YPEL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)9.55548267
2axon ensheathment in central nervous system (GO:0032291)9.55548267
3fatty acid elongation (GO:0030497)6.97282523
4ensheathment of neurons (GO:0007272)6.23210628
5axon ensheathment (GO:0008366)6.23210628
6myelination (GO:0042552)6.18086968
7long-chain fatty acid biosynthetic process (GO:0042759)5.57226237
8negative regulation of neurotransmitter secretion (GO:0046929)5.13195194
9negative regulation of neurotransmitter transport (GO:0051589)4.46461590
10photoreceptor cell differentiation (GO:0046530)4.31166782
11eye photoreceptor cell differentiation (GO:0001754)4.31166782
12myelin maintenance (GO:0043217)4.27314151
13apical protein localization (GO:0045176)4.25194602
14response to redox state (GO:0051775)4.11618536
15glycerophospholipid catabolic process (GO:0046475)4.06091890
16asymmetric protein localization (GO:0008105)3.99298507
17peptidyl-tyrosine autophosphorylation (GO:0038083)3.96833373
18oligodendrocyte differentiation (GO:0048709)3.90432644
19creatine metabolic process (GO:0006600)3.85264551
20negative regulation of protein localization to cell surface (GO:2000009)3.75096603
21cholesterol biosynthetic process (GO:0006695)3.69711213
22presynaptic membrane organization (GO:0097090)3.68955013
23negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.68647707
24establishment of mitochondrion localization (GO:0051654)3.67182871
25astrocyte development (GO:0014002)3.63962207
26regulation of collateral sprouting (GO:0048670)3.61024635
27L-amino acid import (GO:0043092)3.60795603
28presynaptic membrane assembly (GO:0097105)3.59522964
29adhesion of symbiont to host cell (GO:0044650)3.45264089
30virion attachment to host cell (GO:0019062)3.45264089
31neurotransmitter catabolic process (GO:0042135)3.41553176
32magnesium ion transport (GO:0015693)3.38177540
33glycosylceramide metabolic process (GO:0006677)3.33131235
34regulation of rhodopsin mediated signaling pathway (GO:0022400)3.30633394
35long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.26608851
36rhodopsin mediated signaling pathway (GO:0016056)3.25739980
37substantia nigra development (GO:0021762)3.23515936
38myelination in peripheral nervous system (GO:0022011)3.21603368
39peripheral nervous system axon ensheathment (GO:0032292)3.21603368
40import into cell (GO:0098657)3.21302752
41positive regulation of Rap GTPase activity (GO:0032854)3.19797755
42sterol biosynthetic process (GO:0016126)3.18312136
43negative regulation of JUN kinase activity (GO:0043508)3.18025822
44adult walking behavior (GO:0007628)3.11557016
45positive regulation of action potential (GO:0045760)3.10975221
46cerebellar granule cell differentiation (GO:0021707)3.10006122
47neuronal action potential propagation (GO:0019227)3.03447234
48protein palmitoylation (GO:0018345)3.02349050
49transmission of nerve impulse (GO:0019226)3.01119383
50negative regulation of execution phase of apoptosis (GO:1900118)2.98757768
51amyloid precursor protein metabolic process (GO:0042982)2.98626171
52negative regulation of macroautophagy (GO:0016242)2.98049068
53positive regulation of oligodendrocyte differentiation (GO:0048714)2.97478396
54negative regulation of erythrocyte differentiation (GO:0045647)2.97099107
55response to methylmercury (GO:0051597)2.94941734
56long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.91588249
57response to lipoprotein particle (GO:0055094)2.90519531
58regulation of catecholamine metabolic process (GO:0042069)2.88541424
59regulation of dopamine metabolic process (GO:0042053)2.88541424
60regulation of Rap GTPase activity (GO:0032317)2.86096928
61fatty-acyl-CoA biosynthetic process (GO:0046949)2.85527557
62membrane tubulation (GO:0097320)2.84382915
63isoprenoid biosynthetic process (GO:0008299)2.75713145
64positive regulation of gamma-delta T cell activation (GO:0046645)2.74979196
65synaptic transmission, dopaminergic (GO:0001963)2.72891102
66negative regulation of axonogenesis (GO:0050771)2.71865075
67cerebral cortex radially oriented cell migration (GO:0021799)2.71492392
68negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.68154606
69negative regulation of cell killing (GO:0031342)2.68154606
70histone H2B ubiquitination (GO:0033523)2.67590134
71ear development (GO:0043583)2.67406411
72detection of light stimulus involved in sensory perception (GO:0050962)2.65159471
73detection of light stimulus involved in visual perception (GO:0050908)2.65159471
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.64854938
75neuron cell-cell adhesion (GO:0007158)2.63796661
76neutrophil activation involved in immune response (GO:0002283)2.62367665
77cellular response to ethanol (GO:0071361)2.61852600
78Golgi to plasma membrane protein transport (GO:0043001)2.61131209
79glial cell development (GO:0021782)2.59534094
80relaxation of cardiac muscle (GO:0055119)2.58931551
81peptidyl-cysteine modification (GO:0018198)2.58514121
82amino acid import (GO:0043090)2.57399294
83nucleotide transmembrane transport (GO:1901679)2.57305309
84negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.57118718
85regulation of gamma-delta T cell activation (GO:0046643)2.55318490
86GPI anchor metabolic process (GO:0006505)2.55227177
87regulation of voltage-gated calcium channel activity (GO:1901385)2.51724804
88GPI anchor biosynthetic process (GO:0006506)2.51603162
89neuron remodeling (GO:0016322)2.51423555
90negative regulation of inclusion body assembly (GO:0090084)2.50718339
91cellular response to epinephrine stimulus (GO:0071872)2.50453313
92regulation of gamma-delta T cell differentiation (GO:0045586)2.50336680
93adhesion of symbiont to host (GO:0044406)2.50281808
94phospholipid homeostasis (GO:0055091)2.49775477
95fatty-acyl-CoA metabolic process (GO:0035337)2.49709644
96peripheral nervous system development (GO:0007422)2.49468941
97neuronal ion channel clustering (GO:0045161)2.47837785
98labyrinthine layer development (GO:0060711)2.46664761
99macroautophagy (GO:0016236)2.46560316
100cellular extravasation (GO:0045123)2.45190462
101cyclic nucleotide catabolic process (GO:0009214)2.44896742
102organ growth (GO:0035265)2.44797043
103behavioral response to cocaine (GO:0048148)2.44070849
104mating behavior (GO:0007617)2.43104435
105germinal center formation (GO:0002467)2.42821018
106pyrimidine-containing compound transmembrane transport (GO:0072531)2.42685374
107positive regulation of receptor recycling (GO:0001921)2.40252193
108iron coordination entity transport (GO:1901678)2.39991676
109axon development (GO:0061564)2.39942544
110positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.39167937
111mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.39167937
112phosphatidylserine metabolic process (GO:0006658)2.38909774
113ER overload response (GO:0006983)2.37965517
114cardiac muscle hypertrophy (GO:0003300)2.36378308
115dopamine biosynthetic process (GO:0042416)2.35854005
116positive regulation of neurological system process (GO:0031646)2.35638401
117acyl-CoA biosynthetic process (GO:0071616)2.34639051
118thioester biosynthetic process (GO:0035384)2.34639051
119detection of other organism (GO:0098543)2.33639355
120regulation of relaxation of muscle (GO:1901077)2.31430926
121positive regulation of cellular amide metabolic process (GO:0034250)2.28661838
122negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.26576201
123negative regulation of T-helper cell differentiation (GO:0045623)2.26576201
124regulation of ARF protein signal transduction (GO:0032012)2.26307232
125positive regulation of chemokine secretion (GO:0090197)2.25344321
126regulation of T-helper 2 cell differentiation (GO:0045628)2.25094124
127striated muscle hypertrophy (GO:0014897)2.24754100
128negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.24154659
129response to epinephrine (GO:0071871)2.20722748
130regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.20471537
131endothelium development (GO:0003158)2.19888479
132myofibril assembly (GO:0030239)2.19765481
133macrophage activation (GO:0042116)2.19345216
134production of molecular mediator involved in inflammatory response (GO:0002532)2.19158376
135cardiac muscle adaptation (GO:0014887)2.17726805
136cardiac muscle hypertrophy in response to stress (GO:0014898)2.17726805
137muscle hypertrophy in response to stress (GO:0003299)2.17726805
138macrophage activation involved in immune response (GO:0002281)2.17030934
139negative regulation of protein activation cascade (GO:2000258)2.15123502
140response to laminar fluid shear stress (GO:0034616)2.15040012
141cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.15016024
142negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.14945884
143muscle hypertrophy (GO:0014896)2.11756761
144regulation of B cell receptor signaling pathway (GO:0050855)2.08558811
145detection of bacterium (GO:0016045)2.08307599
146positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.07775567
147negative regulation of complement activation (GO:0045916)2.07608421
148mannose metabolic process (GO:0006013)2.06667495
149histone H3-K9 demethylation (GO:0033169)2.05479447
150leukocyte migration involved in inflammatory response (GO:0002523)2.04793401
151regulation of germinal center formation (GO:0002634)2.03670490
152regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.03316373
153positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.01007671
154positive regulation of fibroblast migration (GO:0010763)2.00800406
155detection of molecule of bacterial origin (GO:0032490)1.99985246
156regulation of beta-amyloid formation (GO:1902003)1.99247682
157regulation of chemokine secretion (GO:0090196)1.99216691
158Golgi to endosome transport (GO:0006895)1.98754574
159negative regulation of glycoprotein biosynthetic process (GO:0010561)1.97979209
160establishment of endothelial barrier (GO:0061028)1.97496446
161neutrophil activation (GO:0042119)1.95992947
162relaxation of muscle (GO:0090075)1.95924524
163modulation by organism of defense response of other organism involved in symbiotic interaction (GO:01.95846801
164positive regulation by organism of defense response of other organism involved in symbiotic interact1.95846801
165modulation by symbiont of host immune response (GO:0052553)1.95846801
166positive regulation by symbiont of host defense response (GO:0052509)1.95846801
167modulation by symbiont of host defense response (GO:0052031)1.95846801
168modulation by organism of immune response of other organism involved in symbiotic interaction (GO:001.95846801
169retrograde transport, vesicle recycling within Golgi (GO:0000301)1.95824000
170cellular response to fluid shear stress (GO:0071498)1.95519704
171regulation of clathrin-mediated endocytosis (GO:2000369)1.94157116
172negative regulation of humoral immune response (GO:0002921)1.93963440
173detection of external biotic stimulus (GO:0098581)1.93937686
174angiogenesis involved in wound healing (GO:0060055)1.93901353
175actin-myosin filament sliding (GO:0033275)1.93070522
176muscle filament sliding (GO:0030049)1.93070522
177antigen processing and presentation of endogenous antigen (GO:0019883)1.93012532
178regulation of energy homeostasis (GO:2000505)1.91971882
179definitive hemopoiesis (GO:0060216)1.91765199
180phospholipid efflux (GO:0033700)1.91486927
181regulation of platelet aggregation (GO:0090330)1.91346207
182negative regulation of amyloid precursor protein catabolic process (GO:1902992)1.90209967
183regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)1.89677381
184actin filament polymerization (GO:0030041)1.89022323
185Rap protein signal transduction (GO:0032486)1.88938463
186growth hormone receptor signaling pathway (GO:0060396)1.88920968
187regulation of transforming growth factor beta1 production (GO:0032908)1.88818979
188protein targeting to Golgi (GO:0000042)1.88167415
189cellular response to thyroid hormone stimulus (GO:0097067)1.87752945
190phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)1.87244067
191positive regulation of tolerance induction (GO:0002645)1.86544188
192striated muscle adaptation (GO:0014888)1.86488919
193interleukin-6-mediated signaling pathway (GO:0070102)1.85952485
194regulation of calcineurin-NFAT signaling cascade (GO:0070884)1.83490267
195establishment of protein localization to Golgi (GO:0072600)1.83400111
196B cell receptor signaling pathway (GO:0050853)1.83024003
197positive regulation of calcium ion transmembrane transporter activity (GO:1901021)1.82162659
198antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.81910659
199negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)1.80933371

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.12499539
2GBX2_23144817_ChIP-Seq_PC3_Human3.12055347
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.88751337
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.58336583
5SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.41276263
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.39169860
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.37035671
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.32602947
9TAF15_26573619_Chip-Seq_HEK293_Human2.30165552
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15499679
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.09520096
12JARID2_20064375_ChIP-Seq_MESCs_Mouse1.97098589
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.96202341
14RUNX_20019798_ChIP-Seq_JUKART_Human1.89784507
15EZH2_27304074_Chip-Seq_ESCs_Mouse1.87239080
16MTF2_20144788_ChIP-Seq_MESCs_Mouse1.87118180
17OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85302414
18GATA2_21666600_ChIP-Seq_HMVEC_Human1.84902526
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83862718
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.83175720
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.82260818
22RNF2_18974828_ChIP-Seq_MESCs_Mouse1.82260818
23VDR_22108803_ChIP-Seq_LS180_Human1.80936505
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80871836
25* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79400573
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.78789521
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74328330
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.67250441
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.66144594
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65313576
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63952479
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.62033597
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.60190229
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59926463
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59391328
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.57919225
37SCL_19346495_ChIP-Seq_HPC-7_Human1.57896508
38* RARB_27405468_Chip-Seq_BRAIN_Mouse1.57505765
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55921824
40* LXR_22158963_ChIP-Seq_LIVER_Mouse1.55694676
41* ER_23166858_ChIP-Seq_MCF-7_Human1.55362867
42* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.54773571
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.54199856
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.53908799
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.52401146
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52339807
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52212304
48* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51893226
49P53_22127205_ChIP-Seq_FIBROBLAST_Human1.51304472
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.50304062
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49221695
52EZH2_22144423_ChIP-Seq_EOC_Human1.48775436
53DROSHA_22980978_ChIP-Seq_HELA_Human1.48135367
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48098095
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46043688
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.45808872
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.45439198
58PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43576975
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42263600
60* FOXO3_23340844_ChIP-Seq_DLD1_Human1.42002176
61STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.40151572
62* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37516071
63REST_21632747_ChIP-Seq_MESCs_Mouse1.37235187
64MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35423316
65STAT3_23295773_ChIP-Seq_U87_Human1.34677484
66FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.34126925
67GATA1_19941826_ChIP-Seq_K562_Human1.33711106
68NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.33067339
69STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.32897637
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32556095
71VDR_24787735_ChIP-Seq_THP-1_Human1.32086568
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27652928
73* FOXA2_19822575_ChIP-Seq_HepG2_Human1.27641862
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27254565
75RXR_22158963_ChIP-Seq_LIVER_Mouse1.26666745
76SPI1_23127762_ChIP-Seq_K562_Human1.26218816
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24742733
78AR_21572438_ChIP-Seq_LNCaP_Human1.24555684
79* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23922468
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22819961
81ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19210478
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19068740
83ESR1_21235772_ChIP-Seq_MCF-7_Human1.18766137
84RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18671080
85TBL1_22424771_ChIP-Seq_293T_Human1.18504868
86PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18399159
87GATA1_22025678_ChIP-Seq_K562_Human1.18222039
88* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17602598
89* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16319482
90EP300_21415370_ChIP-Seq_HL-1_Mouse1.15401970
91REST_18959480_ChIP-ChIP_MESCs_Mouse1.15284347
92PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14978823
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14863496
94* GATA2_19941826_ChIP-Seq_K562_Human1.13977011
95GATA1_19941827_ChIP-Seq_MEL_Mouse1.13935211
96FUS_26573619_Chip-Seq_HEK293_Human1.13866920
97HTT_18923047_ChIP-ChIP_STHdh_Human1.13806187
98P300_19829295_ChIP-Seq_ESCs_Human1.13612683
99TBX20_22080862_ChIP-Seq_HEART_Mouse1.12709499
100TBX20_22328084_ChIP-Seq_HEART_Mouse1.12709499
101FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11827729
102CBX2_27304074_Chip-Seq_ESCs_Mouse1.10746606
103* SMAD4_21799915_ChIP-Seq_A2780_Human1.09490240
104TCF7_22412390_ChIP-Seq_EML_Mouse1.09361343
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08490889
106* EOMES_21245162_ChIP-Seq_HESCs_Human1.07526234
107* LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06607431
108* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06511923
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05560142
110THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05337099
111* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05331806
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05183744
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05026852
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04792838
115GATA1_26923725_Chip-Seq_HPCs_Mouse1.04626693
116NANOG_18555785_Chip-Seq_ESCs_Mouse1.04257639
117LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03848481
118EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03448379
119* TCF4_23295773_ChIP-Seq_U87_Human1.02938209
120BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01399195
121PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01334760
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00745493
123NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00745493
124CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00321389
125* AHR_22903824_ChIP-Seq_MCF-7_Human1.00175554
126TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98442811
127TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97880573
128CMYC_18555785_Chip-Seq_ESCs_Mouse0.97568854
129SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96675000
130CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96567810
131* ARNT_22903824_ChIP-Seq_MCF-7_Human0.96476229
132* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.96333124
133GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95591550
134* SMAD3_21741376_ChIP-Seq_HESCs_Human0.95275726
135* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95240896
136* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94934300
137WT1_19549856_ChIP-ChIP_CCG9911_Human0.94391642
138PHF8_20622853_ChIP-Seq_HELA_Human0.93951789
139* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93935829
140* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.93463759
141* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93248921
142NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92836315
143ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.92829451
144* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92752928
145SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92728939
146ESR2_21235772_ChIP-Seq_MCF-7_Human0.92506248
147RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92347864
148* TAL1_26923725_Chip-Seq_HPCs_Mouse0.92334022
149TRIM28_21343339_ChIP-Seq_HEK293_Human0.91676488
150POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91537611
151RUNX2_22187159_ChIP-Seq_PCA_Human0.91483096
152RNF2_27304074_Chip-Seq_NSC_Mouse0.91425672
153GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91417385
154TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90956628
155SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90694285
156* SOX2_21211035_ChIP-Seq_LN229_Gbm0.90590047
157P300_18555785_Chip-Seq_ESCs_Mouse0.90123289
158PRDM14_20953172_ChIP-Seq_ESCs_Human0.87448016
159FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.87139448
160* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85732208
161SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85594554
162RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.84420291
163E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.84073628
164* VDR_24763502_ChIP-Seq_THP-1_Human0.83858025
165* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.83470084
166GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82846454
167KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.81664372
168NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80817715
169TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.80585111
170AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80408397
171GATA3_27048872_Chip-Seq_THYMUS_Human0.80383295
172EGR1_23403033_ChIP-Seq_LIVER_Mouse0.80228252
173STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.80194726
174LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.80088082
175TP63_23658742_ChIP-Seq_EP156T_Human0.79008593
176GF1_26923725_Chip-Seq_HPCs_Mouse0.78801871
177CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.78063766
178RUNX1_22412390_ChIP-Seq_EML_Mouse0.77404077
179TP53_16413492_ChIP-PET_HCT116_Human0.76933195
180MYB_26560356_Chip-Seq_TH2_Human0.76666483
181KDM2B_26808549_Chip-Seq_DND41_Human0.75865902
182BCAT_22108803_ChIP-Seq_LS180_Human0.74776957

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.57386132
2MP0003950_abnormal_plasma_membrane3.89778418
3MP0003880_abnormal_central_pattern3.73104843
4MP0004270_analgesia3.44791417
5MP0003724_increased_susceptibility_to3.32829698
6MP0004510_myositis3.04349004
7MP0005451_abnormal_body_composition2.98620433
8MP0004885_abnormal_endolymph2.86805028
9MP0003828_pulmonary_edema2.75569420
10MP0005551_abnormal_eye_electrophysiolog2.75239475
11MP0003690_abnormal_glial_cell2.68586214
12MP0003329_amyloid_beta_deposits2.52018188
13MP0001529_abnormal_vocalization2.51806846
14MP0002272_abnormal_nervous_system2.44427506
15MP0004859_abnormal_synaptic_plasticity2.44379289
16MP0001486_abnormal_startle_reflex2.40409589
17MP0003191_abnormal_cellular_cholesterol2.39175019
18MP0001905_abnormal_dopamine_level2.37417496
19MP0005464_abnormal_platelet_physiology2.26256110
20MP0003303_peritoneal_inflammation2.25060905
21MP0004742_abnormal_vestibular_system2.17994043
22MP0002229_neurodegeneration2.17625721
23MP0008260_abnormal_autophagy2.17225993
24MP0002064_seizures2.16856504
25MP0003300_gastrointestinal_ulcer2.16046718
26MP0003634_abnormal_glial_cell2.14448973
27MP0004130_abnormal_muscle_cell2.13852511
28MP0003136_yellow_coat_color2.13600957
29MP0001485_abnormal_pinna_reflex2.12358896
30MP0002009_preneoplasia2.11896076
31MP0004084_abnormal_cardiac_muscle2.09167548
32MP0008004_abnormal_stomach_pH2.08280820
33MP0009046_muscle_twitch2.05236693
34MP0002822_catalepsy2.02779185
35MP0010678_abnormal_skin_adnexa1.99973145
36MP0004484_altered_response_of1.93979553
37MP0003635_abnormal_synaptic_transmissio1.86232700
38MP0002734_abnormal_mechanical_nocicepti1.78319747
39MP0005423_abnormal_somatic_nervous1.77685617
40MP0003436_decreased_susceptibility_to1.75166049
41MP0004043_abnormal_pH_regulation1.75070758
42MP0005171_absent_coat_pigmentation1.72319435
43MP0000383_abnormal_hair_follicle1.72313804
44MP0000465_gastrointestinal_hemorrhage1.71500189
45MP0005670_abnormal_white_adipose1.70185367
46MP0009745_abnormal_behavioral_response1.68458172
47MP0004142_abnormal_muscle_tone1.66673892
48MP0005409_darkened_coat_color1.66600238
49MP0003172_abnormal_lysosome_physiology1.61795756
50MP0000778_abnormal_nervous_system1.61560464
51MP0003045_fibrosis1.60499960
52MP0005167_abnormal_blood-brain_barrier1.58733870
53MP0002138_abnormal_hepatobiliary_system1.57964377
54MP0006072_abnormal_retinal_apoptosis1.57443102
55MP0001661_extended_life_span1.53945463
56MP0003632_abnormal_nervous_system1.53907511
57MP0000462_abnormal_digestive_system1.51611282
58MP0005253_abnormal_eye_physiology1.51457347
59MP0003646_muscle_fatigue1.40396564
60MP0004924_abnormal_behavior1.40236429
61MP0005386_behavior/neurological_phenoty1.40236429
62MP0010329_abnormal_lipoprotein_level1.40026092
63MP0010368_abnormal_lymphatic_system1.39932061
64MP0002882_abnormal_neuron_morphology1.39667825
65MP0001440_abnormal_grooming_behavior1.37134429
66MP0002419_abnormal_innate_immunity1.37074370
67MP0005195_abnormal_posterior_eye1.36190442
68MP0002063_abnormal_learning/memory/cond1.34509094
69MP0002166_altered_tumor_susceptibility1.33863037
70MP0002572_abnormal_emotion/affect_behav1.33839154
71MP0002332_abnormal_exercise_endurance1.32693196
72MP0005666_abnormal_adipose_tissue1.32433084
73MP0004215_abnormal_myocardial_fiber1.31245684
74MP0004381_abnormal_hair_follicle1.28657231
75MP0000747_muscle_weakness1.27957899
76MP0002752_abnormal_somatic_nervous1.24838671
77MP0000955_abnormal_spinal_cord1.24295534
78MP0002972_abnormal_cardiac_muscle1.22930968
79MP0001835_abnormal_antigen_presentation1.22292694
80MP0002067_abnormal_sensory_capabilities1.21821029
81MP0005365_abnormal_bile_salt1.21509072
82MP0002998_abnormal_bone_remodeling1.21418074
83MP0001346_abnormal_lacrimal_gland1.20293883
84MP0002066_abnormal_motor_capabilities/c1.19765381
85MP0003763_abnormal_thymus_physiology1.19113888
86MP0002139_abnormal_hepatobiliary_system1.18998679
87MP0001986_abnormal_taste_sensitivity1.18127558
88MP0003879_abnormal_hair_cell1.17539822
89MP0003075_altered_response_to1.17269249
90MP0004145_abnormal_muscle_electrophysio1.16692613
91MP0002127_abnormal_cardiovascular_syste1.16284538
92MP0001963_abnormal_hearing_physiology1.15824452
93MP0001299_abnormal_eye_distance/1.15315133
94MP0005000_abnormal_immune_tolerance1.15154903
95MP0001533_abnormal_skeleton_physiology1.14404818
96MP0005410_abnormal_fertilization1.14189935
97MP0004087_abnormal_muscle_fiber1.13615981
98MP0002106_abnormal_muscle_physiology1.13034291
99MP0003183_abnormal_peptide_metabolism1.12470865
100MP0005535_abnormal_body_temperature1.12392857
101MP0005025_abnormal_response_to1.11771034
102MP0001502_abnormal_circadian_rhythm1.11615641
103MP0003718_maternal_effect1.11374775
104MP0002971_abnormal_brown_adipose1.11269295
105MP0003631_nervous_system_phenotype1.10871129
106MP0008569_lethality_at_weaning1.10392839
107MP0009780_abnormal_chondrocyte_physiolo1.09721145
108MP0001800_abnormal_humoral_immune1.09137610
109MP0006082_CNS_inflammation1.08874504
110MP0000647_abnormal_sebaceous_gland1.07655963
111MP0004036_abnormal_muscle_relaxation1.07124990
112MP0003938_abnormal_ear_development1.06975633
113MP0002090_abnormal_vision1.06752318
114MP0000604_amyloidosis1.06058080
115MP0005620_abnormal_muscle_contractility1.05651501
116MP0005166_decreased_susceptibility_to1.05104246
117MP0001970_abnormal_pain_threshold1.05055331
118MP0005387_immune_system_phenotype1.03848204
119MP0001790_abnormal_immune_system1.03848204
120MP0000751_myopathy1.03642859
121MP0010630_abnormal_cardiac_muscle1.02944292
122MP0003656_abnormal_erythrocyte_physiolo1.02918621
123MP0003279_aneurysm1.02851299
124MP0004947_skin_inflammation1.02103789
125MP0003011_delayed_dark_adaptation1.01292353
126MP0004147_increased_porphyrin_level1.00525424
127MP0004883_abnormal_blood_vessel1.00509810
128MP0002118_abnormal_lipid_homeostasis0.99530130
129MP0005085_abnormal_gallbladder_physiolo0.98806525
130MP0003091_abnormal_cell_migration0.98193853
131MP0010155_abnormal_intestine_physiology0.97621284
132MP0002723_abnormal_immune_serum0.96237698
133MP0005375_adipose_tissue_phenotype0.95611587
134MP0000749_muscle_degeneration0.94916909
135MP0002933_joint_inflammation0.94282258
136MP0002405_respiratory_system_inflammati0.93918860
137MP0001765_abnormal_ion_homeostasis0.93550275
138MP0001177_atelectasis0.93099588
139MP0000249_abnormal_blood_vessel0.92963735
140MP0005164_abnormal_response_to0.91965152
141MP0001879_abnormal_lymphatic_vessel0.90559762
142MP0005369_muscle_phenotype0.90156811
143MP0009115_abnormal_fat_cell0.90038028
144MP0003866_abnormal_defecation0.89966281
145MP0001544_abnormal_cardiovascular_syste0.89825198
146MP0005385_cardiovascular_system_phenoty0.89825198
147MP0000566_synostosis0.89523558
148MP0003868_abnormal_feces_composition0.89297273
149MP0003195_calcinosis0.89232615
150MP0003787_abnormal_imprinting0.88784115
151MP0001545_abnormal_hematopoietic_system0.88630261
152MP0005397_hematopoietic_system_phenotyp0.88630261
153MP0002420_abnormal_adaptive_immunity0.88452552
154MP0003633_abnormal_nervous_system0.88431066
155MP0002909_abnormal_adrenal_gland0.88415830
156MP0008775_abnormal_heart_ventricle0.88061826
157MP0004185_abnormal_adipocyte_glucose0.86649060
158MP0005058_abnormal_lysosome_morphology0.86142875
159MP0001819_abnormal_immune_cell0.85678489
160MP0003937_abnormal_limbs/digits/tail_de0.85598591
161MP0002452_abnormal_antigen_presenting0.84895752
162MP0000013_abnormal_adipose_tissue0.83775495
163MP0002733_abnormal_thermal_nociception0.83155376
164MP0001501_abnormal_sleep_pattern0.82996445
165MP0009840_abnormal_foam_cell0.80116177
166MP0002152_abnormal_brain_morphology0.77568201
167MP0005646_abnormal_pituitary_gland0.76155483
168MP0000026_abnormal_inner_ear0.74952419
169MP0004085_abnormal_heartbeat0.73825334
170MP0005391_vision/eye_phenotype0.71245512
171MP0000003_abnormal_adipose_tissue0.69226238
172MP0001851_eye_inflammation0.68293895
173MP0005408_hypopigmentation0.66620792
174MP0000579_abnormal_nail_morphology0.66189176
175MP0005623_abnormal_meninges_morphology0.65814124
176MP0003137_abnormal_impulse_conducting0.65578842
177MP0006138_congestive_heart_failure0.63523303
178MP0002184_abnormal_innervation0.60600794
179MP0001968_abnormal_touch/_nociception0.56557144
180MP0004272_abnormal_basement_membrane0.55791704
181MP0003806_abnormal_nucleotide_metabolis0.55672220
182MP0005330_cardiomyopathy0.55596028
183MP0002796_impaired_skin_barrier0.55462896
184MP0000762_abnormal_tongue_morphology0.55114127

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.92370225
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.92370225
3Neurofibrillary tangles (HP:0002185)5.24701282
4Sensory axonal neuropathy (HP:0003390)4.60495350
5Abnormality of the corticospinal tract (HP:0002492)4.47011064
6Parakeratosis (HP:0001036)4.28150286
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.09569713
8Cerebral hypomyelination (HP:0006808)4.09177680
9Peripheral hypomyelination (HP:0007182)3.89937509
10Onion bulb formation (HP:0003383)3.79120044
11Prolonged bleeding time (HP:0003010)3.71040503
12Cerebral inclusion bodies (HP:0100314)3.67926814
13Spastic gait (HP:0002064)3.48931403
14Spontaneous hematomas (HP:0007420)3.44534532
15Gingival bleeding (HP:0000225)3.39992521
16Insidious onset (HP:0003587)3.38533848
17Termporal pattern (HP:0011008)3.38533848
18Congenital stationary night blindness (HP:0007642)3.30164454
19Supranuclear gaze palsy (HP:0000605)3.29725347
20Eczematoid dermatitis (HP:0000976)3.26755109
21Intention tremor (HP:0002080)3.23787662
22Exercise-induced myalgia (HP:0003738)3.19787526
23Dysmetria (HP:0001310)3.10834220
24Myokymia (HP:0002411)3.09737159
25Segmental peripheral demyelination/remyelination (HP:0003481)3.05867102
26Spastic paraparesis (HP:0002313)3.04471543
27Difficulty running (HP:0009046)3.01431983
28Papilledema (HP:0001085)3.00109744
29Abnormal auditory evoked potentials (HP:0006958)2.99686796
30Congenital ichthyosiform erythroderma (HP:0007431)2.96194284
31Epistaxis (HP:0000421)2.95524846
32Akinesia (HP:0002304)2.95269059
33Muscle fiber inclusion bodies (HP:0100299)2.91632426
34Nemaline bodies (HP:0003798)2.87772714
35Asymmetric septal hypertrophy (HP:0001670)2.84289122
36Hematochezia (HP:0002573)2.83271707
37Bundle branch block (HP:0011710)2.81618864
38Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.80683004
39Alacrima (HP:0000522)2.74844595
40Abnormality of macrophages (HP:0004311)2.71088388
41Muscle fiber splitting (HP:0003555)2.68961904
42Recurrent gram-negative bacterial infections (HP:0005420)2.68883825
43Split foot (HP:0001839)2.68408833
44Thickened helices (HP:0000391)2.67027254
45Slow saccadic eye movements (HP:0000514)2.65035776
46Menorrhagia (HP:0000132)2.62104612
47Ankle clonus (HP:0011448)2.60757153
48CNS hypomyelination (HP:0003429)2.58506707
49Scanning speech (HP:0002168)2.53858713
50Ventricular fibrillation (HP:0001663)2.53697700
51Anteriorly placed anus (HP:0001545)2.52380404
52Amyloidosis (HP:0011034)2.46779811
53Testicular neoplasm (HP:0010788)2.46061419
54Stomatitis (HP:0010280)2.45846539
55Hyperlipoproteinemia (HP:0010980)2.45047225
56Sudden death (HP:0001699)2.43729304
57Pheochromocytoma (HP:0002666)2.38529626
58Abnormality of the common coagulation pathway (HP:0010990)2.37806702
59Purpura (HP:0000979)2.36910289
60Abnormality of the left ventricular outflow tract (HP:0011103)2.34792780
61Subaortic stenosis (HP:0001682)2.34792780
62Abnormality of macular pigmentation (HP:0008002)2.33578597
63Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.33281977
64Abolished electroretinogram (ERG) (HP:0000550)2.32532249
65Autoamputation (HP:0001218)2.32168077
66Recurrent abscess formation (HP:0002722)2.31341899
67Recurrent bacterial skin infections (HP:0005406)2.30708629
68Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.29579557
69Focal motor seizures (HP:0011153)2.28260408
70Poor speech (HP:0002465)2.24705419
71Bony spicule pigmentary retinopathy (HP:0007737)2.23565371
72Ventricular tachycardia (HP:0004756)2.23185036
73EMG: myopathic abnormalities (HP:0003458)2.22980195
74Episodic fever (HP:0001954)2.22730384
75Joint hemorrhage (HP:0005261)2.22670790
76Ventricular arrhythmia (HP:0004308)2.21309453
77Generalized myoclonic seizures (HP:0002123)2.20944937
78Decreased lacrimation (HP:0000633)2.18087597
79Paraparesis (HP:0002385)2.17656591
80Abnormal platelet volume (HP:0011876)2.16757350
81Dysostosis multiplex (HP:0000943)2.16163970
82Spastic tetraparesis (HP:0001285)2.15882122
83Cerebral hemorrhage (HP:0001342)2.14854646
84Papillary thyroid carcinoma (HP:0002895)2.11766491
85Increased CSF protein (HP:0002922)2.11045135
86Action tremor (HP:0002345)2.10863854
87Gastrointestinal infarctions (HP:0005244)2.10435014
88Urinary glycosaminoglycan excretion (HP:0003541)2.09929139
89Mucopolysacchariduria (HP:0008155)2.09929139
90Aplasia of the phalanges of the hand (HP:0009802)2.09846252
91Aplasia involving bones of the extremities (HP:0009825)2.09846252
92Aplasia involving bones of the upper limbs (HP:0009823)2.09846252
93Obstructive sleep apnea (HP:0002870)2.09636768
94Epileptic encephalopathy (HP:0200134)2.08229207
95Lower limb muscle weakness (HP:0007340)2.07146389
96Absent septum pellucidum (HP:0001331)2.06964783
97Increased circulating renin level (HP:0000848)2.06117312
98Abnormality of the calf musculature (HP:0001430)2.05098007
99Erythroderma (HP:0001019)2.04424346
100Centrally nucleated skeletal muscle fibers (HP:0003687)2.03691599
101Clumsiness (HP:0002312)2.03528961
102Retinal dysplasia (HP:0007973)2.03416026
103Distal lower limb muscle weakness (HP:0009053)2.02603591
104Increased serum pyruvate (HP:0003542)2.02509850
105Abnormality of glycolysis (HP:0004366)2.02509850
106Abnormality of polysaccharide metabolism (HP:0011012)2.02087200
107Abnormality of glycosaminoglycan metabolism (HP:0004371)2.02087200
108Abnormality of mucopolysaccharide metabolism (HP:0011020)2.02087200
109Neuroendocrine neoplasm (HP:0100634)2.02029105
110Increased mean platelet volume (HP:0011877)2.01924301
111Premature skin wrinkling (HP:0100678)2.00803461
112Right ventricular cardiomyopathy (HP:0011663)2.00704192
113Decreased central vision (HP:0007663)2.00423594
114Abnormality of skeletal muscle fiber size (HP:0012084)2.00081866
115Atonic seizures (HP:0010819)1.99316619
116Myositis (HP:0100614)1.99294567
117Central scotoma (HP:0000603)1.97402661
118Muscle hypertrophy of the lower extremities (HP:0008968)1.96460899
119Hyperkalemia (HP:0002153)1.95539207
120Increased variability in muscle fiber diameter (HP:0003557)1.95098697
121Pulmonary embolism (HP:0002204)1.94995526
122Cupped ear (HP:0000378)1.94379921
123Calf muscle hypertrophy (HP:0008981)1.93684145
124Gingivitis (HP:0000230)1.92580996
125Heart block (HP:0012722)1.92394614
126Type 1 muscle fiber predominance (HP:0003803)1.92125255
127Systemic lupus erythematosus (HP:0002725)1.90391540
128Clonus (HP:0002169)1.87707305
129Morphological abnormality of the pyramidal tract (HP:0002062)1.86998631
130Congenital sensorineural hearing impairment (HP:0008527)1.86967620
131Vaginal atresia (HP:0000148)1.86910371
132Coronal craniosynostosis (HP:0004440)1.86757013
133Insulin-resistant diabetes mellitus (HP:0000831)1.86585135
134Decreased motor nerve conduction velocity (HP:0003431)1.85954163
135Malnutrition (HP:0004395)1.85889375
136Petechiae (HP:0000967)1.85758402
137Leukodystrophy (HP:0002415)1.85041704
138Adrenal hypoplasia (HP:0000835)1.84849525
139Bowel incontinence (HP:0002607)1.84511164
140Prolonged neonatal jaundice (HP:0006579)1.83873623
141EMG: neuropathic changes (HP:0003445)1.83707756
142Dysmetric saccades (HP:0000641)1.83656005
143Chest pain (HP:0100749)1.83070801
144Hyperglycemia (HP:0003074)1.82807936
145Retrobulbar optic neuritis (HP:0100654)1.82557580
146Optic neuritis (HP:0100653)1.82557580
147Syncope (HP:0001279)1.82139531
148Visceral angiomatosis (HP:0100761)1.82132533
149Hypomagnesemia (HP:0002917)1.82061619
150Synostosis involving the elbow (HP:0003938)1.82006196
151Humeroradial synostosis (HP:0003041)1.82006196
152Orchitis (HP:0100796)1.81271083
153Morphological abnormality of the inner ear (HP:0011390)1.81052808
154Abnormality of the septum pellucidum (HP:0007375)1.80668652
155Abnormal large intestine physiology (HP:0012700)1.79691139
156Genital tract atresia (HP:0001827)1.79532371
157Dyschromatopsia (HP:0007641)1.79314584
158Distal sensory impairment (HP:0002936)1.78969899
159Hypercortisolism (HP:0001578)1.78296039
160Diminished movement (HP:0002374)1.78140291
161Dysdiadochokinesis (HP:0002075)1.78123337
162Abnormal rod and cone electroretinograms (HP:0008323)1.78115544
163Facial diplegia (HP:0001349)1.76921805
164Mitral stenosis (HP:0001718)1.76787039
165Hyporeflexia of lower limbs (HP:0002600)1.74798569
166Joint swelling (HP:0001386)1.72856726
167Deep venous thrombosis (HP:0002625)1.72517132
168Complement deficiency (HP:0004431)1.72511727
169Infantile muscular hypotonia (HP:0008947)1.71744440
170Elevated erythrocyte sedimentation rate (HP:0003565)1.71257572
171Abnormality of calcium-phosphate metabolism (HP:0100530)1.71167024
172Hypoplastic pelvis (HP:0008839)1.70856468
173Abnormal atrioventricular conduction (HP:0005150)1.70853738
174Spontaneous abortion (HP:0005268)1.70604400
175Vertigo (HP:0002321)1.70046802
176Metabolic alkalosis (HP:0200114)1.70023243
177Megalencephaly (HP:0001355)1.69625592
178Polycythemia (HP:0001901)1.69546271
179Hypoglycemic seizures (HP:0002173)1.68893368
180Postnatal microcephaly (HP:0005484)1.68200034
181Urinary bladder sphincter dysfunction (HP:0002839)1.68004416
182Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.67025108
183Gowers sign (HP:0003391)1.66583125
184Tetraparesis (HP:0002273)1.65600699
185Frequent falls (HP:0002359)1.65135671
186Foot dorsiflexor weakness (HP:0009027)1.65064284
187Broad-based gait (HP:0002136)1.64648141
188Choroideremia (HP:0001139)1.64587512
189Arterial thrombosis (HP:0004420)1.64584726
190Cone-rod dystrophy (HP:0000548)1.63979417
191Hypokalemic alkalosis (HP:0001949)1.63942904
192Striae distensae (HP:0001065)1.63899833
193Hemoptysis (HP:0002105)1.63037708
194Postural instability (HP:0002172)1.62948276
195Hemorrhage of the eye (HP:0011885)1.62762103

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.08193216
2OXSR14.42618731
3PRPF4B3.05917178
4BCR2.70867404
5WNK42.61156104
6RIPK42.60177240
7EPHB12.35699787
8PNCK2.32441528
9MET2.28859461
10CDK192.20535814
11EPHA42.18215068
12NEK62.17636379
13WNK12.11990999
14PKN12.07503325
15FGFR22.06161860
16PBK1.93016385
17CSNK1G31.90611798
18CSNK1A1L1.90126634
19FES1.86203375
20AKT31.81143471
21TNIK1.76066477
22FRK1.70514855
23TIE11.68740992
24MAPKAPK51.67227223
25BLK1.63403691
26PAK61.61583375
27SGK21.61335695
28MAP2K31.60090099
29CSNK1G11.56546965
30NTRK11.55964799
31CSNK1G21.55925767
32FGFR31.55008168
33PIK3CG1.54463596
34ARAF1.52659009
35TYK21.50438153
36NLK1.49491358
37TNK21.48846839
38MAPK121.48083429
39SGK31.45375389
40CASK1.36986483
41ZAP701.35825757
42SGK2231.34919540
43SGK4941.34919540
44CAMK2B1.34412083
45MAP3K31.34104161
46UHMK11.33498837
47CSK1.32686294
48DAPK21.31566601
49MAP3K71.29055729
50ICK1.27348248
51TRPM71.26585593
52JAK11.26486622
53MAP3K11.25321896
54RIPK11.24963345
55CAMK2D1.24109404
56FER1.22459653
57LIMK11.20457641
58IKBKE1.18938848
59ROCK21.12935362
60TTN1.12896068
61MAP4K11.09820431
62CAMKK21.09697047
63PAK31.07495260
64TEC1.04354319
65TAOK31.04118881
66MAP3K91.03342794
67PIK3CA1.02521802
68PRKAA20.99633521
69MAP3K140.98656603
70SYK0.97106191
71HCK0.97004468
72STK240.96848659
73BTK0.96596768
74ITK0.96259139
75FGR0.96123544
76MARK20.93459610
77MARK10.92849247
78IRAK10.92797086
79CDK50.92316354
80CAMK2G0.91379466
81GRK60.90912369
82JAK20.88385330
83TGFBR20.87871732
84PINK10.86912191
85KSR20.82586462
86CDK140.81694669
87TBK10.81600313
88PDPK10.80375038
89CAMK2A0.79398849
90RET0.78844812
91CLK10.78493511
92IRAK20.77726440
93FGFR40.77561898
94ERBB40.75918696
95CAMK40.75675635
96STK380.74702127
97GRK10.74121068
98TYRO30.74100767
99TESK20.73992465
100BUB10.73818370
101EPHA30.72606735
102PTK2B0.72308651
103INSRR0.71973649
104CAMK10.71911513
105CAMKK10.71753367
106JAK30.70883871
107HIPK20.70606600
108ACVR1B0.70569741
109IKBKB0.68045548
110IRAK40.67707501
111STK110.67297286
112PRKCE0.66475481
113CDK150.66275873
114TXK0.65411304
115MAP3K130.65265647
116BMPR1B0.64073318
117ERN10.63717348
118CDC42BPA0.63240158
119CSF1R0.62760906
120CDK180.62416589
121YES10.61719920
122MAPK150.61624228
123MYLK0.61417984
124PDGFRB0.60630515
125DYRK20.59658502
126LCK0.59385460
127PRKCQ0.58883399
128PRKCH0.58091658
129NUAK10.57566308
130MAP3K60.57364752
131BRAF0.57270051
132CDK11A0.56618278
133MAPK70.56435918
134CSNK1A10.54703209
135PRKD10.54072614
136PKN20.53610619
137OBSCN0.53031002
138MELK0.52338011
139CSNK1D0.52070157
140MAP2K10.51649489
141DMPK0.51500651
142MARK30.50196694
143KIT0.48383951
144LMTK20.48216577
145MAP3K20.46136674
146WNK30.45279294
147BMPR20.45014352
148PDK10.44547469
149CDK30.42503210
150MST40.41814586
151PHKG20.40562355
152PHKG10.40562355
153MAPK100.40500798
154DYRK1A0.38328248
155MAP2K20.38187918
156RPS6KA50.38155356
157FYN0.38006065
158MUSK0.37781735
159LATS10.36734266
160PRKG10.36668819
161PRKD30.35102813
162PRKACB0.35038189
163CSNK1E0.34042696
164NTRK20.32997226
165PDK20.32502382
166SGK10.30847686
167GRK50.30732340
168CAMK1G0.30156648
169GSK3A0.29976524
170PRKACA0.29823632
171NTRK30.29803573

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.31897346
2Vitamin B6 metabolism_Homo sapiens_hsa007504.25559112
3Fatty acid elongation_Homo sapiens_hsa000623.67414188
4Steroid biosynthesis_Homo sapiens_hsa001003.50573001
5Phototransduction_Homo sapiens_hsa047443.44281607
6Ether lipid metabolism_Homo sapiens_hsa005652.65606545
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.49975103
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.34989301
9Sphingolipid metabolism_Homo sapiens_hsa006001.81841853
10Protein export_Homo sapiens_hsa030601.79903053
11Sulfur metabolism_Homo sapiens_hsa009201.76380189
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.74832267
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.74689013
14GABAergic synapse_Homo sapiens_hsa047271.63437364
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.57752396
16Linoleic acid metabolism_Homo sapiens_hsa005911.56487545
17Butanoate metabolism_Homo sapiens_hsa006501.52973969
18Glycerophospholipid metabolism_Homo sapiens_hsa005641.51397050
19Regulation of autophagy_Homo sapiens_hsa041401.50566055
20Osteoclast differentiation_Homo sapiens_hsa043801.49160102
21Platelet activation_Homo sapiens_hsa046111.48734062
22Staphylococcus aureus infection_Homo sapiens_hsa051501.42001016
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38371851
24Axon guidance_Homo sapiens_hsa043601.37434775
25Complement and coagulation cascades_Homo sapiens_hsa046101.33722923
26Glutamatergic synapse_Homo sapiens_hsa047241.33200671
27Morphine addiction_Homo sapiens_hsa050321.31063706
28Serotonergic synapse_Homo sapiens_hsa047261.29678556
29Histidine metabolism_Homo sapiens_hsa003401.28629824
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.27264055
31Renal cell carcinoma_Homo sapiens_hsa052111.26679382
32B cell receptor signaling pathway_Homo sapiens_hsa046621.24564246
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.23587227
34Leishmaniasis_Homo sapiens_hsa051401.20926217
35Insulin resistance_Homo sapiens_hsa049311.19487463
36Synaptic vesicle cycle_Homo sapiens_hsa047211.18910990
37Cocaine addiction_Homo sapiens_hsa050301.17718394
38Oxidative phosphorylation_Homo sapiens_hsa001901.13289859
39Tight junction_Homo sapiens_hsa045301.12946290
40mTOR signaling pathway_Homo sapiens_hsa041501.10870252
41Arginine and proline metabolism_Homo sapiens_hsa003301.08093080
42GnRH signaling pathway_Homo sapiens_hsa049121.08072169
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.07252669
44Type II diabetes mellitus_Homo sapiens_hsa049301.06985650
45Collecting duct acid secretion_Homo sapiens_hsa049661.05707453
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.04069968
47Nicotine addiction_Homo sapiens_hsa050331.03251950
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99308073
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98994675
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98879727
51FoxO signaling pathway_Homo sapiens_hsa040680.98834375
52Folate biosynthesis_Homo sapiens_hsa007900.98735304
53Other glycan degradation_Homo sapiens_hsa005110.96549661
54T cell receptor signaling pathway_Homo sapiens_hsa046600.96273456
55Circadian entrainment_Homo sapiens_hsa047130.95986244
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95742750
57Long-term depression_Homo sapiens_hsa047300.95028712
58Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93290836
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92757532
60Vibrio cholerae infection_Homo sapiens_hsa051100.91637251
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.91595251
62Dopaminergic synapse_Homo sapiens_hsa047280.89772334
63Tuberculosis_Homo sapiens_hsa051520.89033233
64Dorso-ventral axis formation_Homo sapiens_hsa043200.88852726
65Acute myeloid leukemia_Homo sapiens_hsa052210.87899326
66Insulin signaling pathway_Homo sapiens_hsa049100.87511637
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87157351
68Chemokine signaling pathway_Homo sapiens_hsa040620.86308259
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86191793
70PPAR signaling pathway_Homo sapiens_hsa033200.84766573
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84635274
72Amoebiasis_Homo sapiens_hsa051460.83708001
73Vitamin digestion and absorption_Homo sapiens_hsa049770.83651599
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.82384916
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80896317
76Pancreatic secretion_Homo sapiens_hsa049720.80781040
77ErbB signaling pathway_Homo sapiens_hsa040120.80665433
78Cholinergic synapse_Homo sapiens_hsa047250.80106197
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.79986470
80Amphetamine addiction_Homo sapiens_hsa050310.79514542
81Endocytosis_Homo sapiens_hsa041440.78625776
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.77567514
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76355737
84Cardiac muscle contraction_Homo sapiens_hsa042600.75625683
85Circadian rhythm_Homo sapiens_hsa047100.75424709
86Ovarian steroidogenesis_Homo sapiens_hsa049130.75238415
87Alzheimers disease_Homo sapiens_hsa050100.74840903
88Nitrogen metabolism_Homo sapiens_hsa009100.74681372
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74187372
90Lysosome_Homo sapiens_hsa041420.74160351
91Malaria_Homo sapiens_hsa051440.74026442
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74020094
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73440405
94Salivary secretion_Homo sapiens_hsa049700.73310794
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73291892
96Toxoplasmosis_Homo sapiens_hsa051450.73220104
97Non-small cell lung cancer_Homo sapiens_hsa052230.73107948
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72989264
99Bile secretion_Homo sapiens_hsa049760.72905720
100Glucagon signaling pathway_Homo sapiens_hsa049220.71964742
101VEGF signaling pathway_Homo sapiens_hsa043700.70928141
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.70916337
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70521051
104Pertussis_Homo sapiens_hsa051330.70217952
105Parkinsons disease_Homo sapiens_hsa050120.69807830
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.69588597
107Endometrial cancer_Homo sapiens_hsa052130.69266179
108Olfactory transduction_Homo sapiens_hsa047400.68797015
109Hematopoietic cell lineage_Homo sapiens_hsa046400.68640120
110HIF-1 signaling pathway_Homo sapiens_hsa040660.68408335
111Ras signaling pathway_Homo sapiens_hsa040140.68279540
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.67280995
113AMPK signaling pathway_Homo sapiens_hsa041520.66159403
114TNF signaling pathway_Homo sapiens_hsa046680.65668293
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65489696
116Arachidonic acid metabolism_Homo sapiens_hsa005900.65090942
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64554515
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64433204
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64395253
120MAPK signaling pathway_Homo sapiens_hsa040100.64301787
121Prolactin signaling pathway_Homo sapiens_hsa049170.63859151
122Mineral absorption_Homo sapiens_hsa049780.63390661
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63352028
124Insulin secretion_Homo sapiens_hsa049110.61710209
125Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60638032
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.59357614
127Gastric acid secretion_Homo sapiens_hsa049710.58052877
128Glycerolipid metabolism_Homo sapiens_hsa005610.57834069
129Rap1 signaling pathway_Homo sapiens_hsa040150.56458251
130Legionellosis_Homo sapiens_hsa051340.55602586
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55382201
132Focal adhesion_Homo sapiens_hsa045100.54558362
133African trypanosomiasis_Homo sapiens_hsa051430.54521255
134Fatty acid metabolism_Homo sapiens_hsa012120.54303442
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54028917
136Primary bile acid biosynthesis_Homo sapiens_hsa001200.53702272
137Estrogen signaling pathway_Homo sapiens_hsa049150.52791451
138Long-term potentiation_Homo sapiens_hsa047200.52206759
139Glioma_Homo sapiens_hsa052140.51605974
140Inositol phosphate metabolism_Homo sapiens_hsa005620.51218578
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49964515
142Taste transduction_Homo sapiens_hsa047420.49339601
143Renin secretion_Homo sapiens_hsa049240.48279037
144Choline metabolism in cancer_Homo sapiens_hsa052310.47741063
145cAMP signaling pathway_Homo sapiens_hsa040240.47313615
146Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46694308
147Glutathione metabolism_Homo sapiens_hsa004800.46071825
148Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46019744
149Rheumatoid arthritis_Homo sapiens_hsa053230.44918017
150Retinol metabolism_Homo sapiens_hsa008300.43648934
151Gap junction_Homo sapiens_hsa045400.43450538
152Oxytocin signaling pathway_Homo sapiens_hsa049210.42879038
153Hedgehog signaling pathway_Homo sapiens_hsa043400.41450568
154Metabolic pathways_Homo sapiens_hsa011000.41401536
155RNA polymerase_Homo sapiens_hsa030200.40337251
156Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39275604
157Steroid hormone biosynthesis_Homo sapiens_hsa001400.39207029
158Basal transcription factors_Homo sapiens_hsa030220.35781236
159Propanoate metabolism_Homo sapiens_hsa006400.35044344
160Calcium signaling pathway_Homo sapiens_hsa040200.34738113
161Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33532547
162ABC transporters_Homo sapiens_hsa020100.31048860
163Dilated cardiomyopathy_Homo sapiens_hsa054140.30456254
164Peroxisome_Homo sapiens_hsa041460.28662658

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