ZBED6CL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to lead ion (GO:0010288)9.28444257
2membrane repolarization during cardiac muscle cell action potential (GO:0086013)8.58577022
3response to lipoprotein particle (GO:0055094)8.40794455
4response to vitamin D (GO:0033280)7.81928653
5membrane repolarization during action potential (GO:0086011)7.48311801
6cellular response to vitamin D (GO:0071305)7.44824936
7trivalent inorganic anion homeostasis (GO:0072506)6.85872882
8phosphate ion homeostasis (GO:0055062)6.85872882
9response to hepatocyte growth factor (GO:0035728)6.74885708
10cellular response to hepatocyte growth factor stimulus (GO:0035729)6.74885708
11positive regulation of glycogen biosynthetic process (GO:0045725)6.37625969
12sodium ion export (GO:0071436)6.26375139
13negative regulation of erythrocyte differentiation (GO:0045647)6.22795712
14cellular anion homeostasis (GO:0030002)5.87283845
15cellular response to vitamin (GO:0071295)5.77517968
16cellular potassium ion homeostasis (GO:0030007)5.76337302
17positive regulation of glycogen metabolic process (GO:0070875)5.50572124
18regulation of glucose import in response to insulin stimulus (GO:2001273)5.38441162
19positive regulation of glucose import (GO:0046326)4.92242476
20regulation of apoptotic cell clearance (GO:2000425)4.70975045
21membrane repolarization (GO:0086009)4.64469506
22very-low-density lipoprotein particle assembly (GO:0034379)4.62556250
23bone resorption (GO:0045453)4.55203086
24regulation of complement activation (GO:0030449)4.44529187
25complement activation, alternative pathway (GO:0006957)4.41347223
26regulation of protein activation cascade (GO:2000257)4.26337814
27negative regulation of microtubule polymerization (GO:0031115)4.16512284
28regulation of histone H3-K27 methylation (GO:0061085)4.15055012
29positive regulation of glucose transport (GO:0010828)4.11366729
30negative regulation of smooth muscle cell differentiation (GO:0051151)4.09825820
31cellular sodium ion homeostasis (GO:0006883)4.05073657
32iron ion import (GO:0097286)3.99313946
33regulation of macrophage chemotaxis (GO:0010758)3.90208343
34CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.90026439
35cytoskeletal anchoring at plasma membrane (GO:0007016)3.86029043
36positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.71762400
37relaxation of cardiac muscle (GO:0055119)3.69606884
38regulation of early endosome to late endosome transport (GO:2000641)3.63617255
39positive regulation of cellular response to insulin stimulus (GO:1900078)3.62765142
40potassium ion homeostasis (GO:0055075)3.59367673
41regulation of glycogen biosynthetic process (GO:0005979)3.55790270
42regulation of glucan biosynthetic process (GO:0010962)3.55790270
43CD4-positive, alpha-beta T cell activation (GO:0035710)3.54836482
44bone morphogenesis (GO:0060349)3.52717355
45chemosensory behavior (GO:0007635)3.50919300
46response to ischemia (GO:0002931)3.48850153
47cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.45299350
48regulation of polysaccharide biosynthetic process (GO:0032885)3.39050425
49phosphatidylinositol dephosphorylation (GO:0046856)3.38370351
50detection of calcium ion (GO:0005513)3.36806057
51negative regulation of peptidyl-serine phosphorylation (GO:0033137)3.33858495
52positive regulation of Rap GTPase activity (GO:0032854)3.28500933
53thymus development (GO:0048538)3.27642825
54cellular response to nutrient (GO:0031670)3.26999724
55phospholipid dephosphorylation (GO:0046839)3.26613903
56myelin maintenance (GO:0043217)3.24504854
57positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.20038646
58plasma lipoprotein particle assembly (GO:0034377)3.14879927
59positive regulation of cellular amine metabolic process (GO:0033240)3.14223670
60modulation by symbiont of host cellular process (GO:0044068)3.13549575
61positive regulation of glucose metabolic process (GO:0010907)3.05679602
62regulation of translational fidelity (GO:0006450)3.03550827
63negative regulation of fatty acid biosynthetic process (GO:0045717)3.02807990
64NADH metabolic process (GO:0006734)3.01873345
65potassium ion import (GO:0010107)2.98790803
66regulation of cholesterol biosynthetic process (GO:0045540)2.94675298
67polyketide metabolic process (GO:0030638)2.93931014
68doxorubicin metabolic process (GO:0044598)2.93931014
69daunorubicin metabolic process (GO:0044597)2.93931014
70regulation of glycogen metabolic process (GO:0070873)2.92838331
71regulation of glucose import (GO:0046324)2.90795950
72regulation of cholesterol homeostasis (GO:2000188)2.90510579
73protein-lipid complex assembly (GO:0065005)2.89734721
74regulation of polysaccharide metabolic process (GO:0032881)2.87760698
75nuclear pore complex assembly (GO:0051292)2.86029594
76regulation of Golgi to plasma membrane protein transport (GO:0042996)2.84923274
77cell communication by electrical coupling (GO:0010644)2.80933937
78positive regulation of bone mineralization (GO:0030501)2.78893563
79activation of MAPKKK activity (GO:0000185)2.78808947
80positive regulation of biomineral tissue development (GO:0070169)2.78761787
81positive regulation of potassium ion transmembrane transport (GO:1901381)2.76447749
82protoporphyrinogen IX metabolic process (GO:0046501)2.73417265
83positive regulation of gamma-delta T cell activation (GO:0046645)2.70951124
84polyol biosynthetic process (GO:0046173)2.69898286
85neural tube formation (GO:0001841)2.66819931
86regulation of humoral immune response (GO:0002920)2.65720040
87C21-steroid hormone metabolic process (GO:0008207)2.64396244
88regulation of cholesterol metabolic process (GO:0090181)2.63416256
89embryonic process involved in female pregnancy (GO:0060136)2.61137831
90peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.59970876
91alpha-beta T cell differentiation (GO:0046632)2.58675180
92negative regulation of glycoprotein biosynthetic process (GO:0010561)2.55963017
93Rho protein signal transduction (GO:0007266)2.55487916
94oxaloacetate metabolic process (GO:0006107)2.54306161
95aminoglycoside antibiotic metabolic process (GO:0030647)2.54090362
96erythrocyte maturation (GO:0043249)2.53908056
97positive regulation of ATPase activity (GO:0032781)2.50929166
98positive regulation of ATP catabolic process (GO:1903291)2.50929166
99regulation of mononuclear cell migration (GO:0071675)2.50784559
100response to parathyroid hormone (GO:0071107)12.6769753

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.90194109
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.85796680
3MYC_22102868_ChIP-Seq_BL_Human2.79306345
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.63817261
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.45453510
6NCOR1_26117541_ChIP-Seq_K562_Human2.35958507
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.34447181
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.33653105
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.28403128
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.18459955
11VDR_21846776_ChIP-Seq_THP-1_Human2.07283402
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.03827969
13GATA1_19941826_ChIP-Seq_K562_Human1.93036947
14GATA1_22025678_ChIP-Seq_K562_Human1.86904461
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84531935
16RXR_22158963_ChIP-Seq_LIVER_Mouse1.81452274
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.78477630
18TFEB_21752829_ChIP-Seq_HELA_Human1.75681618
19TP63_17297297_ChIP-ChIP_HaCaT_Human1.74705992
20RACK7_27058665_Chip-Seq_MCF-7_Human1.72908768
21MYC_18555785_ChIP-Seq_MESCs_Mouse1.71918563
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.71655871
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70892029
24AR_21909140_ChIP-Seq_LNCAP_Human1.68979369
25LXR_22292898_ChIP-Seq_THP-1_Human1.67922262
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60034424
27GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.59760657
28PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.58389644
29KLF4_18555785_ChIP-Seq_MESCs_Mouse1.57028102
30PPARA_22158963_ChIP-Seq_LIVER_Mouse1.55850594
31MAF_26560356_Chip-Seq_TH1_Human1.55368753
32CIITA_25753668_ChIP-Seq_RAJI_Human1.53225338
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.52720978
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51417500
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50298722
36ZNF263_19887448_ChIP-Seq_K562_Human1.49921310
37TCF7_22412390_ChIP-Seq_EML_Mouse1.46714470
38ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43208399
39CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.42359528
40GATA1_22383799_ChIP-Seq_G1ME_Mouse1.40950971
41GATA2_19941826_ChIP-Seq_K562_Human1.38582517
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37736426
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36627513
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35847980
45SPI1_23127762_ChIP-Seq_K562_Human1.35682107
46CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.34408671
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34391007
48MYC_18358816_ChIP-ChIP_MESCs_Mouse1.33433026
49DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.31897058
50GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29907531
51UTX_26944678_Chip-Seq_JUKART_Human1.28542645
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26466098
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26404053
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25922670
55DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25754646
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25584545
57P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25211007
58SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.24475961
59TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23604933
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23208986
61XRN2_22483619_ChIP-Seq_HELA_Human1.22745284
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21950683
63MYC_19079543_ChIP-ChIP_MESCs_Mouse1.21836160
64NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20862690
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20755512
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.20350792
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.20129159
68SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19967609
69MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.19962067
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19833415
71MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19174853
72SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18961580
73KDM2B_26808549_Chip-Seq_DND41_Human1.18756247
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18524608
75CHD1_26751641_Chip-Seq_LNCaP_Human1.18396385
76DCP1A_22483619_ChIP-Seq_HELA_Human1.18095966
77NANOG_18555785_ChIP-Seq_MESCs_Mouse1.16559786
78CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16294912
79KDM2B_26808549_Chip-Seq_K562_Human1.16158124
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14554257
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11819851
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10557486
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08807539
84ATF3_27146783_Chip-Seq_COLON_Human1.08320753
85E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07921386
86CLOCK_20551151_ChIP-Seq_293T_Human1.07734817
87RUNX1_27514584_Chip-Seq_MCF-7_Human1.06705450
88TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.06464111
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06257899
90CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05758810
91EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.04512978
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03823969
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03594873
94GATA3_24758297_ChIP-Seq_MCF-7_Human1.00654327
95SCL_19346495_ChIP-Seq_HPC-7_Human1.00379428
96EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99813515
97SPI1_23547873_ChIP-Seq_NB4_Human0.99459152
98GATA6_25053715_ChIP-Seq_YYC3_Human0.98896635
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98775508
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98480981

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis6.53240596
2MP0005367_renal/urinary_system_phenotyp3.84131869
3MP0000516_abnormal_urinary_system3.84131869
4MP0002909_abnormal_adrenal_gland3.47574862
5MP0003300_gastrointestinal_ulcer2.29625109
6MP0002938_white_spotting2.18655136
7MP0000678_abnormal_parathyroid_gland13.9160187
8MP0009840_abnormal_foam_cell1.82839904
9MP0005451_abnormal_body_composition1.71035256
10MP0003436_decreased_susceptibility_to1.68608221
11MP0001765_abnormal_ion_homeostasis1.68472160
12MP0003656_abnormal_erythrocyte_physiolo1.60920889
13MP0009250_abnormal_appendicular_skeleto1.52186201
14MP0004264_abnormal_extraembryonic_tissu1.38024300
15MP0002168_other_aberrant_phenotype1.37029477
16MP0008260_abnormal_autophagy1.35253569
17MP0002896_abnormal_bone_mineralization1.34514528
18MP0005636_abnormal_mineral_homeostasis1.32702647
19MP0003786_premature_aging1.31498383
20MP0000733_abnormal_muscle_development1.27545316
21MP0004019_abnormal_vitamin_homeostasis1.22347655
22MP0009333_abnormal_splenocyte_physiolog1.20630651
23MP0005058_abnormal_lysosome_morphology1.16759889
24MP0005508_abnormal_skeleton_morphology1.12099151
25MP0009643_abnormal_urine_homeostasis1.09950735
26MP0005365_abnormal_bile_salt1.09106886
27MP0003191_abnormal_cellular_cholesterol1.04303367
28MP0010234_abnormal_vibrissa_follicle1.04006421
29MP0001666_abnormal_nutrient_absorption1.00330384
30MP0005666_abnormal_adipose_tissue0.99141610
31MP0002132_abnormal_respiratory_system0.96936760
32MP0003795_abnormal_bone_structure0.95482293
33MP0000703_abnormal_thymus_morphology0.89938743
34MP0009278_abnormal_bone_marrow0.89481107
35MP0004484_altered_response_of0.88903256
36MP0003186_abnormal_redox_activity0.88635762
37MP0005083_abnormal_biliary_tract0.87091197
38MP0002139_abnormal_hepatobiliary_system0.86050405
39MP0005501_abnormal_skin_physiology0.85955902
40MP0003111_abnormal_nucleus_morphology0.84625736
41MP0004947_skin_inflammation0.83829077
42MP0002877_abnormal_melanocyte_morpholog0.83744796
43MP0005395_other_phenotype0.83599549
44MP0001849_ear_inflammation0.81936200
45MP0002396_abnormal_hematopoietic_system0.81910419
46MP0001730_embryonic_growth_arrest0.81788745
47MP0002108_abnormal_muscle_morphology0.80113139
48MP0005390_skeleton_phenotype0.79737675
49MP0001915_intracranial_hemorrhage0.78178423
50MP0003303_peritoneal_inflammation0.77711085
51MP0005397_hematopoietic_system_phenotyp0.77155738
52MP0001545_abnormal_hematopoietic_system0.77155738
53MP0002113_abnormal_skeleton_development0.72666906
54MP0001958_emphysema0.71744768
55MP0004782_abnormal_surfactant_physiolog0.70993815
56MP0005076_abnormal_cell_differentiation0.70154489
57MP0002796_impaired_skin_barrier0.69931863
58MP0003950_abnormal_plasma_membrane0.69112245
59MP0006036_abnormal_mitochondrial_physio0.67596760
60MP0002249_abnormal_larynx_morphology0.65482168
61MP0002932_abnormal_joint_morphology0.64889868
62MP0008004_abnormal_stomach_pH0.64443968
63MP0003566_abnormal_cell_adhesion0.62987458
64MP0004957_abnormal_blastocyst_morpholog0.62524178
65MP0003693_abnormal_embryo_hatching0.62151150
66MP0000377_abnormal_hair_follicle0.61610218
67MP0005464_abnormal_platelet_physiology0.59240663
68MP0000609_abnormal_liver_physiology0.59227771
69MP0002136_abnormal_kidney_physiology0.58018773
70MP0000163_abnormal_cartilage_morphology0.57704060
71MP0000358_abnormal_cell_content/0.55212601
72MP0003984_embryonic_growth_retardation0.54911459
73MP0002088_abnormal_embryonic_growth/wei0.54502037
74MP0008995_early_reproductive_senescence0.54249874
75MP0000681_abnormal_thyroid_gland0.53778950
76MP0003077_abnormal_cell_cycle0.53461657
77MP0002138_abnormal_hepatobiliary_system0.53322032
78MP0003763_abnormal_thymus_physiology0.52699623
79MP0005375_adipose_tissue_phenotype0.52104861
80MP0000313_abnormal_cell_death0.52089382
81MP0008057_abnormal_DNA_replication0.51471679
82MP0002398_abnormal_bone_marrow0.51436137
83MP0002429_abnormal_blood_cell0.51300757
84MP0005380_embryogenesis_phenotype0.51130105
85MP0001672_abnormal_embryogenesis/_devel0.51130105
86MP0008007_abnormal_cellular_replicative0.50671164
87MP0008058_abnormal_DNA_repair0.50189375
88MP0001873_stomach_inflammation0.49633358
89MP0001790_abnormal_immune_system0.49244155
90MP0005387_immune_system_phenotype0.49244155
91MP0005166_decreased_susceptibility_to0.48438134
92MP0000350_abnormal_cell_proliferation0.48181998
93MP0002080_prenatal_lethality0.48053254
94MP0001348_abnormal_lacrimal_gland0.47458366
95MP0010094_abnormal_chromosome_stability0.46384485
96MP0006035_abnormal_mitochondrial_morpho0.46294093
97MP0001697_abnormal_embryo_size0.46039047
98MP0002971_abnormal_brown_adipose0.45082672
99MP0002086_abnormal_extraembryonic_tissu0.44846491
100MP0003705_abnormal_hypodermis_morpholog0.44657288

Predicted human phenotypes

RankGene SetZ-score
1Hypoparathyroidism (HP:0000829)8.44217517
2Abnormality of calcium-phosphate metabolism (HP:0100530)7.25926683
3Alacrima (HP:0000522)6.73179558
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.62472084
5Hypocalcemia (HP:0002901)5.74058607
6Increased circulating renin level (HP:0000848)5.49220773
7Decreased lacrimation (HP:0000633)5.43003065
8Microretrognathia (HP:0000308)5.28620058
9J-shaped sella turcica (HP:0002680)4.98717940
10Nasolacrimal duct obstruction (HP:0000579)4.95705118
11Conjugated hyperbilirubinemia (HP:0002908)4.44224494
12Metaphyseal irregularity (HP:0003025)4.36762547
13Vacuolated lymphocytes (HP:0001922)4.15727158
14Abnormality of the lacrimal duct (HP:0011481)3.73807415
15Periauricular skin pits (HP:0100277)3.70755325
16Preauricular pit (HP:0004467)3.70755325
17Mixed hearing impairment (HP:0000410)3.56889793
18Hyperparathyroidism (HP:0000843)3.31094343
19Abnormal gallbladder physiology (HP:0012438)3.19827166
20Cholecystitis (HP:0001082)3.19827166
21Deep venous thrombosis (HP:0002625)3.15654622
22Abnormality of the nasolacrimal system (HP:0000614)3.14701508
23Deformed sella turcica (HP:0002681)2.73433461
24Scapular winging (HP:0003691)2.69667359
25Hypomagnesemia (HP:0002917)2.66037328
26Skin pits (HP:0100276)2.58442509
27Athetosis (HP:0002305)2.44484513
28Intellectual disability, moderate (HP:0002342)2.39341019
29Abnormality of the antihelix (HP:0009738)2.33892924
30Reticulocytosis (HP:0001923)2.31481662
31Truncus arteriosus (HP:0001660)2.29224880
32Abnormality of renin-angiotensin system (HP:0000847)2.21139453
33Abnormality of magnesium homeostasis (HP:0004921)2.18357892
34Vascular calcification (HP:0004934)2.15745027
35Hyperthyroidism (HP:0000836)2.11337611
36Exotropia (HP:0000577)2.02349304
37Thickened calvaria (HP:0002684)2.01587339
38Tetany (HP:0001281)15.9116958
39Hyperphosphatemia (HP:0002905)14.9552293
40Ankyloglossia (HP:0010296)1.95667450
41Fair hair (HP:0002286)1.91582316
42Abnormality of monocarboxylic acid metabolism (HP:0010996)1.91062296
43Polydipsia (HP:0001959)1.90651463
44Abnormal drinking behavior (HP:0030082)1.90651463
45Hypophosphatemia (HP:0002148)1.89242276
46Hyperbilirubinemia (HP:0002904)1.87598677
47Nephrocalcinosis (HP:0000121)1.86682095
48Death in childhood (HP:0003819)1.80880200
49Increased serum ferritin (HP:0003281)1.76686251
50Cardiovascular calcification (HP:0011915)1.75501872
51Hypercalciuria (HP:0002150)1.75051305
52Tachypnea (HP:0002789)1.74406513
53Hyperphosphaturia (HP:0003109)1.74261605
54Seborrheic dermatitis (HP:0001051)1.72790018
55Increased IgE level (HP:0003212)1.69958355
56Basal ganglia calcification (HP:0002135)1.68415340
57Polycythemia (HP:0001901)1.68160401
58Aplastic anemia (HP:0001915)1.68031682
59Generalized hypopigmentation of hair (HP:0011358)1.67641819
60Hypertensive crisis (HP:0100735)1.66829644
61Abnormality of glycolysis (HP:0004366)1.66267769
62Abnormality of renal excretion (HP:0011036)1.66040742
63Tapered finger (HP:0001182)1.63413477
64Cholelithiasis (HP:0001081)1.63338639
65Atresia of the external auditory canal (HP:0000413)1.63290294
66Steatorrhea (HP:0002570)1.61821081
67Menstrual irregularities (HP:0000858)1.60105119
68Abnormal urine phosphate concentration (HP:0012599)1.60031188
69Resting tremor (HP:0002322)1.59743667
70Hypotension (HP:0002615)1.58714836
71Abnormality of the sella turcica (HP:0002679)1.58677118
72Sprengel anomaly (HP:0000912)1.58322082
73Hypercalcemia (HP:0003072)1.56243618
74Premature ovarian failure (HP:0008209)1.53773979
75Abnormality of reticulocytes (HP:0004312)1.53653762
76Abnormality of oral frenula (HP:0000190)1.52288772
77Abnormality of the tricuspid valve (HP:0001702)1.51537812
78Increased serum pyruvate (HP:0003542)1.49267719
79Increased intracranial pressure (HP:0002516)1.46816811
80Abnormality of intracranial pressure (HP:0012640)1.46816811
81Hypokalemia (HP:0002900)1.45621923
82Hyperacusis (HP:0010780)1.43319600
83Bowel incontinence (HP:0002607)1.43285591
84Abnormality of iron homeostasis (HP:0011031)1.42840433
85Rough bone trabeculation (HP:0100670)1.41357161
86Dysmetric saccades (HP:0000641)1.40759747
87Abnormal gallbladder morphology (HP:0012437)1.39636283
88Abnormality of the shoulder girdle musculature (HP:0001435)1.36660793
89Fat malabsorption (HP:0002630)1.34872793
90Abnormal large intestine physiology (HP:0012700)1.33854332
91Abnormality of the dental root (HP:0006486)1.33513046
92Taurodontia (HP:0000679)1.33513046
93Abnormality of permanent molar morphology (HP:0011071)1.33513046
94Atelectasis (HP:0100750)1.32626283
95Cardiomegaly (HP:0001640)1.32534420
96Oral leukoplakia (HP:0002745)1.32358883
97Abnormality of the common coagulation pathway (HP:0010990)1.31487932
98Septate vagina (HP:0001153)1.30322752
99Blue sclerae (HP:0000592)1.29395386
100Ragged-red muscle fibers (HP:0003200)1.25132535

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K36.08568750
2PDK25.90356977
3SMG13.16017633
4ICK2.80358336
5TRIB32.77344066
6EIF2AK12.61386601
7ERN12.38580524
8RIPK12.32105593
9EPHA22.17320435
10RIPK42.16345867
11KSR22.09449847
12FGFR42.07900055
13CDK121.96846211
14MAP3K21.91103063
15EEF2K1.81858095
16SCYL21.75674509
17NEK61.65594782
18SIK11.57822058
19IRAK31.51372248
20CLK11.50527513
21PRPF4B1.50453138
22RET1.49240351
23MAP3K11.46411256
24MAP2K31.40782972
25FGFR31.23305445
26STK381.22241862
27RAF11.21782190
28MST41.19836118
29EPHB11.17060249
30MAPK121.15218991
31MAP3K81.14907730
32PTK61.12496191
33MAP3K131.07503013
34PDPK11.04923688
35MTOR0.94608098
36MAP3K70.94420068
37MAP4K10.90729261
38TTK0.90458220
39TYK20.90099597
40PKN20.89230180
41LRRK20.87532044
42MAP3K100.82866236
43MAP2K10.82011001
44PDK10.77965810
45MAPK70.75751880
46JAK20.75395093
47MAP3K60.73788159
48IRAK20.71049631
49MAPK40.70553700
50EPHA30.69594377
51NME20.67798801
52IRAK40.65215845
53MAP3K140.63825742
54BTK0.63823665
55TBK10.63008641
56IRAK10.62887915
57KSR10.62842951
58HIPK20.59813198
59ALK0.57020711
60STK100.56889013
61JAK30.56449739
62YES10.55570109
63PASK0.54218307
64JAK10.54217412
65PRKD20.53228212
66MAPK110.53045457
67RPS6KB20.52199719
68MAP3K120.49975015
69AKT20.49182212
70NME10.48503198
71MAPKAPK50.48068557
72TAOK20.47911744
73ZAP700.45759261
74MAPK30.43325523
75MAP2K60.42820610
76MARK20.42433429
77PAK40.41071953
78TRPM70.39692884
79CDK40.38553154
80CDK20.37407653
81BMPR20.37093562
82BMX0.36441127
83CDK70.34751201
84MAPK10.28944827
85GSK3A0.28593228
86CHEK10.28547291
87BRD40.27219603
88CSNK1E0.26624445
89CSNK2A20.26432858
90SRPK10.25628784
91MAP2K20.25436306
92LATS10.24643476
93HCK0.22474469
94ATM0.22289868
95CDC42BPA0.22155113
96TAOK10.21929390
97CDK10.21784666
98NTRK30.21551778
99MAPK140.21290480
100PRKAA20.20947761

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.80225259
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.61280172
3Inositol phosphate metabolism_Homo sapiens_hsa005623.08287844
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049613.00271138
5Fatty acid biosynthesis_Homo sapiens_hsa000612.53266440
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.44263494
7Arginine biosynthesis_Homo sapiens_hsa002202.30624384
8Complement and coagulation cascades_Homo sapiens_hsa046102.28374038
9Other glycan degradation_Homo sapiens_hsa005112.08849507
10Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.06466356
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.02597113
12Pentose phosphate pathway_Homo sapiens_hsa000301.93462149
13Phosphatidylinositol signaling system_Homo sapiens_hsa040701.88429222
14Fructose and mannose metabolism_Homo sapiens_hsa000511.87609723
15Acute myeloid leukemia_Homo sapiens_hsa052211.76842818
16Pancreatic secretion_Homo sapiens_hsa049721.69806681
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.64990322
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57629028
19Protein digestion and absorption_Homo sapiens_hsa049741.54458346
20Thyroid hormone signaling pathway_Homo sapiens_hsa049191.48674196
21Chronic myeloid leukemia_Homo sapiens_hsa052201.40990720
22Starch and sucrose metabolism_Homo sapiens_hsa005001.40245074
23Carbon metabolism_Homo sapiens_hsa012001.39527574
24Steroid biosynthesis_Homo sapiens_hsa001001.37308566
25Central carbon metabolism in cancer_Homo sapiens_hsa052301.35716007
26Biosynthesis of amino acids_Homo sapiens_hsa012301.35073838
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33849994
28Gastric acid secretion_Homo sapiens_hsa049711.32492611
29Bile secretion_Homo sapiens_hsa049761.30347179
30Staphylococcus aureus infection_Homo sapiens_hsa051501.29975475
31Thyroid cancer_Homo sapiens_hsa052161.25450965
32Fatty acid metabolism_Homo sapiens_hsa012121.25246889
33Galactose metabolism_Homo sapiens_hsa000521.22925589
34Thyroid hormone synthesis_Homo sapiens_hsa049181.22167447
35mTOR signaling pathway_Homo sapiens_hsa041501.20893144
36Pancreatic cancer_Homo sapiens_hsa052121.15024429
37Non-small cell lung cancer_Homo sapiens_hsa052231.13080814
38N-Glycan biosynthesis_Homo sapiens_hsa005101.07692191
39B cell receptor signaling pathway_Homo sapiens_hsa046621.03501585
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02371457
41Pyruvate metabolism_Homo sapiens_hsa006201.01394183
42DNA replication_Homo sapiens_hsa030300.99548117
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.98319544
44Renal cell carcinoma_Homo sapiens_hsa052110.96555033
45VEGF signaling pathway_Homo sapiens_hsa043700.88083189
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83938928
47Adipocytokine signaling pathway_Homo sapiens_hsa049200.81124129
48Spliceosome_Homo sapiens_hsa030400.80280977
49Renin-angiotensin system_Homo sapiens_hsa046140.78474608
50Apoptosis_Homo sapiens_hsa042100.77911388
51Fat digestion and absorption_Homo sapiens_hsa049750.76193528
52Folate biosynthesis_Homo sapiens_hsa007900.75868046
53Vitamin B6 metabolism_Homo sapiens_hsa007500.75498127
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75049543
55Insulin signaling pathway_Homo sapiens_hsa049100.74708990
56Hepatitis C_Homo sapiens_hsa051600.74276127
57Measles_Homo sapiens_hsa051620.74057914
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72415161
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.66610170
60Influenza A_Homo sapiens_hsa051640.66447208
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65674803
62Prolactin signaling pathway_Homo sapiens_hsa049170.65113711
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.62472388
64One carbon pool by folate_Homo sapiens_hsa006700.62203391
65Mineral absorption_Homo sapiens_hsa049780.61279527
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59911256
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.58354293
68Endometrial cancer_Homo sapiens_hsa052130.57466726
69Viral carcinogenesis_Homo sapiens_hsa052030.55654824
70mRNA surveillance pathway_Homo sapiens_hsa030150.55623060
71ErbB signaling pathway_Homo sapiens_hsa040120.53974518
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52807202
73Insulin resistance_Homo sapiens_hsa049310.52189215
74Hepatitis B_Homo sapiens_hsa051610.51156513
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51008955
76Bladder cancer_Homo sapiens_hsa052190.49902904
77Cell cycle_Homo sapiens_hsa041100.49401791
78Herpes simplex infection_Homo sapiens_hsa051680.47953588
79Mismatch repair_Homo sapiens_hsa034300.45839363
80HIF-1 signaling pathway_Homo sapiens_hsa040660.45142322
81Epstein-Barr virus infection_Homo sapiens_hsa051690.44288862
82Toxoplasmosis_Homo sapiens_hsa051450.43023959
83AMPK signaling pathway_Homo sapiens_hsa041520.42604887
84Primary immunodeficiency_Homo sapiens_hsa053400.42396674
85Lysosome_Homo sapiens_hsa041420.42385081
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42376044
87Small cell lung cancer_Homo sapiens_hsa052220.41347222
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.41316752
89FoxO signaling pathway_Homo sapiens_hsa040680.40959219
90T cell receptor signaling pathway_Homo sapiens_hsa046600.38297310
91RNA transport_Homo sapiens_hsa030130.38173934
92Lysine degradation_Homo sapiens_hsa003100.37861653
93Platelet activation_Homo sapiens_hsa046110.37683161
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.37305385
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37235841
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.36275985
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36114926
98Osteoclast differentiation_Homo sapiens_hsa043800.35274602
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34854289
100Fatty acid degradation_Homo sapiens_hsa000710.33178409

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