ZADH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.41434768
2L-phenylalanine catabolic process (GO:0006559)6.41434768
3L-phenylalanine metabolic process (GO:0006558)6.16097880
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.16097880
5aromatic amino acid family catabolic process (GO:0009074)5.56677532
6alpha-linolenic acid metabolic process (GO:0036109)5.41861098
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.39003621
8glyoxylate metabolic process (GO:0046487)5.19897187
9lysine catabolic process (GO:0006554)5.07733978
10lysine metabolic process (GO:0006553)5.07733978
11kynurenine metabolic process (GO:0070189)5.03351639
12bile acid biosynthetic process (GO:0006699)5.03048832
13sulfur amino acid catabolic process (GO:0000098)4.92287238
14cysteine metabolic process (GO:0006534)4.87589254
15tryptophan catabolic process (GO:0006569)4.82765561
16indole-containing compound catabolic process (GO:0042436)4.82765561
17indolalkylamine catabolic process (GO:0046218)4.82765561
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.80689031
19protein carboxylation (GO:0018214)4.74937940
20peptidyl-glutamic acid carboxylation (GO:0017187)4.74937940
21negative regulation of fibrinolysis (GO:0051918)4.60932432
22tryptophan metabolic process (GO:0006568)4.56071761
23urea cycle (GO:0000050)4.53898366
24urea metabolic process (GO:0019627)4.53898366
25complement activation, alternative pathway (GO:0006957)4.48653508
26high-density lipoprotein particle remodeling (GO:0034375)4.46137020
27regulation of triglyceride catabolic process (GO:0010896)4.43773875
28amino-acid betaine metabolic process (GO:0006577)4.40537104
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.37747368
30regulation of protein activation cascade (GO:2000257)4.36154762
31regulation of fibrinolysis (GO:0051917)4.30237838
32regulation of female receptivity (GO:0045924)4.26915202
33bile acid metabolic process (GO:0008206)4.24485888
34cellular ketone body metabolic process (GO:0046950)4.22477108
35nitrogen cycle metabolic process (GO:0071941)4.17457806
36regulation of complement activation (GO:0030449)4.12673660
37ethanol oxidation (GO:0006069)4.09504593
38somite development (GO:0061053)4.09064689
39serine family amino acid catabolic process (GO:0009071)4.08005123
40fatty acid beta-oxidation (GO:0006635)4.06903814
41homocysteine metabolic process (GO:0050667)4.05155651
42plasma lipoprotein particle clearance (GO:0034381)4.03020728
43alpha-amino acid catabolic process (GO:1901606)4.00155756
442-oxoglutarate metabolic process (GO:0006103)3.99170903
45short-chain fatty acid metabolic process (GO:0046459)3.97462596
46acylglycerol homeostasis (GO:0055090)3.97117040
47triglyceride homeostasis (GO:0070328)3.97117040
48piRNA metabolic process (GO:0034587)3.96681071
49acetyl-CoA metabolic process (GO:0006084)3.95398081
50aromatic amino acid family metabolic process (GO:0009072)3.94008633
51reverse cholesterol transport (GO:0043691)3.93616406
52fatty acid oxidation (GO:0019395)3.88322240
53aspartate family amino acid catabolic process (GO:0009068)3.85744593
54macromolecular complex remodeling (GO:0034367)3.85010507
55plasma lipoprotein particle remodeling (GO:0034369)3.85010507
56protein-lipid complex remodeling (GO:0034368)3.85010507
57tyrosine metabolic process (GO:0006570)3.84127714
58coenzyme catabolic process (GO:0009109)3.84100746
59valine metabolic process (GO:0006573)3.83789530
60lipid oxidation (GO:0034440)3.81639602
61cellular glucuronidation (GO:0052695)3.81213574
62rRNA catabolic process (GO:0016075)3.78934684
63regulation of cholesterol esterification (GO:0010872)3.78565697
64negative regulation of cholesterol transport (GO:0032375)3.77928772
65negative regulation of sterol transport (GO:0032372)3.77928772
66cellular amino acid catabolic process (GO:0009063)3.77576601
67positive regulation of fatty acid beta-oxidation (GO:0032000)3.77295671
68fatty acid catabolic process (GO:0009062)3.77066385
69epoxygenase P450 pathway (GO:0019373)3.72587712
70glutamate metabolic process (GO:0006536)3.71244702
71monocarboxylic acid catabolic process (GO:0072329)3.70432329
72cellular modified amino acid catabolic process (GO:0042219)3.66445186
73phospholipid efflux (GO:0033700)3.65526248
74carnitine metabolic process (GO:0009437)3.64863118
75positive regulation of lipid catabolic process (GO:0050996)3.63899879
76ketone body metabolic process (GO:1902224)3.62184861
77regulation of mesoderm development (GO:2000380)3.61025473
78water-soluble vitamin biosynthetic process (GO:0042364)3.58389562
79fatty acid transmembrane transport (GO:1902001)3.58020819
80regulation of cholesterol homeostasis (GO:2000188)3.55945056
81benzene-containing compound metabolic process (GO:0042537)3.55681697
82bile acid and bile salt transport (GO:0015721)3.55032878
83dicarboxylic acid biosynthetic process (GO:0043650)3.55002329
84DNA deamination (GO:0045006)3.54004741
85carboxylic acid catabolic process (GO:0046395)3.53982514
86organic acid catabolic process (GO:0016054)3.53982514
87behavioral response to nicotine (GO:0035095)3.52935482
88interkinetic nuclear migration (GO:0022027)3.52380663
89RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.51858057
90drug catabolic process (GO:0042737)3.51193839
91female mating behavior (GO:0060180)3.50885204
92regulation of cholesterol metabolic process (GO:0090181)3.47421266
93phospholipid homeostasis (GO:0055091)3.45702328
94glucuronate metabolic process (GO:0019585)3.38581017
95uronic acid metabolic process (GO:0006063)3.38581017
96serine family amino acid metabolic process (GO:0009069)3.38535114
97cholesterol efflux (GO:0033344)3.38204788
98fibrinolysis (GO:0042730)3.36175728
99indolalkylamine metabolic process (GO:0006586)3.35720133
100glycine metabolic process (GO:0006544)3.34916015
101negative regulation of lipase activity (GO:0060192)3.34771917
102flavonoid metabolic process (GO:0009812)3.31720186
103cholesterol homeostasis (GO:0042632)3.31305672
104positive regulation of fatty acid oxidation (GO:0046321)3.30081203
105plasma lipoprotein particle assembly (GO:0034377)3.30068128
106regulation of fatty acid beta-oxidation (GO:0031998)3.29936687
107aldehyde catabolic process (GO:0046185)3.29451827
108drug transmembrane transport (GO:0006855)3.29124204
109carnitine shuttle (GO:0006853)3.28858417
110sterol homeostasis (GO:0055092)3.28038752
111negative regulation of synaptic transmission, GABAergic (GO:0032229)3.25695409
112positive regulation of triglyceride lipase activity (GO:0061365)3.24594817
113positive regulation of lipoprotein lipase activity (GO:0051006)3.24594817
114phosphatidylethanolamine metabolic process (GO:0046337)3.19429761
115positive regulation of meiosis (GO:0045836)3.16969604
116phosphatidylethanolamine biosynthetic process (GO:0006646)3.11042860
117negative regulation of actin filament bundle assembly (GO:0032232)3.09718588
118L-fucose catabolic process (GO:0042355)3.04695320
119fucose catabolic process (GO:0019317)3.04695320
120L-fucose metabolic process (GO:0042354)3.04695320
121adaptation of signaling pathway (GO:0023058)3.01258061
122detection of light stimulus involved in visual perception (GO:0050908)2.97257682
123detection of light stimulus involved in sensory perception (GO:0050962)2.97257682
124DNA methylation involved in gamete generation (GO:0043046)2.96498781
125protein polyglutamylation (GO:0018095)2.95336713
126positive regulation of glomerulus development (GO:0090193)2.95134817
127DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.91528517
128positive regulation of meiotic cell cycle (GO:0051446)2.88570620
129regulation of rhodopsin mediated signaling pathway (GO:0022400)2.86192252
130regulation of glomerulus development (GO:0090192)2.82911565
131negative regulation of mast cell activation (GO:0033004)2.82721211
132negative regulation of cytosolic calcium ion concentration (GO:0051481)2.79807901
133negative regulation of stress fiber assembly (GO:0051497)2.78794592
134axoneme assembly (GO:0035082)2.78754665
135transmission of nerve impulse (GO:0019226)2.78070143
136primary amino compound metabolic process (GO:1901160)2.76096778
137prostate gland growth (GO:0060736)2.74055609
138membrane depolarization during action potential (GO:0086010)2.71741142
139aggressive behavior (GO:0002118)2.71028751
140serotonin metabolic process (GO:0042428)2.70253679
141indole-containing compound metabolic process (GO:0042430)2.69652481
142regulation of skeletal muscle contraction (GO:0014819)2.68651595
143detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.68523441
144rhodopsin mediated signaling pathway (GO:0016056)2.68225979
145kidney morphogenesis (GO:0060993)2.67872419
146neuronal action potential (GO:0019228)2.67473455
147regulation of action potential (GO:0098900)2.67084333
148action potential (GO:0001508)2.66943355
149epithelial cilium movement (GO:0003351)2.66445638
150positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.66184500
151endoderm formation (GO:0001706)2.64976391
152thyroid hormone metabolic process (GO:0042403)2.62488177
153G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.59165529
154gamma-aminobutyric acid transport (GO:0015812)2.57175606
155cornea development in camera-type eye (GO:0061303)2.56645451
156parturition (GO:0007567)2.56439473
157negative regulation of neurotransmitter transport (GO:0051589)2.56094848
158regulation of neurotransmitter uptake (GO:0051580)2.54761783
159pharyngeal system development (GO:0060037)2.53907737
160regulation of sequestering of triglyceride (GO:0010889)2.53576760
161positive regulation of organelle assembly (GO:1902117)2.51963045
162embryonic epithelial tube formation (GO:0001838)2.51495370
163sulfation (GO:0051923)2.49926454
164positive regulation of oligodendrocyte differentiation (GO:0048714)2.48295021
165protein K6-linked ubiquitination (GO:0085020)2.47815138
166gamma-aminobutyric acid signaling pathway (GO:0007214)2.46789524
167glycerophospholipid catabolic process (GO:0046475)2.46701175
168preassembly of GPI anchor in ER membrane (GO:0016254)2.46207415
169protein K11-linked deubiquitination (GO:0035871)2.45793656
170negative regulation of astrocyte differentiation (GO:0048712)2.43961327
171dentate gyrus development (GO:0021542)2.43832182
172dopamine transport (GO:0015872)2.39610150
173positive regulation of triglyceride biosynthetic process (GO:0010867)2.39190512
174male meiosis (GO:0007140)2.38138076
175inositol phosphate catabolic process (GO:0071545)2.36134227
176adenosine metabolic process (GO:0046085)2.34728314
177regulation of DNA endoreduplication (GO:0032875)2.33427864
178DNA damage response, signal transduction resulting in transcription (GO:0042772)2.32933278
179regulation of acrosome reaction (GO:0060046)2.32511788
180male meiosis I (GO:0007141)2.32454337
181reflex (GO:0060004)2.31398394
182exogenous drug catabolic process (GO:0042738)2.29732525
183multicellular organismal signaling (GO:0035637)2.29331883
184regulation of germinal center formation (GO:0002634)2.28661879
185cellular response to ATP (GO:0071318)2.28387827
186oxidative demethylation (GO:0070989)2.28366400
187pancreas development (GO:0031016)2.27999688
188cAMP catabolic process (GO:0006198)2.27639042

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.98409077
2RXR_22158963_ChIP-Seq_LIVER_Mouse7.03778754
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.25869741
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.15713347
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.57772019
6* EGR1_23403033_ChIP-Seq_LIVER_Mouse4.82134637
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.32538229
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.63080545
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.47526674
10EZH2_22144423_ChIP-Seq_EOC_Human3.46057459
11GBX2_23144817_ChIP-Seq_PC3_Human3.45219566
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.16002239
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.06183543
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.92366730
15VDR_22108803_ChIP-Seq_LS180_Human2.86545079
16IGF1R_20145208_ChIP-Seq_DFB_Human2.85842507
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.62862717
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.56484477
19CLOCK_20551151_ChIP-Seq_293T_Human2.48001740
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.39327878
21ZNF274_21170338_ChIP-Seq_K562_Hela2.38339906
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.11078934
23RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08699839
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03879803
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03680416
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.99028063
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90770973
28GATA1_22025678_ChIP-Seq_K562_Human1.89688553
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.84911171
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82457911
31* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.77945701
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.77941586
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76509142
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76169068
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72552722
36P300_19829295_ChIP-Seq_ESCs_Human1.72071144
37ER_23166858_ChIP-Seq_MCF-7_Human1.68889674
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67422997
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67124299
40EWS_26573619_Chip-Seq_HEK293_Human1.65290474
41SMAD4_21799915_ChIP-Seq_A2780_Human1.64255349
42STAT3_23295773_ChIP-Seq_U87_Human1.64143369
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61583483
44FOXA2_19822575_ChIP-Seq_HepG2_Human1.57694226
45TCF4_23295773_ChIP-Seq_U87_Human1.57145279
46FUS_26573619_Chip-Seq_HEK293_Human1.57056154
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56643822
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56328151
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.55390138
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54445431
51TAF15_26573619_Chip-Seq_HEK293_Human1.53994695
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.52967282
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.51819504
54AR_25329375_ChIP-Seq_VCAP_Human1.49811935
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.49470048
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.48365305
57EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.47374726
58BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45581869
59RNF2_27304074_Chip-Seq_NSC_Mouse1.44761467
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44635460
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.42510594
62* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.41901632
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40281667
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39623956
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39398061
66BCAT_22108803_ChIP-Seq_LS180_Human1.38824647
67SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.38390694
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.38336785
69STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37099427
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35310356
71* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35138622
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.35090534
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34507350
74* PRDM14_20953172_ChIP-Seq_ESCs_Human1.34037156
75TP53_22573176_ChIP-Seq_HFKS_Human1.33083706
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33060453
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.32064491
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31799720
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.31608986
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31183022
81ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.30210236
82SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29739388
83REST_21632747_ChIP-Seq_MESCs_Mouse1.29572690
84P53_22387025_ChIP-Seq_ESCs_Mouse1.28191783
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28147222
86CBP_20019798_ChIP-Seq_JUKART_Human1.27109517
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27109517
88* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26742139
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26028971
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.24187763
91* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.24022228
92TRIM28_21343339_ChIP-Seq_HEK293_Human1.23196604
93ESR2_21235772_ChIP-Seq_MCF-7_Human1.22890148
94SOX2_19829295_ChIP-Seq_ESCs_Human1.22641424
95NANOG_19829295_ChIP-Seq_ESCs_Human1.22641424
96EZH2_27304074_Chip-Seq_ESCs_Mouse1.22500985
97CRX_20693478_ChIP-Seq_RETINA_Mouse1.20573563
98ZNF263_19887448_ChIP-Seq_K562_Human1.19757001
99* HNF4A_19822575_ChIP-Seq_HepG2_Human1.18464373
100* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17408322
101IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17070159
102ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16242633
103RUNX2_22187159_ChIP-Seq_PCA_Human1.15875918
104SMAD4_21741376_ChIP-Seq_EPCs_Human1.15661189
105NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15629531
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15606794
107SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15184414
108TCF4_22108803_ChIP-Seq_LS180_Human1.14630268
109IRF1_19129219_ChIP-ChIP_H3396_Human1.14155842
110EED_16625203_ChIP-ChIP_MESCs_Mouse1.13978895
111E2F1_18555785_Chip-Seq_ESCs_Mouse1.13063511
112IRF8_22096565_ChIP-ChIP_GC-B_Human1.12573883
113SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12393366
114TP63_17297297_ChIP-ChIP_HaCaT_Human1.11941140
115OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11846449
116KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10861340
117NOTCH1_21737748_ChIP-Seq_TLL_Human1.10606605
118* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10184297
119SOX2_21211035_ChIP-Seq_LN229_Gbm1.10004288
120* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09418224
121STAT3_18555785_Chip-Seq_ESCs_Mouse1.09194351
122* TBX20_22080862_ChIP-Seq_HEART_Mouse1.09143995
123* TBX20_22328084_ChIP-Seq_HEART_Mouse1.09143995
124SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09059446
125JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08514049
126FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07295875
127LXR_22292898_ChIP-Seq_THP-1_Human1.06279631
128CDX2_22108803_ChIP-Seq_LS180_Human1.05263795
129ESR1_20079471_ChIP-ChIP_T-47D_Human1.04333426
130RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03818341
131SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03373743
132NCOR_22424771_ChIP-Seq_293T_Human1.03232585
133MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02732459
134EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01914436
135FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01895758
136BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00753831
137TAL1_26923725_Chip-Seq_HPCs_Mouse1.00382189
138OCT4_18555785_Chip-Seq_ESCs_Mouse1.00320362
139CMYC_18555785_Chip-Seq_ESCs_Mouse1.00227139
140GATA4_25053715_ChIP-Seq_YYC3_Human0.98998419
141PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97590642
142FOXO3_23340844_ChIP-Seq_DLD1_Human0.95731328
143Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95488375
144NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94576299
145NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94576299
146ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91079449
147ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89376356
148RACK7_27058665_Chip-Seq_MCF-7_Human0.89070436
149PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88569826
150GATA1_19941826_ChIP-Seq_K562_Human0.87534672
151HTT_18923047_ChIP-ChIP_STHdh_Human0.87379731
152ESR1_21235772_ChIP-Seq_MCF-7_Human0.84407944
153RXRA_24833708_ChIP-Seq_LIVER_Mouse0.81784739
154AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81485973
155SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79423745
156ELK3_25401928_ChIP-Seq_HUVEC_Human0.79091177
157PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.78881554
158SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77029135
159KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.76942730
160EP300_21415370_ChIP-Seq_HL-1_Mouse0.75834039
161GATA2_19941826_ChIP-Seq_K562_Human0.75147815
162EGR1_19032775_ChIP-ChIP_M12_Human0.74856939
163* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.73998582
164ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.73214956
165GATA2_21666600_ChIP-Seq_HMVEC_Human0.72725465
166* SOX2_20726797_ChIP-Seq_SW620_Human0.71296369
167GATA1_19941827_ChIP-Seq_MEL_Mouse0.70532305
168AUTS2_25519132_ChIP-Seq_293T-REX_Human0.69387326
169RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.68747331
170GATA6_25053715_ChIP-Seq_YYC3_Human0.67976893
171* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.67073444
172P63_26484246_Chip-Seq_KERATINOCYTES_Human0.66906967
173BRD4_27068464_Chip-Seq_AML-cells_Mouse0.65977476
174NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.65380471
175TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.65003121
176CDX2_20551321_ChIP-Seq_CACO-2_Human0.64619364
177FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.64361566
178* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.62818740
179SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.62064976
180SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.61222790
181FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.60944107
182ATF3_27146783_Chip-Seq_COLON_Human0.60809430
183FOXA1_25552417_ChIP-Seq_VCAP_Human0.60348598
184SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.60002488
185CEBPB_22108803_ChIP-Seq_LS180_Human0.59815443
186P300_27058665_Chip-Seq_ZR-75-30cells_Human0.59192792
187RAD21_21589869_ChIP-Seq_MESCs_Mouse0.58088134
188STAT3_1855785_ChIP-Seq_MESCs_Mouse0.57706301
189BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.57390692
190KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.57071262
191CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.56922482
192GATA3_24758297_ChIP-Seq_MCF-7_Human0.56866520
193SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.56196444
194ESR1_15608294_ChIP-ChIP_MCF-7_Human0.55760839
195RARA_24833708_ChIP-Seq_LIVER_Mouse0.54190558
196PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53738167
197CREB1_26743006_Chip-Seq_LNCaP_Human0.53289512

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.01011819
2MP0005360_urolithiasis6.42694511
3MP0005085_abnormal_gallbladder_physiolo5.36753851
4MP0005365_abnormal_bile_salt5.26519024
5MP0008875_abnormal_xenobiotic_pharmacok4.43441732
6MP0005646_abnormal_pituitary_gland4.12114524
7MP0003806_abnormal_nucleotide_metabolis3.65627204
8MP0003252_abnormal_bile_duct3.46807600
9MP0004885_abnormal_endolymph3.30543715
10MP0010329_abnormal_lipoprotein_level3.17145268
11MP0009840_abnormal_foam_cell2.99565341
12MP0002876_abnormal_thyroid_physiology2.88914022
13MP0005083_abnormal_biliary_tract2.86760056
14MP0003195_calcinosis2.73481078
15MP0004145_abnormal_muscle_electrophysio2.67049342
16MP0005332_abnormal_amino_acid2.60606777
17MP0002102_abnormal_ear_morphology2.58058595
18MP0001968_abnormal_touch/_nociception2.51852317
19MP0003283_abnormal_digestive_organ2.51272527
20MP0008877_abnormal_DNA_methylation2.46742151
21MP0001666_abnormal_nutrient_absorption2.42878653
22MP0009780_abnormal_chondrocyte_physiolo2.27738720
23MP0000569_abnormal_digit_pigmentation2.16893655
24MP0002736_abnormal_nociception_after2.13000598
25MP0002118_abnormal_lipid_homeostasis2.10266378
26MP0003191_abnormal_cellular_cholesterol2.08880064
27MP0000609_abnormal_liver_physiology2.01434368
28MP0003705_abnormal_hypodermis_morpholog1.99041708
29MP0006292_abnormal_olfactory_placode1.92288069
30MP0005551_abnormal_eye_electrophysiolog1.91214947
31MP0002735_abnormal_chemical_nociception1.89942091
32MP0005319_abnormal_enzyme/_coenzyme1.81459649
33MP0009745_abnormal_behavioral_response1.75486500
34MP0004130_abnormal_muscle_cell1.70585837
35MP0001486_abnormal_startle_reflex1.69035337
36MP0002837_dystrophic_cardiac_calcinosis1.68405329
37MP0002138_abnormal_hepatobiliary_system1.66760052
38MP0005584_abnormal_enzyme/coenzyme_acti1.65372342
39MP0002272_abnormal_nervous_system1.64547765
40MP0004019_abnormal_vitamin_homeostasis1.61250953
41MP0006072_abnormal_retinal_apoptosis1.56720334
42MP0001501_abnormal_sleep_pattern1.53908850
43MP0000631_abnormal_neuroendocrine_gland1.52795252
44MP0003868_abnormal_feces_composition1.50626421
45MP0002160_abnormal_reproductive_system1.46498424
46MP0009643_abnormal_urine_homeostasis1.46466475
47MP0005645_abnormal_hypothalamus_physiol1.41939085
48MP0004142_abnormal_muscle_tone1.41924970
49MP0003879_abnormal_hair_cell1.41202639
50MP0000427_abnormal_hair_cycle1.41197015
51MP0005670_abnormal_white_adipose1.36536996
52MP0008872_abnormal_physiological_respon1.34977129
53MP0004215_abnormal_myocardial_fiber1.34967836
54MP0000372_irregular_coat_pigmentation1.33544973
55MP0009046_muscle_twitch1.31922904
56MP0003656_abnormal_erythrocyte_physiolo1.30022626
57MP0005389_reproductive_system_phenotype1.29775145
58MP0005253_abnormal_eye_physiology1.29203480
59MP0005174_abnormal_tail_pigmentation1.28853868
60MP0005451_abnormal_body_composition1.27633756
61MP0002064_seizures1.26031076
62MP0003119_abnormal_digestive_system1.25485222
63MP0008438_abnormal_cutaneous_collagen1.25454650
64MP0001986_abnormal_taste_sensitivity1.24355755
65MP0003186_abnormal_redox_activity1.24322844
66MP0005666_abnormal_adipose_tissue1.22410973
67MP0001485_abnormal_pinna_reflex1.22006907
68MP0003880_abnormal_central_pattern1.21181927
69MP0004924_abnormal_behavior1.20298705
70MP0005386_behavior/neurological_phenoty1.20298705
71MP0000383_abnormal_hair_follicle1.19766607
72MP0002234_abnormal_pharynx_morphology1.16895894
73MP0006036_abnormal_mitochondrial_physio1.15793071
74MP0010368_abnormal_lymphatic_system1.13839088
75MP0003787_abnormal_imprinting1.12413343
76MP0000598_abnormal_liver_morphology1.11161562
77MP0001764_abnormal_homeostasis1.10716299
78MP0003635_abnormal_synaptic_transmissio1.10715881
79MP0002971_abnormal_brown_adipose1.08606881
80MP0000013_abnormal_adipose_tissue1.03733933
81MP0006276_abnormal_autonomic_nervous1.03631950
82MP0000604_amyloidosis1.02038365
83MP0001664_abnormal_digestion1.01701168
84MP0001440_abnormal_grooming_behavior1.01298628
85MP0005330_cardiomyopathy1.01078998
86MP0004085_abnormal_heartbeat0.99458997
87MP0009764_decreased_sensitivity_to0.99083573
88MP0003011_delayed_dark_adaptation0.97421814
89MP0002733_abnormal_thermal_nociception0.97112760
90MP0009763_increased_sensitivity_to0.95048519
91MP0002572_abnormal_emotion/affect_behav0.94713933
92MP0001963_abnormal_hearing_physiology0.94676421
93MP0002063_abnormal_learning/memory/cond0.93574124
94MP0001970_abnormal_pain_threshold0.93455459
95MP0003938_abnormal_ear_development0.91720342
96MP0003137_abnormal_impulse_conducting0.91216034
97MP0004185_abnormal_adipocyte_glucose0.90914468
98MP0004084_abnormal_cardiac_muscle0.90226160
99MP0000015_abnormal_ear_pigmentation0.90082473
100MP0009384_cardiac_valve_regurgitation0.89652204
101MP0005636_abnormal_mineral_homeostasis0.89601218
102MP0002638_abnormal_pupillary_reflex0.89279245
103MP0002078_abnormal_glucose_homeostasis0.89231007
104MP0005334_abnormal_fat_pad0.88590160
105MP0004036_abnormal_muscle_relaxation0.88072454
106MP0008469_abnormal_protein_level0.87528365
107MP0009697_abnormal_copulation0.86756045
108MP0002734_abnormal_mechanical_nocicepti0.85586164
109MP0005647_abnormal_sex_gland0.85357410
110MP0005187_abnormal_penis_morphology0.85226311
111MP0004484_altered_response_of0.84055492
112MP0000613_abnormal_salivary_gland0.83254962
113MP0005084_abnormal_gallbladder_morpholo0.83060785
114MP0009642_abnormal_blood_homeostasis0.82892230
115MP0001919_abnormal_reproductive_system0.82888912
116MP0004270_analgesia0.82250365
117MP0005535_abnormal_body_temperature0.82126837
118MP0002067_abnormal_sensory_capabilities0.81953178
119MP0002693_abnormal_pancreas_physiology0.81061854
120MP0008995_early_reproductive_senescence0.80672183
121MP0002557_abnormal_social/conspecific_i0.80659768
122MP0010386_abnormal_urinary_bladder0.79434343
123MP0001984_abnormal_olfaction0.78275432
124MP0005410_abnormal_fertilization0.77843841
125MP0004147_increased_porphyrin_level0.76915229
126MP0001661_extended_life_span0.76806458
127MP0001756_abnormal_urination0.76385412
128MP0003329_amyloid_beta_deposits0.76232232
129MP0003690_abnormal_glial_cell0.76031418
130MP0003300_gastrointestinal_ulcer0.75401463
131MP0002229_neurodegeneration0.75366783
132MP0004134_abnormal_chest_morphology0.75064947
133MP0010678_abnormal_skin_adnexa0.74979204
134MP0003646_muscle_fatigue0.73525382
135MP0005058_abnormal_lysosome_morphology0.73342594
136MP0005375_adipose_tissue_phenotype0.72670704
137MP0003724_increased_susceptibility_to0.72387144
138MP0005275_abnormal_skin_tensile0.72242319
139MP0000049_abnormal_middle_ear0.72038960
140MP0005075_abnormal_melanosome_morpholog0.70945564
141MP0001944_abnormal_pancreas_morphology0.70046678
142MP0003279_aneurysm0.68507227
143MP0004087_abnormal_muscle_fiber0.68467419
144MP0005220_abnormal_exocrine_pancreas0.68181122
145MP0001544_abnormal_cardiovascular_syste0.65865976
146MP0005385_cardiovascular_system_phenoty0.65865976
147MP0005376_homeostasis/metabolism_phenot0.64748966
148MP0000749_muscle_degeneration0.63584246
149MP0000751_myopathy0.62982566
150MP0005408_hypopigmentation0.62522005
151MP0002269_muscular_atrophy0.62277557
152MP0002136_abnormal_kidney_physiology0.62030741
153MP0008775_abnormal_heart_ventricle0.61980637
154MP0010630_abnormal_cardiac_muscle0.61318223
155MP0005448_abnormal_energy_balance0.61067017
156MP0005266_abnormal_metabolism0.59731748
157MP0002254_reproductive_system_inflammat0.58969444
158MP0009115_abnormal_fat_cell0.58156163
159MP0009053_abnormal_anal_canal0.57212700
160MP0000230_abnormal_systemic_arterial0.57201644
161MP0006035_abnormal_mitochondrial_morpho0.57139626
162MP0003075_altered_response_to0.57097717
163MP0005464_abnormal_platelet_physiology0.56972675
164MP0002972_abnormal_cardiac_muscle0.56255095
165MP0004043_abnormal_pH_regulation0.55584832
166MP0006138_congestive_heart_failure0.55252029
167MP0000249_abnormal_blood_vessel0.54649390
168MP0005165_increased_susceptibility_to0.53954275
169MP0009765_abnormal_xenobiotic_induced0.53121043
170MP0000747_muscle_weakness0.52865344
171MP0003566_abnormal_cell_adhesion0.52153493
172MP0003436_decreased_susceptibility_to0.51677720
173MP0002970_abnormal_white_adipose0.49819712
174MP0008961_abnormal_basal_metabolism0.49398275
175MP0002168_other_aberrant_phenotype0.49068547
176MP0005166_decreased_susceptibility_to0.48527344
177MP0005167_abnormal_blood-brain_barrier0.48453382

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.16235161
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.98414222
3Intrahepatic cholestasis (HP:0001406)5.81031751
4Xanthomatosis (HP:0000991)5.44122672
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.11943735
6Hyperlipoproteinemia (HP:0010980)4.82024488
7Prolonged partial thromboplastin time (HP:0003645)4.78610914
8Hypoglycemic coma (HP:0001325)4.65683351
9Hypobetalipoproteinemia (HP:0003563)4.64230774
10Hyperammonemia (HP:0001987)4.43196071
11Ketosis (HP:0001946)4.39255671
12Complement deficiency (HP:0004431)4.24328708
13Hyperglycinuria (HP:0003108)3.94277109
14Abnormality of fatty-acid metabolism (HP:0004359)3.93444393
15Hypolipoproteinemia (HP:0010981)3.85006773
16Abnormality of glycine metabolism (HP:0010895)3.82732798
17Abnormality of serine family amino acid metabolism (HP:0010894)3.82732798
18Hyperglycinemia (HP:0002154)3.76629543
19Short 1st metacarpal (HP:0010034)3.72883989
20Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.72883989
21Abnormality of the renal cortex (HP:0011035)3.71848049
22Hypoalphalipoproteinemia (HP:0003233)3.71336338
23Ketoacidosis (HP:0001993)3.69445117
24Abnormality of the common coagulation pathway (HP:0010990)3.67416512
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.65675742
26Abnormality of glutamine family amino acid metabolism (HP:0010902)3.61691397
27Joint hemorrhage (HP:0005261)3.60341338
28Epidermoid cyst (HP:0200040)3.58783282
29Pancreatic cysts (HP:0001737)3.56594010
30Congenital stationary night blindness (HP:0007642)3.54206956
31Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.50482427
32Abnormality of sulfur amino acid metabolism (HP:0004339)3.37485810
33Abnormality of aspartate family amino acid metabolism (HP:0010899)3.32351610
34Abnormality of the 1st metacarpal (HP:0010009)3.32336902
35Abnormality of the intrinsic pathway (HP:0010989)3.22696687
36Morphological abnormality of the middle ear (HP:0008609)3.20038899
37Fat malabsorption (HP:0002630)3.19659039
38Gaze-evoked nystagmus (HP:0000640)3.13265847
39Abnormality of methionine metabolism (HP:0010901)3.12224014
40Abnormality of complement system (HP:0005339)3.11543115
41Dicarboxylic aciduria (HP:0003215)3.09336869
42Abnormality of dicarboxylic acid metabolism (HP:0010995)3.09336869
43Pancreatic fibrosis (HP:0100732)3.01192810
44Hyperventilation (HP:0002883)3.00969923
45True hermaphroditism (HP:0010459)2.98366183
46Nephronophthisis (HP:0000090)2.97943193
47Hypercholesterolemia (HP:0003124)2.97917346
48Congenital sensorineural hearing impairment (HP:0008527)2.97027630
49Abnormality of the nasal septum (HP:0000419)2.90984888
50Large for gestational age (HP:0001520)2.90497111
51Absent phalangeal crease (HP:0006109)2.90456473
52Methylmalonic acidemia (HP:0002912)2.84155304
53Hyperbilirubinemia (HP:0002904)2.77744415
54Molar tooth sign on MRI (HP:0002419)2.77054134
55Abnormality of midbrain morphology (HP:0002418)2.77054134
56Abnormality of the renal medulla (HP:0100957)2.76457898
57Skin nodule (HP:0200036)2.75498215
58Myocardial infarction (HP:0001658)2.72807534
59Increased corneal curvature (HP:0100692)2.71995209
60Keratoconus (HP:0000563)2.71995209
61Myoglobinuria (HP:0002913)2.70418797
62Metabolic acidosis (HP:0001942)2.70305248
63Generalized aminoaciduria (HP:0002909)2.68392521
64Attenuation of retinal blood vessels (HP:0007843)2.65271028
65Delayed CNS myelination (HP:0002188)2.65032713
66Hypoplasia of the fovea (HP:0007750)2.64503130
67Aplasia/Hypoplasia of the fovea (HP:0008060)2.64503130
68Hepatocellular carcinoma (HP:0001402)2.64273422
69Abnormality of purine metabolism (HP:0004352)2.64006367
70Abolished electroretinogram (ERG) (HP:0000550)2.63055914
71Abnormality of the proximal phalanges of the hand (HP:0009834)2.62382622
72Abnormality of serum amino acid levels (HP:0003112)2.59437996
73Progressive cerebellar ataxia (HP:0002073)2.57243280
74Short hallux (HP:0010109)2.55675295
75Febrile seizures (HP:0002373)2.55433014
76Abnormal finger flexion creases (HP:0006143)2.54292266
77Aplasia/Hypoplasia of the tibia (HP:0005772)2.52604692
78Aplasia/Hypoplasia of the hallux (HP:0008362)2.52367114
79Hypoglycemic seizures (HP:0002173)2.51538501
80Abnormality of nucleobase metabolism (HP:0010932)2.50431118
81Broad-based gait (HP:0002136)2.50002585
82Pendular nystagmus (HP:0012043)2.46424835
83Gout (HP:0001997)2.45964186
84Lethargy (HP:0001254)2.43660839
85Conjugated hyperbilirubinemia (HP:0002908)2.41702387
86Short phalanx of the thumb (HP:0009660)2.41248753
87Abnormal gallbladder morphology (HP:0012437)2.40501985
88Genetic anticipation (HP:0003743)2.40459431
89Steatorrhea (HP:0002570)2.39241800
90Cholelithiasis (HP:0001081)2.38746638
91Cerebral edema (HP:0002181)2.38726430
92Asplenia (HP:0001746)2.37979698
93Hemiparesis (HP:0001269)2.36783381
94Chorioretinal atrophy (HP:0000533)2.34463251
95Tubular atrophy (HP:0000092)2.33878284
96Symphalangism affecting the phalanges of the hand (HP:0009773)2.32422147
97Hyperinsulinemic hypoglycemia (HP:0000825)2.30750296
98Methylmalonic aciduria (HP:0012120)2.30566189
99Decreased circulating renin level (HP:0003351)2.30531947
100Mitral stenosis (HP:0001718)2.30457828
101Aplasia/Hypoplasia of the spleen (HP:0010451)2.29860622
102Esophageal varix (HP:0002040)2.27019154
103Abnormal drinking behavior (HP:0030082)2.25768815
104Polydipsia (HP:0001959)2.25768815
105Focal motor seizures (HP:0011153)2.25348218
106Late onset (HP:0003584)2.24078744
107Systemic lupus erythematosus (HP:0002725)2.23927839
108Abnormality of pyrimidine metabolism (HP:0004353)2.23280620
109Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.22350986
110Vascular calcification (HP:0004934)2.21894026
111Spastic diplegia (HP:0001264)2.21585409
112Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.21569468
113Abnormality of alanine metabolism (HP:0010916)2.21569468
114Hyperalaninemia (HP:0003348)2.21569468
115Abnormal gallbladder physiology (HP:0012438)2.21483050
116Cholecystitis (HP:0001082)2.21483050
117Congenital, generalized hypertrichosis (HP:0004540)2.20656407
118Abnormal cartilage morphology (HP:0002763)2.19053952
119Bilateral microphthalmos (HP:0007633)2.18305609
120Vomiting (HP:0002013)2.15646385
121Medial flaring of the eyebrow (HP:0010747)2.14575817
122Clumsiness (HP:0002312)2.14251916
123Agitation (HP:0000713)2.13915104
124Amyloidosis (HP:0011034)2.13844121
125Rhabdomyolysis (HP:0003201)2.13816346
126Abnormal rod and cone electroretinograms (HP:0008323)2.13286285
127Aplasia/Hypoplasia of the sternum (HP:0006714)2.12815249
128Sensorimotor neuropathy (HP:0007141)2.12702239
129Thyroiditis (HP:0100646)2.12540570
130Cardiovascular calcification (HP:0011915)2.12226183
131Thyroid-stimulating hormone excess (HP:0002925)2.11448539
132Cystic liver disease (HP:0006706)2.11342377
133Absent rod-and cone-mediated responses on ERG (HP:0007688)2.11018380
134Short tibia (HP:0005736)2.09637190
135Neonatal onset (HP:0003623)2.08429390
136Hydroxyprolinuria (HP:0003080)2.07795950
137Abnormality of proline metabolism (HP:0010907)2.07795950
138Nausea (HP:0002018)2.07402775
139Abnormality of the fovea (HP:0000493)2.07284217
140Proximal tubulopathy (HP:0000114)2.04612976
141Right ventricular cardiomyopathy (HP:0011663)2.04264233
142Pancreatitis (HP:0001733)2.03421219
143Focal seizures (HP:0007359)2.02892044
144Decreased central vision (HP:0007663)2.02808668
145Abnormality of vitamin B metabolism (HP:0004340)2.00395217
146Progressive inability to walk (HP:0002505)2.00133178
147Metabolic alkalosis (HP:0200114)1.99779158
148Stomach cancer (HP:0012126)1.98063557
149Abnormality of the middle phalanges of the toes (HP:0010183)1.97198655
150Spontaneous abortion (HP:0005268)1.96516116
151Syncope (HP:0001279)1.95172642
152Hyperglycemia (HP:0003074)1.94998858
153Decreased electroretinogram (ERG) amplitude (HP:0000654)1.94812990
154Muscle hypertrophy of the lower extremities (HP:0008968)1.92737488
155Abnormality of the gallbladder (HP:0005264)1.92214182
156Type II lissencephaly (HP:0007260)1.92086020
157Abnormality of the phalanges of the 5th finger (HP:0004213)1.91679678
158Prostate neoplasm (HP:0100787)1.89668487
159Hemorrhage of the eye (HP:0011885)1.89655759
160Polycythemia (HP:0001901)1.88823452
161Axonal loss (HP:0003447)1.87789928
162Calf muscle hypertrophy (HP:0008981)1.87489706
163Abnormality of the renal collecting system (HP:0004742)1.86942570
164Glomerulonephritis (HP:0000099)1.86767107
165Irritability (HP:0000737)1.86594143
166Absent speech (HP:0001344)1.86166901
167Renal cortical cysts (HP:0000803)1.85860199
168Malnutrition (HP:0004395)1.85509417
169Abnormality of the vitamin B12 metabolism (HP:0004341)1.83843310
170Tented upper lip vermilion (HP:0010804)1.83607115
171Recurrent gram-negative bacterial infections (HP:0005420)1.81017392
172Menorrhagia (HP:0000132)1.80748132
173Abnormality of urine glucose concentration (HP:0011016)1.77852229
174Glycosuria (HP:0003076)1.77852229
175Abnormality of iron homeostasis (HP:0011031)1.77343635
176Inability to walk (HP:0002540)1.77332858
177Increased purine levels (HP:0004368)1.77315761
178Hyperuricemia (HP:0002149)1.77315761
179Congenital hepatic fibrosis (HP:0002612)1.76431991
180Tachypnea (HP:0002789)1.75712236
181Bony spicule pigmentary retinopathy (HP:0007737)1.75638252
182Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.75264039
183Increased muscle lipid content (HP:0009058)1.75004688
184Chronic hepatic failure (HP:0100626)1.74925871
185Furrowed tongue (HP:0000221)1.74723834
186Acanthocytosis (HP:0001927)1.74632122
187Hepatic necrosis (HP:0002605)1.74428671
188Exercise-induced myalgia (HP:0003738)1.74128288
189Hypertriglyceridemia (HP:0002155)1.73699186
190Abnormality of transition element cation homeostasis (HP:0011030)1.73197312
191Goiter (HP:0000853)1.72153232
192Absent/shortened dynein arms (HP:0200106)1.71291863
193Dynein arm defect of respiratory motile cilia (HP:0012255)1.71291863
194Male pseudohermaphroditism (HP:0000037)1.70531268
195Hemiplegia (HP:0002301)1.70456776
196Polyuria (HP:0000103)1.70363896
197Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.69708334

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.27410363
2ERN14.16362034
3TRIB34.03600688
4PKN23.42437240
5SIK13.38094566
6FGFR42.91447594
7GRK12.76228357
8INSRR2.61329519
9TAOK32.58084801
10ACVR1B2.52662230
11ADRBK22.35530786
12MAPK132.31654103
13TTN2.25472430
14BMPR1B2.12930247
15TXK2.08996471
16NUAK12.04026686
17FLT32.01111820
18MAP4K22.00495749
19PTK61.96144775
20EPHB11.80868453
21WNK31.78009740
22MST1R1.64536201
23TLK11.61347987
24STK391.52609020
25OXSR11.52301618
26CASK1.49251222
27MARK11.46486257
28NEK91.46074713
29RIPK11.41732979
30NTRK31.41180928
31KDR1.40433920
32TEC1.38045232
33PDK41.35539724
34PDK31.35539724
35TYK21.34778045
36PLK21.33466047
37PIK3CG1.29536938
38ZAK1.26878493
39MAP3K71.26159094
40MYLK1.23637096
41EIF2AK31.23472066
42MAP3K101.21281462
43MAP2K31.21030361
44TIE11.18075260
45MET1.16676504
46PDGFRA1.16301108
47ERBB41.15218602
48TGFBR21.14864661
49LATS11.13989910
50CAMK1D1.13202928
51TNIK1.11798776
52JAK11.09522425
53MAP2K41.09131316
54MAPKAPK31.06975952
55TBK11.06917593
56LRRK21.06222187
57MAPK111.05236505
58MAP2K61.05037389
59LMTK21.03403081
60GRK71.00508900
61PRKAA20.99784583
62JAK20.98000822
63ADRBK10.96125334
64GRK50.92885488
65MAP3K40.89869235
66SGK20.89610155
67ITK0.88986606
68MAP3K30.87505415
69ERBB30.86797645
70ABL20.86766125
71WNK40.86464356
72RET0.85940455
73AKT30.80899996
74PHKG20.80200926
75PHKG10.80200926
76FGFR20.78581620
77PTK20.78232527
78EEF2K0.78145570
79NLK0.77061027
80FRK0.76660215
81MAPK120.76002771
82CAMK1G0.75113091
83PIK3CA0.75111969
84PAK30.74609785
85CSK0.74364874
86PRKD10.74241084
87PDK20.73419567
88PDPK10.72751238
89MAP3K90.71840307
90MAP2K10.71630365
91PRKCE0.71624765
92CSNK1G20.70476003
93MAPKAPK50.69748542
94ABL10.68067920
95TNK20.68054204
96EPHA30.66888633
97CDK60.65780476
98SYK0.64433959
99MAP2K20.64076474
100PRKCG0.64032910
101CAMKK20.63950216
102TRPM70.63441736
103PINK10.63042228
104PLK40.62702291
105CSNK1G10.62698000
106PAK20.61633284
107BMX0.60928037
108NTRK20.60827559
109MAP3K50.57863814
110CAMK2A0.57861161
111FGFR30.57822037
112KSR20.57428451
113OBSCN0.57047656
114GSK3A0.54955763
115DYRK1B0.54660722
116MAP3K110.54445757
117MUSK0.53509269
118CSNK1G30.53432855
119PRKACA0.53210834
120ERBB20.53035376
121PAK60.51893328
122PRKACG0.51810919
123STK110.51318271
124STK30.51278971
125MAPK40.51005023
126MAP3K10.50082068
127TRIM280.50035451
128PKN10.49817401
129PDK10.49090736
130EPHB20.48958452
131MAP3K20.48277190
132SGK10.47985405
133MAP4K10.47913698
134CSNK1A1L0.47463072
135IRAK30.47376724
136DMPK0.47302595
137PRKCH0.46652429
138DAPK20.46451603
139PRKAA10.46410465
140FER0.46102291
141STK240.45415344
142KIT0.44974493
143MTOR0.42951875
144ZAP700.42794619
145EPHA40.42198403
146STK38L0.42022355
147GRK60.42015004
148PDGFRB0.41715605
149PRKG10.41696979
150CAMK40.41471058
151ICK0.41153861
152CCNB10.40777602
153CSNK1A10.40385685
154IKBKB0.40163016
155SGK2230.39106520
156SGK4940.39106520
157PRKG20.38659225
158PRKCQ0.38404377
159IGF1R0.38335340
160PRKCA0.37444146
161MAPK30.37287943
162IKBKE0.37023105
163CAMK2D0.36862127
164PTK2B0.35385090
165JAK30.35277711
166RAF10.35271376
167CAMK10.35173408
168NME10.34717422
169FGFR10.34694809
170RPS6KA30.34672368
171CAMK2G0.34192128
172CAMKK10.33032952
173EIF2AK20.31833324

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.87160207
2Nitrogen metabolism_Homo sapiens_hsa009103.24590377
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.17362077
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.08575950
5Fatty acid degradation_Homo sapiens_hsa000713.01066963
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.82041366
7Arginine biosynthesis_Homo sapiens_hsa002202.69636287
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.69387717
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.68598541
10Tryptophan metabolism_Homo sapiens_hsa003802.61333205
11Propanoate metabolism_Homo sapiens_hsa006402.57667131
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.55072585
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.53343978
14Complement and coagulation cascades_Homo sapiens_hsa046102.30161127
15Phototransduction_Homo sapiens_hsa047442.29894299
16Fatty acid metabolism_Homo sapiens_hsa012122.26554458
17Butanoate metabolism_Homo sapiens_hsa006502.21882159
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.15564627
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.13234428
20Pentose and glucuronate interconversions_Homo sapiens_hsa000402.12503691
21PPAR signaling pathway_Homo sapiens_hsa033202.10821184
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.10697287
23Nicotine addiction_Homo sapiens_hsa050332.06874274
24Peroxisome_Homo sapiens_hsa041462.01358760
25Caffeine metabolism_Homo sapiens_hsa002321.96773500
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.92474760
27Insulin secretion_Homo sapiens_hsa049111.82482338
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.76692469
29beta-Alanine metabolism_Homo sapiens_hsa004101.74272518
30Chemical carcinogenesis_Homo sapiens_hsa052041.73411406
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.73391349
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.70755691
33Histidine metabolism_Homo sapiens_hsa003401.70407822
34Pyruvate metabolism_Homo sapiens_hsa006201.70223868
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.64519716
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64307503
37Dorso-ventral axis formation_Homo sapiens_hsa043201.59347293
38Morphine addiction_Homo sapiens_hsa050321.59280909
39Circadian entrainment_Homo sapiens_hsa047131.57129807
40Sulfur metabolism_Homo sapiens_hsa009201.56749035
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.55684098
42Fatty acid elongation_Homo sapiens_hsa000621.54259142
43Carbon metabolism_Homo sapiens_hsa012001.50105467
44Staphylococcus aureus infection_Homo sapiens_hsa051501.48694217
45Salivary secretion_Homo sapiens_hsa049701.46576436
46Bile secretion_Homo sapiens_hsa049761.45535034
47Retinol metabolism_Homo sapiens_hsa008301.42217702
48Olfactory transduction_Homo sapiens_hsa047401.41910431
49Taste transduction_Homo sapiens_hsa047421.41308033
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39171349
51Starch and sucrose metabolism_Homo sapiens_hsa005001.38129141
52Drug metabolism - other enzymes_Homo sapiens_hsa009831.36984531
53Phenylalanine metabolism_Homo sapiens_hsa003601.36525073
54Calcium signaling pathway_Homo sapiens_hsa040201.29900098
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27680695
56Ether lipid metabolism_Homo sapiens_hsa005651.25904296
57Glutamatergic synapse_Homo sapiens_hsa047241.24167454
58Intestinal immune network for IgA production_Homo sapiens_hsa046721.23986417
59Selenocompound metabolism_Homo sapiens_hsa004501.23209544
60Serotonergic synapse_Homo sapiens_hsa047261.22921300
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20318710
62Tyrosine metabolism_Homo sapiens_hsa003501.19552651
63Fat digestion and absorption_Homo sapiens_hsa049751.18935252
64RNA degradation_Homo sapiens_hsa030181.18692687
65Biosynthesis of amino acids_Homo sapiens_hsa012301.18240977
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17966044
67Renin secretion_Homo sapiens_hsa049241.15938296
68GABAergic synapse_Homo sapiens_hsa047271.11927854
69Cysteine and methionine metabolism_Homo sapiens_hsa002701.08460059
70ABC transporters_Homo sapiens_hsa020101.06228878
71Gastric acid secretion_Homo sapiens_hsa049711.04444448
72Regulation of autophagy_Homo sapiens_hsa041401.04403225
73Steroid biosynthesis_Homo sapiens_hsa001000.99932115
74Folate biosynthesis_Homo sapiens_hsa007900.99069504
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96949893
76Arginine and proline metabolism_Homo sapiens_hsa003300.93724209
77Sulfur relay system_Homo sapiens_hsa041220.93370990
78Amphetamine addiction_Homo sapiens_hsa050310.91763517
79Lysine degradation_Homo sapiens_hsa003100.91068187
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89789674
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86851342
82Asthma_Homo sapiens_hsa053100.86135270
83Arachidonic acid metabolism_Homo sapiens_hsa005900.84055357
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81539341
85Primary immunodeficiency_Homo sapiens_hsa053400.81308912
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.80984828
87Cholinergic synapse_Homo sapiens_hsa047250.80104239
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.79945551
89Homologous recombination_Homo sapiens_hsa034400.78117735
90cAMP signaling pathway_Homo sapiens_hsa040240.77714691
91Type I diabetes mellitus_Homo sapiens_hsa049400.77263905
92Fatty acid biosynthesis_Homo sapiens_hsa000610.77230637
93Glycerolipid metabolism_Homo sapiens_hsa005610.76619309
94Dopaminergic synapse_Homo sapiens_hsa047280.74907079
95Oxytocin signaling pathway_Homo sapiens_hsa049210.74784836
96Cardiac muscle contraction_Homo sapiens_hsa042600.74401002
97Pancreatic secretion_Homo sapiens_hsa049720.74291096
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.72214816
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70562461
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70455857
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68948520
102Long-term depression_Homo sapiens_hsa047300.68038610
103Circadian rhythm_Homo sapiens_hsa047100.67588473
104Glutathione metabolism_Homo sapiens_hsa004800.66586793
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66401363
106Vitamin digestion and absorption_Homo sapiens_hsa049770.62002572
107Basal transcription factors_Homo sapiens_hsa030220.60059096
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60005822
109Pentose phosphate pathway_Homo sapiens_hsa000300.59837238
110Fanconi anemia pathway_Homo sapiens_hsa034600.59531026
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59011316
112Mineral absorption_Homo sapiens_hsa049780.56476604
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.55997543
114Insulin resistance_Homo sapiens_hsa049310.53924268
115Protein export_Homo sapiens_hsa030600.50421934
116Cocaine addiction_Homo sapiens_hsa050300.49133744
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44747113
118Long-term potentiation_Homo sapiens_hsa047200.41431513
119Graft-versus-host disease_Homo sapiens_hsa053320.41124559
120Metabolic pathways_Homo sapiens_hsa011000.40187912
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39809791
122Autoimmune thyroid disease_Homo sapiens_hsa053200.39501372
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35984705
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34519814
125Vitamin B6 metabolism_Homo sapiens_hsa007500.32921476
126Allograft rejection_Homo sapiens_hsa053300.32529214
127Galactose metabolism_Homo sapiens_hsa000520.28924757
128Prion diseases_Homo sapiens_hsa050200.28772766
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25058911
130AMPK signaling pathway_Homo sapiens_hsa041520.25006074
131Glucagon signaling pathway_Homo sapiens_hsa049220.22617248
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19059576
133Fructose and mannose metabolism_Homo sapiens_hsa000510.18925247
134One carbon pool by folate_Homo sapiens_hsa006700.18784476
135Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16838888
136Linoleic acid metabolism_Homo sapiens_hsa005910.15240570
137Insulin signaling pathway_Homo sapiens_hsa049100.14675018
138Ovarian steroidogenesis_Homo sapiens_hsa049130.10214105
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.08908050
140Central carbon metabolism in cancer_Homo sapiens_hsa052300.03556265
141Amoebiasis_Homo sapiens_hsa051460.01571712
142Type II diabetes mellitus_Homo sapiens_hsa04930-0.1061740
143Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1041464
144Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0991165
145Oxidative phosphorylation_Homo sapiens_hsa00190-0.0977839
146ECM-receptor interaction_Homo sapiens_hsa04512-0.0950069
147Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0773807
148Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0737337
149Alzheimers disease_Homo sapiens_hsa05010-0.0716144
150Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410-0.0680568
151Lysosome_Homo sapiens_hsa04142-0.0673184
152Protein digestion and absorption_Homo sapiens_hsa04974-0.0634640
153Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0633390
154Parkinsons disease_Homo sapiens_hsa05012-0.0614544
155Dilated cardiomyopathy_Homo sapiens_hsa05414-0.0607217
156Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0220663
157Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0190474

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