XPO5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.98937335
2nuclear pore organization (GO:0006999)5.97637208
3DNA unwinding involved in DNA replication (GO:0006268)5.60412688
4protein localization to kinetochore (GO:0034501)4.89750127
5folic acid-containing compound biosynthetic process (GO:0009396)4.79473738
6mitotic nuclear envelope disassembly (GO:0007077)4.77550634
7pre-miRNA processing (GO:0031054)4.67826989
8nuclear envelope disassembly (GO:0051081)4.53227509
9membrane disassembly (GO:0030397)4.53227509
10pore complex assembly (GO:0046931)4.42423057
11regulation of translational fidelity (GO:0006450)4.41428629
12DNA replication-dependent nucleosome assembly (GO:0006335)4.36095468
13DNA replication-dependent nucleosome organization (GO:0034723)4.36095468
14IMP biosynthetic process (GO:0006188)4.30538255
15DNA duplex unwinding (GO:0032508)4.11099340
16DNA geometric change (GO:0032392)4.08915317
17heterochromatin organization (GO:0070828)4.03208780
18mitotic sister chromatid cohesion (GO:0007064)4.02907426
19protein localization to chromosome, centromeric region (GO:0071459)3.99088699
20sister chromatid segregation (GO:0000819)3.90272974
21establishment of integrated proviral latency (GO:0075713)3.88649025
22mitotic chromosome condensation (GO:0007076)3.87699098
23regulation of translational termination (GO:0006449)3.86985724
24nucleobase biosynthetic process (GO:0046112)3.86293426
25DNA topological change (GO:0006265)3.85270880
26regulation of gene silencing by RNA (GO:0060966)3.84092207
27regulation of posttranscriptional gene silencing (GO:0060147)3.84092207
28regulation of gene silencing by miRNA (GO:0060964)3.84092207
29regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.76808156
30DNA replication initiation (GO:0006270)3.76368929
31negative regulation of histone methylation (GO:0031061)3.73805920
32IMP metabolic process (GO:0046040)3.69741762
33mitotic sister chromatid segregation (GO:0000070)3.69474836
34regulation of histone H3-K9 methylation (GO:0051570)3.69025689
35spliceosomal tri-snRNP complex assembly (GO:0000244)3.67228378
36regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.63780713
37DNA strand elongation involved in DNA replication (GO:0006271)3.63544762
38nuclear envelope organization (GO:0006998)3.58856592
39telomere maintenance via recombination (GO:0000722)3.57000900
40regulation of spindle organization (GO:0090224)3.55945787
41chromatin assembly (GO:0031497)3.54299492
42mitotic metaphase plate congression (GO:0007080)3.53676984
43mitotic recombination (GO:0006312)3.53266610
44regulation of RNA export from nucleus (GO:0046831)3.52305553
45protein complex localization (GO:0031503)3.51417387
46DNA synthesis involved in DNA repair (GO:0000731)3.50149549
47dosage compensation (GO:0007549)3.48257832
48regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.47122717
49positive regulation of chromosome segregation (GO:0051984)3.46192650
50paraxial mesoderm development (GO:0048339)3.44866713
51DNA strand elongation (GO:0022616)3.44727098
52non-recombinational repair (GO:0000726)3.44379013
53double-strand break repair via nonhomologous end joining (GO:0006303)3.44379013
54formation of translation preinitiation complex (GO:0001731)3.43598626
55negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.42149381
56regulation of sister chromatid cohesion (GO:0007063)3.41047653
57L-serine metabolic process (GO:0006563)3.39837305
58regulation of mitotic spindle organization (GO:0060236)3.37470216
59peptidyl-arginine omega-N-methylation (GO:0035247)3.37204909
60translesion synthesis (GO:0019985)3.36657900
61regulation of centriole replication (GO:0046599)3.32544561
62tRNA aminoacylation for protein translation (GO:0006418)3.29823331
63ribosome assembly (GO:0042255)3.24695437
64positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.22737034
65positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.22737034
66positive regulation of mitotic sister chromatid separation (GO:1901970)3.22737034
67amino acid activation (GO:0043038)3.21540280
68tRNA aminoacylation (GO:0043039)3.21540280
69DNA conformation change (GO:0071103)3.20843180
70histone H2A monoubiquitination (GO:0035518)3.20817558
71cellular protein complex localization (GO:0034629)3.19973768
72metaphase plate congression (GO:0051310)3.19949649
73regulation of centrosome cycle (GO:0046605)3.19878024
74proline biosynthetic process (GO:0006561)3.18221952
75peptidyl-lysine dimethylation (GO:0018027)3.15301215
76meiotic chromosome segregation (GO:0045132)3.15292229
77purine nucleobase biosynthetic process (GO:0009113)3.14892888
78chromatin assembly or disassembly (GO:0006333)3.14567199
79DNA packaging (GO:0006323)3.12545540
80positive regulation of cell cycle checkpoint (GO:1901978)3.08033693
81regulation of chromosome segregation (GO:0051983)3.08002693
82NLS-bearing protein import into nucleus (GO:0006607)3.06652006
83ribonucleoprotein complex biogenesis (GO:0022613)3.04893208
84mRNA transport (GO:0051028)3.04845624
85postreplication repair (GO:0006301)3.04029070
86nucleosome disassembly (GO:0006337)3.03465190
87protein-DNA complex disassembly (GO:0032986)3.03465190
88regulation of nucleobase-containing compound transport (GO:0032239)3.03352442
89mRNA stabilization (GO:0048255)3.03159018
90RNA stabilization (GO:0043489)3.03159018
91viral mRNA export from host cell nucleus (GO:0046784)3.01993156
92chromosome segregation (GO:0007059)3.01762909
93negative regulation of RNA splicing (GO:0033119)3.01579125
94peptidyl-arginine methylation (GO:0018216)2.99900233
95peptidyl-arginine N-methylation (GO:0035246)2.99900233
96protein localization to chromosome (GO:0034502)2.99366487
97maturation of SSU-rRNA (GO:0030490)2.99125119
98spindle checkpoint (GO:0031577)2.97714043
99mitotic spindle checkpoint (GO:0071174)2.96805335
100telomere maintenance via telomere lengthening (GO:0010833)2.95914706
101glucocorticoid receptor signaling pathway (GO:0042921)2.95678965
102regulation of translational elongation (GO:0006448)2.95436157
103rRNA transcription (GO:0009303)2.94820898
104nucleotide-excision repair, DNA gap filling (GO:0006297)2.94113916
105negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.93816416
106negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.93816416
107regulation of DNA damage checkpoint (GO:2000001)2.92588977
108DNA replication checkpoint (GO:0000076)2.91754957
109DNA strand renaturation (GO:0000733)2.91291645
110mitotic spindle assembly checkpoint (GO:0007094)2.89470471
111chaperone-mediated protein complex assembly (GO:0051131)2.89135167
112spindle assembly involved in mitosis (GO:0090307)2.89057640
113chromosome condensation (GO:0030261)2.88463710
114positive regulation of SMAD protein import into nucleus (GO:0060391)2.88224210
115ATP-dependent chromatin remodeling (GO:0043044)2.87788379
116kinetochore organization (GO:0051383)2.87452651
117negative regulation of DNA repair (GO:0045738)2.86443326
118negative regulation of chromosome segregation (GO:0051985)2.86394466
119negative regulation of mRNA processing (GO:0050686)2.86323155
120establishment of chromosome localization (GO:0051303)2.86221348
121regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.85907298
122somatic diversification of immune receptors via somatic mutation (GO:0002566)2.84964976
123somatic hypermutation of immunoglobulin genes (GO:0016446)2.84964976
124regulation of mitotic metaphase/anaphase transition (GO:0030071)2.82723131
125telomere maintenance via semi-conservative replication (GO:0032201)2.82535081
126histone arginine methylation (GO:0034969)2.81822319
127negative regulation of mRNA metabolic process (GO:1903312)2.81180019
128nucleic acid transport (GO:0050657)2.80797606
129RNA transport (GO:0050658)2.80797606
130establishment of RNA localization (GO:0051236)2.80797606
131spindle assembly checkpoint (GO:0071173)2.80565670
132microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.80288793
133mitotic G1 DNA damage checkpoint (GO:0031571)2.79851185
134regulation of centrosome duplication (GO:0010824)2.79788445
135ribosome biogenesis (GO:0042254)2.78363360
136negative regulation of mitotic sister chromatid separation (GO:2000816)2.77964411
137negative regulation of mitotic sister chromatid segregation (GO:0033048)2.77964411
138negative regulation of sister chromatid segregation (GO:0033046)2.77964411

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.14461333
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.86541771
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.67191373
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.53837102
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.21392402
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.93889583
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.84411335
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.74698849
9MYC_22102868_ChIP-Seq_BL_Human2.57732750
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.52076486
11AR_21909140_ChIP-Seq_LNCAP_Human2.51326572
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42394255
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.30694286
14* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.28377312
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26311611
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20702551
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.03067717
18E2F7_22180533_ChIP-Seq_HELA_Human10.0485545
19* XRN2_22483619_ChIP-Seq_HELA_Human1.95507167
20SALL1_21062744_ChIP-ChIP_HESCs_Human1.89941000
21* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89732006
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.86429005
23SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.85956369
24* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80955520
25CIITA_25753668_ChIP-Seq_RAJI_Human1.76880020
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.71632810
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70715016
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.66085696
29ESR1_15608294_ChIP-ChIP_MCF-7_Human1.62852730
30CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.59711183
31* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59541252
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56793325
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.56101046
34KDM5A_27292631_Chip-Seq_BREAST_Human1.54905805
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.54642261
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52670200
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.50616836
38* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44558654
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42556146
40CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39553432
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39387772
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39087472
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38838462
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37647522
45TTF2_22483619_ChIP-Seq_HELA_Human1.37234826
46* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34914934
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34181109
48FOXP3_21729870_ChIP-Seq_TREG_Human1.33292149
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31579398
50CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.31541649
51SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31521119
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31259309
53* GABP_19822575_ChIP-Seq_HepG2_Human1.30486715
54TFEB_21752829_ChIP-Seq_HELA_Human1.30085009
55VDR_23849224_ChIP-Seq_CD4+_Human1.30047561
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.29032236
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24744096
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.22763196
59NANOG_21062744_ChIP-ChIP_HESCs_Human1.21810146
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.21500417
61ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.21019133
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20472312
63DCP1A_22483619_ChIP-Seq_HELA_Human1.18634862
64CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17522547
65TCF3_18692474_ChIP-Seq_MEFs_Mouse1.17518029
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.16512858
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16473240
68VDR_21846776_ChIP-Seq_THP-1_Human1.16113618
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16053542
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12763609
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12140596
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11665254
73DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11494887
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10675058
75* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10509758
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09327192
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08617574
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.08315370
79ELK1_19687146_ChIP-ChIP_HELA_Human1.07458741
80NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06893602
81CHD1_26751641_Chip-Seq_LNCaP_Human1.06447268
82KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.04168655
83* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.04115739
84GABP_17652178_ChIP-ChIP_JURKAT_Human1.03491931
85SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.02930771
86TCF3_18692474_ChIP-Seq_MESCs_Mouse1.00138900
87HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99745633
88CLOCK_20551151_ChIP-Seq_293T_Human0.99052629
89ZNF263_19887448_ChIP-Seq_K562_Human0.98885518
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98660894
91PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97500210
92KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96757498
93KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96757498
94KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96757498
95TCF7_22412390_ChIP-Seq_EML_Mouse0.95604379
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95300088
97ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95177893
98SOX17_20123909_ChIP-Seq_XEN_Mouse0.94375104
99NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.93749183
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92044496
101KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90651409
102ATF3_27146783_Chip-Seq_COLON_Human0.89817427
103KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89426310
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88909169
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88714863
106ZFP281_27345836_Chip-Seq_ESCs_Mouse0.88524288
107* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.88109008
108NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.87586494
109TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87034464
110PKCTHETA_26484144_Chip-Seq_BREAST_Human0.86766312
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86626434
112* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86351939
113SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85370014
114SRF_21415370_ChIP-Seq_HL-1_Mouse0.85329264
115SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85302612
116NCOR1_26117541_ChIP-Seq_K562_Human0.85253987
117* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84618589
118KDM2B_26808549_Chip-Seq_DND41_Human0.84073392
119PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.82599303
120MYC_18940864_ChIP-ChIP_HL60_Human0.82369434
121HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.81510372
122TBX5_21415370_ChIP-Seq_HL-1_Mouse0.80065950
123NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.76712499

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.83329905
2MP0003111_abnormal_nucleus_morphology3.63570901
3MP0010352_gastrointestinal_tract_polyps3.62526300
4MP0003693_abnormal_embryo_hatching3.44957520
5MP0004957_abnormal_blastocyst_morpholog3.42014664
6MP0003077_abnormal_cell_cycle3.21050760
7MP0003705_abnormal_hypodermis_morpholog3.10080359
8MP0008057_abnormal_DNA_replication3.01482554
9MP0003123_paternal_imprinting2.70552203
10MP0005076_abnormal_cell_differentiation2.64925429
11MP0010307_abnormal_tumor_latency2.63623755
12MP0001730_embryonic_growth_arrest2.61675832
13MP0000350_abnormal_cell_proliferation2.35007633
14MP0008007_abnormal_cellular_replicative2.30314625
15MP0008058_abnormal_DNA_repair2.11317471
16MP0004197_abnormal_fetal_growth/weight/2.08725624
17MP0005380_embryogenesis_phenotype2.06430157
18MP0001672_abnormal_embryogenesis/_devel2.06430157
19MP0002084_abnormal_developmental_patter2.06230154
20MP0000537_abnormal_urethra_morphology1.99892993
21MP0001697_abnormal_embryo_size1.97119963
22MP0010030_abnormal_orbit_morphology1.94994217
23MP0008932_abnormal_embryonic_tissue1.94520231
24MP0003984_embryonic_growth_retardation1.93503268
25MP0002085_abnormal_embryonic_tissue1.91054156
26MP0002088_abnormal_embryonic_growth/wei1.90492358
27MP0003890_abnormal_embryonic-extraembry1.83067909
28MP0002086_abnormal_extraembryonic_tissu1.79472861
29MP0002080_prenatal_lethality1.74679234
30MP0009697_abnormal_copulation1.71323203
31MP0003121_genomic_imprinting1.70161663
32MP0002396_abnormal_hematopoietic_system1.68268595
33MP0008877_abnormal_DNA_methylation1.62150432
34MP0003566_abnormal_cell_adhesion1.59988974
35MP0009053_abnormal_anal_canal1.59874940
36MP0003941_abnormal_skin_development1.59069293
37MP0001293_anophthalmia1.55338392
38MP0004233_abnormal_muscle_weight1.54915615
39MP0010234_abnormal_vibrissa_follicle1.54601187
40MP0002009_preneoplasia1.52816919
41MP0003718_maternal_effect1.49457277
42MP0001661_extended_life_span1.46532071
43MP0005623_abnormal_meninges_morphology1.45130966
44MP0008438_abnormal_cutaneous_collagen1.43767692
45MP0004808_abnormal_hematopoietic_stem1.43074145
46MP0000569_abnormal_digit_pigmentation1.42213308
47MP0002653_abnormal_ependyma_morphology1.39420055
48MP0001849_ear_inflammation1.38838508
49MP0000733_abnormal_muscle_development1.35110638
50MP0006054_spinal_hemorrhage1.33752914
51MP0000428_abnormal_craniofacial_morphol1.31739968
52MP0005023_abnormal_wound_healing1.31375713
53MP0003119_abnormal_digestive_system1.27815304
54MP0003283_abnormal_digestive_organ1.27475491
55MP0009672_abnormal_birth_weight1.26048399
56MP0009703_decreased_birth_body1.22442647
57MP0003315_abnormal_perineum_morphology1.20997660
58MP0003567_abnormal_fetal_cardiomyocyte1.18648316
59MP0000313_abnormal_cell_death1.15364943
60MP0001915_intracranial_hemorrhage1.13346642
61MP0002092_abnormal_eye_morphology1.11883603
62MP0002111_abnormal_tail_morphology1.09164165
63MP0002877_abnormal_melanocyte_morpholog1.08679656
64MP0003115_abnormal_respiratory_system1.08383344
65MP0002697_abnormal_eye_size1.07126842
66MP0000566_synostosis1.06706529
67MP0001346_abnormal_lacrimal_gland1.06669549
68MP0002019_abnormal_tumor_incidence1.05836453
69MP0003937_abnormal_limbs/digits/tail_de1.03384085
70MP0005501_abnormal_skin_physiology1.03047545
71MP0003786_premature_aging1.01903346
72MP0003943_abnormal_hepatobiliary_system0.99781963
73MP0006035_abnormal_mitochondrial_morpho0.99312546
74MP0000490_abnormal_crypts_of0.98724947
75MP0003935_abnormal_craniofacial_develop0.97129786
76MP0006292_abnormal_olfactory_placode0.96144826
77MP0002925_abnormal_cardiovascular_devel0.94845087
78MP0009278_abnormal_bone_marrow0.92745062
79MP0002796_impaired_skin_barrier0.88259166
80MP0005621_abnormal_cell_physiology0.88008899
81MP0005384_cellular_phenotype0.87824834
82MP0000432_abnormal_head_morphology0.87713510
83MP0004264_abnormal_extraembryonic_tissu0.87628444
84MP0005187_abnormal_penis_morphology0.87146270
85MP0003861_abnormal_nervous_system0.86816300
86MP0000358_abnormal_cell_content/0.85645821
87MP0003221_abnormal_cardiomyocyte_apopto0.83772592
88MP0008770_decreased_survivor_rate0.83325533
89MP0000678_abnormal_parathyroid_gland0.83190245
90MP0000703_abnormal_thymus_morphology0.82105085
91MP0002210_abnormal_sex_determination0.80761889
92MP0000534_abnormal_ureter_morphology0.80427316
93MP0002089_abnormal_postnatal_growth/wei0.80211688
94MP0002938_white_spotting0.79965182
95MP0004133_heterotaxia0.79234866
96MP0003300_gastrointestinal_ulcer0.79149244
97MP0001145_abnormal_male_reproductive0.78818029
98MP0003091_abnormal_cell_migration0.78137678
99MP0003942_abnormal_urinary_system0.76956121
100MP0000371_diluted_coat_color0.76559434
101MP0000579_abnormal_nail_morphology0.73230100
102MP0005275_abnormal_skin_tensile0.73107805
103MP0000266_abnormal_heart_morphology0.72952820
104MP0002932_abnormal_joint_morphology0.72907578
105MP0002269_muscular_atrophy0.72747287
106MP0002160_abnormal_reproductive_system0.72495615
107MP0003950_abnormal_plasma_membrane0.70245888
108MP0005503_abnormal_tendon_morphology0.69815999
109MP0001929_abnormal_gametogenesis0.69720143
110MP0003699_abnormal_female_reproductive0.68880813
111MP0000377_abnormal_hair_follicle0.68755153
112MP0002233_abnormal_nose_morphology0.67617783
113MP0001286_abnormal_eye_development0.67566407
114MP0005451_abnormal_body_composition0.66792682
115MP0003385_abnormal_body_wall0.66397924
116MP0000647_abnormal_sebaceous_gland0.66306808
117MP0000653_abnormal_sex_gland0.65275812
118MP0002098_abnormal_vibrissa_morphology0.65144768
119MP0002114_abnormal_axial_skeleton0.65081728
120MP0001299_abnormal_eye_distance/0.64725688
121MP0002081_perinatal_lethality0.63881325
122MP0003755_abnormal_palate_morphology0.63876987
123MP0001216_abnormal_epidermal_layer0.62578979
124MP0000627_abnormal_mammary_gland0.62251041
125MP0004185_abnormal_adipocyte_glucose0.62084320
126MP0005397_hematopoietic_system_phenotyp0.61620352
127MP0001545_abnormal_hematopoietic_system0.61620352
128MP0010630_abnormal_cardiac_muscle0.61129661
129MP0001340_abnormal_eyelid_morphology0.60848947
130MP0010678_abnormal_skin_adnexa0.60662165
131MP0003279_aneurysm0.60595677

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.28546198
2Abnormality of the astrocytes (HP:0100707)3.55213149
3Astrocytoma (HP:0009592)3.55213149
4Short 4th metacarpal (HP:0010044)3.35979089
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.35979089
6Medulloblastoma (HP:0002885)3.22779220
7Selective tooth agenesis (HP:0001592)3.18456990
8Abnormality of the preputium (HP:0100587)2.92738675
9Colon cancer (HP:0003003)2.91088551
10Glioma (HP:0009733)2.89202882
11Increased nuchal translucency (HP:0010880)2.86014315
12Nephroblastoma (Wilms tumor) (HP:0002667)2.76896068
13Reticulocytopenia (HP:0001896)2.73982334
14Microvesicular hepatic steatosis (HP:0001414)2.70254890
15Meckel diverticulum (HP:0002245)2.68939364
16Multiple enchondromatosis (HP:0005701)2.68344341
17Deviation of the thumb (HP:0009603)2.65437198
18High anterior hairline (HP:0009890)2.60733227
19Renal duplication (HP:0000075)2.57194363
20Hyperacusis (HP:0010780)2.56439514
21Proximal placement of thumb (HP:0009623)2.56249014
22Abnormality of the ileum (HP:0001549)2.55328664
23Abnormality of the 4th metacarpal (HP:0010012)2.54761509
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.53294025
25Abnormality of cochlea (HP:0000375)2.53155601
26Embryonal renal neoplasm (HP:0011794)2.52402627
27Rhabdomyosarcoma (HP:0002859)2.49435681
28Neoplasm of the oral cavity (HP:0100649)2.45889431
29Volvulus (HP:0002580)2.45740309
30Progressive muscle weakness (HP:0003323)2.45736694
31Abnormality of the anterior horn cell (HP:0006802)2.42295194
32Degeneration of anterior horn cells (HP:0002398)2.42295194
33Neoplasm of striated muscle (HP:0009728)2.42128530
34Protrusio acetabuli (HP:0003179)2.41264189
35Missing ribs (HP:0000921)2.41054058
36Abnormality of the calcaneus (HP:0008364)2.39833164
37Myelodysplasia (HP:0002863)2.38195865
38Ankle contracture (HP:0006466)2.37310844
39Shallow orbits (HP:0000586)2.36705507
40Overlapping toe (HP:0001845)2.36679340
41Duplicated collecting system (HP:0000081)2.34381747
42Bowel diverticulosis (HP:0005222)2.31916182
43Abnormality of the labia minora (HP:0012880)2.31023866
44Septate vagina (HP:0001153)2.29326033
45Abnormality of the lower motor neuron (HP:0002366)2.28060711
46Abnormality of glycolysis (HP:0004366)2.27490010
47Abnormal lung lobation (HP:0002101)2.24970288
48Cerebral aneurysm (HP:0004944)2.22525524
49Urethral obstruction (HP:0000796)2.21164160
50Asymmetry of the thorax (HP:0001555)2.20464747
51Squamous cell carcinoma (HP:0002860)2.20223087
52Duodenal stenosis (HP:0100867)2.19204468
53Small intestinal stenosis (HP:0012848)2.19204468
54Pelvic girdle muscle weakness (HP:0003749)2.17980905
55Absent radius (HP:0003974)2.17423511
56Heterotopia (HP:0002282)2.17310237
57Biliary tract neoplasm (HP:0100574)2.16824810
58Basal cell carcinoma (HP:0002671)2.16684188
59Insomnia (HP:0100785)2.13927360
60High pitched voice (HP:0001620)2.12554097
61Renovascular hypertension (HP:0100817)2.11589763
62Increased density of long bones (HP:0006392)2.11255348
63Cholecystitis (HP:0001082)2.11066309
64Abnormal gallbladder physiology (HP:0012438)2.11066309
65Progressive external ophthalmoplegia (HP:0000590)2.10941725
66Gastrointestinal carcinoma (HP:0002672)2.10772061
67Malignant gastrointestinal tract tumors (HP:0006749)2.10772061
68Chromsome breakage (HP:0040012)2.08482368
69Hypopigmentation of the fundus (HP:0007894)2.07791271
70Cutaneous melanoma (HP:0012056)2.07525653
71Broad thumb (HP:0011304)2.02971449
72Ankyloglossia (HP:0010296)2.00902305
73Abnormality of the pons (HP:0007361)1.99877503
74Pseudobulbar signs (HP:0002200)1.99505348
75Spinal muscular atrophy (HP:0007269)1.99104839
76Hand muscle atrophy (HP:0009130)1.98407329
77Horseshoe kidney (HP:0000085)1.98109156
78Absent forearm bone (HP:0003953)1.97694978
79Aplasia involving forearm bones (HP:0009822)1.97694978
80Abnormality of oral frenula (HP:0000190)1.97177577
81Cafe-au-lait spot (HP:0000957)1.96883901
82Prominent nose (HP:0000448)1.96527271
83Agnosia (HP:0010524)1.95395947
84Sandal gap (HP:0001852)1.94715718
85Facial cleft (HP:0002006)1.93923327
86Short humerus (HP:0005792)1.93378674
87Long eyelashes (HP:0000527)1.93216914
88Duplication of thumb phalanx (HP:0009942)1.92583748
89Pointed chin (HP:0000307)1.91595704
90Impulsivity (HP:0100710)1.91526923
91Skin tags (HP:0010609)1.91305091
92Genu recurvatum (HP:0002816)1.90947402
93Dysmetric saccades (HP:0000641)1.90877000
94Choanal atresia (HP:0000453)1.90773568
95Abnormality of chromosome stability (HP:0003220)1.89158377
96Abnormal number of incisors (HP:0011064)1.88937363
97Homocystinuria (HP:0002156)1.88892967
98Abnormality of homocysteine metabolism (HP:0010919)1.88892967
99Morphological abnormality of the inner ear (HP:0011390)1.87426055
100Aplasia/hypoplasia of the humerus (HP:0006507)1.86339894
101Abnormality of the renal collecting system (HP:0004742)1.86225770
102Atresia of the external auditory canal (HP:0000413)1.85900467
103Abnormality of reticulocytes (HP:0004312)1.85436067
104Abnormality of the duodenum (HP:0002246)1.85294481
105Shoulder girdle muscle weakness (HP:0003547)1.85217167
106Birth length less than 3rd percentile (HP:0003561)1.85141989
107Elfin facies (HP:0004428)1.84904888
108Premature ovarian failure (HP:0008209)1.84831264
109Acute myeloid leukemia (HP:0004808)1.84415350
110Fibrous tissue neoplasm (HP:0012316)1.83881074
111Broad palm (HP:0001169)1.83254393
112Skull defect (HP:0001362)1.82288127
113Ulnar bowing (HP:0003031)1.81479009
114Fibroma (HP:0010614)1.81241483
115Embryonal neoplasm (HP:0002898)1.80934619
116Chromosomal breakage induced by crosslinking agents (HP:0003221)1.80703953
117Trigonocephaly (HP:0000243)1.80392703
118Neoplasm of the pancreas (HP:0002894)1.79958425
119Trismus (HP:0000211)1.79309047
120Aplasia/Hypoplasia of the sternum (HP:0006714)1.79135701
121Broad phalanges of the hand (HP:0009768)1.77396629
122Capillary hemangiomas (HP:0005306)1.76948981
123Increased serum pyruvate (HP:0003542)1.76927569
124Ectopic kidney (HP:0000086)1.76400604
125Breast hypoplasia (HP:0003187)1.76372240
12611 pairs of ribs (HP:0000878)1.76055160
127Adenoma sebaceum (HP:0009720)1.75716597
128Angiofibromas (HP:0010615)1.75716597
129Spastic diplegia (HP:0001264)1.75584610
130Distal upper limb amyotrophy (HP:0007149)1.75274868
131Upper limb amyotrophy (HP:0009129)1.75274868
132Facial hemangioma (HP:0000329)1.74740361
133Abnormality of DNA repair (HP:0003254)1.74735887
134Subacute progressive viral hepatitis (HP:0006572)1.74222536
135Abnormality of the musculature of the pelvis (HP:0001469)1.73830923
136Abnormality of the hip-girdle musculature (HP:0001445)1.73830923
137Dilatation of the ascending aorta (HP:0005111)1.73314385
138Bladder diverticulum (HP:0000015)1.72000506
139Patellar aplasia (HP:0006443)1.71743909
140Poikiloderma (HP:0001029)1.71134166
141Preauricular skin tag (HP:0000384)1.71115671
142Ovarian neoplasm (HP:0100615)1.71023869
143Short thumb (HP:0009778)1.70701957
144Intestinal polyp (HP:0005266)1.70484708
145Obsessive-compulsive behavior (HP:0000722)1.70422104
146Freckling (HP:0001480)1.69986890
147Amaurosis fugax (HP:0100576)1.69786980
148Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.69769730
149Atrophy/Degeneration involving motor neurons (HP:0007373)1.69666339
150Deep philtrum (HP:0002002)1.69359929
151Arteriovenous malformation (HP:0100026)1.69211573
152Hypoplasia of the pons (HP:0012110)1.69081511
153Abnormality of the carotid arteries (HP:0005344)1.68772436
154Sloping forehead (HP:0000340)1.67897973
155Aplasia/Hypoplasia of the patella (HP:0006498)1.67806287
156Overriding aorta (HP:0002623)1.66367641
157Cutis marmorata (HP:0000965)1.66339635
158Ureteral duplication (HP:0000073)1.66172494
159Cortical dysplasia (HP:0002539)1.65581203
160Uterine leiomyosarcoma (HP:0002891)1.63777317
161Leiomyosarcoma (HP:0100243)1.63777317
162Termporal pattern (HP:0011008)1.61572779
163Insidious onset (HP:0003587)1.61572779
164Abnormality of cells of the erythroid lineage (HP:0012130)1.61330407
165Acute lymphatic leukemia (HP:0006721)1.59901512
166Secondary amenorrhea (HP:0000869)1.59137963

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.21622595
2CDK123.59552786
3EEF2K3.40394134
4NEK12.85685893
5PKN22.84449543
6NEK22.67042917
7SMG12.62037639
8WEE12.53275578
9TSSK62.35986949
10SCYL22.27627971
11TRIB32.21188623
12PASK2.17806262
13BUB12.07691569
14PBK2.07619246
15MAP3K101.98333346
16TTK1.96131771
17TTN1.83549780
18RPS6KB21.80732925
19TAF11.75424043
20ALK1.64953944
21ATR1.60837204
22NME21.58349421
23LATS11.49984111
24EPHA21.49213255
25MAP3K81.48301962
26CHEK11.43682455
27STK101.43355122
28PLK11.42102237
29SRPK11.40513938
30BRD41.38732997
31MTOR1.38458672
32PDGFRA1.38382807
33CDK41.37680305
34PLK31.35205079
35EIF2AK31.35005312
36VRK21.34057280
37TGFBR11.33981640
38CDK71.33782961
39EIF2AK11.30904108
40AURKB1.30743982
41IRAK31.22335113
42PAK41.22044508
43LATS21.20913334
44CDK61.20688543
45RPS6KA41.17152666
46CHEK21.15027129
47TESK21.13995780
48FGFR11.12742449
49PTK61.12672024
50PAK21.11537170
51ICK1.10977945
52BRSK21.09783593
53FLT31.07635638
54LRRK21.02505075
55CDK21.00410801
56ATM0.99033411
57ACVR1B0.97246882
58STK30.95860410
59TESK10.94641835
60MKNK10.94468512
61PNCK0.92972707
62RIPK10.89061234
63BMX0.87416088
64PDK30.85843330
65PDK40.85843330
66BRSK10.83181601
67MELK0.81668625
68CLK10.81482514
69BRAF0.80263176
70FGFR40.76465544
71DDR20.75566932
72STK40.75108292
73AURKA0.74826807
74VRK10.74668868
75CDK10.74124730
76TLK10.73019777
77EIF2AK20.72310078
78CDK80.70685236
79KSR10.68660114
80MAP3K90.66572679
81DYRK30.65058296
82MST1R0.64773793
83PRKD30.62559482
84CCNB10.62389742
85PIM10.60326972
86PRKDC0.59887165
87ERBB40.59599477
88CSNK1E0.59364622
89CAMK1D0.59076098
90CSNK1D0.58668806
91AKT20.58235130
92NME10.57328459
93PAK10.53638041
94TYRO30.52536852
95MAP3K130.51186034
96MAP2K30.48333978
97CSNK2A20.47308085
98RPS6KB10.45147640
99PDGFRB0.45021433
100MAPK140.44973765
101CDK11A0.44757461
102STK160.44562355
103MET0.44069989
104PTK20.42644088
105CDK150.42290097
106PLK40.41052888
107CDK180.40963492
108MAPK110.40494320
109ILK0.37876785
110ZAK0.37003800
111KSR20.36956777
112MAPKAPK50.36203722
113SIK10.35775964
114NTRK10.35687023
115GSK3B0.35136213
116CAMK1G0.33594442
117CDK140.33399866
118CSNK2A10.33286754
119MAPK10.33119132
120CDK30.32173297
121CDK90.31769778
122AKT10.31700602
123RET0.30978964
124RAF10.30484959
125RPS6KA10.30448015
126CSNK1A1L0.29107544
127PRKCI0.27787840
128MKNK20.27674937
129FGFR20.27661228
130FGFR30.26278892

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.85352468
2Mismatch repair_Homo sapiens_hsa034303.33504823
3* RNA transport_Homo sapiens_hsa030133.25418400
4One carbon pool by folate_Homo sapiens_hsa006703.19791308
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.13537687
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.06376681
7Spliceosome_Homo sapiens_hsa030402.79740499
8Cell cycle_Homo sapiens_hsa041102.75690252
9mRNA surveillance pathway_Homo sapiens_hsa030152.31850768
10Base excision repair_Homo sapiens_hsa034102.28365402
11Nucleotide excision repair_Homo sapiens_hsa034202.07235500
12Systemic lupus erythematosus_Homo sapiens_hsa053221.82168896
13Non-homologous end-joining_Homo sapiens_hsa034501.72556206
14Homologous recombination_Homo sapiens_hsa034401.65246399
15Viral carcinogenesis_Homo sapiens_hsa052031.59205237
16p53 signaling pathway_Homo sapiens_hsa041151.52687820
17Fanconi anemia pathway_Homo sapiens_hsa034601.50793196
18Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.50692324
19RNA degradation_Homo sapiens_hsa030181.45941472
20MicroRNAs in cancer_Homo sapiens_hsa052061.44749073
21mTOR signaling pathway_Homo sapiens_hsa041501.42999098
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.41150126
23Oocyte meiosis_Homo sapiens_hsa041141.34150048
24Biosynthesis of amino acids_Homo sapiens_hsa012301.32191663
25Selenocompound metabolism_Homo sapiens_hsa004501.31606976
26Chronic myeloid leukemia_Homo sapiens_hsa052201.30365203
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.28022745
28Hippo signaling pathway_Homo sapiens_hsa043901.24708830
29Small cell lung cancer_Homo sapiens_hsa052221.21331617
30Vitamin B6 metabolism_Homo sapiens_hsa007501.21161421
31Adherens junction_Homo sapiens_hsa045201.19551944
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17185571
33Basal cell carcinoma_Homo sapiens_hsa052171.16853871
34HTLV-I infection_Homo sapiens_hsa051661.16788358
35Colorectal cancer_Homo sapiens_hsa052101.13428196
36Thyroid cancer_Homo sapiens_hsa052161.12846358
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08486446
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06528130
39Antigen processing and presentation_Homo sapiens_hsa046121.05870177
40Steroid biosynthesis_Homo sapiens_hsa001001.05107331
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05091197
42Pyruvate metabolism_Homo sapiens_hsa006201.04176430
43RNA polymerase_Homo sapiens_hsa030201.02097873
44Pyrimidine metabolism_Homo sapiens_hsa002401.01312688
45Proteoglycans in cancer_Homo sapiens_hsa052050.98875504
46Epstein-Barr virus infection_Homo sapiens_hsa051690.97896484
47Lysine degradation_Homo sapiens_hsa003100.97388062
48Bladder cancer_Homo sapiens_hsa052190.95994403
49Alcoholism_Homo sapiens_hsa050340.95447980
50Sulfur relay system_Homo sapiens_hsa041220.92721893
51Endometrial cancer_Homo sapiens_hsa052130.90619849
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90386252
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87842177
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86029602
55Non-small cell lung cancer_Homo sapiens_hsa052230.85629038
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85163820
57TGF-beta signaling pathway_Homo sapiens_hsa043500.85113505
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81936240
59Basal transcription factors_Homo sapiens_hsa030220.80721179
60Hedgehog signaling pathway_Homo sapiens_hsa043400.77520783
61Notch signaling pathway_Homo sapiens_hsa043300.75697582
62Focal adhesion_Homo sapiens_hsa045100.72875529
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72165751
64Viral myocarditis_Homo sapiens_hsa054160.70811426
65Herpes simplex infection_Homo sapiens_hsa051680.70409414
66Pancreatic cancer_Homo sapiens_hsa052120.69386180
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.69197157
68HIF-1 signaling pathway_Homo sapiens_hsa040660.68926933
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68139025
70Glioma_Homo sapiens_hsa052140.66411726
71Prostate cancer_Homo sapiens_hsa052150.66117033
72Carbon metabolism_Homo sapiens_hsa012000.65134515
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.63331894
74N-Glycan biosynthesis_Homo sapiens_hsa005100.62538716
75Pathways in cancer_Homo sapiens_hsa052000.60302308
76Pentose phosphate pathway_Homo sapiens_hsa000300.59918170
77Proteasome_Homo sapiens_hsa030500.59753088
78Tight junction_Homo sapiens_hsa045300.58660572
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57827130
80Hepatitis B_Homo sapiens_hsa051610.55759956
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55719745
82Ribosome_Homo sapiens_hsa030100.55076443
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.54531504
84Legionellosis_Homo sapiens_hsa051340.53098584
85Wnt signaling pathway_Homo sapiens_hsa043100.52770839
86Apoptosis_Homo sapiens_hsa042100.52596215
87Acute myeloid leukemia_Homo sapiens_hsa052210.51932487
88AMPK signaling pathway_Homo sapiens_hsa041520.51779929
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50092443
90ErbB signaling pathway_Homo sapiens_hsa040120.48866868
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48748751
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47263843
93Insulin signaling pathway_Homo sapiens_hsa049100.45778964
94Fatty acid metabolism_Homo sapiens_hsa012120.44901913
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44747647
96Glucagon signaling pathway_Homo sapiens_hsa049220.44212096
97Arginine biosynthesis_Homo sapiens_hsa002200.43724099
98Melanoma_Homo sapiens_hsa052180.43556116
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43380987
100Renal cell carcinoma_Homo sapiens_hsa052110.42673658
101ECM-receptor interaction_Homo sapiens_hsa045120.42412251
102Estrogen signaling pathway_Homo sapiens_hsa049150.41863337
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40263721
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40040403
105Purine metabolism_Homo sapiens_hsa002300.39851272
106Shigellosis_Homo sapiens_hsa051310.39083593
107VEGF signaling pathway_Homo sapiens_hsa043700.38891721
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38528850
109Folate biosynthesis_Homo sapiens_hsa007900.38487696
110Galactose metabolism_Homo sapiens_hsa000520.37576613
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.37504620
112FoxO signaling pathway_Homo sapiens_hsa040680.37489559
113Insulin resistance_Homo sapiens_hsa049310.37431650
114Fructose and mannose metabolism_Homo sapiens_hsa000510.34342161
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33637231
116Propanoate metabolism_Homo sapiens_hsa006400.30095935
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29776457
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27712693
119Fatty acid elongation_Homo sapiens_hsa000620.26577008
120Inositol phosphate metabolism_Homo sapiens_hsa005620.26420048
121Fatty acid biosynthesis_Homo sapiens_hsa000610.24444271

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