XPNPEP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the cytosolic form of a metalloaminopeptidase that catalyzes the cleavage of the N-terminal amino acid adjacent to a proline residue. The gene product may play a role in degradation and maturation of tachykinins, neuropeptides, and peptide hormones. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)6.29321893
2COPI coating of Golgi vesicle (GO:0048205)5.71850891
3Golgi transport vesicle coating (GO:0048200)5.71850891
4protein neddylation (GO:0045116)5.40306011
5glycolipid catabolic process (GO:0019377)4.61190406
6beta-amyloid metabolic process (GO:0050435)4.53720567
7nucleobase biosynthetic process (GO:0046112)4.31768087
8regulation of integrin activation (GO:0033623)4.23927688
9purine nucleobase biosynthetic process (GO:0009113)4.20984136
10regulation of integrin-mediated signaling pathway (GO:2001044)4.19724533
11glycosphingolipid catabolic process (GO:0046479)4.14670520
12protein localization to kinetochore (GO:0034501)4.09381529
13endothelium development (GO:0003158)4.06083938
14mitotic nuclear envelope disassembly (GO:0007077)3.98586206
15nuclear pore organization (GO:0006999)3.92920565
16platelet aggregation (GO:0070527)3.90433483
17formation of translation preinitiation complex (GO:0001731)3.89617175
18DNA replication initiation (GO:0006270)3.87463656
19IMP biosynthetic process (GO:0006188)3.87094086
20positive regulation of Rho protein signal transduction (GO:0035025)3.74690376
21folic acid-containing compound biosynthetic process (GO:0009396)3.74588041
22nuclear pore complex assembly (GO:0051292)3.72540400
23mitotic metaphase plate congression (GO:0007080)3.72512247
24DNA replication-dependent nucleosome assembly (GO:0006335)3.68068168
25DNA replication-dependent nucleosome organization (GO:0034723)3.68068168
26extracellular fibril organization (GO:0043206)3.67383400
27nuclear envelope disassembly (GO:0051081)3.61696572
28membrane disassembly (GO:0030397)3.61696572
29regulation of posttranscriptional gene silencing (GO:0060147)3.56760212
30regulation of gene silencing by miRNA (GO:0060964)3.56760212
31regulation of gene silencing by RNA (GO:0060966)3.56760212
32ceramide catabolic process (GO:0046514)3.53721464
33DNA strand elongation involved in DNA replication (GO:0006271)3.52191149
34vesicle coating (GO:0006901)3.49453818
35DNA unwinding involved in DNA replication (GO:0006268)3.49427030
36epithelial cell-cell adhesion (GO:0090136)3.49039113
37protein localization to chromosome, centromeric region (GO:0071459)3.45819710
38paraxial mesoderm development (GO:0048339)3.45095760
39DNA replication checkpoint (GO:0000076)3.42242529
40positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.40614863
41cyclooxygenase pathway (GO:0019371)3.39653627
42negative regulation of protein localization to cell surface (GO:2000009)3.39098809
43DNA strand elongation (GO:0022616)3.37808329
44proline biosynthetic process (GO:0006561)3.37770666
45maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.37655613
46fibril organization (GO:0097435)3.36109656
47neutrophil activation involved in immune response (GO:0002283)3.35615038
48regulation of penile erection (GO:0060405)3.35457950
49mitotic sister chromatid segregation (GO:0000070)3.33984461
50positive regulation of macrophage differentiation (GO:0045651)3.33647006
51retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.32542980
52ribosome assembly (GO:0042255)3.29050432
53regulation of spindle organization (GO:0090224)3.27483527
54regulation of translational fidelity (GO:0006450)3.22696276
55angiogenesis involved in wound healing (GO:0060055)3.22019680
56somatic hypermutation of immunoglobulin genes (GO:0016446)3.12106446
57somatic diversification of immune receptors via somatic mutation (GO:0002566)3.12106446
58folic acid metabolic process (GO:0046655)3.11179925
59COPII vesicle coating (GO:0048208)3.10956282
60pore complex assembly (GO:0046931)3.10869715
61metaphase plate congression (GO:0051310)3.09329737
62stress fiber assembly (GO:0043149)3.09169136
63fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.08913844
64positive regulation of endothelial cell differentiation (GO:0045603)3.08541622
65angiotensin maturation (GO:0002003)3.07504937
66telomere maintenance via semi-conservative replication (GO:0032201)3.06013227
67protein retention in ER lumen (GO:0006621)3.05215631
68protein localization to endosome (GO:0036010)3.04874909
69regulation of podosome assembly (GO:0071801)3.03678059
70positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.02583692
71sister chromatid segregation (GO:0000819)3.02157481
72inner ear receptor cell differentiation (GO:0060113)3.01201547
73IMP metabolic process (GO:0046040)3.00170151
74regulation of hippo signaling (GO:0035330)2.99809194
75barbed-end actin filament capping (GO:0051016)2.98580761
76regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.97575507
77polyamine biosynthetic process (GO:0006596)2.97424415
78tRNA aminoacylation for protein translation (GO:0006418)2.96927696
79negative regulation of protein localization to plasma membrane (GO:1903077)2.96697040
80negative regulation of chromosome segregation (GO:0051985)2.95849356
81antibacterial humoral response (GO:0019731)2.95272388
82positive regulation of SMAD protein import into nucleus (GO:0060391)2.95082032
83retina vasculature morphogenesis in camera-type eye (GO:0061299)2.94166418
84establishment of chromosome localization (GO:0051303)2.94008432
85negative regulation of neural precursor cell proliferation (GO:2000178)2.93671282
86membrane lipid catabolic process (GO:0046466)2.92306066
87long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.90267493
88ribosome biogenesis (GO:0042254)2.89563481
89regulation of telomere maintenance via telomerase (GO:0032210)2.89310781
90Arp2/3 complex-mediated actin nucleation (GO:0034314)2.89227135
91positive regulation of receptor recycling (GO:0001921)2.88914532
92platelet degranulation (GO:0002576)2.88679962
93peptidyl-proline hydroxylation (GO:0019511)2.88115082
94negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.88112612
95negative regulation of sister chromatid segregation (GO:0033046)2.88112612
96negative regulation of mitotic sister chromatid separation (GO:2000816)2.88112612
97negative regulation of mitotic sister chromatid segregation (GO:0033048)2.88112612
98regulation of mitotic spindle organization (GO:0060236)2.87143023
99amino acid activation (GO:0043038)2.86413200
100tRNA aminoacylation (GO:0043039)2.86413200
101protein K6-linked ubiquitination (GO:0085020)2.86159619
102mitotic spindle assembly checkpoint (GO:0007094)2.85486496
103regulation of SMAD protein import into nucleus (GO:0060390)2.84963191
104spindle checkpoint (GO:0031577)2.84264419
105pentose-phosphate shunt (GO:0006098)2.84187830
106glucose 6-phosphate metabolic process (GO:0051156)2.84033896
107spindle assembly checkpoint (GO:0071173)2.83664326
108regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.81845778
109mitotic spindle checkpoint (GO:0071174)2.80822283
110regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.79171504
111membrane protein intracellular domain proteolysis (GO:0031293)2.78025715
112histone arginine methylation (GO:0034969)2.76724771
113regulation of cilium movement (GO:0003352)2.76580386
114negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.75151337
115kinetochore organization (GO:0051383)2.74642300
116peptidyl-arginine omega-N-methylation (GO:0035247)2.74306905
117DNA geometric change (GO:0032392)2.72897402
118regulation of chromosome segregation (GO:0051983)2.72889861
119telomere maintenance via recombination (GO:0000722)2.72878344
120kinetochore assembly (GO:0051382)2.72585296
121negative regulation of thymocyte apoptotic process (GO:0070244)2.72214758
122DNA duplex unwinding (GO:0032508)2.72060404
123notochord development (GO:0030903)2.71330253
124innate immune response in mucosa (GO:0002227)2.71014542
125nuclear envelope organization (GO:0006998)2.70655673
126regulation of centrosome cycle (GO:0046605)2.69577693
127heterochromatin organization (GO:0070828)2.69333237
128telomere maintenance via telomere lengthening (GO:0010833)2.69152275
129membrane invagination (GO:0010324)2.69012541
130regulation of mitotic metaphase/anaphase transition (GO:0030071)2.68971985
131negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.68423890
132NADPH regeneration (GO:0006740)2.68024404
133regulation of early endosome to late endosome transport (GO:2000641)2.66808186
134regulation of Golgi to plasma membrane protein transport (GO:0042996)2.66400944
135mitotic chromosome condensation (GO:0007076)2.66352310
136anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.65649439
137intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.65308315
138antimicrobial humoral response (GO:0019730)2.64782194
139chromatin remodeling at centromere (GO:0031055)2.64222022
140* peptide catabolic process (GO:0043171)2.63944226
141positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.63942240
142sphingolipid catabolic process (GO:0030149)2.63903661
143glycolytic process (GO:0006096)2.63748968
144interferon-gamma secretion (GO:0072643)2.62032152
145mitotic recombination (GO:0006312)2.60862845
146CENP-A containing nucleosome assembly (GO:0034080)2.60310762
147auditory receptor cell differentiation (GO:0042491)2.60041834
148glycoside metabolic process (GO:0016137)2.59489765
149myelin assembly (GO:0032288)2.59482386
150regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.59391469
151maturation of SSU-rRNA (GO:0030490)2.58489824
152mesodermal cell differentiation (GO:0048333)2.56472507
153low-density lipoprotein particle remodeling (GO:0034374)2.56066632
154negative regulation of smooth muscle cell migration (GO:0014912)2.56030650
155regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.54437066
156regulation of mitotic sister chromatid segregation (GO:0033047)2.54141319
157regulation of sister chromatid segregation (GO:0033045)2.54141319
158regulation of mitotic sister chromatid separation (GO:0010965)2.54141319
159viral entry into host cell (GO:0046718)2.53706600
160regulation of vitamin metabolic process (GO:0030656)2.53303442
161meiotic chromosome segregation (GO:0045132)2.53191391
162DNA strand renaturation (GO:0000733)2.52437614
163nucleoside diphosphate biosynthetic process (GO:0009133)2.51873050
164regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.51170680
165homotypic cell-cell adhesion (GO:0034109)2.50040074
166fatty acid elongation (GO:0030497)2.49991405
167cell adhesion mediated by integrin (GO:0033627)2.49770722
168ribosomal large subunit biogenesis (GO:0042273)2.49308845
169mitochondrial calcium ion transport (GO:0006851)2.48442336
170triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.48193583
171positive regulation of chromosome segregation (GO:0051984)2.47434328
172negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.47083354
173mismatch repair (GO:0006298)2.47073152
174intestinal absorption (GO:0050892)2.46735064
175pinocytosis (GO:0006907)2.46735000
176regulation of metalloenzyme activity (GO:0048552)2.46681682
177blastocyst development (GO:0001824)2.46551065
178positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.46228343
179microtubule depolymerization (GO:0007019)2.45994718
180nucleotide-sugar biosynthetic process (GO:0009226)2.45992768
181negative regulation of norepinephrine secretion (GO:0010700)2.45139920
182spliceosomal snRNP assembly (GO:0000387)2.44963809
183snRNA processing (GO:0016180)2.44944039
184positive regulation of Cdc42 GTPase activity (GO:0043089)2.44872103
185regulation of DNA damage checkpoint (GO:2000001)2.44490140
186regulation of nuclear cell cycle DNA replication (GO:0033262)2.44161716
187regulation of helicase activity (GO:0051095)2.43874850
188nucleotide-excision repair, DNA gap filling (GO:0006297)2.43588109
189vesicle targeting (GO:0006903)2.43394860
190ER to Golgi vesicle-mediated transport (GO:0006888)2.42792795
191regulation of cofactor metabolic process (GO:0051193)2.42439313
192regulation of coenzyme metabolic process (GO:0051196)2.42439313
193positive regulation of mitochondrial fission (GO:0090141)2.41764781
194regulation of platelet activation (GO:0010543)2.40996385
195ether lipid metabolic process (GO:0046485)2.39130440
196alpha-linolenic acid metabolic process (GO:0036109)2.37068191
197positive regulation of focal adhesion assembly (GO:0051894)2.35529311
198positive regulation of cell junction assembly (GO:1901890)2.35529311
199hair cell differentiation (GO:0035315)2.35378132
200activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.34655456

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.98303050
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.39319075
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.00132117
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.58293697
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.30011932
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.16713963
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.12050018
8CLOCK_20551151_ChIP-Seq_293T_Human2.95671847
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.89005469
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.85338732
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.76827724
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66484375
13AR_21909140_ChIP-Seq_LNCAP_Human2.65258732
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.59579351
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.59511348
16GATA2_21666600_ChIP-Seq_HMVEC_Human2.56941171
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.48922168
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.48284256
19NANOG_18555785_ChIP-Seq_MESCs_Mouse2.45413419
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.39166073
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.36883604
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.32437067
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.27592053
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.26368519
25ETS1_20019798_ChIP-Seq_JURKAT_Human2.22248183
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.21434960
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15599024
28EST1_17652178_ChIP-ChIP_JURKAT_Human2.14356918
29ELK3_25401928_ChIP-Seq_HUVEC_Human2.04539818
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02960597
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.02922126
32* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.01794036
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00559713
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.99067051
35XRN2_22483619_ChIP-Seq_HELA_Human1.97288885
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96198405
37* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93819489
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93515723
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.90509834
40SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.90396180
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.88072051
42NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.87723367
43IRF8_21731497_ChIP-ChIP_J774_Mouse1.87693116
44GATA1_22383799_ChIP-Seq_G1ME_Mouse1.83514908
45PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.82611959
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.80916209
47* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78343168
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73161885
49* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.72036979
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.67230014
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.65812561
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.65745560
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64620885
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64548691
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.62276991
56* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61704381
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.61631790
58DCP1A_22483619_ChIP-Seq_HELA_Human1.61433098
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.60541030
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.58672252
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.58589005
62SOX2_20726797_ChIP-Seq_SW620_Human1.58115233
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.57151139
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56736265
65NRF2_20460467_ChIP-Seq_MEFs_Mouse1.55259781
66NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.55259781
67GATA2_19941826_ChIP-Seq_K562_Human1.53896586
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53828613
69GABP_19822575_ChIP-Seq_HepG2_Human1.53435227
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.53228668
71* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.52566957
72TCF3_18692474_ChIP-Seq_MEFs_Mouse1.51873205
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.49657504
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.48695739
75MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48140280
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.46532680
77HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44790703
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43845136
79VDR_23849224_ChIP-Seq_CD4+_Human1.42386139
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42258202
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42132581
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40676598
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40488928
84* GATA1_19941827_ChIP-Seq_MEL_Mouse1.40423863
85ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39734748
86SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39118533
87TTF2_22483619_ChIP-Seq_HELA_Human1.38250302
88NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.37637295
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36914084
90GATA4_21415370_ChIP-Seq_HL-1_Mouse1.35773888
91FOXP3_21729870_ChIP-Seq_TREG_Human1.33043433
92TRIM28_21343339_ChIP-Seq_HEK293_Human1.31627965
93ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31604866
94NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.30642418
95LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30555818
96TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30467353
97KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29489299
98SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29071148
99ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.28768199
100GATA1_19941826_ChIP-Seq_K562_Human1.28431209
101SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.27048104
102SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.27048104
103GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26765525
104ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26605051
105PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26486242
106NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.26467494
107KDM5A_27292631_Chip-Seq_BREAST_Human1.26362232
108IRF8_27001747_Chip-Seq_BMDM_Mouse1.26054931
109TFEB_21752829_ChIP-Seq_HELA_Human1.25555197
110* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24688181
111NCOR1_26117541_ChIP-Seq_K562_Human1.24002017
112KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.23940391
113KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.23940391
114KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.23940391
115PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.23895672
116CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23685629
117ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23650533
118GATA6_25053715_ChIP-Seq_YYC3_Human1.22731925
119SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21775811
120SRF_21415370_ChIP-Seq_HL-1_Mouse1.21371647
121* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.21153937
122BRD4_25478319_ChIP-Seq_HGPS_Human1.20883170
123ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20430826
124GATA4_25053715_ChIP-Seq_YYC3_Human1.19350042
125PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.19045449
126HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18725323
127TCF3_18692474_ChIP-Seq_MESCs_Mouse1.17190999
128ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16989386
129ELK1_19687146_ChIP-ChIP_HELA_Human1.16523113
130DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16303173
131TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15862097
132CIITA_25753668_ChIP-Seq_RAJI_Human1.15807033
133SCL_19346495_ChIP-Seq_HPC-7_Human1.15726453
134SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.15394548
135SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14849912
136* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14429167
137RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14273581
138FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13448712
139VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12736481
140* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11645146
141GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11468019
142CDX2_20551321_ChIP-Seq_CACO-2_Human1.10512724
143NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08558050
144NANOG_21062744_ChIP-ChIP_HESCs_Human1.08460059
145DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07240600
146SOX2_18692474_ChIP-Seq_MEFs_Mouse1.07222012
147NANOG_16153702_ChIP-ChIP_HESCs_Human1.06753901
148ELK4_26923725_Chip-Seq_MESODERM_Mouse1.06065834
149CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05315926
150CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.05196249
151FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04435319
152RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04200767
153* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02993395
154EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.02569365
155OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01930693
156TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01594225
157RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01263552
158* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99795167
159WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99454948
160HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98641664
161HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98422616
162ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97155603
163ATF3_27146783_Chip-Seq_COLON_Human0.96459096
164SOX17_20123909_ChIP-Seq_XEN_Mouse0.95365808
165* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93879628
166SOX2_18692474_ChIP-Seq_MESCs_Mouse0.92556085
167NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90922920
168NANOG_18692474_ChIP-Seq_MEFs_Mouse0.90192618
169HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89924033
170RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88882986
171TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88654434
172NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.86757828
173MYC_22102868_ChIP-Seq_BL_Human0.86145520

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology5.05495412
2MP0003693_abnormal_embryo_hatching3.75586499
3MP0003111_abnormal_nucleus_morphology3.72573781
4MP0004957_abnormal_blastocyst_morpholog3.15646372
5MP0010094_abnormal_chromosome_stability3.00558719
6MP0003077_abnormal_cell_cycle2.80004019
7MP0008004_abnormal_stomach_pH2.74760018
8MP0010352_gastrointestinal_tract_polyps2.71170645
9MP0000465_gastrointestinal_hemorrhage2.66488013
10MP0008438_abnormal_cutaneous_collagen2.55703538
11MP0002877_abnormal_melanocyte_morpholog2.54292447
12MP0003705_abnormal_hypodermis_morpholog2.54126006
13MP0010030_abnormal_orbit_morphology2.42995635
14MP0008058_abnormal_DNA_repair2.21005191
15MP0005058_abnormal_lysosome_morphology2.16778170
16MP0000537_abnormal_urethra_morphology2.12587443
17MP0008932_abnormal_embryonic_tissue2.09649792
18MP0008007_abnormal_cellular_replicative2.07044110
19MP0005377_hearing/vestibular/ear_phenot2.02566141
20MP0003878_abnormal_ear_physiology2.02566141
21MP0003941_abnormal_skin_development2.01865788
22MP0003566_abnormal_cell_adhesion1.97983023
23MP0005360_urolithiasis1.93408651
24MP0003300_gastrointestinal_ulcer1.88860865
25MP0001730_embryonic_growth_arrest1.87820242
26MP0008057_abnormal_DNA_replication1.87105320
27MP0001879_abnormal_lymphatic_vessel1.78843537
28MP0004272_abnormal_basement_membrane1.78683024
29MP0003806_abnormal_nucleotide_metabolis1.74825912
30MP0010307_abnormal_tumor_latency1.68130191
31MP0001672_abnormal_embryogenesis/_devel1.67870064
32MP0005380_embryogenesis_phenotype1.67870064
33MP0000350_abnormal_cell_proliferation1.62560104
34MP0009840_abnormal_foam_cell1.62100105
35MP0003984_embryonic_growth_retardation1.61368307
36MP0006054_spinal_hemorrhage1.60837093
37MP0002088_abnormal_embryonic_growth/wei1.58722019
38MP0003123_paternal_imprinting1.56791929
39MP0000490_abnormal_crypts_of1.55615295
40MP0003091_abnormal_cell_migration1.52052959
41MP0001666_abnormal_nutrient_absorption1.51633882
42MP0000343_altered_response_to1.51308710
43MP0002086_abnormal_extraembryonic_tissu1.49855866
44MP0005275_abnormal_skin_tensile1.49479972
45MP0004197_abnormal_fetal_growth/weight/1.49150003
46MP0009764_decreased_sensitivity_to1.47879497
47MP0001697_abnormal_embryo_size1.47369825
48MP0002084_abnormal_developmental_patter1.47195566
49MP0005623_abnormal_meninges_morphology1.46577466
50MP0002085_abnormal_embryonic_tissue1.46447288
51MP0003786_premature_aging1.43285015
52MP0010368_abnormal_lymphatic_system1.42850525
53MP0003828_pulmonary_edema1.42473813
54MP0000566_synostosis1.41862655
55MP0002080_prenatal_lethality1.36980247
56MP0010155_abnormal_intestine_physiology1.36605099
57MP0003718_maternal_effect1.36363911
58MP0003303_peritoneal_inflammation1.35753136
59MP0004264_abnormal_extraembryonic_tissu1.34212480
60MP0005257_abnormal_intraocular_pressure1.33982036
61MP0003567_abnormal_fetal_cardiomyocyte1.33209717
62MP0004133_heterotaxia1.31611612
63MP0005023_abnormal_wound_healing1.31273514
64MP0008775_abnormal_heart_ventricle1.30715403
65MP0001293_anophthalmia1.28843440
66MP0008260_abnormal_autophagy1.26759619
67MP0005365_abnormal_bile_salt1.25583384
68MP0002653_abnormal_ependyma_morphology1.24689027
69MP0005503_abnormal_tendon_morphology1.24333361
70MP0001958_emphysema1.23315325
71MP0005501_abnormal_skin_physiology1.20291413
72MP0002111_abnormal_tail_morphology1.18549053
73MP0005076_abnormal_cell_differentiation1.16348147
74MP0003119_abnormal_digestive_system1.16093393
75MP0009053_abnormal_anal_canal1.14807363
76MP0004233_abnormal_muscle_weight1.13836643
77MP0002089_abnormal_postnatal_growth/wei1.10943213
78MP0003183_abnormal_peptide_metabolism1.09118839
79MP0002396_abnormal_hematopoietic_system1.08227052
80MP0003115_abnormal_respiratory_system1.07855418
81MP0003724_increased_susceptibility_to1.07419244
82MP0004808_abnormal_hematopoietic_stem1.04506860
83MP0004147_increased_porphyrin_level1.03496001
84MP0008789_abnormal_olfactory_epithelium1.03087788
85MP0003283_abnormal_digestive_organ1.00842060
86MP0005409_darkened_coat_color0.98342255
87MP0003937_abnormal_limbs/digits/tail_de0.98123221
88MP0005171_absent_coat_pigmentation0.96071929
89MP0002102_abnormal_ear_morphology0.94714453
90MP0003448_altered_tumor_morphology0.94579797
91MP0000313_abnormal_cell_death0.94243899
92MP0004134_abnormal_chest_morphology0.93535238
93MP0005499_abnormal_olfactory_system0.92722717
94MP0005394_taste/olfaction_phenotype0.92722717
95MP0005165_increased_susceptibility_to0.92532402
96MP0009697_abnormal_copulation0.92381735
97MP0002060_abnormal_skin_morphology0.91770927
98MP0001915_intracranial_hemorrhage0.91668766
99MP0003453_abnormal_keratinocyte_physiol0.90751749
100MP0004084_abnormal_cardiac_muscle0.90633908
101MP0000249_abnormal_blood_vessel0.88983620
102MP0001853_heart_inflammation0.88377937
103MP0001849_ear_inflammation0.87819932
104MP0000428_abnormal_craniofacial_morphol0.87803175
105MP0005508_abnormal_skeleton_morphology0.87750820
106MP0000432_abnormal_head_morphology0.87680424
107MP0005197_abnormal_uvea_morphology0.86435094
108MP0003950_abnormal_plasma_membrane0.85527821
109MP0005193_abnormal_anterior_eye0.84887332
110MP0010234_abnormal_vibrissa_follicle0.84402340
111MP0010678_abnormal_skin_adnexa0.83728643
112MP0003121_genomic_imprinting0.83109534
113MP0001663_abnormal_digestive_system0.82614808
114MP0002282_abnormal_trachea_morphology0.82562393
115MP0003755_abnormal_palate_morphology0.80398192
116MP0000762_abnormal_tongue_morphology0.80113619
117MP0003385_abnormal_body_wall0.79473770
118MP0005248_abnormal_Harderian_gland0.79247468
119MP0000733_abnormal_muscle_development0.77955253
120MP0003279_aneurysm0.77875225
121MP0000358_abnormal_cell_content/0.77759450
122MP0003656_abnormal_erythrocyte_physiolo0.77433732
123MP0002697_abnormal_eye_size0.77400227
124MP0009384_cardiac_valve_regurgitation0.77224637
125MP0001614_abnormal_blood_vessel0.77038973
126MP0002796_impaired_skin_barrier0.75749434
127MP0005397_hematopoietic_system_phenotyp0.75239360
128MP0001545_abnormal_hematopoietic_system0.75239360
129MP0009763_increased_sensitivity_to0.74958704
130MP0000534_abnormal_ureter_morphology0.74893022
131MP0000516_abnormal_urinary_system0.74831891
132MP0005367_renal/urinary_system_phenotyp0.74831891
133MP0001542_abnormal_bone_strength0.74574775
134MP0000750_abnormal_muscle_regeneration0.74267973
135MP0000477_abnormal_intestine_morphology0.74259658
136MP0003186_abnormal_redox_activity0.74114268
137MP0008877_abnormal_DNA_methylation0.74053333
138MP0002128_abnormal_blood_circulation0.73766062
139MP0002233_abnormal_nose_morphology0.73320923
140MP0003221_abnormal_cardiomyocyte_apopto0.73017485
141MP0003942_abnormal_urinary_system0.72119114
142MP0002092_abnormal_eye_morphology0.72103695
143MP0005621_abnormal_cell_physiology0.71969664
144MP0000858_altered_metastatic_potential0.71335767
145MP0005384_cellular_phenotype0.71300908
146MP0009765_abnormal_xenobiotic_induced0.69839188
147MP0004782_abnormal_surfactant_physiolog0.69591500
148MP0001851_eye_inflammation0.69589229
149MP0002132_abnormal_respiratory_system0.69580042
150MP0000049_abnormal_middle_ear0.69577592
151MP0000598_abnormal_liver_morphology0.69552208
152MP0002925_abnormal_cardiovascular_devel0.69160087
153MP0005083_abnormal_biliary_tract0.66934400
154MP0000383_abnormal_hair_follicle0.66614237
155MP0001216_abnormal_epidermal_layer0.66135205
156MP0001533_abnormal_skeleton_physiology0.66132585
157MP0004858_abnormal_nervous_system0.63459321
158MP0004947_skin_inflammation0.62486945
159MP0005451_abnormal_body_composition0.61930922

Predicted human phenotypes

RankGene SetZ-score
1Increased mean platelet volume (HP:0011877)6.43864435
2Abnormal platelet volume (HP:0011876)5.86313382
3Petechiae (HP:0000967)5.60542002
4Prolonged bleeding time (HP:0003010)5.50142599
5Menorrhagia (HP:0000132)5.10816533
6Purpura (HP:0000979)4.20900459
7Tetraparesis (HP:0002273)3.75419532
8Epistaxis (HP:0000421)3.61694694
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.45411858
10Impaired platelet aggregation (HP:0003540)3.42889501
11Abnormal platelet function (HP:0011869)3.42889501
12Birth length less than 3rd percentile (HP:0003561)3.39976525
13Selective tooth agenesis (HP:0001592)3.39711223
14Breast hypoplasia (HP:0003187)3.28520506
15Protrusio acetabuli (HP:0003179)3.21498413
16Chromsome breakage (HP:0040012)3.14683533
17Conjunctival telangiectasia (HP:0000524)3.12630607
18Premature rupture of membranes (HP:0001788)3.12579003
19Gingival bleeding (HP:0000225)2.92466584
20Ependymoma (HP:0002888)2.91243644
21Spastic diplegia (HP:0001264)2.91148306
22Abnormality of the vasculature of the conjunctiva (HP:0008054)2.86558226
23Cortical dysplasia (HP:0002539)2.80694979
24Dyschromatopsia (HP:0007641)2.80150447
25Cervical subluxation (HP:0003308)2.75383427
26Nausea (HP:0002018)2.74263052
27Aortic dissection (HP:0002647)2.71455216
28Absent radius (HP:0003974)2.71032436
29Disproportionate short-trunk short stature (HP:0003521)2.68718584
30Vacuolated lymphocytes (HP:0001922)2.66924973
31Absent forearm bone (HP:0003953)2.59360495
32Aplasia involving forearm bones (HP:0009822)2.59360495
33Patellar aplasia (HP:0006443)2.55200204
34Renal tubular acidosis (HP:0001947)2.53017550
35Metaphyseal cupping (HP:0003021)2.50397153
36Meckel diverticulum (HP:0002245)2.48815689
37Curly hair (HP:0002212)2.48443090
38Distal lower limb muscle weakness (HP:0009053)2.46349709
39Abnormal gallbladder physiology (HP:0012438)2.44145409
40Cholecystitis (HP:0001082)2.44145409
41Abnormality of the ileum (HP:0001549)2.43314922
42Neonatal short-limb short stature (HP:0008921)2.40731762
43Abnormality of the astrocytes (HP:0100707)2.37441856
44Astrocytoma (HP:0009592)2.37441856
45Breech presentation (HP:0001623)2.36862918
46Ureteral duplication (HP:0000073)2.36777833
47Reticulocytopenia (HP:0001896)2.35018832
48Abnormality of the labia minora (HP:0012880)2.33671136
49Aplasia/Hypoplasia of the patella (HP:0006498)2.33443272
50Ankle contracture (HP:0006466)2.32546103
51Spondylolisthesis (HP:0003302)2.31657380
52Abnormality of the anterior horn cell (HP:0006802)2.26254156
53Degeneration of anterior horn cells (HP:0002398)2.26254156
54Aplasia/hypoplasia of the humerus (HP:0006507)2.25926213
55Trismus (HP:0000211)2.25119265
56Aplasia/Hypoplasia of the uvula (HP:0010293)2.24936514
57Rough bone trabeculation (HP:0100670)2.24495700
58Hyperlipoproteinemia (HP:0010980)2.24420318
5911 pairs of ribs (HP:0000878)2.23199769
60Cutaneous melanoma (HP:0012056)2.22297936
61Small intestinal stenosis (HP:0012848)2.17628758
62Duodenal stenosis (HP:0100867)2.17628758
63Short humerus (HP:0005792)2.15197731
64Deviation of the thumb (HP:0009603)2.15175110
65Pulmonary artery stenosis (HP:0004415)2.13980110
66Abnormal umbilical cord blood vessels (HP:0011403)2.13601166
67Single umbilical artery (HP:0001195)2.13601166
68Abnormality of the fetal cardiovascular system (HP:0010948)2.13601166
69Agnosia (HP:0010524)2.13408042
70Glioma (HP:0009733)2.12679251
71Abnormality of the preputium (HP:0100587)2.10094147
72Carpal bone hypoplasia (HP:0001498)2.09974015
73Increased connective tissue (HP:0009025)2.09827603
74Abnormality of chromosome stability (HP:0003220)2.08069903
75Spontaneous hematomas (HP:0007420)2.07821385
76Hip dysplasia (HP:0001385)2.07019073
77Abnormality of the umbilical cord (HP:0010881)2.06859704
78Insidious onset (HP:0003587)2.06740513
79Termporal pattern (HP:0011008)2.06740513
80Hepatosplenomegaly (HP:0001433)2.06644714
81Osteolytic defects of the hand bones (HP:0009699)2.05741078
82Osteolytic defects of the phalanges of the hand (HP:0009771)2.05741078
83Missing ribs (HP:0000921)2.05447816
84Duplicated collecting system (HP:0000081)2.04737470
85Polyphagia (HP:0002591)2.04260394
86Follicular hyperkeratosis (HP:0007502)2.03326450
87Abnormality of glycolysis (HP:0004366)2.03246640
88Upper motor neuron abnormality (HP:0002127)2.02737399
89Shallow orbits (HP:0000586)2.00881389
90Flat acetabular roof (HP:0003180)2.00656135
91Slender long bone (HP:0003100)1.98977693
92Entropion (HP:0000621)1.97984382
93Ileus (HP:0002595)1.97124725
94Thin bony cortex (HP:0002753)1.95850622
95Abnormality of glutamine family amino acid metabolism (HP:0010902)1.95560282
96Colon cancer (HP:0003003)1.95246203
97Impulsivity (HP:0100710)1.95182524
98Abnormal pupillary function (HP:0007686)1.94756348
99Hypoplasia of the iris (HP:0007676)1.94539243
100Proximal placement of thumb (HP:0009623)1.93626255
101Shawl scrotum (HP:0000049)1.93622004
102Arterial tortuosity (HP:0005116)1.93478134
103Papillary thyroid carcinoma (HP:0002895)1.93338359
104Hypoplasia of the capital femoral epiphysis (HP:0003090)1.92724129
105Wrist flexion contracture (HP:0001239)1.92272212
106Muscle fibrillation (HP:0010546)1.90970607
107Hand muscle atrophy (HP:0009130)1.90700945
108Distal lower limb amyotrophy (HP:0008944)1.90688574
109Vertebral compression fractures (HP:0002953)1.87471975
110Bruising susceptibility (HP:0000978)1.86376902
111Upper limb muscle weakness (HP:0003484)1.85427854
112Spinal muscular atrophy (HP:0007269)1.84825063
113Medulloblastoma (HP:0002885)1.84398265
114Prolonged neonatal jaundice (HP:0006579)1.83806994
115Wide cranial sutures (HP:0010537)1.83517777
116Tongue fasciculations (HP:0001308)1.82701921
117Mesomelia (HP:0003027)1.82683768
118High anterior hairline (HP:0009890)1.81976806
119Abdominal distention (HP:0003270)1.81165484
120Atrophic scars (HP:0001075)1.81128949
121Increased IgM level (HP:0003496)1.81051143
122Neoplasm of the pancreas (HP:0002894)1.80820617
123Large earlobe (HP:0009748)1.80806409
124Abnormality of abdominal situs (HP:0011620)1.80758855
125Abdominal situs inversus (HP:0003363)1.80758855
126Abnormal tarsal ossification (HP:0008369)1.80444285
127Abnormality of reticulocytes (HP:0004312)1.80436337
128Facial cleft (HP:0002006)1.80295181
129Abnormality of the acetabulum (HP:0003170)1.79643920
130Abnormality of dentin (HP:0010299)1.78871722
131Abnormal number of incisors (HP:0011064)1.77215379
132Soft skin (HP:0000977)1.76881835
133Patent foramen ovale (HP:0001655)1.76816280
134Abnormality of the calcaneus (HP:0008364)1.75608160
135Ectopic kidney (HP:0000086)1.74570808
136Cerebral aneurysm (HP:0004944)1.74037978
137Abnormal trabecular bone morphology (HP:0100671)1.73463143
138Upper limb amyotrophy (HP:0009129)1.72798308
139Distal upper limb amyotrophy (HP:0007149)1.72798308
140Vertebral hypoplasia (HP:0008417)1.72632243
141Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.72632243
142Long foot (HP:0001833)1.72115558
143Abnormality of the periventricular white matter (HP:0002518)1.71843490
144Dysostosis multiplex (HP:0000943)1.70250416
145Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.69798578
146Cupped ribs (HP:0000887)1.69680629
147Alopecia of scalp (HP:0002293)1.69410690
148Breast aplasia (HP:0100783)1.68510840
149Absent thumb (HP:0009777)1.67808846
150Blue sclerae (HP:0000592)1.67460674
151Thyroid carcinoma (HP:0002890)1.66963170
152Dilatation of the ascending aorta (HP:0005111)1.66610195
153Steatorrhea (HP:0002570)1.66326385
154Skull defect (HP:0001362)1.65936437
155Myocardial infarction (HP:0001658)1.65309096
156Abnormal vertebral ossification (HP:0100569)1.64950449
157Abnormality of the carotid arteries (HP:0005344)1.64789432
158Megaloblastic anemia (HP:0001889)1.64768953
159Thrombocytosis (HP:0001894)1.64726335
160Abnormality of the duodenum (HP:0002246)1.64472630
161Thick nail (HP:0001805)1.64362892
162Vascular tortuosity (HP:0004948)1.63632619
163Fragile skin (HP:0001030)1.63483121
164Right ventricular cardiomyopathy (HP:0011663)1.63218528
165Sloping forehead (HP:0000340)1.63058193
166Hydroxyprolinuria (HP:0003080)1.62644894
167Abnormality of proline metabolism (HP:0010907)1.62644894
168Abnormal auditory evoked potentials (HP:0006958)1.60447842
169Platyspondyly (HP:0000926)1.59453672
170Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.59196523
171Short 4th metacarpal (HP:0010044)1.59196523
172Abnormality of pyrimidine metabolism (HP:0004353)1.59148811
173Short ribs (HP:0000773)1.59009822
174Calcaneovalgus deformity (HP:0001848)1.58947133
175Protuberant abdomen (HP:0001538)1.58654630
176Absent epiphyses (HP:0010577)1.58577675
177Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.58577675
178Aplasia/Hypoplasia of the breasts (HP:0010311)1.58434643
179Conjugated hyperbilirubinemia (HP:0002908)1.57551068
180Renal duplication (HP:0000075)1.57271018
181Abnormality of the proximal phalanges of the hand (HP:0009834)1.56975866
182Paralysis (HP:0003470)1.56218568
183Aplasia/Hypoplasia of the clavicles (HP:0006710)1.56090081
184Malnutrition (HP:0004395)1.55693227
185Abnormality of the odontoid process (HP:0003310)1.55203887
186Cerebral hemorrhage (HP:0001342)1.54804080
187Thickened calvaria (HP:0002684)1.52574944
188Decreased skull ossification (HP:0004331)1.52342185
189Erythema (HP:0010783)1.52307459

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.26915879
2BUB14.03186246
3EPHB23.26216795
4WEE13.20754883
5TTK2.73421847
6STK38L2.44379063
7CDC72.35402158
8SIK32.34923968
9MYLK2.32675009
10EIF2AK12.31968651
11LMTK22.30444725
12NEK12.21861581
13ZAK2.14288239
14TESK12.13362108
15CDK122.11169260
16NEK22.10784638
17BCR2.07794868
18NEK92.03864205
19AKT31.99594805
20EPHA31.87459736
21TIE11.81950195
22RPS6KB21.80315374
23PLK11.75886012
24TRIM281.69906462
25PAK41.65917419
26TSSK61.63366286
27IRAK31.62090305
28TESK21.61202409
29LATS11.60690493
30BRSK21.54277767
31MAP4K21.53616316
32TNIK1.48763737
33AURKB1.47355812
34NTRK11.47222699
35DDR21.45845249
36CDK71.45055443
37PLK41.44443420
38MAP3K81.41492242
39CDK61.40591950
40EEF2K1.38566704
41STK31.38478267
42ATR1.37817713
43SRPK11.36303907
44CSF1R1.35977994
45PDK41.34799172
46PDK31.34799172
47PKN21.31324754
48LATS21.30537567
49STK101.28884785
50CHEK21.24636695
51KSR11.24259520
52PLK31.23224855
53EIF2AK31.22340037
54FGR1.21250998
55MATK1.21201624
56RIPK11.20923986
57PASK1.20484068
58SIK21.19817864
59MST41.18733911
60TAOK21.16676882
61EIF2AK21.16313145
62INSRR1.13912353
63EPHB11.12164954
64PIM21.11894494
65PDK21.08581278
66MAP3K101.08396091
67AURKA1.06158017
68RPS6KA41.05672456
69CHEK11.05113722
70DAPK31.03860605
71SCYL21.01377558
72BTK1.00821815
73CDK40.99993425
74NME20.97953642
75STK40.96597235
76BRSK10.96158216
77TTN0.95432752
78PRKCI0.94948074
79MET0.94887847
80PAK10.93454604
81FGFR10.92804139
82BMPR20.92648137
83LIMK10.91993556
84PTK2B0.91522626
85PIM10.88896573
86PIK3CG0.88769561
87ACVR1B0.88252748
88TEC0.87849729
89BMX0.86276403
90TLK10.85445222
91DYRK30.84896112
92MAP3K140.84664785
93MTOR0.81230317
94AKT20.80154963
95MAPKAPK30.80134589
96BRAF0.77195123
97MAP2K70.76592484
98MAP3K30.76007101
99CDK90.74283760
100TGFBR10.73887958
101PRKG20.73180088
102VRK10.72622159
103KDR0.72502901
104CDK190.72466014
105BLK0.71335371
106RET0.71123948
107ZAP700.68204299
108STK240.67410759
109TRIB30.66922686
110STK160.66711701
111LRRK20.64265269
112PLK20.63850346
113PTK20.63262067
114PAK20.62459489
115CDK20.62155048
116CDK140.61071889
117ATM0.60864960
118PTK60.60673873
119ERBB20.60062478
120FGFR40.59189190
121PDGFRA0.57821572
122CSNK1G30.56943441
123PRPF4B0.56431844
124FLT30.55364210
125DYRK1B0.55326192
126MKNK10.54921195
127MAP3K60.54518749
128RAF10.51893667
129ERBB30.50407936
130ICK0.48957325
131PRKD30.48669354
132CDK180.47997637
133NME10.47476172
134FER0.47111318
135BMPR1B0.47076028
136CDK80.47055696
137CDK10.45614652
138BRD40.45068915
139BCKDK0.44406878
140ABL20.43765208
141LYN0.42435493
142MAP3K50.42313489
143CSNK2A10.41595629
144SRC0.41279301
145PDGFRB0.40717821
146CSNK2A20.39941422
147ARAF0.39369555
148WNK30.37488144
149CDK150.37105123
150TRPM70.34002613
151STK390.33768305
152MST1R0.33283061
153ILK0.33183176
154DYRK20.32729040
155CDK11A0.32384520
156DAPK10.31854561
157YES10.31570699
158MAPKAPK20.30901650
159ERBB40.30577578

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.77453652
2Mismatch repair_Homo sapiens_hsa034303.33251577
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.14273009
4One carbon pool by folate_Homo sapiens_hsa006703.04274678
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.01340319
6RNA transport_Homo sapiens_hsa030132.79500940
7Proteasome_Homo sapiens_hsa030502.76103359
8Base excision repair_Homo sapiens_hsa034102.62905119
9Cell cycle_Homo sapiens_hsa041102.43464815
10Steroid biosynthesis_Homo sapiens_hsa001002.27398678
11Spliceosome_Homo sapiens_hsa030402.24555312
12Nucleotide excision repair_Homo sapiens_hsa034202.18279701
13Platelet activation_Homo sapiens_hsa046112.16652935
14RNA polymerase_Homo sapiens_hsa030202.11716381
15Homologous recombination_Homo sapiens_hsa034402.09093402
16Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.99012498
17Fanconi anemia pathway_Homo sapiens_hsa034601.92357656
18p53 signaling pathway_Homo sapiens_hsa041151.92292057
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.86856835
20Other glycan degradation_Homo sapiens_hsa005111.84596638
21Pyrimidine metabolism_Homo sapiens_hsa002401.82338508
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.78219198
23Sulfur metabolism_Homo sapiens_hsa009201.77587241
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.67999986
25Fructose and mannose metabolism_Homo sapiens_hsa000511.65958045
26Renin-angiotensin system_Homo sapiens_hsa046141.57726009
27Fatty acid elongation_Homo sapiens_hsa000621.56531539
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54510356
29Vibrio cholerae infection_Homo sapiens_hsa051101.53141275
30Pancreatic secretion_Homo sapiens_hsa049721.50781356
31Starch and sucrose metabolism_Homo sapiens_hsa005001.48762692
32Ribosome_Homo sapiens_hsa030101.44646866
33Vitamin digestion and absorption_Homo sapiens_hsa049771.44298171
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.42526221
35Biosynthesis of amino acids_Homo sapiens_hsa012301.42035508
36Non-homologous end-joining_Homo sapiens_hsa034501.39188354
37Galactose metabolism_Homo sapiens_hsa000521.37325145
38Carbon metabolism_Homo sapiens_hsa012001.31167295
39mRNA surveillance pathway_Homo sapiens_hsa030151.30327128
40Pentose phosphate pathway_Homo sapiens_hsa000301.29447922
41Salmonella infection_Homo sapiens_hsa051321.27893704
42Alcoholism_Homo sapiens_hsa050341.23777432
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.23475183
44Glutathione metabolism_Homo sapiens_hsa004801.22502898
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.20810444
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.19834318
47Small cell lung cancer_Homo sapiens_hsa052221.19816556
48Basal transcription factors_Homo sapiens_hsa030221.17418413
49Pancreatic cancer_Homo sapiens_hsa052121.15121390
50Lysosome_Homo sapiens_hsa041421.14061779
51Hippo signaling pathway_Homo sapiens_hsa043901.11106133
52Fat digestion and absorption_Homo sapiens_hsa049751.08631346
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07420362
54RNA degradation_Homo sapiens_hsa030181.06579441
55ECM-receptor interaction_Homo sapiens_hsa045121.03188002
56Basal cell carcinoma_Homo sapiens_hsa052171.02003881
57Purine metabolism_Homo sapiens_hsa002301.01089541
58Systemic lupus erythematosus_Homo sapiens_hsa053221.01020548
59Protein digestion and absorption_Homo sapiens_hsa049740.99320184
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98940511
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98577048
62Mineral absorption_Homo sapiens_hsa049780.97891763
63Adherens junction_Homo sapiens_hsa045200.95947115
64Viral carcinogenesis_Homo sapiens_hsa052030.95817517
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93310957
66Selenocompound metabolism_Homo sapiens_hsa004500.93250553
67Epstein-Barr virus infection_Homo sapiens_hsa051690.91967784
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88896818
69Bladder cancer_Homo sapiens_hsa052190.87213293
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86666555
71Glycerolipid metabolism_Homo sapiens_hsa005610.83976777
72MicroRNAs in cancer_Homo sapiens_hsa052060.82902041
73Amoebiasis_Homo sapiens_hsa051460.82716215
74Arginine and proline metabolism_Homo sapiens_hsa003300.79286221
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.78632945
76Fatty acid metabolism_Homo sapiens_hsa012120.78107045
77Tight junction_Homo sapiens_hsa045300.77017381
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75975905
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75235074
80Gap junction_Homo sapiens_hsa045400.71969495
81Folate biosynthesis_Homo sapiens_hsa007900.71562350
82Legionellosis_Homo sapiens_hsa051340.71048745
83HTLV-I infection_Homo sapiens_hsa051660.70582941
84TGF-beta signaling pathway_Homo sapiens_hsa043500.69797544
85Hedgehog signaling pathway_Homo sapiens_hsa043400.69563267
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69173200
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68837248
88Phagosome_Homo sapiens_hsa041450.65289508
89Endocytosis_Homo sapiens_hsa041440.65286211
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.64685169
91Pyruvate metabolism_Homo sapiens_hsa006200.62710216
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.61612117
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61299181
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59455789
95PPAR signaling pathway_Homo sapiens_hsa033200.59435852
96HIF-1 signaling pathway_Homo sapiens_hsa040660.58380231
97Hematopoietic cell lineage_Homo sapiens_hsa046400.57290907
98Hepatitis B_Homo sapiens_hsa051610.57023247
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.56497448
100Herpes simplex infection_Homo sapiens_hsa051680.56395351
101Focal adhesion_Homo sapiens_hsa045100.54954591
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53671385
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52859182
104Apoptosis_Homo sapiens_hsa042100.52769252
105Arachidonic acid metabolism_Homo sapiens_hsa005900.52741156
106Oocyte meiosis_Homo sapiens_hsa041140.50458737
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49682785
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49516340
109Collecting duct acid secretion_Homo sapiens_hsa049660.48577564
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48551737
111Thyroid cancer_Homo sapiens_hsa052160.47791205
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45580833
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45568422
114Lysine degradation_Homo sapiens_hsa003100.45477809
115Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44653279
116Chemokine signaling pathway_Homo sapiens_hsa040620.42877568
117Proteoglycans in cancer_Homo sapiens_hsa052050.41627433
118Pathways in cancer_Homo sapiens_hsa052000.38978535
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38470315
120Non-small cell lung cancer_Homo sapiens_hsa052230.38193505
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37729072
122N-Glycan biosynthesis_Homo sapiens_hsa005100.37207211
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36545403
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33298157
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.33083407
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32875696
127Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32458998
128Metabolic pathways_Homo sapiens_hsa011000.31946707
129Vitamin B6 metabolism_Homo sapiens_hsa007500.31923637
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31697520
131Malaria_Homo sapiens_hsa051440.30723413
132Viral myocarditis_Homo sapiens_hsa054160.29925288
133Antigen processing and presentation_Homo sapiens_hsa046120.29246870
134Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29095387
135RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29053153
136Prostate cancer_Homo sapiens_hsa052150.28790636
137Melanoma_Homo sapiens_hsa052180.26711210
138Notch signaling pathway_Homo sapiens_hsa043300.26338238
139Shigellosis_Homo sapiens_hsa051310.26038620
140Chronic myeloid leukemia_Homo sapiens_hsa052200.25888543
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25734784
142Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24783665
143Sphingolipid metabolism_Homo sapiens_hsa006000.23002784
144alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22860203

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