ZBED8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX biosynthetic process (GO:0006782)5.02280068
2centriole replication (GO:0007099)4.83800438
3behavioral response to nicotine (GO:0035095)4.43309972
4nonmotile primary cilium assembly (GO:0035058)4.19450338
5G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.00861823
6N-acetylneuraminate metabolic process (GO:0006054)3.99761507
7pyrimidine nucleobase catabolic process (GO:0006208)3.98512905
8presynaptic membrane assembly (GO:0097105)3.88718051
9intraciliary transport (GO:0042073)3.88542209
10protoporphyrinogen IX metabolic process (GO:0046501)3.74265311
11N-acetylglucosamine metabolic process (GO:0006044)3.62311379
12thalamus development (GO:0021794)3.58036591
13RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.53387181
14tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.53387181
15epithelial cilium movement (GO:0003351)3.41153234
16protein localization to cilium (GO:0061512)3.40302512
17base-excision repair, AP site formation (GO:0006285)3.38203600
18nucleobase catabolic process (GO:0046113)3.34150862
19postsynaptic membrane organization (GO:0001941)3.31665885
20protein deneddylation (GO:0000338)3.31293430
21dendritic spine morphogenesis (GO:0060997)3.30496046
22regulation of cilium movement (GO:0003352)3.28195510
23presynaptic membrane organization (GO:0097090)3.22549743
24positive regulation of mitochondrial fission (GO:0090141)3.21968236
25regulation of synapse structural plasticity (GO:0051823)3.21501013
26gamma-aminobutyric acid transport (GO:0015812)3.15411082
27prostate gland growth (GO:0060736)3.14425707
28deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.13768896
29centriole assembly (GO:0098534)3.07623425
30DNA double-strand break processing (GO:0000729)3.02418854
31short-term memory (GO:0007614)2.99583306
32calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.84127830
33response to misfolded protein (GO:0051788)2.84095249
34negative regulation of oligodendrocyte differentiation (GO:0048715)2.83339198
35neuron cell-cell adhesion (GO:0007158)2.82905216
36positive regulation of oligodendrocyte differentiation (GO:0048714)2.81934433
37negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.80694260
38olfactory bulb development (GO:0021772)2.80212117
39regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.76402529
40regulation of MHC class II biosynthetic process (GO:0045346)2.75436243
41pyrimidine dimer repair (GO:0006290)2.73960890
42peptidyl-histidine modification (GO:0018202)2.71615429
43cilium organization (GO:0044782)2.70790225
44response to pheromone (GO:0019236)2.69801513
45cilium assembly (GO:0042384)2.68802982
46regulation of hexokinase activity (GO:1903299)2.68779175
47regulation of glucokinase activity (GO:0033131)2.68779175
48retinal ganglion cell axon guidance (GO:0031290)2.67017517
49positive regulation of histone deacetylation (GO:0031065)2.66875148
50cilium movement (GO:0003341)2.62711425
51regulation of helicase activity (GO:0051095)2.61794761
52vocalization behavior (GO:0071625)2.61298988
53synapse assembly (GO:0007416)2.61003834
54regulation of oligodendrocyte differentiation (GO:0048713)2.59332765
55neuronal action potential propagation (GO:0019227)2.59235122
56limb bud formation (GO:0060174)2.58013364
57transmission of nerve impulse (GO:0019226)2.57195031
58synaptic transmission, cholinergic (GO:0007271)2.56806633
59cilium morphogenesis (GO:0060271)2.55002475
60regulation of feeding behavior (GO:0060259)2.52351365
61glutamate receptor signaling pathway (GO:0007215)2.51473601
62regulation of neurotransmitter uptake (GO:0051580)2.49860379
63insulin-like growth factor receptor signaling pathway (GO:0048009)2.48647400
64DNA integration (GO:0015074)2.48523779
65regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.47957576
66misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.47382332
67regulation of glycolytic process (GO:0006110)2.47347870
68somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.44871819
69isotype switching (GO:0045190)2.44871819
70somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.44871819
71regulation of coenzyme metabolic process (GO:0051196)2.44830060
72regulation of cofactor metabolic process (GO:0051193)2.44830060
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.44737365
74cullin deneddylation (GO:0010388)2.43788521
75response to folic acid (GO:0051593)2.43023810
76axonal fasciculation (GO:0007413)2.36987093
77cerebral cortex radially oriented cell migration (GO:0021799)2.36687024
78regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.36452149
79regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.36452149
80preassembly of GPI anchor in ER membrane (GO:0016254)2.36251034
81water-soluble vitamin biosynthetic process (GO:0042364)2.35354229
82ventricular system development (GO:0021591)2.34386754
83regulation of acyl-CoA biosynthetic process (GO:0050812)2.33011603
84retinal cone cell development (GO:0046549)2.32758981
85purine deoxyribonucleotide catabolic process (GO:0009155)2.30641279
86regulation of development, heterochronic (GO:0040034)2.29867597
87cytokinetic process (GO:0032506)2.29723402
88smoothened signaling pathway (GO:0007224)2.29607230
89mannosylation (GO:0097502)2.29401215
90negative regulation of transcription regulatory region DNA binding (GO:2000678)2.29041007
91auditory behavior (GO:0031223)2.25882566
92establishment of melanosome localization (GO:0032401)2.24377873
93positive regulation of dendritic spine development (GO:0060999)2.24181172
94glucosamine-containing compound metabolic process (GO:1901071)2.22104599
95mechanosensory behavior (GO:0007638)2.20798257
96neurotransmitter-gated ion channel clustering (GO:0072578)2.20468461
97positive regulation of synapse assembly (GO:0051965)2.20141273
98cornea development in camera-type eye (GO:0061303)2.19764656
99L-fucose catabolic process (GO:0042355)2.19194378
100L-fucose metabolic process (GO:0042354)2.19194378

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human4.12131737
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.73021538
3ZNF274_21170338_ChIP-Seq_K562_Hela3.20997943
4GBX2_23144817_ChIP-Seq_PC3_Human3.19303578
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.99319261
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.85728289
7VDR_22108803_ChIP-Seq_LS180_Human2.74523483
8EZH2_22144423_ChIP-Seq_EOC_Human2.73658099
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.65555018
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.60345477
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.60266822
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.57632364
13FUS_26573619_Chip-Seq_HEK293_Human2.36510133
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25738204
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.18279928
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.17137919
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06266716
18IRF1_19129219_ChIP-ChIP_H3396_Human2.04908324
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01616411
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98082306
21EWS_26573619_Chip-Seq_HEK293_Human1.96445766
22TAF15_26573619_Chip-Seq_HEK293_Human1.94676919
23P300_19829295_ChIP-Seq_ESCs_Human1.89936376
24ELK1_19687146_ChIP-ChIP_HELA_Human1.87634104
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.87452739
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62946914
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.60871821
28ER_23166858_ChIP-Seq_MCF-7_Human1.59468030
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57191118
30MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55339268
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49978441
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.49828199
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47926070
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.47268532
35RNF2_27304074_Chip-Seq_NSC_Mouse1.46526259
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45195431
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.45157344
38SMAD4_21799915_ChIP-Seq_A2780_Human1.44129716
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42213119
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38934575
41MYC_18940864_ChIP-ChIP_HL60_Human1.34659568
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34242424
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.33817609
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31661435
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29624005
46KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28292119
47FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.26576773
48CBP_20019798_ChIP-Seq_JUKART_Human1.25872512
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25872512
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25779906
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25659434
52STAT3_23295773_ChIP-Seq_U87_Human1.24589891
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22650140
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22550063
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.22405726
56NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18944742
57RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18600783
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17914805
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17597840
60BCAT_22108803_ChIP-Seq_LS180_Human1.16583223
61REST_21632747_ChIP-Seq_MESCs_Mouse1.16178835
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15340232
63AR_25329375_ChIP-Seq_VCAP_Human1.14505909
64CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14363378
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12152540
66REST_18959480_ChIP-ChIP_MESCs_Mouse1.11653683
67TP53_22573176_ChIP-Seq_HFKS_Human1.11598335
68E2F4_17652178_ChIP-ChIP_JURKAT_Human1.09645270
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09186603
70TCF4_23295773_ChIP-Seq_U87_Human1.08980085
71SOX2_19829295_ChIP-Seq_ESCs_Human1.08752556
72NANOG_19829295_ChIP-Seq_ESCs_Human1.08752556
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07877861
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07823700
75VDR_23849224_ChIP-Seq_CD4+_Human1.07770026
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05910560
77MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05871339
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.04593512
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04241361
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03938063
81AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03228805
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03018577
83ETS1_20019798_ChIP-Seq_JURKAT_Human1.02610982
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01876342
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97214362
86P53_22387025_ChIP-Seq_ESCs_Mouse0.96912368
87JUN_21703547_ChIP-Seq_K562_Human0.96811764
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96537499
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96537499
90SOX9_26525672_Chip-Seq_HEART_Mouse0.96526599
91IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95808851
92AR_21572438_ChIP-Seq_LNCaP_Human0.95592484
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95190513
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95180760
95RUNX2_22187159_ChIP-Seq_PCA_Human0.94710726
96EZH2_27294783_Chip-Seq_NPCs_Mouse0.93488601
97SRF_21415370_ChIP-Seq_HL-1_Mouse0.92521292
98FLI1_21867929_ChIP-Seq_TH2_Mouse0.92444595
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91688398
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90852545

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract3.88253190
2MP0001529_abnormal_vocalization3.01910726
3MP0001984_abnormal_olfaction2.58126854
4MP0008058_abnormal_DNA_repair2.35672761
5MP0004043_abnormal_pH_regulation2.27266441
6MP0003122_maternal_imprinting2.12700422
7MP0003121_genomic_imprinting2.02319752
8MP0008789_abnormal_olfactory_epithelium1.99148067
9MP0005499_abnormal_olfactory_system1.95948576
10MP0005394_taste/olfaction_phenotype1.95948576
11MP0002653_abnormal_ependyma_morphology1.92670203
12MP0003880_abnormal_central_pattern1.90003520
13MP0008961_abnormal_basal_metabolism1.83187735
14MP0002102_abnormal_ear_morphology1.81201237
15MP0004885_abnormal_endolymph1.80700482
16MP0000569_abnormal_digit_pigmentation1.78627406
17MP0009745_abnormal_behavioral_response1.74439302
18MP0000778_abnormal_nervous_system1.73380747
19MP0004142_abnormal_muscle_tone1.72394356
20MP0006276_abnormal_autonomic_nervous1.68781916
21MP0006292_abnormal_olfactory_placode1.68718728
22MP0008877_abnormal_DNA_methylation1.67016927
23MP0005551_abnormal_eye_electrophysiolog1.66845494
24MP0002638_abnormal_pupillary_reflex1.66306962
25MP0009046_muscle_twitch1.66003643
26MP0002822_catalepsy1.61732111
27MP0006072_abnormal_retinal_apoptosis1.59557102
28MP0002272_abnormal_nervous_system1.57018866
29MP0002234_abnormal_pharynx_morphology1.54072320
30MP0003136_yellow_coat_color1.50124967
31MP0003123_paternal_imprinting1.48292351
32MP0002736_abnormal_nociception_after1.47374667
33MP0004270_analgesia1.46774146
34MP0004133_heterotaxia1.44665132
35MP0005253_abnormal_eye_physiology1.42680438
36MP0001968_abnormal_touch/_nociception1.40357363
37MP0002938_white_spotting1.38834662
38MP0000955_abnormal_spinal_cord1.38246821
39MP0003787_abnormal_imprinting1.36936417
40MP0002572_abnormal_emotion/affect_behav1.36701817
41MP0002063_abnormal_learning/memory/cond1.32915926
42MP0004859_abnormal_synaptic_plasticity1.31556383
43MP0002909_abnormal_adrenal_gland1.31240452
44MP0003635_abnormal_synaptic_transmissio1.30954725
45MP0002184_abnormal_innervation1.27998822
46MP0001486_abnormal_startle_reflex1.24437346
47MP0002837_dystrophic_cardiac_calcinosis1.21688064
48MP0005365_abnormal_bile_salt1.20618701
49MP0002734_abnormal_mechanical_nocicepti1.20360948
50MP0005645_abnormal_hypothalamus_physiol1.19945142
51MP0002751_abnormal_autonomic_nervous1.16167713
52MP0002557_abnormal_social/conspecific_i1.15810553
53MP0000516_abnormal_urinary_system1.15463123
54MP0005367_renal/urinary_system_phenotyp1.15463123
55MP0001502_abnormal_circadian_rhythm1.15018080
56MP0005171_absent_coat_pigmentation1.14347992
57MP0008872_abnormal_physiological_respon1.12876256
58MP0003119_abnormal_digestive_system1.11971525
59MP0000049_abnormal_middle_ear1.11721355
60MP0001177_atelectasis1.11602136
61MP0001970_abnormal_pain_threshold1.11552322
62MP0002064_seizures1.09425650
63MP0002882_abnormal_neuron_morphology1.06528621
64MP0001324_abnormal_eye_pigmentation1.04291353
65MP0002735_abnormal_chemical_nociception1.04222103
66MP0003011_delayed_dark_adaptation1.04161216
67MP0001986_abnormal_taste_sensitivity1.03956486
68MP0005670_abnormal_white_adipose1.03655531
69MP0002752_abnormal_somatic_nervous1.02990601
70MP0005085_abnormal_gallbladder_physiolo1.01624067
71MP0005248_abnormal_Harderian_gland1.01158948
72MP0003937_abnormal_limbs/digits/tail_de1.00957351
73MP0001293_anophthalmia1.00890999
74MP0000631_abnormal_neuroendocrine_gland1.00851619
75MP0003195_calcinosis1.00326255
76MP0002233_abnormal_nose_morphology1.00210243
77MP0003252_abnormal_bile_duct0.99305618
78MP0002067_abnormal_sensory_capabilities0.98563710
79MP0003221_abnormal_cardiomyocyte_apopto0.97956032
80MP0004742_abnormal_vestibular_system0.96569875
81MP0000026_abnormal_inner_ear0.96564236
82MP0003567_abnormal_fetal_cardiomyocyte0.94585488
83MP0000372_irregular_coat_pigmentation0.93286794
84MP0003938_abnormal_ear_development0.92070796
85MP0005084_abnormal_gallbladder_morpholo0.91568495
86MP0008995_early_reproductive_senescence0.90786457
87MP0000427_abnormal_hair_cycle0.89971662
88MP0005386_behavior/neurological_phenoty0.89440402
89MP0004924_abnormal_behavior0.89440402
90MP0002733_abnormal_thermal_nociception0.88703626
91MP0005187_abnormal_penis_morphology0.87985384
92MP0004811_abnormal_neuron_physiology0.87072313
93MP0003786_premature_aging0.85898383
94MP0008057_abnormal_DNA_replication0.85226707
95MP0005195_abnormal_posterior_eye0.84590034
96MP0002090_abnormal_vision0.83607554
97MP0002152_abnormal_brain_morphology0.83224756
98MP0003861_abnormal_nervous_system0.81732725
99MP0000647_abnormal_sebaceous_gland0.79256747
100MP0005423_abnormal_somatic_nervous0.78567953

Predicted human phenotypes

RankGene SetZ-score
1Medial flaring of the eyebrow (HP:0010747)3.96592616
2Gait imbalance (HP:0002141)3.82528024
3Congenital primary aphakia (HP:0007707)3.68181842
4Nephrogenic diabetes insipidus (HP:0009806)3.34084559
5Genital tract atresia (HP:0001827)3.18458366
6Vaginal atresia (HP:0000148)3.17050502
7Hyperglycinemia (HP:0002154)3.10634824
8Tubulointerstitial nephritis (HP:0001970)3.08430466
9Drooling (HP:0002307)3.04362769
10Hepatoblastoma (HP:0002884)2.88111974
11True hermaphroditism (HP:0010459)2.85167423
12Nephronophthisis (HP:0000090)2.78905316
13Lissencephaly (HP:0001339)2.71709598
14Excessive salivation (HP:0003781)2.70405353
15Lipid accumulation in hepatocytes (HP:0006561)2.66021294
16Poor coordination (HP:0002370)2.63451171
17Pancreatic fibrosis (HP:0100732)2.57891884
18Increased hepatocellular lipid droplets (HP:0006565)2.56251220
19Pancreatic cysts (HP:0001737)2.52956378
20Abnormality of the labia minora (HP:0012880)2.50950357
21Abnormality of the renal medulla (HP:0100957)2.50881166
22Postaxial hand polydactyly (HP:0001162)2.50732186
23Broad foot (HP:0001769)2.49587668
24Abnormality of the metopic suture (HP:0005556)2.45406976
25Methylmalonic acidemia (HP:0002912)2.36343747
26Postaxial foot polydactyly (HP:0001830)2.34784286
27Retinal dysplasia (HP:0007973)2.33577120
28Pachygyria (HP:0001302)2.30083090
29Ketoacidosis (HP:0001993)2.27980460
30Type II lissencephaly (HP:0007260)2.27409453
31Broad-based gait (HP:0002136)2.27351742
32Sclerocornea (HP:0000647)2.22108462
33Hypoplastic pelvis (HP:0008839)2.22042072
34Neoplasm of the adrenal cortex (HP:0100641)2.20470555
35Rib fusion (HP:0000902)2.18216022
36Absent speech (HP:0001344)2.17176558
37Aplasia/Hypoplasia of the lens (HP:0008063)2.16182783
38Decreased testicular size (HP:0008734)2.12548697
39Failure to thrive in infancy (HP:0001531)2.11307929
40Specific learning disability (HP:0001328)2.11007827
41Abnormality of the renal cortex (HP:0011035)2.10419785
42Progressive cerebellar ataxia (HP:0002073)2.09647412
43Colon cancer (HP:0003003)2.09255324
44Progressive inability to walk (HP:0002505)2.08894146
45Cortical dysplasia (HP:0002539)2.06036797
46Hemiparesis (HP:0001269)2.04727363
47Septo-optic dysplasia (HP:0100842)2.04640227
48Renal Fanconi syndrome (HP:0001994)2.03382939
49Long clavicles (HP:0000890)2.03217861
50Increased serum pyruvate (HP:0003542)2.02933471
51Prominent metopic ridge (HP:0005487)2.01559505
52Limb dystonia (HP:0002451)2.00786836
53Short foot (HP:0001773)1.97378850
54Polyphagia (HP:0002591)1.97159971
55Partial agenesis of the corpus callosum (HP:0001338)1.96921722
56Occipital encephalocele (HP:0002085)1.96674865
57Optic nerve hypoplasia (HP:0000609)1.96473548
58Renal cortical cysts (HP:0000803)1.95898171
59Hyperventilation (HP:0002883)1.95697378
60Tubulointerstitial abnormality (HP:0001969)1.95453143
61Abnormality of glycolysis (HP:0004366)1.95165743
62Intestinal atresia (HP:0011100)1.94996333
63Abnormality of midbrain morphology (HP:0002418)1.93621088
64Molar tooth sign on MRI (HP:0002419)1.93621088
65Aplasia/Hypoplasia of the brainstem (HP:0007362)1.92194950
66Hypoplasia of the brainstem (HP:0002365)1.92194950
67Meckel diverticulum (HP:0002245)1.91694009
68Hypsarrhythmia (HP:0002521)1.91565438
69Acute encephalopathy (HP:0006846)1.89031721
70Epidermoid cyst (HP:0200040)1.85513433
71Progressive microcephaly (HP:0000253)1.83983961
72Abnormality of the ileum (HP:0001549)1.82343611
73EEG with generalized epileptiform discharges (HP:0011198)1.80497623
74Aplasia/Hypoplasia of the tongue (HP:0010295)1.80065315
75Astigmatism (HP:0000483)1.80061061
76Febrile seizures (HP:0002373)1.79219021
77Epileptiform EEG discharges (HP:0011182)1.78489511
78Acute necrotizing encephalopathy (HP:0006965)1.77204186
79Inability to walk (HP:0002540)1.76479814
80Poor suck (HP:0002033)1.75743281
81Anencephaly (HP:0002323)1.73890107
82Aplasia/Hypoplasia of the uvula (HP:0010293)1.73729372
83Preaxial hand polydactyly (HP:0001177)1.73683469
84Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73561401
85Micropenis (HP:0000054)1.72152940
86Focal motor seizures (HP:0011153)1.71564064
87Delayed CNS myelination (HP:0002188)1.70484709
88Congenital hepatic fibrosis (HP:0002612)1.70236954
89Aganglionic megacolon (HP:0002251)1.68223792
90Delayed gross motor development (HP:0002194)1.66148700
91Methylmalonic aciduria (HP:0012120)1.66016900
92Anterior segment dysgenesis (HP:0007700)1.65213018
93Neoplasm of the adrenal gland (HP:0100631)1.64242084
94Mitochondrial inheritance (HP:0001427)1.64185686
95Aplasia/hypoplasia of the uterus (HP:0008684)1.63083803
96Aplasia/Hypoplasia of the tibia (HP:0005772)1.61762287
97Spastic tetraplegia (HP:0002510)1.60477467
98Multicystic kidney dysplasia (HP:0000003)1.60140811
99Retinal atrophy (HP:0001105)1.59898248
100Polymicrogyria (HP:0002126)1.59890166

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CCNB15.03046940
2NEK23.77741659
3WNK33.20461065
4CAMKK22.98515055
5MAP3K42.90443994
6BCR2.88600649
7MAP2K72.57185276
8MARK12.51663383
9CASK2.33347494
10FRK2.11142008
11TRIM282.09619110
12WNK42.06529850
13MAP4K21.99507068
14VRK21.94951164
15SRPK11.94334288
16CSNK1G31.79789532
17MAPK131.73318149
18CSNK1G11.69951837
19CSNK1G21.65095220
20CSNK1A1L1.60115071
21DYRK21.58655878
22CAMK1D1.54499131
23TAF11.54333602
24ERBB31.53590243
25NUAK11.49387427
26VRK11.37758311
27PLK21.34087176
28WEE11.31601441
29PAK31.29028706
30EPHA31.27497749
31PLK31.24786026
32RPS6KA41.15463462
33EPHA41.07615814
34MKNK11.04959852
35ADRBK21.04948314
36PBK1.04083307
37TSSK61.03302272
38BCKDK1.03127246
39STK161.02915454
40CAMK1G1.02275959
41DYRK31.00514547
42PNCK1.00351930
43MKNK20.95572860
44PRKCG0.95393461
45PRKCE0.94745969
46INSRR0.93296010
47CAMK10.89271441
48LIMK10.87550396
49ZAK0.87183587
50NTRK20.84621792
51PINK10.81537201
52NTRK30.80799454
53GRK10.80731120
54CAMK40.80265070
55MAP2K40.79027963
56BMPR1B0.78428667
57PRKD30.78054309
58BRSK20.75108878
59MAP3K70.72193195
60MAPK150.70227247
61STK390.68857217
62CAMKK10.64194363
63DYRK1A0.62746881
64FGFR20.60916091
65MAPKAPK50.59928638
66NEK10.59840103
67CAMK2B0.57827988
68CHUK0.55086003
69SGK4940.52273521
70SGK2230.52273521
71GRK70.52149515
72CDC70.51665888
73PIK3CA0.51287015
74EIF2AK10.51251914
75TNIK0.50121016
76PLK40.49635215
77CSNK1A10.49389048
78UHMK10.49093128
79PLK10.48168355
80EIF2AK20.46633968
81CSNK1D0.46549231
82MINK10.45947092
83EIF2AK30.45853827
84BUB10.45458471
85CDK140.44815286
86RPS6KA50.43997039
87CAMK2A0.43669266
88STK38L0.42732097
89GRK50.42440723
90EPHB20.42102367
91KSR10.41175439
92TESK10.40685922
93AKT30.39845386
94CAMK2D0.39832997
95SGK20.39146167
96PRKAA10.38542407
97PKN10.37547775
98OBSCN0.36649766
99CDK180.36248660
100PASK0.35471596

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.66400502
2Protein export_Homo sapiens_hsa030602.39638588
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.39006843
4Propanoate metabolism_Homo sapiens_hsa006402.34424213
5Oxidative phosphorylation_Homo sapiens_hsa001902.04452986
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.03775403
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.03128412
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.94269213
9Basal transcription factors_Homo sapiens_hsa030221.93129712
10Vitamin B6 metabolism_Homo sapiens_hsa007501.91246047
11Butanoate metabolism_Homo sapiens_hsa006501.91146408
12Maturity onset diabetes of the young_Homo sapiens_hsa049501.88777944
13Fanconi anemia pathway_Homo sapiens_hsa034601.87814827
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.72246692
15Steroid biosynthesis_Homo sapiens_hsa001001.68506726
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66022137
17Mismatch repair_Homo sapiens_hsa034301.61131708
18Pyruvate metabolism_Homo sapiens_hsa006201.57603021
19Fatty acid elongation_Homo sapiens_hsa000621.57200889
20Parkinsons disease_Homo sapiens_hsa050121.56411154
21Phototransduction_Homo sapiens_hsa047441.52605719
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49810908
23GABAergic synapse_Homo sapiens_hsa047271.45645898
24Homologous recombination_Homo sapiens_hsa034401.37167812
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.34289238
26Base excision repair_Homo sapiens_hsa034101.33042871
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30445774
28Synaptic vesicle cycle_Homo sapiens_hsa047211.28887168
29Selenocompound metabolism_Homo sapiens_hsa004501.28482815
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27548153
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.27252177
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25787569
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21109659
34Nucleotide excision repair_Homo sapiens_hsa034201.19173010
35Hedgehog signaling pathway_Homo sapiens_hsa043401.18066322
36Non-homologous end-joining_Homo sapiens_hsa034501.16532542
37Glutamatergic synapse_Homo sapiens_hsa047241.15769936
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11867193
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08336102
40Circadian entrainment_Homo sapiens_hsa047131.07483607
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03852893
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03467821
43Axon guidance_Homo sapiens_hsa043601.03414834
44Morphine addiction_Homo sapiens_hsa050321.03280973
45DNA replication_Homo sapiens_hsa030301.01790758
46Huntingtons disease_Homo sapiens_hsa050161.00057385
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99755793
48Peroxisome_Homo sapiens_hsa041460.99068180
49Collecting duct acid secretion_Homo sapiens_hsa049660.98142741
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97254349
51Taste transduction_Homo sapiens_hsa047420.92008458
52Basal cell carcinoma_Homo sapiens_hsa052170.91591917
53beta-Alanine metabolism_Homo sapiens_hsa004100.91552035
54Cardiac muscle contraction_Homo sapiens_hsa042600.91515539
55Glutathione metabolism_Homo sapiens_hsa004800.89722759
56Ether lipid metabolism_Homo sapiens_hsa005650.88942579
57Dopaminergic synapse_Homo sapiens_hsa047280.87945121
58RNA polymerase_Homo sapiens_hsa030200.86285366
59RNA degradation_Homo sapiens_hsa030180.85311422
60Oocyte meiosis_Homo sapiens_hsa041140.82780498
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.82737682
62Alzheimers disease_Homo sapiens_hsa050100.82135176
63Vibrio cholerae infection_Homo sapiens_hsa051100.81884134
64Regulation of autophagy_Homo sapiens_hsa041400.80157335
65Folate biosynthesis_Homo sapiens_hsa007900.79486767
66Fatty acid metabolism_Homo sapiens_hsa012120.79111657
67Circadian rhythm_Homo sapiens_hsa047100.76750361
68Renin-angiotensin system_Homo sapiens_hsa046140.75598796
69Cocaine addiction_Homo sapiens_hsa050300.73225172
70Linoleic acid metabolism_Homo sapiens_hsa005910.70098956
71Metabolic pathways_Homo sapiens_hsa011000.69749889
72Tryptophan metabolism_Homo sapiens_hsa003800.69657755
73Caffeine metabolism_Homo sapiens_hsa002320.68326921
74Alcoholism_Homo sapiens_hsa050340.65999352
75Sulfur metabolism_Homo sapiens_hsa009200.65043478
76Insulin secretion_Homo sapiens_hsa049110.63806312
77Purine metabolism_Homo sapiens_hsa002300.62719574
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61163225
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59548074
80RNA transport_Homo sapiens_hsa030130.59066291
81Amphetamine addiction_Homo sapiens_hsa050310.57991813
82Pyrimidine metabolism_Homo sapiens_hsa002400.57808027
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57701965
84Spliceosome_Homo sapiens_hsa030400.56228364
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55370001
86Fatty acid degradation_Homo sapiens_hsa000710.54561739
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53669195
88Carbon metabolism_Homo sapiens_hsa012000.52937937
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52510452
90Long-term depression_Homo sapiens_hsa047300.50380412
91Lysine degradation_Homo sapiens_hsa003100.47684073
92Arginine and proline metabolism_Homo sapiens_hsa003300.47490139
93mRNA surveillance pathway_Homo sapiens_hsa030150.46393426
94Hippo signaling pathway_Homo sapiens_hsa043900.46358569
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.46338098
96Serotonergic synapse_Homo sapiens_hsa047260.46203721
97Chemical carcinogenesis_Homo sapiens_hsa052040.45836943
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45811083
99Nitrogen metabolism_Homo sapiens_hsa009100.45802376
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44806065

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