YTHDF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.36502399
2nuclear pore organization (GO:0006999)5.28765026
3DNA unwinding involved in DNA replication (GO:0006268)5.22874555
4pre-miRNA processing (GO:0031054)4.95912416
5heterochromatin organization (GO:0070828)4.81990034
6regulation of posttranscriptional gene silencing (GO:0060147)4.32807694
7regulation of gene silencing by miRNA (GO:0060964)4.32807694
8regulation of gene silencing by RNA (GO:0060966)4.32807694
9folic acid-containing compound biosynthetic process (GO:0009396)4.27158243
10protein localization to kinetochore (GO:0034501)4.24079989
11mitotic nuclear envelope disassembly (GO:0007077)4.16363421
12formation of translation preinitiation complex (GO:0001731)4.14269344
13regulation of RNA export from nucleus (GO:0046831)4.13932793
14mitotic sister chromatid cohesion (GO:0007064)4.03914684
15negative regulation of histone methylation (GO:0031061)3.99039277
16nuclear envelope disassembly (GO:0051081)3.97705929
17membrane disassembly (GO:0030397)3.97705929
18cellular protein complex localization (GO:0034629)3.93721848
19regulation of translational fidelity (GO:0006450)3.82036541
20regulation of histone H3-K9 methylation (GO:0051570)3.81559320
21negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.73208822
22DNA replication-dependent nucleosome assembly (GO:0006335)3.72421277
23DNA replication-dependent nucleosome organization (GO:0034723)3.72421277
24protein complex localization (GO:0031503)3.70092471
25ribosomal small subunit biogenesis (GO:0042274)3.66556023
26DNA replication initiation (GO:0006270)3.65215461
27DNA duplex unwinding (GO:0032508)3.62854973
28pore complex assembly (GO:0046931)3.62114390
29DNA geometric change (GO:0032392)3.58522862
30peptidyl-arginine omega-N-methylation (GO:0035247)3.56635868
31regulation of mammary gland epithelial cell proliferation (GO:0033599)3.56472027
32regulation of NFAT protein import into nucleus (GO:0051532)3.55187860
33chromatin assembly (GO:0031497)3.50548388
34regulation of translational termination (GO:0006449)3.50399602
35IMP biosynthetic process (GO:0006188)3.47894478
36COPI coating of Golgi vesicle (GO:0048205)3.46384481
37Golgi transport vesicle coating (GO:0048200)3.46384481
38mitotic chromosome condensation (GO:0007076)3.44348165
39protein localization to chromosome, centromeric region (GO:0071459)3.42739674
40negative regulation of RNA splicing (GO:0033119)3.39716961
41regulation of early endosome to late endosome transport (GO:2000641)3.38900980
42positive regulation of SMAD protein import into nucleus (GO:0060391)3.37678169
43maturation of SSU-rRNA (GO:0030490)3.35773344
44RNA stabilization (GO:0043489)3.35696047
45mRNA stabilization (GO:0048255)3.35696047
46dosage compensation (GO:0007549)3.34787575
47histone H2A monoubiquitination (GO:0035518)3.33262825
48mitotic metaphase plate congression (GO:0007080)3.31992175
49negative regulation of mRNA processing (GO:0050686)3.26368653
50maternal placenta development (GO:0001893)3.25170814
51regulation of nucleobase-containing compound transport (GO:0032239)3.23229660
52peptidyl-arginine N-methylation (GO:0035246)3.22363926
53peptidyl-arginine methylation (GO:0018216)3.22363926
54adherens junction assembly (GO:0034333)3.21251036
55sister chromatid segregation (GO:0000819)3.21046500
56positive regulation of chromosome segregation (GO:0051984)3.20143709
57nuclear envelope organization (GO:0006998)3.18915264
58translational termination (GO:0006415)3.18126741
59negative regulation of mRNA metabolic process (GO:1903312)3.17256353
60translational initiation (GO:0006413)3.15516432
61viral transcription (GO:0019083)3.15355550
62nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.13721360
63trophectodermal cell differentiation (GO:0001829)3.12262880
64regulation of spindle organization (GO:0090224)3.12260282
65IMP metabolic process (GO:0046040)3.11489709
66mitotic sister chromatid segregation (GO:0000070)3.10341918
67focal adhesion assembly (GO:0048041)3.10325903
68cell-substrate adherens junction assembly (GO:0007045)3.10325903
69positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.10303690
70proline biosynthetic process (GO:0006561)3.08403402
71DNA replication checkpoint (GO:0000076)3.06022861
72spliceosomal tri-snRNP complex assembly (GO:0000244)3.04493741
73DNA strand elongation involved in DNA replication (GO:0006271)3.04452502
74RNA localization (GO:0006403)3.03700893
75alternative mRNA splicing, via spliceosome (GO:0000380)3.03166550
76histone H4-K12 acetylation (GO:0043983)3.02278733
77ribosome assembly (GO:0042255)3.01854812
78nucleobase biosynthetic process (GO:0046112)3.01599765
79maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.00549817
80peptidyl-lysine dimethylation (GO:0018027)2.99790811
81regulation of sister chromatid cohesion (GO:0007063)2.99774032
82regulation of helicase activity (GO:0051095)2.98116515
83mRNA transport (GO:0051028)2.97799984
84positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.96967777
85positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.96967777
86positive regulation of mitotic sister chromatid separation (GO:1901970)2.96967777
873-UTR-mediated mRNA stabilization (GO:0070935)2.96478122
88gene silencing by RNA (GO:0031047)2.92631891
89paraxial mesoderm development (GO:0048339)2.92435459
90histone arginine methylation (GO:0034969)2.92416493
91RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.92310790
92mRNA splicing, via spliceosome (GO:0000398)2.92310790
93RNA splicing, via transesterification reactions (GO:0000375)2.91472124
94NLS-bearing protein import into nucleus (GO:0006607)2.88563164
95ribosome biogenesis (GO:0042254)2.87989849
96protein export from nucleus (GO:0006611)2.87572581
97glucocorticoid receptor signaling pathway (GO:0042921)2.86130059
98regulation of mRNA stability (GO:0043488)2.85676581
99protein retention in ER lumen (GO:0006621)2.85193043
100metaphase plate congression (GO:0051310)2.84899401
101DNA strand elongation (GO:0022616)2.84019937
102regulation of chromatin binding (GO:0035561)2.83642857
103chromosome condensation (GO:0030261)2.83575105
104regulation of gene silencing (GO:0060968)2.83565577
105protein localization to microtubule (GO:0035372)2.83341873
106translational elongation (GO:0006414)2.82378313
107planar cell polarity pathway involved in neural tube closure (GO:0090179)2.82172338
108regulation of SMAD protein import into nucleus (GO:0060390)2.81244438
109regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.80726523
110chromatin assembly or disassembly (GO:0006333)2.78175315
111negative regulation of histone modification (GO:0031057)2.78010494
112termination of RNA polymerase II transcription (GO:0006369)2.77246802
113somatic hypermutation of immunoglobulin genes (GO:0016446)2.77050924
114somatic diversification of immune receptors via somatic mutation (GO:0002566)2.77050924
115regulation of mitotic spindle organization (GO:0060236)2.75933998
116polarized epithelial cell differentiation (GO:0030859)2.75809864
117negative regulation of DNA repair (GO:0045738)2.73871211
118apoptotic process involved in morphogenesis (GO:0060561)2.73649809
119regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.73643386
120nucleic acid transport (GO:0050657)2.73032988
121RNA transport (GO:0050658)2.73032988
122establishment of RNA localization (GO:0051236)2.73032988
123establishment of apical/basal cell polarity (GO:0035089)2.72755831
124DNA conformation change (GO:0071103)2.72730286
125activation of Rac GTPase activity (GO:0032863)2.67303251
126trophoblast giant cell differentiation (GO:0060707)2.66746571
127histone H2B ubiquitination (GO:0033523)2.62977905
128positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.62626714
129regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.62626714
130body morphogenesis (GO:0010171)2.61099085
131positive regulation of DNA-dependent DNA replication (GO:2000105)2.60957784
132desmosome organization (GO:0002934)2.59349252
133regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.58978478
134regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.58774980
135hippo signaling (GO:0035329)2.56333641
136embryonic process involved in female pregnancy (GO:0060136)2.53306815
137regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.51659390
138positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.49765772
139epithelial cell-cell adhesion (GO:0090136)2.49101832
140protein-DNA complex disassembly (GO:0032986)2.48948163
141nucleosome disassembly (GO:0006337)2.48948163
142positive regulation of nuclease activity (GO:0032075)2.48334851
143notochord development (GO:0030903)2.48115851
144ear development (GO:0043583)2.47523384
145regulation of RNA stability (GO:0043487)2.47042385
146protein localization to endosome (GO:0036010)2.45665337
147regulation of glucose import in response to insulin stimulus (GO:2001273)2.45213265
148regulation of histone H3-K27 methylation (GO:0061085)2.45143783
149epithelial cell differentiation involved in prostate gland development (GO:0060742)2.44661766
150activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.42911272
151histone H3-K36 demethylation (GO:0070544)2.42379378
152DNA topological change (GO:0006265)2.41716775
153branching involved in mammary gland duct morphogenesis (GO:0060444)2.40592052
154ribonucleoprotein complex biogenesis (GO:0022613)2.39830247
155DNA synthesis involved in DNA repair (GO:0000731)2.38212334
156retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.37453083
157receptor recycling (GO:0001881)2.36916050
158DNA packaging (GO:0006323)2.33666119
159regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.32670045

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.52209277
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.51654539
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.92437635
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.79320671
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.31396912
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.28150404
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.20064930
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.04464245
9MYC_22102868_ChIP-Seq_BL_Human2.93855465
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84794760
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.58967985
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.44725631
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.31907383
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.08678176
15XRN2_22483619_ChIP-Seq_HELA_Human2.08504828
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.04002170
17AR_21909140_ChIP-Seq_LNCAP_Human2.02032671
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.00268823
19NELFA_20434984_ChIP-Seq_ESCs_Mouse1.98642487
20CLOCK_20551151_ChIP-Seq_293T_Human1.94987703
21KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.90476051
22KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.90476051
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.90476051
24MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87458330
25SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.85851441
26RACK7_27058665_Chip-Seq_MCF-7_Human1.82165542
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.79946400
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.77184462
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.74368707
30CIITA_25753668_ChIP-Seq_RAJI_Human1.74367226
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.71891656
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68708028
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.68042258
34SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.67389998
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.60553141
36ETS1_20019798_ChIP-Seq_JURKAT_Human1.60381103
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59210140
38* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58489409
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57511097
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.56953487
41KDM2B_26808549_Chip-Seq_K562_Human1.56306764
42ZNF263_19887448_ChIP-Seq_K562_Human1.56100716
43VDR_21846776_ChIP-Seq_THP-1_Human1.54734038
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53405623
45TCF3_18692474_ChIP-Seq_MEFs_Mouse1.52794660
46* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51698379
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.51271054
48KLF4_18555785_ChIP-Seq_MESCs_Mouse1.49919193
49ESR1_15608294_ChIP-ChIP_MCF-7_Human1.49579488
50TTF2_22483619_ChIP-Seq_HELA_Human1.49118839
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47901242
52KDM5A_27292631_Chip-Seq_BREAST_Human1.47610851
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45490808
54LXR_22292898_ChIP-Seq_THP-1_Human1.43452364
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.42343670
56KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.41991171
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40968273
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.39385474
59DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.39352507
60PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.38113254
61HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37787257
62TCF7_22412390_ChIP-Seq_EML_Mouse1.37758910
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35246606
64DCP1A_22483619_ChIP-Seq_HELA_Human1.34814082
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32880840
66E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32525108
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32293603
68VDR_23849224_ChIP-Seq_CD4+_Human1.31867105
69P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31353088
70NANOG_21062744_ChIP-ChIP_HESCs_Human1.30787957
71* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30348699
72EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28167149
73* TFEB_21752829_ChIP-Seq_HELA_Human1.27302180
74GABP_19822575_ChIP-Seq_HepG2_Human1.25850964
75KDM2B_26808549_Chip-Seq_DND41_Human1.24652582
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23697380
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23621899
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22914047
79* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22820220
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22693876
81YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22653832
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22085945
83NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.21506737
84NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20586871
85FOXP3_21729870_ChIP-Seq_TREG_Human1.19952828
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19772591
87SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18945283
88* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17760907
89SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.17672578
90* CHD1_26751641_Chip-Seq_LNCaP_Human1.17052120
91TCF3_18692474_ChIP-Seq_MESCs_Mouse1.16184252
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14966926
93* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14548354
94DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.13951195
95* ATF3_27146783_Chip-Seq_COLON_Human1.13837795
96PKCTHETA_26484144_Chip-Seq_BREAST_Human1.13031364
97SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12477013
98SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12172066
99STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11387608
100ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10854464
101ELK3_25401928_ChIP-Seq_HUVEC_Human1.10031939
102SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08803334
103POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08731625
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07999092
105KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07162764
106* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.07050435
107ESR1_21235772_ChIP-Seq_MCF-7_Human1.07008119
108RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06865214
109HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06772111
110ERG_21242973_ChIP-ChIP_JURKAT_Human1.06444393
111GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.06384857
112GABP_17652178_ChIP-ChIP_JURKAT_Human1.05956622
113CREB1_26743006_Chip-Seq_LNCaP_Human1.05485696
114KDM2B_26808549_Chip-Seq_JURKAT_Human1.04875882
115CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04489125
116UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04387299
117TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04255541
118* RUNX1_27514584_Chip-Seq_MCF-7_Human1.03928271
119HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03923214
120SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03124955
121TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01719674
122NCOR1_26117541_ChIP-Seq_K562_Human1.01719176
123NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.01638685
124E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01635640
125THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01409388
126TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01222322
127NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99861261
128RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99747197
129UTX_26944678_Chip-Seq_JUKART_Human0.99361451
130THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98877178
131ELK1_19687146_ChIP-ChIP_HELA_Human0.97688547
132STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97056473
133OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95523790
134CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94043201
135SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94005232

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004957_abnormal_blastocyst_morpholog3.86132806
2MP0010352_gastrointestinal_tract_polyps3.85564016
3MP0003111_abnormal_nucleus_morphology3.22994254
4MP0008057_abnormal_DNA_replication3.20221624
5MP0003693_abnormal_embryo_hatching3.20140319
6MP0003705_abnormal_hypodermis_morpholog3.17990551
7MP0010094_abnormal_chromosome_stability3.15545041
8MP0003077_abnormal_cell_cycle2.93398027
9MP0003123_paternal_imprinting2.83209833
10MP0005076_abnormal_cell_differentiation2.77372588
11MP0001730_embryonic_growth_arrest2.61601453
12MP0002796_impaired_skin_barrier2.46492002
13MP0005451_abnormal_body_composition2.45415407
14MP0000350_abnormal_cell_proliferation2.26549744
15MP0002084_abnormal_developmental_patter2.18713025
16MP0004197_abnormal_fetal_growth/weight/2.15201017
17MP0000537_abnormal_urethra_morphology2.15172035
18MP0001672_abnormal_embryogenesis/_devel2.14488880
19MP0005380_embryogenesis_phenotype2.14488880
20MP0001697_abnormal_embryo_size2.08254236
21MP0010307_abnormal_tumor_latency2.05645121
22MP0003984_embryonic_growth_retardation2.04331268
23MP0002088_abnormal_embryonic_growth/wei2.03570864
24MP0002085_abnormal_embryonic_tissue2.03400586
25MP0002086_abnormal_extraembryonic_tissu2.02906111
26MP0005257_abnormal_intraocular_pressure2.00917909
27MP0003567_abnormal_fetal_cardiomyocyte2.00567667
28MP0003119_abnormal_digestive_system1.95069335
29MP0008932_abnormal_embryonic_tissue1.94353341
30MP0009053_abnormal_anal_canal1.85851792
31MP0003890_abnormal_embryonic-extraembry1.82725048
32MP0005409_darkened_coat_color1.80978110
33MP0003453_abnormal_keratinocyte_physiol1.77990843
34MP0008007_abnormal_cellular_replicative1.74799044
35MP0002080_prenatal_lethality1.73637729
36MP0008877_abnormal_DNA_methylation1.72414174
37MP0008058_abnormal_DNA_repair1.67664662
38MP0009379_abnormal_foot_pigmentation1.63391166
39MP0002089_abnormal_postnatal_growth/wei1.61584113
40MP0003121_genomic_imprinting1.60995262
41MP0000566_synostosis1.59388691
42MP0010234_abnormal_vibrissa_follicle1.54737993
43MP0005623_abnormal_meninges_morphology1.53228737
44MP0010030_abnormal_orbit_morphology1.50560880
45MP0005058_abnormal_lysosome_morphology1.48352029
46MP0003566_abnormal_cell_adhesion1.45616653
47MP0002396_abnormal_hematopoietic_system1.39948238
48MP0000733_abnormal_muscle_development1.39716434
49MP0004808_abnormal_hematopoietic_stem1.35206729
50MP0003303_peritoneal_inflammation1.34520065
51MP0001915_intracranial_hemorrhage1.33005378
52MP0009672_abnormal_birth_weight1.32533229
53MP0009278_abnormal_bone_marrow1.30518250
54MP0001293_anophthalmia1.28304758
55MP0000490_abnormal_crypts_of1.27470195
56MP0000428_abnormal_craniofacial_morphol1.26187299
57MP0006054_spinal_hemorrhage1.24375843
58MP0004185_abnormal_adipocyte_glucose1.24343891
59MP0001849_ear_inflammation1.24076454
60MP0000579_abnormal_nail_morphology1.20031965
61MP0009703_decreased_birth_body1.19045581
62MP0000678_abnormal_parathyroid_gland1.17699270
63MP0000313_abnormal_cell_death1.16316584
64MP0000762_abnormal_tongue_morphology1.14753188
65MP0004858_abnormal_nervous_system1.13885971
66MP0002019_abnormal_tumor_incidence1.09746983
67MP0002925_abnormal_cardiovascular_devel1.07979594
68MP0001348_abnormal_lacrimal_gland1.04315125
69MP0002098_abnormal_vibrissa_morphology1.03084645
70MP0003935_abnormal_craniofacial_develop1.03046829
71MP0008260_abnormal_autophagy1.00858657
72MP0003937_abnormal_limbs/digits/tail_de1.00516851
73MP0000462_abnormal_digestive_system0.99807779
74MP0000377_abnormal_hair_follicle0.99297550
75MP0002653_abnormal_ependyma_morphology0.99187256
76MP0002060_abnormal_skin_morphology0.98860968
77MP0002111_abnormal_tail_morphology0.98596650
78MP0000432_abnormal_head_morphology0.98190564
79MP0005666_abnormal_adipose_tissue0.97999064
80MP0001216_abnormal_epidermal_layer0.97790784
81MP0002877_abnormal_melanocyte_morpholog0.97734419
82MP0000703_abnormal_thymus_morphology0.97246952
83MP0001545_abnormal_hematopoietic_system0.95506824
84MP0005397_hematopoietic_system_phenotyp0.95506824
85MP0008770_decreased_survivor_rate0.95086930
86MP0005023_abnormal_wound_healing0.94595381
87MP0004133_heterotaxia0.94206043
88MP0001340_abnormal_eyelid_morphology0.93359307
89MP0002249_abnormal_larynx_morphology0.93170501
90MP0003786_premature_aging0.93017574
91MP0003115_abnormal_respiratory_system0.93011753
92MP0002697_abnormal_eye_size0.92615056
93MP0003221_abnormal_cardiomyocyte_apopto0.92313078
94MP0001727_abnormal_embryo_implantation0.91637102
95MP0000627_abnormal_mammary_gland0.90126143
96MP0005367_renal/urinary_system_phenotyp0.89254419
97MP0000516_abnormal_urinary_system0.89254419
98MP0003861_abnormal_nervous_system0.88986048
99MP0006292_abnormal_olfactory_placode0.88398222
100MP0004233_abnormal_muscle_weight0.87856482
101MP0003315_abnormal_perineum_morphology0.87102870
102MP0002092_abnormal_eye_morphology0.87017865
103MP0009840_abnormal_foam_cell0.82725058
104MP0000266_abnormal_heart_morphology0.82680024
105MP0001145_abnormal_male_reproductive0.81931795
106MP0001286_abnormal_eye_development0.80846514
107MP0004782_abnormal_surfactant_physiolog0.80645869
108MP0002116_abnormal_craniofacial_bone0.80196800
109MP0003385_abnormal_body_wall0.80180908
110MP0010678_abnormal_skin_adnexa0.79932512
111MP0005248_abnormal_Harderian_gland0.79092986
112MP0005187_abnormal_penis_morphology0.79010199
113MP0003942_abnormal_urinary_system0.78757661
114MP0002210_abnormal_sex_determination0.78436384
115MP0010630_abnormal_cardiac_muscle0.77674718
116MP0003941_abnormal_skin_development0.77547208
117MP0008961_abnormal_basal_metabolism0.76337658
118MP0005621_abnormal_cell_physiology0.75874450
119MP0003718_maternal_effect0.75675178
120MP0000858_altered_metastatic_potential0.75159813
121MP0002932_abnormal_joint_morphology0.74938697
122MP0003755_abnormal_palate_morphology0.73994506
123MP0005384_cellular_phenotype0.73228059
124MP0000534_abnormal_ureter_morphology0.72952811
125MP0004264_abnormal_extraembryonic_tissu0.71778792
126MP0009333_abnormal_splenocyte_physiolog0.70698003
127MP0005197_abnormal_uvea_morphology0.69724965
128MP0003448_altered_tumor_morphology0.69170455
129MP0003122_maternal_imprinting0.69084585
130MP0000477_abnormal_intestine_morphology0.68469799
131MP0003091_abnormal_cell_migration0.64800215
132MP0000750_abnormal_muscle_regeneration0.64742025
133MP0002398_abnormal_bone_marrow0.64353945
134MP0005501_abnormal_skin_physiology0.64156564

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.16967508
2Colon cancer (HP:0003003)3.58664075
3Astrocytoma (HP:0009592)3.26178715
4Abnormality of the astrocytes (HP:0100707)3.26178715
5Proximal placement of thumb (HP:0009623)3.23714977
6Medulloblastoma (HP:0002885)3.14905049
7Deviation of the thumb (HP:0009603)3.13773209
8Selective tooth agenesis (HP:0001592)2.93405287
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.89994923
10Short 4th metacarpal (HP:0010044)2.89994923
11Rhabdomyosarcoma (HP:0002859)2.87779356
12Basal cell carcinoma (HP:0002671)2.82431018
13Volvulus (HP:0002580)2.75111280
14Asymmetry of the thorax (HP:0001555)2.74610308
15Neoplasm of striated muscle (HP:0009728)2.72340795
16Septate vagina (HP:0001153)2.68321044
17Facial hemangioma (HP:0000329)2.64382849
18Long palpebral fissure (HP:0000637)2.63956781
19Neoplasm of the oral cavity (HP:0100649)2.61587876
20Abnormality of the labia minora (HP:0012880)2.58075399
21Ankyloglossia (HP:0010296)2.57793374
22Agnosia (HP:0010524)2.54190885
23Supernumerary ribs (HP:0005815)2.54137777
24Biliary tract neoplasm (HP:0100574)2.53923758
25Gastrointestinal carcinoma (HP:0002672)2.52969625
26Malignant gastrointestinal tract tumors (HP:0006749)2.52969625
27Glioma (HP:0009733)2.48453906
28Flat acetabular roof (HP:0003180)2.48431488
29Insomnia (HP:0100785)2.45899409
30Adenoma sebaceum (HP:0009720)2.43354115
31Angiofibromas (HP:0010615)2.43354115
32Rectal prolapse (HP:0002035)2.41668736
33Birth length less than 3rd percentile (HP:0003561)2.39238480
34Deep palmar crease (HP:0006191)2.38750223
35Overriding aorta (HP:0002623)2.37556806
36Atresia of the external auditory canal (HP:0000413)2.36502882
37Increased nuchal translucency (HP:0010880)2.35657389
38Heterotopia (HP:0002282)2.33131913
39Missing ribs (HP:0000921)2.30882418
40Supernumerary bones of the axial skeleton (HP:0009144)2.30202384
41Achilles tendon contracture (HP:0001771)2.30175079
42Degeneration of anterior horn cells (HP:0002398)2.30113010
43Abnormality of the anterior horn cell (HP:0006802)2.30113010
44Abnormality of the distal phalanx of the thumb (HP:0009617)2.29966393
45Progressive muscle weakness (HP:0003323)2.29579710
46Trismus (HP:0000211)2.24524186
47Abnormality of the 4th metacarpal (HP:0010012)2.24061056
48Long eyelashes (HP:0000527)2.24049539
49Overlapping toe (HP:0001845)2.22225105
50Shallow orbits (HP:0000586)2.20037441
51Broad thumb (HP:0011304)2.18925638
52Breast hypoplasia (HP:0003187)2.17561007
53Arnold-Chiari malformation (HP:0002308)2.15571137
54Aplasia/Hypoplasia of the sacrum (HP:0008517)2.14420714
55High pitched voice (HP:0001620)2.10857005
56Genu recurvatum (HP:0002816)2.10194965
57Skin tags (HP:0010609)2.10023826
58Abnormality of the Achilles tendon (HP:0005109)2.08459112
59Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.08128480
60Short 1st metacarpal (HP:0010034)2.08128480
61Fibroma (HP:0010614)2.07837061
62Abnormal number of incisors (HP:0011064)2.07812729
63Patellar aplasia (HP:0006443)2.07141629
64Increased density of long bones (HP:0006392)2.07055421
65Multiple enchondromatosis (HP:0005701)2.06952969
66Progressive external ophthalmoplegia (HP:0000590)2.06930837
67Reticulocytopenia (HP:0001896)2.06325879
68Abnormality of the phalanges of the hallux (HP:0010057)2.04319302
69Short phalanx of the thumb (HP:0009660)2.04259734
70Fibrous tissue neoplasm (HP:0012316)2.03971624
71Back pain (HP:0003418)2.03045447
72Hyperparathyroidism (HP:0000843)2.02652274
73Pseudobulbar signs (HP:0002200)2.01159533
74Prominent nose (HP:0000448)2.00564539
7511 pairs of ribs (HP:0000878)2.00531863
76Absent radius (HP:0003974)2.00472950
77Protrusio acetabuli (HP:0003179)2.00074065
78Amaurosis fugax (HP:0100576)1.98484850
79Deep philtrum (HP:0002002)1.98405488
80Elfin facies (HP:0004428)1.97644040
81Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.97059593
82Rib fusion (HP:0000902)1.96956695
83Abnormality of oral frenula (HP:0000190)1.96894341
84Patellar dislocation (HP:0002999)1.96509969
85Leiomyosarcoma (HP:0100243)1.96233800
86Uterine leiomyosarcoma (HP:0002891)1.96233800
87Pelvic girdle muscle weakness (HP:0003749)1.95837112
88Disproportionate tall stature (HP:0001519)1.95636440
89Abnormality of the salivary glands (HP:0010286)1.95297918
90Vertebral fusion (HP:0002948)1.94634280
91Aplasia/hypoplasia of the humerus (HP:0006507)1.94397783
92Preauricular skin tag (HP:0000384)1.94186198
93Intestinal polyp (HP:0005266)1.94100000
94High anterior hairline (HP:0009890)1.93077084
95Neoplasm of the pancreas (HP:0002894)1.92860906
96Cubitus valgus (HP:0002967)1.92808191
97Bowel incontinence (HP:0002607)1.92149396
98Aplasia/Hypoplasia of the patella (HP:0006498)1.91806396
99Broad palm (HP:0001169)1.89471063
100Atrophy/Degeneration involving motor neurons (HP:0007373)1.89077966
101Deep venous thrombosis (HP:0002625)1.87735561
102Renal duplication (HP:0000075)1.85881447
103Vertebral arch anomaly (HP:0008438)1.85532483
104Abnormality of the calcaneus (HP:0008364)1.85285294
105Annular pancreas (HP:0001734)1.85191876
106Uterine neoplasm (HP:0010784)1.84421439
107Carpal bone hypoplasia (HP:0001498)1.84070932
108Turricephaly (HP:0000262)1.83820433
109Absent forearm bone (HP:0003953)1.82889358
110Aplasia involving forearm bones (HP:0009822)1.82889358
111Spastic diplegia (HP:0001264)1.82797629
112Advanced eruption of teeth (HP:0006288)1.82673168
113Intestinal polyposis (HP:0200008)1.81953068
114Cerebral inclusion bodies (HP:0100314)1.81930406
115Abnormality of the gastric mucosa (HP:0004295)1.81619380
116Hyperacusis (HP:0010780)1.80982628
117Abnormal large intestine physiology (HP:0012700)1.80840643
118Metaphyseal cupping (HP:0003021)1.80084047
119Subacute progressive viral hepatitis (HP:0006572)1.79779151
120Short humerus (HP:0005792)1.79583831
121Abnormality of the fingertips (HP:0001211)1.78964418
122Abnormality of the lower motor neuron (HP:0002366)1.78058196
123Ankle contracture (HP:0006466)1.77847882
124Abnormality of carpal bone ossification (HP:0006257)1.77043736
125Syringomyelia (HP:0003396)1.76430768
126Spinal cord lesions (HP:0100561)1.76430768
127Fused cervical vertebrae (HP:0002949)1.75644232
128Macroorchidism (HP:0000053)1.74971731
129Thickened helices (HP:0000391)1.74819622
130Ovarian neoplasm (HP:0100615)1.74767022
131Urethral obstruction (HP:0000796)1.74517602
132Diastasis recti (HP:0001540)1.72966588
133Chromosomal breakage induced by crosslinking agents (HP:0003221)1.72488213
134Large earlobe (HP:0009748)1.72266476
135Cutis marmorata (HP:0000965)1.71734621
136Shoulder girdle muscle weakness (HP:0003547)1.71324209
137Germ cell neoplasia (HP:0100728)1.70539931
138Dysmetric saccades (HP:0000641)1.70385233
139Renal cell carcinoma (HP:0005584)1.70355297
140Supernumerary spleens (HP:0009799)1.70280770
141Abnormality of the peritoneum (HP:0002585)1.70142655
142Nephroblastoma (Wilms tumor) (HP:0002667)1.70083314
143Chromsome breakage (HP:0040012)1.69494587
144Shawl scrotum (HP:0000049)1.69413100
145Limited elbow extension (HP:0001377)1.68964109
146Cafe-au-lait spot (HP:0000957)1.68925071
147Small epiphyses (HP:0010585)1.68734098
148Pointed chin (HP:0000307)1.68689810
149Ectopic kidney (HP:0000086)1.68648231
150Partial duplication of thumb phalanx (HP:0009944)1.67769253
151Abnormal ossification of hand bones (HP:0005921)1.67659453
152Vertebral clefting (HP:0008428)1.67246180
153Squamous cell carcinoma (HP:0002860)1.67234169
154Ulnar bowing (HP:0003031)1.66850994
155Papillary thyroid carcinoma (HP:0002895)1.66633491
156Renovascular hypertension (HP:0100817)1.66078896
157Abnormality of the 1st metacarpal (HP:0010009)1.65877333
158Hypercortisolism (HP:0001578)1.65303475
159Trigonocephaly (HP:0000243)1.64990065
160Spinal cord compression (HP:0002176)1.64844382
161Abnormality of the distal phalanges of the toes (HP:0010182)1.64179120
162Sparse lateral eyebrow (HP:0005338)1.64160975
163Duplication of thumb phalanx (HP:0009942)1.63854052
164Broad face (HP:0000283)1.61924691
165Abnormal ventriculo-arterial connection (HP:0011563)1.60901539
166Transposition of the great arteries (HP:0001669)1.60901539
167Abnormal connection of the cardiac segments (HP:0011545)1.60901539
168Micronodular cirrhosis (HP:0001413)1.60825687
169Abnormal tarsal ossification (HP:0008369)1.60597328
170Hypercalcemia (HP:0003072)1.60133183
171Short nail (HP:0001799)1.59970377
172Transitional cell carcinoma of the bladder (HP:0006740)1.59839444
173Truncus arteriosus (HP:0001660)1.59754840
174Progressive hearing impairment (HP:0001730)1.59666317
175Cupped ribs (HP:0000887)1.59152206
176Distal upper limb amyotrophy (HP:0007149)1.58431056
177Upper limb amyotrophy (HP:0009129)1.58431056
178Aplasia of the phalanges of the hand (HP:0009802)1.58370173
179Aplasia involving bones of the extremities (HP:0009825)1.58370173
180Aplasia involving bones of the upper limbs (HP:0009823)1.58370173
181Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.58262167

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.88912664
2CDC74.08035426
3SMG13.54329561
4PKN23.03251163
5WEE12.96586247
6MAP3K102.79196700
7TRIB32.65562687
8EEF2K2.65479027
9PRPF4B2.56172311
10MAP3K92.47486176
11NEK22.34580551
12SIK12.33941370
13IRAK32.26606080
14SCYL21.87198931
15ALK1.80660992
16TTK1.76604298
17CDK71.75889682
18BRD41.74734400
19STK241.73411935
20CDK41.68565419
21LATS21.66716936
22NEK11.63942739
23STK101.63016741
24ARAF1.61934087
25LATS11.59558973
26RPS6KB21.59233847
27FGFR41.56189150
28MKNK11.52643237
29FLT31.51039995
30BUB11.39518523
31MAP3K131.38798184
32CDK61.38622776
33TSSK61.37592353
34MKNK21.36829732
35PNCK1.36768641
36MAP3K81.33690082
37PDGFRA1.32730786
38BRAF1.32074463
39PASK1.31687793
40MTOR1.31260445
41ICK1.31174160
42EPHA21.27840728
43PLK11.25097667
44EIF2AK11.23754794
45DYRK31.23318845
46CAMK1G1.22446515
47TGFBR11.20848716
48RPS6KA41.20536498
49SRPK11.19864099
50CHEK11.18780692
51ATR1.18376416
52TYRO31.15045176
53PAK41.09524316
54LRRK21.08375362
55BRSK21.06309695
56AURKB1.00912723
57ACVR1B1.00854737
58PRKD30.98512380
59CDK20.97533092
60STK30.95241148
61ATM0.91904020
62PTK60.91836746
63MELK0.90324899
64ERN10.89867621
65TAOK20.89785139
66CHEK20.89649684
67GRK60.89231275
68PIM10.89143081
69BMX0.89052759
70MOS0.88183483
71PLK30.86420505
72RIPK10.85896035
73TAF10.85749451
74TTN0.85308377
75PBK0.83434359
76BRSK10.76351365
77PAK20.76132581
78MST1R0.74555387
79FGFR10.73957066
80MAP3K20.70481815
81LMTK20.68632613
82NTRK10.67842625
83CSNK1E0.67514349
84JAK30.67397447
85KSR10.67366404
86STK40.66540823
87MAP3K50.64812195
88PTK20.64111298
89MAP2K30.63852537
90DMPK0.63412741
91AURKA0.63027068
92CDK10.62722613
93IRAK20.62618586
94MARK30.61715279
95MARK20.60097888
96FGFR30.59900657
97TAOK10.57985578
98NEK60.56143967
99MET0.55978496
100CSNK2A20.54716166
101PDGFRB0.54529141
102MAP2K20.54047217
103MAP4K10.53473438
104MAP3K10.50921518
105DDR20.50770385
106SIK30.49885183
107KSR20.49405945
108SGK30.49256330
109NME20.49046758
110CSNK1D0.48569306
111MAP3K30.48520950
112TESK20.48438167
113AKT20.48415477
114PDPK10.48298700
115PRKDC0.48232295
116TESK10.47851548
117ILK0.44511159
118ERBB40.43895536
119RPS6KA10.43191795
120CDK11A0.42519703
121MAPK140.42171320
122MAPK10.41949625
123PRKCI0.40928985
124PAK10.40135599
125YES10.40120843
126SIK20.39800530
127MAP3K110.39774310
128STK110.38347937
129CDK90.37996460
130EIF2AK30.36900490
131ZAP700.36801668
132DYRK1B0.34995139
133MAPK100.33982715
134CAMK1D0.33643139
135GSK3B0.33581892
136AKT10.33332842

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.42236932
2RNA transport_Homo sapiens_hsa030133.31774498
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.26228873
4Spliceosome_Homo sapiens_hsa030403.16361492
5Mismatch repair_Homo sapiens_hsa034303.01383698
6One carbon pool by folate_Homo sapiens_hsa006702.63612542
7Cell cycle_Homo sapiens_hsa041102.52210839
8mRNA surveillance pathway_Homo sapiens_hsa030152.48914100
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.29946233
10Ribosome_Homo sapiens_hsa030102.17183329
11Base excision repair_Homo sapiens_hsa034101.84348737
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.76011848
13Nucleotide excision repair_Homo sapiens_hsa034201.73541512
14RNA polymerase_Homo sapiens_hsa030201.65214321
15Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.53522768
16RNA degradation_Homo sapiens_hsa030181.52821192
17mTOR signaling pathway_Homo sapiens_hsa041501.48324149
18MicroRNAs in cancer_Homo sapiens_hsa052061.47563043
19Thyroid cancer_Homo sapiens_hsa052161.47193738
20p53 signaling pathway_Homo sapiens_hsa041151.44319296
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.39148867
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34114292
23Homologous recombination_Homo sapiens_hsa034401.33502285
24ErbB signaling pathway_Homo sapiens_hsa040121.33317625
25Hippo signaling pathway_Homo sapiens_hsa043901.31839481
26Adherens junction_Homo sapiens_hsa045201.29130230
27Colorectal cancer_Homo sapiens_hsa052101.28731699
28Chronic myeloid leukemia_Homo sapiens_hsa052201.28731595
29Small cell lung cancer_Homo sapiens_hsa052221.28281470
30Prion diseases_Homo sapiens_hsa050201.27300824
31Insulin signaling pathway_Homo sapiens_hsa049101.27216756
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.26584057
33Viral carcinogenesis_Homo sapiens_hsa052031.22993070
34Basal cell carcinoma_Homo sapiens_hsa052171.22929032
35TGF-beta signaling pathway_Homo sapiens_hsa043501.20745999
36Oocyte meiosis_Homo sapiens_hsa041141.19152792
37Herpes simplex infection_Homo sapiens_hsa051681.18791243
38Vibrio cholerae infection_Homo sapiens_hsa051101.17508177
39HTLV-I infection_Homo sapiens_hsa051661.14513363
40Epstein-Barr virus infection_Homo sapiens_hsa051691.12500712
41Other glycan degradation_Homo sapiens_hsa005111.12169072
42Antigen processing and presentation_Homo sapiens_hsa046121.11620020
43Basal transcription factors_Homo sapiens_hsa030221.09685787
44Bladder cancer_Homo sapiens_hsa052191.07068265
45Pyrimidine metabolism_Homo sapiens_hsa002401.05856041
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.03109965
47Proteoglycans in cancer_Homo sapiens_hsa052051.02671237
48Inositol phosphate metabolism_Homo sapiens_hsa005621.01525928
49Fanconi anemia pathway_Homo sapiens_hsa034601.00790947
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00736068
51Notch signaling pathway_Homo sapiens_hsa043300.99307947
52Non-homologous end-joining_Homo sapiens_hsa034500.99049744
53Acute myeloid leukemia_Homo sapiens_hsa052210.97757146
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96134917
55Lysine degradation_Homo sapiens_hsa003100.93825500
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93732908
57Folate biosynthesis_Homo sapiens_hsa007900.93601644
58Selenocompound metabolism_Homo sapiens_hsa004500.90496999
59Vitamin B6 metabolism_Homo sapiens_hsa007500.89164064
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87323016
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86092315
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82302915
63Endometrial cancer_Homo sapiens_hsa052130.81123748
64Systemic lupus erythematosus_Homo sapiens_hsa053220.80921277
65Wnt signaling pathway_Homo sapiens_hsa043100.80269187
66Viral myocarditis_Homo sapiens_hsa054160.80120195
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.79871447
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79096621
69Prostate cancer_Homo sapiens_hsa052150.79018448
70Non-small cell lung cancer_Homo sapiens_hsa052230.76903877
71VEGF signaling pathway_Homo sapiens_hsa043700.76790393
72Hedgehog signaling pathway_Homo sapiens_hsa043400.76235182
73Choline metabolism in cancer_Homo sapiens_hsa052310.75536454
74Biosynthesis of amino acids_Homo sapiens_hsa012300.74061788
75Renal cell carcinoma_Homo sapiens_hsa052110.74053320
76Pathways in cancer_Homo sapiens_hsa052000.72917601
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72871036
78HIF-1 signaling pathway_Homo sapiens_hsa040660.72821324
79Hepatitis B_Homo sapiens_hsa051610.72723453
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71073291
81Proteasome_Homo sapiens_hsa030500.71036039
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70845485
83Galactose metabolism_Homo sapiens_hsa000520.70321745
84Pancreatic cancer_Homo sapiens_hsa052120.69070219
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.69066070
86Shigellosis_Homo sapiens_hsa051310.68184493
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68153098
88Steroid biosynthesis_Homo sapiens_hsa001000.67367668
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66991218
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66357916
91Glioma_Homo sapiens_hsa052140.65188775
92Long-term potentiation_Homo sapiens_hsa047200.64095379
93Focal adhesion_Homo sapiens_hsa045100.64092874
94GnRH signaling pathway_Homo sapiens_hsa049120.63735745
95Apoptosis_Homo sapiens_hsa042100.62414270
96Melanogenesis_Homo sapiens_hsa049160.61693193
97N-Glycan biosynthesis_Homo sapiens_hsa005100.61458642
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.60795277
99B cell receptor signaling pathway_Homo sapiens_hsa046620.60724650
100Hepatitis C_Homo sapiens_hsa051600.60088800
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.59691306
102Endocytosis_Homo sapiens_hsa041440.58439306
1032-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57745748
104AMPK signaling pathway_Homo sapiens_hsa041520.57460118
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57141754
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56194678
107Carbon metabolism_Homo sapiens_hsa012000.56038449
108Legionellosis_Homo sapiens_hsa051340.55153831
109Amoebiasis_Homo sapiens_hsa051460.54819349
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.53617959
111Glucagon signaling pathway_Homo sapiens_hsa049220.53364702
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53241145
113Melanoma_Homo sapiens_hsa052180.53234679
114Gap junction_Homo sapiens_hsa045400.52804194
115FoxO signaling pathway_Homo sapiens_hsa040680.52088235
116Toxoplasmosis_Homo sapiens_hsa051450.51031779
117Tight junction_Homo sapiens_hsa045300.50834274
118Influenza A_Homo sapiens_hsa051640.50756180
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49367639
120Dorso-ventral axis formation_Homo sapiens_hsa043200.49148608
121T cell receptor signaling pathway_Homo sapiens_hsa046600.48813524
122Nitrogen metabolism_Homo sapiens_hsa009100.48506761
123Prolactin signaling pathway_Homo sapiens_hsa049170.48388450
124Insulin resistance_Homo sapiens_hsa049310.45430468
125Estrogen signaling pathway_Homo sapiens_hsa049150.45126644
126Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43739740
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43084349
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43027361
129Measles_Homo sapiens_hsa051620.42101325
130Platelet activation_Homo sapiens_hsa046110.41006351
131Pentose phosphate pathway_Homo sapiens_hsa000300.39447169
132Leishmaniasis_Homo sapiens_hsa051400.38449946

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