ZBTB16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1carnitine shuttle (GO:0006853)4.80790261
2fatty acid transmembrane transport (GO:1902001)4.72994507
3regulation of sequestering of triglyceride (GO:0010889)4.49570349
4positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.24102884
5positive regulation of fatty acid oxidation (GO:0046321)3.85059571
6sarcomere organization (GO:0045214)3.78945949
7positive regulation of fatty acid beta-oxidation (GO:0032000)3.74272187
8regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.69991487
9cardiac myofibril assembly (GO:0055003)3.69491743
10response to inactivity (GO:0014854)3.65869438
11regulation of fatty acid oxidation (GO:0046320)3.64814526
12carnitine transmembrane transport (GO:1902603)3.60398990
13regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.59592368
14regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.59163212
15regulation of acyl-CoA biosynthetic process (GO:0050812)3.53142376
16tricarboxylic acid cycle (GO:0006099)3.51217887
17succinate metabolic process (GO:0006105)3.49027895
18myofibril assembly (GO:0030239)3.47169731
19interkinetic nuclear migration (GO:0022027)3.42216477
20regulation of skeletal muscle contraction (GO:0014819)3.41176195
21regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.39626466
222-oxoglutarate metabolic process (GO:0006103)3.39417499
23tachykinin receptor signaling pathway (GO:0007217)3.37883295
24biotin metabolic process (GO:0006768)3.37343284
25fatty acid beta-oxidation (GO:0006635)3.34669981
26behavioral response to nicotine (GO:0035095)3.34442334
27amino-acid betaine transport (GO:0015838)3.31971635
28carnitine transport (GO:0015879)3.31971635
29negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.30625508
30sarcoplasmic reticulum calcium ion transport (GO:0070296)3.30427318
31NADH metabolic process (GO:0006734)3.29968339
32actin-myosin filament sliding (GO:0033275)3.24925656
33muscle filament sliding (GO:0030049)3.24925656
34acetyl-CoA metabolic process (GO:0006084)3.24793936
35regulation of cell communication by electrical coupling (GO:0010649)3.22294704
36regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.19188856
37regulation of fatty acid beta-oxidation (GO:0031998)3.17608255
38oxaloacetate metabolic process (GO:0006107)3.16137193
39regulation of relaxation of muscle (GO:1901077)3.12345339
40cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.09944148
41cardiac muscle contraction (GO:0060048)3.09200203
42regulation of cofactor metabolic process (GO:0051193)3.09184504
43regulation of coenzyme metabolic process (GO:0051196)3.09184504
44plasma membrane repair (GO:0001778)3.08415008
45fatty acid catabolic process (GO:0009062)3.00696458
46triglyceride catabolic process (GO:0019433)2.99431275
47cellular response to epinephrine stimulus (GO:0071872)2.98853086
48fatty acid oxidation (GO:0019395)2.98763737
49skeletal muscle contraction (GO:0003009)2.97302961
50myotube cell development (GO:0014904)2.97053189
51regulation of actin filament-based movement (GO:1903115)2.95599471
52low-density lipoprotein particle clearance (GO:0034383)2.95293710
53cardiac muscle hypertrophy (GO:0003300)2.95211447
54fatty acid homeostasis (GO:0055089)2.95177376
55neutral lipid catabolic process (GO:0046461)2.94677655
56acylglycerol catabolic process (GO:0046464)2.94677655
57response to epinephrine (GO:0071871)2.93450704
58lipid oxidation (GO:0034440)2.92674925
59striated muscle hypertrophy (GO:0014897)2.92653634
60membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.91615678
61adrenergic receptor signaling pathway (GO:0071875)2.89988908
62lysine catabolic process (GO:0006554)2.89057711
63lysine metabolic process (GO:0006553)2.89057711
64negative regulation of potassium ion transmembrane transport (GO:1901380)2.88624478
65vocalization behavior (GO:0071625)2.88299248
66muscle contraction (GO:0006936)2.86390970
67ventricular cardiac muscle cell action potential (GO:0086005)2.82828165
68brown fat cell differentiation (GO:0050873)2.82561087
69actin filament-based movement (GO:0030048)2.82397207
70striated muscle contraction (GO:0006941)2.74700818
71negative regulation of cytosolic calcium ion concentration (GO:0051481)2.74210224
72muscle hypertrophy (GO:0014896)2.74173583
73exogenous drug catabolic process (GO:0042738)2.73834869
74positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.73575606
75skeletal muscle adaptation (GO:0043501)2.73315988
76aspartate family amino acid catabolic process (GO:0009068)2.73285835
77detection of calcium ion (GO:0005513)2.72615880
78cell communication involved in cardiac conduction (GO:0086065)2.72396353
79actin-mediated cell contraction (GO:0070252)2.71811814
80regulation of triglyceride catabolic process (GO:0010896)2.71599544
81complement activation, alternative pathway (GO:0006957)2.71497347
82adult heart development (GO:0007512)2.70662798
83urinary tract smooth muscle contraction (GO:0014848)2.70587847
84glycogen catabolic process (GO:0005980)2.70465336
85drug catabolic process (GO:0042737)2.70285132
86valine metabolic process (GO:0006573)2.70127373
87alpha-linolenic acid metabolic process (GO:0036109)2.69323839
88positive regulation of cation channel activity (GO:2001259)2.68294462
89muscle system process (GO:0003012)2.67967051
90response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.66949317
91phospholipid homeostasis (GO:0055091)2.66326997
92positive regulation of lipid catabolic process (GO:0050996)2.64940138
93positive regulation of glycogen metabolic process (GO:0070875)2.64875695
94regulation of striated muscle contraction (GO:0006942)2.63058062
95creatine metabolic process (GO:0006600)2.61534628
96somite development (GO:0061053)2.60956004
97regulation of sulfur metabolic process (GO:0042762)2.60867875
98cell communication by electrical coupling (GO:0010644)2.60768130
99membrane depolarization during action potential (GO:0086010)2.60167187
100thioester biosynthetic process (GO:0035384)2.59373845
101acyl-CoA biosynthetic process (GO:0071616)2.59373845
102regulation of calcium ion transmembrane transport (GO:1903169)2.58807474
103regulation of calcium ion transmembrane transporter activity (GO:1901019)2.58807474
104neuromuscular synaptic transmission (GO:0007274)2.57766053
105neurotransmitter catabolic process (GO:0042135)2.57661022
106actomyosin structure organization (GO:0031032)2.57422837
107glucan catabolic process (GO:0009251)2.57410007
108regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.57280397
109monocarboxylic acid catabolic process (GO:0072329)2.56690986
110branched-chain amino acid catabolic process (GO:0009083)2.56337300
111bundle of His cell to Purkinje myocyte communication (GO:0086069)2.56144068
112muscle fiber development (GO:0048747)2.54667252
113short-chain fatty acid metabolic process (GO:0046459)2.54508967
114skeletal muscle fiber development (GO:0048741)2.54384287
115dicarboxylic acid catabolic process (GO:0043649)2.53135766
116lipid particle organization (GO:0034389)2.53020729
117regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.52717800
118quaternary ammonium group transport (GO:0015697)2.52539512
119regulation of membrane repolarization (GO:0060306)2.52489305
120positive regulation of digestive system process (GO:0060456)2.51034578
121intracellular lipid transport (GO:0032365)2.50174936
122regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.47647038
123fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.46096360
124neuronal action potential propagation (GO:0019227)2.45652510
125positive regulation of glycogen biosynthetic process (GO:0045725)2.45650900
126regulation of p38MAPK cascade (GO:1900744)2.43407342
127branched-chain amino acid metabolic process (GO:0009081)2.42203751
128positive regulation of myoblast differentiation (GO:0045663)2.42079456
129definitive hemopoiesis (GO:0060216)2.40503447
130pyrimidine nucleobase catabolic process (GO:0006208)2.38149393
131negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.36974038
132positive regulation of T cell differentiation in thymus (GO:0033089)2.34596728
133regulation of female receptivity (GO:0045924)2.33817638
134growth hormone receptor signaling pathway (GO:0060396)2.33263230
135arginine catabolic process (GO:0006527)2.32158025
136negative regulation of protein localization to cell surface (GO:2000009)2.32006346
137response to cold (GO:0009409)2.31358848
138relaxation of muscle (GO:0090075)2.30819380
139positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.30557202
140striated muscle adaptation (GO:0014888)2.29718190
141regulation of action potential (GO:0098900)2.27737476
142negative regulation of calcium ion transmembrane transport (GO:1903170)2.27368148
143negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.27368148
144regulation of endothelial cell differentiation (GO:0045601)2.26528312
145adenosine metabolic process (GO:0046085)2.26492086
146relaxation of cardiac muscle (GO:0055119)2.23883387
147nucleus localization (GO:0051647)2.23251691
148cellular response to growth hormone stimulus (GO:0071378)2.22796117
149regulation of sodium ion transmembrane transporter activity (GO:2000649)2.22734727
150cGMP-mediated signaling (GO:0019934)2.18490453
151regulation of germinal center formation (GO:0002634)2.17749877
152glyoxylate metabolic process (GO:0046487)2.16505593
153oxidative demethylation (GO:0070989)2.16105953
154cAMP catabolic process (GO:0006198)2.15670277
155regulation of sarcomere organization (GO:0060297)2.13079099

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.52193407
2* EZH2_22144423_ChIP-Seq_EOC_Human3.40938989
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.89438729
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.75969953
5GBX2_23144817_ChIP-Seq_PC3_Human2.74456511
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.25264500
7* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.20744748
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.18041488
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.14012425
10* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.13371644
11IGF1R_20145208_ChIP-Seq_DFB_Human2.09995180
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07054694
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.05547750
14EP300_21415370_ChIP-Seq_HL-1_Mouse2.00631335
15* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.00048299
16* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92095464
17* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92095464
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91536029
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87314838
20* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.82973053
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81952907
22* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.79975669
23DROSHA_22980978_ChIP-Seq_HELA_Human1.77869513
24* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.77501949
25VDR_22108803_ChIP-Seq_LS180_Human1.72570695
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70272696
27SCL_19346495_ChIP-Seq_HPC-7_Human1.67449878
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67392423
29PPARA_22158963_ChIP-Seq_LIVER_Mouse1.67224001
30* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.65046786
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.64250013
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.63599307
33* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.58184117
34ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.55963709
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.54308164
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.52797145
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.48484990
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47173335
39AR_21572438_ChIP-Seq_LNCaP_Human1.45059011
40SMAD4_21799915_ChIP-Seq_A2780_Human1.43793243
41ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.43769383
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.41377576
43TAF15_26573619_Chip-Seq_HEK293_Human1.40147840
44* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39038272
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.38975526
46* EZH2_27294783_Chip-Seq_ESCs_Mouse1.38968783
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38955801
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.37039416
49GATA1_22025678_ChIP-Seq_K562_Human1.36918967
50* TBX20_22080862_ChIP-Seq_HEART_Mouse1.36736254
51* TBX20_22328084_ChIP-Seq_HEART_Mouse1.36736254
52* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32393644
53STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.30984981
54AHR_22903824_ChIP-Seq_MCF-7_Human1.30786535
55* RUNX_20019798_ChIP-Seq_JUKART_Human1.29399608
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29016547
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.27715214
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27122647
59* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25447426
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24595123
61* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23548265
62ZNF263_19887448_ChIP-Seq_K562_Human1.23452343
63BCAT_22108803_ChIP-Seq_LS180_Human1.22347861
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.22206156
65CLOCK_20551151_ChIP-Seq_293T_Human1.22190202
66RARB_27405468_Chip-Seq_BRAIN_Mouse1.21461541
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20721413
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.17651024
69FOXA2_19822575_ChIP-Seq_HepG2_Human1.16819213
70TP53_16413492_ChIP-PET_HCT116_Human1.14810706
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14333894
72CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12210759
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10925215
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10877083
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10444457
76PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10028077
77AR_25329375_ChIP-Seq_VCAP_Human1.09641975
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09343383
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09050926
80* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08802360
81PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07092269
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.05225187
83* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04240863
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04195544
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04195544
86WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03723652
87REST_21632747_ChIP-Seq_MESCs_Mouse1.02683814
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02134321
89TCF4_18268006_ChIP-ChIP_LS174T_Human1.01725704
90STAT3_23295773_ChIP-Seq_U87_Human1.00338012
91TCF4_23295773_ChIP-Seq_U87_Human0.99352409
92* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99304515
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99080841
94NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98720400
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98720400
96* AR_19668381_ChIP-Seq_PC3_Human0.98163228
97ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97702049
98FLI1_27457419_Chip-Seq_LIVER_Mouse0.96847039
99* SMAD4_21741376_ChIP-Seq_HESCs_Human0.96542153
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96321103
101PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95307751
102P300_19829295_ChIP-Seq_ESCs_Human0.95082234
103STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94877756
104EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94627756
105TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94425568
106PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94409181
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93949941
108CBP_20019798_ChIP-Seq_JUKART_Human0.93949941
109* SMAD3_21741376_ChIP-Seq_HESCs_Human0.93228163
110POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93159079
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92954491
112GATA2_21666600_ChIP-Seq_HMVEC_Human0.92548809
113CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.92217492
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90342316
115CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89805234
116* REST_18959480_ChIP-ChIP_MESCs_Mouse0.89805086
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89331103
118RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89310321
119ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88977659
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88927006
121RXR_22108803_ChIP-Seq_LS180_Human0.88857390
122TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88288013
123TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87225880
124* RUNX2_22187159_ChIP-Seq_PCA_Human0.86570560
125ER_23166858_ChIP-Seq_MCF-7_Human0.86351177
126* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86315788
127PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.85598870
128* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85592650
129ZNF274_21170338_ChIP-Seq_K562_Hela0.85397524
130PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84947674
131CBX2_27304074_Chip-Seq_ESCs_Mouse0.84629006
132EZH2_27294783_Chip-Seq_NPCs_Mouse0.84383732
133VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84337391
134ERG_21242973_ChIP-ChIP_JURKAT_Human0.84216789
135NANOG_19829295_ChIP-Seq_ESCs_Human0.83806463

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.00321902
2MP0005670_abnormal_white_adipose4.17397563
3MP0000751_myopathy4.04592879
4MP0003646_muscle_fatigue3.97332326
5MP0004130_abnormal_muscle_cell3.51369560
6MP0004215_abnormal_myocardial_fiber3.09713971
7MP0005666_abnormal_adipose_tissue2.90351372
8MP0004084_abnormal_cardiac_muscle2.76220977
9MP0004036_abnormal_muscle_relaxation2.62165129
10MP0000749_muscle_degeneration2.53632286
11MP0005330_cardiomyopathy2.52740440
12MP0009780_abnormal_chondrocyte_physiolo2.27946962
13MP0004185_abnormal_adipocyte_glucose2.10761246
14MP0005620_abnormal_muscle_contractility2.08946778
15MP0004087_abnormal_muscle_fiber2.08780615
16MP0002653_abnormal_ependyma_morphology2.07262971
17MP0004859_abnormal_synaptic_plasticity2.05840259
18MP0005167_abnormal_blood-brain_barrier2.04273867
19MP0004145_abnormal_muscle_electrophysio2.03834463
20MP0005375_adipose_tissue_phenotype2.00987151
21MP0006276_abnormal_autonomic_nervous1.98348342
22MP0004484_altered_response_of1.96640024
23MP0002638_abnormal_pupillary_reflex1.94716159
24MP0003011_delayed_dark_adaptation1.93913303
25MP0002972_abnormal_cardiac_muscle1.89097152
26MP0006138_congestive_heart_failure1.84950987
27MP0010329_abnormal_lipoprotein_level1.81115731
28MP0002139_abnormal_hepatobiliary_system1.77360514
29MP0003137_abnormal_impulse_conducting1.77213019
30MP0005365_abnormal_bile_salt1.72466242
31MP0005646_abnormal_pituitary_gland1.71239451
32MP0002971_abnormal_brown_adipose1.68574567
33MP0000013_abnormal_adipose_tissue1.62813953
34MP0008775_abnormal_heart_ventricle1.62660848
35MP0000750_abnormal_muscle_regeneration1.62246397
36MP0001984_abnormal_olfaction1.61427214
37MP0002269_muscular_atrophy1.59674817
38MP0002106_abnormal_muscle_physiology1.57916514
39MP0000747_muscle_weakness1.57908899
40MP0001544_abnormal_cardiovascular_syste1.57565345
41MP0005385_cardiovascular_system_phenoty1.57565345
42MP0005360_urolithiasis1.56077611
43MP0000465_gastrointestinal_hemorrhage1.53846256
44MP0005085_abnormal_gallbladder_physiolo1.52297782
45MP0004085_abnormal_heartbeat1.51868415
46MP0002909_abnormal_adrenal_gland1.51200005
47MP0000759_abnormal_skeletal_muscle1.50759925
48MP0002822_catalepsy1.46705874
49MP0005369_muscle_phenotype1.38256348
50MP0002876_abnormal_thyroid_physiology1.36884636
51MP0008438_abnormal_cutaneous_collagen1.36353466
52MP0005645_abnormal_hypothalamus_physiol1.35583360
53MP0002118_abnormal_lipid_homeostasis1.35043968
54MP0003724_increased_susceptibility_to1.34066202
55MP0010630_abnormal_cardiac_muscle1.32619856
56MP0003828_pulmonary_edema1.32101792
57MP0005275_abnormal_skin_tensile1.30647259
58MP0008875_abnormal_xenobiotic_pharmacok1.28579346
59MP0001968_abnormal_touch/_nociception1.26033891
60MP0003635_abnormal_synaptic_transmissio1.25213614
61MP0005535_abnormal_body_temperature1.24070592
62MP0000003_abnormal_adipose_tissue1.22510815
63MP0005423_abnormal_somatic_nervous1.22224293
64MP0005334_abnormal_fat_pad1.22146259
65MP0001502_abnormal_circadian_rhythm1.20158683
66MP0008995_early_reproductive_senescence1.16840710
67MP0001501_abnormal_sleep_pattern1.16339430
68MP0009745_abnormal_behavioral_response1.16326348
69MP0003191_abnormal_cellular_cholesterol1.16177108
70MP0005551_abnormal_eye_electrophysiolog1.12014616
71MP0006036_abnormal_mitochondrial_physio1.09436456
72MP0003329_amyloid_beta_deposits1.08934967
73MP0001545_abnormal_hematopoietic_system1.06637217
74MP0005397_hematopoietic_system_phenotyp1.06637217
75MP0002108_abnormal_muscle_morphology1.04561592
76MP0002332_abnormal_exercise_endurance1.04251166
77MP0004510_myositis1.02972096
78MP0003252_abnormal_bile_duct1.02913883
79MP0009115_abnormal_fat_cell1.02752677
80MP0002933_joint_inflammation1.02396299
81MP0004233_abnormal_muscle_weight0.99615463
82MP0004270_analgesia0.99417973
83MP0002064_seizures0.98799923
84MP0009046_muscle_twitch0.98396216
85MP0002063_abnormal_learning/memory/cond0.97941929
86MP0010368_abnormal_lymphatic_system0.96773992
87MP0005253_abnormal_eye_physiology0.96423059
88MP0005448_abnormal_energy_balance0.95965552
89MP0001986_abnormal_taste_sensitivity0.95930721
90MP0002078_abnormal_glucose_homeostasis0.94535558
91MP0002733_abnormal_thermal_nociception0.91692677
92MP0003950_abnormal_plasma_membrane0.89726626
93MP0005503_abnormal_tendon_morphology0.89513845
94MP0003690_abnormal_glial_cell0.89373666
95MP0002736_abnormal_nociception_after0.89188013
96MP0000230_abnormal_systemic_arterial0.88445736
97MP0003880_abnormal_central_pattern0.86979063
98MP0008961_abnormal_basal_metabolism0.86978715
99MP0005332_abnormal_amino_acid0.86772962
100MP0003221_abnormal_cardiomyocyte_apopto0.86730824
101MP0002272_abnormal_nervous_system0.86503650
102MP0004043_abnormal_pH_regulation0.84836120
103MP0000383_abnormal_hair_follicle0.83962683
104MP0002735_abnormal_chemical_nociception0.83797991
105MP0002127_abnormal_cardiovascular_syste0.83757647
106MP0003045_fibrosis0.82502316
107MP0001661_extended_life_span0.81075413
108MP0005266_abnormal_metabolism0.78644832
109MP0005165_increased_susceptibility_to0.78263543
110MP0005647_abnormal_sex_gland0.77998146
111MP0000343_altered_response_to0.77133646
112MP0004924_abnormal_behavior0.77126405
113MP0005386_behavior/neurological_phenoty0.77126405
114MP0001486_abnormal_startle_reflex0.76418633
115MP0001970_abnormal_pain_threshold0.75277447
116MP0000733_abnormal_muscle_development0.75169639
117MP0002234_abnormal_pharynx_morphology0.75152815
118MP0003705_abnormal_hypodermis_morpholog0.74163779
119MP0009278_abnormal_bone_marrow0.74132285
120MP0004147_increased_porphyrin_level0.73059998
121MP0003879_abnormal_hair_cell0.72508398
122MP0005319_abnormal_enzyme/_coenzyme0.71970448
123MP0005452_abnormal_adipose_tissue0.71672205
124MP0005584_abnormal_enzyme/coenzyme_acti0.71587895
125MP0002572_abnormal_emotion/affect_behav0.71021737
126MP0005595_abnormal_vascular_smooth0.71006860
127MP0002067_abnormal_sensory_capabilities0.70622462
128MP0002557_abnormal_social/conspecific_i0.70319782
129MP0004142_abnormal_muscle_tone0.69626164
130MP0008874_decreased_physiological_sensi0.69567703
131MP0004272_abnormal_basement_membrane0.69086992
132MP0003195_calcinosis0.68658012
133MP0010386_abnormal_urinary_bladder0.68031831
134MP0003633_abnormal_nervous_system0.67172179
135MP0002970_abnormal_white_adipose0.67052974
136MP0000609_abnormal_liver_physiology0.65573363

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.39412718
2Exercise-induced myalgia (HP:0003738)5.29149099
3Calf muscle hypertrophy (HP:0008981)4.86361571
4Muscle fiber splitting (HP:0003555)4.82721451
5Muscle hypertrophy of the lower extremities (HP:0008968)4.68940821
6Hyporeflexia of lower limbs (HP:0002600)4.48992511
7Myoglobinuria (HP:0002913)4.14813364
8Ventricular tachycardia (HP:0004756)4.06112155
9Increased connective tissue (HP:0009025)3.96920229
10Difficulty running (HP:0009046)3.94247390
11Abnormality of the calf musculature (HP:0001430)3.87988313
12Atrial fibrillation (HP:0005110)3.81876782
13Right ventricular cardiomyopathy (HP:0011663)3.79788542
14Exercise-induced muscle cramps (HP:0003710)3.75726619
15Lipoatrophy (HP:0100578)3.54815566
16Primary atrial arrhythmia (HP:0001692)3.53600267
17Focal motor seizures (HP:0011153)3.48191242
18Oligomenorrhea (HP:0000876)3.41328027
19Ulnar deviation of the wrist (HP:0003049)3.40774836
20Distal arthrogryposis (HP:0005684)3.30702855
21Supraventricular tachycardia (HP:0004755)3.29974142
22EMG: myopathic abnormalities (HP:0003458)3.29288260
23Supraventricular arrhythmia (HP:0005115)3.27626830
24Syncope (HP:0001279)3.26300048
25Bundle branch block (HP:0011710)3.16256682
26Rhabdomyolysis (HP:0003201)3.12157206
27Hyperventilation (HP:0002883)3.09693529
28Type 1 muscle fiber predominance (HP:0003803)3.00640551
29Myopathic facies (HP:0002058)2.93621616
30Myotonia (HP:0002486)2.91615611
31Increased variability in muscle fiber diameter (HP:0003557)2.89990998
32Ketosis (HP:0001946)2.86729727
33Dilated cardiomyopathy (HP:0001644)2.83144210
34Hypoalphalipoproteinemia (HP:0003233)2.82271279
35Hyperglycinuria (HP:0003108)2.80283406
36Ketoacidosis (HP:0001993)2.77078598
37Prolonged QT interval (HP:0001657)2.75562849
38Areflexia of lower limbs (HP:0002522)2.72817325
39Complement deficiency (HP:0004431)2.71491890
40Aortic aneurysm (HP:0004942)2.69833638
41Abnormality of fatty-acid metabolism (HP:0004359)2.68084624
42Ventricular arrhythmia (HP:0004308)2.64153158
43Stomach cancer (HP:0012126)2.61625774
44Ventricular fibrillation (HP:0001663)2.59834801
45Heart block (HP:0012722)2.59381872
46Palpitations (HP:0001962)2.57804990
47Abnormality of the left ventricular outflow tract (HP:0011103)2.54624760
48Subaortic stenosis (HP:0001682)2.54624760
49Asymmetric septal hypertrophy (HP:0001670)2.54211985
50Abnormality of skeletal muscle fiber size (HP:0012084)2.49776916
51Frequent falls (HP:0002359)2.49130416
52Centrally nucleated skeletal muscle fibers (HP:0003687)2.44660145
53Atrioventricular block (HP:0001678)2.44453159
54Abnormal atrioventricular conduction (HP:0005150)2.43718766
55Muscle stiffness (HP:0003552)2.42624686
56Abnormality of glycine metabolism (HP:0010895)2.40373196
57Abnormality of serine family amino acid metabolism (HP:0010894)2.40373196
58Muscle fiber inclusion bodies (HP:0100299)2.39606826
59Dysmetric saccades (HP:0000641)2.37959268
60Hypoglycemic coma (HP:0001325)2.36795512
61Epidermoid cyst (HP:0200040)2.36150596
62Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.35952756
63Hyperammonemia (HP:0001987)2.35168814
64Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.34525724
65Hyperkalemia (HP:0002153)2.32215700
66Acanthosis nigricans (HP:0000956)2.28702270
67Gaze-evoked nystagmus (HP:0000640)2.28515757
68Broad metatarsal (HP:0001783)2.28285029
69Cerebral palsy (HP:0100021)2.27908060
70Generalized muscle weakness (HP:0003324)2.27288279
71Deep venous thrombosis (HP:0002625)2.24732973
72Facial diplegia (HP:0001349)2.23556188
73Hyperlipoproteinemia (HP:0010980)2.23157910
74Abnormal EKG (HP:0003115)2.20713659
75Broad-based gait (HP:0002136)2.20580024
76Difficulty climbing stairs (HP:0003551)2.19450711
77Testicular atrophy (HP:0000029)2.17709150
78Myokymia (HP:0002411)2.15248508
79Abnormality of the ischium (HP:0003174)2.13687779
80Xanthomatosis (HP:0000991)2.12219793
81Abnormality of dicarboxylic acid metabolism (HP:0010995)2.10505459
82Dicarboxylic aciduria (HP:0003215)2.10505459
83Round ear (HP:0100830)2.09930014
84Mildly elevated creatine phosphokinase (HP:0008180)2.09327982
85Neck muscle weakness (HP:0000467)2.09214138
86Clumsiness (HP:0002312)2.07020835
87Prolonged bleeding time (HP:0003010)2.06700791
88Insulin-resistant diabetes mellitus (HP:0000831)2.04231266
89Cerebral edema (HP:0002181)2.02091501
90Spontaneous abortion (HP:0005268)2.01606746
91Focal seizures (HP:0007359)2.00133079
92Neoplasm of the heart (HP:0100544)1.99033387
93Progressive cerebellar ataxia (HP:0002073)1.98953301
94Hypoplastic ischia (HP:0003175)1.96756989
95Skin nodule (HP:0200036)1.96746999
96Renal cortical cysts (HP:0000803)1.95933422
97Muscular dystrophy (HP:0003560)1.95054435
98Increased muscle lipid content (HP:0009058)1.94716869
99Proximal amyotrophy (HP:0007126)1.92449500
100Pancreatic fibrosis (HP:0100732)1.92279616
101Pulmonary artery stenosis (HP:0004415)1.91874224
102Toxemia of pregnancy (HP:0100603)1.91797414
103Absent phalangeal crease (HP:0006109)1.91469464
104Hip contracture (HP:0003273)1.91066116
105Limited hip movement (HP:0008800)1.90641605
106Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.89792841
107Cholelithiasis (HP:0001081)1.89218310
108Atonic seizures (HP:0010819)1.88526976
109Pancreatic cysts (HP:0001737)1.88521997
110Hypolipoproteinemia (HP:0010981)1.87677854
111Distal lower limb amyotrophy (HP:0008944)1.87651614
112Pheochromocytoma (HP:0002666)1.83807069
113Abnormal social behavior (HP:0012433)1.82924934
114Impaired social interactions (HP:0000735)1.82924934
115Type II lissencephaly (HP:0007260)1.82750105
116Hypertriglyceridemia (HP:0002155)1.82485219
117Distal lower limb muscle weakness (HP:0009053)1.81425389
118Anterior segment dysgenesis (HP:0007700)1.81373760
119Nemaline bodies (HP:0003798)1.81063749
120Decreased circulating renin level (HP:0003351)1.81049426
121Genetic anticipation (HP:0003743)1.79386831
122Congenital stationary night blindness (HP:0007642)1.79114060
123Febrile seizures (HP:0002373)1.78574422
124Tachypnea (HP:0002789)1.78127192
125Cerebellar dysplasia (HP:0007033)1.78032733
126Metabolic acidosis (HP:0001942)1.77926743
127Bulbar palsy (HP:0001283)1.75856660
128Waddling gait (HP:0002515)1.75845659
129Hyperglycinemia (HP:0002154)1.75171183
130Generalized tonic-clonic seizures (HP:0002069)1.73815411
131Left ventricular hypertrophy (HP:0001712)1.73715355
132Rimmed vacuoles (HP:0003805)1.73589019
133Weak cry (HP:0001612)1.73338697
134Nephronophthisis (HP:0000090)1.72808668
135Bile duct proliferation (HP:0001408)1.72755136
136Abnormal biliary tract physiology (HP:0012439)1.72755136
137Scapular winging (HP:0003691)1.72076578
138Abnormality of the renal cortex (HP:0011035)1.71969642
139Malignant hyperthermia (HP:0002047)1.71783738
140Hyperglycemia (HP:0003074)1.71313447
141EMG: neuropathic changes (HP:0003445)1.70242834
142Abnormality of complement system (HP:0005339)1.69509050
143Abnormal gallbladder morphology (HP:0012437)1.69386688
144Type 2 muscle fiber atrophy (HP:0003554)1.67581050
145True hermaphroditism (HP:0010459)1.64926120
146Steppage gait (HP:0003376)1.63248269

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK23.40477481
2TTN3.32865737
3MAP4K23.29340825
4OBSCN3.10285438
5PHKG23.02457145
6PHKG13.02457145
7PDK32.62605266
8PDK42.62605266
9BCKDK2.49716789
10CAMK1G2.27340210
11CAMK1D2.22959425
12CASK2.22573329
13MYLK2.20460710
14EPHA32.11945186
15NTRK32.05351156
16SIK11.99896433
17DMPK1.93446733
18MAP2K41.85678216
19PIK3CA1.84694810
20MUSK1.83102585
21MAPKAPK31.80269115
22PINK11.78918874
23TIE11.74906663
24MAP3K41.74129234
25DAPK21.73874494
26PDK21.73321784
27INSRR1.73268515
28TRIB31.69770076
29MARK11.66930633
30EPHA41.65280875
31ICK1.41393715
32MAPK131.36802590
33MAP3K71.30314562
34RIPK11.25854869
35STK391.20402089
36MAP2K71.19564595
37MAP3K61.19250594
38ADRBK21.15982901
39PRKAA21.14526194
40MAP2K21.09514820
41LATS11.08304375
42FER1.07425106
43AKT31.00908452
44PKN10.98720736
45PTK2B0.97863879
46FES0.96838229
47MAPK120.94973875
48SGK30.92591171
49KDR0.92556533
50MAP3K120.92460477
51GRK10.92239166
52ZAK0.91967451
53MAPK70.91319224
54PRKD30.90222997
55CAMK10.88441171
56CAMK2D0.88147015
57FGFR20.87064911
58OXSR10.86373671
59TRPM70.86350943
60CAMK2A0.85260904
61EEF2K0.84369393
62SGK20.83717816
63ERBB40.81778754
64PRKCH0.81467907
65PRKAA10.80615909
66MAPK40.78544297
67NME10.77633795
68PRKD10.76438021
69ROCK10.74858480
70WNK40.73868271
71SGK4940.70954237
72SGK2230.70954237
73PRKCE0.70376797
74NLK0.70323721
75PAK30.68605743
76BMPR1B0.68590652
77GRK70.67479779
78PDGFRA0.66370322
79PDPK10.66139723
80KIT0.64968426
81PRPF4B0.63992681
82ADRBK10.63878280
83MST1R0.63482875
84NUAK10.62505635
85SGK10.61486555
86CAMK40.61175271
87DAPK10.59878769
88STK380.59558743
89CAMK2B0.59525132
90MAPK150.59215818
91TGFBR20.58782336
92CAMK2G0.58449215
93PDK10.57779356
94CDK50.57187935
95RPS6KA60.54666557
96PRKACG0.54233339
97ERN10.53998895
98MAP3K10.53126396
99GRK50.52992260
100SYK0.52403501
101EPHB10.52312023
102RPS6KA20.52121666
103EPHB20.52113081
104PRKG10.52111741
105IKBKB0.52081077
106GRK60.51218630
107JAK10.50396803
108PRKACB0.50359675
109STK110.49743993
110NTRK20.49385484
111TXK0.48075411
112ROCK20.47398490
113PKN20.47291463
114RET0.45379760
115PRKACA0.44661049
116MARK20.44496035
117PAK60.44155747
118DAPK30.44116593
119RPS6KC10.44107914
120RPS6KL10.44107914
121MAP2K10.43833185
122MAPK30.43489193
123FGFR40.43357344
124STK38L0.42823958
125WNK30.42752195
126RPS6KA30.42135385
127FGFR30.42104772
128CHUK0.41779925
129IKBKE0.40481033
130CDC42BPA0.40418061
131WNK10.40344457
132MAP2K60.40341712
133DYRK1A0.40059496
134MAP3K110.39840352
135JAK20.39478466
136MAP3K50.38329649
137PIK3CG0.38329030
138TAOK30.37582145
139FRK0.37008407
140TNK20.35932938
141RPS6KA50.35016024
142TEC0.34851446
143PRKCQ0.34011346
144BTK0.33372948

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.13256825
2Propanoate metabolism_Homo sapiens_hsa006403.05567508
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.71237792
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.69680386
5Fatty acid degradation_Homo sapiens_hsa000712.48889578
6Fatty acid metabolism_Homo sapiens_hsa012122.39789790
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31635077
8PPAR signaling pathway_Homo sapiens_hsa033202.30335782
9Nitrogen metabolism_Homo sapiens_hsa009102.30166748
10Fatty acid biosynthesis_Homo sapiens_hsa000612.16103392
11Linoleic acid metabolism_Homo sapiens_hsa005912.12532543
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.98376739
13Dilated cardiomyopathy_Homo sapiens_hsa054141.88211210
14Butanoate metabolism_Homo sapiens_hsa006501.86287848
15Arginine biosynthesis_Homo sapiens_hsa002201.85487007
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.72577538
17Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.67705051
18Arachidonic acid metabolism_Homo sapiens_hsa005901.66353137
19Cardiac muscle contraction_Homo sapiens_hsa042601.64939458
20Pyruvate metabolism_Homo sapiens_hsa006201.64831955
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.64181085
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62004642
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56052788
24Carbon metabolism_Homo sapiens_hsa012001.47918891
25beta-Alanine metabolism_Homo sapiens_hsa004101.40145868
26Histidine metabolism_Homo sapiens_hsa003401.33750843
27Fatty acid elongation_Homo sapiens_hsa000621.32433996
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30732584
29Nicotine addiction_Homo sapiens_hsa050331.30722306
30Tryptophan metabolism_Homo sapiens_hsa003801.26025232
31Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.25400880
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.24839236
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.22235616
34Adipocytokine signaling pathway_Homo sapiens_hsa049201.21198622
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19522238
36Platelet activation_Homo sapiens_hsa046111.18997346
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18746074
38Phototransduction_Homo sapiens_hsa047441.17722921
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16722204
40Glycerolipid metabolism_Homo sapiens_hsa005611.14601720
41Circadian entrainment_Homo sapiens_hsa047131.11624909
42Retinol metabolism_Homo sapiens_hsa008301.11284477
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11166611
44Calcium signaling pathway_Homo sapiens_hsa040201.10306068
45Peroxisome_Homo sapiens_hsa041461.07093512
46Glucagon signaling pathway_Homo sapiens_hsa049221.06109161
47Renin secretion_Homo sapiens_hsa049241.06088089
48Chemical carcinogenesis_Homo sapiens_hsa052041.03756885
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03436217
50Complement and coagulation cascades_Homo sapiens_hsa046101.01646167
51Salivary secretion_Homo sapiens_hsa049701.00192486
52Insulin resistance_Homo sapiens_hsa049310.97976910
53AMPK signaling pathway_Homo sapiens_hsa041520.96155826
54GABAergic synapse_Homo sapiens_hsa047270.95122477
55Bile secretion_Homo sapiens_hsa049760.93708064
56Insulin signaling pathway_Homo sapiens_hsa049100.92589479
57Starch and sucrose metabolism_Homo sapiens_hsa005000.92106254
58Type II diabetes mellitus_Homo sapiens_hsa049300.91058299
59Morphine addiction_Homo sapiens_hsa050320.86328113
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86238543
61Caffeine metabolism_Homo sapiens_hsa002320.85871127
62Gastric acid secretion_Homo sapiens_hsa049710.85789550
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85608226
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84399695
65Long-term depression_Homo sapiens_hsa047300.83036920
66Oxytocin signaling pathway_Homo sapiens_hsa049210.82063944
67Glutamatergic synapse_Homo sapiens_hsa047240.81333212
68cAMP signaling pathway_Homo sapiens_hsa040240.80341486
69Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78946998
70Taste transduction_Homo sapiens_hsa047420.78068500
71Arginine and proline metabolism_Homo sapiens_hsa003300.77004715
72Phenylalanine metabolism_Homo sapiens_hsa003600.76794761
73Regulation of autophagy_Homo sapiens_hsa041400.76782869
74ABC transporters_Homo sapiens_hsa020100.76539208
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76179321
76Insulin secretion_Homo sapiens_hsa049110.75236470
77Long-term potentiation_Homo sapiens_hsa047200.74920665
78Lysine degradation_Homo sapiens_hsa003100.73866479
79Biosynthesis of amino acids_Homo sapiens_hsa012300.70910554
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70271680
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.70157078
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69886059
83Dorso-ventral axis formation_Homo sapiens_hsa043200.68938269
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.68788211
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68028426
86Fat digestion and absorption_Homo sapiens_hsa049750.67965843
87Alzheimers disease_Homo sapiens_hsa050100.67529274
88Oxidative phosphorylation_Homo sapiens_hsa001900.67198551
89Notch signaling pathway_Homo sapiens_hsa043300.63619970
90Synaptic vesicle cycle_Homo sapiens_hsa047210.58965431
91Circadian rhythm_Homo sapiens_hsa047100.58607331
92Pancreatic secretion_Homo sapiens_hsa049720.58200944
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56890857
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55639685
95Amphetamine addiction_Homo sapiens_hsa050310.55028877
96Ether lipid metabolism_Homo sapiens_hsa005650.54150039
97Viral myocarditis_Homo sapiens_hsa054160.52858231
98Olfactory transduction_Homo sapiens_hsa047400.51825748
99GnRH signaling pathway_Homo sapiens_hsa049120.51443727
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50839543
101Cholinergic synapse_Homo sapiens_hsa047250.49681000
102Staphylococcus aureus infection_Homo sapiens_hsa051500.49634153
103Tyrosine metabolism_Homo sapiens_hsa003500.48615359
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47860526
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46708177
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46097104
107Focal adhesion_Homo sapiens_hsa045100.45785705
108Parkinsons disease_Homo sapiens_hsa050120.44699540
109ECM-receptor interaction_Homo sapiens_hsa045120.43603553
110MAPK signaling pathway_Homo sapiens_hsa040100.43524750
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41312147
112Dopaminergic synapse_Homo sapiens_hsa047280.41029631
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40704754
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40154778
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38943796
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35510150
117FoxO signaling pathway_Homo sapiens_hsa040680.34790317
118Estrogen signaling pathway_Homo sapiens_hsa049150.34241149
119Ovarian steroidogenesis_Homo sapiens_hsa049130.33465634
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32495312
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31861463
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31647204
123Serotonergic synapse_Homo sapiens_hsa047260.31421083
124Gap junction_Homo sapiens_hsa045400.31186805
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.31169380

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