
10MP0003724_increased_susceptibility_to2.96790146
11MP0009785_altered_susceptibility_to2.90528364
12MP0005451_abnormal_body_composition2.71337047
13MP0002148_abnormal_hypersensitivity_rea2.66192550
14MP0003077_abnormal_cell_cycle2.60816635
15MP0002419_abnormal_innate_immunity2.60151208
16MP0004957_abnormal_blastocyst_morpholog2.57306982
17MP0005000_abnormal_immune_tolerance2.52853636
18MP0005025_abnormal_response_to2.50629999
19MP0002653_abnormal_ependyma_morphology2.48151166
20MP0001835_abnormal_antigen_presentation2.44257545
21MP0003172_abnormal_lysosome_physiology2.41201557
22MP0010094_abnormal_chromosome_stability2.38453661
23MP0001790_abnormal_immune_system2.37008557
24MP0005387_immune_system_phenotype2.37008557
25MP0003300_gastrointestinal_ulcer2.33277576
26MP0006082_CNS_inflammation2.33217101
27MP0005397_hematopoietic_system_phenotyp2.27597479
28MP0001545_abnormal_hematopoietic_system2.27597479
29MP0003191_abnormal_cellular_cholesterol2.22191653
30MP0002723_abnormal_immune_serum2.07995524
31MP0005671_abnormal_response_to2.07900865
32MP0004947_skin_inflammation2.04825856
33MP0002452_abnormal_antigen_presenting2.04449217
34MP0001800_abnormal_humoral_immune2.02905299
35MP0008007_abnormal_cellular_replicative1.96675999
36MP0002420_abnormal_adaptive_immunity1.87973746
37MP0001819_abnormal_immune_cell1.87203324
38MP0001533_abnormal_skeleton_physiology1.85169602
39MP0009764_decreased_sensitivity_to1.82590170
40MP0003890_abnormal_embryonic-extraembry1.80512596
41MP0004808_abnormal_hematopoietic_stem1.73980314
42MP0000343_altered_response_to1.71260747
43MP0003315_abnormal_perineum_morphology1.67791249
44MP0000604_amyloidosis1.65232577
45MP0003075_altered_response_to1.64909840
46MP0003656_abnormal_erythrocyte_physiolo1.60346423
47MP0010155_abnormal_intestine_physiology1.55574128
48MP0008932_abnormal_embryonic_tissue1.54747625
49MP0001730_embryonic_growth_arrest1.54742610
50MP0001853_heart_inflammation1.51990839
51MP0009333_abnormal_splenocyte_physiolog1.51889525
52MP0003763_abnormal_thymus_physiology1.51107573
53MP0005464_abnormal_platelet_physiology1.50815319
54MP0001845_abnormal_inflammatory_respons1.49852402
55MP0003718_maternal_effect1.47159018
56MP0000858_altered_metastatic_potential1.46618275
57MP0002234_abnormal_pharynx_morphology1.46609811
58MP0000703_abnormal_thymus_morphology1.45576547
59MP0008469_abnormal_protein_level1.41564726
60MP0000778_abnormal_nervous_system1.38574190
61* MP0000350_abnormal_cell_proliferation1.38234288
62* MP0005380_embryogenesis_phenotype1.37595592
63* MP0001672_abnormal_embryogenesis/_devel1.37595592
64* MP0001697_abnormal_embryo_size1.36746320
65MP0002998_abnormal_bone_remodeling1.34455771
66MP0005310_abnormal_salivary_gland1.32193116
67MP0008004_abnormal_stomach_pH1.31302081
68MP0003690_abnormal_glial_cell1.31239188
69* MP0002085_abnormal_embryonic_tissue1.29461442
70MP0002102_abnormal_ear_morphology1.26483860
71MP0000733_abnormal_muscle_development1.26291694
72MP0005167_abnormal_blood-brain_barrier1.25994461
73MP0003329_amyloid_beta_deposits1.24326928
74MP0003453_abnormal_keratinocyte_physiol1.23569361
75MP0002396_abnormal_hematopoietic_system1.22237557
76MP0002254_reproductive_system_inflammat1.21298955
77MP0004885_abnormal_endolymph1.20714090
78MP0003786_premature_aging1.20599119
79* MP0003984_embryonic_growth_retardation1.19438672
80* MP0002088_abnormal_embryonic_growth/wei1.17536820
81* MP0002080_prenatal_lethality1.15408376
82MP0003567_abnormal_fetal_cardiomyocyte1.15011240
83MP0008995_early_reproductive_senescence1.14166578
84MP0008057_abnormal_DNA_replication1.12635322
85MP0003115_abnormal_respiratory_system1.11356182
86MP0003448_altered_tumor_morphology1.10659623
87MP0000465_gastrointestinal_hemorrhage1.10555582
88* MP0002084_abnormal_developmental_patter1.10529129
89MP0003221_abnormal_cardiomyocyte_apopto1.09545319
90MP0005166_decreased_susceptibility_to1.07894527
91MP0003861_abnormal_nervous_system1.06429301
92MP0009840_abnormal_foam_cell1.03424846
93MP0000490_abnormal_crypts_of1.03057623
94MP0006292_abnormal_olfactory_placode1.02927483
95MP0010307_abnormal_tumor_latency1.01997703
96MP0002697_abnormal_eye_size1.00483655
97MP0002722_abnormal_immune_system1.00117378
98MP0003091_abnormal_cell_migration1.00108728
99* MP0000313_abnormal_cell_death0.98516191
100MP0008260_abnormal_autophagy0.98421281
101MP0000689_abnormal_spleen_morphology0.95866003
102* MP0002086_abnormal_extraembryonic_tissu0.94800220
103MP0002138_abnormal_hepatobiliary_system0.94661218
104MP0003806_abnormal_nucleotide_metabolis0.94037003
105MP0000467_abnormal_esophagus_morphology0.93757823
106MP0005220_abnormal_exocrine_pancreas0.93757474
107MP0001727_abnormal_embryo_implantation0.93374462
108MP0002019_abnormal_tumor_incidence0.93203301
109MP0001286_abnormal_eye_development0.93018908
110MP0002269_muscular_atrophy0.92160831
111MP0000537_abnormal_urethra_morphology0.92143352
112MP0003705_abnormal_hypodermis_morpholog0.91193133
113MP0009763_increased_sensitivity_to0.90188221
114MP0004036_abnormal_muscle_relaxation0.90073003
115MP0003828_pulmonary_edema0.89808789
116MP0003119_abnormal_digestive_system0.88628355
117MP0002398_abnormal_bone_marrow0.88593844
118MP0008874_decreased_physiological_sensi0.88584957
119MP0001663_abnormal_digestive_system0.88131144
120MP0000685_abnormal_immune_system0.86952481
121MP0002877_abnormal_melanocyte_morpholog0.86710919
122MP0002210_abnormal_sex_determination0.86389741
123MP0003183_abnormal_peptide_metabolism0.86093607
124MP0005390_skeleton_phenotype0.84052958
125MP0002332_abnormal_exercise_endurance0.83886365
126MP0002933_joint_inflammation0.83878118
127MP0004130_abnormal_muscle_cell0.83228244
128MP0009765_abnormal_xenobiotic_induced0.82252890
129MP0004133_heterotaxia0.81771247
130MP0004858_abnormal_nervous_system0.81698686
131MP0002405_respiratory_system_inflammati0.81089803
132MP0000749_muscle_degeneration0.79892387
133MP0010030_abnormal_orbit_morphology0.79151947
134MP0004197_abnormal_fetal_growth/weight/0.78638721
135MP0001849_ear_inflammation0.77305728
136MP0000750_abnormal_muscle_regeneration0.74422584
137MP0008058_abnormal_DNA_repair0.74061586
138MP0000920_abnormal_myelination0.73831757
139MP0002163_abnormal_gland_morphology0.73759583
140MP0002139_abnormal_hepatobiliary_system0.73585301
141MP0005381_digestive/alimentary_phenotyp0.73332028
142MP0001145_abnormal_male_reproductive0.72378934
143MP0003795_abnormal_bone_structure0.72001829
144MP0002106_abnormal_muscle_physiology0.71624937
145MP0003123_paternal_imprinting0.71294682
146MP0001851_eye_inflammation0.70821000
147MP0000026_abnormal_inner_ear0.70271233
148MP0003137_abnormal_impulse_conducting0.69876446
149MP0003937_abnormal_limbs/digits/tail_de0.69079446
150MP0002098_abnormal_vibrissa_morphology0.68786727
151MP0003698_abnormal_male_reproductive0.68672179
152MP0001542_abnormal_bone_strength0.67843997
153MP0005621_abnormal_cell_physiology0.67705197
154MP0002429_abnormal_blood_cell0.65710058
155MP0000716_abnormal_immune_system0.65244627
156MP0003195_calcinosis0.64579008
157MP0003935_abnormal_craniofacial_develop0.63799800
158MP0001929_abnormal_gametogenesis0.63551258
159MP0004381_abnormal_hair_follicle0.63427575
160MP0008770_decreased_survivor_rate0.63114743
161MP0004510_myositis0.62371079
162MP0000678_abnormal_parathyroid_gland0.61221413
163MP0005164_abnormal_response_to0.60951899
164MP0000249_abnormal_blood_vessel0.59770483
165MP0003279_aneurysm0.57477534
166MP0000747_muscle_weakness0.55762661
167MP0001873_stomach_inflammation0.55236322
168MP0005535_abnormal_body_temperature0.54834048
169MP0005584_abnormal_enzyme/coenzyme_acti0.53667296
170MP0002132_abnormal_respiratory_system0.51421027

Predicted human phenotypes

RankGene SetZ-score
1Rectal prolapse (HP:0002035)6.24498231
2Abnormality of the fingertips (HP:0001211)6.01714801
3Gastrointestinal infarctions (HP:0005244)5.84127307
4Nasal polyposis (HP:0100582)5.43242252
5Hypochromic anemia (HP:0001931)5.08064482
6Abnormality of glycolipid metabolism (HP:0010969)5.02300753
7Abnormality of liposaccharide metabolism (HP:0010968)5.02300753
8Abnormality of glycosphingolipid metabolism (HP:0004343)5.02300753
9Biliary tract neoplasm (HP:0100574)4.82450639
10Abnormality of nail color (HP:0100643)4.64355284
11Abnormality of the nasal mucosa (HP:0000433)4.49137604
12Eczematoid dermatitis (HP:0000976)4.29478151
13Patellar aplasia (HP:0006443)4.24359275
14Abnormality of macrophages (HP:0004311)4.11418349
15Aplasia/Hypoplasia of the patella (HP:0006498)4.10326680
16Orchitis (HP:0100796)4.07500555
17Myositis (HP:0100614)4.04518998
18Retrobulbar optic neuritis (HP:0100654)3.88301225
19Optic neuritis (HP:0100653)3.88301225
20Esophageal neoplasm (HP:0100751)3.79700304
21Neoplasm of head and neck (HP:0012288)3.79700304
22Breast carcinoma (HP:0003002)3.78568287
23Mediastinal lymphadenopathy (HP:0100721)3.73975329
24Recurrent bacterial skin infections (HP:0005406)3.69652681
25Loss of speech (HP:0002371)3.64655949
26Recurrent abscess formation (HP:0002722)3.56952643
27Abnormality of the intervertebral disk (HP:0005108)3.46232041
28Stomatitis (HP:0010280)3.36079729
29Neoplasm of the pancreas (HP:0002894)3.35417475
30Increased cerebral lipofuscin (HP:0011813)3.31277439
31Dysostosis multiplex (HP:0000943)3.26947888
32Hyperacusis (HP:0010780)3.23273550
33Obstructive lung disease (HP:0006536)3.14593098
34Chronic obstructive pulmonary disease (HP:0006510)3.14593098
35Neoplasm of the rectum (HP:0100743)3.10764663
36Natal tooth (HP:0000695)3.06783996
37Rough bone trabeculation (HP:0100670)3.05008820
38Reticulocytopenia (HP:0001896)3.04088352
39Aplastic anemia (HP:0001915)3.02754224
40Increased IgE level (HP:0003212)2.95170318
41Carpal bone hypoplasia (HP:0001498)2.93373983
42Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.91498216
43Increased serum ferritin (HP:0003281)2.84536740
44Germ cell neoplasia (HP:0100728)2.81588891
45Peripheral hypomyelination (HP:0007182)2.78936292
46Recurrent fungal infections (HP:0002841)2.73441350
47Keratoconjunctivitis sicca (HP:0001097)2.73275918
48Abnormality of polysaccharide metabolism (HP:0011012)2.72064588
49Abnormality of glycosaminoglycan metabolism (HP:0004371)2.72064588
50Abnormality of mucopolysaccharide metabolism (HP:0011020)2.72064588
51Cerebral hypomyelination (HP:0006808)2.68909435
52Vacuolated lymphocytes (HP:0001922)2.66498047
53Recurrent gram-negative bacterial infections (HP:0005420)2.64055717
54Neoplasm of the small intestine (HP:0100833)2.60766202
55Cellulitis (HP:0100658)2.57695626
56Increased neuronal autofluorescent lipopigment (HP:0002074)2.56844661
57Elevated erythrocyte sedimentation rate (HP:0003565)2.55458398
58Interstitial pulmonary disease (HP:0006530)2.54094461
59Systemic lupus erythematosus (HP:0002725)2.53172043
60Breast hypoplasia (HP:0003187)2.51720423
61Testicular neoplasm (HP:0010788)2.51698749
62Capillary hemangiomas (HP:0005306)2.50152807
63Axonal loss (HP:0003447)2.48089030
64Mutism (HP:0002300)2.46947220
65Neuronal loss in central nervous system (HP:0002529)2.46399762
66Abnormality of cells of the erythroid lineage (HP:0012130)2.45884231
67Ependymoma (HP:0002888)2.41736217
68Abnormal gallbladder physiology (HP:0012438)2.41455831
69Cholecystitis (HP:0001082)2.41455831
70Mucopolysacchariduria (HP:0008155)2.39695732
71Urinary glycosaminoglycan excretion (HP:0003541)2.39695732
72Tapered finger (HP:0001182)2.39626578
73Overriding aorta (HP:0002623)2.39121075
74Recurrent viral infections (HP:0004429)2.37960275
75Autoimmune thrombocytopenia (HP:0001973)2.37579465
76Keratoconjunctivitis (HP:0001096)2.37113447
77Abnormal number of incisors (HP:0011064)2.36953102
78Amyloidosis (HP:0011034)2.36698027
79Gonadal dysgenesis (HP:0000133)2.34785531
80Petechiae (HP:0000967)2.33581410
81Premature ovarian failure (HP:0008209)2.33444733
82Diminished motivation (HP:0000745)2.32111143
83Spina bifida occulta (HP:0003298)2.31948353
84Gingivitis (HP:0000230)2.31429957
85Abnormal biliary tract morphology (HP:0012440)2.29798266
86Meningitis (HP:0001287)2.29304079
87Recurrent skin infections (HP:0001581)2.26583202
88Colitis (HP:0002583)2.26427143
89Slow-growing hair (HP:0002217)2.26056873
90Abnormality of hair growth rate (HP:0011363)2.26056873
91Gastrointestinal carcinoma (HP:0002672)2.25932025
92Malignant gastrointestinal tract tumors (HP:0006749)2.25932025
93Apathy (HP:0000741)2.25020539
94Polycythemia (HP:0001901)2.23273434
95Vasculitis (HP:0002633)2.23035124
96Progressive muscle weakness (HP:0003323)2.22888046
97Renal duplication (HP:0000075)2.22223128
98Neurofibrillary tangles (HP:0002185)2.21924496
99Supranuclear gaze palsy (HP:0000605)2.21535234
100Pulmonary infiltrates (HP:0002113)2.20929835
101J-shaped sella turcica (HP:0002680)2.17615226
102Abnormality of iron homeostasis (HP:0011031)2.17491413
103Deep palmar crease (HP:0006191)2.17176629
104Disinhibition (HP:0000734)2.15565036
105Hepatosplenomegaly (HP:0001433)2.15345577
106Thoracic kyphosis (HP:0002942)2.15154989
107Upper motor neuron abnormality (HP:0002127)2.15125564
108Acne (HP:0001061)2.14384707
109Thin bony cortex (HP:0002753)2.13644011
110Abnormal number of erythroid precursors (HP:0012131)2.12890524
111Nuclear cataract (HP:0100018)2.12883637
112Elfin facies (HP:0004428)2.12818133
113Precocious puberty (HP:0000826)2.11753299
114Chromosomal breakage induced by crosslinking agents (HP:0003221)2.11417127
115Recurrent cutaneous fungal infections (HP:0011370)2.09629386
116Chronic mucocutaneous candidiasis (HP:0002728)2.09629386
117Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.08562850
118Anal stenosis (HP:0002025)2.07233057
119Aplasia/Hypoplasia of the uvula (HP:0010293)2.06750674
120Increased IgM level (HP:0003496)2.05091837
121Overlapping toe (HP:0001845)2.04919557
122Hemoptysis (HP:0002105)2.04728209
123Myopathic facies (HP:0002058)2.04278179
124Abnormal trabecular bone morphology (HP:0100671)2.02505568
125Horseshoe kidney (HP:0000085)2.02470560
126Encephalitis (HP:0002383)2.01033561
127Progressive neurologic deterioration (HP:0002344)2.00621935
128Macrocytic anemia (HP:0001972)1.99401605
129Episodic fever (HP:0001954)1.99081585
130Myocardial infarction (HP:0001658)1.97698028
131Impulsivity (HP:0100710)1.97495126
132Hemangiomatosis (HP:0007461)1.96617955
133Areflexia of lower limbs (HP:0002522)1.96141717
134Nemaline bodies (HP:0003798)1.96105985
135Purpura (HP:0000979)1.96049222
136Hypergammaglobulinemia (HP:0010702)1.95835419
137Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.94876064
138Insomnia (HP:0100785)1.93618176
139Distal lower limb amyotrophy (HP:0008944)1.93178058
140Oral leukoplakia (HP:0002745)1.92713208
141Pancreatic cysts (HP:0001737)1.92326711
142Gastrointestinal inflammation (HP:0004386)1.91552570
143Short chin (HP:0000331)1.90679085
144Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.86543665
145Cerebral inclusion bodies (HP:0100314)1.86458154
146Prolonged neonatal jaundice (HP:0006579)1.86084354
147Prolonged bleeding time (HP:0003010)1.85342875
148Uterine neoplasm (HP:0010784)1.85143216
149Slow saccadic eye movements (HP:0000514)1.85072233
150Neoplasm of the colon (HP:0100273)1.84431054
151Tracheoesophageal fistula (HP:0002575)1.83286993
152Premature loss of primary teeth (HP:0006323)1.83152149
153Leukocytosis (HP:0001974)1.82673727
154Granulocytopenia (HP:0001913)1.81949093
155Abnormality of the peritoneum (HP:0002585)1.80203487
156Arterial thrombosis (HP:0004420)1.79867188
157Muscle fiber inclusion bodies (HP:0100299)1.79307245
158Pustule (HP:0200039)1.78761914
159Urticaria (HP:0001025)1.78353379
160Meckel diverticulum (HP:0002245)1.77646887
161Inflammation of the large intestine (HP:0002037)1.77471988
162Cleft eyelid (HP:0000625)1.76530460
163Ankle clonus (HP:0011448)1.76414220
164Renovascular hypertension (HP:0100817)1.76153881
165Abnormal delayed hypersensitivity skin test (HP:0002963)1.75971987
166Glomerulopathy (HP:0100820)1.75800946
167Asymmetric septal hypertrophy (HP:0001670)1.75594943
168Trismus (HP:0000211)1.74691000
169Ragged-red muscle fibers (HP:0003200)1.74379226
170Elevated alkaline phosphatase (HP:0003155)1.73200677
171Pallor (HP:0000980)1.72870614
172Difficulty climbing stairs (HP:0003551)1.72338856
173Oligodactyly (HP:0012165)1.71753175
174Progressive microcephaly (HP:0000253)1.71334566
175Sparse lateral eyebrow (HP:0005338)1.70988384
176Ventricular fibrillation (HP:0001663)1.70811313
177Pelvic girdle muscle weakness (HP:0003749)1.69981514
178Shoulder girdle muscle weakness (HP:0003547)1.68761150
179Selective tooth agenesis (HP:0001592)1.68237005
180Abnormality of the preputium (HP:0100587)1.67723922
181Anonychia (HP:0001798)1.67651120
182Abnormality of the ileum (HP:0001549)1.67118301
183Testicular atrophy (HP:0000029)1.66467453
184Ventricular tachycardia (HP:0004756)1.66312007
185Personality changes (HP:0000751)1.65643043
186Long palpebral fissure (HP:0000637)1.64980471
187Small epiphyses (HP:0010585)1.64324065
188Birth length less than 3rd percentile (HP:0003561)1.64268581
189Embryonal neoplasm (HP:0002898)1.63491797
190Abnormality of the labia minora (HP:0012880)1.62773018
191Hypertensive crisis (HP:0100735)1.62245959
192Muscle fiber splitting (HP:0003555)1.62234732
193Myokymia (HP:0002411)1.61855584
194Absent radius (HP:0003974)1.61247472
195Prominent nose (HP:0000448)1.60627743

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.19062812
2NME24.11781847
3TAOK24.06906564
4BUB13.85903209
5IRAK33.33567062
6MAP3K123.04359684
7ERN12.87038583
8MAP2K32.79131250
9WEE12.47048433
10RIPK42.41995320
11TBK12.35833829
12MAP3K142.31753660
13SRPK12.29214727
14PAK42.14067937
15CCNB12.10873544
16NEK22.09029638
17DAPK31.99970542
18TYK21.99251594
19IRAK41.94014647
20RPS6KA21.92190820
21BLK1.91891624
22ACVR1B1.82954725
23LIMK11.81447882
24DYRK31.76913063
25MATK1.72559188
26MKNK21.65733374
27MAP3K81.58871929
28MAP3K101.58167506
29MAP3K131.57404848
30KSR11.56716148
31MAP3K111.55409990
32ICK1.52756560
33EPHB11.50913631
34RIPK11.49947985
35RPS6KL11.48209665
36RPS6KC11.48209665
37MAP3K31.48116433
38ZAP701.44969056
39DDR21.42112964
40PIM21.41966093
41TESK21.41229155
42TTK1.40903052
43FES1.39603578
44MAP3K61.36327654
45CSK1.35276329
46IKBKE1.33979283
47STK161.33553364
48RPS6KA61.31677769
49JAK31.29578880
50GRK71.28628949
51RPS6KA51.28140027
52EIF2AK11.27863266
53STK111.27623342
54EEF2K1.27103849
55DAPK11.26825377
56MKNK11.24842377
57SIK11.22606962
58PDK31.21862496
59PDK41.21862496
60EPHA31.19939034
61FGR1.16160923
62ALK1.15313786
63TNK21.12683363
64FGFR41.11986833
65EPHA21.11741582
66TESK11.11427073
67MARK21.10396336
68MOS1.09259798
69SIK21.08961242
70TRIB31.07925964
71PRKD21.07515948
72MAP3K11.07068862
73MAP4K11.06943116
74AURKA1.06785660
75PLK11.03639829
76AURKB1.00022729
77IRAK20.99878016
78MYLK0.98043917
79CDK190.97241221
80CDK70.95723599
81EPHB20.95363722
82SIK30.91929711
83MAP2K20.90758280
84CHEK20.90640779
85BTK0.88838909
86TYRO30.88057798
87STK100.86981889
88HCK0.85675154
89PAK10.85487995
90SYK0.83256674
91CDK120.82940177
92BRAF0.82520540
93SMG10.80725415
94JAK20.79387233
95PRPF4B0.78489849
96TSSK60.77823201
97TGFBR10.75796595
98BRSK10.74048979
99LYN0.73996810
100TXK0.72833456
101CLK10.72444543
102JAK10.70791781
103LCK0.70446027
104CSF1R0.69431352
105STK40.68927038
106IRAK10.68608733
107DAPK20.68371540
108TTN0.68121987
109PINK10.67655959
110DYRK1B0.67407500
111RPS6KA10.67035612
112PKN20.66249348
113ARAF0.63643988
114TAOK10.59817715
115PLK30.58620714
116MAP3K50.57611710
117BRSK20.57200008
118IKBKB0.56864058
119ABL20.55482708
120PRKD30.54746142
121CHEK10.54655393
122MAPK70.51471287
123CDC42BPA0.50948228
124BMX0.50585585
125MAP3K70.50322596
126ILK0.50290845
127PDPK10.49112914
128PDK10.49055215
129MAPK120.48317934
130KDR0.47181719
131PAK60.46679524
132TAOK30.45513564
133NTRK20.45332644
134DYRK20.44642107
135BCKDK0.44459338
136MAPK40.44016934
137NEK10.43989938
138CDK20.43980982
139MARK30.43507204
140KIT0.43221462
141PAK20.42056171
142CDK40.41706126
143ATR0.41702434
144PTK60.41664682
145PIM10.41640149
146PRKCZ0.41587620
147MAPK110.41298928
148MAP2K60.40910045
149CDK90.40576291
150BMPR20.38778351
151STK30.37994032
152MAPKAPK20.37649619
153HIPK20.37083107
154BRD40.36079371
155CDC70.35745872
156MAP2K40.35506738
157MST1R0.34930760
158CAMK1D0.34624888
159PRKD10.34546012
160MELK0.34347888
161MTOR0.33009477
162TGFBR20.32870698
163RPS6KB20.32854890
164CHUK0.32846388
165CAMK1G0.32174007
166ERBB20.31169976
167CSNK1G30.30809372
168GRK60.30603766

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.58908687
2DNA replication_Homo sapiens_hsa030303.51560558
3Other glycan degradation_Homo sapiens_hsa005113.26274480
4Ribosome_Homo sapiens_hsa030103.24397186
5Spliceosome_Homo sapiens_hsa030403.15144895
6Base excision repair_Homo sapiens_hsa034102.72329700
7Osteoclast differentiation_Homo sapiens_hsa043802.71804345
8RNA transport_Homo sapiens_hsa030132.71685418
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.62864312
10Notch signaling pathway_Homo sapiens_hsa043302.60468664
11RNA polymerase_Homo sapiens_hsa030202.58730824
12Vitamin B6 metabolism_Homo sapiens_hsa007502.55019595
13* Cell cycle_Homo sapiens_hsa041102.45469347
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.30619585
15Leishmaniasis_Homo sapiens_hsa051402.29491310
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.08139785
17NOD-like receptor signaling pathway_Homo sapiens_hsa046212.06486956
18TNF signaling pathway_Homo sapiens_hsa046682.01127976
19Lysosome_Homo sapiens_hsa041422.00174424
20Mismatch repair_Homo sapiens_hsa034301.94273405
21Tuberculosis_Homo sapiens_hsa051521.91189699
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.86948526
23Malaria_Homo sapiens_hsa051441.86819986
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.80806225
25Proteasome_Homo sapiens_hsa030501.80442866
26Salmonella infection_Homo sapiens_hsa051321.79482624
27Chronic myeloid leukemia_Homo sapiens_hsa052201.77731185
28Pertussis_Homo sapiens_hsa051331.76874802
29Nucleotide excision repair_Homo sapiens_hsa034201.74381020
30Rheumatoid arthritis_Homo sapiens_hsa053231.72480719
31Sulfur relay system_Homo sapiens_hsa041221.71205298
32mRNA surveillance pathway_Homo sapiens_hsa030151.67935057
33Pyrimidine metabolism_Homo sapiens_hsa002401.65791827
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.60982915
35Shigellosis_Homo sapiens_hsa051311.59210993
36Allograft rejection_Homo sapiens_hsa053301.56778314
37Epstein-Barr virus infection_Homo sapiens_hsa051691.55123201
38Staphylococcus aureus infection_Homo sapiens_hsa051501.53179209
39Legionellosis_Homo sapiens_hsa051341.53146249
40Hedgehog signaling pathway_Homo sapiens_hsa043401.51963519
41p53 signaling pathway_Homo sapiens_hsa041151.51645376
42Toxoplasmosis_Homo sapiens_hsa051451.49617217
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.48198501
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46736105
45Basal cell carcinoma_Homo sapiens_hsa052171.45187589
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.41103487
47Phagosome_Homo sapiens_hsa041451.33264262
48Graft-versus-host disease_Homo sapiens_hsa053321.27522340
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.27471364
50Renal cell carcinoma_Homo sapiens_hsa052111.25630911
51Fanconi anemia pathway_Homo sapiens_hsa034601.20603882
52Basal transcription factors_Homo sapiens_hsa030221.19205626
53HTLV-I infection_Homo sapiens_hsa051661.18413372
54Primary immunodeficiency_Homo sapiens_hsa053401.18186949
55Chemokine signaling pathway_Homo sapiens_hsa040621.12926550
56Homologous recombination_Homo sapiens_hsa034401.12925660
57Autoimmune thyroid disease_Homo sapiens_hsa053201.10903396
58African trypanosomiasis_Homo sapiens_hsa051431.09758089
59Oocyte meiosis_Homo sapiens_hsa041141.07014504
60Herpes simplex infection_Homo sapiens_hsa051681.05891280
61Small cell lung cancer_Homo sapiens_hsa052221.05678088
62MicroRNAs in cancer_Homo sapiens_hsa052061.04396059
63Hematopoietic cell lineage_Homo sapiens_hsa046401.02370596
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98983914
65Asthma_Homo sapiens_hsa053100.97413701
66Ether lipid metabolism_Homo sapiens_hsa005650.97409100
67Type I diabetes mellitus_Homo sapiens_hsa049400.96538985
68FoxO signaling pathway_Homo sapiens_hsa040680.96455860
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.91694146
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91400870
71Thyroid cancer_Homo sapiens_hsa052160.90505657
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.90370695
73HIF-1 signaling pathway_Homo sapiens_hsa040660.90145439
74T cell receptor signaling pathway_Homo sapiens_hsa046600.89670007
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88405377
76Fructose and mannose metabolism_Homo sapiens_hsa000510.88012765
77Folate biosynthesis_Homo sapiens_hsa007900.87971422
78Non-small cell lung cancer_Homo sapiens_hsa052230.87556571
79mTOR signaling pathway_Homo sapiens_hsa041500.86133771
80Vibrio cholerae infection_Homo sapiens_hsa051100.85376997
81B cell receptor signaling pathway_Homo sapiens_hsa046620.82784881
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80833858
83Purine metabolism_Homo sapiens_hsa002300.80704612
84Viral carcinogenesis_Homo sapiens_hsa052030.79898896
85Hippo signaling pathway_Homo sapiens_hsa043900.79650404
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.79589287
87Bladder cancer_Homo sapiens_hsa052190.79071643
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.78824138
89Prion diseases_Homo sapiens_hsa050200.78314209
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.77332446
91Pathways in cancer_Homo sapiens_hsa052000.76733116
92Regulation of autophagy_Homo sapiens_hsa041400.76258609
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75899330
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73567109
95Non-homologous end-joining_Homo sapiens_hsa034500.72480534
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71819523
97Apoptosis_Homo sapiens_hsa042100.70919806
98Amoebiasis_Homo sapiens_hsa051460.69586855
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69522547
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68657740
101Acute myeloid leukemia_Homo sapiens_hsa052210.68169489
102Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65780166
103Measles_Homo sapiens_hsa051620.65509880
104Collecting duct acid secretion_Homo sapiens_hsa049660.65278713
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.64852619
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64589047
107Synaptic vesicle cycle_Homo sapiens_hsa047210.64459612
108One carbon pool by folate_Homo sapiens_hsa006700.62861291
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62205124
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59874535
111Galactose metabolism_Homo sapiens_hsa000520.59762639
112Viral myocarditis_Homo sapiens_hsa054160.58781197
113Wnt signaling pathway_Homo sapiens_hsa043100.58491900
114Endocytosis_Homo sapiens_hsa041440.58429791
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57714512
116Pentose phosphate pathway_Homo sapiens_hsa000300.56980094
117Systemic lupus erythematosus_Homo sapiens_hsa053220.56704945
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56496541
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.56406965
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.55817220
121Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53339165
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53031792
123* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52811121
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.52626150
125Tight junction_Homo sapiens_hsa045300.52386606
126Type II diabetes mellitus_Homo sapiens_hsa049300.51684164
127Inositol phosphate metabolism_Homo sapiens_hsa005620.51344907
128Antigen processing and presentation_Homo sapiens_hsa046120.51161769
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50700182
130Circadian rhythm_Homo sapiens_hsa047100.50576148
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50215256
132Influenza A_Homo sapiens_hsa051640.49852847
133Glioma_Homo sapiens_hsa052140.49481980
134Hepatitis B_Homo sapiens_hsa051610.49031864
135Colorectal cancer_Homo sapiens_hsa052100.48830295
136Cardiac muscle contraction_Homo sapiens_hsa042600.48467419
137Platelet activation_Homo sapiens_hsa046110.48095422
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47598033
139VEGF signaling pathway_Homo sapiens_hsa043700.47560514
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.47217534
141Parkinsons disease_Homo sapiens_hsa050120.46499045
142Insulin signaling pathway_Homo sapiens_hsa049100.45411867
143Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45090283
144Alcoholism_Homo sapiens_hsa050340.44771404
145Prolactin signaling pathway_Homo sapiens_hsa049170.43963219
146MAPK signaling pathway_Homo sapiens_hsa040100.43333644
147Insulin resistance_Homo sapiens_hsa049310.42831110
148Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42353632
149ErbB signaling pathway_Homo sapiens_hsa040120.41986317
150Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41761387
151Neurotrophin signaling pathway_Homo sapiens_hsa047220.39398995
152Jak-STAT signaling pathway_Homo sapiens_hsa046300.39156180
153Endometrial cancer_Homo sapiens_hsa052130.39128342
154AMPK signaling pathway_Homo sapiens_hsa041520.39113602
155Huntingtons disease_Homo sapiens_hsa050160.38720345
156Pancreatic cancer_Homo sapiens_hsa052120.38708446
157GnRH signaling pathway_Homo sapiens_hsa049120.38642938
158Hepatitis C_Homo sapiens_hsa051600.37838082

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