XRRA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.93738752
2epithelial cilium movement (GO:0003351)9.86840489
3spermatid development (GO:0007286)9.69569149
4motile cilium assembly (GO:0044458)9.56662597
5reproduction (GO:0000003)8.94436183
6piRNA metabolic process (GO:0034587)8.64988617
7regulation of cilium movement (GO:0003352)8.46377299
8cilium movement (GO:0003341)8.22309981
9male meiosis (GO:0007140)7.89637437
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.81191848
11synaptonemal complex organization (GO:0070193)7.76754552
12synaptonemal complex assembly (GO:0007130)7.49778206
13single fertilization (GO:0007338)7.21521971
14negative regulation of inclusion body assembly (GO:0090084)7.11489792
15sperm capacitation (GO:0048240)6.92703803
16spermatogenesis (GO:0007283)6.60240769
17male gamete generation (GO:0048232)6.57829297
18organic cation transport (GO:0015695)6.31986018
19fertilization (GO:0009566)6.28191270
20gamete generation (GO:0007276)6.04538109
21microtubule depolymerization (GO:0007019)5.95860329
22regulation of inclusion body assembly (GO:0090083)5.81844579
23DNA methylation involved in gamete generation (GO:0043046)5.63405701
24male meiosis I (GO:0007141)5.57272145
25germ cell development (GO:0007281)5.50617902
26cellular process involved in reproduction in multicellular organism (GO:0022412)5.44006283
27calcium ion-dependent exocytosis (GO:0017156)5.30393794
28ventricular system development (GO:0021591)5.26041310
29chromosome organization involved in meiosis (GO:0070192)5.18602992
30regulation of microtubule-based movement (GO:0060632)5.00984205
31seminiferous tubule development (GO:0072520)4.91794133
32cell recognition (GO:0008037)4.88410239
33chromosome condensation (GO:0030261)4.85091693
34microtubule severing (GO:0051013)4.75701173
35spermatid nucleus differentiation (GO:0007289)4.75697327
36multicellular organismal reproductive process (GO:0048609)4.75068203
37meiotic nuclear division (GO:0007126)4.73584095
38DNA packaging (GO:0006323)4.67695200
39meiosis I (GO:0007127)4.47455699
40left/right pattern formation (GO:0060972)4.43462894
41glycerol ether metabolic process (GO:0006662)4.36264226
42response to pheromone (GO:0019236)4.25945324
43platelet dense granule organization (GO:0060155)4.20233859
44water-soluble vitamin biosynthetic process (GO:0042364)4.13584829
45respiratory chain complex IV assembly (GO:0008535)4.09848422
46ether metabolic process (GO:0018904)4.02786790
47genitalia morphogenesis (GO:0035112)3.98817427
48meiotic cell cycle (GO:0051321)3.96804374
49chaperone-mediated protein complex assembly (GO:0051131)3.95676323
50regulation of glucokinase activity (GO:0033131)3.84520529
51regulation of hexokinase activity (GO:1903299)3.84520529
52DNA double-strand break processing (GO:0000729)3.82610649
53multicellular organismal development (GO:0007275)3.82235414
54protein localization to cilium (GO:0061512)3.80204813
55cytochrome complex assembly (GO:0017004)3.78392648
56proteasome assembly (GO:0043248)3.76790256
57protein complex biogenesis (GO:0070271)3.74988748
58protein polyglutamylation (GO:0018095)3.71296132
59protein prenylation (GO:0018342)3.63616335
60prenylation (GO:0097354)3.63616335
61sexual reproduction (GO:0019953)3.61769840
62replication fork processing (GO:0031297)3.59805751
63single strand break repair (GO:0000012)3.57428903
64ketone body metabolic process (GO:1902224)3.57308703
65mannosylation (GO:0097502)3.49683472
66monoubiquitinated protein deubiquitination (GO:0035520)3.43744951
67inositol phosphate catabolic process (GO:0071545)3.40267421
68detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.39669520
69mitochondrial respiratory chain complex assembly (GO:0033108)3.36583329
70DNA deamination (GO:0045006)3.32879039
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.30179978
72mitochondrial respiratory chain complex I assembly (GO:0032981)3.30179978
73NADH dehydrogenase complex assembly (GO:0010257)3.30179978
74protein refolding (GO:0042026)3.30080622
75resolution of meiotic recombination intermediates (GO:0000712)3.27188381
76sequestering of actin monomers (GO:0042989)3.26890363
77regulation of spindle checkpoint (GO:0090231)3.26341128
78protein K11-linked deubiquitination (GO:0035871)3.23525632
79amino-acid betaine transport (GO:0015838)3.19976001
80carnitine transport (GO:0015879)3.19976001
81keratinocyte development (GO:0003334)3.19075329
82gene silencing by RNA (GO:0031047)3.16079491
83fucose catabolic process (GO:0019317)3.15911062
84L-fucose metabolic process (GO:0042354)3.15911062
85L-fucose catabolic process (GO:0042355)3.15911062
86cellular ketone body metabolic process (GO:0046950)3.14462290
87mitotic sister chromatid cohesion (GO:0007064)3.11961656
88axoneme assembly (GO:0035082)3.11563246
89intraciliary transport (GO:0042073)3.11424814
90meiotic cell cycle process (GO:1903046)3.10908555
91negative regulation of DNA-dependent DNA replication (GO:2000104)3.09377833
92synapsis (GO:0007129)3.09352095
93nucleus organization (GO:0006997)3.08709656
94phosphorylated carbohydrate dephosphorylation (GO:0046838)3.07938027
95inositol phosphate dephosphorylation (GO:0046855)3.07938027
96carnitine transmembrane transport (GO:1902603)3.07807763
97microtubule polymerization or depolymerization (GO:0031109)3.03194828
98positive regulation of glycolytic process (GO:0045821)2.97140990
99glycolytic process (GO:0006096)2.96960907
100neural tube formation (GO:0001841)2.96589793
101microtubule-based movement (GO:0007018)2.96421826
102signal peptide processing (GO:0006465)2.95729877
103negative regulation of organelle assembly (GO:1902116)2.93925182
104cilium organization (GO:0044782)2.93750028
105recombinational repair (GO:0000725)2.93045865
106double-strand break repair via homologous recombination (GO:0000724)2.90010119
107alditol metabolic process (GO:0019400)2.89643064
108polyol catabolic process (GO:0046174)2.89601465
109nucleoside diphosphate phosphorylation (GO:0006165)2.86073538
110behavioral response to nicotine (GO:0035095)2.85536594
111positive regulation of respiratory burst (GO:0060267)2.84918954
112peptidyl-histidine modification (GO:0018202)2.84657085
113nonmotile primary cilium assembly (GO:0035058)2.84580260
114secondary metabolite biosynthetic process (GO:0044550)2.84048886
115dopamine transport (GO:0015872)2.83841618
116nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.83798197
117interferon-gamma secretion (GO:0072643)2.82539781
118RNA localization (GO:0006403)2.80528861
119cilium assembly (GO:0042384)2.79719783
120exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.79068785
121anterograde synaptic vesicle transport (GO:0048490)2.76662248
122cellular component assembly involved in morphogenesis (GO:0010927)2.73502771
123RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.73324221
124lactate metabolic process (GO:0006089)2.73294921
125protein K6-linked ubiquitination (GO:0085020)2.73282092
126cilium morphogenesis (GO:0060271)2.72404158
127reciprocal meiotic recombination (GO:0007131)2.70854653
128reciprocal DNA recombination (GO:0035825)2.70854653
129regulation of DNA endoreduplication (GO:0032875)2.70577225
130photoreceptor cell maintenance (GO:0045494)2.69939963
131regulation of cilium assembly (GO:1902017)2.65569674
132gene silencing (GO:0016458)2.65146801
133establishment of protein localization to Golgi (GO:0072600)2.64814537
134RNA destabilization (GO:0050779)2.64263363
135peptidyl-glutamic acid modification (GO:0018200)2.64259186
136centriole replication (GO:0007099)2.63371045
137regulation of meiosis I (GO:0060631)2.62659866
138mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.62222985
139S-adenosylmethionine metabolic process (GO:0046500)2.61536088
140positive regulation of macrophage activation (GO:0043032)2.61000315
141indolalkylamine metabolic process (GO:0006586)2.58417072
142auditory receptor cell stereocilium organization (GO:0060088)2.56802629
143cornea development in camera-type eye (GO:0061303)2.56794224
144protein-cofactor linkage (GO:0018065)2.56708787
145preassembly of GPI anchor in ER membrane (GO:0016254)2.56089580
146rRNA methylation (GO:0031167)2.56038485
147positive regulation of protein autophosphorylation (GO:0031954)2.55850893
148regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.55354742
149somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.55072781
150isotype switching (GO:0045190)2.55072781
151somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.55072781
152tryptophan catabolic process (GO:0006569)2.53178990
153indole-containing compound catabolic process (GO:0042436)2.53178990
154indolalkylamine catabolic process (GO:0046218)2.53178990
155regulation of centriole replication (GO:0046599)2.51169305
156nuclear pore complex assembly (GO:0051292)2.50762909
157regulation of nuclear cell cycle DNA replication (GO:0033262)2.50691494
158kynurenine metabolic process (GO:0070189)2.50378808
159tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.50208639
160RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.50208639
161regulation of neurotransmitter uptake (GO:0051580)2.50150890
162negative regulation of JUN kinase activity (GO:0043508)2.49908875
163GTP biosynthetic process (GO:0006183)2.49164126
164protein targeting to Golgi (GO:0000042)2.48978428
165protein deneddylation (GO:0000338)2.48785625
166DNA catabolic process, exonucleolytic (GO:0000738)2.47187317
167rRNA modification (GO:0000154)2.45135254
168positive regulation of meiosis (GO:0045836)2.44998508
169sperm motility (GO:0030317)13.4504950
170fusion of sperm to egg plasma membrane (GO:0007342)13.0495538
171acrosome reaction (GO:0007340)11.7145170
172cell wall macromolecule catabolic process (GO:0016998)11.7008902
173cell wall macromolecule metabolic process (GO:0044036)11.7008902
174sperm-egg recognition (GO:0035036)11.3195931
175acrosome assembly (GO:0001675)11.1257815
176cilium or flagellum-dependent cell motility (GO:0001539)10.9063802
177multicellular organism reproduction (GO:0032504)10.4662656
178binding of sperm to zona pellucida (GO:0007339)10.4267339
179axonemal dynein complex assembly (GO:0070286)10.2704657
180cell-cell recognition (GO:0009988)10.1282324

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.73831850
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.92570431
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.18010900
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.80912395
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.78439314
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.76255854
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.72253065
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.66041999
9FUS_26573619_Chip-Seq_HEK293_Human2.44393625
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.43326248
11GBX2_23144817_ChIP-Seq_PC3_Human2.38102762
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.36520461
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.36215685
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.35621858
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.33657742
16EWS_26573619_Chip-Seq_HEK293_Human2.24447967
17IGF1R_20145208_ChIP-Seq_DFB_Human2.24269493
18VDR_22108803_ChIP-Seq_LS180_Human2.22820226
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.22367742
20GATA1_26923725_Chip-Seq_HPCs_Mouse2.20113199
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.17344532
22* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.17062140
23ZNF274_21170338_ChIP-Seq_K562_Hela2.13183396
24P300_19829295_ChIP-Seq_ESCs_Human2.09630048
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.08928323
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00165277
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.2847159
28TAF15_26573619_Chip-Seq_HEK293_Human1.94668602
29ER_23166858_ChIP-Seq_MCF-7_Human1.93562901
30ELK1_19687146_ChIP-ChIP_HELA_Human1.90314625
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.89107208
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.88389083
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.87025907
34ELK4_26923725_Chip-Seq_MESODERM_Mouse1.86330818
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82366061
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.73522536
37FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72232956
38STAT1_17558387_ChIP-Seq_HELA_Human1.66613820
39KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.66306693
40TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.65018379
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59777791
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57819956
43BCAT_22108803_ChIP-Seq_LS180_Human1.57477766
44WDR5_24793694_ChIP-Seq_LNCAP_Human1.57244960
45SOX2_22085726_ChIP-Seq_NPCs_Mouse1.56500499
46* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56004536
47MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.55932006
48GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.52914475
49* SMAD4_21799915_ChIP-Seq_A2780_Human1.52804406
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52691571
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.49587481
52GATA3_21867929_ChIP-Seq_CD8_Mouse1.48656397
53VDR_23849224_ChIP-Seq_CD4+_Human1.48622736
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47151620
55AR_25329375_ChIP-Seq_VCAP_Human1.46427433
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45141980
57STAT3_23295773_ChIP-Seq_U87_Human1.43586838
58RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.42875369
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.40449510
60FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.39985869
61SOX2_19829295_ChIP-Seq_ESCs_Human1.38141554
62NANOG_19829295_ChIP-Seq_ESCs_Human1.38141554
63TCF4_22108803_ChIP-Seq_LS180_Human1.37683042
64KDM2B_26808549_Chip-Seq_REH_Human1.36954367
65TP53_22573176_ChIP-Seq_HFKS_Human1.34378201
66* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33934264
67REST_21632747_ChIP-Seq_MESCs_Mouse1.33148094
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32951968
69TCF4_23295773_ChIP-Seq_U87_Human1.32173923
70MYC_18940864_ChIP-ChIP_HL60_Human1.31395887
71* TAL1_26923725_Chip-Seq_HPCs_Mouse1.30786417
72LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.30405651
73P53_21459846_ChIP-Seq_SAOS-2_Human1.30375322
74KAP1_22055183_ChIP-Seq_ESCs_Mouse1.30336983
75PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.29766368
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.29698936
77SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.29560771
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27430402
79* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25718567
80* CBP_20019798_ChIP-Seq_JUKART_Human1.25718567
81CDX2_22108803_ChIP-Seq_LS180_Human1.25512070
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23288377
83NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.23235041
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.22929795
85FOXA1_25329375_ChIP-Seq_VCAP_Human1.20899490
86FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20899490
87E2F1_18555785_Chip-Seq_ESCs_Mouse1.20764072
88SUZ12_18555785_Chip-Seq_ESCs_Mouse1.20633398
89SRF_21415370_ChIP-Seq_HL-1_Mouse1.20319222
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.20010740
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19829921
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19811993
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19596033
94GATA3_21867929_ChIP-Seq_TH1_Mouse1.19514581
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.19357968
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18624007
97KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17602258
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17342212
99FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16873882
100RAD21_21589869_ChIP-Seq_MESCs_Mouse1.16234147
101IRF1_19129219_ChIP-ChIP_H3396_Human1.16226555
102RUNX2_22187159_ChIP-Seq_PCA_Human1.15658017
103PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15455835
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15357523
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15235961
106SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.15210718
107CBX2_27304074_Chip-Seq_ESCs_Mouse1.14504642
108* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13651889
109CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13493457
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13366541
111P300_18555785_Chip-Seq_ESCs_Mouse1.13252466
112GF1_26923725_Chip-Seq_HPCs_Mouse1.13102214
113SMAD4_21741376_ChIP-Seq_EPCs_Human1.12268062
114SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11947225
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11784590
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11784590
117CMYC_18555785_Chip-Seq_ESCs_Mouse1.11453623
118CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10966437
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10780566
120AR_20517297_ChIP-Seq_VCAP_Human1.10589529
121EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10224406
122SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09982235
123CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09872098
124EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07156792
125E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06841580
126RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06527800
127SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06356731
128SOX2_18555785_Chip-Seq_ESCs_Mouse1.05710251
129ERG_20517297_ChIP-Seq_VCAP_Human1.05431511
130PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05423031
131SPI1_26923725_Chip-Seq_HPCs_Mouse1.05243841
132PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05072443
133RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04711195
134PRDM14_20953172_ChIP-Seq_ESCs_Human1.04534661
135HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04329130
136RXRA_24833708_ChIP-Seq_LIVER_Mouse1.04318474
137FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04084034
138EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02505498
139YY1_22570637_ChIP-Seq_MALME-3M_Human1.02083083
140CRX_20693478_ChIP-Seq_RETINA_Mouse1.01172030
141TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00793888
142TET1_21451524_ChIP-Seq_MESCs_Mouse0.99497956
143GATA1_19941827_ChIP-Seq_MEL86_Mouse0.99403321
144* MYC_27129775_Chip-Seq_CORNEA_Mouse0.98507396
145ESET_19884257_ChIP-Seq_ESCs_Mouse0.98122778
146RARA_24833708_ChIP-Seq_LIVER_Mouse0.97344102
147NANOG_18555785_Chip-Seq_ESCs_Mouse0.97287515
148CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97118598
149PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96701620
150SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95764429
151ELF1_20517297_ChIP-Seq_JURKAT_Human0.95612254
152CTCF_20526341_ChIP-Seq_ESCs_Human0.93703415
153NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92961805
154OCT4_18555785_Chip-Seq_ESCs_Mouse0.91604455
155FLI1_21867929_ChIP-Seq_CD8_Mouse0.90476164
156MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90029191
157* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89108192
158P53_22387025_ChIP-Seq_ESCs_Mouse0.88960123
159SOX2_21211035_ChIP-Seq_LN229_Human0.88722714
160SOX11_22085726_ChIP-Seq_ESNs_Mouse0.88512232
161CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.87821008
162NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.87707177
163SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87391744
164NFYB_21822215_ChIP-Seq_K562_Human0.87318953
165JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.87304594
166* LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.86697688
167OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86251484
168PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85172613
169KLF4_18555785_Chip-Seq_ESCs_Mouse0.83266636
170EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.82944313
171NANOG_20526341_ChIP-Seq_ESCs_Human0.82550473

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.07665441
2MP0001929_abnormal_gametogenesis5.57904968
3MP0008877_abnormal_DNA_methylation4.69857126
4MP0000372_irregular_coat_pigmentation4.33566315
5MP0002210_abnormal_sex_determination3.57568265
6MP0002161_abnormal_fertility/fecundity3.31138796
7MP0003195_calcinosis3.26880981
8MP0001145_abnormal_male_reproductive3.01978851
9MP0005075_abnormal_melanosome_morpholog2.67972650
10MP0000653_abnormal_sex_gland2.61400163
11MP0005670_abnormal_white_adipose2.60468396
12MP0002653_abnormal_ependyma_morphology2.46017117
13MP0002938_white_spotting2.35717053
14MP0000015_abnormal_ear_pigmentation2.25273412
15MP0005084_abnormal_gallbladder_morpholo2.23138657
16MP0002837_dystrophic_cardiac_calcinosis2.18972265
17MP0006072_abnormal_retinal_apoptosis2.08152419
18MP0005410_abnormal_fertilization16.1475046
19MP0003136_yellow_coat_color1.91108765
20MP0002160_abnormal_reproductive_system1.90341530
21MP0002095_abnormal_skin_pigmentation1.89498151
22MP0002638_abnormal_pupillary_reflex1.84533760
23MP0005171_absent_coat_pigmentation1.83877862
24MP0000427_abnormal_hair_cycle1.83524491
25MP0005408_hypopigmentation1.83223324
26MP0003806_abnormal_nucleotide_metabolis1.80510919
27MP0003646_muscle_fatigue1.64608991
28MP0000371_diluted_coat_color1.54465175
29MP0000516_abnormal_urinary_system1.54388026
30MP0005367_renal/urinary_system_phenotyp1.54388026
31MP0004885_abnormal_endolymph1.46127729
32MP0005623_abnormal_meninges_morphology1.45501993
33MP0005645_abnormal_hypothalamus_physiol1.44019021
34MP0004233_abnormal_muscle_weight1.43276962
35MP0006292_abnormal_olfactory_placode1.42205623
36MP0002876_abnormal_thyroid_physiology1.42135376
37MP0008875_abnormal_xenobiotic_pharmacok1.35900098
38MP0002163_abnormal_gland_morphology1.32200851
39MP0010386_abnormal_urinary_bladder1.29701676
40MP0004142_abnormal_muscle_tone1.28198012
41MP0001485_abnormal_pinna_reflex1.27224400
42MP0002282_abnormal_trachea_morphology1.26025182
43MP0008872_abnormal_physiological_respon1.23261329
44MP0005379_endocrine/exocrine_gland_phen1.20016447
45MP0005646_abnormal_pituitary_gland1.16942500
46MP0010678_abnormal_skin_adnexa1.16180922
47MP0003718_maternal_effect1.13261050
48MP0000383_abnormal_hair_follicle1.12620887
49MP0003186_abnormal_redox_activity1.12436259
50MP0004147_increased_porphyrin_level1.10388593
51MP0003283_abnormal_digestive_organ1.09548795
52MP0001529_abnormal_vocalization1.09002100
53MP0003252_abnormal_bile_duct1.07338013
54MP0001968_abnormal_touch/_nociception1.06647211
55MP0002090_abnormal_vision1.04787337
56MP0001765_abnormal_ion_homeostasis1.04703571
57MP0001984_abnormal_olfaction1.03509255
58MP0005389_reproductive_system_phenotype0.96994187
59MP0000631_abnormal_neuroendocrine_gland0.96264158
60MP0001986_abnormal_taste_sensitivity0.95751368
61MP0008995_early_reproductive_senescence0.95502144
62MP0000647_abnormal_sebaceous_gland0.95433193
63MP0006054_spinal_hemorrhage0.94803259
64MP0009745_abnormal_behavioral_response0.94754507
65MP0001756_abnormal_urination0.94582371
66MP0002751_abnormal_autonomic_nervous0.94010241
67MP0005332_abnormal_amino_acid0.93904990
68MP0002277_abnormal_respiratory_mucosa0.93441877
69MP0006276_abnormal_autonomic_nervous0.91591920
70MP0002272_abnormal_nervous_system0.91516286
71MP0003880_abnormal_central_pattern0.91442098
72MP0001905_abnormal_dopamine_level0.91282565
73MP0005386_behavior/neurological_phenoty0.91123577
74MP0004924_abnormal_behavior0.91123577
75MP0001501_abnormal_sleep_pattern0.89901186
76MP0005647_abnormal_sex_gland0.89754548
77MP0001486_abnormal_startle_reflex0.87231937
78MP0000538_abnormal_urinary_bladder0.86741128
79MP0009780_abnormal_chondrocyte_physiolo0.86220870
80MP0008058_abnormal_DNA_repair0.85335349
81MP0005195_abnormal_posterior_eye0.83089047
82MP0008789_abnormal_olfactory_epithelium0.82459584
83MP0004215_abnormal_myocardial_fiber0.82007927
84MP0002557_abnormal_social/conspecific_i0.80072830
85MP0002234_abnormal_pharynx_morphology0.79557304
86MP0009046_muscle_twitch0.79154085
87MP0001944_abnormal_pancreas_morphology0.79104374
88MP0002693_abnormal_pancreas_physiology0.78583962
89MP0010094_abnormal_chromosome_stability0.75853695
90MP0003011_delayed_dark_adaptation0.73846842
91MP0003115_abnormal_respiratory_system0.71154533
92MP0000569_abnormal_digit_pigmentation0.63000243
93MP0003878_abnormal_ear_physiology0.62247729
94MP0005377_hearing/vestibular/ear_phenot0.62247729
95MP0009278_abnormal_bone_marrow0.61950638
96MP0005397_hematopoietic_system_phenotyp0.59387399
97MP0001545_abnormal_hematopoietic_system0.59387399
98MP0000358_abnormal_cell_content/0.57471908
99MP0005666_abnormal_adipose_tissue0.55323362
100MP0005636_abnormal_mineral_homeostasis0.52805531
101MP0003329_amyloid_beta_deposits0.51618239
102MP0002928_abnormal_bile_duct0.51220987
103MP0003699_abnormal_female_reproductive0.49939436
104MP0008057_abnormal_DNA_replication0.47745475
105MP0003879_abnormal_hair_cell0.47397762
106MP0001324_abnormal_eye_pigmentation0.46824376
107MP0009115_abnormal_fat_cell0.44733002
108MP0004036_abnormal_muscle_relaxation0.42412553
109MP0001764_abnormal_homeostasis0.41977140
110MP0003786_premature_aging0.41626144
111MP0003950_abnormal_plasma_membrane0.39752797
112MP0005253_abnormal_eye_physiology0.39699893
113MP0002269_muscular_atrophy0.39294582
114MP0003111_abnormal_nucleus_morphology0.38865770
115MP0001849_ear_inflammation0.37717643
116MP0000534_abnormal_ureter_morphology0.37559890
117MP0001293_anophthalmia0.37110123
118MP0008007_abnormal_cellular_replicative0.36202044
119MP0006036_abnormal_mitochondrial_physio0.35779455
120MP0005551_abnormal_eye_electrophysiolog0.35478522
121MP0005391_vision/eye_phenotype0.33945395
122MP0002971_abnormal_brown_adipose0.33146223
123MP0008961_abnormal_basal_metabolism0.32778959
124MP0001119_abnormal_female_reproductive0.31811232
125MP0004808_abnormal_hematopoietic_stem0.31333833
126MP0010307_abnormal_tumor_latency0.28748342
127MP0004811_abnormal_neuron_physiology0.28317952
128MP0001730_embryonic_growth_arrest0.28316319
129MP0003942_abnormal_urinary_system0.27682551
130MP0003787_abnormal_imprinting0.26289245
131MP0002102_abnormal_ear_morphology0.25544200
132MP0002736_abnormal_nociception_after0.25340998
133MP0001727_abnormal_embryo_implantation0.25130179
134MP0003861_abnormal_nervous_system0.24668442
135MP0000604_amyloidosis0.24398569
136MP0002152_abnormal_brain_morphology0.23773841
137MP0001661_extended_life_span0.23014376
138MP0006035_abnormal_mitochondrial_morpho0.22978426
139MP0004133_heterotaxia0.22658006
140MP0003633_abnormal_nervous_system0.22408751
141MP0002092_abnormal_eye_morphology0.22365316
142MP0004019_abnormal_vitamin_homeostasis0.22208375
143MP0002909_abnormal_adrenal_gland0.21191035
144MP0003948_abnormal_gas_homeostasis0.20496068
145MP0003959_abnormal_lean_body0.20431653
146MP0003045_fibrosis0.20369012
147MP0000313_abnormal_cell_death0.19709424
148MP0000751_myopathy0.19197442
149MP0002169_no_abnormal_phenotype0.19051022
150MP0002132_abnormal_respiratory_system0.19023257
151MP0002873_normal_phenotype0.18748988
152MP0004134_abnormal_chest_morphology0.18001638
153MP0005365_abnormal_bile_salt0.17748216
154MP0002139_abnormal_hepatobiliary_system0.17288286
155MP0003631_nervous_system_phenotype0.16862689
156MP0005375_adipose_tissue_phenotype0.16596001
157MP0004270_analgesia0.15985799
158MP0004043_abnormal_pH_regulation0.15887116
159MP0002970_abnormal_white_adipose0.15256647
160MP0002084_abnormal_developmental_patter0.15100007
161MP0004742_abnormal_vestibular_system0.14934837
162MP0002229_neurodegeneration0.14091064
163MP0002295_abnormal_pulmonary_circulatio0.13966537
164MP0003936_abnormal_reproductive_system0.13532168
165MP0005174_abnormal_tail_pigmentation0.13314361

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.28347170
2Abnormal respiratory epithelium morphology (HP:0012253)9.07284629
3Abnormal respiratory motile cilium morphology (HP:0005938)9.07284629
4Rhinitis (HP:0012384)7.69976766
5Chronic bronchitis (HP:0004469)7.36390504
6Abnormal ciliary motility (HP:0012262)7.28966815
7Infertility (HP:0000789)6.92529226
8Nasal polyposis (HP:0100582)6.49976451
9Abnormality of the nasal mucosa (HP:0000433)5.32105548
10Bronchiectasis (HP:0002110)4.61817637
11Bronchitis (HP:0012387)4.59150322
12Nephronophthisis (HP:0000090)4.42685393
13Male infertility (HP:0003251)4.27321082
14Pancreatic cysts (HP:0001737)3.90388570
15Pancreatic fibrosis (HP:0100732)3.57172985
16True hermaphroditism (HP:0010459)3.55281627
17Abnormal spermatogenesis (HP:0008669)3.41359517
18Recurrent otitis media (HP:0000403)3.36843800
19Abnormality of the renal medulla (HP:0100957)3.34054618
20Intestinal atresia (HP:0011100)3.24234040
21Recurrent sinusitis (HP:0011108)3.15979412
22Congenital stationary night blindness (HP:0007642)3.12601687
23Progressive macrocephaly (HP:0004481)2.98886376
24Tubulointerstitial nephritis (HP:0001970)2.92368586
25Acute necrotizing encephalopathy (HP:0006965)2.89681635
26Gonadotropin excess (HP:0000837)2.79529087
27Increased CSF lactate (HP:0002490)2.79116076
28Impulsivity (HP:0100710)2.76548830
29Hypothermia (HP:0002045)2.75572609
30Recurrent bronchitis (HP:0002837)2.74323534
31Aplasia/Hypoplasia of the fovea (HP:0008060)2.74004914
32Hypoplasia of the fovea (HP:0007750)2.74004914
33Methylmalonic acidemia (HP:0002912)2.73957737
34Mitochondrial inheritance (HP:0001427)2.73785333
35Tubular atrophy (HP:0000092)2.67809712
36Type II lissencephaly (HP:0007260)2.61671904
37Acute encephalopathy (HP:0006846)2.56894982
38Molar tooth sign on MRI (HP:0002419)2.56299015
39Abnormality of midbrain morphology (HP:0002418)2.56299015
40Tubulointerstitial abnormality (HP:0001969)2.49688308
41Attenuation of retinal blood vessels (HP:0007843)2.48990727
42Nephrogenic diabetes insipidus (HP:0009806)2.47938407
43Hepatic necrosis (HP:0002605)2.47475901
44Abnormality of the fovea (HP:0000493)2.46434268
45Albinism (HP:0001022)2.44977505
46Renal cortical cysts (HP:0000803)2.40446761
47Medial flaring of the eyebrow (HP:0010747)2.40133253
48Hepatocellular necrosis (HP:0001404)2.37845243
49Abnormality of the lower motor neuron (HP:0002366)2.36507875
50Thyroiditis (HP:0100646)2.35085346
51Abnormal mitochondria in muscle tissue (HP:0008316)2.33345953
52Azoospermia (HP:0000027)2.32989027
53Hyperinsulinemic hypoglycemia (HP:0000825)2.32837310
54Neoplasm of the adrenal cortex (HP:0100641)2.30963334
55Large for gestational age (HP:0001520)2.30883968
56Cholecystitis (HP:0001082)2.29782411
57Abnormal gallbladder physiology (HP:0012438)2.29782411
58Chronic hepatic failure (HP:0100626)2.28218778
59Ketoacidosis (HP:0001993)2.27754748
60Hypoglycemic coma (HP:0001325)2.26393297
61Pancreatic islet-cell hyperplasia (HP:0004510)2.25968166
62Volvulus (HP:0002580)2.23704798
63Congenital, generalized hypertrichosis (HP:0004540)2.22508064
64Hyperventilation (HP:0002883)2.20239084
65Abnormal rod and cone electroretinograms (HP:0008323)2.18861452
66Aplasia/Hypoplasia of the tongue (HP:0010295)2.17537360
67Renal Fanconi syndrome (HP:0001994)2.15453151
68Methylmalonic aciduria (HP:0012120)2.13658551
69Furrowed tongue (HP:0000221)2.13023452
70Abolished electroretinogram (ERG) (HP:0000550)2.12884182
71Disproportionate short-trunk short stature (HP:0003521)2.11739896
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.09421437
73Congenital sensorineural hearing impairment (HP:0008527)2.07459775
74Hypoglycemic seizures (HP:0002173)2.06891173
75Genital tract atresia (HP:0001827)2.04629218
76Increased hepatocellular lipid droplets (HP:0006565)2.03555510
77Tubulointerstitial fibrosis (HP:0005576)2.01816514
78Gaze-evoked nystagmus (HP:0000640)2.00823417
79Aplasia/Hypoplasia of the tibia (HP:0005772)2.00568898
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.0837578
81Absent/shortened dynein arms (HP:0200106)13.0797836
82Dynein arm defect of respiratory motile cilia (HP:0012255)13.0797836
83Abnormality of vitamin B metabolism (HP:0004340)1.99156898
84Astigmatism (HP:0000483)1.98278012
85Male pseudohermaphroditism (HP:0000037)1.96210432
86Fibular hypoplasia (HP:0003038)1.95169327
87Postaxial foot polydactyly (HP:0001830)1.95109308
88Anencephaly (HP:0002323)1.94121969
89Abnormality of the ileum (HP:0001549)1.94104783
90Hypoplasia of the capital femoral epiphysis (HP:0003090)1.93670031
91Vaginal atresia (HP:0000148)1.93474468
92Stage 5 chronic kidney disease (HP:0003774)1.93353712
93Aplasia/Hypoplasia of the macula (HP:0008059)1.92637323
94Lipid accumulation in hepatocytes (HP:0006561)1.92549875
95Optic disc pallor (HP:0000543)1.91993490
96Meckel diverticulum (HP:0002245)1.90329547
97Spastic tetraparesis (HP:0001285)1.90249549
98Sclerocornea (HP:0000647)1.88385309
99Dyschromatopsia (HP:0007641)1.88314179
100Pendular nystagmus (HP:0012043)1.87186123
101Polyuria (HP:0000103)1.86690119
102Exertional dyspnea (HP:0002875)1.86346142
103Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85942786
104Heterotopia (HP:0002282)1.85441278
105Amyotrophic lateral sclerosis (HP:0007354)1.84724680
106Ketosis (HP:0001946)1.84604765
107Cerebral edema (HP:0002181)1.84509638
108Progressive inability to walk (HP:0002505)1.81971976
109Abnormality of urine glucose concentration (HP:0011016)1.81742379
110Glycosuria (HP:0003076)1.81742379
111Patchy hypopigmentation of hair (HP:0011365)1.80168590
112Preaxial hand polydactyly (HP:0001177)1.79566197
113Polydipsia (HP:0001959)1.79465290
114Abnormal drinking behavior (HP:0030082)1.79465290
1153-Methylglutaconic aciduria (HP:0003535)1.77790835
116Choroideremia (HP:0001139)1.77664496
117Increased serum lactate (HP:0002151)1.77259837
118Hypomagnesemia (HP:0002917)1.77043458
119Short tibia (HP:0005736)1.77023488
120Gastrointestinal atresia (HP:0002589)1.76984223
121Aplasia/Hypoplasia affecting the retina (HP:0008061)1.76728336
122Short ribs (HP:0000773)1.75585824
123Hyperglycinemia (HP:0002154)1.74910291
124Abnormality of the renal cortex (HP:0011035)1.74711709
125Congenital hepatic fibrosis (HP:0002612)1.74233552
126Poor coordination (HP:0002370)1.73021929
127Abnormality of chromosome stability (HP:0003220)1.72938309
128Bell-shaped thorax (HP:0001591)1.64862409
129Oculomotor apraxia (HP:0000657)1.63462712
130Decreased central vision (HP:0007663)1.62058610
131Abnormality of dentin (HP:0010299)1.59447867
132Abnormality of renal excretion (HP:0011036)1.59063533
133Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.58958455
134Absent epiphyses (HP:0010577)1.58958455
135Renal dysplasia (HP:0000110)1.56936405
136Abnormal biliary tract physiology (HP:0012439)1.56556592
137Bile duct proliferation (HP:0001408)1.56556592
138Abnormality of the dental root (HP:0006486)1.55357870
139Taurodontia (HP:0000679)1.55357870
140Abnormality of permanent molar morphology (HP:0011071)1.55357870
141Impaired proprioception (HP:0010831)1.54882595
142Postaxial hand polydactyly (HP:0001162)1.49765130
143Absent frontal sinuses (HP:0002688)1.47561733
144Hemorrhage of the eye (HP:0011885)1.44431976
145Abnormality of the dental pulp (HP:0006479)1.43986060
146Facial cleft (HP:0002006)1.43834364
147J-shaped sella turcica (HP:0002680)1.43653549
148Deformed sella turcica (HP:0002681)1.42944673
149Abnormality of molar (HP:0011077)1.42184586
150Abnormality of molar morphology (HP:0011070)1.42184586
151Neurofibrillary tangles (HP:0002185)1.40900295
152Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.40459536
153Chronic sinusitis (HP:0011109)1.40246167
154Aplasia/Hypoplasia of the lens (HP:0008063)1.39898632
155Short thorax (HP:0010306)1.38463719
156Cystic liver disease (HP:0006706)1.32762878
157Abnormal urine output (HP:0012590)1.30893116
158Broad distal phalanx of finger (HP:0009836)1.29989263
159Short femoral neck (HP:0100864)1.28815107
160Asymmetric septal hypertrophy (HP:0001670)1.28741379
161Easy fatigability (HP:0003388)1.28614188
162Loss of speech (HP:0002371)1.28597992
163Nephropathy (HP:0000112)1.27531168
164Decreased electroretinogram (ERG) amplitude (HP:0000654)1.26451343
165Congenital malformation of the right heart (HP:0011723)1.25282504
166Double outlet right ventricle (HP:0001719)1.25282504
167Congenital primary aphakia (HP:0007707)1.24394628
168Hemiparesis (HP:0001269)1.24347896
169Microglossia (HP:0000171)1.24150185
170Gait imbalance (HP:0002141)1.23920129
171Cerebellar dysplasia (HP:0007033)1.23223148
172Truncal obesity (HP:0001956)1.22752954
173Abnormality of ocular smooth pursuit (HP:0000617)1.21826252
174Supernumerary spleens (HP:0009799)1.20652317
175Bundle branch block (HP:0011710)1.19284434
176Aplasia/Hypoplasia of the fibula (HP:0006492)1.19007398
177Exercise-induced myalgia (HP:0003738)1.16295703
178Median cleft lip (HP:0000161)1.16213133
179Cerebral inclusion bodies (HP:0100314)1.15091374

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.21572292
2PDK38.21572292
3TESK16.28735593
4FRK5.74308812
5PDK25.30506839
6PRKD34.96657397
7ICK4.33480125
8INSRR3.00191393
9MAP4K22.90651188
10NUAK12.50194281
11TNIK2.39529853
12PTK2B2.34543793
13WNK42.21509504
14EIF2AK32.19737715
15ACVR1B2.18821437
16PNCK2.13831389
17TRIM282.12729187
18ZAK2.06675110
19STK391.97895862
20ERBB31.91582332
21MST41.89965082
22NEK21.82226642
23PLK21.76304918
24STK381.75572055
25GRK11.70454758
26ADRBK21.60116600
27MKNK21.59915455
28PLK31.54862229
29DYRK1B1.46018468
30CASK1.39840939
31FGFR21.39569727
32PAK31.39516777
33MAPK131.31518956
34EIF2AK11.30703548
35OXSR11.25364401
36TLK11.24869360
37FER1.17182838
38STK161.11937870
39PDK11.09220313
40MAPK151.07097010
41VRK11.02394219
42TXK1.00890506
43VRK20.97096930
44MAP3K40.94547193
45TYRO30.93613906
46BUB10.93076010
47WNK10.91413053
48BCR0.89408101
49PHKG20.89278651
50PHKG10.89278651
51CAMK1G0.89003862
52ADRBK10.86110439
53TAF10.85819051
54MKNK10.85287125
55TAOK30.84626619
56DYRK30.83888619
57PASK0.81262923
58PRKCE0.81094460
59CSNK1G10.80321253
60IRAK10.76739306
61CCNB10.75303843
62CSNK1G20.73025659
63TGFBR10.72923237
64MAP3K120.72132102
65BMPR20.71521281
66STK30.70547692
67CSNK1G30.69483733
68EIF2AK20.67370367
69TIE10.66997952
70EEF2K0.66353449
71TESK20.65076394
72BCKDK0.63249350
73RIPK40.62736599
74NEK10.62408106
75NLK0.62083059
76PDPK10.60212186
77TTK0.59719582
78FLT30.58429510
79PINK10.58266054
80GRK50.57769687
81TSSK60.56116115
82OBSCN0.54986342
83CHEK20.51737214
84PRKCI0.50509443
85CSNK1A1L0.49239790
86EPHA40.49075304
87CAMKK10.47631140
88TEC0.47615095
89NTRK20.47463845
90SIK30.47159420
91CDC70.46898039
92PRKAA20.45957544
93MAP2K70.45792113
94TRPM70.45501645
95CDK30.45422299
96CHEK10.42703787
97AKT30.42557905
98NME10.41750518
99LMTK20.39295086
100MAP2K60.38384533
101DYRK20.37743318
102TNK20.36820318
103IRAK20.36779449
104MAP3K20.36627109
105STK40.36517948
106MUSK0.35150450
107ATR0.33760930
108PAK10.33275105
109IKBKB0.32003144
110CSNK1A10.31823761
111PKN10.31816109
112MTOR0.31671069
113DAPK20.30724788
114ATM0.30191595
115ROCK10.29690491
116WEE10.29555503
117MAPKAPK30.29012926
118PRKACA0.28839231
119MARK20.28132145
120IGF1R0.28122610
121PRKCG0.28049145
122PAK20.28037384
123CDK120.27503549
124STK38L0.26838957
125MAP3K100.24468260
126PRKAA10.23040228
127PLK40.21907762
128MAPKAPK50.21881500
129WNK30.20225365
130CAMKK20.18164307
131PAK40.16288857
132RPS6KB10.15783271
133PLK10.13257117
134BRSK20.12585929
135PRKCZ0.12418071
136PRKCQ0.11936174
137NEK60.10176917
138MARK30.09106246
139BRAF0.08822030
140STK100.08804293
141CDK150.08790692
142CDK180.06877344
143BRSK10.06782958
144RPS6KA10.06583928
145GSK3B0.05585047
146CAMK1D0.04995326
147CDK11A0.04989411
148STK110.04497865
149PDGFRB0.04081908
150CDK20.03341622
151PAK60.03310936
152CDK60.02705300
153CDK10.02518432
154CSNK1D0.02477714
155CSNK2A10.02420849
156CDK140.02129141
157MAPK80.02094998
158YES10.01756935
159PRKACG0.01569948
160CSF1R0.01342372
161PRKG10.00585973
162ZAP700.00530727
163AURKA-0.0295584
164PRKCA-0.0261947
165TAOK1-0.0244165
166PIM1-0.0225686
167CDK4-0.0221210
168CSK-0.0201361
169EGFR-0.0197626
170RPS6KA3-0.0189446
171CLK1-0.0103984
172BMPR1B-0.0090501
173PRKDC-0.0065628
174PRKCB-0.0048654
175CAMK2A-0.0042589
176PRKG2-0.0014725

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.30668384
2Fatty acid biosynthesis_Homo sapiens_hsa000614.25267872
3Vitamin B6 metabolism_Homo sapiens_hsa007503.66712110
4Pyruvate metabolism_Homo sapiens_hsa006203.65272066
5Protein export_Homo sapiens_hsa030603.59668677
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.00887161
7Proteasome_Homo sapiens_hsa030502.93154508
8Linoleic acid metabolism_Homo sapiens_hsa005912.88522955
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.82446216
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.81192130
11Glucagon signaling pathway_Homo sapiens_hsa049222.75391865
12Propanoate metabolism_Homo sapiens_hsa006402.62581471
13Oxidative phosphorylation_Homo sapiens_hsa001902.61192268
14Homologous recombination_Homo sapiens_hsa034402.53570947
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.50626352
16Selenocompound metabolism_Homo sapiens_hsa004502.35132653
17Basal transcription factors_Homo sapiens_hsa030222.34125748
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.33449165
19Carbohydrate digestion and absorption_Homo sapiens_hsa049732.30685761
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.26810670
21Non-homologous end-joining_Homo sapiens_hsa034502.25856957
22Butanoate metabolism_Homo sapiens_hsa006502.25252193
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.23234191
24Dorso-ventral axis formation_Homo sapiens_hsa043202.20741703
25Phototransduction_Homo sapiens_hsa047442.11431969
26Glycerolipid metabolism_Homo sapiens_hsa005612.08040900
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.06077358
28RNA polymerase_Homo sapiens_hsa030202.05382855
29Parkinsons disease_Homo sapiens_hsa050122.01299649
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.01209592
31Oocyte meiosis_Homo sapiens_hsa041141.82286338
32PPAR signaling pathway_Homo sapiens_hsa033201.79063477
33RNA degradation_Homo sapiens_hsa030181.76270593
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.68363728
35Amphetamine addiction_Homo sapiens_hsa050311.65776664
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.64799640
37Fanconi anemia pathway_Homo sapiens_hsa034601.64400200
38Pentose phosphate pathway_Homo sapiens_hsa000301.64008086
39Nitrogen metabolism_Homo sapiens_hsa009101.61841627
40Fructose and mannose metabolism_Homo sapiens_hsa000511.59229677
41Tryptophan metabolism_Homo sapiens_hsa003801.58352241
42Regulation of autophagy_Homo sapiens_hsa041401.55558232
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.55338317
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.53052486
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.51776126
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.40867745
47Caffeine metabolism_Homo sapiens_hsa002321.40050033
48Fat digestion and absorption_Homo sapiens_hsa049751.39632401
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39226102
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.38639593
51Fatty acid elongation_Homo sapiens_hsa000621.30734420
52Ether lipid metabolism_Homo sapiens_hsa005651.30355267
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29525187
54Peroxisome_Homo sapiens_hsa041461.29008156
55Antigen processing and presentation_Homo sapiens_hsa046121.25454910
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25117407
57Mineral absorption_Homo sapiens_hsa049781.24595540
58Fatty acid metabolism_Homo sapiens_hsa012121.24560453
59Alzheimers disease_Homo sapiens_hsa050101.23308425
60Carbon metabolism_Homo sapiens_hsa012001.23078732
61Cardiac muscle contraction_Homo sapiens_hsa042601.22082168
62Renin secretion_Homo sapiens_hsa049241.21439829
63Fatty acid degradation_Homo sapiens_hsa000711.18140376
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16454829
65Huntingtons disease_Homo sapiens_hsa050161.16348156
66Cysteine and methionine metabolism_Homo sapiens_hsa002701.15814548
67Primary bile acid biosynthesis_Homo sapiens_hsa001201.15034798
68mRNA surveillance pathway_Homo sapiens_hsa030151.12029037
69Circadian rhythm_Homo sapiens_hsa047101.11479699
70Mismatch repair_Homo sapiens_hsa034301.11022344
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10305518
72One carbon pool by folate_Homo sapiens_hsa006701.09755114
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02660443
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97296838
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96989887
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93990819
77Long-term potentiation_Homo sapiens_hsa047200.92771977
78RNA transport_Homo sapiens_hsa030130.92310108
79Retinol metabolism_Homo sapiens_hsa008300.89659036
80Purine metabolism_Homo sapiens_hsa002300.87611169
81beta-Alanine metabolism_Homo sapiens_hsa004100.87074120
82Glutathione metabolism_Homo sapiens_hsa004800.84966356
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83778526
84Collecting duct acid secretion_Homo sapiens_hsa049660.82948992
85Hedgehog signaling pathway_Homo sapiens_hsa043400.82327667
86Estrogen signaling pathway_Homo sapiens_hsa049150.82071198
87Olfactory transduction_Homo sapiens_hsa047400.80046447
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79025861
89p53 signaling pathway_Homo sapiens_hsa041150.78712345
90Nucleotide excision repair_Homo sapiens_hsa034200.78115771
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77811677
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77684333
93Insulin secretion_Homo sapiens_hsa049110.77309579
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77063384
95Folate biosynthesis_Homo sapiens_hsa007900.75654749
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.75433298
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74478286
98ABC transporters_Homo sapiens_hsa020100.72884714
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72482767
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71479176
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.69962933
102Arachidonic acid metabolism_Homo sapiens_hsa005900.69767978
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.69144883
104Biosynthesis of amino acids_Homo sapiens_hsa012300.68463862
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.68040971
106Chemical carcinogenesis_Homo sapiens_hsa052040.67427608
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65082757
108Thyroid hormone synthesis_Homo sapiens_hsa049180.62412521
109Steroid biosynthesis_Homo sapiens_hsa001000.62369738
110Systemic lupus erythematosus_Homo sapiens_hsa053220.62331108
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60338563
112Type I diabetes mellitus_Homo sapiens_hsa049400.59995373
113Legionellosis_Homo sapiens_hsa051340.59240435
114Ovarian steroidogenesis_Homo sapiens_hsa049130.58499947
115Bile secretion_Homo sapiens_hsa049760.56913118
116Calcium signaling pathway_Homo sapiens_hsa040200.55906672
117Nicotine addiction_Homo sapiens_hsa050330.55806128
118Asthma_Homo sapiens_hsa053100.54623694
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52869156
120Salivary secretion_Homo sapiens_hsa049700.51981404
121AMPK signaling pathway_Homo sapiens_hsa041520.51825344
122Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51714264
123Endocytosis_Homo sapiens_hsa041440.48295067
124VEGF signaling pathway_Homo sapiens_hsa043700.48061099
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.44604902
126Synaptic vesicle cycle_Homo sapiens_hsa047210.44450709
127Inositol phosphate metabolism_Homo sapiens_hsa005620.43784030
128Base excision repair_Homo sapiens_hsa034100.43372716
129Pancreatic secretion_Homo sapiens_hsa049720.42761187
130Renin-angiotensin system_Homo sapiens_hsa046140.42401377
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39931027
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39787408
133Tyrosine metabolism_Homo sapiens_hsa003500.39457646
134Protein digestion and absorption_Homo sapiens_hsa049740.38976041
135Lysine degradation_Homo sapiens_hsa003100.38410040
136Alcoholism_Homo sapiens_hsa050340.38108495
137Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35754397
138Circadian entrainment_Homo sapiens_hsa047130.33667884
139Sphingolipid metabolism_Homo sapiens_hsa006000.33181188
140Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33148572
141Serotonergic synapse_Homo sapiens_hsa047260.32949006
142Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32665786
143Gastric acid secretion_Homo sapiens_hsa049710.31786875
144Rheumatoid arthritis_Homo sapiens_hsa053230.31438548
145Taste transduction_Homo sapiens_hsa047420.30391712
146Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30082771
147cAMP signaling pathway_Homo sapiens_hsa040240.29263831
148Metabolic pathways_Homo sapiens_hsa011000.28170210
149N-Glycan biosynthesis_Homo sapiens_hsa005100.24174682
150Cocaine addiction_Homo sapiens_hsa050300.23896526
151Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18765901
152Pyrimidine metabolism_Homo sapiens_hsa002400.17283175
153Wnt signaling pathway_Homo sapiens_hsa043100.17249136
154Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.16344964
155Sulfur metabolism_Homo sapiens_hsa009200.16251066
156T cell receptor signaling pathway_Homo sapiens_hsa046600.15555207
157B cell receptor signaling pathway_Homo sapiens_hsa046620.15008387
158Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.14329220
159Viral carcinogenesis_Homo sapiens_hsa052030.14157425
160Type II diabetes mellitus_Homo sapiens_hsa049300.13625829
161Salmonella infection_Homo sapiens_hsa051320.11550845

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