ZBED9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)9.27512625
2replicative senescence (GO:0090399)8.23651383
3eosinophil chemotaxis (GO:0048245)7.97567027
4cellular response to ethanol (GO:0071361)7.79357634
5prenylation (GO:0097354)7.35955677
6protein prenylation (GO:0018342)7.35955677
7regulation of lymphocyte chemotaxis (GO:1901623)7.15945364
8eosinophil migration (GO:0072677)7.14081458
9regulation of syncytium formation by plasma membrane fusion (GO:0060142)6.89719093
10hematopoietic stem cell proliferation (GO:0071425)6.89263408
11positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)6.69174280
12activation of protein kinase A activity (GO:0034199)6.08170428
13cAMP biosynthetic process (GO:0006171)5.96344466
14post-anal tail morphogenesis (GO:0036342)5.89819461
15regulation of prostaglandin secretion (GO:0032306)5.79896676
16regulation of DNA damage checkpoint (GO:2000001)5.61520848
17sulfation (GO:0051923)5.50475762
18viral mRNA export from host cell nucleus (GO:0046784)5.46832645
19positive regulation of prostaglandin secretion (GO:0032308)4.97934451
20regulation of nitric-oxide synthase biosynthetic process (GO:0051769)4.87515509
21osteoclast differentiation (GO:0030316)4.67116248
22monocyte chemotaxis (GO:0002548)4.34641744
23spleen development (GO:0048536)4.33068669
24cell adhesion mediated by integrin (GO:0033627)4.32337554
25membrane protein intracellular domain proteolysis (GO:0031293)4.28881715
26regulation of macrophage chemotaxis (GO:0010758)4.24230169
27wound healing, spreading of epidermal cells (GO:0035313)4.22112131
28negative regulation of catenin import into nucleus (GO:0035414)4.07584493
29regulation of endothelial cell differentiation (GO:0045601)3.94662365
30cellular extravasation (GO:0045123)3.89554730
31neutrophil mediated immunity (GO:0002446)3.72629193
32membrane protein ectodomain proteolysis (GO:0006509)3.63471338
33regulation of mononuclear cell migration (GO:0071675)3.54942085
34DNA replication-dependent nucleosome organization (GO:0034723)3.54464862
35DNA replication-dependent nucleosome assembly (GO:0006335)3.54464862
36positive regulation of lymphocyte migration (GO:2000403)3.46416941
37cellular response to exogenous dsRNA (GO:0071360)3.28537626
38segmentation (GO:0035282)3.27158113
39regulation of icosanoid secretion (GO:0032303)3.26262063
40positive regulation of RNA splicing (GO:0033120)3.24912056
41regulation of lymphocyte migration (GO:2000401)3.22427408
42response to lipoprotein particle (GO:0055094)3.21926232
43cellular response to interleukin-1 (GO:0071347)3.20047018
44somitogenesis (GO:0001756)3.17562277
45negative regulation of T-helper cell differentiation (GO:0045623)3.14606061
46negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.14606061
47positive regulation of fatty acid biosynthetic process (GO:0045723)3.12682689
48germinal center formation (GO:0002467)3.06943808
49tryptophan metabolic process (GO:0006568)3.06739669
50indole-containing compound catabolic process (GO:0042436)3.06540843
51indolalkylamine catabolic process (GO:0046218)3.06540843
52tryptophan catabolic process (GO:0006569)3.06540843
53positive regulation of icosanoid secretion (GO:0032305)3.06224368
54regulation of T cell chemotaxis (GO:0010819)3.03954083
55positive regulation of T cell chemotaxis (GO:0010820)3.03954083
56regulation of skeletal muscle contraction (GO:0014819)3.03718480
57interleukin-1-mediated signaling pathway (GO:0070498)3.03528656
58thymus development (GO:0048538)3.00338761
59lipopolysaccharide-mediated signaling pathway (GO:0031663)2.99771870
60negative regulation of systemic arterial blood pressure (GO:0003085)2.95244482
61cyclic purine nucleotide metabolic process (GO:0052652)2.93477723
62kynurenine metabolic process (GO:0070189)2.91930443
63negative regulation of leukocyte chemotaxis (GO:0002689)2.91283284
643-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.91032929
65purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.91032929
66cAMP metabolic process (GO:0046058)2.90971993
67cyclic nucleotide biosynthetic process (GO:0009190)2.83526859
68mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.78133470
69mitochondrial respiratory chain complex I assembly (GO:0032981)2.78133470
70NADH dehydrogenase complex assembly (GO:0010257)2.78133470
71regulation of vitamin D biosynthetic process (GO:0060556)2.76259967
72regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.74929334
73innate immune response in mucosa (GO:0002227)2.74761270
74interferon-gamma secretion (GO:0072643)2.71281330
75righting reflex (GO:0060013)2.69639499
76T cell mediated immunity (GO:0002456)2.67476732
77positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.64859618
78positive regulation of osteoclast differentiation (GO:0045672)2.64097071
79myeloid leukocyte mediated immunity (GO:0002444)2.63074573
80membrane protein proteolysis (GO:0033619)2.62935733
81wound healing, spreading of cells (GO:0044319)2.62177171
82positive regulation of fatty acid transport (GO:2000193)2.61373683
83vitamin A metabolic process (GO:0006776)2.55660919
84granulocyte chemotaxis (GO:0071621)2.54625890
85dendritic spine morphogenesis (GO:0060997)2.54579985
86membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.53964199
87detection of calcium ion (GO:0005513)2.53924717
88negative regulation of Rho protein signal transduction (GO:0035024)2.53751034
89regulation of inositol phosphate biosynthetic process (GO:0010919)2.53744859
90negative regulation of fibrinolysis (GO:0051918)2.49443714
91granulocyte migration (GO:0097530)2.44499372
92negative regulation of interleukin-17 production (GO:0032700)2.43869995
93protein localization to synapse (GO:0035418)2.43487609
94regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.40706585
95positive regulation of leukocyte chemotaxis (GO:0002690)2.40666344
96lymphangiogenesis (GO:0001946)2.40115404
97cardiac muscle hypertrophy (GO:0003300)2.39841566
98cellular biogenic amine catabolic process (GO:0042402)2.39571403
99amine catabolic process (GO:0009310)2.39571403
100regulation of somitogenesis (GO:0014807)14.4533859

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.11962007
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.83299066
3SMAD_19615063_ChIP-ChIP_OVARY_Human3.03102896
4AR_21572438_ChIP-Seq_LNCaP_Human2.48556106
5EGR1_23403033_ChIP-Seq_LIVER_Mouse2.31826155
6RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.28326611
7GATA1_22025678_ChIP-Seq_K562_Human2.24534699
8HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.23307878
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse13.2118763
10STAT6_21828071_ChIP-Seq_BEAS2B_Human10.0209429
11TP53_16413492_ChIP-PET_HCT116_Human1.84313147
12IRF1_19129219_ChIP-ChIP_H3396_Human1.73310747
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69540997
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63542575
15VDR_22108803_ChIP-Seq_LS180_Human1.47399072
16IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38412297
17MYB_21317192_ChIP-Seq_ERMYB_Mouse1.37415146
18LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36148229
19ELK4_26923725_Chip-Seq_MESODERM_Mouse1.35826569
20VDR_24787735_ChIP-Seq_THP-1_Human1.31317990
21EZH2_22144423_ChIP-Seq_EOC_Human1.29606959
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26745944
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.19403946
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19401602
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.18688981
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17020838
27GATA1_26923725_Chip-Seq_HPCs_Mouse1.12889270
28IGF1R_20145208_ChIP-Seq_DFB_Human1.11754240
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10817473
30PKCTHETA_26484144_Chip-Seq_BREAST_Human1.09640807
31GBX2_23144817_ChIP-Seq_PC3_Human1.06542093
32ER_23166858_ChIP-Seq_MCF-7_Human1.02606599
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01275223
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99974740
35ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.98603918
36MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.96289546
37GATA2_19941826_ChIP-Seq_K562_Human0.95803782
38E2F1_18555785_Chip-Seq_ESCs_Mouse0.94955330
39CJUN_26792858_Chip-Seq_BT549_Human0.94475855
40VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92225194
41SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.91983305
42FUS_26573619_Chip-Seq_HEK293_Human0.91069927
43SMAD3_21741376_ChIP-Seq_EPCs_Human0.90945715
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89151963
45ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88175029
46GATA1_19941826_ChIP-Seq_K562_Human0.87660337
47GF1B_26923725_Chip-Seq_HPCs_Mouse0.87393074
48CBX2_27304074_Chip-Seq_ESCs_Mouse0.87196295
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.85798078
50CBP_20019798_ChIP-Seq_JUKART_Human0.85505149
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85505149
52AHR_22903824_ChIP-Seq_MCF-7_Human0.83884320
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83545159
54ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82235878
55CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.82022648
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.81541332
57EP300_21415370_ChIP-Seq_HL-1_Mouse0.81379572
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80917759
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79915922
60GF1_26923725_Chip-Seq_HPCs_Mouse0.79053107
61PCGF2_27294783_Chip-Seq_NPCs_Mouse0.76872744
62NOTCH1_21737748_ChIP-Seq_TLL_Human0.76495411
63HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76160722
64PPAR_26484153_Chip-Seq_NCI-H1993_Human0.74980179
65ZNF217_24962896_ChIP-Seq_MCF-7_Human0.74323575
66NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74091577
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74091577
68STAT3_23295773_ChIP-Seq_U87_Human0.73777143
69ZNF274_21170338_ChIP-Seq_K562_Hela0.73743050
70LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.73660427
71SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.72645889
72STAT3_18555785_Chip-Seq_ESCs_Mouse0.72005732
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.71534348
74KDM2B_26808549_Chip-Seq_REH_Human0.70873502
75TAF15_26573619_Chip-Seq_HEK293_Human0.70185874
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.69765117
77E2F1_21310950_ChIP-Seq_MCF-7_Human0.69764177
78EZH2_18974828_ChIP-Seq_MESCs_Mouse0.69383601
79RNF2_18974828_ChIP-Seq_MESCs_Mouse0.69383601
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.68496486
81GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68292460
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.67806863
83SALL4_22934838_ChIP-ChIP_CD34+_Human0.67201797
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.67021651
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.66505722
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.65373297
87POU5F1_16153702_ChIP-ChIP_HESCs_Human0.64993955
88CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.63835832
89SMAD4_21799915_ChIP-Seq_A2780_Human0.60742383
90RXR_22108803_ChIP-Seq_LS180_Human0.60662375
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.60429680
92FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.60058172
93FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.59736958
94SUZ12_27294783_Chip-Seq_NPCs_Mouse0.59716165
95ETS1_22383799_ChIP-Seq_G1ME_Mouse0.59590959
96JUN_21703547_ChIP-Seq_K562_Human0.59495340
97FOXM1_26456572_ChIP-Seq_MCF-7_Human0.59366469
98UBF1/2_26484160_Chip-Seq_HMECs_Human0.59236600
99SMAD4_21741376_ChIP-Seq_EPCs_Human0.58963596
100JARID2_20075857_ChIP-Seq_MESCs_Mouse0.58471354

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.94373432
2MP0009764_decreased_sensitivity_to4.45309907
3MP0002877_abnormal_melanocyte_morpholog4.30779475
4MP0005084_abnormal_gallbladder_morpholo3.93215723
5MP0003221_abnormal_cardiomyocyte_apopto3.13087668
6MP0005451_abnormal_body_composition3.04495969
7MP0000371_diluted_coat_color3.02616293
8MP0003252_abnormal_bile_duct2.86487003
9MP0009840_abnormal_foam_cell2.72466177
10MP0004233_abnormal_muscle_weight2.66180754
11MP0002928_abnormal_bile_duct2.57238050
12MP0005167_abnormal_blood-brain_barrier2.51701970
13MP0003693_abnormal_embryo_hatching2.16508260
14MP0003950_abnormal_plasma_membrane2.09842275
15MP0003183_abnormal_peptide_metabolism1.98409394
16MP0008872_abnormal_physiological_respon1.78609425
17MP0002090_abnormal_vision1.78528284
18MP0000750_abnormal_muscle_regeneration1.78044768
19MP0003828_pulmonary_edema1.77026582
20MP0004134_abnormal_chest_morphology1.72717666
21MP0005409_darkened_coat_color1.67594758
22MP0000013_abnormal_adipose_tissue1.64204782
23MP0003656_abnormal_erythrocyte_physiolo1.63857533
24MP0001879_abnormal_lymphatic_vessel1.59970707
25MP0002075_abnormal_coat/hair_pigmentati1.55999799
26MP0004270_analgesia1.53290570
27MP0004264_abnormal_extraembryonic_tissu1.51856508
28MP0008770_decreased_survivor_rate1.51765198
29MP0002932_abnormal_joint_morphology1.50502662
30MP0004272_abnormal_basement_membrane1.48477028
31MP0005464_abnormal_platelet_physiology1.42723229
32MP0005083_abnormal_biliary_tract1.40666493
33MP0003646_muscle_fatigue1.36375302
34MP0008004_abnormal_stomach_pH1.34941275
35MP0000343_altered_response_to1.34713466
36MP0005187_abnormal_penis_morphology1.33791909
37MP0002138_abnormal_hepatobiliary_system1.33160416
38MP0005410_abnormal_fertilization1.25959379
39MP0002009_preneoplasia1.25610070
40MP0002160_abnormal_reproductive_system1.25383997
41MP0004130_abnormal_muscle_cell1.23045872
42MP0000747_muscle_weakness1.21373360
43MP0001270_distended_abdomen1.18006944
44MP0001186_pigmentation_phenotype1.17816886
45MP0000163_abnormal_cartilage_morphology1.15597219
46MP0004484_altered_response_of1.14759679
47MP0004885_abnormal_endolymph1.10127284
48MP0002127_abnormal_cardiovascular_syste1.09835883
49MP0000678_abnormal_parathyroid_gland1.08921189
50MP0000003_abnormal_adipose_tissue1.08730699
51MP0000749_muscle_degeneration1.08431677
52MP0002638_abnormal_pupillary_reflex1.06171887
53MP0008260_abnormal_autophagy1.03745153
54MP0002419_abnormal_innate_immunity1.03467915
55MP0005220_abnormal_exocrine_pancreas1.01522137
56MP0003567_abnormal_fetal_cardiomyocyte1.00938423
57MP0002332_abnormal_exercise_endurance0.97008183
58MP0003315_abnormal_perineum_morphology0.95816885
59MP0002095_abnormal_skin_pigmentation0.91639833
60MP0000613_abnormal_salivary_gland0.91583477
61MP0009115_abnormal_fat_cell0.90667320
62MP0005385_cardiovascular_system_phenoty0.88860049
63MP0001544_abnormal_cardiovascular_syste0.88860049
64MP0009250_abnormal_appendicular_skeleto0.87987559
65MP0003633_abnormal_nervous_system0.87316625
66MP0004215_abnormal_myocardial_fiber0.87224904
67MP0003011_delayed_dark_adaptation0.84483585
68MP0003436_decreased_susceptibility_to0.83727335
69MP0000049_abnormal_middle_ear0.82588601
70MP0009765_abnormal_xenobiotic_induced0.82085355
71MP0006138_congestive_heart_failure0.81904845
72MP0000609_abnormal_liver_physiology0.81565737
73MP0004133_heterotaxia0.81477039
74MP0005166_decreased_susceptibility_to0.81195503
75MP0005076_abnormal_cell_differentiation0.81148005
76MP0002111_abnormal_tail_morphology0.81140494
77MP0000733_abnormal_muscle_development0.80355559
78MP0003303_peritoneal_inflammation0.79693789
79MP0002972_abnormal_cardiac_muscle0.79075844
80MP0002089_abnormal_postnatal_growth/wei0.77867664
81MP0009046_muscle_twitch0.76771650
82MP0005389_reproductive_system_phenotype0.73185312
83MP0000631_abnormal_neuroendocrine_gland0.72093550
84MP0001324_abnormal_eye_pigmentation0.70510097
85MP0006276_abnormal_autonomic_nervous0.67689171
86MP0003091_abnormal_cell_migration0.67277594
87MP0002163_abnormal_gland_morphology0.66842754
88MP0004197_abnormal_fetal_growth/weight/0.66703137
89MP0002452_abnormal_antigen_presenting0.65730199
90MP0005164_abnormal_response_to0.65164477
91MP0003959_abnormal_lean_body0.64035193
92MP0010234_abnormal_vibrissa_follicle0.63957809
93MP0002139_abnormal_hepatobiliary_system0.62938738
94MP0001175_abnormal_lung_morphology0.62454046
95MP0005423_abnormal_somatic_nervous0.62385473
96MP0002106_abnormal_muscle_physiology0.61613040
97MP0005334_abnormal_fat_pad0.61581869
98MP0002113_abnormal_skeleton_development0.60723899
99MP0003631_nervous_system_phenotype0.58230366
100MP0001191_abnormal_skin_condition0.58173051

Predicted human phenotypes

RankGene SetZ-score
1Hemiplegia (HP:0002301)6.11331047
2Myelomeningocele (HP:0002475)5.25009565
3Abnormality of the intervertebral disk (HP:0005108)5.09899006
4Abnormality of the odontoid process (HP:0003310)5.01518528
5Rough bone trabeculation (HP:0100670)4.88227478
6Tongue fasciculations (HP:0001308)4.56292456
7Slow saccadic eye movements (HP:0000514)4.47098011
8Muscle fibrillation (HP:0010546)4.46109512
9Short femoral neck (HP:0100864)4.44414587
10Premature graying of hair (HP:0002216)4.27397794
11Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.92415553
12Pathologic fracture (HP:0002756)3.89518865
13Abnormal trabecular bone morphology (HP:0100671)3.86684273
14Vertebral fusion (HP:0002948)3.81433782
15Hemivertebrae (HP:0002937)3.57176667
16Prominent occiput (HP:0000269)3.27629142
17Aplasia/hypoplasia of the femur (HP:0005613)3.19975145
18Oligodontia (HP:0000677)3.07213830
19Impaired smooth pursuit (HP:0007772)3.02157994
20Morphological abnormality of the pyramidal tract (HP:0002062)2.97706157
21Meningocele (HP:0002435)2.91863865
22Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.74736556
23Bone marrow hypocellularity (HP:0005528)2.64071991
24Duplicated collecting system (HP:0000081)2.60121363
25Abnormality of the renal collecting system (HP:0004742)2.52752909
26Spina bifida occulta (HP:0003298)2.35042413
27Abnormality of ocular smooth pursuit (HP:0000617)2.31905251
28Deformed sella turcica (HP:0002681)2.26880924
29Ankyloglossia (HP:0010296)2.24639432
30Cellular immunodeficiency (HP:0005374)2.19889782
31Persistence of primary teeth (HP:0006335)2.18183713
32Abnormality of the lumbar spine (HP:0100712)2.16040765
33Calf muscle hypertrophy (HP:0008981)2.08311928
34Abnormality of pyrimidine metabolism (HP:0004353)2.03590940
35Amelogenesis imperfecta (HP:0000705)2.02968159
36Oral leukoplakia (HP:0002745)12.0842314
37Anomalous pulmonary venous return (HP:0010772)12.0076657
38Abnormality of the pulmonary veins (HP:0011718)10.6311048
39Sparse lateral eyebrow (HP:0005338)1.98140880
40Adactyly (HP:0009776)1.97965309
41Hamartoma of the eye (HP:0010568)1.95639445
42Anonychia (HP:0001798)1.94419694
43Blepharitis (HP:0000498)1.93716136
44Broad forehead (HP:0000337)1.90177188
45Drooling (HP:0002307)1.89625898
46Aplasia cutis congenita (HP:0001057)1.88327153
47J-shaped sella turcica (HP:0002680)1.88178015
48Aortic regurgitation (HP:0001659)1.86250311
49Short thorax (HP:0010306)1.86001906
50Ureteral duplication (HP:0000073)1.82414923
51Aseptic necrosis (HP:0010885)1.81300043
52Osteomalacia (HP:0002749)1.80449268
53Chromosomal breakage induced by crosslinking agents (HP:0003221)1.79777843
54Abnormality of the nasal septum (HP:0000419)1.79527099
55Neoplasm of the pancreas (HP:0002894)1.79029864
56Muscle hypertrophy of the lower extremities (HP:0008968)1.78443239
57Abnormality of the frontal sinuses (HP:0002687)1.78400914
58Abnormal pancreas size (HP:0012094)1.77309883
59Hyporeflexia of lower limbs (HP:0002600)1.76071381
60Broad ribs (HP:0000885)1.74984198
61Spinal cord lesions (HP:0100561)1.74477603
62Syringomyelia (HP:0003396)1.74477603
63Genetic anticipation (HP:0003743)1.73674933
64Ectopic kidney (HP:0000086)1.72123961
65Upper motor neuron abnormality (HP:0002127)1.71130357
66Neoplasm of the heart (HP:0100544)1.70327302
67Difficulty climbing stairs (HP:0003551)1.69617072
68Excessive salivation (HP:0003781)1.68495620
69Alveolar cell carcinoma (HP:0006519)1.67132254
70Pelvic girdle muscle weakness (HP:0003749)1.66291150
71Hypoplastic pelvis (HP:0008839)1.64876309
72Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.63081601
73Postnatal growth retardation (HP:0008897)1.62659351
74Abnormality of DNA repair (HP:0003254)1.59462971
75Abnormality of saccadic eye movements (HP:0000570)1.58177187
76Postural tremor (HP:0002174)1.56577989
77Abnormality of the pons (HP:0007361)1.55786498
78Long toe (HP:0010511)1.55713504
79Shoulder girdle muscle weakness (HP:0003547)1.55710345
80Neoplasm of the tracheobronchial system (HP:0100552)1.55112632
81Subacute progressive viral hepatitis (HP:0006572)1.53013561
82Hematochezia (HP:0002573)1.52617313
83Generalized hypopigmentation of hair (HP:0011358)1.50538148
84Death in childhood (HP:0003819)1.49083896
85Tracheoesophageal fistula (HP:0002575)1.48663318
86Limb-girdle muscle atrophy (HP:0003797)1.46528977
87Abnormality of the sella turcica (HP:0002679)1.45989866
88Decreased circulating renin level (HP:0003351)1.43593593
89Preauricular pit (HP:0004467)1.43206573
90Periauricular skin pits (HP:0100277)1.43206573
91Rectal prolapse (HP:0002035)1.43152932
92Abnormality of the preputium (HP:0100587)1.42448287
93Short nail (HP:0001799)1.37100620
94Thickened calvaria (HP:0002684)1.36923885
95Conjunctival hamartoma (HP:0100780)1.36848043
96Small hand (HP:0200055)1.36685778
97Skin pits (HP:0100276)1.36578187
98Osteoporosis (HP:0000939)1.36065787
99Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.35438348
100Short 4th metacarpal (HP:0010044)1.35438348

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK9.97199464
2IRAK36.72812991
3TLK14.34006630
4MAP2K73.91089989
5MAP3K43.87929778
6ZAK3.48762097
7MAP2K42.61487060
8PKN22.53524476
9CAMK1D2.17863744
10STK241.99779930
11CAMKK21.77158799
12CAMK1G1.57789499
13FLT31.35046782
14NEK91.34182319
15STK38L1.17938642
16VRK11.17091856
17RET1.13143786
18MAP3K21.06203148
19TGFBR21.01724903
20STK40.92883704
21MAP3K60.90992503
22CAMK40.90125034
23SYK0.82845347
24CSK0.81312607
25GRK70.77050961
26TRPM70.74373029
27KSR20.66594273
28SGK20.64628085
29PLK20.62767824
30PKN10.62433564
31PIM10.61231249
32RPS6KA50.61072993
33SGK30.60866202
34MAP3K50.59767164
35WNK10.55022724
36CDK90.54767042
37AKT30.54287816
38STK30.52116678
39TAF10.49918453
40LYN0.49606976
41FGFR10.47756882
42DAPK30.46759845
43ADRBK20.45445660
44MOS0.45356376
45PRKCI0.43048326
46CSNK1A1L0.40301715
47GRK10.40096874
48TNIK0.39370964
49MAP3K90.39236887
50RPS6KA20.37834559
51PIK3CG0.37150946
52SCYL20.36950804
53ERBB40.36856758
54MAP3K80.35748791
55MAP2K30.35360346
56SGK4940.35341386
57SGK2230.35341386
58BMPR20.35100409
59PRKAA10.34712157
60AURKA0.33149667
61PDGFRB0.32801552
62RPS6KA60.32655267
63KSR10.31822005
64MAP3K140.30559891
65PDK10.30053329
66JAK20.30009336
67ZAP700.29528508
68EGFR0.29109091
69EEF2K0.29092182
70RPS6KC10.28400627
71RPS6KL10.28400627
72OBSCN0.27660845
73TAOK30.27227655
74AKT20.26462538
75MKNK20.25889573
76MELK0.23020334
77MAPK110.22707759
78DAPK20.21864074
79MAPK40.20321483
80FGFR30.19825131
81CAMKK10.19234846
82CSNK1G30.18864711
83INSR0.17975489
84PDPK10.17888560
85RAF10.17638707
86FYN0.16911160
87RPS6KB10.15101457
88RIPK40.14966972
89ERBB20.14822690
90PRKAA20.14322834
91HIPK20.14049810
92EIF2AK30.13104579
93CAMK10.11877510
94LATS10.10930172
95CSNK1G20.10845506
96CSNK1G10.10115023
97CDK60.10063238
98IGF1R0.09213071
99ABL20.08891814
100CAMK2A0.08696931

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053225.68769668
2Sulfur metabolism_Homo sapiens_hsa009204.03490931
3Alcoholism_Homo sapiens_hsa050343.58625328
4Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.15545626
5Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.12276743
6Viral carcinogenesis_Homo sapiens_hsa052031.80922853
7Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.79647293
8GnRH signaling pathway_Homo sapiens_hsa049121.70052311
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.65824989
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63098088
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.56763372
12Staphylococcus aureus infection_Homo sapiens_hsa051501.56704119
13Platelet activation_Homo sapiens_hsa046111.49490351
14Ovarian steroidogenesis_Homo sapiens_hsa049131.48705864
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.45403158
16Leishmaniasis_Homo sapiens_hsa051401.45213879
17Dilated cardiomyopathy_Homo sapiens_hsa054141.43233297
18Selenocompound metabolism_Homo sapiens_hsa004501.35382434
19Bladder cancer_Homo sapiens_hsa052191.31787436
20Dorso-ventral axis formation_Homo sapiens_hsa043201.31715966
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30416925
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.30131153
23Longevity regulating pathway - mammal_Homo sapiens_hsa042111.25045520
24Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23854361
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23836435
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23482163
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21935301
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19416611
29Gap junction_Homo sapiens_hsa045401.19383839
30Osteoclast differentiation_Homo sapiens_hsa043801.16018485
31TNF signaling pathway_Homo sapiens_hsa046681.12017642
32Fatty acid biosynthesis_Homo sapiens_hsa000611.11011671
33Chemokine signaling pathway_Homo sapiens_hsa040621.09521703
34Type II diabetes mellitus_Homo sapiens_hsa049301.06291041
35Insulin secretion_Homo sapiens_hsa049111.05695580
36Morphine addiction_Homo sapiens_hsa050321.05639547
37Estrogen signaling pathway_Homo sapiens_hsa049151.01223743
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98765353
39Neurotrophin signaling pathway_Homo sapiens_hsa047220.93524488
40Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92593825
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92555003
42mTOR signaling pathway_Homo sapiens_hsa041500.92107406
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91012629
44Thyroid hormone synthesis_Homo sapiens_hsa049180.90618687
45Gastric acid secretion_Homo sapiens_hsa049710.90275194
46Cholinergic synapse_Homo sapiens_hsa047250.89414943
47cAMP signaling pathway_Homo sapiens_hsa040240.89244402
48Tuberculosis_Homo sapiens_hsa051520.84100562
49Other glycan degradation_Homo sapiens_hsa005110.82538681
50Prolactin signaling pathway_Homo sapiens_hsa049170.81739896
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81252197
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79978524
53Glutamatergic synapse_Homo sapiens_hsa047240.78874396
54Pancreatic cancer_Homo sapiens_hsa052120.78244510
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77283277
56Salivary secretion_Homo sapiens_hsa049700.76374267
57Bile secretion_Homo sapiens_hsa049760.75966985
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75893565
59Melanogenesis_Homo sapiens_hsa049160.74907940
60Amoebiasis_Homo sapiens_hsa051460.74782511
61GABAergic synapse_Homo sapiens_hsa047270.74117076
62ErbB signaling pathway_Homo sapiens_hsa040120.74008872
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.70949753
64Circadian entrainment_Homo sapiens_hsa047130.70571578
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70103210
66PPAR signaling pathway_Homo sapiens_hsa033200.70089641
67Pancreatic secretion_Homo sapiens_hsa049720.69616207
68Oxytocin signaling pathway_Homo sapiens_hsa049210.68512813
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.66990250
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.65644970
71Influenza A_Homo sapiens_hsa051640.65302521
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.64109701
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63658706
74Vibrio cholerae infection_Homo sapiens_hsa051100.63589442
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.62842296
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61469772
77Insulin resistance_Homo sapiens_hsa049310.61421883
78Taste transduction_Homo sapiens_hsa047420.61301147
79Melanoma_Homo sapiens_hsa052180.60635837
80Olfactory transduction_Homo sapiens_hsa047400.59912656
81MAPK signaling pathway_Homo sapiens_hsa040100.58663828
82B cell receptor signaling pathway_Homo sapiens_hsa046620.58386431
83Calcium signaling pathway_Homo sapiens_hsa040200.57056350
84TGF-beta signaling pathway_Homo sapiens_hsa043500.52304529
85Oocyte meiosis_Homo sapiens_hsa041140.51437579
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.50176635
87FoxO signaling pathway_Homo sapiens_hsa040680.50139401
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.50058830
89Hepatitis B_Homo sapiens_hsa051610.45899817
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45083031
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44418449
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43463018
93Complement and coagulation cascades_Homo sapiens_hsa046100.42056593
94Apoptosis_Homo sapiens_hsa042100.41925779
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41748914
96Rap1 signaling pathway_Homo sapiens_hsa040150.38934962
97Choline metabolism in cancer_Homo sapiens_hsa052310.38859618
98Acute myeloid leukemia_Homo sapiens_hsa052210.37416576
99T cell receptor signaling pathway_Homo sapiens_hsa046600.35416257
100Renin-angiotensin system_Homo sapiens_hsa046140.35036987

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