YBX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.06355907
2DNA unwinding involved in DNA replication (GO:0006268)5.02130006
3nuclear pore organization (GO:0006999)5.00222547
4protein localization to kinetochore (GO:0034501)4.52922216
5mitotic nuclear envelope disassembly (GO:0007077)4.16174565
6heterochromatin organization (GO:0070828)4.14430425
7mitotic sister chromatid cohesion (GO:0007064)4.11854714
8DNA replication-dependent nucleosome assembly (GO:0006335)4.08635475
9DNA replication-dependent nucleosome organization (GO:0034723)4.08635475
10protein localization to chromosome, centromeric region (GO:0071459)4.08119618
11folic acid-containing compound biosynthetic process (GO:0009396)4.06463617
12nuclear envelope disassembly (GO:0051081)3.92099541
13membrane disassembly (GO:0030397)3.92099541
14pore complex assembly (GO:0046931)3.76871154
15formation of translation preinitiation complex (GO:0001731)3.75843880
16DNA replication initiation (GO:0006270)3.74064646
17regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.73457218
18establishment of integrated proviral latency (GO:0075713)3.72652896
19regulation of nucleobase-containing compound transport (GO:0032239)3.69385314
20DNA strand elongation involved in DNA replication (GO:0006271)3.67526204
21sister chromatid segregation (GO:0000819)3.65329593
22viral transcription (GO:0019083)3.58989403
23translational termination (GO:0006415)3.58248932
24protein complex localization (GO:0031503)3.57813177
25regulation of RNA export from nucleus (GO:0046831)3.55934277
26mitotic sister chromatid segregation (GO:0000070)3.55363037
27regulation of spindle organization (GO:0090224)3.55357873
28DNA duplex unwinding (GO:0032508)3.51029067
29pre-miRNA processing (GO:0031054)3.50934866
30mitotic metaphase plate congression (GO:0007080)3.50120004
31protein-DNA complex disassembly (GO:0032986)3.49334824
32nucleosome disassembly (GO:0006337)3.49334824
33DNA geometric change (GO:0032392)3.49220556
34regulation of translational fidelity (GO:0006450)3.48102453
35negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.47074859
36DNA strand elongation (GO:0022616)3.44008211
37mitotic chromosome condensation (GO:0007076)3.43521443
38ribosome assembly (GO:0042255)3.40113352
39IMP biosynthetic process (GO:0006188)3.39537617
40regulation of histone H3-K9 methylation (GO:0051570)3.38953378
41cellular protein complex localization (GO:0034629)3.38568191
42regulation of mitotic spindle organization (GO:0060236)3.37124860
43regulation of NFAT protein import into nucleus (GO:0051532)3.36279835
44maturation of SSU-rRNA (GO:0030490)3.34221079
45negative regulation of RNA splicing (GO:0033119)3.32791461
46regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.32558977
47translational initiation (GO:0006413)3.32504202
48chromatin assembly (GO:0031497)3.31251276
49regulation of mammary gland epithelial cell proliferation (GO:0033599)3.30130077
50nucleobase-containing small molecule interconversion (GO:0015949)3.29822408
51nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.29751369
52protein export from nucleus (GO:0006611)3.28531565
53translational elongation (GO:0006414)3.24495211
54Golgi transport vesicle coating (GO:0048200)3.19242516
55COPI coating of Golgi vesicle (GO:0048205)3.19242516
56regulation of posttranscriptional gene silencing (GO:0060147)3.18689116
57regulation of gene silencing by miRNA (GO:0060964)3.18689116
58regulation of gene silencing by RNA (GO:0060966)3.18689116
59positive regulation of chromosome segregation (GO:0051984)3.18280765
60nuclear envelope organization (GO:0006998)3.16161434
61kinetochore organization (GO:0051383)3.15103560
62histone H2B ubiquitination (GO:0033523)3.14646090
63IMP metabolic process (GO:0046040)3.13334303
64translesion synthesis (GO:0019985)3.10941302
65dosage compensation (GO:0007549)3.07674809
66negative regulation of histone methylation (GO:0031061)3.07409269
67metaphase plate congression (GO:0051310)3.06245456
68chromatin assembly or disassembly (GO:0006333)3.06016619
69negative regulation of mRNA processing (GO:0050686)3.03377692
70telomere maintenance via semi-conservative replication (GO:0032201)3.02034870
71ribosomal large subunit biogenesis (GO:0042273)3.01962103
72* RNA stabilization (GO:0043489)2.99875046
73* mRNA stabilization (GO:0048255)2.99875046
74regulation of sister chromatid cohesion (GO:0007063)2.98908606
75regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.98345351
76protein localization to chromosome (GO:0034502)2.98327646
77chaperone-mediated protein complex assembly (GO:0051131)2.98141535
78chromosome condensation (GO:0030261)2.98089118
79ribosomal small subunit assembly (GO:0000028)2.97704856
80ribonucleoprotein complex biogenesis (GO:0022613)2.96590484
81DNA conformation change (GO:0071103)2.96463757
82negative regulation of mRNA metabolic process (GO:1903312)2.96124568
83regulation of chromosome segregation (GO:0051983)2.95400844
84nucleobase biosynthetic process (GO:0046112)2.94976578
85planar cell polarity pathway involved in neural tube closure (GO:0090179)2.94821969
86proline biosynthetic process (GO:0006561)2.94379479
87regulation of translational termination (GO:0006449)2.93705621
88ribosomal small subunit biogenesis (GO:0042274)2.92899265
89DNA replication checkpoint (GO:0000076)2.92224971
90mitotic recombination (GO:0006312)2.90192662
91regulation of centrosome cycle (GO:0046605)2.88912478
92cellular protein complex disassembly (GO:0043624)2.87387516
93DNA replication-independent nucleosome assembly (GO:0006336)2.86761775
94DNA replication-independent nucleosome organization (GO:0034724)2.86761775
953-UTR-mediated mRNA stabilization (GO:0070935)2.85795898
96peptidyl-arginine omega-N-methylation (GO:0035247)2.84744611
97DNA packaging (GO:0006323)2.83093504
98positive regulation of mitotic sister chromatid separation (GO:1901970)2.82882649
99positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.82882649
100positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.82882649
101alternative mRNA splicing, via spliceosome (GO:0000380)2.82860229
102* regulation of mRNA stability (GO:0043488)2.81779832
103chromatin remodeling at centromere (GO:0031055)2.81748042
104protein complex disassembly (GO:0043241)2.79935102
105histone H2A monoubiquitination (GO:0035518)2.79745322
106regulation of early endosome to late endosome transport (GO:2000641)2.79652754
107telomere maintenance via recombination (GO:0000722)2.78049276
108pentose-phosphate shunt (GO:0006098)2.77628078
109paraxial mesoderm development (GO:0048339)2.77075075
110protein localization to microtubule (GO:0035372)2.76786438
111cellular hyperosmotic response (GO:0071474)2.76236262
112ATP-dependent chromatin remodeling (GO:0043044)2.75883048
113positive regulation of SMAD protein import into nucleus (GO:0060391)2.75287192
114viral life cycle (GO:0019058)2.74622398
115* mRNA splicing, via spliceosome (GO:0000398)2.73959154
116* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.73959154
117DNA topological change (GO:0006265)2.73875102
118* RNA splicing, via transesterification reactions (GO:0000375)2.72210590
119establishment of chromosome localization (GO:0051303)2.71596556
120negative regulation of DNA repair (GO:0045738)2.71319893
121negative regulation of chromosome segregation (GO:0051985)2.70436749
122regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.70161875
123spliceosomal tri-snRNP complex assembly (GO:0000244)2.70018578
124glucocorticoid receptor signaling pathway (GO:0042921)2.68363781
125establishment of viral latency (GO:0019043)2.66737527
126ribosome biogenesis (GO:0042254)2.66165105
127positive regulation of DNA-dependent DNA replication (GO:2000105)2.65072381
128positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.63884424
129mRNA transport (GO:0051028)2.61827320
130* regulation of RNA stability (GO:0043487)2.60238520
131maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.60098933
132protein retention in ER lumen (GO:0006621)2.58498433
133peptidyl-arginine N-methylation (GO:0035246)2.54943844
134peptidyl-arginine methylation (GO:0018216)2.54943844
135positive regulation of DNA-templated transcription, elongation (GO:0032786)2.54412556
136histone arginine methylation (GO:0034969)2.54059495
137regulation of glucose import in response to insulin stimulus (GO:2001273)2.53618950

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.11589427
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.14287866
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.98090996
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.66341113
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.53310885
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.15903338
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.05277109
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.96569658
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.91300796
10AR_21909140_ChIP-Seq_LNCAP_Human2.54621592
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46503464
12* MYC_22102868_ChIP-Seq_BL_Human2.44375686
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.17705639
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.16869489
15* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15936831
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.15079429
17* XRN2_22483619_ChIP-Seq_HELA_Human2.12690281
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.08301743
19* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82076542
20CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79053071
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.72334568
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.69958579
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69464295
24STAT3_1855785_ChIP-Seq_MESCs_Mouse1.62261905
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.61614837
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59764610
27ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59583790
28* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57852381
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56509100
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56010261
31TTF2_22483619_ChIP-Seq_HELA_Human1.50387144
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47864221
33KLF4_18555785_ChIP-Seq_MESCs_Mouse1.46089937
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45455764
35KDM5A_27292631_Chip-Seq_BREAST_Human1.45215029
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43856073
37* VDR_21846776_ChIP-Seq_THP-1_Human1.43624058
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42752043
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42537138
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42263668
41* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40207117
42DCP1A_22483619_ChIP-Seq_HELA_Human1.40143249
43VDR_23849224_ChIP-Seq_CD4+_Human1.39874733
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39311372
45TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36613215
46CIITA_25753668_ChIP-Seq_RAJI_Human1.36081623
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.34825728
48* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33488844
49* RACK7_27058665_Chip-Seq_MCF-7_Human1.32602536
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.32377245
51GABP_19822575_ChIP-Seq_HepG2_Human1.31821827
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31719534
53FOXP3_21729870_ChIP-Seq_TREG_Human1.31249978
54LXR_22292898_ChIP-Seq_THP-1_Human1.30072079
55ZNF263_19887448_ChIP-Seq_K562_Human1.28524643
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28279640
57* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.27660054
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26033671
59* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25681022
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25635741
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25291393
62HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24439302
63* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23996426
64NCOR1_26117541_ChIP-Seq_K562_Human1.22931825
65* GABP_17652178_ChIP-ChIP_JURKAT_Human1.22677642
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21544580
67KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21483997
68* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20980558
69PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20129055
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19126816
71CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18841552
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18758066
73ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.15050848
74TCF3_18692474_ChIP-Seq_MEFs_Mouse1.14927502
75HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14345893
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13902824
77JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.13360796
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11345055
79* ELK1_19687146_ChIP-ChIP_HELA_Human1.11054830
80TFEB_21752829_ChIP-Seq_HELA_Human1.10134419
81NANOG_21062744_ChIP-ChIP_HESCs_Human1.09820468
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08351430
83TCF7_22412390_ChIP-Seq_EML_Mouse1.08044375
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07681133
85KDM2B_26808549_Chip-Seq_K562_Human1.06788605
86CHD1_26751641_Chip-Seq_LNCaP_Human1.06097306
87SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06092078
88ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05974680
89* KDM2B_26808549_Chip-Seq_JURKAT_Human1.04567529
90ATF3_27146783_Chip-Seq_COLON_Human1.04544967
91ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04307011
92EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04171024
93* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03966043
94RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01953161
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00477423
96* ELK3_25401928_ChIP-Seq_HUVEC_Human0.99124317
97* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98999519
98SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97936465
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97746561
100THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97486878
101CLOCK_20551151_ChIP-Seq_293T_Human0.97104917
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96622315
103DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96320709
104CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96214582
105TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96041206
106TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95376773
107TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.95194393
108BRD4_27068464_Chip-Seq_AML-cells_Mouse0.95095074
109HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93509466
110TP63_17297297_ChIP-ChIP_HaCaT_Human0.92933373
111SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92770196
112* UTX_26944678_Chip-Seq_JUKART_Human0.91935056
113ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91667324
114HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91041707
115CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90735582
116* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90715963
117* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90433770
118* KDM2B_26808549_Chip-Seq_DND41_Human0.90112468
119HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89904411
120PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88501759
121NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.85459909
122STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.85384775
123NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.85002812
124NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84885560
125STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84082793
126MAF_26560356_Chip-Seq_TH1_Human0.84045249

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.64755742
2MP0004957_abnormal_blastocyst_morpholog3.47483437
3MP0003111_abnormal_nucleus_morphology3.41518305
4MP0010094_abnormal_chromosome_stability3.31712378
5MP0010352_gastrointestinal_tract_polyps3.08764957
6MP0003077_abnormal_cell_cycle3.05212163
7MP0003705_abnormal_hypodermis_morpholog2.91865787
8MP0005076_abnormal_cell_differentiation2.55094308
9MP0001730_embryonic_growth_arrest2.50025178
10MP0005451_abnormal_body_composition2.47102859
11MP0008057_abnormal_DNA_replication2.45410915
12MP0008007_abnormal_cellular_replicative2.25065615
13MP0010307_abnormal_tumor_latency2.16537008
14MP0000537_abnormal_urethra_morphology2.07974011
15* MP0000350_abnormal_cell_proliferation2.07153267
16MP0003123_paternal_imprinting2.03070108
17MP0008932_abnormal_embryonic_tissue2.00565551
18MP0002084_abnormal_developmental_patter1.85740591
19* MP0001672_abnormal_embryogenesis/_devel1.85408419
20* MP0005380_embryogenesis_phenotype1.85408419
21* MP0004197_abnormal_fetal_growth/weight/1.82349006
22MP0003567_abnormal_fetal_cardiomyocyte1.82167692
23* MP0001697_abnormal_embryo_size1.80717651
24* MP0003984_embryonic_growth_retardation1.76514259
25MP0008058_abnormal_DNA_repair1.76130194
26* MP0002088_abnormal_embryonic_growth/wei1.74793885
27MP0002396_abnormal_hematopoietic_system1.74684204
28* MP0002085_abnormal_embryonic_tissue1.73362074
29MP0009053_abnormal_anal_canal1.67859269
30MP0002086_abnormal_extraembryonic_tissu1.66508422
31* MP0002080_prenatal_lethality1.62673430
32MP0004858_abnormal_nervous_system1.61362927
33MP0003566_abnormal_cell_adhesion1.59245514
34MP0000733_abnormal_muscle_development1.57635119
35MP0010030_abnormal_orbit_morphology1.56308908
36MP0002009_preneoplasia1.50684959
37MP0006054_spinal_hemorrhage1.47494731
38MP0000490_abnormal_crypts_of1.43579007
39MP0005623_abnormal_meninges_morphology1.43474504
40MP0004808_abnormal_hematopoietic_stem1.41642638
41MP0005257_abnormal_intraocular_pressure1.38558299
42MP0001293_anophthalmia1.32060858
43MP0009379_abnormal_foot_pigmentation1.31659867
44MP0001849_ear_inflammation1.31555855
45MP0009278_abnormal_bone_marrow1.28195164
46MP0003453_abnormal_keratinocyte_physiol1.27926219
47MP0010234_abnormal_vibrissa_follicle1.23841449
48MP0003221_abnormal_cardiomyocyte_apopto1.23230062
49MP0000678_abnormal_parathyroid_gland1.22596826
50MP0008438_abnormal_cutaneous_collagen1.19022284
51MP0000747_muscle_weakness1.18804507
52MP0000313_abnormal_cell_death1.18204234
53MP0004233_abnormal_muscle_weight1.16652180
54MP0009672_abnormal_birth_weight1.10562954
55MP0005409_darkened_coat_color1.10561569
56MP0003315_abnormal_perineum_morphology1.09584136
57MP0000750_abnormal_muscle_regeneration1.09161879
58MP0002019_abnormal_tumor_incidence1.08895197
59MP0002796_impaired_skin_barrier1.08668625
60MP0008877_abnormal_DNA_methylation1.08530024
61MP0003890_abnormal_embryonic-extraembry1.08415456
62MP0003119_abnormal_digestive_system1.07931907
63MP0004185_abnormal_adipocyte_glucose1.06018815
64MP0002697_abnormal_eye_size1.04453613
65MP0005023_abnormal_wound_healing1.04221255
66MP0000759_abnormal_skeletal_muscle1.03692698
67MP0003121_genomic_imprinting1.03616268
68MP0002092_abnormal_eye_morphology1.03389019
69MP0005375_adipose_tissue_phenotype1.03029194
70MP0004084_abnormal_cardiac_muscle1.01553717
71MP0010630_abnormal_cardiac_muscle1.00657637
72MP0008260_abnormal_autophagy1.00500082
73MP0001661_extended_life_span1.00332581
74MP0009703_decreased_birth_body1.00331027
75MP0001545_abnormal_hematopoietic_system0.99047167
76MP0005397_hematopoietic_system_phenotyp0.99047167
77MP0003115_abnormal_respiratory_system0.98711657
78MP0003656_abnormal_erythrocyte_physiolo0.98086110
79MP0003303_peritoneal_inflammation0.97577317
80MP0002925_abnormal_cardiovascular_devel0.96720587
81MP0002877_abnormal_melanocyte_morpholog0.96542313
82MP0003300_gastrointestinal_ulcer0.95133689
83MP0003937_abnormal_limbs/digits/tail_de0.94976443
84MP0002653_abnormal_ependyma_morphology0.94587852
85MP0002060_abnormal_skin_morphology0.92533512
86MP0003786_premature_aging0.91324678
87* MP0000428_abnormal_craniofacial_morphol0.91111343
88MP0003942_abnormal_urinary_system0.89030002
89MP0000003_abnormal_adipose_tissue0.88932263
90MP0002111_abnormal_tail_morphology0.88257881
91MP0005058_abnormal_lysosome_morphology0.86911550
92MP0002210_abnormal_sex_determination0.86748017
93* MP0001915_intracranial_hemorrhage0.85364351
94MP0000266_abnormal_heart_morphology0.85168956
95MP0000432_abnormal_head_morphology0.82921871
96MP0000703_abnormal_thymus_morphology0.82699917
97MP0002282_abnormal_trachea_morphology0.82344797
98MP0001145_abnormal_male_reproductive0.82205821
99MP0003935_abnormal_craniofacial_develop0.81323408
100MP0002089_abnormal_postnatal_growth/wei0.81071078
101MP0002249_abnormal_larynx_morphology0.80428663
102MP0002269_muscular_atrophy0.80136171
103MP0003941_abnormal_skin_development0.79863364
104MP0004087_abnormal_muscle_fiber0.78345785
105MP0001929_abnormal_gametogenesis0.77763973
106MP0008770_decreased_survivor_rate0.77365924
107MP0003385_abnormal_body_wall0.76675200
108MP0000762_abnormal_tongue_morphology0.76107086
109MP0000858_altered_metastatic_potential0.75969853
110MP0009333_abnormal_splenocyte_physiolog0.74809157
111MP0002114_abnormal_axial_skeleton0.74350637
112MP0000477_abnormal_intestine_morphology0.73993674
113MP0001727_abnormal_embryo_implantation0.72480442
114MP0005666_abnormal_adipose_tissue0.71874726
115MP0003448_altered_tumor_morphology0.70821063
116MP0005621_abnormal_cell_physiology0.68818668
117MP0001216_abnormal_epidermal_layer0.67742873
118MP0001348_abnormal_lacrimal_gland0.67494185
119MP0001286_abnormal_eye_development0.66715777
120MP0003091_abnormal_cell_migration0.66572700
121MP0009697_abnormal_copulation0.66193870
122MP0004272_abnormal_basement_membrane0.66118474
123MP0005275_abnormal_skin_tensile0.66079254
124MP0005501_abnormal_skin_physiology0.65464790
125* MP0005384_cellular_phenotype0.64418089
126* MP0003861_abnormal_nervous_system0.63269646
127MP0002932_abnormal_joint_morphology0.62944119
128MP0003755_abnormal_palate_morphology0.62714474

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.65213891
2Selective tooth agenesis (HP:0001592)3.46196701
3Reticulocytopenia (HP:0001896)3.26543491
4Proximal placement of thumb (HP:0009623)3.09666186
5Deviation of the thumb (HP:0009603)3.07713973
6Colon cancer (HP:0003003)3.01882303
7Insomnia (HP:0100785)3.00497237
8Increased nuchal translucency (HP:0010880)2.95019255
9Abnormality of the astrocytes (HP:0100707)2.89371783
10Astrocytoma (HP:0009592)2.89371783
11Short 4th metacarpal (HP:0010044)2.86085874
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.86085874
13Asymmetry of the thorax (HP:0001555)2.85713630
14Increased density of long bones (HP:0006392)2.83498018
15Medulloblastoma (HP:0002885)2.73350339
16Abnormality of cells of the erythroid lineage (HP:0012130)2.68950323
17Volvulus (HP:0002580)2.59082705
18Progressive muscle weakness (HP:0003323)2.54195675
19Centrally nucleated skeletal muscle fibers (HP:0003687)2.52661980
20Hyperacusis (HP:0010780)2.52235091
21Achilles tendon contracture (HP:0001771)2.52113395
22Protrusio acetabuli (HP:0003179)2.47576661
23High pitched voice (HP:0001620)2.46780343
24Shallow orbits (HP:0000586)2.43799448
25Ankle contracture (HP:0006466)2.41163826
26Abnormal number of erythroid precursors (HP:0012131)2.39057997
27Missing ribs (HP:0000921)2.38811674
28Ankyloglossia (HP:0010296)2.37529285
29Biliary tract neoplasm (HP:0100574)2.36683585
30Distal lower limb amyotrophy (HP:0008944)2.35840238
31Disproportionate tall stature (HP:0001519)2.35720655
32Birth length less than 3rd percentile (HP:0003561)2.35556770
33Dysmetric saccades (HP:0000641)2.33409833
34Rhabdomyosarcoma (HP:0002859)2.33023137
35Overriding aorta (HP:0002623)2.32632894
36Calcaneovalgus deformity (HP:0001848)2.32416338
37Atresia of the external auditory canal (HP:0000413)2.30938937
38Abnormality of the anterior horn cell (HP:0006802)2.30551208
39Degeneration of anterior horn cells (HP:0002398)2.30551208
40Rectal prolapse (HP:0002035)2.29091342
41Multiple enchondromatosis (HP:0005701)2.28420511
42Termporal pattern (HP:0011008)2.28247050
43Insidious onset (HP:0003587)2.28247050
44Glioma (HP:0009733)2.24159351
45Abnormality of the 4th metacarpal (HP:0010012)2.24104956
46Renal duplication (HP:0000075)2.22842779
47Progressive external ophthalmoplegia (HP:0000590)2.22666794
48Basal cell carcinoma (HP:0002671)2.22243594
49Pelvic girdle muscle weakness (HP:0003749)2.21898758
50Angiofibromas (HP:0010615)2.20826914
51Adenoma sebaceum (HP:0009720)2.20826914
52Gastrointestinal carcinoma (HP:0002672)2.18174467
53Malignant gastrointestinal tract tumors (HP:0006749)2.18174467
54Orthostatic hypotension (HP:0001278)2.15101310
55Elfin facies (HP:0004428)2.14053740
56Abnormality of the Achilles tendon (HP:0005109)2.12997363
57Abnormal number of incisors (HP:0011064)2.11484128
58Genu recurvatum (HP:0002816)2.10931821
59Deep palmar crease (HP:0006191)2.09003950
60Patellar dislocation (HP:0002999)2.08858914
61High anterior hairline (HP:0009890)2.07655503
62Neoplasm of the pancreas (HP:0002894)2.06857902
63Patellar aplasia (HP:0006443)2.05329759
64Subacute progressive viral hepatitis (HP:0006572)2.05097599
65Long palpebral fissure (HP:0000637)2.04327755
66Abnormality of the calcaneus (HP:0008364)2.02726010
67Syringomyelia (HP:0003396)2.01321406
68Spinal cord lesions (HP:0100561)2.01321406
69Aplasia/hypoplasia of the humerus (HP:0006507)2.00413612
70Facial hemangioma (HP:0000329)1.98882678
71Breast hypoplasia (HP:0003187)1.98817795
72Neoplasm of the oral cavity (HP:0100649)1.98662365
73Prominent nose (HP:0000448)1.98506020
74Neoplasm of striated muscle (HP:0009728)1.98039409
75Agnosia (HP:0010524)1.97228347
76Overlapping toe (HP:0001845)1.96751787
77Abnormality of chromosome stability (HP:0003220)1.95123237
78Abnormality of abdominal situs (HP:0011620)1.94877151
79Abdominal situs inversus (HP:0003363)1.94877151
80Trismus (HP:0000211)1.94748949
81Aplasia/Hypoplasia of the patella (HP:0006498)1.94427056
82Increased connective tissue (HP:0009025)1.93431258
83Abnormality of oral frenula (HP:0000190)1.92717196
84Deformed tarsal bones (HP:0008119)1.92093585
85Uterine neoplasm (HP:0010784)1.91309831
86Fibroma (HP:0010614)1.91138028
87Difficulty climbing stairs (HP:0003551)1.90413907
88Lower limb amyotrophy (HP:0007210)1.90325729
89Impulsivity (HP:0100710)1.90223804
90Short humerus (HP:0005792)1.90105435
91Fibrous tissue neoplasm (HP:0012316)1.89467443
92Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86567265
93Pointed chin (HP:0000307)1.85992084
94Deep philtrum (HP:0002002)1.85545828
95Wrist flexion contracture (HP:0001239)1.85262702
96Back pain (HP:0003418)1.84738865
97Vertebral arch anomaly (HP:0008438)1.84395229
98Cortical dysplasia (HP:0002539)1.83620524
99Slender long bone (HP:0003100)1.83546718
100Macrocytic anemia (HP:0001972)1.83223831
101Ovarian neoplasm (HP:0100615)1.83110873
102Abnormality of skeletal muscle fiber size (HP:0012084)1.82632890
103Heterotopia (HP:0002282)1.82487661
104Abnormality of the distal phalanx of the thumb (HP:0009617)1.82431095
105Intestinal polyp (HP:0005266)1.81867089
106Shoulder girdle muscle weakness (HP:0003547)1.81191487
107Cutis marmorata (HP:0000965)1.80869461
108Abnormality of the hip-girdle musculature (HP:0001445)1.80727286
109Abnormality of the musculature of the pelvis (HP:0001469)1.80727286
110Abnormality of the phalanges of the hallux (HP:0010057)1.80643311
111Cutaneous melanoma (HP:0012056)1.80341388
112Long eyelashes (HP:0000527)1.80230457
113Squamous cell carcinoma (HP:0002860)1.79548660
114Pallor (HP:0000980)1.78963003
115Abnormality of reticulocytes (HP:0004312)1.78208668
116Thin ribs (HP:0000883)1.78093826
117Arnold-Chiari malformation (HP:0002308)1.77769731
118Atrophy/Degeneration involving motor neurons (HP:0007373)1.77668741
119Vertebral compression fractures (HP:0002953)1.77591218
120Abnormality of the left ventricular outflow tract (HP:0011103)1.76453725
121Subaortic stenosis (HP:0001682)1.76453725
122Neoplasm of the rectum (HP:0100743)1.76378094
123Reticulocytosis (HP:0001923)1.76205373
124Aplasia/Hypoplasia of the sternum (HP:0006714)1.75967377
125Skull defect (HP:0001362)1.75714769
126Chromsome breakage (HP:0040012)1.75615641
127Abnormality of the labia minora (HP:0012880)1.75544832
128Intestinal polyposis (HP:0200008)1.74971918
129Cafe-au-lait spot (HP:0000957)1.73987610
130Spastic diplegia (HP:0001264)1.73966384
131Neoplasm of the small intestine (HP:0100833)1.73729696
132Oral leukoplakia (HP:0002745)1.72939715
133Osteolytic defects of the phalanges of the hand (HP:0009771)1.72513352
134Osteolytic defects of the hand bones (HP:0009699)1.72513352
135Bicuspid aortic valve (HP:0001647)1.72121950
136Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.72108396
13711 pairs of ribs (HP:0000878)1.71847941
138Breech presentation (HP:0001623)1.71725517
139Premature rupture of membranes (HP:0001788)1.70630486
140Bowel diverticulosis (HP:0005222)1.70246100
141Renovascular hypertension (HP:0100817)1.69214902
142Abnormality of the tricuspid valve (HP:0001702)1.68021863
143Flat cornea (HP:0007720)1.67854749
144Turricephaly (HP:0000262)1.67143756
145Absent thumb (HP:0009777)1.66920180
146Abnormality of the thoracic spine (HP:0100711)1.66590447
147Ulnar bowing (HP:0003031)1.66498723
148Abnormality of the umbilical cord (HP:0010881)1.66398016
149Increased variability in muscle fiber diameter (HP:0003557)1.66186059
150Bladder diverticulum (HP:0000015)1.65791702
151Hypercalcemia (HP:0003072)1.65513834
152Broad distal phalanx of finger (HP:0009836)1.65404196
153Cerebral aneurysm (HP:0004944)1.64788854
154Pseudobulbar signs (HP:0002200)1.64364289
155Leiomyosarcoma (HP:0100243)1.63830915
156Uterine leiomyosarcoma (HP:0002891)1.63830915
157Ragged-red muscle fibers (HP:0003200)1.63667431
158Unilateral renal agenesis (HP:0000122)1.61735540
159Abnormal gallbladder physiology (HP:0012438)1.60344633
160Cholecystitis (HP:0001082)1.60344633
161Spinal rigidity (HP:0003306)1.59535694
162Bowel incontinence (HP:0002607)1.59193563
163Flat acetabular roof (HP:0003180)1.58624446
164Flared metaphyses (HP:0003015)1.58285244
165Glossoptosis (HP:0000162)1.58032177
166Mitral regurgitation (HP:0001653)1.57802212
167Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.56841630
168Truncus arteriosus (HP:0001660)1.56359467
169Abnormal large intestine physiology (HP:0012700)1.56035647
170Abnormality of the distal phalanges of the toes (HP:0010182)1.54654878
171Obsessive-compulsive behavior (HP:0000722)1.53815946
172Natal tooth (HP:0000695)1.53522314

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.91846355
2EEF2K3.18276835
3SMG13.09799644
4NEK23.05511409
5PKN22.96167644
6CDK122.77893313
7WEE12.68584377
8NEK12.59215653
9TRIB32.56325530
10MAP3K102.42872769
11PRPF4B2.31712966
12IRAK32.25647986
13BUB12.14064534
14SCYL22.08774188
15TTK1.98957526
16TTN1.93062129
17RPS6KB21.82822304
18TESK21.80590465
19PDK31.73346272
20PDK41.73346272
21STK101.58842169
22PASK1.58336285
23TESK11.57876340
24LRRK21.53622836
25TSSK61.51280589
26PAK41.50006419
27RPS6KA41.49505163
28CDK41.49427997
29EPHA21.46041010
30MAP3K81.45424649
31AURKB1.42411531
32TGFBR11.38830275
33DYRK31.36526712
34SRPK11.34320641
35ATR1.32775220
36PLK11.32670950
37CDK71.31558621
38CDK61.30744862
39NME21.30493407
40ALK1.29453318
41MKNK11.28771859
42SIK11.27277775
43ICK1.23213889
44STK31.22572202
45EIF2AK11.21196942
46ACVR1B1.18131153
47MTOR1.16958585
48PBK1.15693621
49LATS11.14390907
50* CHEK11.14144794
51PAK21.13267723
52KSR21.13091653
53CHEK21.11402432
54NTRK11.04868810
55PTK61.02687594
56FGFR40.99903456
57LATS20.98733810
58CLK10.97565587
59STK40.95805629
60ILK0.93750629
61BRAF0.93392225
62PLK30.93099168
63BRSK20.92002499
64PDGFRA0.90164358
65PNCK0.88264168
66ATM0.88056718
67MOS0.85682350
68CAMK1G0.85222491
69TAOK20.84843811
70CDK20.84720238
71AURKA0.84311366
72BRD40.83561669
73PDK20.82093197
74MAP3K130.81150160
75TLK10.77566578
76BMX0.76554243
77RIPK10.76407466
78PIM10.71951585
79MAP3K90.71856722
80ARAF0.71444269
81FLT30.70403226
82KDR0.66572474
83MKNK20.64906048
84DMPK0.64738418
85FGFR10.64595172
86PAK10.63659208
87KSR10.62910073
88CDK80.60422391
89DYRK1B0.59787325
90AKT20.58560716
91CDK10.57609328
92TYRO30.56768412
93TAF10.56454970
94CSNK2A20.56303153
95CDK11A0.55796999
96CSNK1E0.53987050
97CDK150.51096974
98CSNK1D0.50799158
99IRAK20.50306830
100MST1R0.50092590
101CAMK1D0.49525972
102LIMK10.48806887
103MAP3K140.48512216
104CDK180.45666753
105EPHB20.45660807
106MAP2K30.43235724
107RAF10.42931105
108MAPK110.42086823
109RPS6KC10.42014961
110RPS6KL10.42014961
111EIF2AK30.41399887
112CDK140.41396178
113PRKDC0.41348858
114ERBB40.41081097
115ERN10.39946326
116PLK40.39940400
117MELK0.39679133
118MAPKAPK30.37089112
119MAP4K10.36888148
120BRSK10.35393782
121SIK20.35274615
122CSNK2A10.34562781
123MAP3K60.34192783
124PDGFRB0.33668480
125PRKCI0.29597090
126MET0.28983571
127MAPK140.28919766
128DDR20.25652160
129PIM20.25554523
130VRK10.24806318
131MAPK10.23538671
132PTK20.23224235
133CDK90.22572717
134* RPS6KA10.21737360
135* AKT10.21661495

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.09963261
2Mismatch repair_Homo sapiens_hsa034303.33730896
3Spliceosome_Homo sapiens_hsa030403.24648171
4RNA transport_Homo sapiens_hsa030133.19391682
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.96472066
6Cell cycle_Homo sapiens_hsa041102.76256185
7One carbon pool by folate_Homo sapiens_hsa006702.63762159
8Ribosome_Homo sapiens_hsa030102.60330448
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.52199389
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.28170833
11Nucleotide excision repair_Homo sapiens_hsa034202.21499008
12Base excision repair_Homo sapiens_hsa034102.15191855
13mRNA surveillance pathway_Homo sapiens_hsa030152.14836365
14Homologous recombination_Homo sapiens_hsa034402.00460217
15p53 signaling pathway_Homo sapiens_hsa041151.69845718
16RNA degradation_Homo sapiens_hsa030181.54239210
17Fanconi anemia pathway_Homo sapiens_hsa034601.53211788
18Systemic lupus erythematosus_Homo sapiens_hsa053221.50286257
19RNA polymerase_Homo sapiens_hsa030201.49679214
20Viral carcinogenesis_Homo sapiens_hsa052031.45399517
21Pyrimidine metabolism_Homo sapiens_hsa002401.39741194
22Non-homologous end-joining_Homo sapiens_hsa034501.39466282
23Proteasome_Homo sapiens_hsa030501.37604941
24Small cell lung cancer_Homo sapiens_hsa052221.37383784
25MicroRNAs in cancer_Homo sapiens_hsa052061.37141737
26Antigen processing and presentation_Homo sapiens_hsa046121.30944590
27Viral myocarditis_Homo sapiens_hsa054161.29216505
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.28446263
29Chronic myeloid leukemia_Homo sapiens_hsa052201.21670589
30Adherens junction_Homo sapiens_hsa045201.19503405
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18456436
32HTLV-I infection_Homo sapiens_hsa051661.15022982
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11049283
34Prion diseases_Homo sapiens_hsa050201.10154279
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09722440
36Epstein-Barr virus infection_Homo sapiens_hsa051691.08299260
37Basal transcription factors_Homo sapiens_hsa030221.07570077
38Colorectal cancer_Homo sapiens_hsa052101.07271967
39Hippo signaling pathway_Homo sapiens_hsa043901.04632941
40Oocyte meiosis_Homo sapiens_hsa041141.03039333
41ErbB signaling pathway_Homo sapiens_hsa040121.02083373
42Insulin signaling pathway_Homo sapiens_hsa049101.00679323
43Selenocompound metabolism_Homo sapiens_hsa004500.99032584
44Basal cell carcinoma_Homo sapiens_hsa052170.98123142
45Thyroid cancer_Homo sapiens_hsa052160.97980191
46Central carbon metabolism in cancer_Homo sapiens_hsa052300.97117029
47Biosynthesis of amino acids_Homo sapiens_hsa012300.96870455
48Bladder cancer_Homo sapiens_hsa052190.96295021
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96126322
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95222452
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93780892
52Pentose phosphate pathway_Homo sapiens_hsa000300.91643231
53mTOR signaling pathway_Homo sapiens_hsa041500.88444506
54Proteoglycans in cancer_Homo sapiens_hsa052050.88375764
55Galactose metabolism_Homo sapiens_hsa000520.88312625
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86405351
57Herpes simplex infection_Homo sapiens_hsa051680.85824757
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84897642
59Carbon metabolism_Homo sapiens_hsa012000.83344652
60Notch signaling pathway_Homo sapiens_hsa043300.82507418
61Fructose and mannose metabolism_Homo sapiens_hsa000510.81136114
62Lysine degradation_Homo sapiens_hsa003100.80075177
63TGF-beta signaling pathway_Homo sapiens_hsa043500.79492655
64Focal adhesion_Homo sapiens_hsa045100.78900101
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77714256
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76875840
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74667557
68Tight junction_Homo sapiens_hsa045300.72064117
69Endometrial cancer_Homo sapiens_hsa052130.71652185
70Legionellosis_Homo sapiens_hsa051340.71167253
71Apoptosis_Homo sapiens_hsa042100.69281094
72Hedgehog signaling pathway_Homo sapiens_hsa043400.68583055
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68362713
74HIF-1 signaling pathway_Homo sapiens_hsa040660.67827679
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.65383682
76Shigellosis_Homo sapiens_hsa051310.64992421
77Pancreatic cancer_Homo sapiens_hsa052120.64463778
78Pathways in cancer_Homo sapiens_hsa052000.64366220
79Acute myeloid leukemia_Homo sapiens_hsa052210.62723586
80Prostate cancer_Homo sapiens_hsa052150.62024316
81Prolactin signaling pathway_Homo sapiens_hsa049170.61538808
82Non-small cell lung cancer_Homo sapiens_hsa052230.60447486
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.60120786
84Renal cell carcinoma_Homo sapiens_hsa052110.59525819
85Hepatitis B_Homo sapiens_hsa051610.58783175
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.58355205
87Other glycan degradation_Homo sapiens_hsa005110.57582852
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55519635
89ECM-receptor interaction_Homo sapiens_hsa045120.55392688
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53727810
91AMPK signaling pathway_Homo sapiens_hsa041520.53052800
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52150520
93Estrogen signaling pathway_Homo sapiens_hsa049150.51890543
94Alcoholism_Homo sapiens_hsa050340.51060592
95Pyruvate metabolism_Homo sapiens_hsa006200.50713096
96Purine metabolism_Homo sapiens_hsa002300.50053164
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49927364
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49655473
99VEGF signaling pathway_Homo sapiens_hsa043700.48407776
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46573466
101Melanoma_Homo sapiens_hsa052180.46532799
102Choline metabolism in cancer_Homo sapiens_hsa052310.46192489
103Sulfur relay system_Homo sapiens_hsa041220.45321771
104Toxoplasmosis_Homo sapiens_hsa051450.44993793
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44593947
106Salmonella infection_Homo sapiens_hsa051320.44555864
107Renin-angiotensin system_Homo sapiens_hsa046140.44471006
108Wnt signaling pathway_Homo sapiens_hsa043100.43153205
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40748455
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40454288
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39841791
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.39806456
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38649076
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38116887
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.38086926
116B cell receptor signaling pathway_Homo sapiens_hsa046620.36068969
117Amoebiasis_Homo sapiens_hsa051460.35844631
118Glioma_Homo sapiens_hsa052140.35842966
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.34887482
120Measles_Homo sapiens_hsa051620.32016906
121FoxO signaling pathway_Homo sapiens_hsa040680.31537111
122N-Glycan biosynthesis_Homo sapiens_hsa005100.29406529
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28792883

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