ZAP70

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.76655634
2regulation of isotype switching to IgG isotypes (GO:0048302)7.28107564
3* negative T cell selection (GO:0043383)7.04175472
4regulation of gamma-delta T cell differentiation (GO:0045586)7.02800921
5* negative thymic T cell selection (GO:0045060)6.72163885
6positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.67985411
7response to interleukin-15 (GO:0070672)6.38431742
8regulation of gamma-delta T cell activation (GO:0046643)6.33727361
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.24469543
10negative regulation of cell killing (GO:0031342)6.24469543
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.19783438
12interferon-gamma production (GO:0032609)6.18885411
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.15982314
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.15982314
15cellular response to interleukin-15 (GO:0071350)6.13228266
16* thymic T cell selection (GO:0045061)5.96588997
17* T cell selection (GO:0045058)5.57812962
18* positive thymic T cell selection (GO:0045059)5.48030738
19T cell costimulation (GO:0031295)5.46975116
20* T cell receptor signaling pathway (GO:0050852)5.45391605
21lymphocyte costimulation (GO:0031294)5.42874896
22* positive T cell selection (GO:0043368)5.37618619
23regulation of T cell tolerance induction (GO:0002664)5.33898711
24regulation of regulatory T cell differentiation (GO:0045589)5.23457775
25regulation of interleukin-2 biosynthetic process (GO:0045076)5.10807787
26antigen processing and presentation of endogenous antigen (GO:0019883)5.03749014
27regulation of interleukin-12 biosynthetic process (GO:0045075)4.94748845
28tolerance induction (GO:0002507)4.93207990
29regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.91916734
30positive regulation of isotype switching (GO:0045830)4.77524242
31activated T cell proliferation (GO:0050798)4.70009317
32regulation of isotype switching (GO:0045191)4.63035261
33positive regulation of granulocyte differentiation (GO:0030854)4.51610789
34* antigen receptor-mediated signaling pathway (GO:0050851)4.43815812
35positive regulation of tolerance induction (GO:0002645)4.42473426
36positive regulation of interleukin-2 production (GO:0032743)4.42256813
37positive regulation of natural killer cell mediated immunity (GO:0002717)4.35221462
38positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.35221462
39regulation of natural killer cell mediated immunity (GO:0002715)4.32899683
40regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.32899683
41regulation of T cell receptor signaling pathway (GO:0050856)4.26825950
42positive regulation of immunoglobulin mediated immune response (GO:0002891)4.19173148
43positive regulation of B cell mediated immunity (GO:0002714)4.19173148
44regulation of B cell receptor signaling pathway (GO:0050855)4.18407279
45positive regulation of humoral immune response (GO:0002922)4.17249097
46regulation of immunoglobulin mediated immune response (GO:0002889)4.14357503
47positive regulation of DNA recombination (GO:0045911)4.09206835
48regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.07949564
49CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.02854461
50* T cell migration (GO:0072678)3.98729611
51regulation of B cell mediated immunity (GO:0002712)3.98261859
52regulation of immunoglobulin production (GO:0002637)3.97849786
53negative regulation of leukocyte mediated immunity (GO:0002704)3.92830754
54detection of bacterium (GO:0016045)3.79706659
55NIK/NF-kappaB signaling (GO:0038061)3.79644126
56regulation of tolerance induction (GO:0002643)3.78474461
57positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.75183709
58positive regulation of immunoglobulin production (GO:0002639)3.71336592
59detection of other organism (GO:0098543)3.69753091
60* regulation of alpha-beta T cell proliferation (GO:0046640)3.69043150
61negative regulation of T cell mediated immunity (GO:0002710)3.68528494
62regulation of leukocyte mediated cytotoxicity (GO:0001910)3.66219301
63regulation of T cell mediated cytotoxicity (GO:0001914)3.66133689
64regulation of response to interferon-gamma (GO:0060330)3.63858290
65regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.62667179
66positive regulation by symbiont of host defense response (GO:0052509)3.59679428
67modulation by symbiont of host defense response (GO:0052031)3.59679428
68modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.59679428
69modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.59679428
70positive regulation by organism of defense response of other organism involved in symbiotic interact3.59679428
71modulation by symbiont of host immune response (GO:0052553)3.59679428
72alpha-beta T cell differentiation (GO:0046632)3.59429236
73B cell receptor signaling pathway (GO:0050853)3.57086399
74response to muramyl dipeptide (GO:0032495)3.55659943
75antigen processing and presentation via MHC class Ib (GO:0002475)3.53711453
76* T cell differentiation (GO:0030217)3.50528004
77alpha-beta T cell activation (GO:0046631)3.50094589
78mast cell activation (GO:0045576)3.49600414
79negative regulation of phagocytosis (GO:0050765)3.48615998
80positive regulation of T cell mediated cytotoxicity (GO:0001916)3.48095270
81* leukocyte aggregation (GO:0070486)3.47102785
82regulation of interleukin-2 production (GO:0032663)3.46633422
83positive regulation of B cell differentiation (GO:0045579)3.46005542
84sequestering of actin monomers (GO:0042989)3.44441581
85T cell homeostasis (GO:0043029)3.43864179
86mucosal-associated lymphoid tissue development (GO:0048537)3.42361747
87Peyers patch development (GO:0048541)3.42361747
88antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.41059933
89cellular extravasation (GO:0045123)3.40693106
90negative regulation of erythrocyte differentiation (GO:0045647)3.38854484
91positive regulation of cell killing (GO:0031343)3.37814669
92negative regulation of interleukin-12 production (GO:0032695)3.36278944
93negative regulation of lymphocyte mediated immunity (GO:0002707)3.34575614
94regulation of cell killing (GO:0031341)3.34265565
95regulation of immunoglobulin secretion (GO:0051023)3.33969082
96positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.32685087
97regulation of granulocyte differentiation (GO:0030852)3.31016607
98type I interferon signaling pathway (GO:0060337)3.30474832
99cellular response to type I interferon (GO:0071357)3.30474832
100JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.30249841
101response to type I interferon (GO:0034340)3.30195770
102positive regulation of lymphocyte mediated immunity (GO:0002708)3.29712280
103regulation of lymphocyte mediated immunity (GO:0002706)3.28470557
104* T cell activation (GO:0042110)3.27960834
105neutrophil activation involved in immune response (GO:0002283)3.26215428
106cellular response to interleukin-4 (GO:0071353)3.26111047
107regulation of interleukin-4 production (GO:0032673)3.25220703
108negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.24908065
109positive regulation of interleukin-4 production (GO:0032753)3.24764057
110T-helper cell differentiation (GO:0042093)3.24492273
111CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.24492273
112negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.23787122
113natural killer cell activation (GO:0030101)3.23194431
114negative regulation of innate immune response (GO:0045824)3.22043734
115regulation of type I interferon-mediated signaling pathway (GO:0060338)3.21109080
116Arp2/3 complex-mediated actin nucleation (GO:0034314)3.20109356
117regulation of defense response to virus by virus (GO:0050690)3.16683062
118* positive regulation of T cell activation (GO:0050870)3.16422398
119positive regulation of T cell differentiation in thymus (GO:0033089)3.14503309
120negative regulation of T cell receptor signaling pathway (GO:0050860)3.14136857
121* positive regulation of alpha-beta T cell proliferation (GO:0046641)3.12238375
122natural killer cell differentiation (GO:0001779)3.11553625
123regulation of chronic inflammatory response (GO:0002676)3.11302732
124tyrosine phosphorylation of STAT protein (GO:0007260)3.08545697
125regulation of B cell differentiation (GO:0045577)3.07028769
126positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.06925219
127* immune response-activating cell surface receptor signaling pathway (GO:0002429)3.05804226
128lymphocyte homeostasis (GO:0002260)3.05235876
129negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.03417578
130alpha-beta T cell activation involved in immune response (GO:0002287)3.03114897
131T cell differentiation involved in immune response (GO:0002292)3.03114897
132alpha-beta T cell differentiation involved in immune response (GO:0002293)3.03114897
133T cell lineage commitment (GO:0002360)3.02076106
134leukocyte degranulation (GO:0043299)2.97591258
135signal complex assembly (GO:0007172)2.96970573
136neutrophil activation (GO:0042119)2.92139058
137* regulation of alpha-beta T cell activation (GO:0046634)2.89918620
138negative regulation of T-helper cell differentiation (GO:0045623)2.88603951
139negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.88603951
140regulation of T cell mediated immunity (GO:0002709)2.87898959
141negative regulation of glycoprotein biosynthetic process (GO:0010561)2.87381546
142respiratory burst (GO:0045730)2.85956801

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.60172657
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.95821353
3MYC_22102868_ChIP-Seq_BL_Human3.88564512
4* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.55183336
5RUNX_20019798_ChIP-Seq_JUKART_Human3.51730457
6* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.48354571
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.45676404
8E2F7_22180533_ChIP-Seq_HELA_Human3.27941251
9* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.22671415
10MYB_26560356_Chip-Seq_TH2_Human3.21978026
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.18328685
12IRF8_22096565_ChIP-ChIP_GC-B_Human3.15319772
13MAF_26560356_Chip-Seq_TH1_Human3.00343839
14MYB_26560356_Chip-Seq_TH1_Human2.71769243
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.71487782
16* UTX_26944678_Chip-Seq_JUKART_Human2.71085153
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.58073284
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.49148985
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.38393191
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.26805416
21VDR_21846776_ChIP-Seq_THP-1_Human2.22708794
22MAF_26560356_Chip-Seq_TH2_Human2.22666124
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.18133360
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.17618729
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.09226877
26* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.07477622
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95523632
28GATA3_27048872_Chip-Seq_THYMUS_Human1.92227330
29* TCF7_22412390_ChIP-Seq_EML_Mouse1.85794222
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.82814188
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.77093929
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.75739158
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68140054
34SPI1_23547873_ChIP-Seq_NB4_Human1.66529628
35KDM2B_26808549_Chip-Seq_DND41_Human1.64873304
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62973182
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61279254
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56963188
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.56117991
40VDR_24763502_ChIP-Seq_THP-1_Human1.54054293
41CIITA_25753668_ChIP-Seq_RAJI_Human1.52561359
42VDR_23849224_ChIP-Seq_CD4+_Human1.51581454
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.50919039
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48172063
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48003853
46FOXP3_21729870_ChIP-Seq_TREG_Human1.42639916
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.40377341
48BP1_19119308_ChIP-ChIP_Hs578T_Human1.38490580
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34998470
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34511619
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33006361
52* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30994109
53GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30728184
54SCL_19346495_ChIP-Seq_HPC-7_Human1.29854060
55GATA1_19941827_ChIP-Seq_MEL_Mouse1.25947394
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25944813
57* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25097752
58MYC_18555785_ChIP-Seq_MESCs_Mouse1.25011349
59RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.23277948
60IRF8_27001747_Chip-Seq_BMDM_Mouse1.22628284
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.18378351
62* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16051953
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15660952
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.15631877
65FOXM1_23109430_ChIP-Seq_U2OS_Human1.15435763
66BCL6_27268052_Chip-Seq_Bcells_Human1.12022205
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.11868859
68GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11470094
69SPI1_23127762_ChIP-Seq_K562_Human1.10968985
70* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10792213
71GATA3_26560356_Chip-Seq_TH2_Human1.10572159
72* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08157410
73VDR_24787735_ChIP-Seq_THP-1_Human1.07043722
74XRN2_22483619_ChIP-Seq_HELA_Human1.06648010
75GABP_17652178_ChIP-ChIP_JURKAT_Human1.06076713
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05624155
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05531450
78* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05076152
79GATA1_19941826_ChIP-Seq_K562_Human1.03945987
80PU_27001747_Chip-Seq_BMDM_Mouse1.02839458
81BCOR_27268052_Chip-Seq_Bcells_Human1.02250321
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01570697
83SA1_27219007_Chip-Seq_ERYTHROID_Human1.00140905
84ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99964162
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99214042
86ELF1_20517297_ChIP-Seq_JURKAT_Human0.98649238
87* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98309767
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97964436
89MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97536012
90EST1_17652178_ChIP-ChIP_JURKAT_Human0.96823692
91CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96510360
92PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95615735
93* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95603914
94TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95370641
95PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92964754
96P68_20966046_ChIP-Seq_HELA_Human0.91269855
97* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89763641
98* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89740316
99HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89417351
100KDM5A_27292631_Chip-Seq_BREAST_Human0.89031925
101ETS1_20019798_ChIP-Seq_JURKAT_Human0.86912511
102* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86747089
103RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85824274
104SMAD_19615063_ChIP-ChIP_OVARY_Human0.83676338
105* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83148640
106GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81872781
107GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81709039
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81218488
109ELK1_19687146_ChIP-ChIP_HELA_Human0.81154091
110FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.79711145
111CTCF_21964334_ChIP-Seq_BJAB-B_Human0.79296577
112IKZF1_21737484_ChIP-ChIP_HCT116_Human0.78462392
113NCOR1_26117541_ChIP-Seq_K562_Human0.78412461
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78151196
115SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78148443
116THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78004698
117STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.77787603
118ETS1_21867929_ChIP-Seq_TH2_Mouse0.77127637
119JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.76922851
120LXR_22292898_ChIP-Seq_THP-1_Human0.76507415
121GABP_19822575_ChIP-Seq_HepG2_Human0.76177149
122* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.75725525
123CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.73982333
124* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73552772
125FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.73451841
126MYC_18358816_ChIP-ChIP_MESCs_Mouse0.72281080

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003763_abnormal_thymus_physiology5.74272633
2MP0005671_abnormal_response_to4.87516129
3MP0000685_abnormal_immune_system3.74958261
4MP0002166_altered_tumor_susceptibility3.24066023
5MP0005387_immune_system_phenotype3.15645615
6MP0001790_abnormal_immune_system3.15645615
7MP0001835_abnormal_antigen_presentation3.13503656
8* MP0001800_abnormal_humoral_immune3.13086959
9MP0009333_abnormal_splenocyte_physiolog2.98169838
10* MP0002398_abnormal_bone_marrow2.83484035
11MP0006082_CNS_inflammation2.79555453
12* MP0005000_abnormal_immune_tolerance2.76755921
13MP0001873_stomach_inflammation2.76220885
14* MP0002723_abnormal_immune_serum2.75677589
15* MP0002420_abnormal_adaptive_immunity2.74330942
16MP0009785_altered_susceptibility_to2.74133159
17* MP0000703_abnormal_thymus_morphology2.72220429
18MP0003300_gastrointestinal_ulcer2.71510626
19* MP0001819_abnormal_immune_cell2.70095897
20MP0002006_tumorigenesis2.62248509
21* MP0002405_respiratory_system_inflammati2.61585558
22MP0003866_abnormal_defecation2.52761384
23MP0005025_abnormal_response_to2.46305153
24* MP0000716_abnormal_immune_system2.43919879
25* MP0002452_abnormal_antigen_presenting2.42884402
26MP0003303_peritoneal_inflammation2.38972941
27* MP0002722_abnormal_immune_system2.33569135
28MP0010155_abnormal_intestine_physiology2.27255045
29MP0002396_abnormal_hematopoietic_system2.21939056
30* MP0000689_abnormal_spleen_morphology2.21463388
31MP0004947_skin_inflammation2.12406839
32* MP0003436_decreased_susceptibility_to2.08369976
33* MP0002429_abnormal_blood_cell1.98062245
34MP0004510_myositis1.93148405
35MP0001853_heart_inflammation1.88172271
36MP0001845_abnormal_inflammatory_respons1.69145134
37MP0004381_abnormal_hair_follicle1.62652931
38* MP0002933_joint_inflammation1.62441374
39MP0002419_abnormal_innate_immunity1.59788940
40MP0002148_abnormal_hypersensitivity_rea1.59531833
41MP0005464_abnormal_platelet_physiology1.46466561
42MP0005310_abnormal_salivary_gland1.41288722
43MP0003172_abnormal_lysosome_physiology1.41220479
44MP0008260_abnormal_autophagy1.36956000
45MP0004808_abnormal_hematopoietic_stem1.36767610
46MP0000858_altered_metastatic_potential1.33413861
47MP0000465_gastrointestinal_hemorrhage1.27623592
48MP0000490_abnormal_crypts_of1.23565383
49MP0002138_abnormal_hepatobiliary_system1.20102856
50MP0003191_abnormal_cellular_cholesterol1.17945710
51MP0002132_abnormal_respiratory_system1.17461439
52MP0008469_abnormal_protein_level1.15009711
53MP0003448_altered_tumor_morphology1.11669884
54MP0002277_abnormal_respiratory_mucosa1.11188896
55MP0002019_abnormal_tumor_incidence1.10372221
56MP0008057_abnormal_DNA_replication1.05419873
57MP0001986_abnormal_taste_sensitivity1.05394859
58MP0003828_pulmonary_edema1.05313043
59MP0008961_abnormal_basal_metabolism1.04050991
60MP0005075_abnormal_melanosome_morpholog0.97256511
61MP0001851_eye_inflammation0.94996598
62MP0003693_abnormal_embryo_hatching0.94547525
63* MP0001533_abnormal_skeleton_physiology0.94016097
64MP0000604_amyloidosis0.93204976
65MP0005023_abnormal_wound_healing0.92788584
66MP0000609_abnormal_liver_physiology0.91385987
67MP0004130_abnormal_muscle_cell0.87783165
68MP0009763_increased_sensitivity_to0.83028193
69MP0003077_abnormal_cell_cycle0.82181710
70MP0004883_abnormal_blood_vessel0.82114162
71MP0002998_abnormal_bone_remodeling0.81667804
72MP0004957_abnormal_blastocyst_morpholog0.81253842
73MP0005397_hematopoietic_system_phenotyp0.80465668
74MP0001545_abnormal_hematopoietic_system0.80465668
75MP0010352_gastrointestinal_tract_polyps0.78011330
76MP0003183_abnormal_peptide_metabolism0.77384292
77MP0009765_abnormal_xenobiotic_induced0.75323665
78MP0002009_preneoplasia0.73514266
79MP0003690_abnormal_glial_cell0.70652429
80MP0000477_abnormal_intestine_morphology0.69998087
81MP0001348_abnormal_lacrimal_gland0.68718979
82MP0005076_abnormal_cell_differentiation0.67662783
83MP0003045_fibrosis0.67252759
84MP0002822_catalepsy0.66421946
85MP0001663_abnormal_digestive_system0.65832186
86MP0001881_abnormal_mammary_gland0.63387773
87MP0000015_abnormal_ear_pigmentation0.61524977
88MP0005451_abnormal_body_composition0.59367596
89* MP0005390_skeleton_phenotype0.58765540
90MP0009764_decreased_sensitivity_to0.57842966
91MP0003453_abnormal_keratinocyte_physiol0.56651951
92MP0010094_abnormal_chromosome_stability0.54436032
93MP0004185_abnormal_adipocyte_glucose0.54220494
94MP0005360_urolithiasis0.53917212
95* MP0003795_abnormal_bone_structure0.52820929
96MP0001216_abnormal_epidermal_layer0.52730784
97MP0005058_abnormal_lysosome_morphology0.52583434
98MP0008873_increased_physiological_sensi0.50031681
99MP0000313_abnormal_cell_death0.49028115
100MP0005381_digestive/alimentary_phenotyp0.48030991
101MP0000598_abnormal_liver_morphology0.48013879
102* MP0003724_increased_susceptibility_to0.47409449
103MP0002136_abnormal_kidney_physiology0.46264249
104MP0003111_abnormal_nucleus_morphology0.46164098
105MP0005365_abnormal_bile_salt0.45523014
106MP0008874_decreased_physiological_sensi0.45359932
107MP0005164_abnormal_response_to0.45301492
108MP0009840_abnormal_foam_cell0.45150723
109MP0008007_abnormal_cellular_replicative0.44906313
110MP0003787_abnormal_imprinting0.43643049
111MP0003091_abnormal_cell_migration0.43104435
112MP0000367_abnormal_coat/_hair0.42039709
113MP0001191_abnormal_skin_condition0.42033825
114MP0002254_reproductive_system_inflammat0.41057391
115MP0008058_abnormal_DNA_repair0.41052306
116MP0000350_abnormal_cell_proliferation0.40835014
117MP0005166_decreased_susceptibility_to0.39942445
118MP0009278_abnormal_bone_marrow0.39672718
119MP0008995_early_reproductive_senescence0.39425551
120MP0002693_abnormal_pancreas_physiology0.39349787
121MP0001765_abnormal_ion_homeostasis0.38848439
122MP0000249_abnormal_blood_vessel0.38683068
123MP0009115_abnormal_fat_cell0.38079810
124MP0003279_aneurysm0.37611008
125MP0004264_abnormal_extraembryonic_tissu0.36939175

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)8.06588786
2Abnormality of T cell number (HP:0011839)7.77427395
3Stomatitis (HP:0010280)6.12134694
4Abnormality of T cells (HP:0002843)5.93353424
5Elevated erythrocyte sedimentation rate (HP:0003565)5.43980169
6Recurrent bronchitis (HP:0002837)5.19151575
7IgG deficiency (HP:0004315)5.02578363
8* Eczematoid dermatitis (HP:0000976)4.77331365
9IgM deficiency (HP:0002850)4.74184416
10Recurrent abscess formation (HP:0002722)4.67789932
11Increased IgM level (HP:0003496)4.63026953
12Recurrent bacterial skin infections (HP:0005406)4.60584578
13Nasal polyposis (HP:0100582)4.60505438
14Myositis (HP:0100614)4.27426942
15B lymphocytopenia (HP:0010976)4.27350080
16Abnormality of B cell number (HP:0010975)4.27350080
17Abnormality of macrophages (HP:0004311)4.14681625
18Recurrent cutaneous fungal infections (HP:0011370)4.10945042
19Chronic mucocutaneous candidiasis (HP:0002728)4.10945042
20* Severe combined immunodeficiency (HP:0004430)4.09066473
21* Combined immunodeficiency (HP:0005387)4.07705316
22Abnormality of T cell physiology (HP:0011840)4.02128910
23Chronic diarrhea (HP:0002028)4.00678515
24Recurrent viral infections (HP:0004429)3.97444702
25Abnormality of eosinophils (HP:0001879)3.87829525
26Optic neuritis (HP:0100653)3.87493101
27Retrobulbar optic neuritis (HP:0100654)3.87493101
28Autoimmune hemolytic anemia (HP:0001890)3.86074651
29Chronic otitis media (HP:0000389)3.85852262
30Joint swelling (HP:0001386)3.85487802
31Abnormality of the nasal mucosa (HP:0000433)3.78995172
32* Recurrent fungal infections (HP:0002841)3.73280570
33Pustule (HP:0200039)3.73056356
34Abnormal delayed hypersensitivity skin test (HP:0002963)3.62218609
35Abnormality of the fingertips (HP:0001211)3.57336505
36Gastrointestinal infarctions (HP:0005244)3.54166331
37Lymphopenia (HP:0001888)3.49574099
38IgA deficiency (HP:0002720)3.48004997
39Thyroiditis (HP:0100646)3.47175407
40Abnormality of cells of the lymphoid lineage (HP:0012140)3.41074258
41Eosinophilia (HP:0001880)3.38250564
42Leukocytosis (HP:0001974)3.38208444
43Hypoplasia of the thymus (HP:0000778)3.38015659
44Recurrent gram-negative bacterial infections (HP:0005420)3.37773758
45Orchitis (HP:0100796)3.35918300
46Papilledema (HP:0001085)3.32228979
47Prolonged bleeding time (HP:0003010)3.32083105
48Hemoptysis (HP:0002105)3.27244313
49Vasculitis (HP:0002633)3.11717067
50Increased density of long bones (HP:0006392)3.09994100
51Pulmonary infiltrates (HP:0002113)3.09946263
52Granulocytopenia (HP:0001913)2.99975551
53Bronchitis (HP:0012387)2.99870859
54Encephalitis (HP:0002383)2.97472995
55Meningitis (HP:0001287)2.92723857
56Lymphoma (HP:0002665)2.85993264
57Hypergammaglobulinemia (HP:0010702)2.81727906
58Keratoconjunctivitis sicca (HP:0001097)2.81563166
59Colitis (HP:0002583)2.81231052
60Arterial thrombosis (HP:0004420)2.79537241
61Gingivitis (HP:0000230)2.77328882
62Hypochromic anemia (HP:0001931)2.73926854
63Thrombocytosis (HP:0001894)2.73085779
64Autoimmune thrombocytopenia (HP:0001973)2.72280309
65Pulmonary embolism (HP:0002204)2.69999407
66Recurrent sinusitis (HP:0011108)2.67760527
67Cellulitis (HP:0100658)2.60708081
68Basal cell carcinoma (HP:0002671)2.58816033
69Chest pain (HP:0100749)2.55106247
70Slow saccadic eye movements (HP:0000514)2.54832744
71Keratoconjunctivitis (HP:0001096)2.53017067
72Gangrene (HP:0100758)2.49163440
73Spontaneous hematomas (HP:0007420)2.47534508
74Urticaria (HP:0001025)2.43840507
75Increased IgE level (HP:0003212)2.42339538
76Obstructive lung disease (HP:0006536)2.41317023
77Chronic obstructive pulmonary disease (HP:0006510)2.41317023
78Mediastinal lymphadenopathy (HP:0100721)2.38395599
79Inflammation of the large intestine (HP:0002037)2.35955871
80Gastrointestinal inflammation (HP:0004386)2.31491550
81Ureteral stenosis (HP:0000071)2.31225960
82Abnormality of the prostate (HP:0008775)2.30458690
83Hypochromic microcytic anemia (HP:0004840)2.29991459
84Seborrheic dermatitis (HP:0001051)2.28476270
85Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.28085919
86Recurrent skin infections (HP:0001581)2.24337068
87Sepsis (HP:0100806)2.23712272
88Recurrent otitis media (HP:0000403)2.22746970
89Amyotrophic lateral sclerosis (HP:0007354)2.20471412
90Epistaxis (HP:0000421)2.20107623
91Anorexia (HP:0002039)2.17210501
92Episodic fever (HP:0001954)2.17133202
93* Panhypogammaglobulinemia (HP:0003139)2.15689371
94Osteomyelitis (HP:0002754)2.11158903
95Hepatitis (HP:0012115)2.10843539
96Persistence of primary teeth (HP:0006335)2.09440848
97Cheilitis (HP:0100825)2.08035590
98Amaurosis fugax (HP:0100576)2.07629062
99Acute hepatic failure (HP:0006554)2.06815704
100Abnormal platelet volume (HP:0011876)2.06382651
101Viral hepatitis (HP:0006562)2.04040971
102Gingival bleeding (HP:0000225)2.03667193
103Ureteral obstruction (HP:0006000)2.03579061
104Stomach cancer (HP:0012126)2.03249942
105Aplasia/Hypoplasia of the thymus (HP:0010515)2.01054488
106Fatigue (HP:0012378)1.97317750
107Agammaglobulinemia (HP:0004432)1.97028131
108Skin ulcer (HP:0200042)1.96856564
109Papilloma (HP:0012740)1.93925648
110Verrucae (HP:0200043)1.93925648
111Chronic sinusitis (HP:0011109)1.91894379
112Polyneuropathy (HP:0001271)1.91893984
113Subacute progressive viral hepatitis (HP:0006572)1.89951445
114Reduced subcutaneous adipose tissue (HP:0003758)1.89113934
115Petechiae (HP:0000967)1.88211614
116Arthralgia (HP:0002829)1.86677385
117Teleangiectasia of the skin (HP:0100585)1.84241179
118Emphysema (HP:0002097)1.81707969
119Gastrointestinal stroma tumor (HP:0100723)1.81313763
120Thrombophlebitis (HP:0004418)1.81102610
121Abnormality of the endocardium (HP:0004306)1.79990086
122Frequent falls (HP:0002359)1.79669463
123Abnormality of the pleura (HP:0002103)1.78860209
124Microcytic anemia (HP:0001935)1.78659603
125Glomerulopathy (HP:0100820)1.78543064
126Bronchiectasis (HP:0002110)1.77651993

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.46547364
2MAP4K16.01084936
3JAK33.36361939
4PRPF4B3.35052647
5ITK3.07207705
6FGFR42.91064983
7RIPK42.90716228
8KDR2.82619667
9* ZAP702.55321986
10IKBKE2.39670031
11TESK22.27960676
12TAOK32.19381919
13TYK22.09904922
14STK102.02840952
15MAP3K141.95090904
16GRK61.88465674
17NLK1.86955208
18* LCK1.79862199
19EEF2K1.76014291
20JAK11.71768428
21FGFR31.65437686
22MAP3K101.63896594
23NME21.60098276
24ERN11.59483947
25TEC1.57996120
26CSK1.57921711
27TBK11.48189370
28SYK1.39502336
29HCK1.35136807
30TRIB31.27421026
31BTK1.26238937
32IKBKB1.23752886
33CAMKK21.20990128
34TAOK11.19007319
35CAMKK11.18999412
36SMG11.16359308
37PRKCQ1.14756248
38PRKCH1.11251443
39BLK1.11213315
40MST41.11002178
41CHUK1.10924573
42RPS6KA41.06867277
43MAP3K71.04192400
44CDK121.03206696
45MAP3K110.93317785
46TNK20.90725349
47JAK20.90719916
48TSSK60.90110300
49PKN20.87143213
50FGR0.87086460
51LRRK20.87075024
52PIM10.84835839
53MAPK120.82025041
54MAP3K10.80016076
55MAP2K30.75875209
56SIK20.75784863
57MAPK70.75619961
58PTK60.73897717
59MAP2K20.73451553
60FGFR10.70522776
61CDC42BPA0.70130075
62KIT0.70107855
63PRKD20.68517491
64TESK10.66597802
65PIM20.66521004
66EPHA30.66410448
67CLK10.65548535
68CDK40.64034044
69TYRO30.63935484
70MARK30.62891266
71MAP3K130.62789514
72PASK0.62576522
73ALK0.61986322
74FES0.60857285
75PDGFRB0.60129809
76KSR20.59545783
77IRAK40.58049314
78SIK30.56636504
79EPHB10.53733648
80* LYN0.53070946
81SIK10.51520738
82MARK20.50640902
83YES10.48848610
84TGFBR10.46886851
85PDK10.44984480
86TTN0.42965688
87STK380.42913522
88RET0.42676283
89RPS6KC10.41745871
90RPS6KL10.41745871
91STK110.40989770
92TAOK20.40623164
93RPS6KA50.39918610
94FYN0.39886165
95RAF10.39826875
96MELK0.39749377
97FGFR20.39682231
98EIF2AK10.39073918
99BRD40.38765276
100DYRK1B0.38115875
101SRPK10.38090459
102PDPK10.36680139
103MAP3K120.36623601
104BMPR20.36570961
105CSF1R0.36377790
106RPS6KA60.35380590
107MAP3K80.35340596
108IGF1R0.34670852
109MAPK110.34161377
110MAP3K30.33414098
111* INSR0.32682124
112HIPK20.32155046
113SGK30.31499987
114CAMK40.30543702
115CDK90.30141179
116TGFBR20.29837414
117NEK20.29298193
118IRAK10.27565540
119NEK60.26347219
120BUB10.26241632
121ICK0.25822832
122ROCK20.24729387
123UHMK10.24303215
124MAP2K60.23629583
125CDK60.22918528
126MAPKAPK20.22630575
127STK40.22229453
128RPS6KA10.21947950
129MAPK30.21895780
130DMPK0.20120468
131CHEK10.19405269
132NTRK20.19378728
133STK240.19283504

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary immunodeficiency_Homo sapiens_hsa053405.52917638
2* T cell receptor signaling pathway_Homo sapiens_hsa046604.22903555
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.82006932
4Allograft rejection_Homo sapiens_hsa053303.65271803
5Graft-versus-host disease_Homo sapiens_hsa053323.37684463
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.09445160
7Autoimmune thyroid disease_Homo sapiens_hsa053203.06324602
8* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.94857465
9Measles_Homo sapiens_hsa051622.88439832
10Antigen processing and presentation_Homo sapiens_hsa046122.67519604
11* NF-kappa B signaling pathway_Homo sapiens_hsa040642.45246001
12Asthma_Homo sapiens_hsa053102.06735821
13Hematopoietic cell lineage_Homo sapiens_hsa046402.01521687
14Viral myocarditis_Homo sapiens_hsa054161.95095879
15Jak-STAT signaling pathway_Homo sapiens_hsa046301.81088566
16Leishmaniasis_Homo sapiens_hsa051401.77683959
17Osteoclast differentiation_Homo sapiens_hsa043801.67152348
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.57464224
19Herpes simplex infection_Homo sapiens_hsa051681.47636092
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44553241
21Type I diabetes mellitus_Homo sapiens_hsa049401.43758188
22B cell receptor signaling pathway_Homo sapiens_hsa046621.43483770
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37743255
24Acute myeloid leukemia_Homo sapiens_hsa052211.32537842
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.23304347
26Toxoplasmosis_Homo sapiens_hsa051451.22391174
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.22237209
28Shigellosis_Homo sapiens_hsa051311.21239711
29HTLV-I infection_Homo sapiens_hsa051661.21004007
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19966437
31Ribosome_Homo sapiens_hsa030101.19616448
32Hepatitis B_Homo sapiens_hsa051611.16262824
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12016457
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10698179
35Chemokine signaling pathway_Homo sapiens_hsa040621.10375731
36Other glycan degradation_Homo sapiens_hsa005111.10156787
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07889885
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06533349
39Spliceosome_Homo sapiens_hsa030401.04481861
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02855271
41Staphylococcus aureus infection_Homo sapiens_hsa051500.97684811
42Leukocyte transendothelial migration_Homo sapiens_hsa046700.97112485
43TNF signaling pathway_Homo sapiens_hsa046680.94737268
44Endometrial cancer_Homo sapiens_hsa052130.93757155
45Epstein-Barr virus infection_Homo sapiens_hsa051690.93746020
46Prolactin signaling pathway_Homo sapiens_hsa049170.92331856
47Influenza A_Homo sapiens_hsa051640.92100229
48Apoptosis_Homo sapiens_hsa042100.90122224
49Legionellosis_Homo sapiens_hsa051340.88847774
50Choline metabolism in cancer_Homo sapiens_hsa052310.86616239
51Pancreatic cancer_Homo sapiens_hsa052120.86570251
52Chronic myeloid leukemia_Homo sapiens_hsa052200.86142335
53Renal cell carcinoma_Homo sapiens_hsa052110.82159328
54Inositol phosphate metabolism_Homo sapiens_hsa005620.81503068
55Viral carcinogenesis_Homo sapiens_hsa052030.80427533
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.74774628
57Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74417249
58Colorectal cancer_Homo sapiens_hsa052100.73777882
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72297048
60African trypanosomiasis_Homo sapiens_hsa051430.71895777
61Proteasome_Homo sapiens_hsa030500.69733500
62Malaria_Homo sapiens_hsa051440.69414051
63Hepatitis C_Homo sapiens_hsa051600.66020759
64VEGF signaling pathway_Homo sapiens_hsa043700.64745024
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63747123
66One carbon pool by folate_Homo sapiens_hsa006700.63144679
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62957385
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.61915842
69RNA degradation_Homo sapiens_hsa030180.61793572
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60662932
71Dorso-ventral axis formation_Homo sapiens_hsa043200.56940642
72RNA transport_Homo sapiens_hsa030130.56803849
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56430145
74mRNA surveillance pathway_Homo sapiens_hsa030150.56357839
75Salmonella infection_Homo sapiens_hsa051320.53025309
76p53 signaling pathway_Homo sapiens_hsa041150.52104320
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51497251
78GnRH signaling pathway_Homo sapiens_hsa049120.50802149
79Platelet activation_Homo sapiens_hsa046110.50623960
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.49224064
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48912380
82Phagosome_Homo sapiens_hsa041450.48872405
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48745907
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48355373
85Regulation of autophagy_Homo sapiens_hsa041400.48125601
86Long-term potentiation_Homo sapiens_hsa047200.47904618
87Pertussis_Homo sapiens_hsa051330.47684074
88Tuberculosis_Homo sapiens_hsa051520.47398254
89DNA replication_Homo sapiens_hsa030300.46437108
90ErbB signaling pathway_Homo sapiens_hsa040120.45936939
91Glioma_Homo sapiens_hsa052140.44756257
92Non-homologous end-joining_Homo sapiens_hsa034500.44194636
93Base excision repair_Homo sapiens_hsa034100.42958456
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42651280
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41137167
96Small cell lung cancer_Homo sapiens_hsa052220.39966053
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.39105604
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.38316949
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37652897
100* Ras signaling pathway_Homo sapiens_hsa040140.37330914
101Caffeine metabolism_Homo sapiens_hsa002320.35544567
102Thyroid cancer_Homo sapiens_hsa052160.33883787
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32926059
104Type II diabetes mellitus_Homo sapiens_hsa049300.32848986
105Endocytosis_Homo sapiens_hsa041440.32525764
106Mismatch repair_Homo sapiens_hsa034300.32001006
107Insulin resistance_Homo sapiens_hsa049310.29324111
108MAPK signaling pathway_Homo sapiens_hsa040100.28984006
109Notch signaling pathway_Homo sapiens_hsa043300.27771464
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26784671
111Nucleotide excision repair_Homo sapiens_hsa034200.25512005
112Non-small cell lung cancer_Homo sapiens_hsa052230.23536368
113Sulfur relay system_Homo sapiens_hsa041220.23306922
114Rheumatoid arthritis_Homo sapiens_hsa053230.23293873
115Pentose phosphate pathway_Homo sapiens_hsa000300.21983642
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.21356926
117RNA polymerase_Homo sapiens_hsa030200.21156580
118FoxO signaling pathway_Homo sapiens_hsa040680.20644281
119Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.20142851
120Prostate cancer_Homo sapiens_hsa052150.17514913
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.17411344
122Rap1 signaling pathway_Homo sapiens_hsa040150.16392650
123Lysine degradation_Homo sapiens_hsa003100.14799383
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.13768782
125Pyrimidine metabolism_Homo sapiens_hsa002400.13078371
126mTOR signaling pathway_Homo sapiens_hsa041500.12949380
127HIF-1 signaling pathway_Homo sapiens_hsa040660.12613642

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