YWHAZP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.56929913
2sequestering of actin monomers (GO:0042989)5.27828455
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.09980822
4platelet dense granule organization (GO:0060155)5.00364868
5protein neddylation (GO:0045116)4.85183529
6proteasome assembly (GO:0043248)4.74579795
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.03558753
8fucose catabolic process (GO:0019317)3.85217508
9L-fucose metabolic process (GO:0042354)3.85217508
10L-fucose catabolic process (GO:0042355)3.85217508
11water-soluble vitamin biosynthetic process (GO:0042364)3.79611318
12cullin deneddylation (GO:0010388)3.68103856
13cytidine deamination (GO:0009972)3.67876750
14cytidine metabolic process (GO:0046087)3.67876750
15cytidine catabolic process (GO:0006216)3.67876750
16protein deneddylation (GO:0000338)3.65492392
17respiratory chain complex IV assembly (GO:0008535)3.60421009
18behavioral response to nicotine (GO:0035095)3.60277358
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.49338044
20energy coupled proton transport, down electrochemical gradient (GO:0015985)3.47553217
21ATP synthesis coupled proton transport (GO:0015986)3.47553217
22L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.41290516
23cytochrome complex assembly (GO:0017004)3.30080164
24piRNA metabolic process (GO:0034587)3.25916130
25tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.21469153
26RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.21469153
27positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.17529378
28pyrimidine ribonucleoside catabolic process (GO:0046133)3.16003708
29positive regulation of prostaglandin secretion (GO:0032308)3.14465926
30RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.11533432
31negative regulation of synaptic transmission, GABAergic (GO:0032229)3.10987218
32positive regulation of mitochondrial fission (GO:0090141)3.09259413
33mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.06327609
34regulation of cellular amino acid metabolic process (GO:0006521)3.04537189
35retinal cone cell development (GO:0046549)2.98309829
36protein complex biogenesis (GO:0070271)2.95708525
37amino acid salvage (GO:0043102)2.95480804
38L-methionine salvage (GO:0071267)2.95480804
39L-methionine biosynthetic process (GO:0071265)2.95480804
40metallo-sulfur cluster assembly (GO:0031163)2.95214916
41iron-sulfur cluster assembly (GO:0016226)2.95214916
42regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.93974908
43response to pheromone (GO:0019236)2.93265421
44positive regulation of defense response to virus by host (GO:0002230)2.92556730
45regulation of isotype switching to IgG isotypes (GO:0048302)2.92513990
46signal peptide processing (GO:0006465)2.89568024
47negative regulation of telomere maintenance (GO:0032205)2.89395903
48indolalkylamine metabolic process (GO:0006586)2.85276925
49negative regulation of heart rate (GO:0010459)2.85248651
50mannosylation (GO:0097502)2.81081219
51GMP metabolic process (GO:0046037)2.80466744
52nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.77405327
53exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.73569122
54protein-cofactor linkage (GO:0018065)2.69805009
55DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.69620999
56mitochondrial respiratory chain complex assembly (GO:0033108)2.65526249
57regulation of cilium movement (GO:0003352)2.65317160
58signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.61899098
59signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.61899098
60signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.61899098
61negative regulation of calcium ion transport into cytosol (GO:0010523)2.60627030
62gamma-aminobutyric acid transport (GO:0015812)2.59707695
63S-adenosylmethionine metabolic process (GO:0046500)2.58412287
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.58272801
65intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.58272801
66proton transport (GO:0015992)2.58191181
67tryptophan metabolic process (GO:0006568)2.56928989
68electron transport chain (GO:0022900)2.56177794
69regulation of prostaglandin secretion (GO:0032306)2.55848100
70branched-chain amino acid catabolic process (GO:0009083)2.55823744
71positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.54532638
72DNA double-strand break processing (GO:0000729)2.52433430
73tRNA processing (GO:0008033)2.52273858
74negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.51841132
75Arp2/3 complex-mediated actin nucleation (GO:0034314)2.51474735
76mismatch repair (GO:0006298)2.51377464
77mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.50921763
78mitochondrial respiratory chain complex I assembly (GO:0032981)2.50921763
79NADH dehydrogenase complex assembly (GO:0010257)2.50921763
80regulation of regulatory T cell differentiation (GO:0045589)2.50583506
81hydrogen transport (GO:0006818)2.50102210
82regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.50036596
83regulation of mitotic spindle checkpoint (GO:1903504)2.50036596
84respiratory electron transport chain (GO:0022904)2.49685369
85hydrogen ion transmembrane transport (GO:1902600)2.49388164
86multicellular organism reproduction (GO:0032504)2.49272019
87inositol phosphate catabolic process (GO:0071545)2.49150694
88protein polyglutamylation (GO:0018095)2.48304581
89phosphorylated carbohydrate dephosphorylation (GO:0046838)2.47327808
90inositol phosphate dephosphorylation (GO:0046855)2.47327808
91regulation of mitochondrial fission (GO:0090140)2.46738702
92regulation of rhodopsin mediated signaling pathway (GO:0022400)2.46622723
93detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.45492488
94regulation of memory T cell differentiation (GO:0043380)2.45075445
95signal transduction involved in cell cycle checkpoint (GO:0072395)2.44599017
96positive regulation of interleukin-17 production (GO:0032740)2.44097748
97protein targeting to mitochondrion (GO:0006626)2.44021620
98establishment of protein localization to mitochondrion (GO:0072655)2.43960028
99anterograde synaptic vesicle transport (GO:0048490)2.42633934
100signal transduction involved in DNA integrity checkpoint (GO:0072401)2.42304511

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.69366539
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.65308335
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.47447017
4ZNF274_21170338_ChIP-Seq_K562_Hela3.24299584
5VDR_22108803_ChIP-Seq_LS180_Human3.09300834
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.72354166
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.69239499
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.63093949
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.60389026
10IGF1R_20145208_ChIP-Seq_DFB_Human2.46878432
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36833190
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.35987343
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.32334956
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.30896044
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.29587148
16VDR_23849224_ChIP-Seq_CD4+_Human2.26011208
17ELK1_19687146_ChIP-ChIP_HELA_Human2.18465584
18TAF15_26573619_Chip-Seq_HEK293_Human2.07690850
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.07397410
20EWS_26573619_Chip-Seq_HEK293_Human2.05475987
21GBX2_23144817_ChIP-Seq_PC3_Human2.04730124
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.03504031
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89478901
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.74247734
25P300_19829295_ChIP-Seq_ESCs_Human1.74022941
26ER_23166858_ChIP-Seq_MCF-7_Human1.73294204
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.70515571
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.70086638
29FOXP3_21729870_ChIP-Seq_TREG_Human1.64366435
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.64111430
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62189433
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.61433051
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.61003563
34MYC_18940864_ChIP-ChIP_HL60_Human1.60427502
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59204572
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56045694
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54355280
38TP53_22573176_ChIP-Seq_HFKS_Human1.48143789
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.42201087
40STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.41955328
41SOX2_19829295_ChIP-Seq_ESCs_Human1.40884181
42NANOG_19829295_ChIP-Seq_ESCs_Human1.40884181
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40067005
44CBP_20019798_ChIP-Seq_JUKART_Human1.40067005
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38954620
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.38948951
47FUS_26573619_Chip-Seq_HEK293_Human1.38406108
48AUTS2_25519132_ChIP-Seq_293T-REX_Human1.36071601
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35085524
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34826016
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.33628671
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.31402351
53AR_20517297_ChIP-Seq_VCAP_Human1.31324743
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.31049996
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31049996
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.30847351
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.30110428
58GATA3_26560356_Chip-Seq_TH2_Human1.26276927
59BCAT_22108803_ChIP-Seq_LS180_Human1.26267420
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24911175
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24785710
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24666315
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23018276
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20025129
65FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.16234572
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14693656
67NCOR_22424771_ChIP-Seq_293T_Human1.12251538
68CRX_20693478_ChIP-Seq_RETINA_Mouse1.12206405
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11946051
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10455644
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09049923
72TCF4_22108803_ChIP-Seq_LS180_Human1.08579825
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06452239
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06401633
75IRF1_19129219_ChIP-ChIP_H3396_Human1.05019697
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02983504
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02853110
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02346210
79FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01775365
80ELK1_22589737_ChIP-Seq_MCF10A_Human1.01694235
81PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98299133
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97422186
83EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97247390
84SMAD4_21799915_ChIP-Seq_A2780_Human0.96899015
85PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.96083021
86TAL1_26923725_Chip-Seq_HPCs_Mouse0.95750538
87GABP_19822575_ChIP-Seq_HepG2_Human0.95568432
88KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95307491
89ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93674217
90CDX2_22108803_ChIP-Seq_LS180_Human0.93001714
91STAT3_18555785_Chip-Seq_ESCs_Mouse0.92166731
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92132369
93SMAD3_21741376_ChIP-Seq_EPCs_Human0.91855566
94SMAD_19615063_ChIP-ChIP_OVARY_Human0.90805200
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90367077
96IRF8_21731497_ChIP-ChIP_J774_Mouse0.89995553
97SALL4_22934838_ChIP-ChIP_CD34+_Human0.89892547
98MYC_19829295_ChIP-Seq_ESCs_Human0.89620771
99FOXH1_21741376_ChIP-Seq_EPCs_Human0.89481793
100CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89153280

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005084_abnormal_gallbladder_morpholo3.48724155
2MP0002102_abnormal_ear_morphology3.38445212
3MP0005671_abnormal_response_to3.15235092
4MP0003880_abnormal_central_pattern3.00090271
5MP0002736_abnormal_nociception_after2.80400943
6MP0002138_abnormal_hepatobiliary_system2.69376516
7MP0001529_abnormal_vocalization2.52611565
8MP0008877_abnormal_DNA_methylation2.51110942
9MP0001968_abnormal_touch/_nociception2.40009547
10MP0005167_abnormal_blood-brain_barrier2.37872183
11MP0008872_abnormal_physiological_respon2.18940208
12MP0001835_abnormal_antigen_presentation2.12770998
13MP0006072_abnormal_retinal_apoptosis2.00043977
14MP0001986_abnormal_taste_sensitivity1.84542667
15MP0003724_increased_susceptibility_to1.83838425
16MP0005253_abnormal_eye_physiology1.82653764
17MP0000372_irregular_coat_pigmentation1.80379340
18MP0003786_premature_aging1.75707562
19MP0005551_abnormal_eye_electrophysiolog1.73501399
20MP0006292_abnormal_olfactory_placode1.72701613
21MP0006276_abnormal_autonomic_nervous1.72052074
22MP0001984_abnormal_olfaction1.71042350
23MP0001501_abnormal_sleep_pattern1.66974990
24MP0008875_abnormal_xenobiotic_pharmacok1.65786911
25MP0004147_increased_porphyrin_level1.62963472
26MP0009697_abnormal_copulation1.57028471
27MP0005083_abnormal_biliary_tract1.56831802
28MP0003011_delayed_dark_adaptation1.55332734
29MP0002277_abnormal_respiratory_mucosa1.53555691
30MP0009745_abnormal_behavioral_response1.53071716
31MP0002234_abnormal_pharynx_morphology1.47699734
32MP0009046_muscle_twitch1.38791883
33MP0000013_abnormal_adipose_tissue1.35827418
34MP0005410_abnormal_fertilization1.34955345
35MP0002272_abnormal_nervous_system1.32119471
36MP0004084_abnormal_cardiac_muscle1.31750053
37MP0002876_abnormal_thyroid_physiology1.30665507
38MP0002148_abnormal_hypersensitivity_rea1.30651271
39MP0006035_abnormal_mitochondrial_morpho1.29317474
40MP0008775_abnormal_heart_ventricle1.28553908
41MP0006054_spinal_hemorrhage1.23795936
42MP0000427_abnormal_hair_cycle1.21342992
43MP0001661_extended_life_span1.19288805
44MP0002837_dystrophic_cardiac_calcinosis1.16957007
45MP0002909_abnormal_adrenal_gland1.16144574
46MP0002733_abnormal_thermal_nociception1.14381886
47MP0005387_immune_system_phenotype1.13342657
48MP0001790_abnormal_immune_system1.13342657
49MP0003806_abnormal_nucleotide_metabolis1.11018162
50MP0006082_CNS_inflammation1.10856271
51MP0005645_abnormal_hypothalamus_physiol1.06564133
52MP0005000_abnormal_immune_tolerance1.05435242
53MP0000383_abnormal_hair_follicle1.04989006
54MP0003186_abnormal_redox_activity1.04304116
55MP0009785_altered_susceptibility_to1.01940681
56MP0003137_abnormal_impulse_conducting1.01833263
57MP0009780_abnormal_chondrocyte_physiolo1.01652207
58MP0006036_abnormal_mitochondrial_physio1.01372511
59MP0002006_tumorigenesis0.99085282
60MP0002723_abnormal_immune_serum0.97398945
61MP0000230_abnormal_systemic_arterial0.96397848
62MP0001970_abnormal_pain_threshold0.95917604
63MP0004484_altered_response_of0.95727116
64MP0001800_abnormal_humoral_immune0.94490665
65MP0001905_abnormal_dopamine_level0.94466756
66MP0005646_abnormal_pituitary_gland0.92889774
67MP0004885_abnormal_endolymph0.92741305
68MP0004142_abnormal_muscle_tone0.90938634
69MP0000465_gastrointestinal_hemorrhage0.90397762
70MP0003195_calcinosis0.90043471
71MP0002166_altered_tumor_susceptibility0.89979667
72MP0008058_abnormal_DNA_repair0.89886025
73MP0002282_abnormal_trachea_morphology0.88546441
74MP0002067_abnormal_sensory_capabilities0.87247164
75MP0003646_muscle_fatigue0.86387559
76MP0005464_abnormal_platelet_physiology0.85119491
77MP0002572_abnormal_emotion/affect_behav0.84839419
78MP0001764_abnormal_homeostasis0.84797394
79MP0001485_abnormal_pinna_reflex0.84489191
80MP0001919_abnormal_reproductive_system0.84171591
81MP0003787_abnormal_imprinting0.84049220
82MP0002938_white_spotting0.84032590
83MP0001486_abnormal_startle_reflex0.82898879
84MP0003718_maternal_effect0.82027141
85MP0009333_abnormal_splenocyte_physiolog0.81915403
86MP0000358_abnormal_cell_content/0.80532955
87MP0010386_abnormal_urinary_bladder0.80407611
88MP0002163_abnormal_gland_morphology0.76476324
89MP0003567_abnormal_fetal_cardiomyocyte0.75846481
90MP0004215_abnormal_myocardial_fiber0.75467071
91MP0003763_abnormal_thymus_physiology0.75266838
92MP0002638_abnormal_pupillary_reflex0.72663658
93MP0002420_abnormal_adaptive_immunity0.71774510
94MP0004036_abnormal_muscle_relaxation0.70968824
95MP0002557_abnormal_social/conspecific_i0.70770714
96MP0001819_abnormal_immune_cell0.69553693
97MP0005332_abnormal_amino_acid0.68314073
98MP0000647_abnormal_sebaceous_gland0.66995123
99MP0001929_abnormal_gametogenesis0.66636665
100MP0005075_abnormal_melanosome_morpholog0.66275448

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)3.81200100
2Acute necrotizing encephalopathy (HP:0006965)3.58434992
3Nephronophthisis (HP:0000090)3.32931303
4Pancreatic cysts (HP:0001737)3.32700181
5Acute encephalopathy (HP:0006846)3.29209123
6Increased CSF lactate (HP:0002490)3.27883578
7Mitochondrial inheritance (HP:0001427)3.27443479
8Abnormality of the renal cortex (HP:0011035)3.26357599
9Stomatitis (HP:0010280)3.21782571
10Abnormality of midbrain morphology (HP:0002418)3.15305019
11Molar tooth sign on MRI (HP:0002419)3.15305019
12Abnormal mitochondria in muscle tissue (HP:0008316)3.09997025
13Renal cortical cysts (HP:0000803)3.06960508
14Progressive macrocephaly (HP:0004481)3.04243752
15Abolished electroretinogram (ERG) (HP:0000550)3.01504350
16IgG deficiency (HP:0004315)3.00569991
17True hermaphroditism (HP:0010459)2.95329242
18Hepatocellular necrosis (HP:0001404)2.93832556
19Hypothermia (HP:0002045)2.93542988
20Hepatic necrosis (HP:0002605)2.89753062
21Pancreatic fibrosis (HP:0100732)2.76270041
22Optic disc pallor (HP:0000543)2.73224902
23Methylmalonic acidemia (HP:0002912)2.70395001
24Medial flaring of the eyebrow (HP:0010747)2.68094837
25Abnormality of the renal medulla (HP:0100957)2.67390915
26B lymphocytopenia (HP:0010976)2.63381132
27Elevated erythrocyte sedimentation rate (HP:0003565)2.58716923
28Abnormality of B cell number (HP:0010975)2.55960328
29Progressive inability to walk (HP:0002505)2.52107356
30Bile duct proliferation (HP:0001408)2.51379495
31Abnormal biliary tract physiology (HP:0012439)2.51379495
32Increased serum lactate (HP:0002151)2.48234058
33Thyroiditis (HP:0100646)2.48118544
34Attenuation of retinal blood vessels (HP:0007843)2.47807076
35Cerebral edema (HP:0002181)2.47492269
36Abnormality of alanine metabolism (HP:0010916)2.45682484
37Hyperalaninemia (HP:0003348)2.45682484
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.45682484
39Hypoproteinemia (HP:0003075)2.45573448
40Severe combined immunodeficiency (HP:0004430)2.44606644
41Panhypogammaglobulinemia (HP:0003139)2.43919323
42Congenital, generalized hypertrichosis (HP:0004540)2.40095605
43Decreased electroretinogram (ERG) amplitude (HP:0000654)2.38787297
44Inability to walk (HP:0002540)2.33212606
45Lactic acidosis (HP:0003128)2.30381331
46Methylmalonic aciduria (HP:0012120)2.27501314
47Congenital stationary night blindness (HP:0007642)2.25256471
48Aplasia/hypoplasia of the uterus (HP:0008684)2.21178738
49Abnormality of T cells (HP:0002843)2.18423009
50Abnormality of T cell number (HP:0011839)2.11347775
51Testicular atrophy (HP:0000029)2.08890446
52Type I transferrin isoform profile (HP:0003642)2.08831318
53Increased hepatocellular lipid droplets (HP:0006565)2.08207815
54Abnormality of T cell physiology (HP:0011840)2.05071309
55Type II lissencephaly (HP:0007260)2.02818180
56Increased IgM level (HP:0003496)2.02335847
57T lymphocytopenia (HP:0005403)2.02326028
58Retinal dysplasia (HP:0007973)2.02109994
59Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.00808289
60Absent rod-and cone-mediated responses on ERG (HP:0007688)1.98732819
61Decreased activity of mitochondrial respiratory chain (HP:0008972)1.98007168
62Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.98007168
63Tubular atrophy (HP:0000092)1.97647921
64Encephalitis (HP:0002383)1.96985453
65Lethargy (HP:0001254)1.95746075
66Lissencephaly (HP:0001339)1.93006611
67Dyschromatopsia (HP:0007641)1.91379181
68Constricted visual fields (HP:0001133)1.90288446
69Abnormal delayed hypersensitivity skin test (HP:0002963)1.88727457
70Abnormality of the fovea (HP:0000493)1.88315917
71Poor speech (HP:0002465)1.88145033
72Recurrent cutaneous fungal infections (HP:0011370)1.87677094
73Chronic mucocutaneous candidiasis (HP:0002728)1.87677094
74Abnormality of the metopic suture (HP:0005556)1.87047960
75Lipid accumulation in hepatocytes (HP:0006561)1.86720020
76Abnormality of the pons (HP:0007361)1.86609504
77CNS hypomyelination (HP:0003429)1.86060788
78Emotional lability (HP:0000712)1.84481457
79Cerebral hypomyelination (HP:0006808)1.83984247
80Leukodystrophy (HP:0002415)1.83204754
81Abnormal protein N-linked glycosylation (HP:0012347)1.82306978
82Abnormal protein glycosylation (HP:0012346)1.82306978
83Abnormal glycosylation (HP:0012345)1.82306978
84Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82306978
85Neonatal respiratory distress (HP:0002643)1.81851355
86Abnormality of eosinophils (HP:0001879)1.81754104
87Disproportionate short-trunk short stature (HP:0003521)1.80520640
88Pendular nystagmus (HP:0012043)1.79747689
89Hypomagnesemia (HP:0002917)1.78938149
90Optic nerve hypoplasia (HP:0000609)1.77629770
91Chronic hepatic failure (HP:0100626)1.76856585
92Congenital primary aphakia (HP:0007707)1.76526697
93Prominent metopic ridge (HP:0005487)1.76500089
94Polydipsia (HP:0001959)1.76361337
95Abnormal drinking behavior (HP:0030082)1.76361337
96Gait imbalance (HP:0002141)1.76076330
97Dicarboxylic aciduria (HP:0003215)1.75648563
98Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75648563
99Neutropenia (HP:0001875)1.73846423
100Pachygyria (HP:0001302)1.73504370

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.77415307
2TRIM284.31665469
3BCR3.42166114
4TXK2.81256732
5MST42.54615623
6BCKDK2.45533136
7ZAK2.27438531
8VRK22.25940391
9TIE12.19945071
10BMPR1B2.19689554
11SIK32.14701708
12TLK12.13341113
13EIF2AK32.00296112
14ADRBK21.91985698
15GRK11.90114604
16SRPK11.77343973
17VRK11.76896961
18PINK11.76783508
19TAOK31.73422629
20LIMK11.65289253
21FRK1.65097279
22CSNK1G31.58762529
23TESK21.57614092
24MAP3K121.50786682
25KDR1.45274778
26CSNK1A1L1.44376926
27MAP3K41.43498879
28CSNK1G21.42326784
29TESK11.41652639
30CSNK1G11.40754435
31NUAK11.28901333
32MAP2K71.22233374
33DYRK21.19027651
34MAP4K11.17706768
35FES1.06649997
36MAPKAPK31.01441664
37OXSR11.00633946
38MAPK130.99989240
39PLK30.97972426
40TSSK60.96157643
41INSRR0.96030936
42MYLK0.91281926
43PLK20.90593778
44TGFBR10.89778857
45GRK50.88542928
46DAPK10.88061856
47ERBB30.83580490
48PAK30.83337492
49WNK30.83025251
50TEC0.81629003
51CDK190.79191254
52EIF2AK10.76396746
53CSF1R0.75577345
54MINK10.74342134
55PTK2B0.74198158
56CLK10.73303513
57RPS6KA50.71340729
58TAF10.69780476
59RPS6KA40.68941014
60CAMKK20.68758838
61CDK80.67428875
62CASK0.66845366
63MAPKAPK50.57776927
64PRKCQ0.56814559
65PDK20.56250944
66NEK10.56161590
67PRKCE0.54088607
68MARK10.53915548
69STK390.48243882
70KIT0.46169741
71STK160.45922772
72SCYL20.45779027
73MAP2K60.45682560
74FER0.45439677
75PHKG10.44722539
76PHKG20.44722539
77SYK0.44518675
78IGF1R0.44017571
79CAMK2A0.43658215
80CSNK1A10.42743231
81EIF2AK20.42661906
82KSR10.41445060
83CDK180.39707936
84ADRBK10.38170441
85CDK140.37674026
86IKBKB0.37472979
87DAPK20.36808251
88TNIK0.35223425
89LYN0.34725916
90PRKCG0.34367383
91STK38L0.33635874
92PAK60.33003521
93ABL10.30012202
94EGFR0.29884046
95LCK0.29643544
96DAPK30.29537532
97CAMK2D0.27973286
98WNK40.27380707
99EPHA30.27233873
100PRKACA0.26692875

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.88869855
2Proteasome_Homo sapiens_hsa030503.78636256
3Oxidative phosphorylation_Homo sapiens_hsa001903.28258333
4Parkinsons disease_Homo sapiens_hsa050122.45295033
5Phototransduction_Homo sapiens_hsa047442.24242490
6Basal transcription factors_Homo sapiens_hsa030222.18480707
7Primary immunodeficiency_Homo sapiens_hsa053402.18343130
8Nitrogen metabolism_Homo sapiens_hsa009102.03088183
9RNA polymerase_Homo sapiens_hsa030201.89535870
10Graft-versus-host disease_Homo sapiens_hsa053321.88679026
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.86124941
12Collecting duct acid secretion_Homo sapiens_hsa049661.81148403
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72591621
14Allograft rejection_Homo sapiens_hsa053301.63743386
15Propanoate metabolism_Homo sapiens_hsa006401.62910243
16Regulation of autophagy_Homo sapiens_hsa041401.59390667
17Asthma_Homo sapiens_hsa053101.59201463
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.56666830
19Huntingtons disease_Homo sapiens_hsa050161.55083540
20Alzheimers disease_Homo sapiens_hsa050101.53284113
21RNA degradation_Homo sapiens_hsa030181.49686659
22Antigen processing and presentation_Homo sapiens_hsa046121.48681773
23Autoimmune thyroid disease_Homo sapiens_hsa053201.47510250
24Type I diabetes mellitus_Homo sapiens_hsa049401.46383935
25Rheumatoid arthritis_Homo sapiens_hsa053231.40087078
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39076353
27Fatty acid elongation_Homo sapiens_hsa000621.36004785
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.34430169
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27126687
30Sulfur metabolism_Homo sapiens_hsa009201.26904552
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24393195
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23310684
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22117170
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21412511
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16442495
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13681819
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13298603
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12026657
39Pyrimidine metabolism_Homo sapiens_hsa002401.09560901
40Linoleic acid metabolism_Homo sapiens_hsa005911.09338435
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.08424242
42Peroxisome_Homo sapiens_hsa041461.06284621
43Nicotine addiction_Homo sapiens_hsa050331.05119783
44Homologous recombination_Homo sapiens_hsa034400.98640762
45Tryptophan metabolism_Homo sapiens_hsa003800.98610622
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98342100
47Hematopoietic cell lineage_Homo sapiens_hsa046400.97149085
48Cardiac muscle contraction_Homo sapiens_hsa042600.96872574
49Caffeine metabolism_Homo sapiens_hsa002320.95724504
50Nucleotide excision repair_Homo sapiens_hsa034200.95440863
51Purine metabolism_Homo sapiens_hsa002300.94407476
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86431715
53Ether lipid metabolism_Homo sapiens_hsa005650.86420455
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83890640
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83738337
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83706224
57Butanoate metabolism_Homo sapiens_hsa006500.79396046
58Fanconi anemia pathway_Homo sapiens_hsa034600.77863053
59One carbon pool by folate_Homo sapiens_hsa006700.77849617
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.75211920
61Systemic lupus erythematosus_Homo sapiens_hsa053220.74620498
62Vibrio cholerae infection_Homo sapiens_hsa051100.73348344
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72891866
64Non-homologous end-joining_Homo sapiens_hsa034500.72332711
65Mismatch repair_Homo sapiens_hsa034300.71670427
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70757979
67Morphine addiction_Homo sapiens_hsa050320.69517268
68RNA transport_Homo sapiens_hsa030130.69402050
69Retinol metabolism_Homo sapiens_hsa008300.69202641
70GABAergic synapse_Homo sapiens_hsa047270.67714916
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67466457
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66958307
73Taste transduction_Homo sapiens_hsa047420.65828759
74Metabolic pathways_Homo sapiens_hsa011000.65789245
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65379348
76Fatty acid metabolism_Homo sapiens_hsa012120.64568931
77Olfactory transduction_Homo sapiens_hsa047400.63729340
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61769692
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59495929
80Spliceosome_Homo sapiens_hsa030400.59382399
81Chemical carcinogenesis_Homo sapiens_hsa052040.57648012
82Selenocompound metabolism_Homo sapiens_hsa004500.57158308
83Glutathione metabolism_Homo sapiens_hsa004800.55465116
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54885376
85Fatty acid degradation_Homo sapiens_hsa000710.53383885
86Circadian rhythm_Homo sapiens_hsa047100.52395712
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49732334
88Shigellosis_Homo sapiens_hsa051310.49213569
89Pyruvate metabolism_Homo sapiens_hsa006200.47801145
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47478954
91Synaptic vesicle cycle_Homo sapiens_hsa047210.46928668
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46450140
93T cell receptor signaling pathway_Homo sapiens_hsa046600.46378156
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46226419
95Circadian entrainment_Homo sapiens_hsa047130.45211655
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44787684
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43843618
98Steroid biosynthesis_Homo sapiens_hsa001000.43697993
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42734190
100Serotonergic synapse_Homo sapiens_hsa047260.39839402

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