YEATS4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.76712452
2viral transcription (GO:0019083)4.70312401
3ribosomal small subunit assembly (GO:0000028)4.66662212
4translational termination (GO:0006415)4.57837973
5DNA unwinding involved in DNA replication (GO:0006268)4.53648978
6DNA deamination (GO:0045006)4.53039141
7DNA strand elongation (GO:0022616)4.50898205
8telomere maintenance via semi-conservative replication (GO:0032201)4.37142877
9maturation of SSU-rRNA (GO:0030490)4.27286321
10DNA replication initiation (GO:0006270)4.20917531
11translational elongation (GO:0006414)4.15649314
12ribosomal small subunit biogenesis (GO:0042274)4.04132640
13translational initiation (GO:0006413)3.99522672
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.96037632
15DNA replication checkpoint (GO:0000076)3.93351541
16telomere maintenance via recombination (GO:0000722)3.92083136
17protein localization to kinetochore (GO:0034501)3.89922799
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.88729101
19formation of translation preinitiation complex (GO:0001731)3.88334571
20mitotic metaphase plate congression (GO:0007080)3.84427641
21synapsis (GO:0007129)3.84143675
22ribosomal large subunit biogenesis (GO:0042273)3.77908036
23mitotic recombination (GO:0006312)3.76894814
24cotranslational protein targeting to membrane (GO:0006613)3.76637086
25protein targeting to ER (GO:0045047)3.76058201
26regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.74483164
27regulation of mitotic spindle checkpoint (GO:1903504)3.74483164
28DNA double-strand break processing (GO:0000729)3.74388515
29protein localization to chromosome, centromeric region (GO:0071459)3.67471790
30DNA ligation (GO:0006266)3.64724966
31viral life cycle (GO:0019058)3.58928590
32cellular protein complex disassembly (GO:0043624)3.58189183
33establishment of protein localization to endoplasmic reticulum (GO:0072599)3.56006781
34mitotic nuclear envelope disassembly (GO:0007077)3.52400819
35telomere maintenance via telomere lengthening (GO:0010833)3.51875046
36folic acid-containing compound biosynthetic process (GO:0009396)3.51633020
37protein localization to endoplasmic reticulum (GO:0070972)3.51045884
38CENP-A containing nucleosome assembly (GO:0034080)3.50578259
39DNA replication-dependent nucleosome assembly (GO:0006335)3.50269398
40DNA replication-dependent nucleosome organization (GO:0034723)3.50269398
41chromatin remodeling at centromere (GO:0031055)3.50240105
42DNA replication-independent nucleosome assembly (GO:0006336)3.47333449
43DNA replication-independent nucleosome organization (GO:0034724)3.47333449
44negative regulation of RNA splicing (GO:0033119)3.47137745
45regulation of helicase activity (GO:0051095)3.44819680
46regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.43833325
47ribonucleoprotein complex biogenesis (GO:0022613)3.43108267
48mitotic chromosome condensation (GO:0007076)3.41380228
49protein complex disassembly (GO:0043241)3.40027566
50kinetochore organization (GO:0051383)3.39918553
51nucleotide-excision repair, DNA gap filling (GO:0006297)3.38373649
52metaphase plate congression (GO:0051310)3.32774342
53attachment of spindle microtubules to kinetochore (GO:0008608)3.29539398
54negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.29254976
55membrane disassembly (GO:0030397)3.28339321
56nuclear envelope disassembly (GO:0051081)3.28339321
57mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.27896756
58nucleobase biosynthetic process (GO:0046112)3.25583557
59spliceosomal snRNP assembly (GO:0000387)3.23818014
60mitotic G2/M transition checkpoint (GO:0044818)3.23711518
61nuclear-transcribed mRNA catabolic process (GO:0000956)3.22577074
62macromolecular complex disassembly (GO:0032984)3.22358511
63deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.18459647
64negative regulation of DNA-dependent DNA replication (GO:2000104)3.18366826
65mitotic spindle checkpoint (GO:0071174)3.17233432
66kinetochore assembly (GO:0051382)3.17154305
67ribosome biogenesis (GO:0042254)3.14629431
68resolution of meiotic recombination intermediates (GO:0000712)3.12432706
69replication fork processing (GO:0031297)3.12316371
70rRNA processing (GO:0006364)3.11801511
71purine nucleobase biosynthetic process (GO:0009113)3.09947530
72cullin deneddylation (GO:0010388)3.08651056
73regulation of centriole replication (GO:0046599)3.08528408
74rRNA modification (GO:0000154)3.07732665
75mRNA catabolic process (GO:0006402)3.06349509
76histone exchange (GO:0043486)3.03724697
77RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.03234498
78tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.03234498
79somatic diversification of immune receptors via somatic mutation (GO:0002566)3.02680282
80somatic hypermutation of immunoglobulin genes (GO:0016446)3.02680282
81RNA catabolic process (GO:0006401)3.02448456
82rRNA metabolic process (GO:0016072)3.01893462
83establishment of chromosome localization (GO:0051303)3.01679313
84nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01588538
85regulation of DNA endoreduplication (GO:0032875)3.01253763
86DNA catabolic process, exonucleolytic (GO:0000738)3.00957564
87positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.99682282
88negative regulation of DNA recombination (GO:0045910)2.98147253
89positive regulation of histone H3-K4 methylation (GO:0051571)2.97544756
90mitotic sister chromatid segregation (GO:0000070)2.97473987
91regulation of mitotic metaphase/anaphase transition (GO:0030071)2.97245621
92regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.97245621
93termination of RNA polymerase II transcription (GO:0006369)2.96927951
94negative regulation of chromosome segregation (GO:0051985)2.94924701
95negative regulation of mitotic sister chromatid separation (GO:2000816)2.94670527
96negative regulation of mitotic sister chromatid segregation (GO:0033048)2.94670527
97negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.94670527
98negative regulation of sister chromatid segregation (GO:0033046)2.94670527
99chromatin assembly or disassembly (GO:0006333)2.94104203
100ribosome assembly (GO:0042255)2.93716925
101translation (GO:0006412)2.93628556
102meiotic chromosome segregation (GO:0045132)2.93614406
103RNA splicing, via transesterification reactions (GO:0000375)2.92837194
104mRNA splicing, via spliceosome (GO:0000398)2.92812970
105RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.92812970
106protein localization to chromosome (GO:0034502)2.92380020
107mitochondrial RNA metabolic process (GO:0000959)2.91415462
108negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.91376733
109mitotic spindle assembly checkpoint (GO:0007094)2.91358470
110regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.91277302
111somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.90955986
112isotype switching (GO:0045190)2.90955986
113somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.90955986
114establishment of protein localization to mitochondrial membrane (GO:0090151)2.90402502
115spindle assembly checkpoint (GO:0071173)2.90301460
116dosage compensation (GO:0007549)2.90207651
117regulation of mitotic sister chromatid separation (GO:0010965)2.89923733
118regulation of mitotic sister chromatid segregation (GO:0033047)2.89923733
119regulation of sister chromatid segregation (GO:0033045)2.89923733
120anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.89543055
121double-strand break repair via nonhomologous end joining (GO:0006303)2.89349694
122non-recombinational repair (GO:0000726)2.89349694
123regulation of double-strand break repair via homologous recombination (GO:0010569)2.89143525
124establishment of integrated proviral latency (GO:0075713)2.89014554
125ATP-dependent chromatin remodeling (GO:0043044)2.87543368
126protein deneddylation (GO:0000338)2.86907509
127mitotic G2 DNA damage checkpoint (GO:0007095)2.86455222
128exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.86377491
129translesion synthesis (GO:0019985)2.85827512
130negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.85482773
131negative regulation of ligase activity (GO:0051352)2.85482773
132spindle checkpoint (GO:0031577)2.84439934
133DNA duplex unwinding (GO:0032508)2.83868142
134pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.83398182
135chaperone-mediated protein transport (GO:0072321)2.81008974
136base-excision repair (GO:0006284)2.80929746
137DNA geometric change (GO:0032392)2.80901407
138negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.80691793
139spliceosomal complex assembly (GO:0000245)2.80463772
140pseudouridine synthesis (GO:0001522)2.80406968
141sister chromatid segregation (GO:0000819)2.80347225
142proteasome assembly (GO:0043248)2.80316086
143maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.80220477
144regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.79941244
145IMP biosynthetic process (GO:0006188)2.79637410
146histone mRNA metabolic process (GO:0008334)2.79034002
147mismatch repair (GO:0006298)2.78810423
148regulation of mitochondrial translation (GO:0070129)2.78597152
149regulation of chromosome segregation (GO:0051983)2.77438179

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.86636429
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.22855581
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.06763516
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.88819617
5* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.50960108
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.17797459
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.89083975
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.80228169
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.76465115
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73312217
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.70309579
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.66894501
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.65732216
14GATA1_22025678_ChIP-Seq_K562_Human2.62917706
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.62300094
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.58094551
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54164347
18XRN2_22483619_ChIP-Seq_HELA_Human2.46390647
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.37333359
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.27228945
21MYC_22102868_ChIP-Seq_BL_Human2.25634869
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23878240
23VDR_23849224_ChIP-Seq_CD4+_Human2.17601377
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.11338819
25ZNF274_21170338_ChIP-Seq_K562_Hela2.06260833
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03501295
27DCP1A_22483619_ChIP-Seq_HELA_Human2.00683328
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.00373653
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99648841
30FOXP3_21729870_ChIP-Seq_TREG_Human1.99234800
31CIITA_25753668_ChIP-Seq_RAJI_Human1.94121816
32* E2F1_21310950_ChIP-Seq_MCF-7_Human1.93661298
33TTF2_22483619_ChIP-Seq_HELA_Human1.92942183
34* GABP_19822575_ChIP-Seq_HepG2_Human1.92592153
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89454089
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87466446
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85157976
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84431380
39FUS_26573619_Chip-Seq_HEK293_Human1.79984730
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79828142
41AR_21909140_ChIP-Seq_LNCAP_Human1.76756840
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.75581395
43* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73836702
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.73214015
45EWS_26573619_Chip-Seq_HEK293_Human1.71752194
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67211955
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61092641
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60827325
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57488148
50* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56344609
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56226890
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.55406577
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50400698
54VDR_21846776_ChIP-Seq_THP-1_Human1.50339933
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50212719
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50109904
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48624884
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48123559
59KDM5A_27292631_Chip-Seq_BREAST_Human1.45095590
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44945651
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.44072330
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40448856
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39908499
64IGF1R_20145208_ChIP-Seq_DFB_Human1.39268698
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38894908
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36009492
67ELK1_19687146_ChIP-ChIP_HELA_Human1.32415769
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32009242
69VDR_22108803_ChIP-Seq_LS180_Human1.31190558
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29706570
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27655945
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27014903
73* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26451599
74* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24473546
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23511625
76* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.20280693
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.16735968
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16604131
79SRF_21415370_ChIP-Seq_HL-1_Mouse1.14851320
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13610800
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13319233
82SPI1_23547873_ChIP-Seq_NB4_Human1.12967298
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10519769
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10514135
85TFEB_21752829_ChIP-Seq_HELA_Human1.09835475
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09756002
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09506588
88MYC_18940864_ChIP-ChIP_HL60_Human1.08677375
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08348186
90NANOG_16153702_ChIP-ChIP_HESCs_Human1.08119537
91STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06224348
92SOX2_16153702_ChIP-ChIP_HESCs_Human1.05681092
93IRF1_19129219_ChIP-ChIP_H3396_Human1.04924959
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03750716
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02853124
96SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.02687959
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01028200
98FLI1_27457419_Chip-Seq_LIVER_Mouse1.00566907
99E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99862133
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99363428
101SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97898359
102CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97750493
103PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95026270
104NANOG_21062744_ChIP-ChIP_HESCs_Human0.94745112
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93859857
106SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93777991
107UTX_26944678_Chip-Seq_JUKART_Human0.92443779
108CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91916712
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89188476
110CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88975751
111P300_19829295_ChIP-Seq_ESCs_Human0.88446733
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85421425
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85340641
114ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83064411
115FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.82993251
116PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.82592670
117MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.82058067
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81087765
119EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80605698
120TAF15_26573619_Chip-Seq_HEK293_Human0.80343952
121* MAF_26560356_Chip-Seq_TH1_Human0.80226955
122HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.78658742
123CTBP1_25329375_ChIP-Seq_LNCAP_Human0.77931298
124PCGF2_27294783_Chip-Seq_ESCs_Mouse0.77516147
125ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.77381563
126* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77102194
127* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76892295
128RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.76870951
129MAF_26560356_Chip-Seq_TH2_Human0.76587892
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.72642442
131ELK1_22589737_ChIP-Seq_MCF10A_Human0.72166890
132ZNF263_19887448_ChIP-Seq_K562_Human0.71188880
133CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.68492307
134CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.68037355
135NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.66477605

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.52278693
2MP0010094_abnormal_chromosome_stability4.29526332
3MP0004957_abnormal_blastocyst_morpholog4.17481745
4MP0003111_abnormal_nucleus_morphology4.11649257
5MP0003077_abnormal_cell_cycle3.87694083
6MP0008058_abnormal_DNA_repair3.16849902
7MP0008057_abnormal_DNA_replication3.15259044
8MP0008007_abnormal_cellular_replicative2.69742272
9MP0002396_abnormal_hematopoietic_system2.68231049
10MP0008932_abnormal_embryonic_tissue2.43165745
11MP0003123_paternal_imprinting2.33793374
12MP0001730_embryonic_growth_arrest2.20662968
13MP0000350_abnormal_cell_proliferation2.19112340
14MP0000490_abnormal_crypts_of2.06282849
15MP0008877_abnormal_DNA_methylation2.05968771
16MP0003136_yellow_coat_color2.04905453
17MP0000372_irregular_coat_pigmentation2.04612941
18MP0010352_gastrointestinal_tract_polyps2.01033715
19MP0004147_increased_porphyrin_level1.94966391
20MP0006035_abnormal_mitochondrial_morpho1.94415651
21MP0009697_abnormal_copulation1.84203628
22MP0006072_abnormal_retinal_apoptosis1.80868611
23MP0001529_abnormal_vocalization1.79662841
24MP0005645_abnormal_hypothalamus_physiol1.73008638
25MP0002938_white_spotting1.71072496
26MP0001697_abnormal_embryo_size1.69469410
27MP0004808_abnormal_hematopoietic_stem1.67602624
28MP0002019_abnormal_tumor_incidence1.62177118
29MP0003890_abnormal_embryonic-extraembry1.61638979
30MP0003763_abnormal_thymus_physiology1.55602588
31MP0000313_abnormal_cell_death1.55505820
32MP0001672_abnormal_embryogenesis/_devel1.54192743
33MP0005380_embryogenesis_phenotype1.54192743
34MP0002653_abnormal_ependyma_morphology1.53942105
35MP0002080_prenatal_lethality1.52859704
36MP0009333_abnormal_splenocyte_physiolog1.51614968
37MP0002085_abnormal_embryonic_tissue1.50093568
38MP0003786_premature_aging1.49736241
39MP0003941_abnormal_skin_development1.48263317
40MP0006292_abnormal_olfactory_placode1.48046549
41MP0002398_abnormal_bone_marrow1.47412808
42MP0008995_early_reproductive_senescence1.47359114
43MP0003315_abnormal_perineum_morphology1.47174784
44MP0003121_genomic_imprinting1.44496868
45MP0010307_abnormal_tumor_latency1.43640090
46MP0006036_abnormal_mitochondrial_physio1.43309620
47MP0003984_embryonic_growth_retardation1.39259537
48MP0002084_abnormal_developmental_patter1.39071804
49MP0002088_abnormal_embryonic_growth/wei1.36982164
50MP0003806_abnormal_nucleotide_metabolis1.35983218
51MP0010030_abnormal_orbit_morphology1.35814932
52MP0002210_abnormal_sex_determination1.34160063
53MP0000703_abnormal_thymus_morphology1.33907604
54MP0003186_abnormal_redox_activity1.30501746
55MP0001545_abnormal_hematopoietic_system1.30462802
56MP0005397_hematopoietic_system_phenotyp1.30462802
57MP0005076_abnormal_cell_differentiation1.28163259
58MP0002722_abnormal_immune_system1.28114057
59MP0005394_taste/olfaction_phenotype1.27672402
60MP0005499_abnormal_olfactory_system1.27672402
61MP0000689_abnormal_spleen_morphology1.26264433
62MP0002102_abnormal_ear_morphology1.24461279
63MP0003567_abnormal_fetal_cardiomyocyte1.24033631
64MP0002086_abnormal_extraembryonic_tissu1.19354818
65MP0001145_abnormal_male_reproductive1.18628682
66MP0003937_abnormal_limbs/digits/tail_de1.18452031
67MP0003718_maternal_effect1.17895795
68MP0005389_reproductive_system_phenotype1.17399366
69MP0000631_abnormal_neuroendocrine_gland1.15431915
70MP0002234_abnormal_pharynx_morphology1.14981830
71MP0004197_abnormal_fetal_growth/weight/1.14677162
72MP0002429_abnormal_blood_cell1.14120380
73MP0001293_anophthalmia1.13109181
74MP0001764_abnormal_homeostasis1.12283304
75MP0001929_abnormal_gametogenesis1.11511891
76MP0000685_abnormal_immune_system1.09823753
77MP0001188_hyperpigmentation1.08747370
78MP0005253_abnormal_eye_physiology1.08151779
79MP0001800_abnormal_humoral_immune1.05017264
80MP0000716_abnormal_immune_system1.04710778
81MP0001835_abnormal_antigen_presentation1.04601812
82MP0005551_abnormal_eye_electrophysiolog1.04034567
83MP0003119_abnormal_digestive_system1.03606227
84MP0000653_abnormal_sex_gland1.03369471
85MP0006276_abnormal_autonomic_nervous1.02591441
86MP0002233_abnormal_nose_morphology1.02435326
87MP0002837_dystrophic_cardiac_calcinosis1.02281987
88MP0000858_altered_metastatic_potential1.01559121
89MP0005174_abnormal_tail_pigmentation0.98949352
90MP0005367_renal/urinary_system_phenotyp0.96416611
91MP0000516_abnormal_urinary_system0.96416611
92MP0002420_abnormal_adaptive_immunity0.93626634
93MP0003221_abnormal_cardiomyocyte_apopto0.93548577
94MP0000358_abnormal_cell_content/0.92412830
95MP0001119_abnormal_female_reproductive0.92234533
96MP0001819_abnormal_immune_cell0.91710813
97MP0002452_abnormal_antigen_presenting0.90162187
98MP0002638_abnormal_pupillary_reflex0.89951932
99MP0000049_abnormal_middle_ear0.89859207
100MP0004215_abnormal_myocardial_fiber0.89812954
101MP0001485_abnormal_pinna_reflex0.88035177
102MP0002751_abnormal_autonomic_nervous0.87815514
103MP0002405_respiratory_system_inflammati0.87769853
104MP0008789_abnormal_olfactory_epithelium0.87522505
105MP0001984_abnormal_olfaction0.85765682
106MP0002736_abnormal_nociception_after0.85023685
107MP0000465_gastrointestinal_hemorrhage0.84564089
108MP0009278_abnormal_bone_marrow0.83181020
109MP0005671_abnormal_response_to0.83011190
110MP0002697_abnormal_eye_size0.82514752
111MP0001915_intracranial_hemorrhage0.82355471
112MP0005377_hearing/vestibular/ear_phenot0.82089180
113MP0003878_abnormal_ear_physiology0.82089180
114MP0002006_tumorigenesis0.81579259
115MP0003436_decreased_susceptibility_to0.80864129
116MP0000427_abnormal_hair_cycle0.80746175
117MP0005391_vision/eye_phenotype0.80624744
118MP0006054_spinal_hemorrhage0.79994347
119MP0003880_abnormal_central_pattern0.79952206
120MP0009672_abnormal_birth_weight0.79502162
121MP0002723_abnormal_immune_serum0.79188869
122MP0000537_abnormal_urethra_morphology0.78910319
123MP0004133_heterotaxia0.76887752
124MP0002161_abnormal_fertility/fecundity0.76267700
125MP0000477_abnormal_intestine_morphology0.76026731
126MP0002166_altered_tumor_susceptibility0.75839971
127MP0005384_cellular_phenotype0.75118670
128MP0005075_abnormal_melanosome_morpholog0.73948594
129MP0003943_abnormal_hepatobiliary_system0.73605575
130MP0005195_abnormal_posterior_eye0.72474590
131MP0003283_abnormal_digestive_organ0.72347657
132MP0002090_abnormal_vision0.71107281
133MP0000647_abnormal_sebaceous_gland0.70345316
134MP0009703_decreased_birth_body0.70107814
135MP0005025_abnormal_response_to0.68674567
136MP0005395_other_phenotype0.66889166
137MP0004142_abnormal_muscle_tone0.66729325
138MP0009785_altered_susceptibility_to0.66557469
139MP0002822_catalepsy0.65508174
140MP0002095_abnormal_skin_pigmentation0.65324809
141MP0005000_abnormal_immune_tolerance0.64662281
142MP0003646_muscle_fatigue0.64253987
143MP0005451_abnormal_body_composition0.64171363
144MP0005621_abnormal_cell_physiology0.64104877
145MP0010155_abnormal_intestine_physiology0.64053271
146MP0009053_abnormal_anal_canal0.63218672
147MP0002160_abnormal_reproductive_system0.61120495
148MP0002132_abnormal_respiratory_system0.59397797
149MP0002092_abnormal_eye_morphology0.58998574
150MP0001286_abnormal_eye_development0.58812723
151MP0003699_abnormal_female_reproductive0.57762140
152MP0003698_abnormal_male_reproductive0.57547325

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.95994791
2Reticulocytopenia (HP:0001896)4.82418048
3Abnormal number of erythroid precursors (HP:0012131)4.56542412
4Birth length less than 3rd percentile (HP:0003561)3.80374946
5Aplastic anemia (HP:0001915)3.73380329
6Generalized aminoaciduria (HP:0002909)3.65795740
7Pallor (HP:0000980)3.40229749
8Degeneration of anterior horn cells (HP:0002398)3.36239538
9Abnormality of the anterior horn cell (HP:0006802)3.36239538
10Colon cancer (HP:0003003)3.30838460
11Medulloblastoma (HP:0002885)3.23986150
12Patellar aplasia (HP:0006443)3.23392666
13Oral leukoplakia (HP:0002745)3.17475999
14Abnormality of the labia minora (HP:0012880)3.15814147
15Macrocytic anemia (HP:0001972)3.11884430
16Aplasia/Hypoplasia of the patella (HP:0006498)3.08460219
17Acute necrotizing encephalopathy (HP:0006965)3.01143019
18Chromsome breakage (HP:0040012)2.93800359
19Microretrognathia (HP:0000308)2.83168417
20Acute encephalopathy (HP:0006846)2.80535002
21Mitochondrial inheritance (HP:0001427)2.74571797
22Abnormality of chromosome stability (HP:0003220)2.74274443
23Pancreatic fibrosis (HP:0100732)2.72493933
24Breast hypoplasia (HP:0003187)2.71742816
25Carpal bone hypoplasia (HP:0001498)2.71727978
26Abnormal mitochondria in muscle tissue (HP:0008316)2.71670015
27Thrombocytosis (HP:0001894)2.71093252
28Increased hepatocellular lipid droplets (HP:0006565)2.68104979
29Multiple enchondromatosis (HP:0005701)2.66914810
30Increased CSF lactate (HP:0002490)2.66873059
31Meckel diverticulum (HP:0002245)2.64382098
32Chromosomal breakage induced by crosslinking agents (HP:0003221)2.60759079
33Myelodysplasia (HP:0002863)2.59156585
34Basal cell carcinoma (HP:0002671)2.58390136
35Abnormality of the ileum (HP:0001549)2.58065946
36Agnosia (HP:0010524)2.57588041
37Progressive macrocephaly (HP:0004481)2.56262236
38Ependymoma (HP:0002888)2.55208560
39Proximal tubulopathy (HP:0000114)2.54954770
40Hepatic necrosis (HP:0002605)2.54715392
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.54113128
42True hermaphroditism (HP:0010459)2.54043654
43Hyperalaninemia (HP:0003348)2.51357748
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.51357748
45Abnormality of alanine metabolism (HP:0010916)2.51357748
46Absent thumb (HP:0009777)2.51269715
47Pancreatic cysts (HP:0001737)2.50636524
48Abnormality of the preputium (HP:0100587)2.47583237
49Volvulus (HP:0002580)2.47319933
50Severe visual impairment (HP:0001141)2.46152236
51Selective tooth agenesis (HP:0001592)2.44607626
52IgM deficiency (HP:0002850)2.43132538
53Hepatocellular necrosis (HP:0001404)2.43123222
54Lipid accumulation in hepatocytes (HP:0006561)2.42511137
55Neoplasm of the pancreas (HP:0002894)2.42244034
56Supernumerary spleens (HP:0009799)2.27610954
57Premature ovarian failure (HP:0008209)2.25978928
58Atrophy/Degeneration involving motor neurons (HP:0007373)2.25962436
59Facial hemangioma (HP:0000329)2.25169347
60Abnormality of serum amino acid levels (HP:0003112)2.25098240
6111 pairs of ribs (HP:0000878)2.24482100
62Abnormality of methionine metabolism (HP:0010901)2.23160139
63Overlapping toe (HP:0001845)2.22176381
64Abnormal number of incisors (HP:0011064)2.21815942
65Pendular nystagmus (HP:0012043)2.21040808
66Small intestinal stenosis (HP:0012848)2.20484910
67Duodenal stenosis (HP:0100867)2.20484910
68Bone marrow hypocellularity (HP:0005528)2.19598534
69Rhabdomyosarcoma (HP:0002859)2.19008402
70Gonadotropin excess (HP:0000837)2.16589954
71Prominent nose (HP:0000448)2.15012997
72Cerebral edema (HP:0002181)2.14234586
73Increased serum lactate (HP:0002151)2.11827456
74Atresia of the external auditory canal (HP:0000413)2.11144668
75Cleft eyelid (HP:0000625)2.10977098
76Increased nuchal translucency (HP:0010880)2.10547861
77Lymphoma (HP:0002665)2.09007145
78Abnormality of urine glucose concentration (HP:0011016)2.08996612
79Glycosuria (HP:0003076)2.08996612
80Microvesicular hepatic steatosis (HP:0001414)2.08861731
81Rough bone trabeculation (HP:0100670)2.08769455
82Horseshoe kidney (HP:0000085)2.08756999
83Aplasia/Hypoplasia of the tongue (HP:0010295)2.08511444
84Tracheoesophageal fistula (HP:0002575)2.08303502
85Sclerocornea (HP:0000647)2.07863950
86Triphalangeal thumb (HP:0001199)2.07480826
87Cellular immunodeficiency (HP:0005374)2.05236953
88Abnormal lung lobation (HP:0002101)2.04201139
89Stenosis of the external auditory canal (HP:0000402)2.03090648
90Medial flaring of the eyebrow (HP:0010747)2.01838839
91Preaxial hand polydactyly (HP:0001177)2.01654904
923-Methylglutaconic aciduria (HP:0003535)2.00011967
93Abnormality of aspartate family amino acid metabolism (HP:0010899)1.99424328
94Sloping forehead (HP:0000340)1.99289958
95Poor head control (HP:0002421)1.98875336
96Absent septum pellucidum (HP:0001331)1.97654009
97Septo-optic dysplasia (HP:0100842)1.96848846
98Impulsivity (HP:0100710)1.96506152
99Abdominal situs inversus (HP:0003363)1.96427865
100Abnormality of abdominal situs (HP:0011620)1.96427865
101Lactic acidosis (HP:0003128)1.95606153
102Combined immunodeficiency (HP:0005387)1.95059629
103Congenital primary aphakia (HP:0007707)1.93866251
104Methylmalonic acidemia (HP:0002912)1.93014491
105Abnormality of placental membranes (HP:0011409)1.92979377
106Amniotic constriction ring (HP:0009775)1.92979377
107Hypoglycemic coma (HP:0001325)1.92752206
108Hypoplastic pelvis (HP:0008839)1.92492937
109Nephroblastoma (Wilms tumor) (HP:0002667)1.91355438
110Decreased activity of mitochondrial respiratory chain (HP:0008972)1.91326499
111Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.91326499
112Optic nerve coloboma (HP:0000588)1.90440121
113Abnormality of the duodenum (HP:0002246)1.90429783
114Postaxial foot polydactyly (HP:0001830)1.89575972
115Amaurosis fugax (HP:0100576)1.89256788
116Type I transferrin isoform profile (HP:0003642)1.88332288
117Renal cortical cysts (HP:0000803)1.87926932
118Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.87636533
119Nephrogenic diabetes insipidus (HP:0009806)1.86486400
120Absent radius (HP:0003974)1.85649415
121Gait imbalance (HP:0002141)1.84852700
122Squamous cell carcinoma (HP:0002860)1.84546251
123Embryonal renal neoplasm (HP:0011794)1.84231320
124Pulmonary fibrosis (HP:0002206)1.82239342
125Abnormality of midbrain morphology (HP:0002418)1.82098122
126Molar tooth sign on MRI (HP:0002419)1.82098122
127Abnormality of reticulocytes (HP:0004312)1.81805704
128Abnormality of homocysteine metabolism (HP:0010919)1.81686819
129Homocystinuria (HP:0002156)1.81686819
130Hyperglycinemia (HP:0002154)1.81460842
131Abnormality of the carotid arteries (HP:0005344)1.80690018
132Premature graying of hair (HP:0002216)1.80626914
133Anencephaly (HP:0002323)1.80461190
134Clubbing of toes (HP:0100760)1.80318221
135Median cleft lip (HP:0000161)1.80045142
136Abnormality of DNA repair (HP:0003254)1.79532279
137Genital tract atresia (HP:0001827)1.79023740
138Cafe-au-lait spot (HP:0000957)1.78551318
139Abnormal glycosylation (HP:0012345)1.77976782
140Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77976782
141Abnormal protein N-linked glycosylation (HP:0012347)1.77976782
142Abnormal protein glycosylation (HP:0012346)1.77976782
143Abnormality of T cells (HP:0002843)1.77527983
144Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77234117
145Increased serum pyruvate (HP:0003542)1.77103128
146Proximal placement of thumb (HP:0009623)1.76053434
147Abnormal biliary tract physiology (HP:0012439)1.75949385
148Ectopic kidney (HP:0000086)1.75159555
149Cerebral hypomyelination (HP:0006808)1.74848921
150Slender long bone (HP:0003100)1.74698735
151Aplasia/Hypoplasia of the thymus (HP:0010515)1.74413172
152Abnormality of T cell physiology (HP:0011840)1.72925020
153Trismus (HP:0000211)1.72858911
154Personality changes (HP:0000751)1.72296966
155Abnormality of the fingertips (HP:0001211)1.71765995
156Hypoplasia of the radius (HP:0002984)1.71554386
157Poikiloderma (HP:0001029)1.70902742
158Absent forearm bone (HP:0003953)1.70577660
159Aplasia involving forearm bones (HP:0009822)1.70577660
160Neoplasm of the colon (HP:0100273)1.69210131
161Short 4th metacarpal (HP:0010044)1.68212713
162Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.68212713
163Severe combined immunodeficiency (HP:0004430)1.68211530
164Pancytopenia (HP:0001876)1.68185912
165Acute lymphatic leukemia (HP:0006721)1.67615120
166Neoplasm of striated muscle (HP:0009728)1.67439385

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.04859559
2BUB13.95262839
3WEE13.60848447
4NEK23.16660679
5EIF2AK13.06338401
6TRIM282.62184709
7VRK22.58336398
8DYRK32.54842973
9ZAK2.38252258
10NME22.35132640
11ACVR1B2.34754791
12PASK2.25556696
13MAP3K102.12617638
14SRPK12.12572640
15PBK2.09805951
16MAP4K22.07505528
17CDK192.07348034
18NUAK12.04272867
19EEF2K1.98534808
20TESK21.98276468
21ERBB31.97938843
22SCYL21.93613194
23MAP4K11.92405348
24EIF2AK31.82755993
25MST41.82074821
26PLK11.77323910
27PLK41.76474413
28BMPR1B1.75891999
29NEK11.75270428
30TTK1.75188212
31RPS6KA41.62422395
32CDK71.59396695
33VRK11.57311247
34RPS6KB21.53994755
35WNK31.53844318
36ATR1.49836478
37STK161.47952070
38BRSK21.47619598
39BCR1.47203462
40TLK11.46467277
41AURKB1.44496876
42PKN21.40894644
43CDK41.40626425
44TGFBR11.38912945
45TNIK1.37602363
46CHEK21.33895152
47TAF11.30319842
48CCNB11.26981859
49CDK121.24964063
50CSNK1G31.20756992
51MKNK11.20287630
52AURKA1.19946848
53MAP3K81.19335826
54FRK1.17878689
55PAK41.15210830
56CSNK1G11.11952554
57MAP3K111.10314574
58FLT31.09543291
59BRSK11.06275119
60CSNK1G21.06252983
61MAPKAPK31.04425786
62LRRK21.04119039
63CDK81.04084289
64DYRK21.04037915
65STK101.02329683
66CHEK11.01887542
67PDK21.01085126
68MAP3K40.99133184
69PNCK0.99071659
70PLK30.91106878
71MAP2K70.89485406
72TSSK60.87266578
73PIM10.85815927
74KDR0.84916056
75MAPK130.84631789
76GRK60.83176597
77BTK0.80378758
78CSNK1A1L0.80234467
79TESK10.79311254
80BRAF0.78843208
81ZAP700.77183377
82NME10.75813600
83MKNK20.74229775
84ATM0.72352405
85PLK20.70379394
86CDK20.69291489
87KSR10.68403364
88TAOK20.64781769
89CDK60.64068216
90STK40.63811910
91BRD40.61749080
92TAOK10.59033575
93CSNK2A10.58176427
94CSNK2A20.57288925
95TEC0.57269024
96TRIB30.56831566
97RAF10.56444728
98KIT0.56092121
99PIM20.55323538
100OXSR10.54220949
101MELK0.52599679
102TBK10.52077509
103DYRK1B0.50775892
104ERN10.50392754
105STK38L0.49352773
106PRKCI0.48918351
107ADRBK20.46936041
108CSNK1E0.46908893
109STK30.46359949
110PAK10.44838896
111CDK10.44738542
112NLK0.44600740
113JAK30.43371788
114CSF1R0.43342242
115CDK11A0.42892723
116RPS6KA50.41793265
117CDK90.41675555
118EIF2AK20.41582384
119CDK180.41071044
120ALK0.40629441
121PRKCG0.39640542
122PRKDC0.39430157
123MAP2K30.39038117
124BCKDK0.38920686
125AKT20.38905707
126CDK30.38148504
127MINK10.37989539
128ERBB40.37890983
129CDK140.37709031
130SYK0.37399526
131CASK0.37183809
132TAOK30.36463756
133TYK20.36084024
134PRKACB0.35939421
135ILK0.35447293
136GRK10.34231994
137CSNK1A10.34039887
138MAP3K60.33221334
139RPS6KA10.32892956
140CDK150.32586086
141LATS20.32575335
142STK390.31964501
143MAP3K50.31958053
144MAPK110.31609053
145INSRR0.31191991
146TXK0.30811961
147FGFR10.30692562
148DAPK10.30510368
149BLK0.30273516
150MAPKAPK50.29492506
151SIK30.28146464

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.01681821
2Mismatch repair_Homo sapiens_hsa034304.03693889
3Ribosome_Homo sapiens_hsa030104.00163092
4Spliceosome_Homo sapiens_hsa030403.34368323
5Base excision repair_Homo sapiens_hsa034103.24347434
6Homologous recombination_Homo sapiens_hsa034402.97643805
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.95217521
8RNA transport_Homo sapiens_hsa030132.91147822
9RNA polymerase_Homo sapiens_hsa030202.91132929
10Cell cycle_Homo sapiens_hsa041102.85299931
11Proteasome_Homo sapiens_hsa030502.84243488
12Nucleotide excision repair_Homo sapiens_hsa034202.59982169
13Pyrimidine metabolism_Homo sapiens_hsa002402.44719191
14Oxidative phosphorylation_Homo sapiens_hsa001902.30246730
15One carbon pool by folate_Homo sapiens_hsa006702.14401252
16RNA degradation_Homo sapiens_hsa030182.01801577
17Fanconi anemia pathway_Homo sapiens_hsa034601.95967357
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93276915
19Non-homologous end-joining_Homo sapiens_hsa034501.93178402
20mRNA surveillance pathway_Homo sapiens_hsa030151.81837004
21Basal transcription factors_Homo sapiens_hsa030221.73214802
22p53 signaling pathway_Homo sapiens_hsa041151.65676573
23Propanoate metabolism_Homo sapiens_hsa006401.57633295
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38437537
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37950796
26Fatty acid elongation_Homo sapiens_hsa000621.34808809
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30570503
28Epstein-Barr virus infection_Homo sapiens_hsa051691.29150311
29Herpes simplex infection_Homo sapiens_hsa051681.27162625
30Steroid biosynthesis_Homo sapiens_hsa001001.26693975
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23387870
32Sulfur relay system_Homo sapiens_hsa041221.21008113
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19507450
34Alzheimers disease_Homo sapiens_hsa050101.18920245
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18586738
36Systemic lupus erythematosus_Homo sapiens_hsa053221.15870109
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15759564
38Purine metabolism_Homo sapiens_hsa002301.13937451
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13334482
40Antigen processing and presentation_Homo sapiens_hsa046121.09866797
41Phototransduction_Homo sapiens_hsa047441.08372208
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08103893
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05517985
44Pyruvate metabolism_Homo sapiens_hsa006201.04489061
45Oocyte meiosis_Homo sapiens_hsa041141.02324062
46Butanoate metabolism_Homo sapiens_hsa006500.97875152
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95277524
48Viral carcinogenesis_Homo sapiens_hsa052030.94278631
49Primary immunodeficiency_Homo sapiens_hsa053400.93271780
50Protein export_Homo sapiens_hsa030600.90260094
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88357715
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86716090
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.85922145
54HTLV-I infection_Homo sapiens_hsa051660.84861556
55Folate biosynthesis_Homo sapiens_hsa007900.84690455
56Thyroid cancer_Homo sapiens_hsa052160.84415161
57Pentose phosphate pathway_Homo sapiens_hsa000300.83121399
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78241492
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77825498
60Colorectal cancer_Homo sapiens_hsa052100.75626178
61Legionellosis_Homo sapiens_hsa051340.75342268
62N-Glycan biosynthesis_Homo sapiens_hsa005100.71442930
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70902262
64Chronic myeloid leukemia_Homo sapiens_hsa052200.69682691
65Metabolic pathways_Homo sapiens_hsa011000.69217255
66Hepatitis B_Homo sapiens_hsa051610.65775787
67Peroxisome_Homo sapiens_hsa041460.65134243
68Apoptosis_Homo sapiens_hsa042100.64578463
69Measles_Homo sapiens_hsa051620.64559600
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64174748
71Acute myeloid leukemia_Homo sapiens_hsa052210.63788070
72Selenocompound metabolism_Homo sapiens_hsa004500.63156714
73MicroRNAs in cancer_Homo sapiens_hsa052060.62374856
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.61787818
75Shigellosis_Homo sapiens_hsa051310.60743722
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.60476222
77Renin-angiotensin system_Homo sapiens_hsa046140.60235391
78Cardiac muscle contraction_Homo sapiens_hsa042600.58175905
79Small cell lung cancer_Homo sapiens_hsa052220.57738318
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57536297
81Nicotine addiction_Homo sapiens_hsa050330.57167337
82Fatty acid metabolism_Homo sapiens_hsa012120.56864466
83B cell receptor signaling pathway_Homo sapiens_hsa046620.56494248
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56224155
85Notch signaling pathway_Homo sapiens_hsa043300.55555497
86Retinol metabolism_Homo sapiens_hsa008300.53667054
87Caffeine metabolism_Homo sapiens_hsa002320.53089439
88Taste transduction_Homo sapiens_hsa047420.52618192
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.52297891
90Biosynthesis of amino acids_Homo sapiens_hsa012300.52018608
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51173857
92Alcoholism_Homo sapiens_hsa050340.50969939
93Huntingtons disease_Homo sapiens_hsa050160.47764342
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47498612
95Leishmaniasis_Homo sapiens_hsa051400.45179404
96Pancreatic cancer_Homo sapiens_hsa052120.45132583
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44335903
98Influenza A_Homo sapiens_hsa051640.43946155
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42312026
100Sulfur metabolism_Homo sapiens_hsa009200.41707531
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41506704
102Arginine and proline metabolism_Homo sapiens_hsa003300.41410588
103Regulation of autophagy_Homo sapiens_hsa041400.41374367
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.40713717
105Bladder cancer_Homo sapiens_hsa052190.40216003
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39955251
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39266854
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.38747553
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38072788
110Non-small cell lung cancer_Homo sapiens_hsa052230.38068454
111Vitamin digestion and absorption_Homo sapiens_hsa049770.37185796
112mTOR signaling pathway_Homo sapiens_hsa041500.37080545
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36738510
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36521552
115TGF-beta signaling pathway_Homo sapiens_hsa043500.35540834
116Chemical carcinogenesis_Homo sapiens_hsa052040.35401714
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32671672
118HIF-1 signaling pathway_Homo sapiens_hsa040660.32481049
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32287498
120T cell receptor signaling pathway_Homo sapiens_hsa046600.31296759
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30889843
122Fatty acid degradation_Homo sapiens_hsa000710.30791466
123Hippo signaling pathway_Homo sapiens_hsa043900.30295982
124Hematopoietic cell lineage_Homo sapiens_hsa046400.29390430
125Viral myocarditis_Homo sapiens_hsa054160.28514541
126beta-Alanine metabolism_Homo sapiens_hsa004100.28513413
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28214556
128Olfactory transduction_Homo sapiens_hsa047400.27807134
129Basal cell carcinoma_Homo sapiens_hsa052170.27000695
130Maturity onset diabetes of the young_Homo sapiens_hsa049500.26570852
131Pathways in cancer_Homo sapiens_hsa052000.24424233
132Endometrial cancer_Homo sapiens_hsa052130.23200868
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.22618378
134Starch and sucrose metabolism_Homo sapiens_hsa005000.21305324
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.21044693
136Linoleic acid metabolism_Homo sapiens_hsa005910.20942793
137Wnt signaling pathway_Homo sapiens_hsa043100.19999413
138Intestinal immune network for IgA production_Homo sapiens_hsa046720.19627925
139Cyanoamino acid metabolism_Homo sapiens_hsa004600.19583401
140Tryptophan metabolism_Homo sapiens_hsa003800.18816053
141VEGF signaling pathway_Homo sapiens_hsa043700.18244772
142Hedgehog signaling pathway_Homo sapiens_hsa043400.18195772
143Glutathione metabolism_Homo sapiens_hsa004800.17790675
144Parkinsons disease_Homo sapiens_hsa050120.17572381
145Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17455108
146Prostate cancer_Homo sapiens_hsa052150.17063674
147Vitamin B6 metabolism_Homo sapiens_hsa007500.16491311
148Primary bile acid biosynthesis_Homo sapiens_hsa001200.15643544
149FoxO signaling pathway_Homo sapiens_hsa040680.15546336
150Carbon metabolism_Homo sapiens_hsa012000.14812981
151Toll-like receptor signaling pathway_Homo sapiens_hsa046200.13073408
152Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.12821890

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