YKT6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product is one of the SNARE recognition molecules implicated in vesicular transport between secretory compartments. It is a membrane associated, isoprenylated protein that functions at the endoplasmic reticulum-Golgi transport step. This protein is highly conserved from yeast to human and can functionally complement the loss of the yeast homolog in the yeast secretory pathway. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1stress fiber assembly (GO:0043149)4.17279852
2cell adhesion mediated by integrin (GO:0033627)3.91056650
3pyrimidine nucleobase catabolic process (GO:0006208)3.85629631
4nucleobase catabolic process (GO:0046113)3.79088637
5hemidesmosome assembly (GO:0031581)3.78885857
6barbed-end actin filament capping (GO:0051016)3.75788099
7cell-substrate junction assembly (GO:0007044)3.70087801
8regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.69624595
9regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.66132985
10cell-substrate adherens junction assembly (GO:0007045)3.59119732
11focal adhesion assembly (GO:0048041)3.59119732
12negative regulation of fatty acid transport (GO:2000192)3.58520771
13cellular response to arsenic-containing substance (GO:0071243)3.56251219
14protein heterotrimerization (GO:0070208)3.52721085
15negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.38824282
16apoptotic cell clearance (GO:0043277)3.37001503
17axon extension involved in axon guidance (GO:0048846)3.33419475
18neuron projection extension involved in neuron projection guidance (GO:1902284)3.33419475
19skin morphogenesis (GO:0043589)3.32768708
20planar cell polarity pathway involved in neural tube closure (GO:0090179)3.32566507
21negative regulation of cardiac muscle tissue growth (GO:0055022)3.27324352
22negative regulation of heart growth (GO:0061117)3.27324352
23regulation of fatty acid beta-oxidation (GO:0031998)3.27105703
24Golgi transport vesicle coating (GO:0048200)3.21898292
25COPI coating of Golgi vesicle (GO:0048205)3.21898292
26maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.21477359
27regulation of glucose import in response to insulin stimulus (GO:2001273)3.20669345
28low-density lipoprotein particle clearance (GO:0034383)3.20646958
29regulation of mammary gland epithelial cell proliferation (GO:0033599)3.14468848
30cytoskeletal anchoring at plasma membrane (GO:0007016)3.13987710
31plasma membrane repair (GO:0001778)3.13460220
32negative regulation of cell size (GO:0045792)3.13182452
33semaphorin-plexin signaling pathway (GO:0071526)3.11053906
34protein localization to endosome (GO:0036010)3.08731421
35protein retention in ER lumen (GO:0006621)3.07452557
36positive regulation of fatty acid beta-oxidation (GO:0032000)3.05940102
37positive regulation of p38MAPK cascade (GO:1900745)3.02652636
38regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.02375679
39positive regulation of blood vessel endothelial cell migration (GO:0043536)3.01685111
40negative regulation of fibrinolysis (GO:0051918)2.99914445
41activation of Rac GTPase activity (GO:0032863)2.95244324
42protein maturation by protein folding (GO:0022417)2.94953698
43pinocytosis (GO:0006907)2.94153491
44apoptotic process involved in morphogenesis (GO:0060561)2.93491672
45activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.92536685
46epithelial cell differentiation involved in prostate gland development (GO:0060742)2.89501708
47vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.89176700
48layer formation in cerebral cortex (GO:0021819)2.89072716
49hippo signaling (GO:0035329)2.88580276
50collagen fibril organization (GO:0030199)2.88560637
51positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.85963563
52proline biosynthetic process (GO:0006561)2.85780555
53alpha-linolenic acid metabolic process (GO:0036109)2.84520164
54modulation by symbiont of host cellular process (GO:0044068)2.82844649
55endocytic recycling (GO:0032456)2.82632880
56positive regulation of glycogen biosynthetic process (GO:0045725)2.81425906
57dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.79686860
58positive regulation of nuclease activity (GO:0032075)2.78678181
59substrate-dependent cell migration (GO:0006929)2.76860744
60peptidyl-proline hydroxylation (GO:0019511)2.76748256
61regulation of cholesterol storage (GO:0010885)2.75272133
62response to laminar fluid shear stress (GO:0034616)2.73261576
63positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.73243871
64epithelial cell-cell adhesion (GO:0090136)2.72545991
65pentose-phosphate shunt (GO:0006098)2.72522813
66regulation of early endosome to late endosome transport (GO:2000641)2.72432976
67establishment of nucleus localization (GO:0040023)2.72407884
68cellular protein complex localization (GO:0034629)2.71846166
69regulation of p38MAPK cascade (GO:1900744)2.67605004
70regulation of NFAT protein import into nucleus (GO:0051532)2.66534954
71endodermal cell differentiation (GO:0035987)2.65289518
72macroautophagy (GO:0016236)2.64563058
73axon extension (GO:0048675)2.64135759
74collagen metabolic process (GO:0032963)2.64082431
75activation of MAPKKK activity (GO:0000185)2.63207334
76clathrin coat assembly (GO:0048268)2.63137484
77chondrocyte proliferation (GO:0035988)2.61605034
784-hydroxyproline metabolic process (GO:0019471)2.60929312
79desmosome organization (GO:0002934)2.60450551
80multicellular organismal macromolecule metabolic process (GO:0044259)2.59886059
81insulin-like growth factor receptor signaling pathway (GO:0048009)2.59673558
82embryo implantation (GO:0007566)2.58238733
83positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.58153560
84collagen catabolic process (GO:0030574)2.58149950
85endoplasmic reticulum unfolded protein response (GO:0030968)2.57069534
86positive regulation of receptor recycling (GO:0001921)2.54791708
87regulation of translational fidelity (GO:0006450)2.54583142
88regulation of extracellular matrix disassembly (GO:0010715)2.53935637
89adherens junction assembly (GO:0034333)2.52850020
90peptidyl-glutamic acid carboxylation (GO:0017187)2.50874115
91protein carboxylation (GO:0018214)2.50874115
92positive regulation of Cdc42 GTPase activity (GO:0043089)2.50629973
93endothelial cell chemotaxis (GO:0035767)2.50178810
94response to fluid shear stress (GO:0034405)2.49815986
95endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.49176512
96multicellular organismal catabolic process (GO:0044243)2.49038616
97multicellular organismal metabolic process (GO:0044236)2.48935584
98regulation of SMAD protein import into nucleus (GO:0060390)2.48218543
99vesicle coating (GO:0006901)2.48130496
100negative regulation of erythrocyte differentiation (GO:0045647)2.47878821
101embryonic process involved in female pregnancy (GO:0060136)2.47397828
102positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.46996227
103protein complex localization (GO:0031503)2.46563849
104actin filament bundle organization (GO:0061572)2.46384286
105actin filament bundle assembly (GO:0051017)2.46384286
106regulation of nuclease activity (GO:0032069)2.45975115
107cellular response to nutrient (GO:0031670)2.45934408
108membrane protein ectodomain proteolysis (GO:0006509)2.45785709
109germ cell migration (GO:0008354)2.45449198
110positive regulation of axon extension (GO:0045773)2.45332920
111cellular response to unfolded protein (GO:0034620)2.44737891
112extracellular matrix disassembly (GO:0022617)2.44532814
113regulation of hippo signaling (GO:0035330)2.44364576
114modulation by virus of host morphology or physiology (GO:0019048)2.43997328
115L-ascorbic acid metabolic process (GO:0019852)2.43963227
116negative regulation of lipid transport (GO:0032369)2.43812173
117glucose 6-phosphate metabolic process (GO:0051156)2.43616344
118ER-nucleus signaling pathway (GO:0006984)2.43016370
119basement membrane organization (GO:0071711)2.42637282
120cerebellar Purkinje cell layer development (GO:0021680)2.41430152
121mitotic chromosome condensation (GO:0007076)2.40724524
122maternal placenta development (GO:0001893)2.39400785
123cell migration involved in sprouting angiogenesis (GO:0002042)2.39296955
124hypotonic response (GO:0006971)2.37884942
125branching involved in mammary gland duct morphogenesis (GO:0060444)2.37695398
126neuron projection extension (GO:1990138)2.37530156
127cellular response to topologically incorrect protein (GO:0035967)2.37216255
128regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.36225239
129adhesion of symbiont to host (GO:0044406)2.36176903
130sequestering of extracellular ligand from receptor (GO:0035581)2.35918921
131regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.35579690
132positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.35579690
133protein hydroxylation (GO:0018126)2.34883116
134polarized epithelial cell differentiation (GO:0030859)2.34489003
135regulation of cholesterol homeostasis (GO:2000188)2.33999125
136cortical actin cytoskeleton organization (GO:0030866)2.33505164
137negative regulation of anoikis (GO:2000811)2.32982874
138hyaluronan catabolic process (GO:0030214)2.32569701
139positive regulation of fatty acid oxidation (GO:0046321)2.32512962
140regulation of nucleobase-containing compound transport (GO:0032239)2.32354821
141cellular response to fluid shear stress (GO:0071498)2.32015324
142protein localization to microtubule (GO:0035372)2.31727201
143midgut development (GO:0007494)2.31145836
144positive regulation of glycogen metabolic process (GO:0070875)2.30639212
145glucose catabolic process (GO:0006007)2.30558160
146lysine catabolic process (GO:0006554)2.30504659
147lysine metabolic process (GO:0006553)2.30504659
148modulation by virus of host process (GO:0019054)2.29916309
149negative regulation of protein localization to plasma membrane (GO:1903077)2.29114323
150regulation of fibrinolysis (GO:0051917)2.28963121
151retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.28742972
152cell junction maintenance (GO:0034331)2.28658022
1533-UTR-mediated mRNA stabilization (GO:0070935)2.28460828
154virion attachment to host cell (GO:0019062)2.28241553
155adhesion of symbiont to host cell (GO:0044650)2.28241553
156endothelial cell morphogenesis (GO:0001886)2.28217183
157NADPH regeneration (GO:0006740)2.27941065
158vascular endothelial growth factor signaling pathway (GO:0038084)2.27617082
159regulation of polysaccharide biosynthetic process (GO:0032885)2.25471218
160growth hormone secretion (GO:0030252)2.25407285

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.18893712
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.95699980
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.79485763
4CLOCK_20551151_ChIP-Seq_293T_Human3.66001873
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.44463018
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.21836237
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.13215474
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.48385516
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.28489196
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.20790547
11ZFP281_18757296_ChIP-ChIP_E14_Mouse2.20228951
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.13201761
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.12638724
14RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.11525765
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.08200267
16ZNF263_19887448_ChIP-Seq_K562_Human2.08131614
17ELK3_25401928_ChIP-Seq_HUVEC_Human2.05011266
18WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.03899466
19HIF1A_21447827_ChIP-Seq_MCF-7_Human2.02826460
20TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.01286214
21P300_27058665_Chip-Seq_ZR-75-30cells_Human1.99072152
22KDM2B_26808549_Chip-Seq_DND41_Human1.95173913
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.92284368
24* LXR_22292898_ChIP-Seq_THP-1_Human1.84610087
25LXR_22158963_ChIP-Seq_LIVER_Mouse1.84243634
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83135702
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.77233480
28KDM2B_26808549_Chip-Seq_K562_Human1.75250852
29KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.73596130
30TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.69232836
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.67939185
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.66066647
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65657913
34MYC_22102868_ChIP-Seq_BL_Human1.63105148
35EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.62812773
36ATF3_27146783_Chip-Seq_COLON_Human1.61639958
37RACK7_27058665_Chip-Seq_MCF-7_Human1.61248569
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.61064263
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58450496
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56495505
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.56104273
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54619146
43FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.53745395
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51341622
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.50840256
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.50803887
47CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49805315
48* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.48158030
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.47926815
50ZFP281_27345836_Chip-Seq_ESCs_Mouse1.47839136
51TCF7_22412390_ChIP-Seq_EML_Mouse1.45005868
52KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44439822
53NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.43149554
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.41935711
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41112981
56* TET1_21451524_ChIP-Seq_MESCs_Mouse1.41050442
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.40699224
58E2F7_22180533_ChIP-Seq_HELA_Human1.39972327
59UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39011822
60EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.38777648
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.38329837
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34859179
63MYC_18555785_ChIP-Seq_MESCs_Mouse1.34654852
64* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.34018885
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33842190
66ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.33371507
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.33163537
68DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.30563290
69SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30439778
70PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29894568
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.28740170
72FOXM1_23109430_ChIP-Seq_U2OS_Human1.27682448
73ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.27290472
74HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.26519664
75FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.24845177
76CREB1_26743006_Chip-Seq_LNCaP_Human1.24501905
77TBX20_22080862_ChIP-Seq_HEART_Mouse1.23009237
78TBX20_22328084_ChIP-Seq_HEART_Mouse1.23009237
79CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21643758
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21415833
81SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.21329093
82CJUN_26792858_Chip-Seq_BT549_Human1.21027542
83EP300_21415370_ChIP-Seq_HL-1_Mouse1.20117770
84MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19810800
85* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18615556
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18556796
87SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16976492
88SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16976492
89STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15445527
90RUNX1_27514584_Chip-Seq_MCF-7_Human1.15296830
91ERG_21242973_ChIP-ChIP_JURKAT_Human1.14620001
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13827381
93SA1_27219007_Chip-Seq_ERYTHROID_Human1.12568268
94ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11096147
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10319526
96UBF1/2_26484160_Chip-Seq_HMECs_Human1.09955253
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08690163
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08600637
99SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08576393
100RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07426399
101CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06869858
102SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06407034
103VDR_24763502_ChIP-Seq_THP-1_Human1.06271777
104* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05173680
105SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.04910457
106P68_20966046_ChIP-Seq_HELA_Human1.04894184
107XRN2_22483619_ChIP-Seq_HELA_Human1.04591112
108SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04024956
109* SMC4_20622854_ChIP-Seq_HELA_Human1.03737289
110BRD4_25478319_ChIP-Seq_HGPS_Human1.02772624
111TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02472964
112TP53_22127205_ChIP-Seq_IMR90_Human1.02376296
113SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02241684
114VDR_21846776_ChIP-Seq_THP-1_Human1.02019022
115* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01793970
116NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99718258
117* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.98360063
118OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97572628
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97036197
120NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96394514
121NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95757814
122TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.95587485
123RUNX1_22412390_ChIP-Seq_EML_Mouse0.95477973
124GATA6_25053715_ChIP-Seq_YYC3_Human0.95360184
125* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95330278
126ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95063531
127BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94433315
128* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94224645
129SOX2_20726797_ChIP-Seq_SW620_Human0.94189942
130CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93628217
131GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93201997
132SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93054651
133FOXA2_19822575_ChIP-Seq_HepG2_Human0.92047137
134CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91206051
135SOX9_24532713_ChIP-Seq_HFSC_Mouse0.89623368
136KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85965406
137TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.84405039
138DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84256404
139NCOR1_26117541_ChIP-Seq_K562_Human0.84196017

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.77508397
2MP0008438_abnormal_cutaneous_collagen4.43957232
3MP0006054_spinal_hemorrhage3.18874899
4MP0001958_emphysema2.93120270
5MP0005275_abnormal_skin_tensile2.78978744
6MP0005451_abnormal_body_composition2.53192536
7MP0005076_abnormal_cell_differentiation2.41564911
8MP0010234_abnormal_vibrissa_follicle2.35309388
9MP0010352_gastrointestinal_tract_polyps2.24912386
10MP0003566_abnormal_cell_adhesion2.24283144
11MP0001849_ear_inflammation2.18607819
12MP0005503_abnormal_tendon_morphology2.16909220
13MP0002139_abnormal_hepatobiliary_system2.10267247
14MP0010368_abnormal_lymphatic_system2.08107460
15MP0008260_abnormal_autophagy2.04757954
16MP0005623_abnormal_meninges_morphology1.98923955
17MP0003453_abnormal_keratinocyte_physiol1.94227007
18MP0009053_abnormal_anal_canal1.93894865
19MP0003279_aneurysm1.93128728
20MP0005360_urolithiasis1.90246320
21MP0004233_abnormal_muscle_weight1.86922030
22MP0003303_peritoneal_inflammation1.85575244
23MP0000537_abnormal_urethra_morphology1.84911688
24MP0004272_abnormal_basement_membrane1.83886816
25MP0005257_abnormal_intraocular_pressure1.82193915
26MP0003300_gastrointestinal_ulcer1.75254295
27MP0009780_abnormal_chondrocyte_physiolo1.74110673
28MP0005409_darkened_coat_color1.72820591
29MP0000604_amyloidosis1.61809311
30MP0002796_impaired_skin_barrier1.59237151
31MP0002896_abnormal_bone_mineralization1.55583338
32MP0000858_altered_metastatic_potential1.49167797
33MP0004185_abnormal_adipocyte_glucose1.48885352
34MP0004858_abnormal_nervous_system1.48449202
35MP0009840_abnormal_foam_cell1.45149811
36MP0003115_abnormal_respiratory_system1.43636343
37MP0003221_abnormal_cardiomyocyte_apopto1.42868352
38MP0002877_abnormal_melanocyte_morpholog1.42711273
39MP0005501_abnormal_skin_physiology1.42377796
40MP0001348_abnormal_lacrimal_gland1.40635695
41MP0010030_abnormal_orbit_morphology1.39840964
42MP0000678_abnormal_parathyroid_gland1.37744947
43MP0003091_abnormal_cell_migration1.35911502
44MP0000569_abnormal_digit_pigmentation1.35650917
45MP0003191_abnormal_cellular_cholesterol1.33171613
46MP0004130_abnormal_muscle_cell1.32490787
47MP0005023_abnormal_wound_healing1.30888524
48MP0003252_abnormal_bile_duct1.26594740
49MP0000733_abnormal_muscle_development1.26508433
50MP0003941_abnormal_skin_development1.25368248
51MP0000762_abnormal_tongue_morphology1.24549527
52MP0008961_abnormal_basal_metabolism1.21728144
53MP0005058_abnormal_lysosome_morphology1.19726087
54MP0002295_abnormal_pulmonary_circulatio1.19542441
55MP0001730_embryonic_growth_arrest1.16593679
56MP0000013_abnormal_adipose_tissue1.12508128
57MP0000767_abnormal_smooth_muscle1.12127902
58MP0010329_abnormal_lipoprotein_level1.12125849
59MP0003385_abnormal_body_wall1.11276593
60MP0001299_abnormal_eye_distance/1.09276643
61MP0001915_intracranial_hemorrhage1.07817764
62MP0005621_abnormal_cell_physiology1.07214161
63MP0001542_abnormal_bone_strength1.07105703
64MP0001216_abnormal_epidermal_layer1.06981282
65MP0005508_abnormal_skeleton_morphology1.06679083
66MP0001533_abnormal_skeleton_physiology1.05322562
67MP0000003_abnormal_adipose_tissue1.04670714
68MP0000747_muscle_weakness1.04467261
69MP0000579_abnormal_nail_morphology1.04192997
70MP0000750_abnormal_muscle_regeneration1.04037750
71MP0004883_abnormal_blood_vessel1.01114767
72MP0003172_abnormal_lysosome_physiology1.00507064
73MP0002089_abnormal_postnatal_growth/wei1.00338605
74MP0004087_abnormal_muscle_fiber1.00254993
75MP0003329_amyloid_beta_deposits0.99387317
76MP0000467_abnormal_esophagus_morphology0.98547461
77MP0000759_abnormal_skeletal_muscle0.98142977
78MP0005085_abnormal_gallbladder_physiolo0.98115070
79MP0004084_abnormal_cardiac_muscle0.97520300
80MP0000350_abnormal_cell_proliferation0.96618748
81MP0001879_abnormal_lymphatic_vessel0.95605006
82MP0009384_cardiac_valve_regurgitation0.94763684
83MP0001243_abnormal_dermal_layer0.94579470
84MP0005666_abnormal_adipose_tissue0.94365986
85MP0005187_abnormal_penis_morphology0.93994847
86MP0000428_abnormal_craniofacial_morphol0.93641387
87MP0003283_abnormal_digestive_organ0.93584831
88MP0003634_abnormal_glial_cell0.93393701
89MP0003448_altered_tumor_morphology0.89911651
90MP0002254_reproductive_system_inflammat0.89019804
91MP0004264_abnormal_extraembryonic_tissu0.88992338
92MP0002998_abnormal_bone_remodeling0.88514084
93MP0000751_myopathy0.87871398
94MP0003942_abnormal_urinary_system0.86297883
95MP0000534_abnormal_ureter_morphology0.85406444
96MP0010307_abnormal_tumor_latency0.84355672
97MP0004197_abnormal_fetal_growth/weight/0.83690152
98MP0005166_decreased_susceptibility_to0.83394234
99MP0003950_abnormal_plasma_membrane0.82923476
100MP0002128_abnormal_blood_circulation0.82307943
101MP0005390_skeleton_phenotype0.81998875
102MP0003075_altered_response_to0.81828932
103MP0010630_abnormal_cardiac_muscle0.81693868
104MP0002282_abnormal_trachea_morphology0.81258889
105MP0009278_abnormal_bone_marrow0.81063590
106MP0000490_abnormal_crypts_of0.81018274
107MP0002060_abnormal_skin_morphology0.80865019
108MP0002837_dystrophic_cardiac_calcinosis0.80744253
109MP0001853_heart_inflammation0.80612764
110MP0002080_prenatal_lethality0.79518097
111MP0005365_abnormal_bile_salt0.78993583
112MP0005248_abnormal_Harderian_gland0.78803749
113MP0000343_altered_response_to0.78051594
114MP0002086_abnormal_extraembryonic_tissu0.77595937
115MP0009672_abnormal_birth_weight0.77224613
116MP0003436_decreased_susceptibility_to0.76616719
117MP0000609_abnormal_liver_physiology0.76256206
118MP0001666_abnormal_nutrient_absorption0.75916393
119MP0003111_abnormal_nucleus_morphology0.75819833
120MP0000627_abnormal_mammary_gland0.75760529
121MP0004947_skin_inflammation0.75168120
122MP0005384_cellular_phenotype0.75128153
123MP0000462_abnormal_digestive_system0.74157877
124MP0005375_adipose_tissue_phenotype0.74132952
125MP0005164_abnormal_response_to0.74059587
126MP0003567_abnormal_fetal_cardiomyocyte0.73257759
127MP0001881_abnormal_mammary_gland0.72830413
128MP0005165_increased_susceptibility_to0.72693818
129MP0009931_abnormal_skin_appearance0.72585721
130MP0010771_integument_phenotype0.72481839
131MP0005385_cardiovascular_system_phenoty0.72421034
132MP0001544_abnormal_cardiovascular_syste0.72421034
133MP0004510_myositis0.72186526
134MP0004808_abnormal_hematopoietic_stem0.71621164
135MP0005197_abnormal_uvea_morphology0.71415561
136MP0005083_abnormal_biliary_tract0.69910466
137MP0004859_abnormal_synaptic_plasticity0.69384507
138MP0000377_abnormal_hair_follicle0.68860508
139MP0002115_abnormal_skeleton_extremities0.68595447
140MP0002925_abnormal_cardiovascular_devel0.68276628
141MP0003795_abnormal_bone_structure0.67133905
142MP0001672_abnormal_embryogenesis/_devel0.66266612
143MP0001614_abnormal_blood_vessel0.66099738
144MP0001177_atelectasis0.64960311
145MP0005332_abnormal_amino_acid0.64151269

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.33320684
2Protrusio acetabuli (HP:0003179)4.26885866
3Bladder diverticulum (HP:0000015)3.59005512
4Shallow orbits (HP:0000586)3.52282412
5Vertebral compression fractures (HP:0002953)3.46889879
6Hyperacusis (HP:0010780)3.41109950
7Cerebral aneurysm (HP:0004944)3.38727677
8Turricephaly (HP:0000262)3.05647587
9Renal duplication (HP:0000075)2.87886070
10Broad metatarsal (HP:0001783)2.86989658
11Fragile skin (HP:0001030)2.84408925
12Subacute progressive viral hepatitis (HP:0006572)2.84170874
13Distal lower limb amyotrophy (HP:0008944)2.82815769
14Renovascular hypertension (HP:0100817)2.78199290
15Peritonitis (HP:0002586)2.72221609
16Elfin facies (HP:0004428)2.72157733
17Aortic aneurysm (HP:0004942)2.69552709
18Bowel diverticulosis (HP:0005222)2.66677759
19Mitral valve prolapse (HP:0001634)2.64732597
20Ankle contracture (HP:0006466)2.64312044
21Papilledema (HP:0001085)2.58879404
22Dilatation of the ascending aorta (HP:0005111)2.55065146
23Aortic dissection (HP:0002647)2.54717347
24Thin bony cortex (HP:0002753)2.52833180
25Ulnar bowing (HP:0003031)2.52013153
26Deep venous thrombosis (HP:0002625)2.50324801
27Deviation of the hallux (HP:0010051)2.47808303
28Atrophic scars (HP:0001075)2.42598098
29Hallux valgus (HP:0001822)2.36316414
30Neurofibrillary tangles (HP:0002185)2.35138072
31Increased variability in muscle fiber diameter (HP:0003557)2.34940103
32Lymphangioma (HP:0100764)2.33970321
33Insomnia (HP:0100785)2.33379294
34Distal lower limb muscle weakness (HP:0009053)2.33010499
35Achilles tendon contracture (HP:0001771)2.32141435
36Overriding aorta (HP:0002623)2.32120475
37Abnormality of the Achilles tendon (HP:0005109)2.31644700
38Blue sclerae (HP:0000592)2.30447788
39Complement deficiency (HP:0004431)2.29444516
40Disproportionate tall stature (HP:0001519)2.29043150
41Osteolytic defects of the hand bones (HP:0009699)2.28416426
42Osteolytic defects of the phalanges of the hand (HP:0009771)2.28416426
43Short nail (HP:0001799)2.28251633
44Wormian bones (HP:0002645)2.26877350
45Aneurysm (HP:0002617)2.23096336
46Lower limb amyotrophy (HP:0007210)2.22835352
47Increased connective tissue (HP:0009025)2.22218320
48Systemic lupus erythematosus (HP:0002725)2.21915725
49Genu recurvatum (HP:0002816)2.21885248
50Abnormality of skeletal muscle fiber size (HP:0012084)2.19856128
51Long palpebral fissure (HP:0000637)2.19350495
52Hand muscle atrophy (HP:0009130)2.18146535
53Back pain (HP:0003418)2.17293901
54Distal upper limb amyotrophy (HP:0007149)2.17272860
55Upper limb amyotrophy (HP:0009129)2.17272860
56Hyperparathyroidism (HP:0000843)2.16177091
57Trismus (HP:0000211)2.16101294
58Broad face (HP:0000283)2.14325790
59Centrally nucleated skeletal muscle fibers (HP:0003687)2.14115467
60Elbow flexion contracture (HP:0002987)2.13880795
61Enlarged penis (HP:0000040)2.13659937
62Abnormal cartilage morphology (HP:0002763)2.12839098
63Abnormality of complement system (HP:0005339)2.12543205
64Long toe (HP:0010511)2.09852147
65Hydroxyprolinuria (HP:0003080)2.09547457
66Abnormality of proline metabolism (HP:0010907)2.09547457
67Increased cerebral lipofuscin (HP:0011813)2.09366415
68Flat cornea (HP:0007720)2.04534996
69Flat acetabular roof (HP:0003180)2.03919000
70Xanthomatosis (HP:0000991)2.03558708
71Bronchomalacia (HP:0002780)2.02709772
72Vascular tortuosity (HP:0004948)2.01230982
73Striae distensae (HP:0001065)2.00848122
74Myocardial infarction (HP:0001658)1.98811324
75Abnormality of oral frenula (HP:0000190)1.97134383
76Generalized amyotrophy (HP:0003700)1.97079338
77Difficulty climbing stairs (HP:0003551)1.96029842
78Glomerulonephritis (HP:0000099)1.95911162
79Spinal cord lesions (HP:0100561)1.95895365
80Syringomyelia (HP:0003396)1.95895365
81Natal tooth (HP:0000695)1.95629154
82Type 1 muscle fiber predominance (HP:0003803)1.94866166
83Disinhibition (HP:0000734)1.94641980
84Axonal loss (HP:0003447)1.94327181
85Abnormality of liposaccharide metabolism (HP:0010968)1.93923284
86Abnormality of glycosphingolipid metabolism (HP:0004343)1.93923284
87Abnormality of glycolipid metabolism (HP:0010969)1.93923284
88Abnormality of the distal phalanges of the toes (HP:0010182)1.91671757
89Asymmetry of the thorax (HP:0001555)1.91322905
90Biconcave vertebral bodies (HP:0004586)1.90436670
91Mitral regurgitation (HP:0001653)1.90374672
92Spinal rigidity (HP:0003306)1.89629116
93Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.89145581
94Right ventricular cardiomyopathy (HP:0011663)1.88566335
95Selective tooth agenesis (HP:0001592)1.86034728
96Limb-girdle muscle atrophy (HP:0003797)1.83727870
97Scapular winging (HP:0003691)1.82665962
98Soft skin (HP:0000977)1.81312709
99Patellar dislocation (HP:0002999)1.81090497
100Cervical subluxation (HP:0003308)1.81065741
101Ankyloglossia (HP:0010296)1.80241107
102Cerebral inclusion bodies (HP:0100314)1.79120506
103Persistence of primary teeth (HP:0006335)1.79041731
104Mildly elevated creatine phosphokinase (HP:0008180)1.76396099
105Wrist flexion contracture (HP:0001239)1.76207268
106Cortical dysplasia (HP:0002539)1.76127325
107Joint laxity (HP:0001388)1.74663026
108Abnormality of glutamine family amino acid metabolism (HP:0010902)1.74528277
109Redundant skin (HP:0001582)1.74498648
110Neonatal short-limb short stature (HP:0008921)1.73672212
111Nephritis (HP:0000123)1.73265494
112Buphthalmos (HP:0000557)1.73236095
113Asymmetric septal hypertrophy (HP:0001670)1.73161520
114Abnormality of dentin (HP:0010299)1.72989160
115Hyperextensible skin (HP:0000974)1.72963942
116Multiple enchondromatosis (HP:0005701)1.72768635
117Arnold-Chiari malformation (HP:0002308)1.72473344
118Abnormality of the acetabulum (HP:0003170)1.72295330
119Nuclear cataract (HP:0100018)1.71920825
120Hamartoma of the eye (HP:0010568)1.70008472
121Obstructive sleep apnea (HP:0002870)1.69890171
122Multiple lipomas (HP:0001012)1.69790529
123Slender build (HP:0001533)1.69424365
124Arterial tortuosity (HP:0005116)1.68064271
125Abnormality of the distal phalanx of the thumb (HP:0009617)1.67337286
126Exercise-induced muscle cramps (HP:0003710)1.66594015
127Advanced eruption of teeth (HP:0006288)1.66417465
128Supranuclear gaze palsy (HP:0000605)1.65840646
129Exostoses (HP:0100777)1.65839120
130Congenital glaucoma (HP:0001087)1.64676050
131Conjunctival hamartoma (HP:0100780)1.64410213
132Short 4th metacarpal (HP:0010044)1.64258460
133Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.64258460
134Chondrocalcinosis (HP:0000934)1.63658486
135Hypercalcemia (HP:0003072)1.63408918
136Abnormal ossification of hand bones (HP:0005921)1.62841770
137Venous abnormality (HP:0002624)1.62419865
138Abnormality of the 4th metacarpal (HP:0010012)1.61946033
139Diminished motivation (HP:0000745)1.60692326
140Abnormality of the lower motor neuron (HP:0002366)1.60675662
141Spinal cord compression (HP:0002176)1.60539789
142Frequent falls (HP:0002359)1.60454734
143Upper motor neuron abnormality (HP:0002127)1.60397576
144Apathy (HP:0000741)1.59741445
145Insidious onset (HP:0003587)1.59732639
146Termporal pattern (HP:0011008)1.59732639
147Cupped ribs (HP:0000887)1.57989216
148Coxa vara (HP:0002812)1.57945921

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.46992211
2PKN24.39880907
3IRAK33.29096441
4SMG12.74579619
5PRPF4B2.74372932
6TTN2.53850407
7PDGFRA2.44328113
8BMX2.40777943
9ERN12.36959490
10PTK62.35123388
11NME22.31846973
12MARK12.21116904
13MAP3K102.18128762
14EPHB22.14373564
15RIPK12.08179280
16LATS21.97303492
17DDR21.89940951
18MAP3K21.81845433
19ARAF1.80754166
20EEF2K1.73078934
21LATS11.72024747
22KSR21.61654577
23TESK21.57916983
24SCYL21.57282654
25TAOK21.54561978
26LRRK21.42341076
27TESK11.41314445
28SIK11.36371532
29MAP3K91.35940392
30RET1.34837931
31TYRO31.30939505
32NEK11.29890554
33TAOK11.28777070
34MOS1.27913714
35PAK41.26411448
36ICK1.24334052
37PAK31.21117347
38FGFR11.19434012
39LIMK11.18042248
40KSR11.17599219
41PAK61.17172788
42PTK21.13791952
43FGFR41.13055360
44MAP2K31.10681477
45ERBB31.10067628
46ILK1.08342447
47CDK61.07870896
48DMPK1.06502143
49PAK21.05549207
50PIM21.05112689
51MAP3K131.04926670
52EPHA31.01910779
53BRAF1.01808096
54ALK1.00694543
55MINK10.99372659
56FER0.97135395
57MST1R0.95622816
58PDGFRB0.95310363
59CAMKK10.93764946
60ERBB40.90186318
61MTOR0.87349977
62MAP3K40.85355868
63FGFR20.83485168
64PRKD20.83284660
65CAMK1D0.83229032
66PRKCH0.82997138
67PRKD30.80064312
68TGFBR20.79220894
69MET0.78350098
70MAP3K10.76917409
71EPHB10.75343278
72NTRK10.74969216
73MAP2K10.73762541
74EPHA20.71708169
75ZAP700.70277843
76CAMK1G0.67699331
77PDPK10.66324401
78IRAK20.65924187
79DYRK1B0.65258520
80MAP3K30.64047433
81LMTK20.63638411
82STK30.63019889
83MAP3K70.62743061
84MAP3K60.62663759
85MAP3K110.61023406
86MARK20.60687179
87TBK10.60406244
88ERBB20.60191646
89EGFR0.59728833
90FGFR30.59702671
91PRKG20.57971190
92ROCK10.57744791
93MAP3K140.57177362
94DAPK20.56772961
95NEK90.55734009
96FRK0.55489048
97CDK140.53780820
98PHKG10.53670850
99PHKG20.53670850
100CDK70.52079470
101FGR0.50357380
102IRAK40.50217697
103RPS6KA20.49975345
104STK380.49180619
105DAPK30.48975425
106CDK150.48264717
107ABL20.47464637
108CDK180.47233538
109PBK0.46741866
110GSK3A0.46279896
111RPS6KA10.45806254
112MAP2K40.45479832
113SRC0.44316163
114CDC42BPA0.42789849
115RPS6KB20.42426605
116PRKD10.42329319
117NTRK20.42179930
118MAPK110.41442989
119MAP3K50.40700747
120AKT20.40379119
121BLK0.40138535
122CLK10.40056064
123PTK2B0.39940496
124PAK10.39878923
125SIK30.39314503
126ROCK20.38802396
127SIK20.38622333
128CDK11A0.38389016
129MAP3K80.38110367
130PRKCZ0.37520311
131CDK50.36973652
132RPS6KL10.36833720
133RPS6KC10.36833720
134FYN0.36372891
135CDK40.35707889
136RAF10.35439515
137CSNK1G20.35414675
138CDK120.34858074
139CDK90.32344100
140AURKA0.31398263
141MAP2K20.29730635

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.59129855
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.42346132
3Other glycan degradation_Homo sapiens_hsa005112.20546197
4Nitrogen metabolism_Homo sapiens_hsa009101.98742199
5Complement and coagulation cascades_Homo sapiens_hsa046101.93703514
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.84351642
7Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.72081403
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.69496736
9Thyroid cancer_Homo sapiens_hsa052161.64789210
10Focal adhesion_Homo sapiens_hsa045101.61404895
11Chronic myeloid leukemia_Homo sapiens_hsa052201.57804146
12Proteoglycans in cancer_Homo sapiens_hsa052051.57480993
13Amoebiasis_Homo sapiens_hsa051461.50756733
14Vibrio cholerae infection_Homo sapiens_hsa051101.49234236
15Acute myeloid leukemia_Homo sapiens_hsa052211.47721543
16mTOR signaling pathway_Homo sapiens_hsa041501.46987157
17Glioma_Homo sapiens_hsa052141.44704592
18Staphylococcus aureus infection_Homo sapiens_hsa051501.40632976
19Notch signaling pathway_Homo sapiens_hsa043301.39633764
20Pentose phosphate pathway_Homo sapiens_hsa000301.38376221
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38017976
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.35344100
23Galactose metabolism_Homo sapiens_hsa000521.31884105
24ECM-receptor interaction_Homo sapiens_hsa045121.30503206
25Endometrial cancer_Homo sapiens_hsa052131.28390702
26Fructose and mannose metabolism_Homo sapiens_hsa000511.26566787
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.26034109
28Arginine biosynthesis_Homo sapiens_hsa002201.22613765
29ErbB signaling pathway_Homo sapiens_hsa040121.20732091
30Adherens junction_Homo sapiens_hsa045201.19654577
31Bladder cancer_Homo sapiens_hsa052191.19440678
32Fatty acid degradation_Homo sapiens_hsa000711.12490534
33Fat digestion and absorption_Homo sapiens_hsa049751.11493449
34Insulin resistance_Homo sapiens_hsa049311.11234758
35PPAR signaling pathway_Homo sapiens_hsa033201.10412591
36Renal cell carcinoma_Homo sapiens_hsa052111.10206230
37Neurotrophin signaling pathway_Homo sapiens_hsa047221.09587368
38Hippo signaling pathway_Homo sapiens_hsa043901.09034311
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08202739
40Prion diseases_Homo sapiens_hsa050201.08054217
41VEGF signaling pathway_Homo sapiens_hsa043701.07853097
42Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05908889
43Pancreatic cancer_Homo sapiens_hsa052121.02892521
44Apoptosis_Homo sapiens_hsa042101.02412914
45Insulin signaling pathway_Homo sapiens_hsa049101.01551481
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00577584
47Small cell lung cancer_Homo sapiens_hsa052221.00566245
48Viral myocarditis_Homo sapiens_hsa054160.99710594
49Lysosome_Homo sapiens_hsa041420.98296725
50Protein digestion and absorption_Homo sapiens_hsa049740.97604732
51Dilated cardiomyopathy_Homo sapiens_hsa054140.97507547
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97490418
53Fatty acid metabolism_Homo sapiens_hsa012120.96411984
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95531821
55Osteoclast differentiation_Homo sapiens_hsa043800.93968369
56Leishmaniasis_Homo sapiens_hsa051400.93670246
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92873336
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92316946
59Tryptophan metabolism_Homo sapiens_hsa003800.91248729
60Non-small cell lung cancer_Homo sapiens_hsa052230.90826710
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.89481292
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89075362
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.88912447
64Hepatitis B_Homo sapiens_hsa051610.88647887
65HIF-1 signaling pathway_Homo sapiens_hsa040660.88334482
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.88076375
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87833342
68Carbon metabolism_Homo sapiens_hsa012000.87169827
69Axon guidance_Homo sapiens_hsa043600.87098293
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86174533
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86008067
72Hepatitis C_Homo sapiens_hsa051600.85364108
73Colorectal cancer_Homo sapiens_hsa052100.85312863
74Toxoplasmosis_Homo sapiens_hsa051450.84930120
75Estrogen signaling pathway_Homo sapiens_hsa049150.84339327
76Bile secretion_Homo sapiens_hsa049760.83022093
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.82941854
78B cell receptor signaling pathway_Homo sapiens_hsa046620.82631642
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82039277
80Caffeine metabolism_Homo sapiens_hsa002320.81935950
81MicroRNAs in cancer_Homo sapiens_hsa052060.81824932
82Type II diabetes mellitus_Homo sapiens_hsa049300.80567295
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.80503590
84AMPK signaling pathway_Homo sapiens_hsa041520.79821657
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79218783
86TNF signaling pathway_Homo sapiens_hsa046680.78308959
87N-Glycan biosynthesis_Homo sapiens_hsa005100.77567412
88Biosynthesis of amino acids_Homo sapiens_hsa012300.76457717
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.75968855
90Pertussis_Homo sapiens_hsa051330.75452669
91Legionellosis_Homo sapiens_hsa051340.74612055
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72963565
93Endocytosis_Homo sapiens_hsa041440.72802408
94TGF-beta signaling pathway_Homo sapiens_hsa043500.72635266
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72191470
96Lysine degradation_Homo sapiens_hsa003100.71574630
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71321333
98Viral carcinogenesis_Homo sapiens_hsa052030.70816755
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70738058
100Sulfur relay system_Homo sapiens_hsa041220.70681819
101Pathways in cancer_Homo sapiens_hsa052000.69762591
102Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69155380
103HTLV-I infection_Homo sapiens_hsa051660.69136012
104Tuberculosis_Homo sapiens_hsa051520.68618313
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68593999
106Phagosome_Homo sapiens_hsa041450.68498529
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67702885
108GnRH signaling pathway_Homo sapiens_hsa049120.67218981
109Tight junction_Homo sapiens_hsa045300.67204619
110Basal cell carcinoma_Homo sapiens_hsa052170.67005607
111Melanoma_Homo sapiens_hsa052180.66927312
112Gap junction_Homo sapiens_hsa045400.66200256
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65919157
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65196970
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65150945
116Dorso-ventral axis formation_Homo sapiens_hsa043200.64826433
117Salmonella infection_Homo sapiens_hsa051320.64033382
118Prolactin signaling pathway_Homo sapiens_hsa049170.63878111
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63863158
120Influenza A_Homo sapiens_hsa051640.61810754
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.61634117
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61032811
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60673092
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60381951
125Glucagon signaling pathway_Homo sapiens_hsa049220.60285854
126Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59745968
127Rap1 signaling pathway_Homo sapiens_hsa040150.58690454
128Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58632198
129Shigellosis_Homo sapiens_hsa051310.58339292
130Platelet activation_Homo sapiens_hsa046110.56823997
131Butanoate metabolism_Homo sapiens_hsa006500.56720742
132Prostate cancer_Homo sapiens_hsa052150.56604144
133Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56092491
134FoxO signaling pathway_Homo sapiens_hsa040680.55680392
135Choline metabolism in cancer_Homo sapiens_hsa052310.55049666
136Melanogenesis_Homo sapiens_hsa049160.52664586
137mRNA surveillance pathway_Homo sapiens_hsa030150.51104708
138Malaria_Homo sapiens_hsa051440.47650412
139Inositol phosphate metabolism_Homo sapiens_hsa005620.47641204

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