XRCC6P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.85611287
2RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.85611287
3DNA deamination (GO:0045006)5.73168784
4positive regulation of T cell cytokine production (GO:0002726)5.66931035
5hyperosmotic salinity response (GO:0042538)5.40531569
6preassembly of GPI anchor in ER membrane (GO:0016254)5.01176365
7rRNA modification (GO:0000154)4.90066220
8positive regulation of prostaglandin secretion (GO:0032308)4.75899331
9folic acid-containing compound biosynthetic process (GO:0009396)4.68099561
10adenosine metabolic process (GO:0046085)4.54590125
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.37155286
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.37155286
13NADH dehydrogenase complex assembly (GO:0010257)4.37155286
14respiratory chain complex IV assembly (GO:0008535)4.28448723
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.28190291
16cullin deneddylation (GO:0010388)4.28034772
17protein polyglutamylation (GO:0018095)4.18139812
18DNA ligation (GO:0006266)4.13877774
19maturation of 5.8S rRNA (GO:0000460)4.13799733
20pseudouridine synthesis (GO:0001522)4.00640536
21rRNA methylation (GO:0031167)3.97213958
22cytidine deamination (GO:0009972)3.96189355
23cytidine metabolic process (GO:0046087)3.96189355
24cytidine catabolic process (GO:0006216)3.96189355
25mitochondrial RNA metabolic process (GO:0000959)3.95059573
26protein deneddylation (GO:0000338)3.89616012
27water-soluble vitamin biosynthetic process (GO:0042364)3.89303491
28regulation of prostaglandin secretion (GO:0032306)3.82261780
29GPI anchor metabolic process (GO:0006505)3.72316577
30GPI anchor biosynthetic process (GO:0006506)3.71014163
31protein complex biogenesis (GO:0070271)3.67769468
32regulation of T cell cytokine production (GO:0002724)3.65900568
33cysteine metabolic process (GO:0006534)3.65052847
34DNA catabolic process, exonucleolytic (GO:0000738)3.62193244
35purine nucleotide salvage (GO:0032261)3.58885508
36homocysteine metabolic process (GO:0050667)3.52650205
37protein-cofactor linkage (GO:0018065)3.49401853
38sulfur amino acid catabolic process (GO:0000098)3.46752482
39mitochondrial respiratory chain complex assembly (GO:0033108)3.41048900
40regulation of cilium movement (GO:0003352)3.39411621
41tRNA modification (GO:0006400)3.38340399
42pteridine-containing compound biosynthetic process (GO:0042559)3.35804566
43establishment of integrated proviral latency (GO:0075713)3.35747170
44cytochrome complex assembly (GO:0017004)3.35591948
45regulation of immunoglobulin secretion (GO:0051023)3.28589353
46IMP biosynthetic process (GO:0006188)3.26256157
47proteasome assembly (GO:0043248)3.25787208
48tRNA processing (GO:0008033)3.24748294
49tetrahydrofolate metabolic process (GO:0046653)3.24139576
50platelet dense granule organization (GO:0060155)3.22650067
51pyrimidine ribonucleoside catabolic process (GO:0046133)3.22307836
52positive regulation of heat generation (GO:0031652)3.19136762
53artery smooth muscle contraction (GO:0014824)3.10417175
54mannosylation (GO:0097502)3.05674491
55CENP-A containing nucleosome assembly (GO:0034080)3.04128475
56L-serine metabolic process (GO:0006563)3.00879685
57replication fork processing (GO:0031297)2.94526959
58detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.93996695
59chromatin remodeling at centromere (GO:0031055)2.93541436
60primary amino compound metabolic process (GO:1901160)2.92451175
61establishment of viral latency (GO:0019043)2.91529607
62C-terminal protein lipidation (GO:0006501)2.90620737
63transcription elongation from RNA polymerase III promoter (GO:0006385)2.89490735
64termination of RNA polymerase III transcription (GO:0006386)2.89490735
65branched-chain amino acid catabolic process (GO:0009083)2.89254921
66DNA double-strand break processing (GO:0000729)2.87919204
67tRNA metabolic process (GO:0006399)2.83600299
68positive regulation of icosanoid secretion (GO:0032305)2.82431203
69microtubule nucleation (GO:0007020)2.82330877
70positive regulation of fatty acid transport (GO:2000193)2.81228900
71regulation of fever generation (GO:0031620)2.75719837
72signal peptide processing (GO:0006465)2.75496358
73positive regulation of T cell chemotaxis (GO:0010820)2.74116782
74regulation of T cell chemotaxis (GO:0010819)2.74116782
75short-chain fatty acid metabolic process (GO:0046459)2.74053319
76IMP metabolic process (GO:0046040)2.73031891
77branched-chain amino acid metabolic process (GO:0009081)2.71361945
78fucose catabolic process (GO:0019317)2.71164997
79L-fucose metabolic process (GO:0042354)2.71164997
80L-fucose catabolic process (GO:0042355)2.71164997
81response to lipoprotein particle (GO:0055094)2.69652554
82C-terminal protein amino acid modification (GO:0018410)2.69064992
83response to pheromone (GO:0019236)2.68970541
84valine metabolic process (GO:0006573)2.68908620
85regulation of microtubule-based movement (GO:0060632)2.68870197
86RNA modification (GO:0009451)2.68642744
87establishment of protein localization to mitochondrial membrane (GO:0090151)2.67687107
88regulation of heat generation (GO:0031650)2.67508352
89somatic hypermutation of immunoglobulin genes (GO:0016446)2.67155154
90somatic diversification of immune receptors via somatic mutation (GO:0002566)2.67155154
91regulation of hexokinase activity (GO:1903299)2.65324466
92regulation of glucokinase activity (GO:0033131)2.65324466
93sulfation (GO:0051923)2.65151842
94folic acid-containing compound metabolic process (GO:0006760)2.63365495
95tonic smooth muscle contraction (GO:0014820)2.62397595
96ribosome assembly (GO:0042255)2.62276819
97positive regulation of response to tumor cell (GO:0002836)2.59786430
98positive regulation of immune response to tumor cell (GO:0002839)2.59786430
99regulation of immune response to tumor cell (GO:0002837)2.59786430
100regulation of response to tumor cell (GO:0002834)2.59786430

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.99466128
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.13432411
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.11773975
4ZNF274_21170338_ChIP-Seq_K562_Hela3.50888643
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.96709588
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.93401420
7VDR_22108803_ChIP-Seq_LS180_Human2.84811538
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.82373875
9E2F7_22180533_ChIP-Seq_HELA_Human2.59754193
10NOTCH1_21737748_ChIP-Seq_TLL_Human2.45874812
11VDR_23849224_ChIP-Seq_CD4+_Human2.31359065
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.25947874
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.23188969
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.18177917
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14341597
16FOXP3_21729870_ChIP-Seq_TREG_Human2.07187580
17ELK1_19687146_ChIP-ChIP_HELA_Human2.06208994
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05634638
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03050932
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.02635709
21EWS_26573619_Chip-Seq_HEK293_Human1.94062238
22MYC_18940864_ChIP-ChIP_HL60_Human1.87890089
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.85473105
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83043338
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.71370628
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69959119
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63671619
28TP53_22573176_ChIP-Seq_HFKS_Human1.57173388
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53483963
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52808687
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52627716
32IGF1R_20145208_ChIP-Seq_DFB_Human1.52498545
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51709671
34CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.49750157
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47789993
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46546039
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44580564
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43753599
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43738582
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43535394
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41483077
42CBP_20019798_ChIP-Seq_JUKART_Human1.41483077
43GBX2_23144817_ChIP-Seq_PC3_Human1.38688337
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.36728621
45P300_19829295_ChIP-Seq_ESCs_Human1.36430549
46GABP_19822575_ChIP-Seq_HepG2_Human1.36395515
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34134807
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33317593
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.32966119
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32966119
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30961177
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29151285
53AR_20517297_ChIP-Seq_VCAP_Human1.28477421
54CDX2_22108803_ChIP-Seq_LS180_Human1.27382124
55CIITA_25753668_ChIP-Seq_RAJI_Human1.27055262
56AUTS2_25519132_ChIP-Seq_293T-REX_Human1.25096017
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24713382
58NCOR_22424771_ChIP-Seq_293T_Human1.23612879
59HOXB7_26014856_ChIP-Seq_BT474_Human1.23229657
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22990271
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.20503135
62PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.19925379
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18046886
64FUS_26573619_Chip-Seq_HEK293_Human1.16576125
65FOXH1_21741376_ChIP-Seq_EPCs_Human1.15451301
66CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.13233113
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11958977
68FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11511423
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10354248
70NANOG_19829295_ChIP-Seq_ESCs_Human1.08502728
71SOX2_19829295_ChIP-Seq_ESCs_Human1.08502728
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08337625
73ER_23166858_ChIP-Seq_MCF-7_Human1.08110789
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07574034
75HTT_18923047_ChIP-ChIP_STHdh_Human1.06474497
76BCAT_22108803_ChIP-Seq_LS180_Human1.05343352
77ERG_20517297_ChIP-Seq_VCAP_Human1.04227080
78MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04223442
79IRF1_19129219_ChIP-ChIP_H3396_Human1.04096985
80ELK1_22589737_ChIP-Seq_MCF10A_Human1.02795798
81HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02321667
82E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99237744
83NFE2_27457419_Chip-Seq_LIVER_Mouse0.99229593
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97617319
85TCF4_22108803_ChIP-Seq_LS180_Human0.97116171
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96475996
87EZH2_27294783_Chip-Seq_NPCs_Mouse0.96236086
88MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95910200
89FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.95420728
90DCP1A_22483619_ChIP-Seq_HELA_Human0.94493914
91IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92795172
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92437584
93MYC_19829295_ChIP-Seq_ESCs_Human0.91370494
94TAF2_19829295_ChIP-Seq_ESCs_Human0.91190036
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90909512
96GATA3_21878914_ChIP-Seq_MCF-7_Human0.90723017
97HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.90459420
98NANOG_20526341_ChIP-Seq_ESCs_Human0.89909550
99SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88282603
100GATA3_26560356_Chip-Seq_TH2_Human0.86434212

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.03702655
2MP0004885_abnormal_endolymph2.89295275
3MP0005360_urolithiasis2.77757963
4MP0002736_abnormal_nociception_after2.70593996
5MP0002138_abnormal_hepatobiliary_system2.65933210
6MP0002102_abnormal_ear_morphology2.47407676
7MP0004147_increased_porphyrin_level2.47088072
8MP0000013_abnormal_adipose_tissue2.45996872
9MP0002876_abnormal_thyroid_physiology2.44148810
10MP0001986_abnormal_taste_sensitivity2.18608510
11MP0001968_abnormal_touch/_nociception2.10963017
12MP0005646_abnormal_pituitary_gland2.10098945
13MP0008058_abnormal_DNA_repair2.04868812
14MP0008995_early_reproductive_senescence2.02686813
15MP0001661_extended_life_span2.01640788
16MP0002139_abnormal_hepatobiliary_system2.00358446
17MP0008877_abnormal_DNA_methylation1.99959935
18MP0003195_calcinosis1.99240340
19MP0008872_abnormal_physiological_respon1.99011300
20MP0008789_abnormal_olfactory_epithelium1.93501817
21MP0003183_abnormal_peptide_metabolism1.93199079
22MP0005084_abnormal_gallbladder_morpholo1.89516532
23MP0003724_increased_susceptibility_to1.77071213
24MP0005551_abnormal_eye_electrophysiolog1.74565137
25MP0001529_abnormal_vocalization1.67793121
26MP0005253_abnormal_eye_physiology1.65278968
27MP0005332_abnormal_amino_acid1.64787801
28MP0001764_abnormal_homeostasis1.64183222
29MP0005671_abnormal_response_to1.63702769
30MP0003786_premature_aging1.62187984
31MP0000427_abnormal_hair_cycle1.61851809
32MP0003011_delayed_dark_adaptation1.60101871
33MP0002163_abnormal_gland_morphology1.59990377
34MP0006276_abnormal_autonomic_nervous1.58058855
35MP0000372_irregular_coat_pigmentation1.52814617
36MP0001984_abnormal_olfaction1.49543795
37MP0009780_abnormal_chondrocyte_physiolo1.47008143
38MP0006072_abnormal_retinal_apoptosis1.45292090
39MP0003718_maternal_effect1.44981255
40MP0003693_abnormal_embryo_hatching1.41513885
41MP0002837_dystrophic_cardiac_calcinosis1.39939982
42MP0008007_abnormal_cellular_replicative1.39577815
43MP0003186_abnormal_redox_activity1.38220269
44MP0009697_abnormal_copulation1.37624377
45MP0010094_abnormal_chromosome_stability1.36187074
46MP0004782_abnormal_surfactant_physiolog1.35685091
47MP0000685_abnormal_immune_system1.30203848
48MP0005085_abnormal_gallbladder_physiolo1.28648659
49MP0008875_abnormal_xenobiotic_pharmacok1.25253369
50MP0005379_endocrine/exocrine_gland_phen1.24498696
51MP0005410_abnormal_fertilization1.23987801
52MP0005171_absent_coat_pigmentation1.15254765
53MP0006054_spinal_hemorrhage1.15118358
54MP0003252_abnormal_bile_duct1.14913266
55MP0006035_abnormal_mitochondrial_morpho1.14851372
56MP0005499_abnormal_olfactory_system1.12292634
57MP0005394_taste/olfaction_phenotype1.12292634
58MP0002938_white_spotting1.11527769
59MP0002148_abnormal_hypersensitivity_rea1.07408240
60MP0005636_abnormal_mineral_homeostasis1.07212154
61MP0003787_abnormal_imprinting1.06963201
62MP0000538_abnormal_urinary_bladder1.06660125
63MP0010386_abnormal_urinary_bladder1.02791616
64MP0002095_abnormal_skin_pigmentation1.02707244
65MP0008775_abnormal_heart_ventricle1.01384490
66MP0004145_abnormal_muscle_electrophysio1.00596246
67MP0002234_abnormal_pharynx_morphology0.98368605
68MP0000647_abnormal_sebaceous_gland0.97304784
69MP0002160_abnormal_reproductive_system0.95977098
70MP0000383_abnormal_hair_follicle0.95476547
71MP0002928_abnormal_bile_duct0.95272266
72MP0004142_abnormal_muscle_tone0.93748591
73MP0001486_abnormal_startle_reflex0.91000005
74MP0001756_abnormal_urination0.90237572
75MP0005167_abnormal_blood-brain_barrier0.89238687
76MP0004019_abnormal_vitamin_homeostasis0.89091817
77MP0005220_abnormal_exocrine_pancreas0.87774735
78MP0005389_reproductive_system_phenotype0.87467697
79MP0004043_abnormal_pH_regulation0.86975511
80MP0006036_abnormal_mitochondrial_physio0.86406446
81MP0009333_abnormal_splenocyte_physiolog0.86349882
82MP0005670_abnormal_white_adipose0.84668588
83MP0005083_abnormal_biliary_tract0.82516915
84MP0000230_abnormal_systemic_arterial0.81744622
85MP0009765_abnormal_xenobiotic_induced0.80992162
86MP0004957_abnormal_blastocyst_morpholog0.79758776
87MP0002723_abnormal_immune_serum0.79663606
88MP0000613_abnormal_salivary_gland0.75624725
89MP0000631_abnormal_neuroendocrine_gland0.75253147
90MP0001835_abnormal_antigen_presentation0.75125510
91MP0002735_abnormal_chemical_nociception0.74527517
92MP0001929_abnormal_gametogenesis0.74479434
93MP0000639_abnormal_adrenal_gland0.74329624
94MP0009643_abnormal_urine_homeostasis0.73176513
95MP0001963_abnormal_hearing_physiology0.71636731
96MP0002006_tumorigenesis0.70929133
97MP0001800_abnormal_humoral_immune0.70855438
98MP0002653_abnormal_ependyma_morphology0.68926551
99MP0001765_abnormal_ion_homeostasis0.66982728
100MP0001485_abnormal_pinna_reflex0.66799041

Predicted human phenotypes

RankGene SetZ-score
1Hyperalaninemia (HP:0003348)5.78156810
2Abnormality of pyruvate family amino acid metabolism (HP:0010915)5.78156810
3Abnormality of alanine metabolism (HP:0010916)5.78156810
4Methylmalonic acidemia (HP:0002912)4.02538282
5Attenuation of retinal blood vessels (HP:0007843)3.46431757
6Decreased electroretinogram (ERG) amplitude (HP:0000654)3.41158413
7Methylmalonic aciduria (HP:0012120)3.37966694
8Abnormality of glycine metabolism (HP:0010895)3.20619379
9Abnormality of serine family amino acid metabolism (HP:0010894)3.20619379
10Abnormality of serum amino acid levels (HP:0003112)3.16079406
11Congenital sensorineural hearing impairment (HP:0008527)3.07045307
12Hyperglycinuria (HP:0003108)3.01961613
13Hyperglycinemia (HP:0002154)3.00393024
14Increased serum lactate (HP:0002151)2.97249067
15Constricted visual fields (HP:0001133)2.93411546
16Pancreatic cysts (HP:0001737)2.90444969
17Abolished electroretinogram (ERG) (HP:0000550)2.85548045
18Abnormality of the labia minora (HP:0012880)2.68794037
19Pendular nystagmus (HP:0012043)2.66939939
20Elevated erythrocyte sedimentation rate (HP:0003565)2.60940611
21Pancytopenia (HP:0001876)2.57779895
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.56726718
23Abnormality of the renal cortex (HP:0011035)2.55684256
24Pancreatic fibrosis (HP:0100732)2.43922140
25Acute necrotizing encephalopathy (HP:0006965)2.42598239
26Mitochondrial inheritance (HP:0001427)2.40892202
27Increased CSF lactate (HP:0002490)2.38151510
28Acute encephalopathy (HP:0006846)2.37013931
29Duplicated collecting system (HP:0000081)2.35520395
30True hermaphroditism (HP:0010459)2.34508824
31Abnormality of the vitamin B12 metabolism (HP:0004341)2.31835612
32Nephronophthisis (HP:0000090)2.30136018
33Spontaneous hematomas (HP:0007420)2.29858292
343-Methylglutaconic aciduria (HP:0003535)2.29785954
35Abnormality of the renal collecting system (HP:0004742)2.26403447
36Abnormality of the renal medulla (HP:0100957)2.25202409
37Abnormal delayed hypersensitivity skin test (HP:0002963)2.19854725
38Abnormality of vitamin B metabolism (HP:0004340)2.19071675
39Progressive macrocephaly (HP:0004481)2.18826300
40Renal cortical cysts (HP:0000803)2.18072737
41Lactic acidosis (HP:0003128)2.16354388
42Optic disc pallor (HP:0000543)2.16275213
43Type I transferrin isoform profile (HP:0003642)2.15339466
44Abnormality of DNA repair (HP:0003254)2.10416127
45Birth length less than 3rd percentile (HP:0003561)2.10012029
46Hepatocellular necrosis (HP:0001404)2.05784078
47Abnormal mitochondria in muscle tissue (HP:0008316)2.05684559
48Congenital stationary night blindness (HP:0007642)2.05443896
49Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.05212995
50Increased corneal curvature (HP:0100692)1.97847910
51Keratoconus (HP:0000563)1.97847910
52Medial flaring of the eyebrow (HP:0010747)1.96448872
53Chronic hepatic failure (HP:0100626)1.96162752
54Thyroiditis (HP:0100646)1.95182171
55Abnormal protein glycosylation (HP:0012346)1.95000274
56Abnormal glycosylation (HP:0012345)1.95000274
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95000274
58Abnormal protein N-linked glycosylation (HP:0012347)1.95000274
59Neutropenia (HP:0001875)1.93587911
60Meckel diverticulum (HP:0002245)1.93571200
61Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.93325571
62Hypoplasia of the uterus (HP:0000013)1.92661258
63Cerebral edema (HP:0002181)1.92581730
64Pigmentary retinal degeneration (HP:0001146)1.92521902
65Increased hepatocellular lipid droplets (HP:0006565)1.92407602
66Abnormal biliary tract physiology (HP:0012439)1.92112864
67Bile duct proliferation (HP:0001408)1.92112864
68IgG deficiency (HP:0004315)1.91564081
69Aplasia/Hypoplasia of the uvula (HP:0010293)1.90783395
70Abnormality of the ileum (HP:0001549)1.89632480
71Lipid accumulation in hepatocytes (HP:0006561)1.89364114
72Type 2 muscle fiber atrophy (HP:0003554)1.89011773
73Lethargy (HP:0001254)1.87669691
74Abnormality of the carotid arteries (HP:0005344)1.87503002
75Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87008409
76Dicarboxylic aciduria (HP:0003215)1.87008409
77Metabolic acidosis (HP:0001942)1.86711638
78Aplasia/Hypoplasia of the spleen (HP:0010451)1.84008682
79Severe combined immunodeficiency (HP:0004430)1.83043709
80Hepatic necrosis (HP:0002605)1.82320935
81Delayed CNS myelination (HP:0002188)1.82317323
82Hydroxyprolinuria (HP:0003080)1.80500180
83Abnormality of proline metabolism (HP:0010907)1.80500180
84Ectopic kidney (HP:0000086)1.79754203
85Poor speech (HP:0002465)1.79478798
86Aplasia/hypoplasia of the uterus (HP:0008684)1.79311657
87Supernumerary spleens (HP:0009799)1.78896145
88Generalized aminoaciduria (HP:0002909)1.77415764
89Aplasia/Hypoplasia of the fovea (HP:0008060)1.77029925
90Hypoplasia of the fovea (HP:0007750)1.77029925
91Hypomagnesemia (HP:0002917)1.76783791
92Colon cancer (HP:0003003)1.76219327
93Abnormality of sulfur amino acid metabolism (HP:0004339)1.76148184
94Hypoplastic left heart (HP:0004383)1.75146071
95Abnormality of midbrain morphology (HP:0002418)1.72269387
96Molar tooth sign on MRI (HP:0002419)1.72269387
97Ketoacidosis (HP:0001993)1.72213982
98Renal Fanconi syndrome (HP:0001994)1.72105450
99Reduced subcutaneous adipose tissue (HP:0003758)1.71647560
100Clubbing of toes (HP:0100760)1.70939541

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.78161795
2TLK13.21789881
3FRK2.93246139
4MAP4K22.68522976
5EIF2AK32.45520943
6ZAK2.37079364
7ADRBK22.30403577
8BUB12.16856961
9NUAK12.13226811
10TSSK62.09391493
11VRK11.92703457
12MST41.91441217
13BCR1.90174584
14BMPR1B1.85293736
15BCKDK1.84781390
16TESK21.80613712
17NEK11.62816801
18PLK31.58736416
19TRIM281.57510895
20GRK11.53865157
21TXK1.49992843
22CDK91.45949508
23MAP4K11.42326952
24WNK31.41003244
25PDK21.37645993
26MAP3K131.37622129
27BRSK21.35349451
28TAF11.27012973
29CSNK1G31.24597025
30FES1.24360903
31DYRK21.23543525
32MAP2K31.15747042
33EIF2AK21.13916530
34CSNK1G21.12817123
35ATR1.12248721
36DAPK21.07529823
37ADRBK11.06369747
38CSNK1A1L1.05349741
39MAP3K121.04260639
40OXSR11.03599819
41LMTK21.03515734
42KDR1.02821324
43FGR1.01521983
44PLK41.00671542
45TGFBR11.00227202
46CDK81.00097377
47SRPK10.99478167
48MAP3K30.97604506
49PLK20.97020119
50IKBKB0.96117635
51ACVR1B0.95257761
52CSNK1G10.94126418
53TGFBR20.93439777
54GRK70.92866116
55STK160.91117478
56PIK3CG0.90130155
57RPS6KB20.88761223
58CAMKK20.88291129
59GRK50.87854916
60PINK10.80914879
61PASK0.80012268
62MAPKAPK50.78530930
63CDK190.73018564
64PRKCE0.70471251
65RPS6KA40.68683813
66INSRR0.67908359
67CSF1R0.67023054
68NEK90.65411688
69TIE10.64346868
70PRKCQ0.64140688
71JAK30.63309914
72MKNK20.62279009
73TTK0.57760083
74CCNB10.57609609
75FGFR20.57105250
76PLK10.55701825
77RPS6KA50.55634771
78PBK0.53409521
79SYK0.51853005
80CSNK1A10.47091527
81NTRK20.45839499
82PRKCI0.44649428
83PHKG20.43621902
84PHKG10.43621902
85MAP3K140.43154727
86BRSK10.42719499
87LIMK10.41660327
88MAPK130.41492463
89AURKB0.40679296
90WNK40.40204746
91DAPK10.39945898
92ERBB40.38965480
93MAP2K60.38313068
94GRK60.37898398
95STK100.37429555
96PRKCA0.37092797
97AURKA0.36763909
98PRKCG0.36743879
99TBK10.34840120
100EPHA30.34467268

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006703.14808372
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.00970571
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.76276697
4Non-homologous end-joining_Homo sapiens_hsa034502.70435337
5Proteasome_Homo sapiens_hsa030502.39811344
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.27005520
7Protein export_Homo sapiens_hsa030602.24186558
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.18030386
9RNA polymerase_Homo sapiens_hsa030202.15998106
10Oxidative phosphorylation_Homo sapiens_hsa001902.01691990
11Propanoate metabolism_Homo sapiens_hsa006401.99953382
12Sulfur metabolism_Homo sapiens_hsa009201.94862770
13Cysteine and methionine metabolism_Homo sapiens_hsa002701.78112708
14Fanconi anemia pathway_Homo sapiens_hsa034601.76789659
15Selenocompound metabolism_Homo sapiens_hsa004501.72674821
16Graft-versus-host disease_Homo sapiens_hsa053321.71578561
17Fatty acid elongation_Homo sapiens_hsa000621.67349014
18Antigen processing and presentation_Homo sapiens_hsa046121.53790436
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53403357
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52959734
21RNA degradation_Homo sapiens_hsa030181.50676671
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.49455842
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.47093718
24Basal transcription factors_Homo sapiens_hsa030221.43451866
25Asthma_Homo sapiens_hsa053101.42872042
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38039043
27Collecting duct acid secretion_Homo sapiens_hsa049661.37057032
28Parkinsons disease_Homo sapiens_hsa050121.36952517
29Mismatch repair_Homo sapiens_hsa034301.36790846
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.35719495
31Type I diabetes mellitus_Homo sapiens_hsa049401.32653936
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30500103
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30242297
34Tryptophan metabolism_Homo sapiens_hsa003801.29206499
35Allograft rejection_Homo sapiens_hsa053301.28074243
36Nitrogen metabolism_Homo sapiens_hsa009101.26450881
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25719390
38Phototransduction_Homo sapiens_hsa047441.25652984
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.24275211
40Homologous recombination_Homo sapiens_hsa034401.23349727
41Autoimmune thyroid disease_Homo sapiens_hsa053201.22748318
42Peroxisome_Homo sapiens_hsa041461.16520389
43Primary immunodeficiency_Homo sapiens_hsa053401.12888751
44Nucleotide excision repair_Homo sapiens_hsa034201.11052877
45Retinol metabolism_Homo sapiens_hsa008301.07526136
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06784311
47Regulation of autophagy_Homo sapiens_hsa041401.05564506
48Purine metabolism_Homo sapiens_hsa002301.03621328
49RNA transport_Homo sapiens_hsa030131.02749246
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01945469
51Biosynthesis of amino acids_Homo sapiens_hsa012301.01580318
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00455013
53Rheumatoid arthritis_Homo sapiens_hsa053231.00196912
54Linoleic acid metabolism_Homo sapiens_hsa005910.99913959
55Pyrimidine metabolism_Homo sapiens_hsa002400.90548613
56Butanoate metabolism_Homo sapiens_hsa006500.89752635
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89435586
58Caffeine metabolism_Homo sapiens_hsa002320.86582249
59DNA replication_Homo sapiens_hsa030300.85355803
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83173550
61Base excision repair_Homo sapiens_hsa034100.82936167
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82846855
63Spliceosome_Homo sapiens_hsa030400.79596420
64Chemical carcinogenesis_Homo sapiens_hsa052040.79571359
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79234265
66Olfactory transduction_Homo sapiens_hsa047400.79225115
67Steroid biosynthesis_Homo sapiens_hsa001000.77380319
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77195736
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77064677
70Glutathione metabolism_Homo sapiens_hsa004800.74085516
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73282697
72Nicotine addiction_Homo sapiens_hsa050330.72260004
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71559634
74Metabolic pathways_Homo sapiens_hsa011000.71557954
75Sulfur relay system_Homo sapiens_hsa041220.71522286
76Huntingtons disease_Homo sapiens_hsa050160.70501987
77Ether lipid metabolism_Homo sapiens_hsa005650.70038644
78Arachidonic acid metabolism_Homo sapiens_hsa005900.69674374
79Alzheimers disease_Homo sapiens_hsa050100.68986586
80Fat digestion and absorption_Homo sapiens_hsa049750.68149652
81Arginine biosynthesis_Homo sapiens_hsa002200.65650431
82Morphine addiction_Homo sapiens_hsa050320.64808746
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.63514910
84beta-Alanine metabolism_Homo sapiens_hsa004100.63112194
85Carbon metabolism_Homo sapiens_hsa012000.61936061
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59740708
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58733222
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58110335
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56723288
90Tyrosine metabolism_Homo sapiens_hsa003500.56275905
91Systemic lupus erythematosus_Homo sapiens_hsa053220.55929157
92GABAergic synapse_Homo sapiens_hsa047270.54252092
93Arginine and proline metabolism_Homo sapiens_hsa003300.52523664
94Phenylalanine metabolism_Homo sapiens_hsa003600.49635508
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49597278
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48545811
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44099777
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43444563
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42512163
100Fatty acid metabolism_Homo sapiens_hsa012120.42038483

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