XKRX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is related to a component of the XK/Kell complex of the Kell blood group system. The encoded protein includes several transmembrane domains, is known to be exposed to the cell surface, and may function as a membrane transporter. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organismal water homeostasis (GO:0050891)8.42632533
2keratinocyte differentiation (GO:0030216)8.03713584
3positive regulation of cellular amide metabolic process (GO:0034250)7.76390356
4water homeostasis (GO:0030104)6.96743799
5epidermal cell differentiation (GO:0009913)6.89792412
6keratinocyte proliferation (GO:0043616)6.40465619
7positive regulation of humoral immune response (GO:0002922)6.36046933
8phospholipid efflux (GO:0033700)6.28597515
9regulation of transforming growth factor beta1 production (GO:0032908)6.21403360
10bundle of His cell to Purkinje myocyte communication (GO:0086069)5.93527243
11epidermis development (GO:0008544)5.63511477
12peptide cross-linking (GO:0018149)5.56672767
13skin morphogenesis (GO:0043589)5.32686969
14surfactant homeostasis (GO:0043129)5.30671763
15lipoxygenase pathway (GO:0019372)5.22598540
16regulation of memory T cell differentiation (GO:0043380)4.90472673
17negative regulation of granulocyte differentiation (GO:0030853)4.80906548
18chemical homeostasis within a tissue (GO:0048875)4.75281627
19response to methylmercury (GO:0051597)4.73979962
20defense response to Gram-negative bacterium (GO:0050829)4.54080751
21germinal center formation (GO:0002467)4.51745845
22cell morphogenesis involved in neuron differentiation (GO:0048667)4.45852887
23G-protein coupled receptor internalization (GO:0002031)4.39370407
24positive regulation of glomerulus development (GO:0090193)4.29731651
25positive regulation of cholesterol efflux (GO:0010875)4.22710545
26regulation of cell proliferation involved in kidney development (GO:1901722)4.17588467
27linoleic acid metabolic process (GO:0043651)4.12511243
28regulation of cellular amide metabolic process (GO:0034248)4.07620277
29positive regulation of p38MAPK cascade (GO:1900745)3.99900783
30positive regulation of protein dephosphorylation (GO:0035307)3.91926157
31antimicrobial humoral response (GO:0019730)3.87869649
32regulation of germinal center formation (GO:0002634)3.86960104
33ectoderm development (GO:0007398)3.80242252
34phosphatidylserine acyl-chain remodeling (GO:0036150)3.77948909
35intermediate filament organization (GO:0045109)3.75835970
36regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.74065568
37positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.74065568
38response to folic acid (GO:0051593)3.72236848
39gap junction assembly (GO:0016264)3.71212904
40lymphoid progenitor cell differentiation (GO:0002320)3.70572931
41positive regulation of sterol transport (GO:0032373)3.63271980
42positive regulation of cholesterol transport (GO:0032376)3.63271980
43negative regulation of interferon-gamma production (GO:0032689)3.62838471
44negative regulation of osteoblast proliferation (GO:0033689)3.59020875
45intermediate filament cytoskeleton organization (GO:0045104)3.53800880
46establishment of skin barrier (GO:0061436)3.52744868
47DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.45341704
48branching involved in labyrinthine layer morphogenesis (GO:0060670)3.41226770
49defense response to fungus (GO:0050832)3.40695206
50phosphatidylinositol acyl-chain remodeling (GO:0036149)3.37826585
51desmosome organization (GO:0002934)3.37549714
52intermediate filament-based process (GO:0045103)3.37455088
53positive regulation of epidermis development (GO:0045684)3.32792464
54phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.32681754
55negative regulation of interleukin-17 production (GO:0032700)3.31075557
56positive regulation of transforming growth factor beta production (GO:0071636)3.30319371
57positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.29307732
58ceramide biosynthetic process (GO:0046513)3.26351517
59righting reflex (GO:0060013)3.25652609
60positive regulation of cellular amine metabolic process (GO:0033240)3.24820860
61regulation of natural killer cell differentiation (GO:0032823)3.21776065
62polarized epithelial cell differentiation (GO:0030859)3.21574909
63phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.21144747
64import into cell (GO:0098657)3.20898059
65axon ensheathment in central nervous system (GO:0032291)3.16616660
66central nervous system myelination (GO:0022010)3.16616660
67sphingosine metabolic process (GO:0006670)3.15670412
68hemidesmosome assembly (GO:0031581)3.14170150
69fatty acid elongation (GO:0030497)3.13922913
70positive regulation of keratinocyte differentiation (GO:0045618)3.11522931
71positive regulation of epidermal cell differentiation (GO:0045606)3.09962935
72regulation of timing of cell differentiation (GO:0048505)3.09213218
73sequestering of extracellular ligand from receptor (GO:0035581)3.09200934
74positive regulation of T-helper 1 type immune response (GO:0002827)3.07940574
75histone H3-K36 demethylation (GO:0070544)3.06983894
76regulation of DNA damage checkpoint (GO:2000001)3.06192960
77regulation of p38MAPK cascade (GO:1900744)3.04516820
78nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.02949992
79regulation of water loss via skin (GO:0033561)2.96401891
80regulation of keratinocyte differentiation (GO:0045616)2.96206346
81phosphatidylcholine acyl-chain remodeling (GO:0036151)2.96201637
82intestinal epithelial cell development (GO:0060576)2.95536641
83positive regulation of response to biotic stimulus (GO:0002833)2.95031975
84regulation of transforming growth factor beta production (GO:0071634)2.93610549
85sphingoid metabolic process (GO:0046519)2.93038298
86negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.92697538
87negative regulation of T-helper cell differentiation (GO:0045623)2.92697538
88regulation of platelet aggregation (GO:0090330)2.91178340
89regulation of phospholipase A2 activity (GO:0032429)2.90775966
90long-chain fatty acid biosynthetic process (GO:0042759)2.89749936
91molting cycle (GO:0042303)2.87677636
92hair cycle (GO:0042633)2.87677636
93dendritic cell migration (GO:0036336)2.87591936
94DNA damage response, signal transduction resulting in transcription (GO:0042772)2.86442750
95protein palmitoylation (GO:0018345)2.86166814
96RNA destabilization (GO:0050779)2.85875166
97detection of chemical stimulus involved in sensory perception (GO:0050907)2.84911370
98regulation of T-helper 2 cell differentiation (GO:0045628)2.84567424
99superoxide anion generation (GO:0042554)2.83817077
100negative regulation of keratinocyte proliferation (GO:0010839)2.82786550
101regulation of cholesterol homeostasis (GO:2000188)2.81332738
102DNA integration (GO:0015074)2.80694307
103post-embryonic morphogenesis (GO:0009886)2.79990172
104antibacterial humoral response (GO:0019731)2.79320106
105cranial nerve morphogenesis (GO:0021602)2.78692217
106glycerophospholipid catabolic process (GO:0046475)2.76030015
107regulation of somitogenesis (GO:0014807)2.75997208
108keratinization (GO:0031424)2.75728794
109bone remodeling (GO:0046849)2.74649098
110progesterone metabolic process (GO:0042448)2.73290116
111regulation of hair cycle (GO:0042634)2.71280802
112extracellular matrix assembly (GO:0085029)2.70743601
113keratinocyte development (GO:0003334)2.70591131
114regulation of glomerulus development (GO:0090192)2.70274243
115positive regulation of interleukin-8 secretion (GO:2000484)2.70123494
116regulation of MHC class I biosynthetic process (GO:0045343)2.69993880
117negative regulation of homotypic cell-cell adhesion (GO:0034111)2.69544939
118diol metabolic process (GO:0034311)2.69522968
119regulation of cholesterol efflux (GO:0010874)2.69413267
120G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.69178486
121androgen biosynthetic process (GO:0006702)2.68702445
122regulation of development, heterochronic (GO:0040034)2.67402684
123cerebral cortex radially oriented cell migration (GO:0021799)2.66781703
124histone H2B ubiquitination (GO:0033523)2.66578541
125regulation of T-helper 1 type immune response (GO:0002825)2.64501808
126negative regulation of Rho protein signal transduction (GO:0035024)2.64426721
127regulation of chemokine secretion (GO:0090196)2.64416428
128trophectodermal cell differentiation (GO:0001829)2.64079355
129female gonad development (GO:0008585)2.63589490
130establishment of integrated proviral latency (GO:0075713)2.63539533
131cell proliferation in forebrain (GO:0021846)2.62704769
132activation of MAPKKK activity (GO:0000185)2.62613001
133detection of external biotic stimulus (GO:0098581)2.62532365
134glucocorticoid biosynthetic process (GO:0006704)2.62263415
135mesonephros development (GO:0001823)2.61259971
136regulation of chemokine-mediated signaling pathway (GO:0070099)2.59892536
137limb bud formation (GO:0060174)2.59394188
138erythrocyte development (GO:0048821)2.57919171
139head development (GO:0060322)2.57877887
140centrosome duplication (GO:0051298)2.57023025
141epithelium development (GO:0060429)2.55972899
142hypotonic response (GO:0006971)2.55152004
143negative regulation of B cell mediated immunity (GO:0002713)2.52725540
144negative regulation of immunoglobulin mediated immune response (GO:0002890)2.52725540
145regulation of ruffle assembly (GO:1900027)2.52607055
146regulation of epidermis development (GO:0045682)2.52540340
147modulation by virus of host process (GO:0019054)2.51899351
148regulation of interleukin-5 production (GO:0032674)2.51532547
149establishment of planar polarity (GO:0001736)2.51441997
150establishment of tissue polarity (GO:0007164)2.51441997
151hyaluronan catabolic process (GO:0030214)2.50794778
152response to X-ray (GO:0010165)2.50193341
153detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.50138926
154bone trabecula formation (GO:0060346)2.49727576
155regulation of granulocyte differentiation (GO:0030852)2.49524998
156regulation of mRNA 3-end processing (GO:0031440)2.47952304
157regulation of protein dephosphorylation (GO:0035304)2.47796621
158superoxide metabolic process (GO:0006801)2.47662128
159short-term memory (GO:0007614)2.46164090
160termination of G-protein coupled receptor signaling pathway (GO:0038032)2.46040447
161negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.45764641
162epithelial cell-cell adhesion (GO:0090136)2.44460707
163protein heterotetramerization (GO:0051290)2.43914268
164regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.43687113
165epithelial cell differentiation involved in prostate gland development (GO:0060742)2.42356644
166left/right axis specification (GO:0070986)2.41682297
167early endosome to late endosome transport (GO:0045022)2.41024077
168regulation of DNA endoreduplication (GO:0032875)2.40799009
169facial nerve structural organization (GO:0021612)2.40239007
170regulation of interleukin-8 secretion (GO:2000482)2.39388746
171detection of other organism (GO:0098543)2.39325277
172positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.37497434
173genitalia morphogenesis (GO:0035112)2.37186540
174negative regulation of leukocyte chemotaxis (GO:0002689)2.36941664
175phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.36299113
176phospholipid scrambling (GO:0017121)2.36176562
177detection of bacterium (GO:0016045)2.35705868
178interferon-gamma production (GO:0032609)2.35599096
179regulation of protein localization to cell surface (GO:2000008)2.34945386
180cell fate commitment involved in formation of primary germ layer (GO:0060795)2.34747627
181sphingomyelin metabolic process (GO:0006684)2.32979537
182toxin transport (GO:1901998)2.32714754
183reflex (GO:0060004)2.32642743
184cellular response to lithium ion (GO:0071285)2.31947192
185phosphatidylserine metabolic process (GO:0006658)2.31175252
186regulation of neuron projection regeneration (GO:0070570)2.30695288

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1P63_26484246_Chip-Seq_KERATINOCYTES_Human3.81209980
2GBX2_23144817_ChIP-Seq_PC3_Human3.68326965
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.51538905
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.18367903
5SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.95464383
6SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.95464383
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.87665162
8FOXO3_23340844_ChIP-Seq_DLD1_Human2.82832204
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.80223437
10EZH2_22144423_ChIP-Seq_EOC_Human2.67734042
11PCGF2_27294783_Chip-Seq_NPCs_Mouse2.58384342
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.50787592
13SUZ12_27294783_Chip-Seq_NPCs_Mouse2.50694012
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.49338472
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.47651371
16ESR1_20079471_ChIP-ChIP_T-47D_Human2.33792221
17NFE2_27457419_Chip-Seq_LIVER_Mouse2.33697618
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32998248
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.30204026
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.28857122
21JARID2_20064375_ChIP-Seq_MESCs_Mouse2.22553218
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15585525
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.14676157
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.13367259
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.09370366
26TP63_23658742_ChIP-Seq_EP156T_Human2.00515288
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.97997315
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.95985328
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.90340946
30EZH2_27294783_Chip-Seq_NPCs_Mouse1.89628578
31KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.89484575
32RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.87643866
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.81976204
34DROSHA_22980978_ChIP-Seq_HELA_Human1.81403020
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.79156583
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.78407144
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.77922337
38FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.76573174
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.76144944
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.75755707
41SOX2_27498859_Chip-Seq_STOMACH_Mouse1.73552890
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.71536338
43AR_21572438_ChIP-Seq_LNCaP_Human1.70343821
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70174290
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.69453902
46TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.68162173
47FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.67767938
48SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.65636821
49EZH2_18974828_ChIP-Seq_MESCs_Mouse1.63084015
50RNF2_18974828_ChIP-Seq_MESCs_Mouse1.63084015
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.62687329
52SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.62342015
53EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.60521723
54SOX2_20726797_ChIP-Seq_SW620_Human1.58744794
55RUNX1_27514584_Chip-Seq_MCF-7_Human1.58491872
56GATA6_25053715_ChIP-Seq_YYC3_Human1.57970013
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57664111
58ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.57095095
59RACK7_27058665_Chip-Seq_MCF-7_Human1.57051662
60GATA3_24758297_ChIP-Seq_MCF-7_Human1.55019584
61ATF3_27146783_Chip-Seq_COLON_Human1.54468498
62* TP63_22573176_ChIP-Seq_HFKS_Human1.53763640
63SUZ12_18555785_Chip-Seq_ESCs_Mouse1.53102312
64SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52944202
65RXR_22108803_ChIP-Seq_LS180_Human1.51621997
66FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.51272829
67P53_22387025_ChIP-Seq_ESCs_Mouse1.50919133
68RARG_19884340_ChIP-ChIP_MEFs_Mouse1.49442883
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48943715
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.48248036
71JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47164239
72ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46721250
73STAT3_18555785_Chip-Seq_ESCs_Mouse1.46721217
74P300_18555785_Chip-Seq_ESCs_Mouse1.45892802
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43911757
76CMYC_18555785_Chip-Seq_ESCs_Mouse1.43856308
77EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.43823313
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43539467
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.42999421
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41291654
81GATA4_25053715_ChIP-Seq_YYC3_Human1.41169819
82SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40329019
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39783264
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36624949
85NMYC_18555785_Chip-Seq_ESCs_Mouse1.36288499
86TP53_18474530_ChIP-ChIP_U2OS_Human1.35838909
87RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35501462
88RUNX1_27457419_Chip-Seq_LIVER_Mouse1.34810277
89CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34777834
90IGF1R_20145208_ChIP-Seq_DFB_Human1.33795868
91CLOCK_20551151_ChIP-Seq_293T_Human1.30259365
92OCT4_18555785_Chip-Seq_ESCs_Mouse1.30195440
93ESRRB_18555785_Chip-Seq_ESCs_Mouse1.29983661
94SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.29388657
95OCT4_21477851_ChIP-Seq_ESCs_Mouse1.29142316
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.28949812
97NOTCH1_21737748_ChIP-Seq_TLL_Human1.28525989
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.27240208
99PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26800004
100CBX2_27304074_Chip-Seq_ESCs_Mouse1.25878892
101TP63_19390658_ChIP-ChIP_HaCaT_Human1.25411662
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24450299
103MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23487485
104SOX2_18555785_Chip-Seq_ESCs_Mouse1.22508782
105PU1_27457419_Chip-Seq_LIVER_Mouse1.21286612
106FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21267707
107UBF1/2_26484160_Chip-Seq_HMECs_Human1.21014391
108CDX2_20551321_ChIP-Seq_CACO-2_Human1.20991039
109AHR_22903824_ChIP-Seq_MCF-7_Human1.19321921
110SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18773004
111ZFX_18555785_Chip-Seq_ESCs_Mouse1.18304459
112AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.17763266
113PPARA_22158963_ChIP-Seq_LIVER_Mouse1.17214248
114SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16929744
115IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16462875
116BP1_19119308_ChIP-ChIP_Hs578T_Human1.16380323
117KLF4_18555785_Chip-Seq_ESCs_Mouse1.16004459
118GATA1_22025678_ChIP-Seq_K562_Human1.14420838
119KLF5_25053715_ChIP-Seq_YYC3_Human1.13814054
120RNF2_27304074_Chip-Seq_ESCs_Mouse1.13717920
121POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12607172
122Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.12117192
123SMAD3_21741376_ChIP-Seq_EPCs_Human1.11815289
124CTCF_18555785_Chip-Seq_ESCs_Mouse1.11086635
125CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10578304
126SMAD1_18555785_Chip-Seq_ESCs_Mouse1.10250110
127SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.09923439
128TCF4_18268006_ChIP-ChIP_LS174T_Human1.09357465
129P300_19829295_ChIP-Seq_ESCs_Human1.08507181
130SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07077756
131TAL1_26923725_Chip-Seq_HPCs_Mouse1.05729167
132STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05651423
133SMAD3_21741376_ChIP-Seq_HESCs_Human1.05333866
134TCF7_22412390_ChIP-Seq_EML_Mouse1.05204878
135POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05093937
136NFYB_21822215_ChIP-Seq_K562_Human1.04554492
137TP53_16413492_ChIP-PET_HCT116_Human1.03962461
138GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03797162
139TBL1_22424771_ChIP-Seq_293T_Human1.03038462
140ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02235570
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00446464
142EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99992262
143RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99016041
144LXR_22158963_ChIP-Seq_LIVER_Mouse0.98963580
145STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.97978471
146ELK3_25401928_ChIP-Seq_HUVEC_Human0.97043958
147JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96164493
148NFYA_21822215_ChIP-Seq_K562_Human0.95929627
149RNF2_27304074_Chip-Seq_NSC_Mouse0.95655331
150SMAD_19615063_ChIP-ChIP_OVARY_Human0.95157464
151GATA6_21074721_ChIP-Seq_CACO-2_Human0.95055310
152KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95010211
153EGR1_19032775_ChIP-ChIP_M12_Human0.94714695
154HNFA_21074721_ChIP-Seq_CACO-2_Human0.94350003
155* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94182897
156TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93890833
157FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92960821
158EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92503600
159ER_23166858_ChIP-Seq_MCF-7_Human0.92437776
160P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91059008
161TCF3_18692474_ChIP-Seq_MESCs_Mouse0.89003792
162RXR_22158963_ChIP-Seq_LIVER_Mouse0.88590782
163ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88365887
164JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87737738
165SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87147736
166CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86019653
167FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.85326914
168FOXA2_19822575_ChIP-Seq_HepG2_Human0.84381586
169MYB_21317192_ChIP-Seq_ERMYB_Mouse0.82949168
170MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.82553223
171ZNF263_19887448_ChIP-Seq_K562_Human0.82028174
172ARNT_22903824_ChIP-Seq_MCF-7_Human0.81910008
173FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.81806265
174NFIB_24661679_ChIP-Seq_LUNG_Mouse0.81605677
175HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81430768
176FOXA1_25552417_ChIP-Seq_VCAP_Human0.81287574
177EGR1_23403033_ChIP-Seq_LIVER_Mouse0.81058505
178CTCF_27219007_Chip-Seq_Bcells_Human0.80644603
179ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78226946
180CJUN_26792858_Chip-Seq_BT549_Human0.78169559
181PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.78110348
182NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78036060
183CEBPB_22108803_ChIP-Seq_LS180_Human0.76336216
184SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.74054261
185CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.73504971

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.96034145
2MP0005451_abnormal_body_composition4.90173697
3MP0001188_hyperpigmentation4.62071273
4MP0003941_abnormal_skin_development4.23659355
5MP0000383_abnormal_hair_follicle4.18239744
6MP0003191_abnormal_cellular_cholesterol3.95989883
7MP0003136_yellow_coat_color3.52973338
8MP0004381_abnormal_hair_follicle3.52749536
9MP0000579_abnormal_nail_morphology2.95222084
10MP0008438_abnormal_cutaneous_collagen2.89620715
11MP0010678_abnormal_skin_adnexa2.84680518
12MP0005409_darkened_coat_color2.78079997
13MP0009384_cardiac_valve_regurgitation2.77626620
14MP0001986_abnormal_taste_sensitivity2.60139155
15MP0002254_reproductive_system_inflammat2.36523642
16MP0002277_abnormal_respiratory_mucosa2.32880142
17MP0002060_abnormal_skin_morphology2.30808270
18MP0000566_synostosis2.29537566
19MP0004147_increased_porphyrin_level2.19625208
20MP0004782_abnormal_surfactant_physiolog2.18006383
21MP0009840_abnormal_foam_cell2.17027219
22MP0005275_abnormal_skin_tensile2.15376137
23MP0004264_abnormal_extraembryonic_tissu2.11392364
24MP0002796_impaired_skin_barrier2.11140727
25MP0005379_endocrine/exocrine_gland_phen2.07950353
26MP0002396_abnormal_hematopoietic_system1.92076678
27MP0002102_abnormal_ear_morphology1.91160494
28MP0005501_abnormal_skin_physiology1.83537867
29MP0001958_emphysema1.74921239
30MP0009379_abnormal_foot_pigmentation1.72039419
31MP0005387_immune_system_phenotype1.70721205
32MP0001790_abnormal_immune_system1.70721205
33MP0010771_integument_phenotype1.64170959
34MP0003705_abnormal_hypodermis_morpholog1.61067831
35MP0001299_abnormal_eye_distance/1.60064921
36MP0010352_gastrointestinal_tract_polyps1.56983259
37MP0005171_absent_coat_pigmentation1.55333107
38MP0003566_abnormal_cell_adhesion1.54356806
39MP0003950_abnormal_plasma_membrane1.53193017
40MP0000462_abnormal_digestive_system1.46094233
41MP0000467_abnormal_esophagus_morphology1.45913540
42MP0001853_heart_inflammation1.45498162
43MP0000685_abnormal_immune_system1.42940607
44MP0000427_abnormal_hair_cycle1.41830517
45MP0004142_abnormal_muscle_tone1.40946694
46MP0008058_abnormal_DNA_repair1.35443754
47MP0000367_abnormal_coat/_hair1.35141058
48MP0000647_abnormal_sebaceous_gland1.32785981
49MP0006292_abnormal_olfactory_placode1.32665882
50MP0002098_abnormal_vibrissa_morphology1.28635248
51MP0002933_joint_inflammation1.27870771
52MP0002249_abnormal_larynx_morphology1.24875195
53MP0001216_abnormal_epidermal_layer1.24347161
54MP0004272_abnormal_basement_membrane1.22001637
55MP0005671_abnormal_response_to1.20388381
56MP0003878_abnormal_ear_physiology1.19864589
57MP0005377_hearing/vestibular/ear_phenot1.19864589
58MP0004742_abnormal_vestibular_system1.15018013
59MP0010030_abnormal_orbit_morphology1.13121684
60MP0005623_abnormal_meninges_morphology1.12857256
61MP0000465_gastrointestinal_hemorrhage1.12385131
62MP0000920_abnormal_myelination1.11923061
63MP0001191_abnormal_skin_condition1.11746424
64MP0004947_skin_inflammation1.09733343
65MP0009250_abnormal_appendicular_skeleto1.05358804
66MP0005023_abnormal_wound_healing1.04326727
67MP0003279_aneurysm1.03864349
68MP0000613_abnormal_salivary_gland1.03341347
69MP0005257_abnormal_intraocular_pressure1.02352756
70MP0002111_abnormal_tail_morphology1.00929544
71MP0001486_abnormal_startle_reflex1.00743396
72MP0001800_abnormal_humoral_immune1.00537045
73MP0005174_abnormal_tail_pigmentation0.98852920
74MP0002177_abnormal_outer_ear0.95750461
75MP0002148_abnormal_hypersensitivity_rea0.94048941
76MP0001348_abnormal_lacrimal_gland0.93821710
77MP0001851_eye_inflammation0.92250246
78MP0008004_abnormal_stomach_pH0.91567217
79MP0006072_abnormal_retinal_apoptosis0.91140355
80MP0000049_abnormal_middle_ear0.88644957
81MP0000015_abnormal_ear_pigmentation0.88276648
82MP0004185_abnormal_adipocyte_glucose0.87760467
83MP0001784_abnormal_fluid_regulation0.86280976
84MP0002095_abnormal_skin_pigmentation0.82809798
85MP0002132_abnormal_respiratory_system0.82167279
86MP0001346_abnormal_lacrimal_gland0.81620757
87MP0005670_abnormal_white_adipose0.81485463
88MP0000490_abnormal_crypts_of0.80817029
89MP0005503_abnormal_tendon_morphology0.80436450
90MP0000377_abnormal_hair_follicle0.79955492
91MP0002723_abnormal_immune_serum0.78750530
92MP0003724_increased_susceptibility_to0.78444829
93MP0003300_gastrointestinal_ulcer0.77923516
94MP0009672_abnormal_birth_weight0.77869376
95MP0000026_abnormal_inner_ear0.77027413
96MP0001340_abnormal_eyelid_morphology0.76435598
97MP0000432_abnormal_head_morphology0.76148401
98MP0001243_abnormal_dermal_layer0.75841885
99MP0004133_heterotaxia0.75673493
100MP0003045_fibrosis0.75633558
101MP0005076_abnormal_cell_differentiation0.74786595
102MP0001963_abnormal_hearing_physiology0.72022399
103MP0005025_abnormal_response_to0.70330247
104MP0001835_abnormal_antigen_presentation0.69855210
105MP0003938_abnormal_ear_development0.69744300
106MP0005000_abnormal_immune_tolerance0.69417324
107MP0000762_abnormal_tongue_morphology0.68295210
108MP0002234_abnormal_pharynx_morphology0.67902320
109MP0001177_atelectasis0.67852562
110MP0002877_abnormal_melanocyte_morpholog0.66440210
111MP0000470_abnormal_stomach_morphology0.64526696
112MP0003453_abnormal_keratinocyte_physiol0.63096641
113MP0002452_abnormal_antigen_presenting0.61607025
114MP0008057_abnormal_DNA_replication0.61407349
115MP0002233_abnormal_nose_morphology0.60616870
116MP0005388_respiratory_system_phenotype0.60401638
117MP0002133_abnormal_respiratory_system0.60401638
118MP0003011_delayed_dark_adaptation0.59356183
119MP0006082_CNS_inflammation0.59339655
120MP0004808_abnormal_hematopoietic_stem0.59183919
121MP0002876_abnormal_thyroid_physiology0.58369220
122MP0005508_abnormal_skeleton_morphology0.58314472
123MP0005666_abnormal_adipose_tissue0.56435566
124MP0002420_abnormal_adaptive_immunity0.56101260
125MP0003763_abnormal_thymus_physiology0.55993580
126MP0009931_abnormal_skin_appearance0.54398908
127MP0002136_abnormal_kidney_physiology0.53999399
128MP0000703_abnormal_thymus_morphology0.53792672
129MP0004885_abnormal_endolymph0.52659361
130MP0009333_abnormal_splenocyte_physiolog0.47587849
131MP0000627_abnormal_mammary_gland0.46727534
132MP0009703_decreased_birth_body0.45563536
133MP0001873_stomach_inflammation0.44691707
134MP0002138_abnormal_hepatobiliary_system0.42299974
135MP0000858_altered_metastatic_potential0.42213955
136MP0010155_abnormal_intestine_physiology0.40835675
137MP0003221_abnormal_cardiomyocyte_apopto0.39137319
138MP0002009_preneoplasia0.37392339
139MP0005075_abnormal_melanosome_morpholog0.37144642
140MP0004197_abnormal_fetal_growth/weight/0.35604535
141MP0003828_pulmonary_edema0.35414201
142MP0002697_abnormal_eye_size0.35088863
143MP0008260_abnormal_autophagy0.35065127
144MP0003091_abnormal_cell_migration0.34361426
145MP0005248_abnormal_Harderian_gland0.30681911
146MP0002089_abnormal_postnatal_growth/wei0.30416889
147MP0002086_abnormal_extraembryonic_tissu0.29274122
148MP0004019_abnormal_vitamin_homeostasis0.27460601
149MP0005408_hypopigmentation0.26789576
150MP0003638_abnormal_response/metabolism_0.26624616
151MP0002295_abnormal_pulmonary_circulatio0.25467707
152MP0002998_abnormal_bone_remodeling0.24898310
153MP0006138_congestive_heart_failure0.23631875
154MP0003448_altered_tumor_morphology0.22050120
155MP0003436_decreased_susceptibility_to0.21994918
156MP0003656_abnormal_erythrocyte_physiolo0.21501758
157MP0005058_abnormal_lysosome_morphology0.21265911
158MP0003755_abnormal_palate_morphology0.20416122

Predicted human phenotypes

RankGene SetZ-score
1Palmoplantar hyperkeratosis (HP:0000972)7.35260420
2Palmar hyperkeratosis (HP:0010765)6.99765380
3Upper limb muscle weakness (HP:0003484)6.22149776
4Erythroderma (HP:0001019)6.13544238
5Erythema (HP:0010783)5.72609933
6Chromosomal breakage induced by crosslinking agents (HP:0003221)5.54135410
7Thick nail (HP:0001805)5.33689687
8Oral leukoplakia (HP:0002745)5.21799254
9Congenital stationary night blindness (HP:0007642)4.74913728
10Chromsome breakage (HP:0040012)4.59772086
11Right ventricular cardiomyopathy (HP:0011663)4.45852814
12Alopecia of scalp (HP:0002293)4.24181124
13Prostate neoplasm (HP:0100787)4.06688082
14Palmoplantar keratoderma (HP:0000982)4.00625370
15Abnormality of secondary sexual hair (HP:0009888)3.92701995
16Abnormality of the axillary hair (HP:0100134)3.92701995
17Gangrene (HP:0100758)3.89843310
18Parakeratosis (HP:0001036)3.79763034
19Nail dystrophy (HP:0008404)3.57123062
20Fragile nails (HP:0001808)3.48449783
21Woolly hair (HP:0002224)3.31829319
22Mesomelia (HP:0003027)3.09892156
23Follicular hyperkeratosis (HP:0007502)3.05746733
24Pustule (HP:0200039)3.05386752
25Osteomalacia (HP:0002749)3.00800047
26Sparse scalp hair (HP:0002209)2.98274069
27Malnutrition (HP:0004395)2.95993081
28Absent eyelashes (HP:0000561)2.89832430
29Microvesicular hepatic steatosis (HP:0001414)2.89681929
30Distal lower limb amyotrophy (HP:0008944)2.86409780
31Abnormality of the salivary glands (HP:0010286)2.85004205
32Septo-optic dysplasia (HP:0100842)2.83596894
33Distal lower limb muscle weakness (HP:0009053)2.79936228
34Abnormal blistering of the skin (HP:0008066)2.79235654
35Nephroblastoma (Wilms tumor) (HP:0002667)2.77646685
36Dehydration (HP:0001944)2.73501773
37Atrophic scars (HP:0001075)2.70254599
38Loss of speech (HP:0002371)2.68767537
39Onycholysis (HP:0001806)2.67313456
40Embryonal renal neoplasm (HP:0011794)2.64708363
41Pili torti (HP:0003777)2.63188481
42Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.62078825
43Sparse eyelashes (HP:0000653)2.62033250
44Natal tooth (HP:0000695)2.56970067
45Premature rupture of membranes (HP:0001788)2.52335984
46Febrile seizures (HP:0002373)2.50854595
47Conical tooth (HP:0000698)2.48966925
48Chronic diarrhea (HP:0002028)2.46786163
49Lower limb amyotrophy (HP:0007210)2.46411965
50Conjunctival hamartoma (HP:0100780)2.45317867
51Ectropion (HP:0000656)2.43523959
52Lack of skin elasticity (HP:0100679)2.39934929
53Hyperhidrosis (HP:0000975)2.38033585
54Agammaglobulinemia (HP:0004432)2.34616238
55Absent hair (HP:0002298)2.33922173
56Broad metatarsal (HP:0001783)2.31380193
57Duplicated collecting system (HP:0000081)2.31170709
58Abnormality of the parathyroid morphology (HP:0011766)2.29952582
59Recurrent pneumonia (HP:0006532)2.28621328
60Metaphyseal irregularity (HP:0003025)2.26806658
61Abnormal hair laboratory examination (HP:0003328)2.25842959
62Advanced eruption of teeth (HP:0006288)2.25248026
63Curly hair (HP:0002212)2.25185636
64Craniofacial hyperostosis (HP:0004493)2.24359086
65Laryngomalacia (HP:0001601)2.24159089
66Onion bulb formation (HP:0003383)2.19723691
67Congenital ichthyosiform erythroderma (HP:0007431)2.19722884
68Aplasia/Hypoplasia of the sacrum (HP:0008517)2.17136255
69Abnormality of the prostate (HP:0008775)2.12705434
70Hypergammaglobulinemia (HP:0010702)2.10031922
71Vertebral compression fractures (HP:0002953)2.08981343
72Abnormality of the preputium (HP:0100587)2.08469954
73Partial agenesis of the corpus callosum (HP:0001338)2.06279788
74Aplasia/Hypoplasia of the uvula (HP:0010293)2.05228478
75Eczematoid dermatitis (HP:0000976)2.04506901
76Villous atrophy (HP:0011473)2.04155331
77Abnormality of small intestinal villus morphology (HP:0011472)2.04155331
78Broad ribs (HP:0000885)2.03557334
79Hypoplasia of the iris (HP:0007676)2.03276134
80Recurrent sinusitis (HP:0011108)2.03129648
81Aplasia cutis congenita (HP:0001057)2.02697213
82Fragile skin (HP:0001030)2.01592230
83Abnormality of the renal collecting system (HP:0004742)2.01215530
84Acute lymphatic leukemia (HP:0006721)2.00779724
85Tibial bowing (HP:0002982)2.00435013
86Blepharitis (HP:0000498)2.00121490
87Morphological abnormality of the middle ear (HP:0008609)2.00089786
88Abnormality of nail color (HP:0100643)11.6704365
89Verrucae (HP:0200043)1.99991461
90Papilloma (HP:0012740)1.99991461
91Single umbilical artery (HP:0001195)1.99613355
92Abnormality of the fetal cardiovascular system (HP:0010948)1.99613355
93Abnormal umbilical cord blood vessels (HP:0011403)1.99613355
94Lip pit (HP:0100267)1.96957307
95Brittle hair (HP:0002299)1.95376569
96Abnormality of glycolipid metabolism (HP:0010969)1.94049341
97Abnormality of liposaccharide metabolism (HP:0010968)1.94049341
98Abnormality of glycosphingolipid metabolism (HP:0004343)1.94049341
99Abnormality of polysaccharide metabolism (HP:0011012)1.94049277
100Abnormality of glycosaminoglycan metabolism (HP:0004371)1.94049277
101Abnormality of mucopolysaccharide metabolism (HP:0011020)1.94049277
102Sepsis (HP:0100806)1.92671947
103Femoral bowing (HP:0002980)1.91718820
104Decreased central vision (HP:0007663)1.91550256
105Midline defect of the nose (HP:0004122)1.91291105
106Abnormality of monocarboxylic acid metabolism (HP:0010996)1.90793596
107Narrow nasal bridge (HP:0000446)1.89421566
108Cardiovascular calcification (HP:0011915)1.87570367
109Corneal erosion (HP:0200020)1.87212534
110Spontaneous abortion (HP:0005268)1.86460437
111Myelomeningocele (HP:0002475)1.86109028
112Meningitis (HP:0001287)1.86043762
113Ulnar bowing (HP:0003031)1.86037056
114Acanthosis nigricans (HP:0000956)1.85692822
115Recurrent lower respiratory tract infections (HP:0002783)1.85256486
116Abnormality of the right ventricle (HP:0001707)1.85154840
117Hypotrichosis (HP:0001006)1.84883533
118Hypohidrosis (HP:0000966)1.84041219
119Mediastinal lymphadenopathy (HP:0100721)1.83991479
120Selective tooth agenesis (HP:0001592)1.83839616
121Bradycardia (HP:0001662)1.83806683
122White forelock (HP:0002211)1.82527352
123Pruritus (HP:0000989)1.81968760
124Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81102389
125Increased IgE level (HP:0003212)1.79649887
126Cranial hyperostosis (HP:0004437)1.78627579
127Hypoplastic labia majora (HP:0000059)1.78424103
128Milia (HP:0001056)1.78098850
129Hypothermia (HP:0002045)1.77643585
130Premature skin wrinkling (HP:0100678)1.76704740
131Dry skin (HP:0000958)1.76686169
132Furrowed tongue (HP:0000221)1.76167745
133Urticaria (HP:0001025)1.75816102
134Clubbing of toes (HP:0100760)1.75765469
135Skin ulcer (HP:0200042)1.75639889
136Dry hair (HP:0011359)1.75155526
137Optic nerve hypoplasia (HP:0000609)1.74730445
138Anonychia (HP:0001798)1.74112564
139Cutaneous finger syndactyly (HP:0010554)1.73275897
140Wide anterior fontanel (HP:0000260)1.72104040
141Delayed cranial suture closure (HP:0000270)1.71473170
142Corneal dystrophy (HP:0001131)1.70023440
143Unilateral renal agenesis (HP:0000122)1.68628462
144Increased corneal curvature (HP:0100692)1.68579209
145Keratoconus (HP:0000563)1.68579209
146Cupped ear (HP:0000378)1.68160349
147Gastrointestinal stroma tumor (HP:0100723)1.67900836
148Renal cortical cysts (HP:0000803)1.67820277
149Ankyloglossia (HP:0010296)1.67291682
150Short middle phalanx of the 5th finger (HP:0004220)1.67213433
151Disproportionate tall stature (HP:0001519)1.66340137
152Plantar hyperkeratosis (HP:0007556)1.66100278
153Gingival bleeding (HP:0000225)1.64884263
154Abnormal ciliary motility (HP:0012262)1.64875933
155Flared iliac wings (HP:0002869)1.61484934
156Hamartoma of the eye (HP:0010568)1.61131173
157Vascular calcification (HP:0004934)1.59798727
158Hyperactive renin-angiotensin system (HP:0000841)1.59206503
159Renal agenesis (HP:0000104)1.58994256
160Abnormality of the labia majora (HP:0012881)1.58519302
161Slow-growing hair (HP:0002217)1.57197699
162Abnormality of hair growth rate (HP:0011363)1.57197699
163Fine hair (HP:0002213)1.56470107
164Seborrheic dermatitis (HP:0001051)1.55746391
165Popliteal pterygium (HP:0009756)1.53818970
166Flat acetabular roof (HP:0003180)1.53214473
167Carious teeth (HP:0000670)1.52985973
168Abnormality of the common coagulation pathway (HP:0010990)1.50118944
169Abnormality of permanent molar morphology (HP:0011071)1.49811092
170Abnormality of the dental root (HP:0006486)1.49811092
171Taurodontia (HP:0000679)1.49811092
172Abnormality of macrophages (HP:0004311)1.47639693
173Ridged nail (HP:0001807)1.44290968
174Tetraparesis (HP:0002273)1.40077566
175Abnormality of the gastric mucosa (HP:0004295)1.39597710
176Neonatal short-limb short stature (HP:0008921)1.38439607
177Hyperkalemia (HP:0002153)1.38247913
178Abnormality of molar (HP:0011077)1.36666078
179Abnormality of molar morphology (HP:0011070)1.36666078
180Melanocytic nevus (HP:0000995)1.35818139
181Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.34526190
182Coarse hair (HP:0002208)1.34349763
183Ventricular tachycardia (HP:0004756)1.34345429
184Abnormality of the fingernails (HP:0001231)1.33547240
185Abnormality of the dental pulp (HP:0006479)1.31861354

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.91803805
2TNIK4.46608817
3GRK13.92052411
4STK243.66685405
5EIF2AK23.49851769
6MAP3K92.67218928
7CASK2.58547055
8TXK2.29914421
9ERN12.21554184
10INSRR2.18724431
11MAP3K122.17524011
12PKN12.16150586
13MAP4K12.01935702
14MAP3K132.01733912
15PRPF4B1.90221180
16CLK11.89911418
17MAP3K21.77662817
18MUSK1.73193368
19MAPK71.69992087
20PIK3CG1.69962211
21CAMK1D1.56820033
22MST41.55175974
23AKT31.51044217
24ZAK1.50863444
25TRIB31.50274696
26MAP3K101.45404253
27EEF2K1.44661043
28YES11.44437497
29MAP3K31.40974843
30IRAK41.40067350
31FGFR11.38501108
32FER1.34544765
33TRPM71.34088972
34RIPK11.33249257
35IRAK21.32529885
36CDK121.32244128
37FGFR31.30191138
38TGFBR11.27534665
39SIK11.26102495
40TEC1.23556569
41TGFBR21.21016745
42MAPK151.20416693
43KIT1.20253984
44MAP3K61.18552450
45PIK3CA1.17162598
46STK391.16806269
47JAK11.15803072
48CSNK1A1L1.15097716
49NTRK31.13931248
50CAMK1G1.09302270
51MAP3K141.08248834
52MST1R1.07996258
53MAP3K11.07839437
54STK38L1.06886464
55ADRBK21.06868391
56CSF1R1.04295704
57EIF2AK31.04282846
58NEK61.02965249
59FGFR41.01925276
60STK41.00880336
61SGK2230.99140852
62SGK4940.99140852
63SMG10.97871909
64MARK20.96693681
65MTOR0.94778650
66PRKAA20.90687992
67PRKD20.90298591
68DDR20.89928408
69SGK30.89873435
70MAP3K70.89789985
71CSNK1G10.89339351
72WNK10.88926554
73TLK10.88898307
74LATS10.88743584
75LATS20.88185742
76BTK0.87748821
77BRD40.86858249
78STK100.85095488
79SGK20.84907563
80VRK10.84059949
81ICK0.83863923
82SYK0.82609731
83PRKCQ0.82229221
84PAK20.81332042
85LYN0.81016903
86PBK0.79785751
87MAPK120.79559937
88RPS6KA50.77282202
89ERBB40.77240198
90CDK60.76642443
91CAMK10.76448862
92IKBKB0.76119286
93CDK30.75677602
94GRK70.75649693
95BCR0.75477581
96GRK60.75201796
97OXSR10.73429029
98PTK20.71391208
99LCK0.69862724
100DYRK30.69034354
101DYRK20.68856639
102FGR0.68075715
103EPHB10.68050022
104EPHA20.67147690
105ITK0.66873694
106HCK0.65767470
107ABL20.65219295
108SIK20.64378440
109HIPK20.63356897
110KSR20.63188086
111MET0.62240761
112PDGFRA0.62128034
113PHKG20.61740293
114PHKG10.61740293
115PRKCH0.60689187
116TBK10.59576151
117CHUK0.59003877
118NLK0.58544443
119TNK20.57345696
120FYN0.56830473
121MELK0.56109900
122STK380.56092603
123PRKCE0.55663181
124STK30.55395802
125BRAF0.54896059
126LRRK20.53427567
127TAOK30.52517737
128PTK60.52008742
129MAP2K10.50227974
130CSNK1D0.48904712
131PRKG10.47031766
132PRKCI0.46891532
133CDK70.46295278
134IKBKE0.45564972
135TYRO30.45092544
136CSNK1G30.44785797
137PIM20.44119086
138RPS6KB20.44067698
139CAMK2D0.43889690
140PAK40.43606803
141SCYL20.43540301
142PRKD10.42855009
143INSR0.42501931
144CDC42BPA0.42038349
145CAMK2B0.41464930
146NME20.41306833
147MAPKAPK30.41262806
148LMTK20.40908793
149EPHA30.40798932
150RET0.40406005
151CAMK2G0.40111366
152BMX0.40060750
153TAOK10.39585743
154PRKACA0.37995147
155TESK20.37994042
156ABL10.37671577
157CSK0.37026268
158FES0.36964599
159IRAK30.36698573
160RPS6KB10.36041292
161PDK20.35029260
162MAPK40.34245979
163PDGFRB0.33758645
164MAP3K50.32569861
165DAPK20.31313508
166IRAK10.30455137

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.06787301
2Phototransduction_Homo sapiens_hsa047442.96627982
3Systemic lupus erythematosus_Homo sapiens_hsa053222.77226564
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.68922036
5Non-homologous end-joining_Homo sapiens_hsa034502.23643980
6Hematopoietic cell lineage_Homo sapiens_hsa046402.23609650
7Primary immunodeficiency_Homo sapiens_hsa053402.22829525
8Fatty acid elongation_Homo sapiens_hsa000622.18715449
9ABC transporters_Homo sapiens_hsa020101.93095488
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88523214
11Sphingolipid metabolism_Homo sapiens_hsa006001.79873579
12GnRH signaling pathway_Homo sapiens_hsa049121.78192292
13Phosphatidylinositol signaling system_Homo sapiens_hsa040701.75927462
14Fanconi anemia pathway_Homo sapiens_hsa034601.75339343
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.70225975
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.70030302
17Thyroid cancer_Homo sapiens_hsa052161.69971763
18Inositol phosphate metabolism_Homo sapiens_hsa005621.67481556
19ECM-receptor interaction_Homo sapiens_hsa045121.64778098
20Axon guidance_Homo sapiens_hsa043601.63996649
21VEGF signaling pathway_Homo sapiens_hsa043701.59517057
22Alcoholism_Homo sapiens_hsa050341.58759200
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.55486483
24Tight junction_Homo sapiens_hsa045301.50771929
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.50670607
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.50586428
27Malaria_Homo sapiens_hsa051441.49058156
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.47935523
29B cell receptor signaling pathway_Homo sapiens_hsa046621.45982868
30Adherens junction_Homo sapiens_hsa045201.45388026
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41057522
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.40121773
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39593825
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39277188
35Protein digestion and absorption_Homo sapiens_hsa049741.32461443
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31217058
37Circadian rhythm_Homo sapiens_hsa047101.26538517
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.24010422
39Basal cell carcinoma_Homo sapiens_hsa052171.23241029
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23107021
41Acute myeloid leukemia_Homo sapiens_hsa052211.18590042
42Steroid biosynthesis_Homo sapiens_hsa001001.16267437
43Toxoplasmosis_Homo sapiens_hsa051451.15999194
44Hepatitis C_Homo sapiens_hsa051601.13693933
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13232982
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.12256970
47Endometrial cancer_Homo sapiens_hsa052131.08434985
48Ether lipid metabolism_Homo sapiens_hsa005651.07435925
49Bladder cancer_Homo sapiens_hsa052191.07115155
50Measles_Homo sapiens_hsa051621.06210002
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05517856
52Renal cell carcinoma_Homo sapiens_hsa052111.05320172
53T cell receptor signaling pathway_Homo sapiens_hsa046601.02757904
54Homologous recombination_Homo sapiens_hsa034401.01974217
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01714476
56Arachidonic acid metabolism_Homo sapiens_hsa005901.00419295
57Long-term depression_Homo sapiens_hsa047300.98331376
58Other glycan degradation_Homo sapiens_hsa005110.97976403
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.96843087
60Retinol metabolism_Homo sapiens_hsa008300.96601371
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95779182
62Autoimmune thyroid disease_Homo sapiens_hsa053200.94517616
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94228807
64Osteoclast differentiation_Homo sapiens_hsa043800.93202876
65Endocytosis_Homo sapiens_hsa041440.92468911
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92251830
67beta-Alanine metabolism_Homo sapiens_hsa004100.91733903
68Fat digestion and absorption_Homo sapiens_hsa049750.89875071
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89446004
70Taste transduction_Homo sapiens_hsa047420.88785174
71ErbB signaling pathway_Homo sapiens_hsa040120.88031611
72Chemokine signaling pathway_Homo sapiens_hsa040620.85222285
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84768766
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.83981025
75Ovarian steroidogenesis_Homo sapiens_hsa049130.81235985
76Chronic myeloid leukemia_Homo sapiens_hsa052200.80615407
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80546116
78Small cell lung cancer_Homo sapiens_hsa052220.78148274
79Morphine addiction_Homo sapiens_hsa050320.77842071
80Proteoglycans in cancer_Homo sapiens_hsa052050.76258440
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75053900
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74834473
83Calcium signaling pathway_Homo sapiens_hsa040200.74393682
84Influenza A_Homo sapiens_hsa051640.74339977
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.73568081
86Notch signaling pathway_Homo sapiens_hsa043300.73347196
87Non-small cell lung cancer_Homo sapiens_hsa052230.72347995
88Staphylococcus aureus infection_Homo sapiens_hsa051500.72245636
89Pancreatic cancer_Homo sapiens_hsa052120.72185767
90Wnt signaling pathway_Homo sapiens_hsa043100.71792800
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.69416793
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69280490
93FoxO signaling pathway_Homo sapiens_hsa040680.68956576
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67378687
95Ras signaling pathway_Homo sapiens_hsa040140.67092263
96Prostate cancer_Homo sapiens_hsa052150.66987698
97Hippo signaling pathway_Homo sapiens_hsa043900.65233822
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65032432
99Shigellosis_Homo sapiens_hsa051310.64149555
100Apoptosis_Homo sapiens_hsa042100.64148594
101Melanoma_Homo sapiens_hsa052180.63799702
102Linoleic acid metabolism_Homo sapiens_hsa005910.63526373
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62719486
104Complement and coagulation cascades_Homo sapiens_hsa046100.62549451
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.62518320
106Histidine metabolism_Homo sapiens_hsa003400.61995737
107Lysosome_Homo sapiens_hsa041420.61436416
108Serotonergic synapse_Homo sapiens_hsa047260.60472417
109Viral carcinogenesis_Homo sapiens_hsa052030.60155228
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60125190
111Dorso-ventral axis formation_Homo sapiens_hsa043200.59531777
112Platelet activation_Homo sapiens_hsa046110.59083007
113Pathways in cancer_Homo sapiens_hsa052000.58755479
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58702547
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58432498
116Rheumatoid arthritis_Homo sapiens_hsa053230.58385801
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57668130
118Glioma_Homo sapiens_hsa052140.57634373
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57599707
120MAPK signaling pathway_Homo sapiens_hsa040100.57419821
121Insulin signaling pathway_Homo sapiens_hsa049100.54897984
122Leishmaniasis_Homo sapiens_hsa051400.54495344
123Propanoate metabolism_Homo sapiens_hsa006400.52880519
124TNF signaling pathway_Homo sapiens_hsa046680.52689447
125Mineral absorption_Homo sapiens_hsa049780.50576590
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.50576339
127One carbon pool by folate_Homo sapiens_hsa006700.49577620
128Vitamin digestion and absorption_Homo sapiens_hsa049770.49117882
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49098541
130TGF-beta signaling pathway_Homo sapiens_hsa043500.48976747
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.48341216
132cAMP signaling pathway_Homo sapiens_hsa040240.47973920
133Cocaine addiction_Homo sapiens_hsa050300.47973750
134p53 signaling pathway_Homo sapiens_hsa041150.47103887
135Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46968154
136MicroRNAs in cancer_Homo sapiens_hsa052060.46516726
137Viral myocarditis_Homo sapiens_hsa054160.45887269
138Glutamatergic synapse_Homo sapiens_hsa047240.45868259
139Choline metabolism in cancer_Homo sapiens_hsa052310.45595597
140Nicotine addiction_Homo sapiens_hsa050330.45340975
141Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45271046
142Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44429082
143Tuberculosis_Homo sapiens_hsa051520.44319538
144Herpes simplex infection_Homo sapiens_hsa051680.43811907
145Renin secretion_Homo sapiens_hsa049240.42796355
146Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42068269
147Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41673718
148Amoebiasis_Homo sapiens_hsa051460.41316289
149Fatty acid biosynthesis_Homo sapiens_hsa000610.41156368
150Vibrio cholerae infection_Homo sapiens_hsa051100.41106945
151Focal adhesion_Homo sapiens_hsa045100.40914334
152Galactose metabolism_Homo sapiens_hsa000520.40633667
153Fatty acid metabolism_Homo sapiens_hsa012120.39007042
154Rap1 signaling pathway_Homo sapiens_hsa040150.37422557

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