XPA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.71385044
2ribosomal small subunit assembly (GO:0000028)6.22512038
3viral transcription (GO:0019083)5.74026107
4DNA deamination (GO:0045006)5.50302547
5translational termination (GO:0006415)5.49331471
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.07079568
7cotranslational protein targeting to membrane (GO:0006613)4.98400222
8protein targeting to ER (GO:0045047)4.94579321
9protein localization to endoplasmic reticulum (GO:0070972)4.77440459
10establishment of protein localization to endoplasmic reticulum (GO:0072599)4.68791164
11translational elongation (GO:0006414)4.66180120
12ribosomal small subunit biogenesis (GO:0042274)4.63624509
13antigen processing and presentation via MHC class Ib (GO:0002475)4.58729715
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.26460203
15viral life cycle (GO:0019058)4.24982986
16cellular protein complex disassembly (GO:0043624)4.12045669
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.09593637
18mitochondrial respiratory chain complex assembly (GO:0033108)3.85795594
19response to pheromone (GO:0019236)3.82017551
20translational initiation (GO:0006413)3.80215644
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.78868752
22positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.76592933
23energy coupled proton transport, down electrochemical gradient (GO:0015985)3.68351838
24ATP synthesis coupled proton transport (GO:0015986)3.68351838
25pyrimidine nucleobase catabolic process (GO:0006208)3.63824647
26activated T cell proliferation (GO:0050798)3.62738155
27cytochrome complex assembly (GO:0017004)3.60199430
28response to interferon-beta (GO:0035456)3.60059236
29chaperone-mediated protein transport (GO:0072321)3.57642417
30electron transport chain (GO:0022900)3.49777557
31GPI anchor metabolic process (GO:0006505)3.49415150
32respiratory electron transport chain (GO:0022904)3.47161777
33nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.45307568
34protein complex disassembly (GO:0043241)3.44522755
35protein neddylation (GO:0045116)3.42951823
36protein localization to cilium (GO:0061512)3.41488326
37cellular ketone body metabolic process (GO:0046950)3.39768772
38neuron fate determination (GO:0048664)3.38647062
39positive regulation of gamma-delta T cell activation (GO:0046645)3.36949355
40macromolecular complex disassembly (GO:0032984)3.35223822
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.32614820
42antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.32614820
43platelet dense granule organization (GO:0060155)3.30781251
44exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.30534247
45mannosylation (GO:0097502)3.28202120
46ubiquinone biosynthetic process (GO:0006744)3.26778148
47establishment of protein localization to mitochondrial membrane (GO:0090151)3.26442612
48protein targeting to membrane (GO:0006612)3.26136721
49axoneme assembly (GO:0035082)3.23920768
50translation (GO:0006412)3.22644885
51cellular response to zinc ion (GO:0071294)3.22263093
52regulation of necroptotic process (GO:0060544)3.20091043
53protein-cofactor linkage (GO:0018065)3.19761068
54positive regulation of protein homodimerization activity (GO:0090073)3.18409978
55ubiquinone metabolic process (GO:0006743)3.16702482
56regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.15435905
57indolalkylamine metabolic process (GO:0006586)3.14530324
58ribosomal large subunit biogenesis (GO:0042273)3.12481496
59definitive hemopoiesis (GO:0060216)3.11441033
60nonmotile primary cilium assembly (GO:0035058)3.10830223
61GPI anchor biosynthetic process (GO:0006506)3.09423307
62indole-containing compound catabolic process (GO:0042436)3.07009949
63indolalkylamine catabolic process (GO:0046218)3.07009949
64tryptophan catabolic process (GO:0006569)3.07009949
65epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.06203145
66maturation of SSU-rRNA (GO:0030490)3.05029836
67neutrophil activation involved in immune response (GO:0002283)3.04553029
68ketone body metabolic process (GO:1902224)2.99069692
69anterograde synaptic vesicle transport (GO:0048490)2.96702564
70mature B cell differentiation involved in immune response (GO:0002313)2.95023957
71antigen processing and presentation of endogenous antigen (GO:0019883)2.94327162
72intraciliary transport (GO:0042073)2.93664349
73nucleobase catabolic process (GO:0046113)2.93417821
74cullin deneddylation (GO:0010388)2.93289529
75response to type I interferon (GO:0034340)2.92397212
76type I interferon signaling pathway (GO:0060337)2.91180690
77cellular response to type I interferon (GO:0071357)2.91180690
78regulation of mitochondrial translation (GO:0070129)2.91049298
79behavioral response to nicotine (GO:0035095)2.90619632
80positive regulation of T cell mediated cytotoxicity (GO:0001916)2.89482639
81cellular response to interferon-beta (GO:0035458)2.89348286
82sequestering of actin monomers (GO:0042989)2.89272941
83kynurenine metabolic process (GO:0070189)2.88815809
84nuclear-transcribed mRNA catabolic process (GO:0000956)2.88191457
85CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.88107970
86negative regulation of response to food (GO:0032096)2.87614840
87negative regulation of appetite (GO:0032099)2.87614840
88proteasome assembly (GO:0043248)2.87577551
89base-excision repair, AP site formation (GO:0006285)2.87324668
90negative regulation of necroptotic process (GO:0060546)2.86758213
91regulation of interleukin-12 biosynthetic process (GO:0045075)2.86412742
92T-helper 1 type immune response (GO:0042088)2.85765173
93respiratory burst (GO:0045730)2.84791639
94positive regulation of mitochondrial fission (GO:0090141)2.83761800
95water-soluble vitamin biosynthetic process (GO:0042364)2.83675443
96preassembly of GPI anchor in ER membrane (GO:0016254)2.83590468
97response to interferon-alpha (GO:0035455)2.83066739
98positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.82907374
99programmed necrotic cell death (GO:0097300)2.82667162
100maturation of 5.8S rRNA (GO:0000460)2.82297319
101protein deneddylation (GO:0000338)2.77038524
102signal peptide processing (GO:0006465)2.76847714
103lymph node development (GO:0048535)2.76839523
104mRNA catabolic process (GO:0006402)2.75839696
105defense response to protozoan (GO:0042832)2.75384371
106negative regulation of transcription by competitive promoter binding (GO:0010944)2.73464647
107tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.70347340
108RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.70347340
109regulation of T cell mediated cytotoxicity (GO:0001914)2.69738740
110GTP biosynthetic process (GO:0006183)2.69617635
111negative regulation of telomere maintenance (GO:0032205)2.68730079
112antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.67245974
113tachykinin receptor signaling pathway (GO:0007217)2.66606936
114RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.66591295
115positive regulation of amino acid transport (GO:0051957)2.66014873
116positive regulation of DNA recombination (GO:0045911)2.65248123
117retinal rod cell development (GO:0046548)2.64989825
118myeloid dendritic cell activation (GO:0001773)2.64849261
119positive regulation of granulocyte differentiation (GO:0030854)2.64200937
120histone mRNA metabolic process (GO:0008334)2.63674755
121antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.63160868
122pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.62958224
123positive regulation of B cell differentiation (GO:0045579)2.62949664
124ncRNA 3-end processing (GO:0043628)2.62136410
125synaptic transmission, cholinergic (GO:0007271)2.61694153
126immunoglobulin mediated immune response (GO:0016064)2.60606712
127tryptophan metabolic process (GO:0006568)2.59300940
128response to protozoan (GO:0001562)2.58936978
129inositol phosphate catabolic process (GO:0071545)2.58549633
130positive regulation of isotype switching (GO:0045830)2.58374873
131regulation of necrotic cell death (GO:0010939)2.56373204
132phosphorylated carbohydrate dephosphorylation (GO:0046838)2.55839406
133inositol phosphate dephosphorylation (GO:0046855)2.55839406
134positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.55639828
135deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.55083288
136mature B cell differentiation (GO:0002335)2.55073062
137purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.54675233
138positive regulation of macrophage differentiation (GO:0045651)2.54085231
139rRNA catabolic process (GO:0016075)2.53936301
140aggressive behavior (GO:0002118)2.53616983
141protein polyglutamylation (GO:0018095)2.53068448
142deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.52667111
143C-terminal protein lipidation (GO:0006501)2.52366792
144RNA catabolic process (GO:0006401)2.52082640
145sulfate transmembrane transport (GO:1902358)2.51710105
146regulation of cilium movement (GO:0003352)2.51407437
147interferon-gamma production (GO:0032609)2.49401505
148deoxyribonucleotide catabolic process (GO:0009264)2.48684084
149Arp2/3 complex-mediated actin nucleation (GO:0034314)2.47474777
150intracellular protein transmembrane import (GO:0044743)2.47236158
151cilium morphogenesis (GO:0060271)2.46913169
152quinone biosynthetic process (GO:1901663)2.46030122
153respiratory chain complex IV assembly (GO:0008535)2.44735526
154brain morphogenesis (GO:0048854)2.44036688
155necrotic cell death (GO:0070265)2.42029180
156epithelial cilium movement (GO:0003351)2.41783890
157regulation of action potential (GO:0098900)2.41434502
158peptidyl-histidine modification (GO:0018202)2.41109295
159negative regulation of heart rate (GO:0010459)2.40574316
160response to peptidoglycan (GO:0032494)2.40232766
161necroptotic process (GO:0070266)2.39504478
162mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.39485266
163mitochondrial respiratory chain complex I assembly (GO:0032981)2.39485266
164NADH dehydrogenase complex assembly (GO:0010257)2.39485266
165purine-containing compound salvage (GO:0043101)2.39345345
166cerebral cortex radially oriented cell migration (GO:0021799)2.38829537
167regulation of B cell differentiation (GO:0045577)2.38044742
168protein complex biogenesis (GO:0070271)2.37777223
169fucose catabolic process (GO:0019317)2.37346925
170L-fucose metabolic process (GO:0042354)2.37346925
171L-fucose catabolic process (GO:0042355)2.37346925
172mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.37211517
173positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.37211517
174mast cell activation (GO:0045576)2.35375104
175positive regulation of alpha-beta T cell proliferation (GO:0046641)2.33931928
176lymphoid progenitor cell differentiation (GO:0002320)2.33811289
177interferon-gamma-mediated signaling pathway (GO:0060333)2.33070710
178regulation of alpha-beta T cell proliferation (GO:0046640)2.31026772
179negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.30114848
180negative regulation of erythrocyte differentiation (GO:0045647)2.29580138
181T cell lineage commitment (GO:0002360)2.27481955
182metallo-sulfur cluster assembly (GO:0031163)2.26544372
183iron-sulfur cluster assembly (GO:0016226)2.26544372
184neutrophil activation (GO:0042119)2.25507475
185regulation of respiratory burst (GO:0060263)2.24042336
186myeloid dendritic cell differentiation (GO:0043011)2.23515866
187purine deoxyribonucleotide catabolic process (GO:0009155)2.22109783

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.87999335
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.28051804
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.62491331
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.13085927
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.04781789
6SCL_19346495_ChIP-Seq_HPC-7_Human3.03276486
7SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.00513996
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.90627429
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.82660933
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.79599919
11ZNF274_21170338_ChIP-Seq_K562_Hela2.75365620
12FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.71189489
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.68911044
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.66570179
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50310673
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.44923836
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.44098484
18VDR_23849224_ChIP-Seq_CD4+_Human2.43433482
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.41020551
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.37956063
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.37170449
22VDR_22108803_ChIP-Seq_LS180_Human2.36015378
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.34713507
24* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.33211731
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.28363659
26HOXB4_20404135_ChIP-ChIP_EML_Mouse2.28080264
27STAT4_19710469_ChIP-ChIP_TH1__Mouse2.27237101
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.23659599
29ERG_20887958_ChIP-Seq_HPC-7_Mouse2.22292682
30EWS_26573619_Chip-Seq_HEK293_Human2.21619926
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.20850531
32SRF_21415370_ChIP-Seq_HL-1_Mouse2.17730775
33SPI1_23547873_ChIP-Seq_NB4_Human2.16800522
34NOTCH1_21737748_ChIP-Seq_TLL_Human2.15319327
35ETS1_20019798_ChIP-Seq_JURKAT_Human2.13209591
36FLI1_27457419_Chip-Seq_LIVER_Mouse2.13103243
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.11790299
38GBX2_23144817_ChIP-Seq_PC3_Human2.10128730
39SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.02335885
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.01691919
41EGR1_23403033_ChIP-Seq_LIVER_Mouse2.00580582
42* ELK1_19687146_ChIP-ChIP_HELA_Human1.98978846
43EZH2_22144423_ChIP-Seq_EOC_Human1.97886365
44TAF15_26573619_Chip-Seq_HEK293_Human1.97441981
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.93394417
46CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.88793346
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.87702502
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87671965
49* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85320638
50FUS_26573619_Chip-Seq_HEK293_Human1.84593482
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.82661750
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79059956
53STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.78650872
54IRF8_27001747_Chip-Seq_BMDM_Mouse1.78157842
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.77973604
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.77201335
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77142702
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77141980
59FOXP3_21729870_ChIP-Seq_TREG_Human1.75326763
60P300_19829295_ChIP-Seq_ESCs_Human1.75287512
61NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74968865
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.74597125
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74210143
64MYC_18358816_ChIP-ChIP_MESCs_Mouse1.69465470
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67268599
66GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.65072263
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63138049
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61081598
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.60504394
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54236686
71CREB1_15753290_ChIP-ChIP_HEK293T_Human1.53255637
72VDR_24763502_ChIP-Seq_THP-1_Human1.52484291
73MYB_26560356_Chip-Seq_TH2_Human1.52032852
74ER_23166858_ChIP-Seq_MCF-7_Human1.50479644
75VDR_21846776_ChIP-Seq_THP-1_Human1.49963642
76IRF1_19129219_ChIP-ChIP_H3396_Human1.49186531
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47962435
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47645098
79TP53_22573176_ChIP-Seq_HFKS_Human1.47528738
80XRN2_22483619_ChIP-Seq_HELA_Human1.45275756
81ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.44704082
82* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.44500990
83DCP1A_22483619_ChIP-Seq_HELA_Human1.44363016
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43864447
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40589531
86MYB_26560356_Chip-Seq_TH1_Human1.38528150
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36604720
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36018919
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.34693314
90PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32271353
91GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31995169
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.31648693
93MYC_19030024_ChIP-ChIP_MESCs_Mouse1.30815542
94GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29767153
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29685382
96CBP_20019798_ChIP-Seq_JUKART_Human1.29685382
97TTF2_22483619_ChIP-Seq_HELA_Human1.26318712
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24003426
99LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23504664
100RUNX1_22412390_ChIP-Seq_EML_Mouse1.23495042
101GABP_19822575_ChIP-Seq_HepG2_Human1.22988692
102CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22975945
103BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22663270
104YY1_21170310_ChIP-Seq_MESCs_Mouse1.22654208
105SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21850025
106NFE2_27457419_Chip-Seq_LIVER_Mouse1.21578609
107* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.20766052
108RNF2_27304074_Chip-Seq_NSC_Mouse1.20590818
109STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20489521
110ELK1_22589737_ChIP-Seq_MCF10A_Human1.20140688
111MAF_26560356_Chip-Seq_TH1_Human1.18376385
112IGF1R_20145208_ChIP-Seq_DFB_Human1.18374375
113GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18308558
114CIITA_25753668_ChIP-Seq_RAJI_Human1.17686877
115RUNX_20019798_ChIP-Seq_JUKART_Human1.17157575
116BCAT_22108803_ChIP-Seq_LS180_Human1.16998655
117NANOG_19829295_ChIP-Seq_ESCs_Human1.16894792
118SOX2_19829295_ChIP-Seq_ESCs_Human1.16894792
119CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15724809
120AR_20517297_ChIP-Seq_VCAP_Human1.13717487
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13377179
122SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11893874
123ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11748004
124RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11476044
125SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09524512
126* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05970783
127BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05848707
128KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05480329
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05172333
130FOXA1_25329375_ChIP-Seq_VCAP_Human1.04991532
131FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04991532
132AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04630226
133EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04157531
134SMAD4_21799915_ChIP-Seq_A2780_Human1.04156980
135* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04082872
136CRX_20693478_ChIP-Seq_RETINA_Mouse1.03509979
137TCF4_22108803_ChIP-Seq_LS180_Human1.02195188
138* P53_22387025_ChIP-Seq_ESCs_Mouse1.01630990
139FLI1_21867929_ChIP-Seq_TH2_Mouse1.01617633
140REST_21632747_ChIP-Seq_MESCs_Mouse1.01126610
141PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01068035
142THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00601679
143CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00262928
144PRDM14_20953172_ChIP-Seq_ESCs_Human0.99441816
145BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98952997
146CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98828943
147TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97366756
148MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97143144
149TFEB_21752829_ChIP-Seq_HELA_Human0.96993194
150AR_25329375_ChIP-Seq_VCAP_Human0.96970048
151MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96800578
152MYC_18940864_ChIP-ChIP_HL60_Human0.96770929
153PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96751801
154GATA3_26560356_Chip-Seq_TH2_Human0.96598861
155CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96220395
156POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95746337
157TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95746337
158FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95686132
159RXR_22158963_ChIP-Seq_LIVER_Mouse0.95609629
160SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.94955428
161PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94773058
162CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94162802
163CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93503809
164MAF_26560356_Chip-Seq_TH2_Human0.93320992
165EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93092116
166MYC_19829295_ChIP-Seq_ESCs_Human0.92753854
167FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92200354
168RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91843986
169FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91474041
170HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90096327
171NELFA_20434984_ChIP-Seq_ESCs_Mouse0.89587459
172FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89037175
173PU_27001747_Chip-Seq_BMDM_Mouse0.87217664

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.38143421
2MP0005671_abnormal_response_to3.46017447
3MP0000685_abnormal_immune_system3.35439293
4MP0009785_altered_susceptibility_to3.33769751
5MP0002396_abnormal_hematopoietic_system3.00932861
6MP0003787_abnormal_imprinting2.92977430
7MP0003724_increased_susceptibility_to2.86946295
8MP0006292_abnormal_olfactory_placode2.69207459
9MP0003436_decreased_susceptibility_to2.67773143
10MP0005025_abnormal_response_to2.66716276
11MP0005000_abnormal_immune_tolerance2.52572176
12MP0002148_abnormal_hypersensitivity_rea2.43078000
13MP0002723_abnormal_immune_serum2.39725659
14MP0001800_abnormal_humoral_immune2.36988665
15MP0009379_abnormal_foot_pigmentation2.36859673
16MP0002132_abnormal_respiratory_system2.35550890
17* MP0002452_abnormal_antigen_presenting2.28714001
18MP0002419_abnormal_innate_immunity2.21079838
19MP0002837_dystrophic_cardiac_calcinosis2.19297918
20MP0008877_abnormal_DNA_methylation2.15665154
21* MP0001819_abnormal_immune_cell2.15537519
22* MP0002420_abnormal_adaptive_immunity2.15398893
23MP0003880_abnormal_central_pattern2.15207357
24MP0003763_abnormal_thymus_physiology2.14718255
25MP0005174_abnormal_tail_pigmentation2.08018752
26* MP0001790_abnormal_immune_system2.05135316
27* MP0005387_immune_system_phenotype2.05135316
28MP0006276_abnormal_autonomic_nervous2.04502828
29MP0005551_abnormal_eye_electrophysiolog2.01610789
30MP0001984_abnormal_olfaction1.99322015
31MP0002398_abnormal_bone_marrow1.96609696
32MP0008260_abnormal_autophagy1.96269916
33* MP0000716_abnormal_immune_system1.95012946
34MP0003122_maternal_imprinting1.94668720
35MP0001968_abnormal_touch/_nociception1.94128452
36MP0006082_CNS_inflammation1.92655498
37MP0005464_abnormal_platelet_physiology1.87647044
38MP0009333_abnormal_splenocyte_physiolog1.86909128
39MP0006072_abnormal_retinal_apoptosis1.85862369
40MP0008789_abnormal_olfactory_epithelium1.82166272
41MP0004885_abnormal_endolymph1.78437902
42MP0010155_abnormal_intestine_physiology1.74878337
43MP0001529_abnormal_vocalization1.73920554
44MP0005075_abnormal_melanosome_morpholog1.73364252
45MP0000689_abnormal_spleen_morphology1.70633373
46MP0003121_genomic_imprinting1.69777680
47MP0002138_abnormal_hepatobiliary_system1.68027685
48MP0004145_abnormal_muscle_electrophysio1.66302737
49MP0003186_abnormal_redox_activity1.64929552
50MP0002736_abnormal_nociception_after1.64834622
51MP0003866_abnormal_defecation1.63435254
52MP0003656_abnormal_erythrocyte_physiolo1.63111875
53* MP0002429_abnormal_blood_cell1.62261247
54MP0000490_abnormal_crypts_of1.61503913
55MP0002722_abnormal_immune_system1.61296980
56MP0002139_abnormal_hepatobiliary_system1.59862018
57MP0005360_urolithiasis1.59526532
58MP0001845_abnormal_inflammatory_respons1.58628706
59MP0002405_respiratory_system_inflammati1.58585020
60MP0002272_abnormal_nervous_system1.54318661
61MP0001873_stomach_inflammation1.54207017
62MP0001853_heart_inflammation1.54019004
63MP0008469_abnormal_protein_level1.53990933
64MP0005253_abnormal_eye_physiology1.52115525
65MP0005646_abnormal_pituitary_gland1.49951086
66MP0004742_abnormal_vestibular_system1.49792749
67MP0009745_abnormal_behavioral_response1.49562926
68MP0005058_abnormal_lysosome_morphology1.49245721
69MP0002102_abnormal_ear_morphology1.48783869
70MP0010386_abnormal_urinary_bladder1.47455719
71MP0000569_abnormal_digit_pigmentation1.47380613
72MP0002735_abnormal_chemical_nociception1.45016318
73MP0003011_delayed_dark_adaptation1.40957489
74MP0005365_abnormal_bile_salt1.40763161
75MP0001970_abnormal_pain_threshold1.39747630
76MP0000631_abnormal_neuroendocrine_gland1.39254846
77MP0004808_abnormal_hematopoietic_stem1.36606162
78MP0002638_abnormal_pupillary_reflex1.36445632
79MP0002653_abnormal_ependyma_morphology1.34888999
80MP0005397_hematopoietic_system_phenotyp1.32453097
81MP0001545_abnormal_hematopoietic_system1.32453097
82MP0002166_altered_tumor_susceptibility1.31105923
83MP0002234_abnormal_pharynx_morphology1.30643596
84MP0009697_abnormal_copulation1.30326814
85MP0002095_abnormal_skin_pigmentation1.30176570
86MP0009046_muscle_twitch1.30115114
87MP0005085_abnormal_gallbladder_physiolo1.29374248
88MP0005499_abnormal_olfactory_system1.28408986
89MP0005394_taste/olfaction_phenotype1.28408986
90MP0001986_abnormal_taste_sensitivity1.26872973
91MP0009764_decreased_sensitivity_to1.24854534
92MP0003136_yellow_coat_color1.24660740
93MP0001486_abnormal_startle_reflex1.24449799
94MP0002557_abnormal_social/conspecific_i1.22924883
95* MP0008058_abnormal_DNA_repair1.22607610
96MP0000703_abnormal_thymus_morphology1.22370525
97MP0008872_abnormal_physiological_respon1.20134453
98MP0002938_white_spotting1.19173289
99MP0002572_abnormal_emotion/affect_behav1.18501337
100MP0003635_abnormal_synaptic_transmissio1.18320534
101MP0004043_abnormal_pH_regulation1.18265206
102MP0005389_reproductive_system_phenotype1.14237663
103MP0000465_gastrointestinal_hemorrhage1.14204395
104MP0008875_abnormal_xenobiotic_pharmacok1.13848648
105MP0002733_abnormal_thermal_nociception1.13169272
106MP0000516_abnormal_urinary_system1.12467869
107MP0005367_renal/urinary_system_phenotyp1.12467869
108MP0005386_behavior/neurological_phenoty1.12042993
109MP0004924_abnormal_behavior1.12042993
110MP0006036_abnormal_mitochondrial_physio1.11995752
111MP0002822_catalepsy1.11623276
112MP0000372_irregular_coat_pigmentation1.11473278
113MP0002160_abnormal_reproductive_system1.10681516
114MP0002928_abnormal_bile_duct1.09192059
115MP0001533_abnormal_skeleton_physiology1.08365486
116MP0001188_hyperpigmentation1.08227285
117MP0002006_tumorigenesis1.08186845
118MP0005310_abnormal_salivary_gland1.06366109
119MP0002933_joint_inflammation1.05020951
120MP0002876_abnormal_thyroid_physiology1.04475992
121MP0001764_abnormal_homeostasis1.03326305
122MP0003646_muscle_fatigue1.03097381
123MP0000778_abnormal_nervous_system1.02760590
124MP0003806_abnormal_nucleotide_metabolis1.01939902
125MP0005195_abnormal_posterior_eye1.00436875
126MP0000049_abnormal_middle_ear0.99807355
127MP0006035_abnormal_mitochondrial_morpho0.99549463
128MP0004947_skin_inflammation0.99467431
129MP0002163_abnormal_gland_morphology0.98676235
130MP0002067_abnormal_sensory_capabilities0.98440440
131MP0001919_abnormal_reproductive_system0.98436735
132MP0005084_abnormal_gallbladder_morpholo0.98104369
133MP0000015_abnormal_ear_pigmentation0.96304842
134MP0009763_increased_sensitivity_to0.94835327
135MP0003045_fibrosis0.94261505
136MP0002063_abnormal_learning/memory/cond0.91067279
137MP0000427_abnormal_hair_cycle0.91056022
138MP0004859_abnormal_synaptic_plasticity0.91021491
139MP0002734_abnormal_mechanical_nocicepti0.90372150
140MP0000858_altered_metastatic_potential0.85860342
141MP0002064_seizures0.85376645
142MP0005645_abnormal_hypothalamus_physiol0.84690171
143MP0004510_myositis0.84325588
144MP0002752_abnormal_somatic_nervous0.82785952
145MP0003252_abnormal_bile_duct0.82498001
146MP0000647_abnormal_sebaceous_gland0.81783910
147MP0003693_abnormal_embryo_hatching0.81649458
148MP0001905_abnormal_dopamine_level0.80083845
149MP0008007_abnormal_cellular_replicative0.79835881
150MP0005187_abnormal_penis_morphology0.79114706
151MP0001663_abnormal_digestive_system0.78688348
152MP0003195_calcinosis0.77206785
153MP0001963_abnormal_hearing_physiology0.77114704
154MP0004142_abnormal_muscle_tone0.76222507
155* MP0002019_abnormal_tumor_incidence0.75919387
156MP0003868_abnormal_feces_composition0.75294411
157MP0002184_abnormal_innervation0.74160821
158MP0009765_abnormal_xenobiotic_induced0.74125167
159* MP0000598_abnormal_liver_morphology0.72964197
160MP0001501_abnormal_sleep_pattern0.72010556
161MP0000609_abnormal_liver_physiology0.71774910
162MP0002229_neurodegeneration0.71717201
163MP0005319_abnormal_enzyme/_coenzyme0.71068745
164MP0005584_abnormal_enzyme/coenzyme_acti0.69824347
165MP0002998_abnormal_bone_remodeling0.69461966
166MP0005379_endocrine/exocrine_gland_phen0.68914136
167MP0002277_abnormal_respiratory_mucosa0.68723811
168MP0005636_abnormal_mineral_homeostasis0.68004103
169MP0000681_abnormal_thyroid_gland0.66561815
170MP0009840_abnormal_foam_cell0.65288665
171MP0004147_increased_porphyrin_level0.63543747
172MP0005332_abnormal_amino_acid0.63399055
173MP0003786_premature_aging0.62852054
174MP0000613_abnormal_salivary_gland0.61317913
175MP0008995_early_reproductive_senescence0.58491986

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)3.93067248
2Abnormality of cells of the erythroid lineage (HP:0012130)3.91011697
3Reticulocytopenia (HP:0001896)3.76713924
4Thrombocytosis (HP:0001894)3.74871296
5Elevated erythrocyte sedimentation rate (HP:0003565)3.73490948
6Abnormal number of erythroid precursors (HP:0012131)3.70159306
7Pancreatic cysts (HP:0001737)3.54020901
8Hypothermia (HP:0002045)3.51000606
9Pallor (HP:0000980)3.44220941
10Molar tooth sign on MRI (HP:0002419)3.43467367
11Abnormality of midbrain morphology (HP:0002418)3.43467367
12Abnormality of aromatic amino acid family metabolism (HP:0004338)3.38806662
13Myositis (HP:0100614)3.35202079
14Increased hepatocellular lipid droplets (HP:0006565)3.35148003
15Medial flaring of the eyebrow (HP:0010747)3.30992719
16Recurrent abscess formation (HP:0002722)3.27162478
17Recurrent bacterial skin infections (HP:0005406)3.19623485
18Pancreatic fibrosis (HP:0100732)3.18466451
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.18014536
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.18014536
21Lipid accumulation in hepatocytes (HP:0006561)3.11190748
22Abnormality of macrophages (HP:0004311)3.09896065
23Hepatocellular necrosis (HP:0001404)3.08787158
24Nephronophthisis (HP:0000090)3.07687474
25Exertional dyspnea (HP:0002875)3.04634356
26Macrocytic anemia (HP:0001972)3.04268581
27Eczematoid dermatitis (HP:0000976)3.00647430
28Renal Fanconi syndrome (HP:0001994)3.00137044
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.96049025
30Hepatic necrosis (HP:0002605)2.92867331
31Gait imbalance (HP:0002141)2.89468108
32Mitochondrial inheritance (HP:0001427)2.89029448
33Retinal dysplasia (HP:0007973)2.88544751
34Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.88404608
35Aplastic anemia (HP:0001915)2.87203989
36True hermaphroditism (HP:0010459)2.86412011
37IgM deficiency (HP:0002850)2.84091192
38Congenital primary aphakia (HP:0007707)2.83810692
39Optic neuritis (HP:0100653)2.83128464
40Retrobulbar optic neuritis (HP:0100654)2.83128464
41Cerebral edema (HP:0002181)2.82866725
42Reduced antithrombin III activity (HP:0001976)2.82568894
43Prolonged bleeding time (HP:0003010)2.80578461
44Nephrogenic diabetes insipidus (HP:0009806)2.78653986
45Vasculitis (HP:0002633)2.73738423
46B lymphocytopenia (HP:0010976)2.72999039
47Abnormality of B cell number (HP:0010975)2.72999039
48Abnormality of the heme biosynthetic pathway (HP:0010472)2.71565690
49Cerebellar dysplasia (HP:0007033)2.71057842
50Increased intramyocellular lipid droplets (HP:0012240)2.70663884
51Orchitis (HP:0100796)2.70151796
52Panhypogammaglobulinemia (HP:0003139)2.66618584
53Recurrent skin infections (HP:0001581)2.60855913
54Abnormality of the renal medulla (HP:0100957)2.58900167
55Encephalitis (HP:0002383)2.58585346
56Congenital stationary night blindness (HP:0007642)2.57565992
57Gastrointestinal stroma tumor (HP:0100723)2.54481824
58Type I transferrin isoform profile (HP:0003642)2.53279209
59Meningitis (HP:0001287)2.51875706
60Recurrent fungal infections (HP:0002841)2.50808845
61Methylmalonic acidemia (HP:0002912)2.50414337
62Epistaxis (HP:0000421)2.47482282
63Acute necrotizing encephalopathy (HP:0006965)2.46384539
64Abnormality of the renal cortex (HP:0011035)2.43805900
65Optic disc pallor (HP:0000543)2.43487408
66Lissencephaly (HP:0001339)2.41452401
67Hyperglycinemia (HP:0002154)2.38707876
68Renal cortical cysts (HP:0000803)2.37405868
69Increased muscle lipid content (HP:0009058)2.36646298
70Chronic otitis media (HP:0000389)2.36622804
71Abnormality of the prostate (HP:0008775)2.36246594
72Aplasia/Hypoplasia of the sacrum (HP:0008517)2.34972071
73Acute encephalopathy (HP:0006846)2.34290111
74Petechiae (HP:0000967)2.33399611
75Colon cancer (HP:0003003)2.33263376
763-Methylglutaconic aciduria (HP:0003535)2.31657528
77Generalized aminoaciduria (HP:0002909)2.31642437
78Gonadotropin excess (HP:0000837)2.31474168
79Neutropenia (HP:0001875)2.30474748
80Increased CSF lactate (HP:0002490)2.29112321
81Gingival bleeding (HP:0000225)2.28551089
82Absent rod-and cone-mediated responses on ERG (HP:0007688)2.28237543
83Vacuolated lymphocytes (HP:0001922)2.27596952
84Abnormal mitochondria in muscle tissue (HP:0008316)2.27323793
85Recurrent gram-negative bacterial infections (HP:0005420)2.26616855
86Prolonged partial thromboplastin time (HP:0003645)2.25412342
87Obstructive lung disease (HP:0006536)2.25136465
88Chronic obstructive pulmonary disease (HP:0006510)2.25136465
89Recurrent viral infections (HP:0004429)2.24179801
90IgG deficiency (HP:0004315)2.23655015
91Abnormal rod and cone electroretinograms (HP:0008323)2.22444500
92Muscle fiber atrophy (HP:0100295)2.22141515
93Mediastinal lymphadenopathy (HP:0100721)2.20938539
94Chronic hepatic failure (HP:0100626)2.20631860
95Methylmalonic aciduria (HP:0012120)2.19759633
96Attenuation of retinal blood vessels (HP:0007843)2.18800963
97Granulocytopenia (HP:0001913)2.15762476
98Abnormal hemoglobin (HP:0011902)2.14568290
99Respiratory failure (HP:0002878)2.13889780
100Microcytic anemia (HP:0001935)2.13754877
101Lactic acidosis (HP:0003128)2.13704538
102Lymphopenia (HP:0001888)2.12369686
103Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.08632645
104Abnormal protein N-linked glycosylation (HP:0012347)2.08632645
105Abnormal protein glycosylation (HP:0012346)2.08632645
106Abnormal glycosylation (HP:0012345)2.08632645
107Recurrent pneumonia (HP:0006532)2.08277359
108Periodontitis (HP:0000704)2.07931736
109Abnormal delayed hypersensitivity skin test (HP:0002963)2.07758645
110Hypoplasia of the thymus (HP:0000778)2.07553095
111Lethargy (HP:0001254)2.07393583
112Thyroid-stimulating hormone excess (HP:0002925)2.07056057
113Purpura (HP:0000979)2.06914268
114Recurrent cutaneous fungal infections (HP:0011370)2.06359689
115Chronic mucocutaneous candidiasis (HP:0002728)2.06359689
116Abnormality of methionine metabolism (HP:0010901)2.05406418
117Inflammation of the large intestine (HP:0002037)2.04336012
118Abolished electroretinogram (ERG) (HP:0000550)2.00579504
119Thyroiditis (HP:0100646)2.00366472
120Recurrent bronchitis (HP:0002837)1.99816919
121Calf muscle hypertrophy (HP:0008981)1.99743083
122Abnormality of cells of the lymphoid lineage (HP:0012140)1.99652133
123Cystic liver disease (HP:0006706)1.97620313
124Severe combined immunodeficiency (HP:0004430)1.96263039
125Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.96165123
126CNS demyelination (HP:0007305)1.95633640
127Increased serum lactate (HP:0002151)1.94556196
128Exercise intolerance (HP:0003546)1.94463368
129Gastrointestinal inflammation (HP:0004386)1.94395070
130Muscle hypertrophy of the lower extremities (HP:0008968)1.94140422
131Hypergammaglobulinemia (HP:0010702)1.92540302
132Abnormality of alanine metabolism (HP:0010916)1.92127501
133Hyperalaninemia (HP:0003348)1.92127501
134Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92127501
135Abnormality of T cell physiology (HP:0011840)1.91917984
136Postaxial foot polydactyly (HP:0001830)1.91258982
137Recurrent lower respiratory tract infections (HP:0002783)1.90987851
138Progressive microcephaly (HP:0000253)1.90907025
139Eosinophilia (HP:0001880)1.90885343
140Congenital, generalized hypertrichosis (HP:0004540)1.90315258
141Hypoproteinemia (HP:0003075)1.90081422
142Type 2 muscle fiber atrophy (HP:0003554)1.89902770
143Leukodystrophy (HP:0002415)1.88816837
144Genital tract atresia (HP:0001827)1.88416020
145Increased IgM level (HP:0003496)1.87694394
146Leukocytosis (HP:0001974)1.86976826
147Progressive macrocephaly (HP:0004481)1.86162976
148Poor coordination (HP:0002370)1.85129706
149Hypoplasia of the pons (HP:0012110)1.84765167
150Severe muscular hypotonia (HP:0006829)1.84749019
151Vaginal atresia (HP:0000148)1.81666276
152Bile duct proliferation (HP:0001408)1.80386017
153Abnormal biliary tract physiology (HP:0012439)1.80386017
154Pancytopenia (HP:0001876)1.80293073
155Sclerocornea (HP:0000647)1.79616603
156Constricted visual fields (HP:0001133)1.77873516
157Dyskinesia (HP:0100660)1.76691008
158Postaxial hand polydactyly (HP:0001162)1.75919816
159* Abnormality of DNA repair (HP:0003254)1.75537457
160Metaphyseal dysplasia (HP:0100255)1.71144800
161Aplasia/Hypoplasia of the tongue (HP:0010295)1.71080896
162Congenital hepatic fibrosis (HP:0002612)1.69341237
163Abnormality of the pons (HP:0007361)1.64408249
164Pachygyria (HP:0001302)1.63406356
165Abnormality of the metopic suture (HP:0005556)1.63103372
166Abnormality of renal resorption (HP:0011038)1.62045393
167Abnormality of dicarboxylic acid metabolism (HP:0010995)1.61382900
168Dicarboxylic aciduria (HP:0003215)1.61382900

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.11243716
2NME23.95220986
3PIM22.88897175
4TXK2.78648291
5FRK2.68785172
6MAP4K12.58732424
7BCR2.54713585
8KIT2.54331775
9RIPK42.46133065
10IRAK42.45823520
11EIF2AK12.30032902
12JAK32.28628711
13MAP3K42.23190078
14NUAK12.22855446
15TRIM282.21381819
16WNK32.09906140
17TEC2.08993001
18TAOK32.05517910
19TBK11.98443195
20MAPK131.98069019
21IKBKE1.94840454
22FLT31.91024565
23TLK11.87932829
24ERBB31.85982107
25MAP2K31.80549295
26ZAK1.78560543
27IKBKB1.74497720
28IRAK31.74157200
29PINK11.72318185
30BMPR1B1.66429864
31MUSK1.65116650
32STK161.64325896
33BLK1.63073787
34TNIK1.62130448
35CAMKK21.60958295
36ZAP701.56927353
37MAP3K141.52520292
38CSNK1G21.48307571
39CDK191.45677536
40CSNK1A1L1.43462196
41BTK1.42515019
42EIF2AK31.36731076
43CCNB11.33938125
44ACVR1B1.32581380
45SYK1.31815592
46MARK11.30914038
47CSF1R1.27747430
48GRK11.25407809
49DYRK31.24101501
50WNK41.23606882
51SRPK11.21049603
52MAP3K121.19092098
53VRK11.18970039
54TYK21.17951672
55MAP2K61.15804967
56VRK21.14057535
57PIM11.14042800
58NLK1.07988300
59LYN1.06884795
60RPS6KA41.05714245
61KDR1.01287443
62EIF2AK21.00672557
63PIK3CG0.99030010
64INSRR0.97496092
65YES10.91285289
66OBSCN0.90660614
67TGFBR20.89894464
68BUB10.89539428
69JAK10.88958311
70LCK0.88659519
71OXSR10.88630001
72TGFBR10.87063319
73CHUK0.85461899
74MAP2K40.80884394
75IRAK10.80354527
76PRKCE0.80245492
77MAP2K70.78608601
78RPS6KA50.77092768
79MKNK10.76110375
80PHKG10.75218893
81PHKG20.75218893
82EPHB10.74978731
83MAP3K110.73837339
84ILK0.73786455
85MINK10.73770905
86NME10.73425194
87ABL20.71629284
88SCYL20.66790004
89ADRBK20.66749406
90NTRK20.65777313
91HIPK20.65199240
92UHMK10.63902999
93ARAF0.63749721
94NEK90.63748276
95ERN10.63549295
96BMPR20.61992969
97PAK30.61685767
98LIMK10.61090668
99PIK3CA0.60339759
100PBK0.59949574
101TNK20.58876374
102PLK40.58654051
103DYRK20.57563442
104MKNK20.57161620
105BRAF0.56839774
106CDK80.56490810
107TIE10.56062276
108CSNK1G30.55853756
109LRRK20.55394139
110SIK10.54704285
111PDK20.54340247
112IRAK20.53625823
113DAPK20.53210005
114CASK0.53146970
115CAMK2A0.53111983
116BCKDK0.52482195
117GRK60.52254304
118CSNK1A10.51878711
119PRKCG0.51233026
120PLK20.50880964
121DYRK1B0.50340551
122FGFR40.50099527
123PRKACA0.49476039
124TESK20.48873461
125ITK0.48702591
126GRK50.48632316
127GRK70.48211831
128ADRBK10.48163742
129RIPK10.47988354
130PRKCQ0.47428393
131STK390.46437138
132PRKCD0.45597829
133SIK30.42613669
134DAPK30.42106064
135FES0.41954715
136MOS0.40954079
137TAF10.40102658
138CAMK10.39787925
139EPHA30.39549418
140MST40.39310407
141PRKD20.39302598
142MAP3K50.39127052
143CSNK1G10.38973543
144BRSK20.37728119
145RPS6KB20.37013288
146CSNK2A20.36821097
147MAPKAPK50.36773001
148CAMK40.35391721
149CSNK1D0.35019585
150CDK30.31729112
151PRKG10.31371641
152PRKACB0.30662075
153DAPK10.30654207
154CAMK2D0.30098530

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.21092984
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.00109482
3Proteasome_Homo sapiens_hsa030502.60805474
4Protein export_Homo sapiens_hsa030602.45924663
5Primary immunodeficiency_Homo sapiens_hsa053402.32797889
6Folate biosynthesis_Homo sapiens_hsa007902.25744151
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.16823984
8Type I diabetes mellitus_Homo sapiens_hsa049402.06792825
9RNA polymerase_Homo sapiens_hsa030202.05900870
10Phototransduction_Homo sapiens_hsa047442.05404933
11Sulfur relay system_Homo sapiens_hsa041221.94601325
12Butanoate metabolism_Homo sapiens_hsa006501.92043065
13Parkinsons disease_Homo sapiens_hsa050121.86860181
14Oxidative phosphorylation_Homo sapiens_hsa001901.85907674
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.80944857
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.79853600
17Leishmaniasis_Homo sapiens_hsa051401.79790233
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.79392301
19Cardiac muscle contraction_Homo sapiens_hsa042601.62497228
20Homologous recombination_Homo sapiens_hsa034401.61338824
21Non-homologous end-joining_Homo sapiens_hsa034501.59380478
22Measles_Homo sapiens_hsa051621.55911018
23Allograft rejection_Homo sapiens_hsa053301.52078991
24Nicotine addiction_Homo sapiens_hsa050331.50378577
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.47793432
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.44518048
27Pyrimidine metabolism_Homo sapiens_hsa002401.44272991
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.43154396
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39149783
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.37464699
31Propanoate metabolism_Homo sapiens_hsa006401.35592015
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.33366820
33Histidine metabolism_Homo sapiens_hsa003401.29773273
34Herpes simplex infection_Homo sapiens_hsa051681.28670140
35Graft-versus-host disease_Homo sapiens_hsa053321.27786405
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.27251673
37Other glycan degradation_Homo sapiens_hsa005111.22830118
38Alzheimers disease_Homo sapiens_hsa050101.22368675
39Tryptophan metabolism_Homo sapiens_hsa003801.21196700
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18208853
41Collecting duct acid secretion_Homo sapiens_hsa049661.17442859
42Hematopoietic cell lineage_Homo sapiens_hsa046401.16298779
43DNA replication_Homo sapiens_hsa030301.14725586
44Huntingtons disease_Homo sapiens_hsa050161.13640425
45Legionellosis_Homo sapiens_hsa051341.13367740
46Caffeine metabolism_Homo sapiens_hsa002321.12609827
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12278945
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10310435
49Staphylococcus aureus infection_Homo sapiens_hsa051501.07824129
50Malaria_Homo sapiens_hsa051441.07180397
51Basal transcription factors_Homo sapiens_hsa030221.05445709
52Antigen processing and presentation_Homo sapiens_hsa046121.04319300
53Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01290867
54Jak-STAT signaling pathway_Homo sapiens_hsa046300.99948062
55Linoleic acid metabolism_Homo sapiens_hsa005910.99432587
56Mismatch repair_Homo sapiens_hsa034300.97641048
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96942882
58Regulation of autophagy_Homo sapiens_hsa041400.96671672
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96658140
60Selenocompound metabolism_Homo sapiens_hsa004500.96562214
61GABAergic synapse_Homo sapiens_hsa047270.95683140
62Pertussis_Homo sapiens_hsa051330.94700012
63Spliceosome_Homo sapiens_hsa030400.94260783
64Autoimmune thyroid disease_Homo sapiens_hsa053200.94114692
65Peroxisome_Homo sapiens_hsa041460.93753000
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.93674214
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93285412
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93133738
69Osteoclast differentiation_Homo sapiens_hsa043800.91732613
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88288896
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87510993
72Influenza A_Homo sapiens_hsa051640.86693117
73Systemic lupus erythematosus_Homo sapiens_hsa053220.85628909
74Olfactory transduction_Homo sapiens_hsa047400.84837228
75Sulfur metabolism_Homo sapiens_hsa009200.84824413
76B cell receptor signaling pathway_Homo sapiens_hsa046620.84283881
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.84074124
78Shigellosis_Homo sapiens_hsa051310.82833962
79Nitrogen metabolism_Homo sapiens_hsa009100.80379118
80Apoptosis_Homo sapiens_hsa042100.80224469
81Morphine addiction_Homo sapiens_hsa050320.79952240
82* Nucleotide excision repair_Homo sapiens_hsa034200.79908011
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79624887
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78671373
85Base excision repair_Homo sapiens_hsa034100.77474429
86Tuberculosis_Homo sapiens_hsa051520.76189750
87Steroid biosynthesis_Homo sapiens_hsa001000.75636208
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75324739
89Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75163015
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74549946
91Fanconi anemia pathway_Homo sapiens_hsa034600.73098166
92Taste transduction_Homo sapiens_hsa047420.71999578
93Chemical carcinogenesis_Homo sapiens_hsa052040.71602739
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70205055
95Fatty acid elongation_Homo sapiens_hsa000620.68228170
96Circadian entrainment_Homo sapiens_hsa047130.67955182
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67720268
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67496041
99Rheumatoid arthritis_Homo sapiens_hsa053230.67417609
100p53 signaling pathway_Homo sapiens_hsa041150.67285958
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66833795
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66461536
103RNA transport_Homo sapiens_hsa030130.66105198
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63509928
105beta-Alanine metabolism_Homo sapiens_hsa004100.62132937
106Complement and coagulation cascades_Homo sapiens_hsa046100.62131075
107Viral myocarditis_Homo sapiens_hsa054160.61977434
108Purine metabolism_Homo sapiens_hsa002300.61384978
109Toxoplasmosis_Homo sapiens_hsa051450.61018240
110RNA degradation_Homo sapiens_hsa030180.60856553
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60164058
112Arachidonic acid metabolism_Homo sapiens_hsa005900.59994009
113Synaptic vesicle cycle_Homo sapiens_hsa047210.59736756
114Epstein-Barr virus infection_Homo sapiens_hsa051690.59270858
115Salmonella infection_Homo sapiens_hsa051320.59143934
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.58613667
117Circadian rhythm_Homo sapiens_hsa047100.58033795
118Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57950595
119Phenylalanine metabolism_Homo sapiens_hsa003600.57663975
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56314115
121Ether lipid metabolism_Homo sapiens_hsa005650.55747585
122Retinol metabolism_Homo sapiens_hsa008300.54915846
123Hepatitis B_Homo sapiens_hsa051610.54352234
124TNF signaling pathway_Homo sapiens_hsa046680.54308503
125Dopaminergic synapse_Homo sapiens_hsa047280.53801241
126Acute myeloid leukemia_Homo sapiens_hsa052210.53724775
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.53036828
128Asthma_Homo sapiens_hsa053100.51817539
129Metabolic pathways_Homo sapiens_hsa011000.50760282
130Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50266884
131Glutamatergic synapse_Homo sapiens_hsa047240.47445901
132Pentose phosphate pathway_Homo sapiens_hsa000300.46907321
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46678863
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46024397
1352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43414115
136Serotonergic synapse_Homo sapiens_hsa047260.41416463
137Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40798111
138Cocaine addiction_Homo sapiens_hsa050300.38994197
139Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34458291
140Amphetamine addiction_Homo sapiens_hsa050310.31763978
141Glutathione metabolism_Homo sapiens_hsa004800.28796916
142Salivary secretion_Homo sapiens_hsa049700.28036666

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