XRN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K4 trimethylation (GO:0080182)3.87028167
2cellular response to ethanol (GO:0071361)3.80664169
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.77880827
4microglial cell activation (GO:0001774)3.74745496
5detection of molecule of bacterial origin (GO:0032490)3.69688291
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.64908002
7positive regulation of gamma-delta T cell activation (GO:0046645)3.64684689
8positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.64361087
9establishment of protein localization to Golgi (GO:0072600)3.62454069
10macrophage activation involved in immune response (GO:0002281)3.52388120
11negative regulation of translation, ncRNA-mediated (GO:0040033)3.50788824
12regulation of translation, ncRNA-mediated (GO:0045974)3.50788824
13negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.50788824
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.47750398
15protein targeting to Golgi (GO:0000042)3.43451388
16interferon-gamma production (GO:0032609)3.39484036
17positive regulation of granulocyte differentiation (GO:0030854)3.33364689
18positive T cell selection (GO:0043368)3.31289750
19antigen processing and presentation of endogenous antigen (GO:0019883)3.26090204
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.23598161
21negative regulation of cell killing (GO:0031342)3.23598161
22negative regulation of interleukin-12 production (GO:0032695)3.23036306
23regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.22392102
24retrograde transport, vesicle recycling within Golgi (GO:0000301)3.21091807
25negative T cell selection (GO:0043383)3.19355296
26regulation of interferon-beta biosynthetic process (GO:0045357)3.18532628
27regulation of regulatory T cell differentiation (GO:0045589)3.12960628
28regulation of DNA endoreduplication (GO:0032875)3.07973070
29cytoplasmic mRNA processing body assembly (GO:0033962)3.05949494
30histone H3-K36 demethylation (GO:0070544)3.02333831
31B cell receptor signaling pathway (GO:0050853)3.01912861
32hepatocyte apoptotic process (GO:0097284)3.01770633
33CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.00635168
34negative regulation of lymphocyte mediated immunity (GO:0002707)2.99176045
35interferon-gamma-mediated signaling pathway (GO:0060333)2.98820160
36macrophage activation (GO:0042116)2.97713716
37mitotic sister chromatid cohesion (GO:0007064)2.96069244
38T cell selection (GO:0045058)2.94252719
39cellular extravasation (GO:0045123)2.94220741
40alpha-beta T cell differentiation (GO:0046632)2.89024181
41neutrophil mediated immunity (GO:0002446)2.86386727
42detection of external biotic stimulus (GO:0098581)2.84994744
43negative regulation of B cell proliferation (GO:0030889)2.84719460
44negative thymic T cell selection (GO:0045060)2.83635087
45negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.82834685
46alpha-beta T cell activation (GO:0046631)2.81746398
47regulation of MHC class I biosynthetic process (GO:0045343)2.81177950
48positive regulation by symbiont of host defense response (GO:0052509)2.80176661
49modulation by symbiont of host defense response (GO:0052031)2.80176661
50modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.80176661
51modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.80176661
52positive regulation by organism of defense response of other organism involved in symbiotic interact2.80176661
53modulation by symbiont of host immune response (GO:0052553)2.80176661
54myeloid leukocyte mediated immunity (GO:0002444)2.79462660
55neural tube formation (GO:0001841)2.73155593
56protein K11-linked deubiquitination (GO:0035871)2.72799796
57positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.72739492
58positive regulation of toll-like receptor signaling pathway (GO:0034123)2.72084935
59CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.71987737
60T-helper cell differentiation (GO:0042093)2.71987737
61positive regulation of tolerance induction (GO:0002645)2.69780518
62tolerance induction (GO:0002507)2.68616383
63regulation of T cell tolerance induction (GO:0002664)2.68077713
64monoubiquitinated protein deubiquitination (GO:0035520)2.67842603
65histone H3-K4 methylation (GO:0051568)2.67295380
66CD4-positive, alpha-beta T cell activation (GO:0035710)2.67223789
67regulation of interleukin-12 biosynthetic process (GO:0045075)2.67206844
68peptidyl-lysine trimethylation (GO:0018023)2.66640590
69negative regulation of adaptive immune response (GO:0002820)2.65167129
70positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.63716048
71regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.61115063
72positive regulation of defense response to virus by host (GO:0002230)2.60986573
73positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.60225599
74natural killer cell activation involved in immune response (GO:0002323)2.59913286
75regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.59502479
76neutrophil activation (GO:0042119)2.59253289
77positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.59061248
78regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.59061248
79regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.58069903
80positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.58069903
81regulation of tolerance induction (GO:0002643)2.56873099
82production of molecular mediator involved in inflammatory response (GO:0002532)2.56420773
83defense response to protozoan (GO:0042832)2.54863175
84histone H3-K9 demethylation (GO:0033169)2.54537118
85cellular response to exogenous dsRNA (GO:0071360)2.54423486
86macroautophagy (GO:0016236)2.54303249
87myeloid cell activation involved in immune response (GO:0002275)2.53836775
88JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.52957520
89regulation of alpha-beta T cell proliferation (GO:0046640)2.52745420
90response to interferon-alpha (GO:0035455)2.52685997
91I-kappaB phosphorylation (GO:0007252)2.50992584
92positive regulation of mRNA catabolic process (GO:0061014)2.49716215
93cellular response to interleukin-15 (GO:0071350)2.48991894
94response to host defenses (GO:0052200)2.48253734
95regulation of protein polyubiquitination (GO:1902914)2.48106575
96V(D)J recombination (GO:0033151)2.48089112
97regulation of gamma-delta T cell activation (GO:0046643)2.45371590
98histone H3-K9 methylation (GO:0051567)2.43089641
99detection of other organism (GO:0098543)2.42447749
100B cell proliferation (GO:0042100)2.40734529
101granulocyte activation (GO:0036230)2.37658000
102response to type I interferon (GO:0034340)2.36937150
103positive thymic T cell selection (GO:0045059)2.35692372
104T cell differentiation involved in immune response (GO:0002292)2.33972610
105alpha-beta T cell differentiation involved in immune response (GO:0002293)2.33972610
106alpha-beta T cell activation involved in immune response (GO:0002287)2.33972610
107dendritic cell chemotaxis (GO:0002407)2.32848178
108nuclear pore complex assembly (GO:0051292)2.32717391
109dendritic cell migration (GO:0036336)2.30692884
110cellular response to type I interferon (GO:0071357)2.30161911
111type I interferon signaling pathway (GO:0060337)2.30161911
112positive regulation of interleukin-2 production (GO:0032743)2.29750611
113response to muramyl dipeptide (GO:0032495)2.29270505
114activated T cell proliferation (GO:0050798)2.28256360
115regulation of B cell receptor signaling pathway (GO:0050855)2.28014137
116response to host immune response (GO:0052572)2.27665028
117response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.27665028
118definitive hemopoiesis (GO:0060216)2.27237158
119T cell migration (GO:0072678)2.26367224
120positive regulation of cellular amide metabolic process (GO:0034250)2.26218147
121cellular response to interferon-alpha (GO:0035457)2.26196209
122germinal center formation (GO:0002467)2.26170846
123phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.26104122
124negative regulation of DNA-dependent DNA replication (GO:2000104)2.24986863
125positive regulation of interferon-alpha production (GO:0032727)2.24140971
126thymic T cell selection (GO:0045061)2.22310833
127regulation of activation of Janus kinase activity (GO:0010533)2.21828189
128regulation of gamma-delta T cell differentiation (GO:0045586)2.20373045
129T cell differentiation (GO:0030217)2.19083650
130positive regulation of interleukin-12 production (GO:0032735)2.18843738
131modulation by symbiont of host cellular process (GO:0044068)2.18837644
132T-helper 1 type immune response (GO:0042088)2.17962799
133replicative senescence (GO:0090399)2.17480008
134regulation of mRNA catabolic process (GO:0061013)2.16913009
135positive regulation of alpha-beta T cell proliferation (GO:0046641)2.16630641
136regulation of interferon-alpha production (GO:0032647)2.15762003
137histone lysine demethylation (GO:0070076)2.15681996
138negative regulation of T cell mediated immunity (GO:0002710)2.13345819
139mesenchymal cell differentiation involved in kidney development (GO:0072161)2.12818407
140mesenchymal cell differentiation involved in renal system development (GO:2001012)2.12818407
141regulation of germinal center formation (GO:0002634)2.12633399
142response to interleukin-15 (GO:0070672)2.12213869
143positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.11978677
144histone H3-K9 modification (GO:0061647)2.11854244
145histone lysine methylation (GO:0034968)2.11080945
146B cell homeostasis (GO:0001782)2.10016286
147positive regulation of interferon-beta production (GO:0032728)2.09334376
148interkinetic nuclear migration (GO:0022027)2.08868094
149modulation by virus of host process (GO:0019054)2.08441506
150mesenchymal cell differentiation (GO:0048762)2.07932847

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.58617892
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.11566658
3SMAD_19615063_ChIP-ChIP_OVARY_Human2.90358438
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.88286391
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.88262578
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.76297259
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.49519079
8GBX2_23144817_ChIP-Seq_PC3_Human2.41543881
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.34403346
10GATA1_22025678_ChIP-Seq_K562_Human2.31694750
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.31430197
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.30211408
13* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29520753
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23842628
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.09420056
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.08190985
17* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.06994799
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.01925682
19TP63_19390658_ChIP-ChIP_HaCaT_Human1.95876862
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94426808
21IGF1R_20145208_ChIP-Seq_DFB_Human1.87397816
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82019769
23* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74585983
24TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.72811610
25FUS_26573619_Chip-Seq_HEK293_Human1.71055340
26NANOG_18555785_Chip-Seq_ESCs_Mouse1.70483160
27RUNX_20019798_ChIP-Seq_JUKART_Human1.65087820
28EWS_26573619_Chip-Seq_HEK293_Human1.64548066
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.62757669
30E2F1_18555785_Chip-Seq_ESCs_Mouse1.62020734
31* P300_19829295_ChIP-Seq_ESCs_Human1.60119616
32AR_21572438_ChIP-Seq_LNCaP_Human1.58623737
33MYB_26560356_Chip-Seq_TH2_Human1.58581276
34NFE2_27457419_Chip-Seq_LIVER_Mouse1.58179586
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.56185359
36EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.51301928
37* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49682543
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48892486
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.48583353
40SUZ12_18555785_Chip-Seq_ESCs_Mouse1.47135051
41TAF15_26573619_Chip-Seq_HEK293_Human1.46761268
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.46421149
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46351848
44P53_22387025_ChIP-Seq_ESCs_Mouse1.44845796
45TP53_16413492_ChIP-PET_HCT116_Human1.44821124
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44540925
47SCL_19346495_ChIP-Seq_HPC-7_Human1.44448703
48SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44202855
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.44019806
50SMAD4_21799915_ChIP-Seq_A2780_Human1.43295952
51E2F7_22180533_ChIP-Seq_HELA_Human1.42901972
52PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42699226
53CMYC_18555785_Chip-Seq_ESCs_Mouse1.40832029
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.40586334
55GATA3_26560356_Chip-Seq_TH2_Human1.39016962
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38536644
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.37245035
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35810936
59NMYC_18555785_Chip-Seq_ESCs_Mouse1.35304930
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35211856
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35211856
62EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.33706141
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.32206559
64STAT3_18555785_Chip-Seq_ESCs_Mouse1.30218091
65GATA3_27048872_Chip-Seq_THYMUS_Human1.29934710
66P300_18555785_Chip-Seq_ESCs_Mouse1.29301044
67MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27249780
68OCT4_18555785_Chip-Seq_ESCs_Mouse1.26299621
69FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26193933
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26185729
71ER_23166858_ChIP-Seq_MCF-7_Human1.26006943
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.25797675
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24975003
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24159491
75* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22358679
76SOX2_18555785_Chip-Seq_ESCs_Mouse1.21104028
77* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.20220382
78TCF4_18268006_ChIP-ChIP_LS174T_Human1.19741998
79STAT3_23295773_ChIP-Seq_U87_Human1.18855629
80AHR_22903824_ChIP-Seq_MCF-7_Human1.17642919
81VDR_22108803_ChIP-Seq_LS180_Human1.17112419
82* MYB_26560356_Chip-Seq_TH1_Human1.16527129
83ZNF274_21170338_ChIP-Seq_K562_Hela1.16164938
84PU1_27457419_Chip-Seq_LIVER_Mouse1.16085646
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.15439988
86RUNX1_27457419_Chip-Seq_LIVER_Mouse1.15004994
87TP53_18474530_ChIP-ChIP_U2OS_Human1.14558205
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.14275071
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13908532
90ZFX_18555785_Chip-Seq_ESCs_Mouse1.13835888
91* TCF4_23295773_ChIP-Seq_U87_Human1.12554725
92POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11160818
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.10740171
94CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10617135
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10514473
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10363394
97* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10003313
98* CBP_20019798_ChIP-Seq_JUKART_Human1.09503120
99* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09503120
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08980069
101CTCF_18555785_Chip-Seq_ESCs_Mouse1.08776292
102NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08507907
103SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07469002
104STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06112914
105CRX_20693478_ChIP-Seq_RETINA_Mouse1.05975012
106SMRT_27268052_Chip-Seq_Bcells_Human1.05911549
107* CDX2_22108803_ChIP-Seq_LS180_Human1.05894518
108BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04144125
109ESRRB_18555785_Chip-Seq_ESCs_Mouse1.03776761
110RNF2_27304074_Chip-Seq_NSC_Mouse1.03703169
111* AR_25329375_ChIP-Seq_VCAP_Human1.03380191
112SMAD1_18555785_Chip-Seq_ESCs_Mouse1.03138859
113BCAT_22108803_ChIP-Seq_LS180_Human1.02397652
114KLF4_18555785_Chip-Seq_ESCs_Mouse1.02124810
115FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00993463
116ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00758820
117ESR1_20079471_ChIP-ChIP_T-47D_Human1.00310170
118SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99676727
119HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99418167
120GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98677212
121NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98008939
122GATA2_21666600_ChIP-Seq_HMVEC_Human0.97775239
123OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97163112
124CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96920865
125NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96417624
126VDR_24787735_ChIP-Seq_THP-1_Human0.96026805
127PRDM14_20953172_ChIP-Seq_ESCs_Human0.95976079
128MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.95251347
129TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95022727

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.86593876
2MP0002009_preneoplasia2.97815215
3MP0003303_peritoneal_inflammation2.70446883
4MP0002166_altered_tumor_susceptibility2.68965700
5MP0005409_darkened_coat_color2.64137007
6MP0002006_tumorigenesis2.56567868
7MP0001188_hyperpigmentation2.53745919
8MP0001835_abnormal_antigen_presentation2.49393958
9MP0003787_abnormal_imprinting2.35769658
10MP0005671_abnormal_response_to2.28984570
11MP0000015_abnormal_ear_pigmentation2.04761989
12MP0003724_increased_susceptibility_to2.02507107
13MP0005174_abnormal_tail_pigmentation1.98433154
14MP0008057_abnormal_DNA_replication1.93984337
15MP0001790_abnormal_immune_system1.93517215
16MP0005387_immune_system_phenotype1.93517215
17MP0006292_abnormal_olfactory_placode1.87756602
18MP0002277_abnormal_respiratory_mucosa1.80357640
19MP0003763_abnormal_thymus_physiology1.80307523
20MP0001800_abnormal_humoral_immune1.71091996
21MP0003656_abnormal_erythrocyte_physiolo1.70595658
22MP0005000_abnormal_immune_tolerance1.64350928
23MP0009785_altered_susceptibility_to1.61724481
24MP0003195_calcinosis1.59797963
25MP0003866_abnormal_defecation1.56858797
26MP0002452_abnormal_antigen_presenting1.51893773
27MP0002148_abnormal_hypersensitivity_rea1.50661521
28MP0001845_abnormal_inflammatory_respons1.50279566
29MP0002163_abnormal_gland_morphology1.49876462
30MP0003121_genomic_imprinting1.49363891
31MP0009764_decreased_sensitivity_to1.47111043
32MP0002723_abnormal_immune_serum1.47069225
33MP0005076_abnormal_cell_differentiation1.42898864
34MP0002132_abnormal_respiratory_system1.42788771
35MP0000465_gastrointestinal_hemorrhage1.41800802
36MP0001819_abnormal_immune_cell1.41198719
37MP0002420_abnormal_adaptive_immunity1.41065524
38MP0004883_abnormal_blood_vessel1.40326883
39MP0004510_myositis1.36067484
40MP0000383_abnormal_hair_follicle1.34625343
41MP0000685_abnormal_immune_system1.33358863
42MP0000703_abnormal_thymus_morphology1.32726386
43MP0003646_muscle_fatigue1.31922883
44MP0003183_abnormal_peptide_metabolism1.28941365
45MP0002398_abnormal_bone_marrow1.28720301
46MP0004808_abnormal_hematopoietic_stem1.26131711
47MP0001879_abnormal_lymphatic_vessel1.25961907
48MP0002095_abnormal_skin_pigmentation1.25085405
49MP0002332_abnormal_exercise_endurance1.23690396
50MP0004381_abnormal_hair_follicle1.23173962
51MP0003941_abnormal_skin_development1.21831371
52MP0005075_abnormal_melanosome_morpholog1.21084915
53MP0002419_abnormal_innate_immunity1.20550086
54MP0008877_abnormal_DNA_methylation1.19324402
55MP0003045_fibrosis1.17626900
56MP0001346_abnormal_lacrimal_gland1.17556318
57MP0006082_CNS_inflammation1.16033121
58MP0009278_abnormal_bone_marrow1.15801603
59MP0001533_abnormal_skeleton_physiology1.15526997
60MP0005025_abnormal_response_to1.14111589
61MP0000716_abnormal_immune_system1.13321738
62MP0005379_endocrine/exocrine_gland_phen1.12246922
63MP0004130_abnormal_muscle_cell1.11087824
64MP0000372_irregular_coat_pigmentation1.11056250
65MP0002396_abnormal_hematopoietic_system1.10353489
66MP0003252_abnormal_bile_duct1.09797608
67MP0002877_abnormal_melanocyte_morpholog1.09563436
68MP0005464_abnormal_platelet_physiology1.09526574
69MP0002405_respiratory_system_inflammati1.09104467
70MP0006072_abnormal_retinal_apoptosis1.07037758
71MP0008469_abnormal_protein_level1.05164428
72MP0005164_abnormal_response_to1.04561005
73MP0006054_spinal_hemorrhage1.02190726
74MP0005248_abnormal_Harderian_gland1.00014823
75MP0000566_synostosis0.99800474
76MP0002102_abnormal_ear_morphology0.99709692
77MP0001851_eye_inflammation0.99622613
78MP0001873_stomach_inflammation0.99591194
79MP0008058_abnormal_DNA_repair0.99462413
80MP0003136_yellow_coat_color0.98305741
81MP0002177_abnormal_outer_ear0.97901338
82MP0005645_abnormal_hypothalamus_physiol0.97780014
83MP0004947_skin_inflammation0.97297328
84MP0004484_altered_response_of0.96862123
85MP0002933_joint_inflammation0.96806400
86MP0005171_absent_coat_pigmentation0.96674217
87MP0003828_pulmonary_edema0.95469889
88MP0003890_abnormal_embryonic-extraembry0.95241094
89MP0001186_pigmentation_phenotype0.95114292
90MP0003172_abnormal_lysosome_physiology0.94861294
91MP0010094_abnormal_chromosome_stability0.93144663
92MP0003448_altered_tumor_morphology0.92935853
93MP0003436_decreased_susceptibility_to0.92104073
94MP0002928_abnormal_bile_duct0.90947302
95MP0002998_abnormal_bone_remodeling0.90776687
96MP0002938_white_spotting0.90725431
97MP0002722_abnormal_immune_system0.89760319
98MP0003950_abnormal_plasma_membrane0.88897885
99MP0010678_abnormal_skin_adnexa0.88355110
100MP0003221_abnormal_cardiomyocyte_apopto0.87420194
101MP0005310_abnormal_salivary_gland0.86838391
102MP0005397_hematopoietic_system_phenotyp0.84594315
103MP0001545_abnormal_hematopoietic_system0.84594315
104MP0002075_abnormal_coat/hair_pigmentati0.83277641
105MP0010155_abnormal_intestine_physiology0.82494225
106MP0003937_abnormal_limbs/digits/tail_de0.82104490
107MP0000689_abnormal_spleen_morphology0.80921638
108MP0000613_abnormal_salivary_gland0.78834200
109MP0010386_abnormal_urinary_bladder0.78814216
110MP0001299_abnormal_eye_distance/0.78083321
111MP0004043_abnormal_pH_regulation0.77753466
112MP0010307_abnormal_tumor_latency0.77096203
113MP0002429_abnormal_blood_cell0.76850395
114MP0002693_abnormal_pancreas_physiology0.76733861
115MP0002138_abnormal_hepatobiliary_system0.75551915
116MP0003300_gastrointestinal_ulcer0.75254333
117MP0000427_abnormal_hair_cycle0.75243816
118MP0005266_abnormal_metabolism0.74462556
119MP0003935_abnormal_craniofacial_develop0.73977537
120MP0003690_abnormal_glial_cell0.73325768
121MP0008789_abnormal_olfactory_epithelium0.73211489
122MP0000432_abnormal_head_morphology0.73120332
123MP0001501_abnormal_sleep_pattern0.73117739
124MP0008007_abnormal_cellular_replicative0.72839619
125MP0004142_abnormal_muscle_tone0.72772316
126MP0009333_abnormal_splenocyte_physiolog0.70824988
127MP0008004_abnormal_stomach_pH0.70133911
128MP0003091_abnormal_cell_migration0.70018352
129MP0005367_renal/urinary_system_phenotyp0.69974916
130MP0000516_abnormal_urinary_system0.69974916
131MP0001919_abnormal_reproductive_system0.69763795
132MP0008961_abnormal_basal_metabolism0.68148426
133MP0000249_abnormal_blood_vessel0.67232700
134MP0009763_increased_sensitivity_to0.67144823
135MP0003122_maternal_imprinting0.66888333
136MP0003755_abnormal_palate_morphology0.66882347
137MP0005253_abnormal_eye_physiology0.65665436
138MP0000627_abnormal_mammary_gland0.65398364
139MP0005376_homeostasis/metabolism_phenot0.64953795
140MP0001663_abnormal_digestive_system0.64456278
141MP0000371_diluted_coat_color0.63711020
142MP0001293_anophthalmia0.62797320

Predicted human phenotypes

RankGene SetZ-score
1Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.92440222
2Gastrointestinal infarctions (HP:0005244)3.85192786
3Abnormality of the fingertips (HP:0001211)3.81431868
4Stomatitis (HP:0010280)3.73971449
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.26241243
6Abnormality of the nasal septum (HP:0000419)3.24383434
7Volvulus (HP:0002580)3.20094582
8Recurrent bronchitis (HP:0002837)3.14337953
9Chromsome breakage (HP:0040012)3.14228739
10Papillary thyroid carcinoma (HP:0002895)3.12974282
11Abnormality of T cell number (HP:0011839)3.09487502
12Recurrent skin infections (HP:0001581)3.09084107
13T lymphocytopenia (HP:0005403)3.02842227
14Elevated erythrocyte sedimentation rate (HP:0003565)2.99173908
15Autoimmune hemolytic anemia (HP:0001890)2.96107777
16Prostate neoplasm (HP:0100787)2.95986237
17Optic neuritis (HP:0100653)2.95244954
18Retrobulbar optic neuritis (HP:0100654)2.95244954
19Spontaneous hematomas (HP:0007420)2.93597472
20Hemoptysis (HP:0002105)2.93063837
21Encephalitis (HP:0002383)2.88727533
22Thyroiditis (HP:0100646)2.85909261
23Gingival bleeding (HP:0000225)2.78869536
24Abnormality of incisor morphology (HP:0011063)2.77192100
25Lip pit (HP:0100267)2.70023042
26Genetic anticipation (HP:0003743)2.69049929
27Fair hair (HP:0002286)2.64943718
28Ectopic kidney (HP:0000086)2.61821662
29Peritonitis (HP:0002586)2.58300204
30Hematochezia (HP:0002573)2.55496950
31Chest pain (HP:0100749)2.54086611
32Recurrent viral infections (HP:0004429)2.53494393
33Stomach cancer (HP:0012126)2.52486329
34Arterial thrombosis (HP:0004420)2.50701238
35Generalized hypopigmentation of hair (HP:0011358)2.44353894
36Orchitis (HP:0100796)2.34609068
37Eosinophilia (HP:0001880)2.34495014
38Abnormal hair whorl (HP:0010721)2.34121326
39Recurrent gram-negative bacterial infections (HP:0005420)2.33657437
40Subacute progressive viral hepatitis (HP:0006572)2.27956251
41Recurrent fungal infections (HP:0002841)2.24060473
42B lymphocytopenia (HP:0010976)2.23770440
43Abnormality of B cell number (HP:0010975)2.23770440
44Deep philtrum (HP:0002002)2.22274439
45Abnormality of macrophages (HP:0004311)2.22133930
46Acute hepatic failure (HP:0006554)2.19865264
47Neoplasm of the tracheobronchial system (HP:0100552)2.19460168
48Long eyelashes (HP:0000527)2.19094093
49Abnormality of the renal cortex (HP:0011035)2.18837864
50Severe combined immunodeficiency (HP:0004430)2.18786306
51Autoimmune thrombocytopenia (HP:0001973)2.14677281
52Submucous cleft hard palate (HP:0000176)2.13771513
53Papilledema (HP:0001085)2.10552671
54Gangrene (HP:0100758)2.08901832
55Hyperventilation (HP:0002883)2.08186297
56Thyroid carcinoma (HP:0002890)2.07764924
57Alveolar cell carcinoma (HP:0006519)2.07552705
58Abnormality of T cell physiology (HP:0011840)2.07540083
59Panhypogammaglobulinemia (HP:0003139)2.06700556
60Abnormality of the incisor (HP:0000676)2.06573101
61Joint swelling (HP:0001386)2.05414760
62Recurrent abscess formation (HP:0002722)2.05211507
63Gaze-evoked nystagmus (HP:0000640)2.02839902
64Prolonged bleeding time (HP:0003010)2.02446415
65Aplasia cutis congenita (HP:0001057)2.00993313
66Chronic diarrhea (HP:0002028)1.98880035
67Inflammation of the large intestine (HP:0002037)1.98647153
68Absent frontal sinuses (HP:0002688)1.98591476
69Chronic mucocutaneous candidiasis (HP:0002728)1.98388582
70Recurrent cutaneous fungal infections (HP:0011370)1.98388582
71Pulmonary embolism (HP:0002204)1.97667339
72Myositis (HP:0100614)1.94840568
73Increased IgM level (HP:0003496)1.94815135
74Viral hepatitis (HP:0006562)1.92219462
75Colitis (HP:0002583)1.91509687
76Abnormality of the pleura (HP:0002103)1.91108326
77Granulocytopenia (HP:0001913)1.90450031
78Abnormality of eosinophils (HP:0001879)1.89920269
79Mediastinal lymphadenopathy (HP:0100721)1.89721315
80Anorexia (HP:0002039)1.89653982
81Anal stenosis (HP:0002025)1.89625191
82Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.88927984
83Short 4th metacarpal (HP:0010044)1.88927984
84Widely spaced teeth (HP:0000687)1.87753788
85Pustule (HP:0200039)1.87539778
86Vasculitis (HP:0002633)1.86074738
87Progressive cerebellar ataxia (HP:0002073)1.85910942
88Poikilocytosis (HP:0004447)1.84467851
89Abnormality of the renal collecting system (HP:0004742)1.82857891
90Eczematoid dermatitis (HP:0000976)1.81772625
91Narrow palate (HP:0000189)1.81672433
92Epistaxis (HP:0000421)1.81310532
93Protruding tongue (HP:0010808)1.80437554
94Abnormality of the endocardium (HP:0004306)1.80012677
95Duplicated collecting system (HP:0000081)1.79439079
96Microvesicular hepatic steatosis (HP:0001414)1.78839322
97Chronic hepatic failure (HP:0100626)1.78808044
98Trigonocephaly (HP:0000243)1.78701755
99Acute myeloid leukemia (HP:0004808)1.78560899
100Abnormal delayed hypersensitivity skin test (HP:0002963)1.78033984
101Cupped ear (HP:0000378)1.78009085
102Abnormality of DNA repair (HP:0003254)1.78005185
103Hypoplasia of the thymus (HP:0000778)1.77636686
104Albinism (HP:0001022)1.76748653
105Abnormality of the axillary hair (HP:0100134)1.74484437
106Abnormality of secondary sexual hair (HP:0009888)1.74484437
107Renal cortical cysts (HP:0000803)1.74425405
108Keratitis (HP:0000491)1.74079375
109Conical tooth (HP:0000698)1.73889185
110Clubbing of toes (HP:0100760)1.73011901
111Chronic otitis media (HP:0000389)1.72443529
112Bronchitis (HP:0012387)1.72374215
113Spinal cord lesions (HP:0100561)1.72349509
114Syringomyelia (HP:0003396)1.72349509
115Meningitis (HP:0001287)1.72079142
116Absent eyebrow (HP:0002223)1.72023055
117Urticaria (HP:0001025)1.69861551
118Keratoconjunctivitis sicca (HP:0001097)1.69140318
119Midline defect of the nose (HP:0004122)1.68681683
120Anhidrosis (HP:0000970)1.67113666
121IgG deficiency (HP:0004315)1.66881027
122Leukocytosis (HP:0001974)1.65502937
123Gastrointestinal inflammation (HP:0004386)1.64853910
124Truncal obesity (HP:0001956)1.63727669
125Hyperkalemia (HP:0002153)1.62959222
126Pulmonary infiltrates (HP:0002113)1.62926908
127Hypochromic microcytic anemia (HP:0004840)1.62524897
128Increased IgE level (HP:0003212)1.62215883
129Febrile seizures (HP:0002373)1.62036091
130Supernumerary ribs (HP:0005815)1.61019147
131Recurrent pneumonia (HP:0006532)1.60516473
132IgA deficiency (HP:0002720)1.57609496
133Abnormality of T cells (HP:0002843)1.57486605
134Abnormality of the parietal bone (HP:0002696)1.56716827
135Recurrent bacterial skin infections (HP:0005406)1.56023597
136Congenital stationary night blindness (HP:0007642)1.54913133
137Agammaglobulinemia (HP:0004432)1.53900559
138Lymphopenia (HP:0001888)1.53760967
139Ectropion (HP:0000656)1.53604241
140Chronic sinusitis (HP:0011109)1.53553899
141Obstructive lung disease (HP:0006536)1.53455619
142Chronic obstructive pulmonary disease (HP:0006510)1.53455619
143Urethral obstruction (HP:0000796)1.53422975
144Periodontitis (HP:0000704)1.53195512
145Abnormality of chromosome stability (HP:0003220)1.52900744
146Abnormality of the prostate (HP:0008775)1.52647240
147Gingivitis (HP:0000230)1.51455543
148Abnormality of the columella (HP:0009929)1.51137811
149Hypoproteinemia (HP:0003075)1.51001449
150Supernumerary bones of the axial skeleton (HP:0009144)1.50966419
151Abnormality of cells of the lymphoid lineage (HP:0012140)1.49597346
152Combined immunodeficiency (HP:0005387)1.48300332
153Abnormality of the frontal sinuses (HP:0002687)1.48200232
154Keratoconjunctivitis (HP:0001096)1.47922497
155Obsessive-compulsive behavior (HP:0000722)1.47239010
156Pulmonary artery stenosis (HP:0004415)1.45594658
157Thick nail (HP:0001805)1.45497279
158Increased number of teeth (HP:0011069)1.44888012

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.71658875
2MAP3K143.13558751
3CDK122.77300895
4ZAK2.50042706
5ACVR1B2.42391083
6CAMKK22.33120785
7YES12.28012807
8BRD42.27710454
9IRAK42.24305930
10RIPK42.22831581
11NUAK12.17411924
12BLK2.13514412
13IRAK32.02875857
14CASK1.95939158
15CAMK1D1.92797223
16MKNK21.87417964
17IKBKE1.85388634
18CAMK1G1.84034544
19TYK21.78503653
20INSRR1.70893090
21JAK11.70645883
22FRK1.70355852
23PIK3CG1.66663977
24EIF2AK21.62033175
25FGFR31.51879323
26NEK61.48196033
27JAK31.46418715
28BTK1.45901775
29AKT31.45622268
30LATS11.42911462
31SGK21.36099070
32TNIK1.35710313
33EPHA31.34528710
34MAP3K131.28768638
35IKBKB1.24467447
36GRK61.23909726
37BMPR1B1.22566031
38JAK21.20110022
39TEC1.19539098
40CDK31.18672010
41CHUK1.15908177
42MAP3K21.15729023
43MAP4K11.13829768
44FGFR41.12775744
45NLK1.09716603
46CDK91.09005310
47ZAP701.06303034
48FGR1.03120460
49MKNK11.02997655
50FES1.02176120
51IRAK11.01644526
52SGK30.99486098
53HCK0.95707470
54ITK0.94417388
55PDGFRB0.93657898
56SRPK10.92648130
57MARK30.90633767
58LCK0.89449489
59MAP2K30.87796118
60MATK0.87046869
61PTK2B0.86832997
62PRKCQ0.86785622
63PAK30.86719358
64ERBB30.86051010
65GRK10.85387377
66BMPR20.84135719
67ATR0.83878942
68WNK10.82989428
69STK30.82158100
70MAP3K70.81470351
71MAPK70.79053139
72STK40.78260886
73MAP3K40.77122860
74SIK30.76716895
75GRK70.76140290
76ATM0.75059891
77SYK0.72498220
78SIK20.71791731
79TRPM70.70501527
80CDK60.69890214
81PIK3CA0.67298999
82CSNK1A1L0.67052435
83PLK40.67029903
84IRAK20.65936141
85SGK10.65846664
86PKN10.65644804
87MAPK130.64577082
88STK110.63656110
89BCR0.62985150
90TBK10.62736560
91MELK0.62246775
92MARK20.61522207
93PRKAA20.61174602
94KIT0.59625211
95CLK10.58409270
96MAP4K20.58132723
97RPS6KB10.58046067
98CSF1R0.57278657
99CAMKK10.57251922
100EPHB10.56312826
101TAOK30.56208339
102FGFR20.56089792
103BRSK20.54348490
104RPS6KA50.54228622
105TNK20.53988352
106PDK10.50845177
107CSK0.50618434
108PIM10.49226461
109ADRBK10.48997285
110OBSCN0.48727784
111TLK10.47803267
112OXSR10.47249941
113PRPF4B0.46894978
114RET0.45898859
115ADRBK20.45695466
116LYN0.45551386
117DMPK0.44948745
118EIF2AK30.44777177
119MAPK140.44018064
120HIPK20.43955285
121ERBB20.43621001
122MST40.43309631
123STK390.43048846
124NEK90.42914379
125EGFR0.42860231
126ABL10.42590933
127RPS6KA40.42066891
128MAP2K60.41818545
129RPS6KB20.41380299
130SGK4940.40803341
131SGK2230.40803341
132TGFBR20.39800603
133VRK10.39703124
134DYRK1A0.39422573
135PRKCE0.36728310
136CAMK40.36575133
137RIPK10.35399599
138PBK0.35341179
139MAP3K60.35024034

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.14474307
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.11229503
3Measles_Homo sapiens_hsa051621.89964759
4Allograft rejection_Homo sapiens_hsa053301.81164622
5Intestinal immune network for IgA production_Homo sapiens_hsa046721.79262479
6Staphylococcus aureus infection_Homo sapiens_hsa051501.77205576
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.73056263
8Graft-versus-host disease_Homo sapiens_hsa053321.66271568
9T cell receptor signaling pathway_Homo sapiens_hsa046601.59980130
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.57856224
11Non-homologous end-joining_Homo sapiens_hsa034501.52533800
12Leishmaniasis_Homo sapiens_hsa051401.52035756
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.46378648
14Fanconi anemia pathway_Homo sapiens_hsa034601.46096265
15Autoimmune thyroid disease_Homo sapiens_hsa053201.43996361
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39727294
17Osteoclast differentiation_Homo sapiens_hsa043801.38531399
18Herpes simplex infection_Homo sapiens_hsa051681.36992266
19Hematopoietic cell lineage_Homo sapiens_hsa046401.33147537
20Influenza A_Homo sapiens_hsa051641.29193690
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26495968
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22181598
23B cell receptor signaling pathway_Homo sapiens_hsa046621.20379480
24Toxoplasmosis_Homo sapiens_hsa051451.20100811
25TNF signaling pathway_Homo sapiens_hsa046681.15233219
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.13914114
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11356804
28Chemokine signaling pathway_Homo sapiens_hsa040621.09593340
29Type I diabetes mellitus_Homo sapiens_hsa049401.08700766
30Phototransduction_Homo sapiens_hsa047441.07578978
31Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06732363
32Dorso-ventral axis formation_Homo sapiens_hsa043201.05910493
33Hepatitis B_Homo sapiens_hsa051611.04927728
34Prostate cancer_Homo sapiens_hsa052151.00870414
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00164879
36Malaria_Homo sapiens_hsa051440.98679198
37Rheumatoid arthritis_Homo sapiens_hsa053230.97880329
38Hepatitis C_Homo sapiens_hsa051600.97813488
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97135152
40Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94189179
41MicroRNAs in cancer_Homo sapiens_hsa052060.91949643
42ABC transporters_Homo sapiens_hsa020100.91762417
43Linoleic acid metabolism_Homo sapiens_hsa005910.90746544
44Tuberculosis_Homo sapiens_hsa051520.90283023
45Chronic myeloid leukemia_Homo sapiens_hsa052200.89614323
46Asthma_Homo sapiens_hsa053100.89137478
47Circadian rhythm_Homo sapiens_hsa047100.88924707
48Acute myeloid leukemia_Homo sapiens_hsa052210.88156050
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88094529
50Viral myocarditis_Homo sapiens_hsa054160.87885967
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85144430
52African trypanosomiasis_Homo sapiens_hsa051430.85014587
53Pancreatic cancer_Homo sapiens_hsa052120.83002649
54Type II diabetes mellitus_Homo sapiens_hsa049300.82554303
55HTLV-I infection_Homo sapiens_hsa051660.79844656
56Prolactin signaling pathway_Homo sapiens_hsa049170.79078020
57Small cell lung cancer_Homo sapiens_hsa052220.78914265
58Nicotine addiction_Homo sapiens_hsa050330.77632117
59FoxO signaling pathway_Homo sapiens_hsa040680.77423926
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76372292
61Apoptosis_Homo sapiens_hsa042100.75883615
62Adherens junction_Homo sapiens_hsa045200.74317723
63Nitrogen metabolism_Homo sapiens_hsa009100.74026161
64Antigen processing and presentation_Homo sapiens_hsa046120.73740096
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73650448
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.72575122
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72430747
68Pertussis_Homo sapiens_hsa051330.72421638
69Colorectal cancer_Homo sapiens_hsa052100.71762321
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71210814
71ErbB signaling pathway_Homo sapiens_hsa040120.70829110
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69776903
73mTOR signaling pathway_Homo sapiens_hsa041500.69057854
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68986996
75Regulation of autophagy_Homo sapiens_hsa041400.68418802
76Basal cell carcinoma_Homo sapiens_hsa052170.67017740
77Renal cell carcinoma_Homo sapiens_hsa052110.66629894
78Insulin resistance_Homo sapiens_hsa049310.66137360
79MAPK signaling pathway_Homo sapiens_hsa040100.65907607
80Systemic lupus erythematosus_Homo sapiens_hsa053220.65549825
81Pathways in cancer_Homo sapiens_hsa052000.64674734
82Axon guidance_Homo sapiens_hsa043600.64524250
83Morphine addiction_Homo sapiens_hsa050320.63935960
84Inositol phosphate metabolism_Homo sapiens_hsa005620.63224529
85Endometrial cancer_Homo sapiens_hsa052130.63024663
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61525598
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61272505
88Salmonella infection_Homo sapiens_hsa051320.61095813
89Melanoma_Homo sapiens_hsa052180.60288706
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60212642
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59748011
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.59677930
93mRNA surveillance pathway_Homo sapiens_hsa030150.59525432
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59455951
95Wnt signaling pathway_Homo sapiens_hsa043100.59409647
96TGF-beta signaling pathway_Homo sapiens_hsa043500.59215906
97Platelet activation_Homo sapiens_hsa046110.59051264
98Viral carcinogenesis_Homo sapiens_hsa052030.58903915
99Non-small cell lung cancer_Homo sapiens_hsa052230.58832277
100Fatty acid biosynthesis_Homo sapiens_hsa000610.58446402
101Renin secretion_Homo sapiens_hsa049240.58265623
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57595733
103Homologous recombination_Homo sapiens_hsa034400.57170598
104Proteoglycans in cancer_Homo sapiens_hsa052050.57114402
105Ether lipid metabolism_Homo sapiens_hsa005650.57027140
106Caffeine metabolism_Homo sapiens_hsa002320.55254108
107Choline metabolism in cancer_Homo sapiens_hsa052310.55189969
108Taste transduction_Homo sapiens_hsa047420.54868532
109p53 signaling pathway_Homo sapiens_hsa041150.54615870
110Ras signaling pathway_Homo sapiens_hsa040140.54378750
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54334215
112Legionellosis_Homo sapiens_hsa051340.54248989
113Epstein-Barr virus infection_Homo sapiens_hsa051690.53997555
114* RNA degradation_Homo sapiens_hsa030180.53946935
115Notch signaling pathway_Homo sapiens_hsa043300.53524386
116VEGF signaling pathway_Homo sapiens_hsa043700.53160360
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.52907660
118Sphingolipid metabolism_Homo sapiens_hsa006000.51843916
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51295352
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.49185996
121Phagosome_Homo sapiens_hsa041450.47152156
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45118715
123Cholinergic synapse_Homo sapiens_hsa047250.44048493
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.43710429
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.42780356
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41745665
127GnRH signaling pathway_Homo sapiens_hsa049120.41010469
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36184589
129Serotonergic synapse_Homo sapiens_hsa047260.35115596
130Renin-angiotensin system_Homo sapiens_hsa046140.34811847

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