YARS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.74087925
2nuclear pore organization (GO:0006999)5.06869176
3histone H2B ubiquitination (GO:0033523)4.66145726
4formation of translation preinitiation complex (GO:0001731)4.60754747
5mitotic sister chromatid segregation (GO:0000070)4.50864403
6mitotic chromosome condensation (GO:0007076)4.47598929
7cell fate commitment involved in formation of primary germ layer (GO:0060795)4.42503004
8pore complex assembly (GO:0046931)4.34168344
9telomere maintenance via semi-conservative replication (GO:0032201)4.29541439
10neuron cell-cell adhesion (GO:0007158)4.28136870
11sister chromatid segregation (GO:0000819)4.19768399
12DNA replication checkpoint (GO:0000076)4.02685264
13mitotic nuclear envelope disassembly (GO:0007077)4.00845343
14IMP biosynthetic process (GO:0006188)3.93322340
15protein localization to chromosome, centromeric region (GO:0071459)3.92071743
16positive regulation of dendritic spine morphogenesis (GO:0061003)3.91520617
17establishment of integrated proviral latency (GO:0075713)3.89499676
18Golgi transport vesicle coating (GO:0048200)3.87238893
19COPI coating of Golgi vesicle (GO:0048205)3.87238893
20protein localization to kinetochore (GO:0034501)3.86841293
21proline biosynthetic process (GO:0006561)3.86823317
22regulation of timing of cell differentiation (GO:0048505)3.79203447
23nuclear envelope disassembly (GO:0051081)3.76859766
24membrane disassembly (GO:0030397)3.76859766
25serine family amino acid biosynthetic process (GO:0009070)3.75368045
26negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.73127031
27regulation of translational termination (GO:0006449)3.70153559
28DNA topological change (GO:0006265)3.66331667
29regulation of development, heterochronic (GO:0040034)3.61280730
30mitotic metaphase plate congression (GO:0007080)3.60440144
31telomere maintenance via recombination (GO:0000722)3.60320790
32regulation of translational elongation (GO:0006448)3.59108467
33positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.58683759
34nucleobase biosynthetic process (GO:0046112)3.55148821
35tetrahydrofolate metabolic process (GO:0046653)3.53295223
36purine nucleobase biosynthetic process (GO:0009113)3.51370889
37protein complex localization (GO:0031503)3.50436406
38IMP metabolic process (GO:0046040)3.48983306
39central nervous system myelination (GO:0022010)3.42719243
40axon ensheathment in central nervous system (GO:0032291)3.42719243
41mitotic recombination (GO:0006312)3.40661178
42spliceosomal tri-snRNP complex assembly (GO:0000244)3.35863226
43mitotic sister chromatid cohesion (GO:0007064)3.35157619
44peptidyl-arginine omega-N-methylation (GO:0035247)3.33768304
45nucleobase-containing small molecule interconversion (GO:0015949)3.32982600
46DNA duplex unwinding (GO:0032508)3.32061302
47regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.30577733
48heterochromatin organization (GO:0070828)3.28772134
49regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.27884063
50histone arginine methylation (GO:0034969)3.24228081
51negative regulation of mRNA processing (GO:0050686)3.22871709
52DNA geometric change (GO:0032392)3.17953894
53cellular protein complex localization (GO:0034629)3.17497795
54regulation of RNA export from nucleus (GO:0046831)3.11539223
55telomere maintenance via telomere lengthening (GO:0010833)3.09254704
56viral mRNA export from host cell nucleus (GO:0046784)3.06935750
57regulation of mitotic spindle organization (GO:0060236)3.06288303
58nuclear envelope organization (GO:0006998)3.05925579
59negative regulation of mRNA metabolic process (GO:1903312)3.03883197
60DNA synthesis involved in DNA repair (GO:0000731)3.02313459
61non-recombinational repair (GO:0000726)3.00850016
62double-strand break repair via nonhomologous end joining (GO:0006303)3.00850016
63mitochondrial DNA metabolic process (GO:0032042)3.00358316
64DNA conformation change (GO:0071103)2.98576557
65short-term memory (GO:0007614)2.97030638
66folic acid-containing compound metabolic process (GO:0006760)2.96331904
67postsynaptic membrane organization (GO:0001941)2.96249385
68nucleotide-excision repair, DNA gap filling (GO:0006297)2.95615225
69metaphase plate congression (GO:0051310)2.94952210
70RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.94902161
71tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.94902161
72microtubule depolymerization (GO:0007019)2.94756340
73protein export from nucleus (GO:0006611)2.94454961
74establishment of viral latency (GO:0019043)2.94250089
75chromosome segregation (GO:0007059)2.94178864
76chromosome condensation (GO:0030261)2.92019995
77protein localization to synapse (GO:0035418)2.89935187
78pteridine-containing compound biosynthetic process (GO:0042559)2.89753114
79negative regulation of RNA splicing (GO:0033119)2.89679527
80positive regulation of synapse assembly (GO:0051965)2.89527114
81protein K6-linked ubiquitination (GO:0085020)2.86336930
82presynaptic membrane assembly (GO:0097105)2.85377371
83glutamine metabolic process (GO:0006541)2.84898780
84presynaptic membrane organization (GO:0097090)2.84080552
85post-embryonic morphogenesis (GO:0009886)2.83671251
86DNA replication initiation (GO:0006270)2.81936264
87regulation of mRNA 3-end processing (GO:0031440)2.81348436
88regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.80474639
89regulation of spindle organization (GO:0090224)2.78184632
90positive regulation of chromosome segregation (GO:0051984)2.77730494
91vocalization behavior (GO:0071625)2.77046509
92regulation of short-term neuronal synaptic plasticity (GO:0048172)2.76247076
93establishment of protein localization to mitochondrial membrane (GO:0090151)2.74903382
94peptidyl-arginine methylation (GO:0018216)2.73718184
95peptidyl-arginine N-methylation (GO:0035246)2.73718184
96mRNA transport (GO:0051028)2.73617503
97neuron recognition (GO:0008038)2.73071823
98positive regulation of dendritic spine development (GO:0060999)2.72289885
99CENP-A containing nucleosome assembly (GO:0034080)2.71772478
100DNA ligation (GO:0006266)2.70098011
101establishment of chromosome localization (GO:0051303)2.69905502
102negative regulation of chromosome segregation (GO:0051985)2.69877245
103folic acid metabolic process (GO:0046655)2.69534435
104regulation of chromosome segregation (GO:0051983)2.69489609
105nuclear envelope reassembly (GO:0031468)2.69245378
106mitotic nuclear envelope reassembly (GO:0007084)2.69245378
107protein-DNA complex disassembly (GO:0032986)2.68335727
108nucleosome disassembly (GO:0006337)2.68335727
109chromatin assembly or disassembly (GO:0006333)2.66100461
110rRNA transcription (GO:0009303)2.65656277
111DNA unwinding involved in DNA replication (GO:0006268)2.63231802
112transmission of nerve impulse (GO:0019226)2.62822896
113DNA replication-dependent nucleosome assembly (GO:0006335)2.62086932
114DNA replication-dependent nucleosome organization (GO:0034723)2.62086932
115DNA damage response, detection of DNA damage (GO:0042769)2.61506965
116cell migration in hindbrain (GO:0021535)2.61138012
117* tRNA aminoacylation for protein translation (GO:0006418)2.59559216
118deoxyribonucleotide biosynthetic process (GO:0009263)2.58707652
119righting reflex (GO:0060013)2.58363660
120rRNA modification (GO:0000154)2.58111193
121microtubule polymerization or depolymerization (GO:0031109)2.57211977
122long-chain fatty acid biosynthetic process (GO:0042759)2.55140824
123positive regulation of DNA-templated transcription, elongation (GO:0032786)2.54711455
124ribosome biogenesis (GO:0042254)2.53545949
125amino acid import (GO:0043090)2.53377457
126positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.51210884
127ribosomal large subunit biogenesis (GO:0042273)2.47864203
128* amino acid activation (GO:0043038)2.46545158
129* tRNA aminoacylation (GO:0043039)2.46545158
130negative regulation of microtubule polymerization (GO:0031115)2.45852779
131rRNA processing (GO:0006364)2.45652939
132mRNA polyadenylation (GO:0006378)2.45224264
133ribonucleoprotein complex biogenesis (GO:0022613)2.44656983
134transcription elongation from RNA polymerase I promoter (GO:0006362)2.44574535
135response to pheromone (GO:0019236)2.44364498
136spliceosomal snRNP assembly (GO:0000387)2.43581470
137ionotropic glutamate receptor signaling pathway (GO:0035235)2.43239597
138rRNA metabolic process (GO:0016072)2.40932911
139neuronal action potential propagation (GO:0019227)2.40227259
140keratinocyte development (GO:0003334)2.39819882
141negative regulation of DNA recombination (GO:0045910)2.39475100
142folic acid-containing compound biosynthetic process (GO:0009396)2.39342461
143gamma-aminobutyric acid signaling pathway (GO:0007214)2.37913668
144maturation of SSU-rRNA (GO:0030490)2.37566175
145limb bud formation (GO:0060174)2.37444420
146L-serine metabolic process (GO:0006563)2.36969518
147neuron-neuron synaptic transmission (GO:0007270)2.36878680
148ribosome assembly (GO:0042255)2.36467213
149ribosomal small subunit biogenesis (GO:0042274)2.35429083
150DNA strand elongation involved in DNA replication (GO:0006271)2.34946254
151cerebral cortex radially oriented cell migration (GO:0021799)2.34035037
152termination of RNA polymerase III transcription (GO:0006386)2.33975102
153transcription elongation from RNA polymerase III promoter (GO:0006385)2.33975102
154glutamate receptor signaling pathway (GO:0007215)2.33874455
155dendritic spine morphogenesis (GO:0060997)2.33117914
156synaptic transmission, glutamatergic (GO:0035249)2.33088772
157regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)2.31819256
158positive regulation of mRNA 3-end processing (GO:0031442)2.29691076
159startle response (GO:0001964)2.28815175
160axonal fasciculation (GO:0007413)2.28700295
161rRNA methylation (GO:0031167)2.26311320
162maturation of 5.8S rRNA (GO:0000460)2.25413691
163regulation of translational fidelity (GO:0006450)2.23402013
164negative regulation of B cell mediated immunity (GO:0002713)2.22573531
165negative regulation of immunoglobulin mediated immune response (GO:0002890)2.22573531
166spliceosomal complex assembly (GO:0000245)2.22254802
167termination of RNA polymerase I transcription (GO:0006363)2.21872128
168DNA strand elongation (GO:0022616)2.21229651
169layer formation in cerebral cortex (GO:0021819)2.20506916
170adult walking behavior (GO:0007628)2.19467541
171positive regulation of synapse maturation (GO:0090129)2.18696990
172negative regulation of synaptic transmission, GABAergic (GO:0032229)2.18180154
173regulation of synapse maturation (GO:0090128)2.17978127
174establishment of mitochondrion localization (GO:0051654)2.16945028
175eyelid development in camera-type eye (GO:0061029)2.14818410

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.37042480
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.93076498
3EZH2_22144423_ChIP-Seq_EOC_Human3.06156799
4GBX2_23144817_ChIP-Seq_PC3_Human2.85548673
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.77341380
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.74060341
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.62198198
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.44637756
9NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39505752
10* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.33706940
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.28179192
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.28179192
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.28179192
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.22375816
15DCP1A_22483619_ChIP-Seq_HELA_Human2.14460608
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.14310391
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.11854807
18MYC_22102868_ChIP-Seq_BL_Human2.09829649
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06456104
20POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.06397175
21AR_21909140_ChIP-Seq_LNCAP_Human2.04167639
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.03741210
23ZFX_18555785_ChIP-Seq_MESCs_Mouse2.00615283
24CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.96955293
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.96777218
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.96692164
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.95588337
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91546836
29* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.86160109
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.82706170
31POU5F1_16153702_ChIP-ChIP_HESCs_Human1.81658510
32GABP_19822575_ChIP-Seq_HepG2_Human1.81482196
33CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.81480515
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75400614
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74238541
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71053434
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.66507641
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66328841
39KDM5A_27292631_Chip-Seq_BREAST_Human1.65195706
40FOXP3_21729870_ChIP-Seq_TREG_Human1.63585104
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63223471
42TAF15_26573619_Chip-Seq_HEK293_Human1.63040304
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.60120774
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59619011
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.59147978
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.58003702
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.55637784
48* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.52894490
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52487025
50FOXM1_23109430_ChIP-Seq_U2OS_Human1.52340462
51REST_21632747_ChIP-Seq_MESCs_Mouse1.50272243
52* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49523492
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48800951
54* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.48740706
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.47264060
56SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.47157865
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.46403549
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45972266
59CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.45591459
60RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44681107
61EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44681107
62CIITA_25753668_ChIP-Seq_RAJI_Human1.44265698
63KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.44245260
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43606844
65* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.40227032
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40157274
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40122467
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40049898
69EST1_17652178_ChIP-ChIP_JURKAT_Human1.39912321
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.39871745
71SOX2_16153702_ChIP-ChIP_HESCs_Human1.39414733
72SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.38424541
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37963616
74ZNF263_19887448_ChIP-Seq_K562_Human1.37880892
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.37682578
76EZH2_27294783_Chip-Seq_ESCs_Mouse1.37525095
77VDR_23849224_ChIP-Seq_CD4+_Human1.37372788
78AR_21572438_ChIP-Seq_LNCaP_Human1.34809934
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33650373
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33636379
81SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.32104698
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.31342165
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31109386
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30827846
85MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.30360687
86SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29369663
87GABP_17652178_ChIP-ChIP_JURKAT_Human1.28135756
88THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27940366
89SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.27863739
90STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27578274
91* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.25805019
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24777685
93ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24411034
94* TTF2_22483619_ChIP-Seq_HELA_Human1.23007546
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22551188
96CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22530189
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22320297
98* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21859667
99RNF2_27304074_Chip-Seq_NSC_Mouse1.20686948
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20490516
101RNF2_27304074_Chip-Seq_ESCs_Mouse1.20422811
102PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19386741
103SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19240857
104TFEB_21752829_ChIP-Seq_HELA_Human1.18946985
105* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18589019
106POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17730742
107ELK1_19687146_ChIP-ChIP_HELA_Human1.17339867
108REST_18959480_ChIP-ChIP_MESCs_Mouse1.15970910
109SRF_21415370_ChIP-Seq_HL-1_Mouse1.15134725
110NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12634286
111YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12541512
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12495614
113IRF1_19129219_ChIP-ChIP_H3396_Human1.12094279
114SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11994209
115IGF1R_20145208_ChIP-Seq_DFB_Human1.11685131
116* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10766453
117CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10547606
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10169869
119* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08623232
120EWS_26573619_Chip-Seq_HEK293_Human1.06585836
121ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06090214
122PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05130379
123CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.04920547
124FUS_26573619_Chip-Seq_HEK293_Human1.03852361
125NCOR1_26117541_ChIP-Seq_K562_Human1.03752568
126XRN2_22483619_ChIP-Seq_HELA_Human1.03743047
127ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03262383
128MYC_18940864_ChIP-ChIP_HL60_Human1.02742841
129ERG_21242973_ChIP-ChIP_JURKAT_Human1.01611540
130PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01472439
131CHD1_26751641_Chip-Seq_LNCaP_Human1.00323466
132TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99230190
133SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98510425
134* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98336867
135SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.98041728
136* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97511316
137CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97317452
138FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.96523571
139DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95780116
140ATF3_27146783_Chip-Seq_COLON_Human0.95621815
141PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95428240
142SALL1_21062744_ChIP-ChIP_HESCs_Human0.95201666
143KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94696970
144VDR_21846776_ChIP-Seq_THP-1_Human0.94241778
145* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94079659
146NANOG_21062744_ChIP-ChIP_HESCs_Human0.92211962
147EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91549392
148PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91261932
149MTF2_20144788_ChIP-Seq_MESCs_Mouse0.91033656
150SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90811723
151RING1B_27294783_Chip-Seq_NPCs_Mouse0.90713449
152STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.90621215
153NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.90514460
154TCF3_18692474_ChIP-Seq_MESCs_Mouse0.89803860
155NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.89571886
156RING1B_27294783_Chip-Seq_ESCs_Mouse0.89551069
157SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89162383
158FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89146012
159NANOG_16153702_ChIP-ChIP_HESCs_Human0.89123146
160HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.89045233
161SMAD3_21741376_ChIP-Seq_EPCs_Human0.88839242
162ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87597229
163* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86924954
164TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.86726981
165TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86518079
166TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80652390
167ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80282503
168ELK3_25401928_ChIP-Seq_HUVEC_Human0.79924808

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.12852775
2MP0008007_abnormal_cellular_replicative2.87366468
3MP0001730_embryonic_growth_arrest2.58226175
4MP0004233_abnormal_muscle_weight2.52025910
5MP0000350_abnormal_cell_proliferation2.51520193
6MP0002102_abnormal_ear_morphology2.34135044
7MP0003136_yellow_coat_color2.27760727
8MP0004859_abnormal_synaptic_plasticity2.25364097
9MP0004270_analgesia2.22730810
10MP0002877_abnormal_melanocyte_morpholog2.20276208
11MP0005423_abnormal_somatic_nervous2.15032349
12MP0001968_abnormal_touch/_nociception2.13512296
13MP0005451_abnormal_body_composition2.12873072
14MP0008932_abnormal_embryonic_tissue2.09862168
15MP0004142_abnormal_muscle_tone2.07294442
16MP0003635_abnormal_synaptic_transmissio2.04620325
17MP0001188_hyperpigmentation2.04130294
18MP0005379_endocrine/exocrine_gland_phen1.97878042
19MP0001486_abnormal_startle_reflex1.96308771
20MP0003705_abnormal_hypodermis_morpholog1.96051132
21MP0002080_prenatal_lethality1.95989774
22MP0005380_embryogenesis_phenotype1.94021143
23MP0001672_abnormal_embryogenesis/_devel1.94021143
24MP0006072_abnormal_retinal_apoptosis1.93884065
25MP0001697_abnormal_embryo_size1.90744451
26MP0001529_abnormal_vocalization1.90612701
27MP0002734_abnormal_mechanical_nocicepti1.88738303
28MP0006292_abnormal_olfactory_placode1.88497412
29MP0000778_abnormal_nervous_system1.88259824
30MP0009046_muscle_twitch1.86705932
31MP0003111_abnormal_nucleus_morphology1.81716523
32MP0002736_abnormal_nociception_after1.81227533
33MP0009672_abnormal_birth_weight1.78709512
34MP0009745_abnormal_behavioral_response1.73511217
35MP0003693_abnormal_embryo_hatching1.71761519
36MP0003984_embryonic_growth_retardation1.71517375
37MP0003941_abnormal_skin_development1.70933262
38MP0000313_abnormal_cell_death1.70479607
39MP0008058_abnormal_DNA_repair1.68819260
40MP0010352_gastrointestinal_tract_polyps1.68198069
41MP0002396_abnormal_hematopoietic_system1.68189425
42MP0002735_abnormal_chemical_nociception1.68169313
43MP0002064_seizures1.67847536
44MP0002184_abnormal_innervation1.66422756
45MP0004957_abnormal_blastocyst_morpholog1.64640245
46MP0002272_abnormal_nervous_system1.63700249
47MP0002088_abnormal_embryonic_growth/wei1.62696852
48MP0009697_abnormal_copulation1.60259111
49MP0001440_abnormal_grooming_behavior1.59454774
50MP0010094_abnormal_chromosome_stability1.57761781
51MP0002085_abnormal_embryonic_tissue1.54573111
52MP0006035_abnormal_mitochondrial_morpho1.54204076
53MP0002084_abnormal_developmental_patter1.54135697
54MP0003938_abnormal_ear_development1.52915177
55MP0000462_abnormal_digestive_system1.51760218
56MP0002067_abnormal_sensory_capabilities1.51418074
57MP0004133_heterotaxia1.51330166
58MP0010307_abnormal_tumor_latency1.50393753
59MP0008057_abnormal_DNA_replication1.49870826
60MP0002572_abnormal_emotion/affect_behav1.49762261
61MP0002063_abnormal_learning/memory/cond1.46887783
62MP0000358_abnormal_cell_content/1.46545535
63MP0005623_abnormal_meninges_morphology1.45396788
64MP0000955_abnormal_spinal_cord1.44750912
65MP0006276_abnormal_autonomic_nervous1.44546371
66MP0005076_abnormal_cell_differentiation1.42498762
67MP0001727_abnormal_embryo_implantation1.39381365
68MP0001661_extended_life_span1.38837631
69MP0002086_abnormal_extraembryonic_tissu1.38453310
70MP0002751_abnormal_autonomic_nervous1.37833593
71MP0005501_abnormal_skin_physiology1.35572412
72MP0004742_abnormal_vestibular_system1.34015183
73MP0004197_abnormal_fetal_growth/weight/1.32256698
74MP0002733_abnormal_thermal_nociception1.30765844
75MP0003718_maternal_effect1.29079372
76MP0002557_abnormal_social/conspecific_i1.28831860
77MP0001970_abnormal_pain_threshold1.28350934
78MP0000631_abnormal_neuroendocrine_gland1.25965917
79MP0003861_abnormal_nervous_system1.25836916
80MP0002752_abnormal_somatic_nervous1.25656120
81MP0000049_abnormal_middle_ear1.25263803
82MP0009379_abnormal_foot_pigmentation1.25103370
83MP0002882_abnormal_neuron_morphology1.24105962
84MP0004147_increased_porphyrin_level1.22530070
85MP0001905_abnormal_dopamine_level1.21068017
86MP0004185_abnormal_adipocyte_glucose1.20761316
87MP0004808_abnormal_hematopoietic_stem1.19520968
88MP0008260_abnormal_autophagy1.18410990
89MP0005409_darkened_coat_color1.17448705
90MP0003806_abnormal_nucleotide_metabolis1.16535656
91MP0000678_abnormal_parathyroid_gland1.16331710
92MP0005384_cellular_phenotype1.16053203
93MP0001485_abnormal_pinna_reflex1.15587805
94MP0002019_abnormal_tumor_incidence1.13964299
95MP0005621_abnormal_cell_physiology1.12231605
96MP0000026_abnormal_inner_ear1.12148113
97MP0003566_abnormal_cell_adhesion1.11094884
98MP0003656_abnormal_erythrocyte_physiolo1.10453013
99MP0009250_abnormal_appendicular_skeleto1.10209901
100MP0002152_abnormal_brain_morphology1.09668001
101MP0008438_abnormal_cutaneous_collagen1.09184774
102MP0003186_abnormal_redox_activity1.07953840
103MP0003890_abnormal_embryonic-extraembry1.07907837
104MP0000613_abnormal_salivary_gland1.07840598
105MP0000490_abnormal_crypts_of1.07276723
106MP0000566_synostosis1.06322753
107MP0001963_abnormal_hearing_physiology1.06288509
108MP0003077_abnormal_cell_cycle1.05208252
109MP0003937_abnormal_limbs/digits/tail_de1.04599456
110MP0002066_abnormal_motor_capabilities/c1.02295782
111MP0003123_paternal_imprinting1.02125110
112MP0005499_abnormal_olfactory_system1.01001410
113MP0005394_taste/olfaction_phenotype1.01001410
114MP0003122_maternal_imprinting0.99868136
115MP0002163_abnormal_gland_morphology0.99064956
116MP0001348_abnormal_lacrimal_gland0.97462258
117MP0002249_abnormal_larynx_morphology0.95830425
118MP0003221_abnormal_cardiomyocyte_apopto0.94468369
119MP0004885_abnormal_endolymph0.93875623
120MP0005551_abnormal_eye_electrophysiolog0.92401725
121MP0003119_abnormal_digestive_system0.91589948
122MP0001986_abnormal_taste_sensitivity0.91050171
123MP0008789_abnormal_olfactory_epithelium0.90735386
124MP0009703_decreased_birth_body0.89564473
125MP0005253_abnormal_eye_physiology0.89490667
126MP0002210_abnormal_sex_determination0.88926065
127MP0004811_abnormal_neuron_physiology0.88857351
128MP0003755_abnormal_palate_morphology0.87841299
129MP0003385_abnormal_body_wall0.86966419
130MP0000703_abnormal_thymus_morphology0.82607010
131MP0002111_abnormal_tail_morphology0.82444686
132MP0003121_genomic_imprinting0.81515713
133MP0002234_abnormal_pharynx_morphology0.81407004
134MP0005645_abnormal_hypothalamus_physiol0.81298685
135MP0005171_absent_coat_pigmentation0.81284324
136MP0002796_impaired_skin_barrier0.81246586
137MP0000762_abnormal_tongue_morphology0.80362373
138MP0001299_abnormal_eye_distance/0.80271121
139MP0006036_abnormal_mitochondrial_physio0.80139439
140MP0005386_behavior/neurological_phenoty0.79825464
141MP0004924_abnormal_behavior0.79825464
142MP0003283_abnormal_digestive_organ0.79521219
143MP0000537_abnormal_urethra_morphology0.79208731
144MP0004145_abnormal_muscle_electrophysio0.78712543
145MP0002269_muscular_atrophy0.78107682
146MP0001881_abnormal_mammary_gland0.77677035
147MP0002653_abnormal_ependyma_morphology0.77315469
148MP0002697_abnormal_eye_size0.75829102
149MP0002229_neurodegeneration0.75397944
150MP0004272_abnormal_basement_membrane0.75334710
151MP0003786_premature_aging0.75237237
152MP0003634_abnormal_glial_cell0.74838962
153MP0005646_abnormal_pituitary_gland0.74618624
154MP0003567_abnormal_fetal_cardiomyocyte0.74501754
155MP0002060_abnormal_skin_morphology0.73437306
156MP0008770_decreased_survivor_rate0.73240197
157MP0001346_abnormal_lacrimal_gland0.71927387
158MP0001145_abnormal_male_reproductive0.71565202
159MP0008995_early_reproductive_senescence0.70312108
160MP0009333_abnormal_splenocyte_physiolog0.68764808
161MP0003942_abnormal_urinary_system0.67262496
162MP0003315_abnormal_perineum_morphology0.67186983
163MP0001929_abnormal_gametogenesis0.66775026
164MP0005083_abnormal_biliary_tract0.66594631
165MP0000428_abnormal_craniofacial_morphol0.62037449
166MP0003115_abnormal_respiratory_system0.62023624
167MP0008877_abnormal_DNA_methylation0.61966691
168MP0000747_muscle_weakness0.61720581
169MP0000003_abnormal_adipose_tissue0.61419375
170MP0010030_abnormal_orbit_morphology0.60851266
171MP0002970_abnormal_white_adipose0.59714987
172MP0001849_ear_inflammation0.59216036
173MP0009931_abnormal_skin_appearance0.59125135
174MP0003699_abnormal_female_reproductive0.58983031
175MP0001873_stomach_inflammation0.56851202
176MP0001915_intracranial_hemorrhage0.55889994
177MP0002161_abnormal_fertility/fecundity0.54868177
178MP0000653_abnormal_sex_gland0.54089934

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.31972633
2Cortical dysplasia (HP:0002539)4.30152043
3Abnormal gallbladder physiology (HP:0012438)4.22381598
4Cholecystitis (HP:0001082)4.22381598
5Abnormality of the parathyroid morphology (HP:0011766)3.77727115
6Chromsome breakage (HP:0040012)3.65828520
7Abnormality of the labia minora (HP:0012880)3.27592833
8Septo-optic dysplasia (HP:0100842)3.25548824
9Duplicated collecting system (HP:0000081)3.18065808
10Insomnia (HP:0100785)3.15322118
11Cerebral hypomyelination (HP:0006808)3.12672201
12Increased nuchal translucency (HP:0010880)3.03818555
13Progressive muscle weakness (HP:0003323)3.02611510
14Birth length less than 3rd percentile (HP:0003561)2.95953972
15Multiple enchondromatosis (HP:0005701)2.90144975
16Progressive external ophthalmoplegia (HP:0000590)2.83973015
17Focal motor seizures (HP:0011153)2.71626288
18Nephroblastoma (Wilms tumor) (HP:0002667)2.66839587
19Absent radius (HP:0003974)2.65597400
20Absent forearm bone (HP:0003953)2.60419781
21Aplasia involving forearm bones (HP:0009822)2.60419781
22Congenital stationary night blindness (HP:0007642)2.59397716
23Hyperacusis (HP:0010780)2.58311996
24Abnormality of the renal collecting system (HP:0004742)2.57827809
25Abnormality of reticulocytes (HP:0004312)2.57782310
26Embryonal renal neoplasm (HP:0011794)2.53110754
27Aplasia/Hypoplasia of the spleen (HP:0010451)2.50731021
28Reticulocytosis (HP:0001923)2.49415124
29* Upper limb muscle weakness (HP:0003484)2.46225607
30Atelectasis (HP:0100750)2.39416014
31Proximal placement of thumb (HP:0009623)2.36310970
32Asplenia (HP:0001746)2.34101269
33Truncus arteriosus (HP:0001660)2.32646715
34Selective tooth agenesis (HP:0001592)2.32507343
35Hand muscle atrophy (HP:0009130)2.29279622
36Hypoplasia of the pons (HP:0012110)2.29016291
37Deviation of the thumb (HP:0009603)2.28348130
38Absent septum pellucidum (HP:0001331)2.26313234
39Reticulocytopenia (HP:0001896)2.26143515
40Overlapping toe (HP:0001845)2.25711870
41Abnormality of the umbilical cord (HP:0010881)2.24912083
42Optic nerve hypoplasia (HP:0000609)2.24882177
43Focal seizures (HP:0007359)2.24819834
44Myelodysplasia (HP:0002863)2.24456563
45Long palpebral fissure (HP:0000637)2.21590971
46Short middle phalanx of the 5th finger (HP:0004220)2.19130241
47Abnormality of the septum pellucidum (HP:0007375)2.18372989
48Breast hypoplasia (HP:0003187)2.17683520
49Abnormality of cells of the erythroid lineage (HP:0012130)2.15167165
50Cholelithiasis (HP:0001081)2.15133752
51Febrile seizures (HP:0002373)2.13078293
52Long foot (HP:0001833)2.12468463
53Large hands (HP:0001176)2.11928016
54Abnormality of homocysteine metabolism (HP:0010919)2.11389858
55Homocystinuria (HP:0002156)2.11389858
56Concave nail (HP:0001598)2.11183649
57Entropion (HP:0000621)2.10701314
58Aplasia/Hypoplasia of the sacrum (HP:0008517)2.09838942
59Epileptic encephalopathy (HP:0200134)2.09547912
60Hypoplastic pelvis (HP:0008839)2.09518073
61Ankyloglossia (HP:0010296)2.09474347
62CNS hypomyelination (HP:0003429)2.09429888
63Distal upper limb amyotrophy (HP:0007149)2.07551974
64Upper limb amyotrophy (HP:0009129)2.07551974
65Abnormality of the pons (HP:0007361)2.07025917
66Overriding aorta (HP:0002623)2.03936169
67Poikiloderma (HP:0001029)2.03236917
68Partial agenesis of the corpus callosum (HP:0001338)2.03058861
69Horseshoe kidney (HP:0000085)2.01406333
70Abnormality of chromosome stability (HP:0003220)2.00875971
71Abnormality of cochlea (HP:0000375)1.99814899
72Ragged-red muscle fibers (HP:0003200)1.98499652
73Trismus (HP:0000211)1.96445219
74Aplasia/Hypoplasia of the earlobes (HP:0009906)1.95974701
75Meckel diverticulum (HP:0002245)1.95491191
76Duodenal stenosis (HP:0100867)1.95252428
77Small intestinal stenosis (HP:0012848)1.95252428
78Chin dimple (HP:0010751)1.95014451
79Renal duplication (HP:0000075)1.94580622
80Spinal cord compression (HP:0002176)1.93985601
81Dynein arm defect of respiratory motile cilia (HP:0012255)1.93726991
82Absent/shortened dynein arms (HP:0200106)1.93726991
83Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93106979
84Dysmetric saccades (HP:0000641)1.91872685
85Spastic diplegia (HP:0001264)1.91872102
86Duplication of thumb phalanx (HP:0009942)1.91785635
87Carpal bone hypoplasia (HP:0001498)1.90890027
88Abnormal number of erythroid precursors (HP:0012131)1.90532056
89Gastroesophageal reflux (HP:0002020)1.90500273
90Deep palmar crease (HP:0006191)1.90267827
91Aplastic anemia (HP:0001915)1.88070949
92Hyperthyroidism (HP:0000836)1.87759722
93Abnormal gallbladder morphology (HP:0012437)1.87606410
94Premature rupture of membranes (HP:0001788)1.87450778
95Renal agenesis (HP:0000104)1.87270788
96Abnormality of abdominal situs (HP:0011620)1.87088253
97Abdominal situs inversus (HP:0003363)1.87088253
98Abnormality of the preputium (HP:0100587)1.86961310
99Aplasia/Hypoplasia of the uvula (HP:0010293)1.86782426
100Microvesicular hepatic steatosis (HP:0001414)1.86560017
101Cafe-au-lait spot (HP:0000957)1.86229106
102Abnormality of glycolysis (HP:0004366)1.86193242
103Increased serum pyruvate (HP:0003542)1.86193242
104Abnormality of the ileum (HP:0001549)1.85566749
105Abnormal number of incisors (HP:0011064)1.84710477
106Premature ovarian failure (HP:0008209)1.84585480
107Atonic seizures (HP:0010819)1.84535376
108Shoulder girdle muscle weakness (HP:0003547)1.84003125
109Supernumerary spleens (HP:0009799)1.83992674
110Esotropia (HP:0000565)1.83649465
111Morphological abnormality of the inner ear (HP:0011390)1.83042005
112Postnatal microcephaly (HP:0005484)1.83041573
113Cutaneous melanoma (HP:0012056)1.82006084
114Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81872401
115Abnormality of alanine metabolism (HP:0010916)1.81872401
116Hyperalaninemia (HP:0003348)1.81872401
117Delusions (HP:0000746)1.81833454
118Hammertoe (HP:0001765)1.81622211
119Abnormality of oral frenula (HP:0000190)1.81008423
120Abnormal umbilical cord blood vessels (HP:0011403)1.80953731
121Single umbilical artery (HP:0001195)1.80953731
122Abnormality of the fetal cardiovascular system (HP:0010948)1.80953731
123Abnormality of the calcaneus (HP:0008364)1.80552890
124Nonimmune hydrops fetalis (HP:0001790)1.80333404
125Ankle clonus (HP:0011448)1.80159815
126Abnormality of the gallbladder (HP:0005264)1.78654860
127Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78616581
128Secondary amenorrhea (HP:0000869)1.78518286
129Rough bone trabeculation (HP:0100670)1.78352902
130Septate vagina (HP:0001153)1.78096570
131Elfin facies (HP:0004428)1.77261988
132High anterior hairline (HP:0009890)1.77061623
133Adrenal hypoplasia (HP:0000835)1.76767117
134Abnormality of the carotid arteries (HP:0005344)1.76310046
135Decreased lacrimation (HP:0000633)1.75459521
136Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.75162648
137Degeneration of the lateral corticospinal tracts (HP:0002314)1.75162648
138Premature skin wrinkling (HP:0100678)1.74533143
139Abnormality of the antihelix (HP:0009738)1.73672384
140Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.72702464
141Pointed chin (HP:0000307)1.71609811
142Calcaneovalgus deformity (HP:0001848)1.71076667
143Orthostatic hypotension (HP:0001278)1.70824096
144Akinesia (HP:0002304)1.69724534
145Anophthalmia (HP:0000528)1.68978245
146Alacrima (HP:0000522)1.68399670
147Patellar dislocation (HP:0002999)1.68012195
148Unilateral renal agenesis (HP:0000122)1.67582351
149Disproportionate tall stature (HP:0001519)1.67261493
150Abnormality of the corticospinal tract (HP:0002492)1.66545843
151Missing ribs (HP:0000921)1.66506179
152Overfolded helix (HP:0000396)1.65363633
153Squamous cell carcinoma (HP:0002860)1.64245317
154Abnormality of DNA repair (HP:0003254)1.64030620
155Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.62945837
156Hemiparesis (HP:0001269)1.62384888
157Hyperparathyroidism (HP:0000843)1.62171380
158Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.62077054
159Sensory axonal neuropathy (HP:0003390)1.61849990
160Limb dystonia (HP:0002451)1.61578058
161Short thumb (HP:0009778)1.60798099
162Spastic gait (HP:0002064)1.60787721
163External ophthalmoplegia (HP:0000544)1.60723588
164Hypoparathyroidism (HP:0000829)1.60482683
165Triphalangeal thumb (HP:0001199)1.59218612
166Myokymia (HP:0002411)1.58732660
167Cortical visual impairment (HP:0100704)1.58413260
168Broad-based gait (HP:0002136)1.57685512
169Seborrheic dermatitis (HP:0001051)1.57571424
170Ependymoma (HP:0002888)1.55783350
171Esophageal atresia (HP:0002032)1.54359323
172Abnormal respiratory epithelium morphology (HP:0012253)1.53864763
173Abnormal respiratory motile cilium morphology (HP:0005938)1.53864763
174Osteomalacia (HP:0002749)1.52671425
175Fetal akinesia sequence (HP:0001989)1.51042963

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.52345771
2CASK3.93514142
3EEF2K3.32045599
4PNCK3.14520147
5NEK12.94179769
6MARK12.93909782
7BUB12.85714582
8SMG12.85137675
9GRK12.79037316
10TLK12.58723994
11NTRK32.56884013
12TSSK62.51094285
13SCYL22.34848338
14VRK22.33089129
15CDK122.12917019
16WEE11.94923785
17TNIK1.82797742
18TIE11.69198566
19EPHA21.68859661
20MAP3K91.68619996
21IRAK31.68424442
22SRPK11.64379949
23NME11.58712099
24MKNK21.57295931
25BRSK11.56843332
26MAP3K81.56187252
27CDC71.50878769
28DYRK21.49188968
29AKT31.48997650
30MKNK11.42900742
31UHMK11.40874131
32MAPK131.39350345
33CLK11.29813033
34LATS21.28277243
35AURKA1.28021307
36ALK1.27301518
37TESK21.25864332
38NEK21.25756835
39MAP3K101.24778568
40PKN11.22259917
41BRSK21.20656316
42TRIB31.19928927
43PLK31.19824201
44VRK11.18763163
45NEK61.16412804
46TTK1.15831068
47PRKCI1.12890955
48EIF2AK21.12296554
49MAP3K41.11693261
50RPS6KB21.11072906
51PRPF4B1.08215238
52PIM21.07611742
53CDK41.06933890
54BCR1.06796981
55PRKCG1.06518601
56RAF11.05981923
57PLK11.05899586
58CDK81.05789382
59ARAF1.05645706
60LIMK11.05261602
61AURKB1.04932306
62MINK11.03774846
63PAK41.03587373
64BLK1.02241120
65NTRK10.99653779
66MAP2K70.99538106
67TRIM280.96250401
68PLK20.96110167
69IRAK20.96029376
70KSR20.95923624
71CHEK20.95776789
72TAF10.95739923
73STK390.93205552
74OXSR10.87659068
75EPHA40.87429877
76FES0.84400804
77NME20.83801294
78CDK190.81918995
79CSNK1E0.81529739
80ERBB40.81146857
81PDK20.79676423
82CHEK10.79235259
83CDK140.78402053
84NTRK20.78249204
85MTOR0.77818483
86CDK70.77622907
87CDK150.73318545
88STK100.71425360
89ROCK20.71273738
90PAK60.71109884
91CDK180.70618054
92CDK11A0.68376436
93DAPK10.66738720
94SIK30.66225225
95ADRBK20.65638001
96DYRK1A0.65469944
97CAMK2B0.63827248
98STK40.63805909
99RPS6KA40.63765023
100FGR0.62840329
101PASK0.61262882
102CCNB10.60310427
103PRKCE0.60163124
104YES10.59631323
105PBK0.59479759
106PAK10.59157428
107SIK20.58638187
108ATR0.58541760
109CDK10.58182341
110CSNK2A20.57888711
111AKT20.56723830
112TAOK20.56581424
113GRK50.56076884
114ICK0.56055744
115CDK50.55693956
116KSR10.55225007
117MAPKAPK50.54865316
118CSNK1G30.54397279
119BMX0.49923198
120PAK20.49322126
121CSNK1D0.49295719
122MST40.48768560
123CDK20.46749889
124EIF2AK30.46584948
125MAPK100.45821180
126CAMK2A0.45439142
127FER0.44668901
128MAP3K130.44392328
129ZAK0.43846800
130BRAF0.43731480
131MST1R0.42636716
132PLK40.42485864
133ATM0.41850393
134LATS10.40120630
135CSNK2A10.39757026
136CSNK1A1L0.39581491
137PRKDC0.39384701
138STK30.39266387
139CAMK2D0.38753412
140PIM10.37320933
141GSK3B0.36987371
142PRKCB0.36823265
143BRD40.36746991
144MAPK110.36560143
145EIF2AK10.36443835
146CDK90.35457301
147ILK0.34616387
148PKN20.33911108
149RPS6KA50.33486161

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.81083399
2Biosynthesis of amino acids_Homo sapiens_hsa012302.61766760
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.57327367
4* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.56761807
5Mismatch repair_Homo sapiens_hsa034302.42788270
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.37773825
7Fanconi anemia pathway_Homo sapiens_hsa034602.37605707
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.24982826
9DNA replication_Homo sapiens_hsa030302.24036606
10RNA polymerase_Homo sapiens_hsa030202.23748030
11One carbon pool by folate_Homo sapiens_hsa006702.21463155
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.20545464
13Phototransduction_Homo sapiens_hsa047442.15900366
14Ribosome_Homo sapiens_hsa030102.05234917
15Homologous recombination_Homo sapiens_hsa034402.01702093
16Spliceosome_Homo sapiens_hsa030401.95785133
17Proteasome_Homo sapiens_hsa030501.93762907
18Synaptic vesicle cycle_Homo sapiens_hsa047211.91599315
19Nucleotide excision repair_Homo sapiens_hsa034201.89010470
20Carbon metabolism_Homo sapiens_hsa012001.76000349
21RNA transport_Homo sapiens_hsa030131.75351190
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.74844539
23Non-homologous end-joining_Homo sapiens_hsa034501.74664640
24Selenocompound metabolism_Homo sapiens_hsa004501.66240602
25Vitamin B6 metabolism_Homo sapiens_hsa007501.57210417
26Oxidative phosphorylation_Homo sapiens_hsa001901.55628306
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50253118
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.47771774
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.44085854
30Collecting duct acid secretion_Homo sapiens_hsa049661.41883287
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40357726
32Pentose phosphate pathway_Homo sapiens_hsa000301.38944607
33mRNA surveillance pathway_Homo sapiens_hsa030151.36929064
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33092580
35Taste transduction_Homo sapiens_hsa047421.33004888
36Morphine addiction_Homo sapiens_hsa050321.32460957
37Glutamatergic synapse_Homo sapiens_hsa047241.32091727
38Pyruvate metabolism_Homo sapiens_hsa006201.31745240
39GABAergic synapse_Homo sapiens_hsa047271.30667364
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.27384872
41Serotonergic synapse_Homo sapiens_hsa047261.25860299
42Amphetamine addiction_Homo sapiens_hsa050311.23874251
43Pyrimidine metabolism_Homo sapiens_hsa002401.23784775
44Axon guidance_Homo sapiens_hsa043601.16549931
45Cell cycle_Homo sapiens_hsa041101.15509595
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.14012768
47Parkinsons disease_Homo sapiens_hsa050121.13020224
48Dopaminergic synapse_Homo sapiens_hsa047281.12684808
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11149500
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09584506
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08335413
52Oocyte meiosis_Homo sapiens_hsa041141.07334250
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05842752
54Basal transcription factors_Homo sapiens_hsa030221.04835877
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04104422
56Long-term depression_Homo sapiens_hsa047301.03839583
57Thyroid cancer_Homo sapiens_hsa052161.02307209
58Melanoma_Homo sapiens_hsa052181.02202665
59Alcoholism_Homo sapiens_hsa050341.01297698
60N-Glycan biosynthesis_Homo sapiens_hsa005101.01023059
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99942036
62Hedgehog signaling pathway_Homo sapiens_hsa043400.99812737
63Cocaine addiction_Homo sapiens_hsa050300.97648507
64Sulfur relay system_Homo sapiens_hsa041220.96171746
65Huntingtons disease_Homo sapiens_hsa050160.95294557
66Sphingolipid metabolism_Homo sapiens_hsa006000.93936200
67Purine metabolism_Homo sapiens_hsa002300.90220920
68Gap junction_Homo sapiens_hsa045400.89462629
69Base excision repair_Homo sapiens_hsa034100.89295654
70Vibrio cholerae infection_Homo sapiens_hsa051100.88491023
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.87794702
72Fructose and mannose metabolism_Homo sapiens_hsa000510.84567437
73Chronic myeloid leukemia_Homo sapiens_hsa052200.84350978
74Alzheimers disease_Homo sapiens_hsa050100.83502856
75Bladder cancer_Homo sapiens_hsa052190.83457758
76RNA degradation_Homo sapiens_hsa030180.80408351
77Basal cell carcinoma_Homo sapiens_hsa052170.79179996
78Olfactory transduction_Homo sapiens_hsa047400.78954495
79Cholinergic synapse_Homo sapiens_hsa047250.78579326
80Cardiac muscle contraction_Homo sapiens_hsa042600.77947020
81Long-term potentiation_Homo sapiens_hsa047200.77755620
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77330434
83Wnt signaling pathway_Homo sapiens_hsa043100.77214998
84Circadian entrainment_Homo sapiens_hsa047130.76979123
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75582540
86Calcium signaling pathway_Homo sapiens_hsa040200.73214324
87Viral carcinogenesis_Homo sapiens_hsa052030.73112881
88Lysine degradation_Homo sapiens_hsa003100.71846281
89Insulin secretion_Homo sapiens_hsa049110.70595435
90Ether lipid metabolism_Homo sapiens_hsa005650.66896052
91Oxytocin signaling pathway_Homo sapiens_hsa049210.66526254
92p53 signaling pathway_Homo sapiens_hsa041150.65662025
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65401116
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64022127
95Gastric acid secretion_Homo sapiens_hsa049710.62973924
96Salivary secretion_Homo sapiens_hsa049700.62174814
97ErbB signaling pathway_Homo sapiens_hsa040120.60377334
98Fatty acid elongation_Homo sapiens_hsa000620.59579049
99Hippo signaling pathway_Homo sapiens_hsa043900.57830180
100Steroid biosynthesis_Homo sapiens_hsa001000.56829039
101Melanogenesis_Homo sapiens_hsa049160.56603403
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55933958
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54248115
104Tight junction_Homo sapiens_hsa045300.53726765
105Pancreatic secretion_Homo sapiens_hsa049720.53138438
106Arginine biosynthesis_Homo sapiens_hsa002200.52944638
107Pancreatic cancer_Homo sapiens_hsa052120.52373850
108Ras signaling pathway_Homo sapiens_hsa040140.49480268
109Arginine and proline metabolism_Homo sapiens_hsa003300.48923548
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48811055
111Estrogen signaling pathway_Homo sapiens_hsa049150.48653804
112Galactose metabolism_Homo sapiens_hsa000520.48302399
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47862902
114Shigellosis_Homo sapiens_hsa051310.47742284
115Systemic lupus erythematosus_Homo sapiens_hsa053220.47407541
116Glioma_Homo sapiens_hsa052140.46495122
117Acute myeloid leukemia_Homo sapiens_hsa052210.44568131
118Folate biosynthesis_Homo sapiens_hsa007900.44293202
119Protein export_Homo sapiens_hsa030600.43512273
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42884365
121Apoptosis_Homo sapiens_hsa042100.42540261
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42379529
123Epstein-Barr virus infection_Homo sapiens_hsa051690.42180836
124Protein digestion and absorption_Homo sapiens_hsa049740.42180530
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42157020
126Colorectal cancer_Homo sapiens_hsa052100.42126867
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41789508
128Non-small cell lung cancer_Homo sapiens_hsa052230.40733212
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40690768
130MicroRNAs in cancer_Homo sapiens_hsa052060.40679664
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40668830
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40442192
133HTLV-I infection_Homo sapiens_hsa051660.39966535
134Regulation of autophagy_Homo sapiens_hsa041400.39329280
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39274473
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.39189700
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39104185
138Prion diseases_Homo sapiens_hsa050200.38352857
139Phospholipase D signaling pathway_Homo sapiens_hsa040720.38208772
140Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37656444
141GnRH signaling pathway_Homo sapiens_hsa049120.35770310
142Adherens junction_Homo sapiens_hsa045200.32376324
143Prostate cancer_Homo sapiens_hsa052150.32306519
144Glutathione metabolism_Homo sapiens_hsa004800.31453876
145Metabolic pathways_Homo sapiens_hsa011000.30307233
146Small cell lung cancer_Homo sapiens_hsa052220.30273142
147Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28198449
148Hepatitis B_Homo sapiens_hsa051610.26304732
149HIF-1 signaling pathway_Homo sapiens_hsa040660.25720179
150Fatty acid metabolism_Homo sapiens_hsa012120.25689006
151Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24990150
152mTOR signaling pathway_Homo sapiens_hsa041500.23201821
153Insulin signaling pathway_Homo sapiens_hsa049100.22527700
154Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22307538
155Propanoate metabolism_Homo sapiens_hsa006400.19971479
156Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18626710
157AMPK signaling pathway_Homo sapiens_hsa041520.18480824
158Endometrial cancer_Homo sapiens_hsa052130.16000012

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