YOD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. The protein encoded by this gene belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.78623530
2limb bud formation (GO:0060174)5.45792404
3positive regulation of gamma-delta T cell activation (GO:0046645)5.32033241
4hepatocyte apoptotic process (GO:0097284)5.13382226
5nuclear pore organization (GO:0006999)5.04213290
6negative regulation of dendrite morphogenesis (GO:0050774)4.81497358
7presynaptic membrane assembly (GO:0097105)4.71075404
8monoubiquitinated protein deubiquitination (GO:0035520)4.62928904
9microglial cell activation (GO:0001774)4.56580301
10phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.52699377
11regulation of B cell receptor signaling pathway (GO:0050855)4.49635648
12short-term memory (GO:0007614)4.43940614
13dosage compensation (GO:0007549)4.23686226
14histone H3-K36 demethylation (GO:0070544)4.19701179
15erythrocyte development (GO:0048821)4.17050259
16pore complex assembly (GO:0046931)4.15064622
17histone mRNA catabolic process (GO:0071044)4.08900878
18presynaptic membrane organization (GO:0097090)4.02244770
19positive regulation of granulocyte differentiation (GO:0030854)4.00662379
20regulation of gamma-delta T cell differentiation (GO:0045586)3.98334828
21positive regulation of cellular response to oxidative stress (GO:1900409)3.97597532
22positive regulation of response to oxidative stress (GO:1902884)3.97597532
23negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.83709975
24detection of molecule of bacterial origin (GO:0032490)3.81381960
25regulation of gamma-delta T cell activation (GO:0046643)3.79562543
26positive regulation of insulin receptor signaling pathway (GO:0046628)3.76673427
27mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.69166312
28positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.69166312
29adenosine metabolic process (GO:0046085)3.69131187
30histone H3-K4 trimethylation (GO:0080182)3.65539374
31regulation of RNA export from nucleus (GO:0046831)3.63457891
32positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.60237631
33iron ion import (GO:0097286)3.60081288
34definitive hemopoiesis (GO:0060216)3.59677832
35regulation of necroptotic process (GO:0060544)3.55952294
36cartilage condensation (GO:0001502)3.54644148
37cell aggregation (GO:0098743)3.54644148
38signal peptide processing (GO:0006465)3.52382711
39cullin deneddylation (GO:0010388)3.47921034
40negative regulation of homotypic cell-cell adhesion (GO:0034111)3.46436431
41cytoplasmic mRNA processing body assembly (GO:0033962)3.46116644
42myeloid cell development (GO:0061515)3.45679811
43negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.43564790
44protein deneddylation (GO:0000338)3.39930874
45negative regulation of dendrite development (GO:2000171)3.39853675
46histone H3-K9 demethylation (GO:0033169)3.39818500
47N-terminal protein amino acid acetylation (GO:0006474)3.39249662
48negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.38102721
49negative regulation of cell killing (GO:0031342)3.38102721
50nucleotide transmembrane transport (GO:1901679)3.36232231
51positive regulation of protein homodimerization activity (GO:0090073)3.35963800
52postsynaptic membrane organization (GO:0001941)3.35594851
53regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.34846934
54neurotransmitter-gated ion channel clustering (GO:0072578)3.34098155
55positive regulation by symbiont of host defense response (GO:0052509)3.31566190
56modulation by symbiont of host defense response (GO:0052031)3.31566190
57modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.31566190
58modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.31566190
59positive regulation by organism of defense response of other organism involved in symbiotic interact3.31566190
60modulation by symbiont of host immune response (GO:0052553)3.31566190
61viral protein processing (GO:0019082)3.31341293
62dentate gyrus development (GO:0021542)3.29058350
63negative regulation of glycogen biosynthetic process (GO:0045719)3.27618212
64macrophage activation (GO:0042116)3.25780547
65protein neddylation (GO:0045116)3.24601931
66positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.24069212
67peripheral nervous system neuron development (GO:0048935)3.21428774
68negative regulation of B cell proliferation (GO:0030889)3.21377152
69neutrophil mediated immunity (GO:0002446)3.21071385
70ovulation from ovarian follicle (GO:0001542)3.21029431
71ER overload response (GO:0006983)3.20843571
72regulation of male gonad development (GO:2000018)3.20685128
73positive T cell selection (GO:0043368)3.18002505
74negative regulation of mast cell activation (GO:0033004)3.17225795
75peptidyl-lysine trimethylation (GO:0018023)3.16823825
76regulation of nucleobase-containing compound transport (GO:0032239)3.14987499
77negative regulation of glycogen metabolic process (GO:0070874)3.13762149
78regulation of histone H3-K27 methylation (GO:0061085)3.12622229
79chondrocyte development (GO:0002063)3.10814692
80cell differentiation involved in metanephros development (GO:0072202)3.08624927
81megakaryocyte development (GO:0035855)3.06276466
82myeloid leukocyte mediated immunity (GO:0002444)3.05880307
83negative regulation of keratinocyte proliferation (GO:0010839)3.05868235
84keratinization (GO:0031424)3.05353997
85regulation of cell maturation (GO:1903429)3.03749670
86inositol phosphate catabolic process (GO:0071545)3.03042878
87detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.02302360
88intraciliary transport (GO:0042073)3.01842600
89positive regulation of mitochondrial fission (GO:0090141)3.01240942
90cellular response to ethanol (GO:0071361)3.00981978
91embryonic process involved in female pregnancy (GO:0060136)3.00665224
92positive regulation of receptor recycling (GO:0001921)2.99858081
93cellular extravasation (GO:0045123)2.99824883
94histone lysine demethylation (GO:0070076)2.99711616
95histone demethylation (GO:0016577)2.97841546
96oxygen transport (GO:0015671)2.97737964
97B cell receptor signaling pathway (GO:0050853)2.97191125
98regulation of beta-amyloid formation (GO:1902003)2.96618711
99negative regulation of T cell mediated immunity (GO:0002710)2.96481705
100negative regulation of erythrocyte differentiation (GO:0045647)2.96272872
101positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.96133454
102superoxide anion generation (GO:0042554)2.95168965
103cytochrome complex assembly (GO:0017004)2.93566211
104regulation of rhodopsin mediated signaling pathway (GO:0022400)2.93404626
105cellular response to epinephrine stimulus (GO:0071872)2.92068685
106respiratory chain complex IV assembly (GO:0008535)2.90400914
107positive regulation of B cell differentiation (GO:0045579)2.90218833
108negative T cell selection (GO:0043383)2.90212786
109eye photoreceptor cell differentiation (GO:0001754)2.89788431
110photoreceptor cell differentiation (GO:0046530)2.89788431
111endocardial cushion morphogenesis (GO:0003203)2.88797807
112negative regulation of neurotransmitter transport (GO:0051589)2.88639406
113histone-serine phosphorylation (GO:0035404)2.88553284
114detection of external biotic stimulus (GO:0098581)2.87798218
115positive regulation of male gonad development (GO:2000020)2.86100767
116negative regulation of DNA repair (GO:0045738)2.85423748
117protein complex biogenesis (GO:0070271)2.85243179
118macrophage activation involved in immune response (GO:0002281)2.84132772
119histamine secretion (GO:0001821)2.82631362
120appendage development (GO:0048736)2.82562923
121limb development (GO:0060173)2.82562923
122peptidyl-threonine phosphorylation (GO:0018107)2.82381773
123regulation of platelet aggregation (GO:0090330)2.81896040
124cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.81695929
125protein destabilization (GO:0031648)2.80525954
126negative regulation of myoblast differentiation (GO:0045662)2.80364641
127sympathetic nervous system development (GO:0048485)2.79997374
128negative regulation of norepinephrine secretion (GO:0010700)2.78572811
129negative thymic T cell selection (GO:0045060)2.78288627
130positive regulation of erythrocyte differentiation (GO:0045648)2.76670214
131negative regulation of necroptotic process (GO:0060546)2.75243269
132protoporphyrinogen IX biosynthetic process (GO:0006782)2.74936186
133regulation of erythrocyte differentiation (GO:0045646)2.74855333
134serotonin receptor signaling pathway (GO:0007210)2.74521904
135keratan sulfate catabolic process (GO:0042340)2.74472591
136regulation of inositol phosphate biosynthetic process (GO:0010919)2.73217287
137negative regulation of lymphocyte mediated immunity (GO:0002707)2.72439600
138histone H3-K4 methylation (GO:0051568)2.72287150
139rhodopsin mediated signaling pathway (GO:0016056)2.71584241
140mitotic sister chromatid cohesion (GO:0007064)2.70847156
141antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.70517763
142daunorubicin metabolic process (GO:0044597)2.69784844
143polyketide metabolic process (GO:0030638)2.69784844
144doxorubicin metabolic process (GO:0044598)2.69784844
145cellular response to BMP stimulus (GO:0071773)2.68309832
146response to BMP (GO:0071772)2.68309832
147sphingomyelin metabolic process (GO:0006684)2.67327988
148generation of neurons (GO:0048699)2.66086851
149response to methylmercury (GO:0051597)2.65938352
150peptidyl-threonine modification (GO:0018210)2.65530734
151mannosylation (GO:0097502)2.65206165
152negative regulation of complement activation (GO:0045916)2.64536108
153negative regulation of immunoglobulin mediated immune response (GO:0002890)2.63098315
154negative regulation of B cell mediated immunity (GO:0002713)2.63098315
155cellular response to gamma radiation (GO:0071480)2.62642226
156negative regulation of peptidyl-lysine acetylation (GO:2000757)2.62439950
157histone phosphorylation (GO:0016572)2.61877999
158protein demethylation (GO:0006482)2.61451446
159protein dealkylation (GO:0008214)2.61451446
160negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.60951653
161regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.59066312
162purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.58965569
163response to gravity (GO:0009629)2.58300012
164startle response (GO:0001964)2.58030226
165nonmotile primary cilium assembly (GO:0035058)2.57976498
166estrogen biosynthetic process (GO:0006703)2.55187184
167regulation of penile erection (GO:0060405)2.53550175
168notochord development (GO:0030903)2.51049646
169DNA ligation (GO:0006266)2.50795299
170mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.50781913
171mitochondrial respiratory chain complex I assembly (GO:0032981)2.50781913
172NADH dehydrogenase complex assembly (GO:0010257)2.50781913
173facial nerve structural organization (GO:0021612)2.50771420
174negative regulation of systemic arterial blood pressure (GO:0003085)2.49896593
175mesenchymal cell differentiation involved in kidney development (GO:0072161)2.49890305
176mesenchymal cell differentiation involved in renal system development (GO:2001012)2.49890305
177deoxyribose phosphate biosynthetic process (GO:0046385)2.48734437
1782-deoxyribonucleotide biosynthetic process (GO:0009265)2.48734437
179cyclooxygenase pathway (GO:0019371)2.46827585
180purine ribonucleotide transport (GO:0015868)2.45915262
181detection of other organism (GO:0098543)2.45275528
182protein localization to cilium (GO:0061512)2.44328799
183sleep (GO:0030431)2.43858014
184protoporphyrinogen IX metabolic process (GO:0046501)2.43277624
185cilium assembly (GO:0042384)2.43105211
186neuron cell-cell adhesion (GO:0007158)2.41596171
187positive regulation of cellular amide metabolic process (GO:0034250)2.40524999
188positive regulation of steroid hormone secretion (GO:2000833)2.39849221
189kidney morphogenesis (GO:0060993)2.39770502
190negative regulation of synaptic transmission, GABAergic (GO:0032229)2.38969108
191centriole assembly (GO:0098534)2.38692485
192protein-cofactor linkage (GO:0018065)2.37844798
193detection of mechanical stimulus involved in sensory perception (GO:0050974)2.36756536
194deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.36359849
195microtubule polymerization or depolymerization (GO:0031109)2.35558308
196chondrocyte differentiation (GO:0002062)2.34730192
197negative regulation of chemokine production (GO:0032682)2.33463046

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.40418120
2GBX2_23144817_ChIP-Seq_PC3_Human3.90407146
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.14617974
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.06918326
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.93791146
6SCL_19346495_ChIP-Seq_HPC-7_Human2.93615924
7MYB_21317192_ChIP-Seq_ERMYB_Mouse2.84333147
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.81984185
9GATA1_19941826_ChIP-Seq_K562_Human2.80355088
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.78385495
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.73756645
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.72094840
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.71969837
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.70141579
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.68663968
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.65496974
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.58024011
18TAF15_26573619_Chip-Seq_HEK293_Human2.36112809
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.34052828
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.33552234
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.29826020
22GATA2_19941826_ChIP-Seq_K562_Human2.28531985
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28498926
24IRF8_22096565_ChIP-ChIP_GC-B_Human2.27756748
25MYB_26560356_Chip-Seq_TH2_Human2.26160211
26AR_21572438_ChIP-Seq_LNCaP_Human2.24720018
27P300_19829295_ChIP-Seq_ESCs_Human2.21177857
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19838974
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.19705470
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16705278
31RUNX_20019798_ChIP-Seq_JUKART_Human2.12309302
32SUZ12_27294783_Chip-Seq_NPCs_Mouse2.11953690
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.09133346
34MYB_26560356_Chip-Seq_TH1_Human2.07959531
35E2F4_17652178_ChIP-ChIP_JURKAT_Human2.05697376
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.04853022
37NFE2_27457419_Chip-Seq_LIVER_Mouse2.03931822
38* NANOG_18555785_Chip-Seq_ESCs_Mouse1.96773375
39* P53_22387025_ChIP-Seq_ESCs_Mouse1.92288258
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.90433692
41EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.89807459
42* STAT3_18555785_Chip-Seq_ESCs_Mouse1.88541997
43* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.85425083
44* E2F1_18555785_Chip-Seq_ESCs_Mouse1.83823084
45IRF8_27001747_Chip-Seq_BMDM_Mouse1.83438112
46* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.83142368
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.81889605
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.81103841
49EWS_26573619_Chip-Seq_HEK293_Human1.79741831
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.78688947
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.78204825
52RNF2_27304074_Chip-Seq_NSC_Mouse1.76297323
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.75649986
54* P300_18555785_Chip-Seq_ESCs_Mouse1.74948568
55* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.71298020
56* CMYC_18555785_Chip-Seq_ESCs_Mouse1.66089473
57* NMYC_18555785_Chip-Seq_ESCs_Mouse1.66065212
58SMAD4_21799915_ChIP-Seq_A2780_Human1.65351824
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64373009
60* SOX2_18555785_Chip-Seq_ESCs_Mouse1.64285766
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.63279987
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62185069
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.61416049
64VDR_22108803_ChIP-Seq_LS180_Human1.60948206
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60884322
66KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.60756643
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59727975
68FUS_26573619_Chip-Seq_HEK293_Human1.59388826
69ER_23166858_ChIP-Seq_MCF-7_Human1.58803034
70* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.56891932
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.56348781
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55915270
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54207833
74SALL4_18804426_ChIP-ChIP_XEN_Mouse1.54014060
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53816535
76* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.52458222
77* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.52330523
78EZH2_22144423_ChIP-Seq_EOC_Human1.52329851
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52159351
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52033810
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.51538309
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51191130
83SPI1_23547873_ChIP-Seq_NB4_Human1.49282990
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.49101373
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48699005
86EED_16625203_ChIP-ChIP_MESCs_Mouse1.48675057
87* OCT4_18555785_Chip-Seq_ESCs_Mouse1.48427487
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.47437718
89IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.47179036
90EZH2_27304074_Chip-Seq_ESCs_Mouse1.46903440
91SPI1_23127762_ChIP-Seq_K562_Human1.46330020
92IGF1R_20145208_ChIP-Seq_DFB_Human1.45041239
93* ZFX_18555785_Chip-Seq_ESCs_Mouse1.41518209
94* KLF4_18555785_Chip-Seq_ESCs_Mouse1.41004176
95IRF8_21731497_ChIP-ChIP_J774_Mouse1.40827105
96POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40476066
97TAL1_26923725_Chip-Seq_HPCs_Mouse1.40431761
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40262903
99TP53_16413492_ChIP-PET_HCT116_Human1.39839674
100* PU1_27457419_Chip-Seq_LIVER_Mouse1.39755692
101GATA3_27048872_Chip-Seq_THYMUS_Human1.38523181
102TFEB_21752829_ChIP-Seq_HELA_Human1.38422294
103MYC_22102868_ChIP-Seq_BL_Human1.38274995
104SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.37441004
105* PU_27001747_Chip-Seq_BMDM_Mouse1.36766869
106* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.36164279
107NCOR1_26117541_ChIP-Seq_K562_Human1.35822090
108MAF_26560356_Chip-Seq_TH1_Human1.34685803
109* CTCF_18555785_Chip-Seq_ESCs_Mouse1.33378181
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.33029004
111PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32615762
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32523681
113VDR_24787735_ChIP-Seq_THP-1_Human1.32298922
114* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31776211
115CRX_20693478_ChIP-Seq_RETINA_Mouse1.31479856
116GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31131398
117* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.30305852
118* CHD1_26751641_Chip-Seq_LNCaP_Human1.28797941
119FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.28619148
120TP53_18474530_ChIP-ChIP_U2OS_Human1.27798982
121PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.27297794
122ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27045584
123RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.26498061
124ELK1_19687146_ChIP-ChIP_HELA_Human1.26054345
125* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23012657
126* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23012657
127KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22639503
128JARID2_20064375_ChIP-Seq_MESCs_Mouse1.22139431
129PKCTHETA_26484144_Chip-Seq_BREAST_Human1.21946031
130MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19779242
131GATA1_22025678_ChIP-Seq_K562_Human1.19770948
132CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.18832138
133KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.18517258
134SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17931304
135GATA1_19941827_ChIP-Seq_MEL_Mouse1.17691182
136SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16184463
137RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15784264
138* TCF7_22412390_ChIP-Seq_EML_Mouse1.15724218
139SRF_21415370_ChIP-Seq_HL-1_Mouse1.15523643
140FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15268202
141TCF4_23295773_ChIP-Seq_U87_Human1.15244422
142SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14331650
143HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14310393
144MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13756653
145STAT3_23295773_ChIP-Seq_U87_Human1.13377447
146FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.13118771
147AR_25329375_ChIP-Seq_VCAP_Human1.12582450
148SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12276956
149VDR_24763502_ChIP-Seq_THP-1_Human1.11807346
150RUNX2_22187159_ChIP-Seq_PCA_Human1.11692542
151SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10711094
152* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.10649015
153TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08864401
154POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08864401
155NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08358806
156SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07466689
157TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07134566
158SALL4_22934838_ChIP-ChIP_CD34+_Human1.06528872
159CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06125168
160* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05851165
161NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05831841
162IRF1_19129219_ChIP-ChIP_H3396_Human1.04873309
163PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04523923
164WT1_19549856_ChIP-ChIP_CCG9911_Human1.03789038
165TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03785149
166GATA3_26560356_Chip-Seq_TH2_Human1.03501652
167GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02032498
168IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00513529
169STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99874081
170CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98725745
171GATA1_19941827_ChIP-Seq_MEL86_Mouse0.96511993
172E2F1_21310950_ChIP-Seq_MCF-7_Human0.96460377
173PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95611355
174GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95303130
175FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95180694
176FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.94897763
177PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94149865
178RUNX1_22412390_ChIP-Seq_EML_Mouse0.93143358
179ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93105187
180SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92000314
181* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88597912
182CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88537687
183* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88385775
184UTX_26944678_Chip-Seq_JUKART_Human0.87052536
185RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86972416
186SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85712140
187SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84386413
188CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.81619109
189KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.80727638
190CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.80569761

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.12088189
2MP0000569_abnormal_digit_pigmentation4.83369427
3MP0001188_hyperpigmentation3.99318354
4MP0009697_abnormal_copulation3.19578339
5MP0005646_abnormal_pituitary_gland3.00064402
6MP0003787_abnormal_imprinting2.96756814
7MP0003136_yellow_coat_color2.84294259
8MP0004147_increased_porphyrin_level2.76394749
9MP0001986_abnormal_taste_sensitivity2.66545758
10MP0003221_abnormal_cardiomyocyte_apopto2.63833153
11MP0005171_absent_coat_pigmentation2.63671254
12MP0000015_abnormal_ear_pigmentation2.59583223
13MP0000566_synostosis2.58403722
14MP0005451_abnormal_body_composition2.54444658
15MP0002876_abnormal_thyroid_physiology2.47852096
16MP0004134_abnormal_chest_morphology2.44183176
17MP0005409_darkened_coat_color2.39982300
18MP0003880_abnormal_central_pattern2.33682344
19MP0002166_altered_tumor_susceptibility2.29088656
20MP0002735_abnormal_chemical_nociception2.26914969
21MP0010234_abnormal_vibrissa_follicle2.23216847
22MP0006292_abnormal_olfactory_placode2.22007634
23MP0003763_abnormal_thymus_physiology2.20766639
24MP0004808_abnormal_hematopoietic_stem2.16085508
25MP0005083_abnormal_biliary_tract2.08730949
26MP0002396_abnormal_hematopoietic_system2.08558412
27MP0005645_abnormal_hypothalamus_physiol2.06253214
28MP0003656_abnormal_erythrocyte_physiolo2.05747404
29MP0000372_irregular_coat_pigmentation2.01891421
30MP0009250_abnormal_appendicular_skeleto2.00414933
31MP0003828_pulmonary_edema1.97055430
32MP0002933_joint_inflammation1.96217103
33MP0006276_abnormal_autonomic_nervous1.91249436
34MP0002282_abnormal_trachea_morphology1.82961429
35MP0002736_abnormal_nociception_after1.81179709
36MP0003303_peritoneal_inflammation1.72864183
37MP0003941_abnormal_skin_development1.72734962
38MP0001835_abnormal_antigen_presentation1.72125413
39MP0008877_abnormal_DNA_methylation1.71391741
40MP0002638_abnormal_pupillary_reflex1.68995347
41MP0001968_abnormal_touch/_nociception1.67518576
42MP0009780_abnormal_chondrocyte_physiolo1.65510278
43MP0002398_abnormal_bone_marrow1.64969796
44MP0010307_abnormal_tumor_latency1.63846572
45MP0002163_abnormal_gland_morphology1.63043877
46MP0001984_abnormal_olfaction1.60573496
47MP0002751_abnormal_autonomic_nervous1.58137233
48MP0010352_gastrointestinal_tract_polyps1.56080520
49MP0000703_abnormal_thymus_morphology1.52591442
50MP0002006_tumorigenesis1.52157125
51MP0009379_abnormal_foot_pigmentation1.51786652
52MP0005464_abnormal_platelet_physiology1.50168362
53MP0004883_abnormal_blood_vessel1.49769723
54MP0004947_skin_inflammation1.48072291
55MP0010094_abnormal_chromosome_stability1.47783350
56MP0003183_abnormal_peptide_metabolism1.47399705
57MP0005076_abnormal_cell_differentiation1.45430454
58MP0005503_abnormal_tendon_morphology1.45349142
59MP0002722_abnormal_immune_system1.44240934
60MP0002796_impaired_skin_barrier1.44000278
61MP0003724_increased_susceptibility_to1.43990652
62MP0001545_abnormal_hematopoietic_system1.42963073
63MP0005397_hematopoietic_system_phenotyp1.42963073
64MP0001800_abnormal_humoral_immune1.42276950
65MP0000689_abnormal_spleen_morphology1.42200634
66MP0004381_abnormal_hair_follicle1.41738769
67MP0003077_abnormal_cell_cycle1.41695801
68MP0001270_distended_abdomen1.41298742
69MP0002095_abnormal_skin_pigmentation1.39284834
70MP0000163_abnormal_cartilage_morphology1.36958911
71MP0003111_abnormal_nucleus_morphology1.36438066
72MP0004782_abnormal_surfactant_physiolog1.31182348
73MP0001905_abnormal_dopamine_level1.30530087
74MP0002734_abnormal_mechanical_nocicepti1.29525112
75MP0005075_abnormal_melanosome_morpholog1.29217606
76MP0000049_abnormal_middle_ear1.28381237
77MP0002332_abnormal_exercise_endurance1.27546477
78MP0003172_abnormal_lysosome_physiology1.26932583
79MP0001963_abnormal_hearing_physiology1.26253363
80MP0001177_atelectasis1.25029099
81MP0001919_abnormal_reproductive_system1.24881870
82MP0000685_abnormal_immune_system1.23948954
83MP0003300_gastrointestinal_ulcer1.22969038
84MP0004484_altered_response_of1.22854798
85MP0001529_abnormal_vocalization1.21638902
86MP0000631_abnormal_neuroendocrine_gland1.19924124
87MP0002132_abnormal_respiratory_system1.17895527
88MP0004142_abnormal_muscle_tone1.17597912
89MP0005187_abnormal_penis_morphology1.17015661
90MP0003453_abnormal_keratinocyte_physiol1.16390290
91MP0002420_abnormal_adaptive_immunity1.15977683
92MP0005379_endocrine/exocrine_gland_phen1.15462037
93MP0000762_abnormal_tongue_morphology1.14139989
94MP0000026_abnormal_inner_ear1.13844992
95MP0005501_abnormal_skin_physiology1.13533964
96MP0001819_abnormal_immune_cell1.13444309
97MP0008004_abnormal_stomach_pH1.13380334
98MP0000716_abnormal_immune_system1.13305538
99MP0005408_hypopigmentation1.13204377
100MP0002877_abnormal_melanocyte_morpholog1.12963073
101MP0002405_respiratory_system_inflammati1.12532889
102MP0005621_abnormal_cell_physiology1.12404303
103MP0002419_abnormal_innate_immunity1.11079221
104MP0001542_abnormal_bone_strength1.10904161
105MP0002429_abnormal_blood_cell1.09511759
106MP0005174_abnormal_tail_pigmentation1.08554215
107MP0002115_abnormal_skeleton_extremities1.08387278
108MP0004957_abnormal_blastocyst_morpholog1.08270622
109MP0005310_abnormal_salivary_gland1.08209019
110MP0003646_muscle_fatigue1.07328234
111MP0002019_abnormal_tumor_incidence1.07209479
112MP0010386_abnormal_urinary_bladder1.05982720
113MP0002723_abnormal_immune_serum1.05363307
114MP0003122_maternal_imprinting1.05219214
115MP0002009_preneoplasia1.05173577
116MP0003091_abnormal_cell_migration1.04769442
117MP0002452_abnormal_antigen_presenting1.04297647
118MP0001851_eye_inflammation1.02906831
119MP0004185_abnormal_adipocyte_glucose1.01809652
120MP0003786_premature_aging1.01650681
121MP0001764_abnormal_homeostasis1.00932989
122MP0008260_abnormal_autophagy0.97913012
123MP0002067_abnormal_sensory_capabilities0.96818522
124MP0000371_diluted_coat_color0.95402861
125MP0002938_white_spotting0.95190711
126MP0002109_abnormal_limb_morphology0.94869760
127MP0000350_abnormal_cell_proliferation0.93949921
128MP0003121_genomic_imprinting0.93783231
129MP0008058_abnormal_DNA_repair0.93679721
130MP0002086_abnormal_extraembryonic_tissu0.93616619
131MP0000778_abnormal_nervous_system0.93548301
132MP0005551_abnormal_eye_electrophysiolog0.92983405
133MP0005164_abnormal_response_to0.91552696
134MP0005000_abnormal_immune_tolerance0.90204828
135MP0008995_early_reproductive_senescence0.90106997
136MP0003755_abnormal_palate_morphology0.90029870
137MP0005384_cellular_phenotype0.89556473
138MP0004264_abnormal_extraembryonic_tissu0.89359673
139MP0002113_abnormal_skeleton_development0.89111514
140MP0005025_abnormal_response_to0.89057786
141MP0003984_embryonic_growth_retardation0.89046808
142MP0002272_abnormal_nervous_system0.88336635
143MP0002088_abnormal_embryonic_growth/wei0.87560052
144MP0003436_decreased_susceptibility_to0.86560400
145MP0002160_abnormal_reproductive_system0.86381420
146MP0002572_abnormal_emotion/affect_behav0.86342823
147MP0009745_abnormal_behavioral_response0.85500208
148MP0008789_abnormal_olfactory_epithelium0.85307814
149MP0000427_abnormal_hair_cycle0.85146769
150MP0001915_intracranial_hemorrhage0.85009400
151MP0005389_reproductive_system_phenotype0.83985888
152MP0001502_abnormal_circadian_rhythm0.83308863
153MP0004742_abnormal_vestibular_system0.83073914
154MP0000858_altered_metastatic_potential0.81643701
155MP0000681_abnormal_thyroid_gland0.80666261
156MP0009046_muscle_twitch0.80661907
157MP0005380_embryogenesis_phenotype0.77980847
158MP0001672_abnormal_embryogenesis/_devel0.77980847
159MP0003011_delayed_dark_adaptation0.77742951
160MP0004270_analgesia0.76568720
161MP0005266_abnormal_metabolism0.75350557
162MP0002116_abnormal_craniofacial_bone0.75095407
163MP0005253_abnormal_eye_physiology0.74719982
164MP0001486_abnormal_startle_reflex0.74718927
165MP0001853_heart_inflammation0.74252527
166MP0002063_abnormal_learning/memory/cond0.72664637
167MP0000749_muscle_degeneration0.71623624
168MP0005390_skeleton_phenotype0.71204992
169MP0005376_homeostasis/metabolism_phenot0.71102115
170MP0003943_abnormal_hepatobiliary_system0.70675879
171MP0001191_abnormal_skin_condition0.70501448
172MP0001784_abnormal_fluid_regulation0.69405767
173MP0001697_abnormal_embryo_size0.69007296
174MP0001186_pigmentation_phenotype0.68860457
175MP0000313_abnormal_cell_death0.68682223
176MP0003191_abnormal_cellular_cholesterol0.68577439
177MP0010678_abnormal_skin_adnexa0.68377343
178MP0005508_abnormal_skeleton_morphology0.67860226
179MP0001664_abnormal_digestion0.66121423
180MP0008007_abnormal_cellular_replicative0.65738666
181MP0009333_abnormal_splenocyte_physiolog0.65440978
182MP0001970_abnormal_pain_threshold0.64963613

Predicted human phenotypes

RankGene SetZ-score
1Parkinsonism with favorable response to dopaminergic medication (HP:0002548)7.04414584
2Irregular epiphyses (HP:0010582)7.03626328
3Epiphyseal dysplasia (HP:0002656)6.30156652
4Vitreoretinal degeneration (HP:0000655)5.55010086
5Poikilocytosis (HP:0004447)4.94875868
6T lymphocytopenia (HP:0005403)4.45783997
7Recurrent bacterial skin infections (HP:0005406)4.22080159
8Flat capital femoral epiphysis (HP:0003370)4.21685592
9Slow saccadic eye movements (HP:0000514)4.14329993
10Abnormality of T cell number (HP:0011839)4.07878397
11Hypothermia (HP:0002045)4.03511897
12Small epiphyses (HP:0010585)3.95522012
13Abnormality of incisor morphology (HP:0011063)3.76961840
14Abnormal tarsal ossification (HP:0008369)3.73752006
15Cupped ribs (HP:0000887)3.62275255
16Genu varum (HP:0002970)3.62218433
17Arthropathy (HP:0003040)3.55160421
18Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.54133448
19Abnormality of femoral epiphyses (HP:0006499)3.54133448
20Papillary thyroid carcinoma (HP:0002895)3.52663595
21Eczematoid dermatitis (HP:0000976)3.48451155
22Acute myeloid leukemia (HP:0004808)3.47988320
23Delayed epiphyseal ossification (HP:0002663)3.46303525
24Hypoplastic ischia (HP:0003175)3.45018230
25Acanthocytosis (HP:0001927)3.38121534
26Abnormal hair whorl (HP:0010721)3.37623172
27Recurrent abscess formation (HP:0002722)3.32863978
28Abnormality of the epiphysis of the femoral head (HP:0010574)3.32540915
29Orthostatic hypotension (HP:0001278)3.31452395
30Subacute progressive viral hepatitis (HP:0006572)3.30134693
31Abnormality of the ischium (HP:0003174)3.29734536
32Metaphyseal dysplasia (HP:0100255)3.27822528
33Short femoral neck (HP:0100864)3.26734564
34Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.22909057
35Absent epiphyses (HP:0010577)3.22909057
36Abnormality of the vertebral endplates (HP:0005106)3.22018169
37Abnormality of the femoral head (HP:0003368)3.21925431
38Abnormality of the phalanges of the 2nd finger (HP:0009541)3.20997315
39True hermaphroditism (HP:0010459)3.05885377
40Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.04224483
41Hypochromic microcytic anemia (HP:0004840)3.03386664
42Postural instability (HP:0002172)3.01887218
43Microcytic anemia (HP:0001935)3.01202144
44Metaphyseal irregularity (HP:0003025)3.00611953
45Abnormality of the fingertips (HP:0001211)2.97885548
46Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.97821304
47Abnormal foot bone ossification (HP:0010675)2.93633678
48Recurrent viral infections (HP:0004429)2.91466898
49Recurrent fungal infections (HP:0002841)2.84873059
50Submucous cleft hard palate (HP:0000176)2.79545497
51Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.77984325
52Abnormality of the phalanges of the 5th finger (HP:0004213)2.77969894
53Gingival bleeding (HP:0000225)2.74006512
54Barrel-shaped chest (HP:0001552)2.73800660
55Gastrointestinal infarctions (HP:0005244)2.71512872
56Visual hallucinations (HP:0002367)2.68828716
57Spontaneous hematomas (HP:0007420)2.67512510
58Viral hepatitis (HP:0006562)2.67352140
59Irregular vertebral endplates (HP:0003301)2.64355635
60Recurrent skin infections (HP:0001581)2.63088403
61Abnormality of nail color (HP:0100643)2.61253824
62Abnormality of T cells (HP:0002843)2.59903117
63Ankyloglossia (HP:0010296)2.59690020
64Polycythemia (HP:0001901)2.53415867
65Fatigue (HP:0012378)2.49277451
66Neonatal short-limb short stature (HP:0008921)2.48089386
67Curly hair (HP:0002212)2.47738629
68Flattened epiphyses (HP:0003071)2.46578832
69Dysmetric saccades (HP:0000641)2.44394594
70Thyroid carcinoma (HP:0002890)2.44370762
71Fibular hypoplasia (HP:0003038)2.43175093
72Abnormal delayed hypersensitivity skin test (HP:0002963)2.38876179
73Flat acetabular roof (HP:0003180)2.38398651
74Long clavicles (HP:0000890)2.37957776
75Pancreatic fibrosis (HP:0100732)2.37607614
76Adrenal hypoplasia (HP:0000835)2.35803444
77Pustule (HP:0200039)2.35108212
78Deep philtrum (HP:0002002)2.35077922
79Gingivitis (HP:0000230)2.34912489
80Medial flaring of the eyebrow (HP:0010747)2.33106900
81Autoimmune hemolytic anemia (HP:0001890)2.31663613
82Conjunctival telangiectasia (HP:0000524)2.29244021
83Cholelithiasis (HP:0001081)2.26694443
84Mild short stature (HP:0003502)2.26351592
85Nephrogenic diabetes insipidus (HP:0009806)2.24786776
86Keratoconjunctivitis sicca (HP:0001097)2.24741902
87Febrile seizures (HP:0002373)2.24073079
88Increased IgE level (HP:0003212)2.23672104
89Arterial thrombosis (HP:0004420)2.22027922
90Resting tremor (HP:0002322)2.21135904
91Prolonged bleeding time (HP:0003010)2.20986437
92Leukocytosis (HP:0001974)2.20395343
93Sandal gap (HP:0001852)2.19542827
94Optic neuritis (HP:0100653)2.17079854
95Retrobulbar optic neuritis (HP:0100654)2.17079854
96Volvulus (HP:0002580)2.15595808
97Periodontitis (HP:0000704)2.14821024
98Abnormality of the heme biosynthetic pathway (HP:0010472)2.14443198
99Prominent nose (HP:0000448)2.14115929
100Recurrent cutaneous fungal infections (HP:0011370)2.14090269
101Chronic mucocutaneous candidiasis (HP:0002728)2.14090269
102Abnormality of the intervertebral disk (HP:0005108)2.13296121
103Urticaria (HP:0001025)2.13191932
104Aplasia/hypoplasia of the femur (HP:0005613)2.12598676
105Hypoplasia of the thymus (HP:0000778)2.12080931
106Abnormality of the vasculature of the conjunctiva (HP:0008054)2.10608978
107Osteoarthritis (HP:0002758)2.08656411
108Granulocytopenia (HP:0001913)2.08360560
109Congenital primary aphakia (HP:0007707)2.07986105
110Pelvic girdle muscle weakness (HP:0003749)2.05927327
111Epistaxis (HP:0000421)2.04690292
112Abnormality of the pubic bones (HP:0003172)2.03443815
113Dysautonomia (HP:0002459)2.02798062
114Erythema (HP:0010783)2.02710263
115Bladder neoplasm (HP:0009725)2.01083595
116Bladder carcinoma (HP:0002862)2.01083595
117Gait imbalance (HP:0002141)2.01044619
118Abnormal gallbladder morphology (HP:0012437)1.99072130
119Osteomalacia (HP:0002749)1.98929095
120Abnormality of oral frenula (HP:0000190)1.97888602
121Hypoplastic iliac wings (HP:0002866)1.96889055
122Enlarged epiphyses (HP:0010580)1.95987057
123Eosinophilia (HP:0001880)1.95898674
124Aplasia/Hypoplasia of the thymus (HP:0010515)1.95681187
125Keratoconjunctivitis (HP:0001096)1.95310703
126Epileptic encephalopathy (HP:0200134)1.95145036
127Hyperventilation (HP:0002883)1.92621929
128Neonatal hypoglycemia (HP:0001998)1.91418895
129Poor coordination (HP:0002370)1.90662181
130Median cleft lip (HP:0000161)1.89925196
131Patchy hypopigmentation of hair (HP:0011365)1.88757034
132Transitional cell carcinoma of the bladder (HP:0006740)1.88703502
133Ectropion (HP:0000656)1.88362102
134Orchitis (HP:0100796)1.88323582
135Absent frontal sinuses (HP:0002688)1.88169274
136Abnormality of saccadic eye movements (HP:0000570)1.86468387
137Cerebral inclusion bodies (HP:0100314)1.85699523
138Abnormal vertebral ossification (HP:0100569)1.85344983
139Hypoplastic ilia (HP:0000946)1.84941647
140Cholecystitis (HP:0001082)1.84472952
141Abnormal gallbladder physiology (HP:0012438)1.84472952
142Type I transferrin isoform profile (HP:0003642)1.84394859
143Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.83969653
144Tracheomalacia (HP:0002779)1.83016343
145Acute hepatic failure (HP:0006554)1.82578621
146Abnormality of carpal bone ossification (HP:0006257)1.81705512
14711 pairs of ribs (HP:0000878)1.81492096
148Neoplasm of the tracheobronchial system (HP:0100552)1.81408864
149Hypochromic anemia (HP:0001931)1.81199611
150Chronic hepatic failure (HP:0100626)1.80982349
151Stillbirth (HP:0003826)1.80775889
152Disproportionate short-trunk short stature (HP:0003521)1.80394799
153Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.80106850
154White forelock (HP:0002211)1.79851309
155Aplasia/Hypoplasia of the tibia (HP:0005772)1.79202659
156Osteomyelitis (HP:0002754)1.79064836
157Abnormality of chromosome stability (HP:0003220)1.78717255
158Somatic mutation (HP:0001428)1.78596316
159Reticulocytosis (HP:0001923)1.78343539
160Low anterior hairline (HP:0000294)1.77946551
161Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.76975141
162Lip pit (HP:0100267)1.76923464
163Autoamputation (HP:0001218)1.76909376
164Anhidrosis (HP:0000970)1.76567851
165Truncal obesity (HP:0001956)1.75733553
166Abnormality of the columella (HP:0009929)1.75675666
167Renal cortical cysts (HP:0000803)1.74942113
168Abnormality of the thymus (HP:0000777)1.74811991
169Peritonitis (HP:0002586)1.74588648
170Myositis (HP:0100614)1.74015910
171Genital tract atresia (HP:0001827)1.74002120
172Heterotopia (HP:0002282)1.73971733
173Bowel incontinence (HP:0002607)1.73376814
174Large earlobe (HP:0009748)1.72530217
175Abnormality of the nasal septum (HP:0000419)1.72324767
176Cystic hygroma (HP:0000476)1.71724126
177Astigmatism (HP:0000483)1.71389292
178Abnormality of the incisor (HP:0000676)1.71283285
179Increased mean platelet volume (HP:0011877)1.71138919
180Absent eyebrow (HP:0002223)1.70491257
181Abnormality of the frontal sinuses (HP:0002687)1.69572489
182Optic disc pallor (HP:0000543)1.69458185
183Abnormal platelet volume (HP:0011876)1.69308600
184Micromelia (HP:0002983)1.67642206
185Chromosomal breakage induced by crosslinking agents (HP:0003221)1.66644913
186Short tibia (HP:0005736)1.64809000
187Relative macrocephaly (HP:0004482)1.64285601
188Vaginal atresia (HP:0000148)1.63679844
189Hypoplastic pelvis (HP:0008839)1.63345574
190Protuberant abdomen (HP:0001538)1.63088244
191Short middle phalanx of the 5th finger (HP:0004220)1.62325654
192Amelogenesis imperfecta (HP:0000705)1.62323532
193Hypoplasia of the capital femoral epiphysis (HP:0003090)1.62117606
194Patent foramen ovale (HP:0001655)1.62107931
195Tubulointerstitial nephritis (HP:0001970)1.61423424
196Beaking of vertebral bodies (HP:0004568)1.60249310

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.29500215
2RIPK43.34357106
3MKNK23.32678225
4PRPF4B3.14316386
5SIK33.09653225
6AKT33.07761183
7GRK62.52251741
8MAP3K22.43192011
9MKNK12.38221849
10SGK22.37734059
11STK42.36346668
12MAP2K32.33396031
13FGR2.25261342
14STK242.24506786
15MAP3K32.18302433
16STK38L2.02651989
17ERBB32.02634219
18WNK12.02024098
19TNIK1.95747066
20BLK1.92127909
21CDK121.89538368
22BRD41.87624671
23NME11.85178188
24ZAK1.81281843
25MAP2K71.74071695
26NUAK11.73688450
27PTK2B1.71796062
28BMPR1B1.71615291
29PIM11.70763272
30MAP3K121.69565496
31SGK2231.68933538
32SGK4941.68933538
33PLK21.65236398
34STK161.63180774
35KSR21.62144368
36MST41.60134593
37KSR11.60117632
38BMPR21.53255017
39FGFR31.51565233
40YES11.51265967
41MAP3K141.42999992
42GRK51.38181625
43NEK61.35562143
44RAF11.35210187
45CAMK1D1.31976736
46CSK1.31840205
47BCR1.31114310
48SGK31.31068156
49SRPK11.29990436
50ADRBK21.29267429
51IRAK41.28158236
52JAK31.23363368
53MAP3K11.23055459
54SYK1.20016694
55DYRK31.19255119
56IRAK31.18359782
57MARK31.16947241
58CAMKK21.15157673
59MAPK131.12227883
60EIF2AK11.11902312
61BTK1.10700714
62TXK1.08427728
63EIF2AK21.07920028
64CDK81.05513172
65BRSK21.05259032
66CCNB11.04927145
67TAOK11.04897828
68TAOK31.04058991
69ERBB21.01100092
70MAP3K101.00789547
71FRK1.00300738
72ACVR1B0.98666023
73TLK10.98641319
74JAK20.92735697
75GRK70.92395706
76TYK20.90716441
77STK100.88288313
78DYRK1A0.86816719
79HCK0.86699740
80CDK60.86252852
81MAP3K60.86081169
82CAMK1G0.85807542
83EIF2AK30.85047108
84WEE10.84188052
85TAOK20.83962257
86JAK10.79199681
87RPS6KB10.73661882
88MARK20.72869719
89MAPK70.72853965
90FES0.72842675
91OXSR10.72535321
92CDK190.70737174
93MAP3K130.70729056
94MUSK0.70269557
95CDK30.69112829
96PLK30.68862140
97PIK3CA0.68665377
98INSRR0.67565941
99VRK10.65680041
100GRK10.64981662
101MYLK0.64044005
102TEC0.63709838
103TRPM70.63555918
104MAP3K50.62580781
105PRKG20.62340351
106PRKAA20.62204224
107LRRK20.60242712
108ITK0.57958436
109LYN0.57865959
110ZAP700.57676983
111MELK0.57004720
112PRKCE0.56056723
113PINK10.54039380
114IRAK10.53507820
115BRAF0.51868812
116BMX0.51613213
117ADRBK10.51452586
118STK380.48713573
119NEK90.48544275
120OBSCN0.48394265
121PRKCG0.47027209
122STK110.45743317
123RPS6KC10.44778515
124RPS6KL10.44778515
125MATK0.44595022
126RPS6KA60.44367389
127MAPK40.44250595
128EGFR0.44248195
129RPS6KA20.44199045
130CDK40.44082635
131PLK40.43675453
132CHUK0.41939044
133PDK20.41228851
134MAP4K10.40353530
135NTRK30.40351869
136CLK10.40032081
137PKN10.38667815
138RET0.38543184
139MAP3K70.38329531
140SGK10.38253627
141STK30.37611227
142RPS6KB20.37478264
143NLK0.37002908
144LCK0.36807220
145TNK20.36605730
146PIM20.35846186
147CAMK2A0.35661814
148IKBKE0.35584757
149IKBKB0.34621140
150PIK3CG0.33533585
151PRKG10.31560981
152CAMK40.30921283
153PRKCD0.30918292
154DYRK20.30516008
155CAMK2B0.29237786
156IRAK20.27594791
157MAPK120.26366332
158PRKACA0.25669609
159MAPK30.24590363
160BRSK10.24576230
161TSSK60.22416065
162WNK30.22289111

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.10685108
2Phototransduction_Homo sapiens_hsa047442.99388347
3SNARE interactions in vesicular transport_Homo sapiens_hsa041302.84866022
4Non-small cell lung cancer_Homo sapiens_hsa052232.77335096
5B cell receptor signaling pathway_Homo sapiens_hsa046622.40846265
6Sphingolipid metabolism_Homo sapiens_hsa006002.40501718
7Basal transcription factors_Homo sapiens_hsa030222.23192030
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.21486672
9Chronic myeloid leukemia_Homo sapiens_hsa052202.19408453
10Steroid biosynthesis_Homo sapiens_hsa001002.14945674
11Pancreatic cancer_Homo sapiens_hsa052122.08093862
12Oxidative phosphorylation_Homo sapiens_hsa001902.04230216
13Sulfur metabolism_Homo sapiens_hsa009202.03552451
14Acute myeloid leukemia_Homo sapiens_hsa052212.02989494
15NOD-like receptor signaling pathway_Homo sapiens_hsa046212.00418086
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00303954
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.99880917
18Olfactory transduction_Homo sapiens_hsa047401.97752961
19Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.93469148
20FoxO signaling pathway_Homo sapiens_hsa040681.88316136
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.87107699
22Arachidonic acid metabolism_Homo sapiens_hsa005901.87031441
23Non-homologous end-joining_Homo sapiens_hsa034501.82747371
24Fanconi anemia pathway_Homo sapiens_hsa034601.80312306
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.79809828
26Dorso-ventral axis formation_Homo sapiens_hsa043201.79032875
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.78349050
28Leishmaniasis_Homo sapiens_hsa051401.75243318
29Endometrial cancer_Homo sapiens_hsa052131.73775768
30Renal cell carcinoma_Homo sapiens_hsa052111.72332367
31T cell receptor signaling pathway_Homo sapiens_hsa046601.71138420
32Osteoclast differentiation_Homo sapiens_hsa043801.69486045
33Collecting duct acid secretion_Homo sapiens_hsa049661.65335117
34Fatty acid elongation_Homo sapiens_hsa000621.65311241
35Hepatitis B_Homo sapiens_hsa051611.65077956
36Inositol phosphate metabolism_Homo sapiens_hsa005621.59982779
37Prolactin signaling pathway_Homo sapiens_hsa049171.58689115
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.57543471
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56654096
40Thyroid cancer_Homo sapiens_hsa052161.55937711
41mTOR signaling pathway_Homo sapiens_hsa041501.52257805
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50918285
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.50648253
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50416172
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.48089620
46Proteasome_Homo sapiens_hsa030501.45870110
47Vibrio cholerae infection_Homo sapiens_hsa051101.41900650
48Prostate cancer_Homo sapiens_hsa052151.41749709
49Serotonergic synapse_Homo sapiens_hsa047261.38155326
50Toll-like receptor signaling pathway_Homo sapiens_hsa046201.36231617
51MicroRNAs in cancer_Homo sapiens_hsa052061.36228653
52Nicotine addiction_Homo sapiens_hsa050331.35070215
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.34856461
54Glioma_Homo sapiens_hsa052141.34564253
55Parkinsons disease_Homo sapiens_hsa050121.32746253
56RNA polymerase_Homo sapiens_hsa030201.30631238
57Influenza A_Homo sapiens_hsa051641.29664826
58Taste transduction_Homo sapiens_hsa047421.28502434
59p53 signaling pathway_Homo sapiens_hsa041151.28141661
60Homologous recombination_Homo sapiens_hsa034401.27364461
61Viral carcinogenesis_Homo sapiens_hsa052031.26675311
62Longevity regulating pathway - mammal_Homo sapiens_hsa042111.25935965
63Tuberculosis_Homo sapiens_hsa051521.25834789
64Phagosome_Homo sapiens_hsa041451.25604653
65Apoptosis_Homo sapiens_hsa042101.25380113
66Platelet activation_Homo sapiens_hsa046111.24262026
67ErbB signaling pathway_Homo sapiens_hsa040121.24134052
68VEGF signaling pathway_Homo sapiens_hsa043701.23588345
69Neurotrophin signaling pathway_Homo sapiens_hsa047221.22933940
70Rheumatoid arthritis_Homo sapiens_hsa053231.22902614
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22439300
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.22399351
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22090127
74Small cell lung cancer_Homo sapiens_hsa052221.19740737
75Hepatitis C_Homo sapiens_hsa051601.17677948
76Huntingtons disease_Homo sapiens_hsa050161.17284960
77Circadian rhythm_Homo sapiens_hsa047101.15498047
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13631730
79Colorectal cancer_Homo sapiens_hsa052101.11644205
80TNF signaling pathway_Homo sapiens_hsa046681.11404235
81Purine metabolism_Homo sapiens_hsa002301.09607688
82Regulation of autophagy_Homo sapiens_hsa041401.08608318
83Toxoplasmosis_Homo sapiens_hsa051451.08525148
84RNA degradation_Homo sapiens_hsa030181.08508955
85HIF-1 signaling pathway_Homo sapiens_hsa040661.08049175
86Base excision repair_Homo sapiens_hsa034101.07617702
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07260067
88Herpes simplex infection_Homo sapiens_hsa051681.04192313
89Chemokine signaling pathway_Homo sapiens_hsa040621.04126161
90Synaptic vesicle cycle_Homo sapiens_hsa047211.02385019
91Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01182629
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00810520
93mRNA surveillance pathway_Homo sapiens_hsa030150.99982536
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99297035
95Nucleotide excision repair_Homo sapiens_hsa034200.97840468
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97156381
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.97106081
98Alzheimers disease_Homo sapiens_hsa050100.96508282
99Choline metabolism in cancer_Homo sapiens_hsa052310.93855928
100Morphine addiction_Homo sapiens_hsa050320.92006690
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91933824
102Ether lipid metabolism_Homo sapiens_hsa005650.91338537
103Type II diabetes mellitus_Homo sapiens_hsa049300.90087590
104Hematopoietic cell lineage_Homo sapiens_hsa046400.89862126
105Autoimmune thyroid disease_Homo sapiens_hsa053200.88598359
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.88101168
107Long-term potentiation_Homo sapiens_hsa047200.86922760
108Protein digestion and absorption_Homo sapiens_hsa049740.86588858
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.86084821
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.84394258
111Circadian entrainment_Homo sapiens_hsa047130.83658913
112Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82732706
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80192577
114GnRH signaling pathway_Homo sapiens_hsa049120.75056011
115Pyrimidine metabolism_Homo sapiens_hsa002400.74517896
116ECM-receptor interaction_Homo sapiens_hsa045120.73680423
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.73625342
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72662145
119Malaria_Homo sapiens_hsa051440.72632608
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71214370
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71073115
122HTLV-I infection_Homo sapiens_hsa051660.70621186
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70277414
124Adherens junction_Homo sapiens_hsa045200.70214826
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69781514
126Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69172203
127AMPK signaling pathway_Homo sapiens_hsa041520.68282215
128Insulin resistance_Homo sapiens_hsa049310.67694035
129Vitamin digestion and absorption_Homo sapiens_hsa049770.67205234
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66554054
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66403591
132Primary immunodeficiency_Homo sapiens_hsa053400.64784743
133Epstein-Barr virus infection_Homo sapiens_hsa051690.63909447
134Bladder cancer_Homo sapiens_hsa052190.62414038
135Cell cycle_Homo sapiens_hsa041100.60019752
136Metabolic pathways_Homo sapiens_hsa011000.59960730
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59479953
138Retinol metabolism_Homo sapiens_hsa008300.59191282
139Insulin signaling pathway_Homo sapiens_hsa049100.57966748
140Allograft rejection_Homo sapiens_hsa053300.55946139
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55734207
142Intestinal immune network for IgA production_Homo sapiens_hsa046720.55241055
143MAPK signaling pathway_Homo sapiens_hsa040100.55103527
144Notch signaling pathway_Homo sapiens_hsa043300.54418347
145Proteoglycans in cancer_Homo sapiens_hsa052050.54224615
146Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53600027
147Ovarian steroidogenesis_Homo sapiens_hsa049130.53462902
148Calcium signaling pathway_Homo sapiens_hsa040200.53295115
149Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53084414
150Melanoma_Homo sapiens_hsa052180.52899183
151Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52613116
152Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52179569
153Linoleic acid metabolism_Homo sapiens_hsa005910.51513162
154RNA transport_Homo sapiens_hsa030130.50482545
155Basal cell carcinoma_Homo sapiens_hsa052170.48974558
156Lysine degradation_Homo sapiens_hsa003100.48867219
157Peroxisome_Homo sapiens_hsa041460.48714832
158Central carbon metabolism in cancer_Homo sapiens_hsa052300.47680769
159Pathways in cancer_Homo sapiens_hsa052000.46524138
160Phospholipase D signaling pathway_Homo sapiens_hsa040720.46283488
161Oocyte meiosis_Homo sapiens_hsa041140.44881958
162Estrogen signaling pathway_Homo sapiens_hsa049150.43920847
163Hedgehog signaling pathway_Homo sapiens_hsa043400.43105439
164Shigellosis_Homo sapiens_hsa051310.43078010
165Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42273344
166Legionellosis_Homo sapiens_hsa051340.41831431
167Mismatch repair_Homo sapiens_hsa034300.41510421
168Dopaminergic synapse_Homo sapiens_hsa047280.40788295
169Insulin secretion_Homo sapiens_hsa049110.39769503
170Long-term depression_Homo sapiens_hsa047300.38874242
171Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37263153
172Measles_Homo sapiens_hsa051620.36516971
173PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36135969
174Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34908881
175Amphetamine addiction_Homo sapiens_hsa050310.34004980
176Wnt signaling pathway_Homo sapiens_hsa043100.33909550
177Glutamatergic synapse_Homo sapiens_hsa047240.33744374
178RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32859263
179TGF-beta signaling pathway_Homo sapiens_hsa043500.32635617
180NF-kappa B signaling pathway_Homo sapiens_hsa040640.32588512
181Type I diabetes mellitus_Homo sapiens_hsa049400.31696512
182Other glycan degradation_Homo sapiens_hsa005110.30831129
183Alcoholism_Homo sapiens_hsa050340.30064900
184Chemical carcinogenesis_Homo sapiens_hsa052040.29414775
185N-Glycan biosynthesis_Homo sapiens_hsa005100.28805382

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