YWHAB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)6.02050764
2synaptic vesicle maturation (GO:0016188)5.85604293
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.71395307
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.58527234
5vocalization behavior (GO:0071625)5.23513893
6regulation of synaptic vesicle exocytosis (GO:2000300)5.17943714
7glutamate secretion (GO:0014047)5.09334849
8protein maturation by protein folding (GO:0022417)5.07427411
9protein localization to synapse (GO:0035418)5.05585779
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.02325003
11locomotory exploration behavior (GO:0035641)4.93430501
12layer formation in cerebral cortex (GO:0021819)4.85856689
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.85317241
14positive regulation of synapse maturation (GO:0090129)4.64333616
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.54596800
16regulation of glutamate receptor signaling pathway (GO:1900449)4.52563390
17neuron cell-cell adhesion (GO:0007158)4.51892687
18regulation of synaptic vesicle transport (GO:1902803)4.50933413
19exploration behavior (GO:0035640)4.45045505
20cellular potassium ion homeostasis (GO:0030007)4.37519152
21establishment of integrated proviral latency (GO:0075713)4.33249179
22neurotransmitter secretion (GO:0007269)4.30733602
23regulation of synapse structural plasticity (GO:0051823)4.18814810
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.16328144
25proteasome assembly (GO:0043248)4.15975901
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.04509477
27ionotropic glutamate receptor signaling pathway (GO:0035235)4.01179173
28proline transport (GO:0015824)3.97997672
29regulation of neuronal synaptic plasticity (GO:0048168)3.97062075
30synaptic vesicle endocytosis (GO:0048488)3.93785106
31glutamate receptor signaling pathway (GO:0007215)3.91295630
32gamma-aminobutyric acid signaling pathway (GO:0007214)3.80134762
33negative regulation of microtubule polymerization (GO:0031115)3.79124265
34neuron recognition (GO:0008038)3.78892786
35activation of protein kinase A activity (GO:0034199)3.76098205
36chaperone-mediated protein transport (GO:0072321)3.75716835
37positive regulation of dendritic spine morphogenesis (GO:0061003)3.72266843
38dendritic spine morphogenesis (GO:0060997)3.72210601
39neuronal action potential propagation (GO:0019227)3.70951600
40mating behavior (GO:0007617)3.69341214
41sodium ion export (GO:0071436)3.69222585
42neuron-neuron synaptic transmission (GO:0007270)3.66183704
43synaptic transmission, glutamatergic (GO:0035249)3.58504138
44innervation (GO:0060384)3.57884901
45* positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling3.54695105
46* regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 3.54695105
47negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.53870781
48positive regulation of synaptic transmission, GABAergic (GO:0032230)3.53768184
49neurotransmitter transport (GO:0006836)3.50317288
50regulation of vesicle fusion (GO:0031338)3.50308704
51long-term memory (GO:0007616)3.49141323
52regulation of dendritic spine morphogenesis (GO:0061001)3.47623844
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.46831437
54anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.45281154
55de novo protein folding (GO:0006458)3.45264053
56regulation of excitatory postsynaptic membrane potential (GO:0060079)3.43597690
57mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.43354847
58response to pheromone (GO:0019236)3.42203543
59neurotransmitter-gated ion channel clustering (GO:0072578)3.41037579
60regulation of synapse maturation (GO:0090128)3.39708090
61positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.39602785
62establishment of viral latency (GO:0019043)3.37962904
63axonal fasciculation (GO:0007413)3.36922285
64regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.36792879
65regulation of postsynaptic membrane potential (GO:0060078)3.35786536
66positive regulation of membrane potential (GO:0045838)3.35696976
67positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.32839231
68positive regulation of vesicle fusion (GO:0031340)3.32657823
69regulation of neurotransmitter secretion (GO:0046928)3.28603758
70cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.28540416
71negative regulation of ligase activity (GO:0051352)3.27916697
72negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.27916697
73regulation of synaptic plasticity (GO:0048167)3.27412539
74regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.26389428
75regulation of cellular amino acid metabolic process (GO:0006521)3.25626857
76long-term synaptic potentiation (GO:0060291)3.24392434
77* positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.24379672
78negative regulation of synaptic transmission, GABAergic (GO:0032229)3.22870347
79G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.21788300
80regulation of synaptic transmission, glutamatergic (GO:0051966)3.21547179
81synaptic vesicle transport (GO:0048489)3.21402518
82establishment of synaptic vesicle localization (GO:0097480)3.21402518
83positive regulation of actin filament depolymerization (GO:0030836)3.20909084
84regulation of neurotransmitter levels (GO:0001505)3.20890106
85vesicle transport along microtubule (GO:0047496)3.19665646
86positive regulation of dendritic spine development (GO:0060999)3.19244864
87positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.19019018
88cell communication by electrical coupling (GO:0010644)3.18009666
89synapse assembly (GO:0007416)3.17698825
90axon cargo transport (GO:0008088)3.17301392
91behavioral fear response (GO:0001662)3.17238006
92behavioral defense response (GO:0002209)3.17238006
93dendrite morphogenesis (GO:0048813)3.16100143
94de novo posttranslational protein folding (GO:0051084)3.14006313
952-deoxyribonucleotide biosynthetic process (GO:0009265)3.13232023
96deoxyribose phosphate biosynthetic process (GO:0046385)3.13232023
97cell migration in hindbrain (GO:0021535)3.09726219
98G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.09202163
99organelle transport along microtubule (GO:0072384)3.08525351
100nucleobase-containing small molecule interconversion (GO:0015949)3.06658858
101response to histamine (GO:0034776)3.05742300
102deoxyribonucleotide biosynthetic process (GO:0009263)3.05316306
103positive regulation of neurotransmitter secretion (GO:0001956)3.03631072
104membrane hyperpolarization (GO:0060081)3.03467290
105regulation of neurotransmitter transport (GO:0051588)3.02324690
106regulation of translational termination (GO:0006449)3.00944400
107regulation of mitotic spindle organization (GO:0060236)2.99209588
108neuromuscular process controlling balance (GO:0050885)2.99017790
109transmission of nerve impulse (GO:0019226)2.98648279
110regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.98294660
111postsynaptic membrane organization (GO:0001941)2.96920169
112regulation of cAMP-dependent protein kinase activity (GO:2000479)2.96228443
113social behavior (GO:0035176)2.95592418
114intraspecies interaction between organisms (GO:0051703)2.95592418
115localization within membrane (GO:0051668)2.95425340
116positive regulation of neurotransmitter transport (GO:0051590)2.94998075
117fear response (GO:0042596)2.92946038
118establishment of vesicle localization (GO:0051650)2.92822396
119gamma-aminobutyric acid transport (GO:0015812)2.92502612
120regulation of dendritic spine development (GO:0060998)2.92240908
121learning (GO:0007612)2.92170660
122membrane depolarization (GO:0051899)2.90384906
123positive regulation of synaptic transmission (GO:0050806)2.88938597
124establishment of protein localization to mitochondrial membrane (GO:0090151)2.87685339
125substantia nigra development (GO:0021762)2.87326771
126cerebellar Purkinje cell differentiation (GO:0021702)2.87285503
127synaptic transmission (GO:0007268)2.87172308
128regulation of synaptic transmission (GO:0050804)2.86677361
129potassium ion homeostasis (GO:0055075)2.85777864
130clathrin coat assembly (GO:0048268)2.85580332
131long term synaptic depression (GO:0060292)2.85016235
132regulation of mitochondrial translation (GO:0070129)2.84778953
133positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.83096028
134ribosome assembly (GO:0042255)2.81789145
135DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.81445504
136antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.81434650
137regulation of cellular amine metabolic process (GO:0033238)2.81228731
138intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.78982986
139signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.78982986
140protein localization to endosome (GO:0036010)2.77807413
141adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.76000377
142signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.71371602
143signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.71371602
144signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.71371602
145signal transduction involved in DNA damage checkpoint (GO:0072422)2.71275595
146signal transduction involved in DNA integrity checkpoint (GO:0072401)2.71275595
147mitotic metaphase plate congression (GO:0007080)2.70722933
148* regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.70269815
149substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.68304619
150substrate-independent telencephalic tangential migration (GO:0021826)2.68304619
151regulation of ubiquitin-protein transferase activity (GO:0051438)2.67912820
152regulation of defense response to virus by virus (GO:0050690)2.66930256
153positive regulation of ligase activity (GO:0051351)2.66412770
154signal transduction involved in cell cycle checkpoint (GO:0072395)2.65460572
155amino acid import (GO:0043090)2.65403357
156antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.65228301
157ATP synthesis coupled proton transport (GO:0015986)2.61855523
158energy coupled proton transport, down electrochemical gradient (GO:0015985)2.61855523
159RNA-dependent DNA replication (GO:0006278)2.60890772
160protein targeting to mitochondrion (GO:0006626)2.58247068
161regulation of spindle organization (GO:0090224)2.55892033
162regulation of ligase activity (GO:0051340)2.54433751
163actin filament depolymerization (GO:0030042)2.51959672
164respiratory electron transport chain (GO:0022904)2.51704238
165protein localization to mitochondrion (GO:0070585)2.49384445
166regulation of microtubule polymerization (GO:0031113)2.46372221
167neurofilament cytoskeleton organization (GO:0060052)2.45316568
168establishment of chromosome localization (GO:0051303)2.41943817
169transferrin transport (GO:0033572)2.41474856
170positive regulation of lamellipodium assembly (GO:0010592)2.41081296

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.96347233
2E2F7_22180533_ChIP-Seq_HELA_Human4.55465326
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.06220364
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.50820496
5GBX2_23144817_ChIP-Seq_PC3_Human3.46545093
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.44292799
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.42921953
8JARID2_20064375_ChIP-Seq_MESCs_Mouse3.38730270
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.30079421
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.23311009
11EZH2_18974828_ChIP-Seq_MESCs_Mouse3.01487218
12RNF2_18974828_ChIP-Seq_MESCs_Mouse3.01487218
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.92766925
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.84386782
15REST_21632747_ChIP-Seq_MESCs_Mouse2.84088135
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.83802522
17THAP11_20581084_ChIP-Seq_MESCs_Mouse2.83420325
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.80822649
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.73185596
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.71195772
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.70169751
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.69233145
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.66709022
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.66456647
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.58315032
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.55476480
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52378663
28MYC_18358816_ChIP-ChIP_MESCs_Mouse2.50897905
29* AR_21909140_ChIP-Seq_LNCAP_Human2.47674733
30EED_16625203_ChIP-ChIP_MESCs_Mouse2.41170340
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.40197376
32MYC_19030024_ChIP-ChIP_MESCs_Mouse2.37993621
33SUZ12_27294783_Chip-Seq_ESCs_Mouse2.37634504
34REST_18959480_ChIP-ChIP_MESCs_Mouse2.36544022
35EZH2_27294783_Chip-Seq_ESCs_Mouse2.35649386
36DROSHA_22980978_ChIP-Seq_HELA_Human2.33242719
37NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30788429
38GABP_17652178_ChIP-ChIP_JURKAT_Human2.29240381
39RNF2_27304074_Chip-Seq_ESCs_Mouse2.29218148
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.23709520
41* ZFX_18555785_ChIP-Seq_MESCs_Mouse2.18783684
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.16497820
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15546343
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.13754064
45AR_21572438_ChIP-Seq_LNCaP_Human2.13675639
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09672024
47* KLF4_18555785_ChIP-Seq_MESCs_Mouse2.09501468
48ETS1_20019798_ChIP-Seq_JURKAT_Human2.08028947
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.04981845
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02608769
51MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02088785
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.94522579
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92417264
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92044302
55TAF15_26573619_Chip-Seq_HEK293_Human1.90920505
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.90659857
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85318903
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84862449
59ZNF274_21170338_ChIP-Seq_K562_Hela1.83385772
60* GABP_19822575_ChIP-Seq_HepG2_Human1.81979940
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.79279457
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79074978
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.77565140
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76909668
65DCP1A_22483619_ChIP-Seq_HELA_Human1.76734124
66CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.75835399
67SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.75135174
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74351562
69SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.71825035
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.68268230
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66734485
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.64890890
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.63524751
74XRN2_22483619_ChIP-Seq_HELA_Human1.62069360
75* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.62033557
76SMAD4_21799915_ChIP-Seq_A2780_Human1.61814769
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.58900001
78ZNF263_19887448_ChIP-Seq_K562_Human1.57541248
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.54509475
80CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.53083983
81ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51125311
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50778591
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.48912586
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48858122
85IGF1R_20145208_ChIP-Seq_DFB_Human1.48741577
86RING1B_27294783_Chip-Seq_ESCs_Mouse1.47620949
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.45872384
88ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44383746
89* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40978286
90* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.40865898
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.40658855
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40571394
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.40460215
94OCT4_18692474_ChIP-Seq_MEFs_Mouse1.40111720
95* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39435510
96P300_19829295_ChIP-Seq_ESCs_Human1.37878828
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37305003
98AR_25329375_ChIP-Seq_VCAP_Human1.36718190
99* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.35182660
100SMAD_19615063_ChIP-ChIP_OVARY_Human1.34137163
101SOX2_21211035_ChIP-Seq_LN229_Gbm1.32162427
102RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31337543
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29409080
104KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29102570
105BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29011662
106ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28753285
107TTF2_22483619_ChIP-Seq_HELA_Human1.26991823
108PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.26792283
109DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26453922
110YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25184673
111E2F1_21310950_ChIP-Seq_MCF-7_Human1.25128786
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24761623
113NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22967809
114GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.22896911
115ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22418343
116* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.21338549
117TFEB_21752829_ChIP-Seq_HELA_Human1.21188291
118SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21158187
119RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20140497
120RING1B_27294783_Chip-Seq_NPCs_Mouse1.19834366
121SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.19508691
122OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19491527
123* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19321925
124* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19221953
125TBX5_21415370_ChIP-Seq_HL-1_Mouse1.19180178
126P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19158534
127SMAD3_21741376_ChIP-Seq_EPCs_Human1.18684246
128HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18682247
129CBX2_27304074_Chip-Seq_ESCs_Mouse1.18171135
130SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18153940
131TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17318293
132AR_19668381_ChIP-Seq_PC3_Human1.17068662
133FOXP3_21729870_ChIP-Seq_TREG_Human1.16425092
134WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16210044
135* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.15975984
136THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15246839
137CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14806647
138NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13520340
139* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11746790
140KDM2B_26808549_Chip-Seq_K562_Human1.11271906
141YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09930452
142RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09328315
143REST_19997604_ChIP-ChIP_NEURONS_Mouse1.09187595
144JUN_21703547_ChIP-Seq_K562_Human1.08949492
145STAT3_23295773_ChIP-Seq_U87_Human1.08654019
146RNF2_27304074_Chip-Seq_NSC_Mouse1.07910990
147TET1_21451524_ChIP-Seq_MESCs_Mouse1.07138550
148TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05987138
149E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05637232
150SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05637068
151MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04775956
152SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03324566
153PIAS1_25552417_ChIP-Seq_VCAP_Human1.02520376
154ELK1_19687146_ChIP-ChIP_HELA_Human1.01034661
155FUS_26573619_Chip-Seq_HEK293_Human1.00578504
156PRDM14_20953172_ChIP-Seq_ESCs_Human1.00513935
157TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00171507
158TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99208804
159EOMES_21245162_ChIP-Seq_HESCs_Human0.98838364
160CLOCK_20551151_ChIP-Seq_293T_Human0.98112560
161TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.97459257
162KDM5A_27292631_Chip-Seq_BREAST_Human0.97154336
163* ELF5_23300383_ChIP-Seq_T47D_Human0.96688819
164NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.96491526
165SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96138919
166MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96064943
167UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95552212
168SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94882044
169MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92686226
170* RUNX2_22187159_ChIP-Seq_PCA_Human0.92312763
171SMAD3_21741376_ChIP-Seq_ESCs_Human0.91893775
172TET1_21490601_ChIP-Seq_MESCs_Mouse0.91151831
173RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90814654
174ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90760062
175POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90693293
176SMAD4_21741376_ChIP-Seq_HESCs_Human0.90297843
177GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89360114
178TP53_20018659_ChIP-ChIP_R1E_Mouse0.89277164
179GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88955437
180TCF4_23295773_ChIP-Seq_U87_Human0.87951437
181TP53_16413492_ChIP-PET_HCT116_Human0.84959325
182* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84246683
183OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83754773
184CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83279904
185ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83084799
186AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82249614
187* BCAT_22108803_ChIP-Seq_LS180_Human0.81678090
188ARNT_22903824_ChIP-Seq_MCF-7_Human0.81531307
189IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80629083
190CBP_20019798_ChIP-Seq_JUKART_Human0.80629083

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.05959499
2MP0003880_abnormal_central_pattern4.79386098
3MP0003635_abnormal_synaptic_transmissio4.06772931
4MP0004270_analgesia3.45142388
5MP0001968_abnormal_touch/_nociception3.28299402
6MP0002063_abnormal_learning/memory/cond3.22483083
7MP0002877_abnormal_melanocyte_morpholog3.11940353
8MP0009745_abnormal_behavioral_response3.09347550
9MP0002064_seizures2.91176799
10MP0009046_muscle_twitch2.78538136
11MP0002734_abnormal_mechanical_nocicepti2.67386253
12MP0006276_abnormal_autonomic_nervous2.59371339
13MP0002735_abnormal_chemical_nociception2.59293719
14MP0002572_abnormal_emotion/affect_behav2.59102896
15MP0002736_abnormal_nociception_after2.54119115
16MP0005423_abnormal_somatic_nervous2.41142327
17MP0002272_abnormal_nervous_system2.40446487
18MP0001501_abnormal_sleep_pattern2.34608487
19MP0003693_abnormal_embryo_hatching2.32415887
20MP0004957_abnormal_blastocyst_morpholog2.27505660
21MP0002733_abnormal_thermal_nociception2.24270220
22MP0001486_abnormal_startle_reflex2.19655683
23MP0002796_impaired_skin_barrier2.17791639
24MP0002184_abnormal_innervation2.13183876
25MP0001970_abnormal_pain_threshold2.05248618
26MP0008877_abnormal_DNA_methylation2.03741032
27MP0003329_amyloid_beta_deposits1.99986691
28MP0004858_abnormal_nervous_system1.99477393
29MP0001440_abnormal_grooming_behavior1.99289934
30MP0002067_abnormal_sensory_capabilities1.98018684
31MP0002909_abnormal_adrenal_gland1.96328049
32MP0003806_abnormal_nucleotide_metabolis1.95728464
33MP0008260_abnormal_autophagy1.95363572
34MP0003122_maternal_imprinting1.93225101
35MP0004811_abnormal_neuron_physiology1.89477291
36MP0000778_abnormal_nervous_system1.82669898
37MP0005386_behavior/neurological_phenoty1.75246430
38MP0004924_abnormal_behavior1.75246430
39MP0001984_abnormal_olfaction1.73919392
40MP0002822_catalepsy1.72910878
41MP0002557_abnormal_social/conspecific_i1.67513986
42MP0009780_abnormal_chondrocyte_physiolo1.64730080
43MP0008569_lethality_at_weaning1.63033773
44MP0003111_abnormal_nucleus_morphology1.61116761
45MP0000955_abnormal_spinal_cord1.54274215
46MP0003191_abnormal_cellular_cholesterol1.48689476
47MP0000013_abnormal_adipose_tissue1.48166179
48MP0001188_hyperpigmentation1.47621928
49MP0010094_abnormal_chromosome_stability1.46360830
50MP0002882_abnormal_neuron_morphology1.43546764
51MP0003879_abnormal_hair_cell1.41553779
52MP0005501_abnormal_skin_physiology1.40041033
53MP0000015_abnormal_ear_pigmentation1.39970447
54MP0001348_abnormal_lacrimal_gland1.38846740
55MP0008932_abnormal_embryonic_tissue1.37606344
56MP0003077_abnormal_cell_cycle1.37568232
57MP0010386_abnormal_urinary_bladder1.35811448
58MP0002066_abnormal_motor_capabilities/c1.33083513
59MP0001529_abnormal_vocalization1.32829540
60MP0001905_abnormal_dopamine_level1.27409301
61MP0006035_abnormal_mitochondrial_morpho1.23716465
62MP0001502_abnormal_circadian_rhythm1.19824743
63MP0008007_abnormal_cellular_replicative1.18742335
64MP0005645_abnormal_hypothalamus_physiol1.17647187
65MP0005551_abnormal_eye_electrophysiolog1.17016401
66MP0000920_abnormal_myelination1.16055047
67MP0000350_abnormal_cell_proliferation1.14747436
68MP0001730_embryonic_growth_arrest1.14324441
69MP0004233_abnormal_muscle_weight1.14184910
70MP0010352_gastrointestinal_tract_polyps1.13105769
71MP0003186_abnormal_redox_activity1.12027240
72MP0005408_hypopigmentation1.11945848
73MP0003633_abnormal_nervous_system1.11515848
74MP0006036_abnormal_mitochondrial_physio1.10047668
75MP0000751_myopathy1.09995532
76MP0002090_abnormal_vision1.09885120
77MP0002152_abnormal_brain_morphology1.09190144
78MP0001853_heart_inflammation1.08992840
79MP0003787_abnormal_imprinting1.05772110
80MP0003566_abnormal_cell_adhesion0.99832996
81MP0008058_abnormal_DNA_repair0.96851938
82MP0004142_abnormal_muscle_tone0.95859778
83MP0005623_abnormal_meninges_morphology0.95560749
84MP0004885_abnormal_endolymph0.94917523
85MP0009672_abnormal_birth_weight0.94300821
86MP0000358_abnormal_cell_content/0.92979848
87MP0000569_abnormal_digit_pigmentation0.91091132
88MP0002638_abnormal_pupillary_reflex0.90499128
89MP0003123_paternal_imprinting0.90090906
90MP0003631_nervous_system_phenotype0.89411039
91MP0004130_abnormal_muscle_cell0.88688368
92MP0008057_abnormal_DNA_replication0.88580871
93MP0000490_abnormal_crypts_of0.87464541
94MP0005384_cellular_phenotype0.87463623
95MP0002069_abnormal_eating/drinking_beha0.87235937
96MP0002837_dystrophic_cardiac_calcinosis0.86685088
97MP0005187_abnormal_penis_morphology0.86064469
98MP0010234_abnormal_vibrissa_follicle0.86027364
99MP0005535_abnormal_body_temperature0.85598593
100MP0000604_amyloidosis0.84823045
101MP0002229_neurodegeneration0.84452268
102MP0003315_abnormal_perineum_morphology0.83652849
103MP0003866_abnormal_defecation0.82737977
104MP0008872_abnormal_physiological_respon0.82731426
105MP0008961_abnormal_basal_metabolism0.82176410
106MP0002752_abnormal_somatic_nervous0.81860841
107MP0002080_prenatal_lethality0.81793128
108MP0003890_abnormal_embryonic-extraembry0.81322041
109MP0005646_abnormal_pituitary_gland0.81186559
110MP0004215_abnormal_myocardial_fiber0.80800428
111MP0001697_abnormal_embryo_size0.78988821
112MP0001177_atelectasis0.78037040
113MP0005394_taste/olfaction_phenotype0.76706618
114MP0005499_abnormal_olfactory_system0.76706618
115MP0000631_abnormal_neuroendocrine_gland0.76623871
116MP0001881_abnormal_mammary_gland0.76397278
117MP0004085_abnormal_heartbeat0.76340313
118MP0005075_abnormal_melanosome_morpholog0.76309889
119MP0004145_abnormal_muscle_electrophysio0.76308885
120MP0005621_abnormal_cell_physiology0.75776643
121MP0003634_abnormal_glial_cell0.75418564
122MP0008874_decreased_physiological_sensi0.75368911
123MP0009379_abnormal_foot_pigmentation0.75328944
124MP0004742_abnormal_vestibular_system0.74306323
125MP0003183_abnormal_peptide_metabolism0.71626124
126MP0004484_altered_response_of0.69798165
127MP0000627_abnormal_mammary_gland0.69397813
128MP0003121_genomic_imprinting0.69294863
129MP0001664_abnormal_digestion0.65100861
130MP0000858_altered_metastatic_potential0.64738679
131MP0002876_abnormal_thyroid_physiology0.64695895
132MP0003861_abnormal_nervous_system0.63210537
133MP0000003_abnormal_adipose_tissue0.63208555
134MP0000579_abnormal_nail_morphology0.61729345
135MP0004264_abnormal_extraembryonic_tissu0.61618828
136MP0001346_abnormal_lacrimal_gland0.61114986
137MP0006072_abnormal_retinal_apoptosis0.61077504
138MP0003690_abnormal_glial_cell0.60804784
139MP0004782_abnormal_surfactant_physiolog0.60754085
140MP0001299_abnormal_eye_distance/0.60097791
141MP0001963_abnormal_hearing_physiology0.59470370
142MP0000534_abnormal_ureter_morphology0.59147509
143MP0005595_abnormal_vascular_smooth0.59081309
144MP0002751_abnormal_autonomic_nervous0.58179624
145MP0001943_abnormal_respiration0.57583399
146MP0005409_darkened_coat_color0.56571741
147MP0002234_abnormal_pharynx_morphology0.54246953
148MP0003075_altered_response_to0.53569214

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.18591474
2Myokymia (HP:0002411)5.67704118
3Visual hallucinations (HP:0002367)5.38446277
4Focal seizures (HP:0007359)5.18340051
5Epileptic encephalopathy (HP:0200134)4.43170940
6Absence seizures (HP:0002121)4.27738590
7Atonic seizures (HP:0010819)4.21345488
8Cerebral hypomyelination (HP:0006808)4.14899692
9Progressive cerebellar ataxia (HP:0002073)3.99484899
10Mutism (HP:0002300)3.88122582
11Supranuclear gaze palsy (HP:0000605)3.75186335
12Dialeptic seizures (HP:0011146)3.70146699
13Febrile seizures (HP:0002373)3.68117504
14Generalized tonic-clonic seizures (HP:0002069)3.62339250
15Action tremor (HP:0002345)3.50710931
16Papilledema (HP:0001085)3.45576381
17Depression (HP:0000716)3.22198724
18Ankle clonus (HP:0011448)3.16799941
19Abnormal eating behavior (HP:0100738)3.13150032
20Tetraplegia (HP:0002445)3.10387342
21Amblyopia (HP:0000646)3.05620232
22Poor eye contact (HP:0000817)3.05234768
23Hypokinesia (HP:0002375)3.03028583
24Limb dystonia (HP:0002451)2.94909605
25Cerebral inclusion bodies (HP:0100314)2.94003696
26Truncal ataxia (HP:0002078)2.92349713
27Anxiety (HP:0000739)2.91677260
28Broad-based gait (HP:0002136)2.90252711
29Polyphagia (HP:0002591)2.88932880
30Impaired social interactions (HP:0000735)2.75276121
31Abnormal social behavior (HP:0012433)2.75276121
32Dysdiadochokinesis (HP:0002075)2.71139279
33Insidious onset (HP:0003587)2.70906953
34Termporal pattern (HP:0011008)2.70906953
35Akinesia (HP:0002304)2.69897188
36Progressive inability to walk (HP:0002505)2.69471439
37Pheochromocytoma (HP:0002666)2.68438906
38Drooling (HP:0002307)2.67658561
39Excessive salivation (HP:0003781)2.67658561
40Abnormal mitochondria in muscle tissue (HP:0008316)2.60026093
41Hypoventilation (HP:0002791)2.54703534
42Upper limb muscle weakness (HP:0003484)2.53563508
43Atrophy/Degeneration involving motor neurons (HP:0007373)2.52481185
44Hyperventilation (HP:0002883)2.52104634
45Acute necrotizing encephalopathy (HP:0006965)2.51749048
46CNS hypomyelination (HP:0003429)2.51534401
47Amyotrophic lateral sclerosis (HP:0007354)2.50111208
48Neurofibrillary tangles (HP:0002185)2.48375590
49Agitation (HP:0000713)2.46702904
50Torticollis (HP:0000473)2.46017926
51Genetic anticipation (HP:0003743)2.45355606
52Impaired vibration sensation in the lower limbs (HP:0002166)2.45072983
53Epileptiform EEG discharges (HP:0011182)2.43902260
54Urinary urgency (HP:0000012)2.42379355
55Decreased activity of mitochondrial respiratory chain (HP:0008972)2.41912632
56Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.41912632
57Urinary bladder sphincter dysfunction (HP:0002839)2.41411575
58Diminished movement (HP:0002374)2.40608232
59EEG with generalized epileptiform discharges (HP:0011198)2.39266957
60Autoamputation (HP:0001218)2.38482155
61Neuroendocrine neoplasm (HP:0100634)2.37988395
62Degeneration of the lateral corticospinal tracts (HP:0002314)2.37969685
63Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.37969685
64Dysmetria (HP:0001310)2.36468861
65Slow saccadic eye movements (HP:0000514)2.36443800
66Hyperthyroidism (HP:0000836)2.35636923
67Sensory axonal neuropathy (HP:0003390)2.34266481
68Leukodystrophy (HP:0002415)2.33932440
69Gaze-evoked nystagmus (HP:0000640)2.33091652
70Abnormality of the anterior horn cell (HP:0006802)2.32955566
71Degeneration of anterior horn cells (HP:0002398)2.32955566
72Resting tremor (HP:0002322)2.32899319
73Abnormality of the lower motor neuron (HP:0002366)2.31604995
74Abnormality of glycolysis (HP:0004366)2.30933462
75Hypercortisolism (HP:0001578)2.30553675
76Sparse eyelashes (HP:0000653)2.29783428
77Inappropriate behavior (HP:0000719)2.29517627
78Apathy (HP:0000741)2.25933751
79Megalencephaly (HP:0001355)2.25751861
80Stereotypic behavior (HP:0000733)2.25432397
81Absent speech (HP:0001344)2.23342603
82Bradykinesia (HP:0002067)2.22684515
83Focal dystonia (HP:0004373)2.22286899
84Hand muscle atrophy (HP:0009130)2.21752796
85Growth hormone excess (HP:0000845)2.21290383
86Heterochromia iridis (HP:0001100)2.20904163
87Abnormality of binocular vision (HP:0011514)2.19794925
88Diplopia (HP:0000651)2.19794925
89Diminished motivation (HP:0000745)2.19483692
90Progressive macrocephaly (HP:0004481)2.18180591
91Microglossia (HP:0000171)2.17169943
92Hemiparesis (HP:0001269)2.15894335
93Inability to walk (HP:0002540)2.15072637
94Rigidity (HP:0002063)2.14150260
95Lower limb amyotrophy (HP:0007210)2.14032494
96Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.13632081
97Shoulder girdle muscle weakness (HP:0003547)2.12395055
98Postural instability (HP:0002172)2.11617062
99Increased serum pyruvate (HP:0003542)2.11017870
100Rough bone trabeculation (HP:0100670)2.09809970
101Rapidly progressive (HP:0003678)2.08261258
102Acute encephalopathy (HP:0006846)2.08031235
103Neoplasm of the peripheral nervous system (HP:0100007)2.07743748
104Hypsarrhythmia (HP:0002521)2.07596701
105Pointed chin (HP:0000307)2.07404589
106Choreoathetosis (HP:0001266)2.06235049
107Postnatal microcephaly (HP:0005484)2.05942338
108Craniofacial dystonia (HP:0012179)2.05840200
109Insomnia (HP:0100785)2.05829020
110Abnormal neuron morphology (HP:0012757)2.05461583
111Abnormality of the motor neurons (HP:0002450)2.05461583
112Impaired smooth pursuit (HP:0007772)2.03179445
113Central scotoma (HP:0000603)2.02750122
114Peripheral hypomyelination (HP:0007182)2.00886639
115Intention tremor (HP:0002080)2.00681948
116Failure to thrive in infancy (HP:0001531)1.99533524
117Lower limb muscle weakness (HP:0007340)1.98526492
118Spastic gait (HP:0002064)1.98140730
119Morphological abnormality of the pyramidal tract (HP:0002062)1.97878717
120Scanning speech (HP:0002168)1.96984756
121Fetal akinesia sequence (HP:0001989)1.95947888
122Neuronal loss in central nervous system (HP:0002529)1.94560441
123Delusions (HP:0000746)1.94379481
124Lissencephaly (HP:0001339)1.93081769
125Dysphonia (HP:0001618)1.92327374
126Upper limb amyotrophy (HP:0009129)1.91501710
127Distal upper limb amyotrophy (HP:0007149)1.91501710
128Long palpebral fissure (HP:0000637)1.91471402
129Distal sensory impairment (HP:0002936)1.91090888
130Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.90414069
131Spastic tetraparesis (HP:0001285)1.89600348
132Hyperparathyroidism (HP:0000843)1.88206711
133Aqueductal stenosis (HP:0002410)1.86438772
134Cortical dysplasia (HP:0002539)1.86307084
135Proximal placement of thumb (HP:0009623)1.86244121
136Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.85617344
137Hemiplegia (HP:0002301)1.84215005
138Abnormality of ocular smooth pursuit (HP:0000617)1.83818997
139Hypoplasia of the brainstem (HP:0002365)1.83404792
140Aplasia/Hypoplasia of the brainstem (HP:0007362)1.83404792
141Generalized myoclonic seizures (HP:0002123)1.83377163
142Glucose intolerance (HP:0000833)1.83303745
143Ventricular fibrillation (HP:0001663)1.82271478
144Spinal cord compression (HP:0002176)1.82250360
145Retinal dysplasia (HP:0007973)1.81203250
146Deviation of the thumb (HP:0009603)1.81079901
147Lower limb asymmetry (HP:0100559)1.79732665
148Menstrual irregularities (HP:0000858)1.78217836
149Impaired pain sensation (HP:0007328)1.78028584
150Abnormality of pain sensation (HP:0010832)1.78028584
151Multiple enchondromatosis (HP:0005701)1.77975324
152Congenital ichthyosiform erythroderma (HP:0007431)1.77896582
153Adrenal hypoplasia (HP:0000835)1.76826934
154Abnormality of the corticospinal tract (HP:0002492)1.76407520
155Annular pancreas (HP:0001734)1.76280178
156Gait ataxia (HP:0002066)1.76274722
157Obstructive sleep apnea (HP:0002870)1.75835860

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.21690743
2NTRK34.09295730
3MARK13.71336995
4TESK13.41366931
5MAP3K43.23519812
6EPHA43.10068439
7* MINK13.04661335
8BUB13.02888679
9MAP3K122.86898341
10MAP2K72.68876256
11KSR22.63618931
12PAK62.29594558
13TESK22.17669596
14KSR12.10831564
15MAP2K42.10437924
16EIF2AK12.08956973
17NTRK12.01401731
18DAPK21.97313537
19TSSK61.93353945
20RIPK41.88204920
21TRIM281.85214525
22PNCK1.84455127
23LATS21.76405617
24PLK21.75830794
25CAMKK11.68790021
26ARAF1.66044749
27FES1.60815350
28NTRK21.60178771
29EPHA21.51928463
30DAPK11.51119276
31GRK51.50837403
32CDK51.49644056
33NME21.46315078
34SIK21.39163457
35MST1R1.38737154
36CDK191.37588264
37PAK41.30934083
38PRKD31.30347869
39PBK1.28884240
40MAPK131.25943015
41NEK11.25606304
42CAMKK21.23062654
43MAP3K131.18277492
44STK381.16453248
45MST41.15734642
46FER1.15510632
47SCYL21.14241381
48RET1.13380350
49PTK2B1.12725774
50PHKG21.12431064
51PHKG11.12431064
52CDK181.10558158
53BRAF1.10369052
54PRKCG1.09266814
55* CDK141.08149540
56CASK1.06400726
57CDK151.06368579
58MAP3K21.06202234
59SRPK11.04621532
60UHMK11.04394674
61PRPF4B0.97530559
62RAF10.96768827
63NME10.96036655
64CDK11A0.94725796
65PTK20.93608975
66STK160.93592435
67PLK30.92253251
68PAK30.92089363
69EPHB10.91783964
70DYRK1A0.91439567
71CDC70.89545136
72CSNK1G20.84621044
73VRK20.83685475
74LIMK10.83377335
75TNIK0.82738208
76ABL20.82690413
77RIPK10.82437885
78* CAMK2A0.80684601
79CAMK1G0.79515337
80CAMK10.79347201
81LMTK20.79026442
82TAOK10.75101867
83TYRO30.73807651
84MAP2K10.73220504
85STK110.70299475
86PAK10.69034406
87MAP3K10.67580808
88SIK30.63717811
89RPS6KA40.60913679
90TTK0.60856933
91EIF2AK20.59685819
92PRKCI0.58555987
93NEK60.58244315
94PLK10.57504793
95CAMK2B0.56338653
96ERBB30.53748761
97ALK0.52991326
98FGR0.52214068
99MAP3K80.51852245
100ERBB40.51085351
101CLK10.50855519
102TAF10.50707538
103PRKCE0.49848513
104MARK20.49376890
105AURKA0.48473221
106WEE10.47546705
107CSNK1E0.46527741
108PRKCH0.45604947
109MAP3K60.44210106
110FYN0.44010810
111PDK10.43272432
112BCR0.42758048
113AURKB0.40830810
114PDPK10.40693188
115CSNK1G30.40588133
116DYRK20.39630883
117MAPK100.38440093
118DAPK30.38356959
119IRAK30.37272696
120OXSR10.35753759
121SGK2230.34814581
122SGK4940.34814581
123MAP3K110.34611895
124* PRKCZ0.34430975
125SMG10.33719796
126SGK10.32691456
127ROCK20.32409270
128TRIB30.32250918
129ADRBK10.31857506
130MOS0.31372496
131DMPK0.30516006
132CSNK1A1L0.30479403
133STK100.30374967
134RPS6KA20.30012836
135* RPS6KA30.28111283
136MAP3K50.27719552
137SRC0.27442406
138BRSK10.26574680
139WNK30.24653734
140BMPR20.24518613
141CAMK2G0.24272164

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.22220806
2Nicotine addiction_Homo sapiens_hsa050333.52727989
3Synaptic vesicle cycle_Homo sapiens_hsa047213.42712583
4GABAergic synapse_Homo sapiens_hsa047272.64727760
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.61638286
6Long-term potentiation_Homo sapiens_hsa047202.49680598
7Circadian entrainment_Homo sapiens_hsa047132.49595968
8Olfactory transduction_Homo sapiens_hsa047402.44282413
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.42708560
10Morphine addiction_Homo sapiens_hsa050322.39369233
11Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.27664506
12Dopaminergic synapse_Homo sapiens_hsa047282.23510687
13Glutamatergic synapse_Homo sapiens_hsa047242.21238964
14Amphetamine addiction_Homo sapiens_hsa050312.13379438
15Salivary secretion_Homo sapiens_hsa049701.95413106
16DNA replication_Homo sapiens_hsa030301.89249378
17Cholinergic synapse_Homo sapiens_hsa047251.87282744
18Renin secretion_Homo sapiens_hsa049241.86657197
19Vitamin B6 metabolism_Homo sapiens_hsa007501.80142274
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.78434757
21Mismatch repair_Homo sapiens_hsa034301.73717019
22Insulin secretion_Homo sapiens_hsa049111.72820932
23Serotonergic synapse_Homo sapiens_hsa047261.71137512
24Long-term depression_Homo sapiens_hsa047301.69542558
25Gastric acid secretion_Homo sapiens_hsa049711.65616743
26Oxytocin signaling pathway_Homo sapiens_hsa049211.65215014
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.63571032
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.62635568
29Taste transduction_Homo sapiens_hsa047421.61923577
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61032918
31Shigellosis_Homo sapiens_hsa051311.60170443
32Collecting duct acid secretion_Homo sapiens_hsa049661.55752087
33Folate biosynthesis_Homo sapiens_hsa007901.54438706
34Gap junction_Homo sapiens_hsa045401.53207711
35GnRH signaling pathway_Homo sapiens_hsa049121.51184025
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49672704
37Cocaine addiction_Homo sapiens_hsa050301.45708785
38Calcium signaling pathway_Homo sapiens_hsa040201.33137841
39Fatty acid elongation_Homo sapiens_hsa000621.31782783
40Protein export_Homo sapiens_hsa030601.31087932
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30170883
42Glioma_Homo sapiens_hsa052141.29742504
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28200188
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24143957
45Base excision repair_Homo sapiens_hsa034101.22476079
46Estrogen signaling pathway_Homo sapiens_hsa049151.22226995
47Spliceosome_Homo sapiens_hsa030401.20803635
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20260204
49Axon guidance_Homo sapiens_hsa043601.19936671
50Vibrio cholerae infection_Homo sapiens_hsa051101.15273256
51Huntingtons disease_Homo sapiens_hsa050161.14860277
52cAMP signaling pathway_Homo sapiens_hsa040241.12358116
53RNA transport_Homo sapiens_hsa030131.09219718
54* Oocyte meiosis_Homo sapiens_hsa041141.08701228
55Thyroid cancer_Homo sapiens_hsa052161.07436156
56Melanogenesis_Homo sapiens_hsa049161.05904962
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05659267
58RNA polymerase_Homo sapiens_hsa030201.05537979
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04217070
60Cardiac muscle contraction_Homo sapiens_hsa042601.03665984
61cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02846021
62ErbB signaling pathway_Homo sapiens_hsa040121.02320854
63Type II diabetes mellitus_Homo sapiens_hsa049300.96611247
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96551672
65mRNA surveillance pathway_Homo sapiens_hsa030150.94581824
66Pentose phosphate pathway_Homo sapiens_hsa000300.92355614
67VEGF signaling pathway_Homo sapiens_hsa043700.92073848
68* Cell cycle_Homo sapiens_hsa041100.91176341
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.87995243
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.87290192
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86493415
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.85382800
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85050318
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84239817
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79314590
76Pyrimidine metabolism_Homo sapiens_hsa002400.78996243
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76367595
78Choline metabolism in cancer_Homo sapiens_hsa052310.75526322
79Dorso-ventral axis formation_Homo sapiens_hsa043200.74161968
80Non-homologous end-joining_Homo sapiens_hsa034500.71245339
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.71011810
82Pyruvate metabolism_Homo sapiens_hsa006200.70391690
83Nucleotide excision repair_Homo sapiens_hsa034200.67925703
84Renal cell carcinoma_Homo sapiens_hsa052110.67398786
85Thyroid hormone synthesis_Homo sapiens_hsa049180.66530293
86Endometrial cancer_Homo sapiens_hsa052130.66350343
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65968257
88Phototransduction_Homo sapiens_hsa047440.65772240
89MAPK signaling pathway_Homo sapiens_hsa040100.65716694
90Endocytosis_Homo sapiens_hsa041440.65335222
91Colorectal cancer_Homo sapiens_hsa052100.65260583
92Carbon metabolism_Homo sapiens_hsa012000.65067102
93Dilated cardiomyopathy_Homo sapiens_hsa054140.63895088
94Biosynthesis of amino acids_Homo sapiens_hsa012300.63600884
95Ras signaling pathway_Homo sapiens_hsa040140.63483285
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63263043
97Alzheimers disease_Homo sapiens_hsa050100.61636362
98Pancreatic cancer_Homo sapiens_hsa052120.61575092
99Phagosome_Homo sapiens_hsa041450.61212088
100Pancreatic secretion_Homo sapiens_hsa049720.61025956
101Rap1 signaling pathway_Homo sapiens_hsa040150.60506212
102mTOR signaling pathway_Homo sapiens_hsa041500.59890226
103Insulin signaling pathway_Homo sapiens_hsa049100.59709246
104Adherens junction_Homo sapiens_hsa045200.59232768
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58853559
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58001800
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57927718
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.57380171
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57265883
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57123699
111Ribosome_Homo sapiens_hsa030100.56775204
112Glucagon signaling pathway_Homo sapiens_hsa049220.54937950
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54450051
114Non-small cell lung cancer_Homo sapiens_hsa052230.50621146
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50220890
116Wnt signaling pathway_Homo sapiens_hsa043100.50096575
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50023101
118Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47782099
119N-Glycan biosynthesis_Homo sapiens_hsa005100.47752409
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.47653892
121Alcoholism_Homo sapiens_hsa050340.47266017
122Parkinsons disease_Homo sapiens_hsa050120.46593744
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45423591
124* Epstein-Barr virus infection_Homo sapiens_hsa051690.44909133
125Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43960496
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41321724
127Oxidative phosphorylation_Homo sapiens_hsa001900.41312378
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41205982
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41112268
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41047929
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40748913
132Prion diseases_Homo sapiens_hsa050200.40510604
133Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38055917
134Circadian rhythm_Homo sapiens_hsa047100.37280555
135Platelet activation_Homo sapiens_hsa046110.36452539
136Melanoma_Homo sapiens_hsa052180.36447909
137Salmonella infection_Homo sapiens_hsa051320.36139092
138Inositol phosphate metabolism_Homo sapiens_hsa005620.35168041
139AMPK signaling pathway_Homo sapiens_hsa041520.34779950
140Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34419869
141Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34091388
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32695391
143RNA degradation_Homo sapiens_hsa030180.32154709
144Steroid biosynthesis_Homo sapiens_hsa001000.30372082

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