XIAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gamma-aminobutyric acid transport (GO:0015812)8.63183485
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.81016341
3L-phenylalanine catabolic process (GO:0006559)4.81016341
4endocardial cushion morphogenesis (GO:0003203)4.74808522
5alpha-linolenic acid metabolic process (GO:0036109)4.63601120
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.45759374
7behavioral response to nicotine (GO:0035095)4.42691586
8sodium-independent organic anion transport (GO:0043252)4.38911434
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.37071947
10L-phenylalanine metabolic process (GO:0006558)4.37071947
11aromatic amino acid family catabolic process (GO:0009074)4.31635670
12urea metabolic process (GO:0019627)4.21228687
13urea cycle (GO:0000050)4.21228687
14cAMP catabolic process (GO:0006198)4.13804704
15dicarboxylic acid biosynthetic process (GO:0043650)4.13177783
16complement activation, alternative pathway (GO:0006957)4.12545866
17regulation of protein activation cascade (GO:2000257)4.10667716
18positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.97394863
19mesenchyme morphogenesis (GO:0072132)3.97070218
20kynurenine metabolic process (GO:0070189)3.94925713
21bile acid biosynthetic process (GO:0006699)3.94051248
22tryptophan catabolic process (GO:0006569)3.91140856
23indole-containing compound catabolic process (GO:0042436)3.91140856
24indolalkylamine catabolic process (GO:0046218)3.91140856
25regulation of complement activation (GO:0030449)3.90663593
26peptidyl-glutamic acid carboxylation (GO:0017187)3.86708741
27protein carboxylation (GO:0018214)3.86708741
28cardiac right ventricle morphogenesis (GO:0003215)3.76741014
29tryptophan metabolic process (GO:0006568)3.75636711
30high-density lipoprotein particle remodeling (GO:0034375)3.73893707
31cyclic nucleotide catabolic process (GO:0009214)3.72903134
32Notch signaling involved in heart development (GO:0061314)3.71286263
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.66661308
34nitrogen cycle metabolic process (GO:0071941)3.66429540
35negative regulation of fibrinolysis (GO:0051918)3.65423294
36intestinal epithelial cell development (GO:0060576)3.60132016
37reverse cholesterol transport (GO:0043691)3.58379620
38negative regulation of hormone biosynthetic process (GO:0032353)3.56407417
39regulation of fibrinolysis (GO:0051917)3.54629875
40cellular hyperosmotic response (GO:0071474)3.52822276
41phospholipid homeostasis (GO:0055091)3.51895281
42glyoxylate metabolic process (GO:0046487)3.46076982
43bile acid metabolic process (GO:0008206)3.42002493
44cysteine metabolic process (GO:0006534)3.41798018
45cholesterol efflux (GO:0033344)3.39734560
46glutamate metabolic process (GO:0006536)3.39276361
47plasma lipoprotein particle clearance (GO:0034381)3.38875090
48phospholipid efflux (GO:0033700)3.37133393
49regulation of triglyceride catabolic process (GO:0010896)3.35137196
50protein-lipid complex remodeling (GO:0034368)3.32534627
51macromolecular complex remodeling (GO:0034367)3.32534627
52plasma lipoprotein particle remodeling (GO:0034369)3.32534627
53acylglycerol homeostasis (GO:0055090)3.30294400
54triglyceride homeostasis (GO:0070328)3.30294400
55regulation of cholesterol homeostasis (GO:2000188)3.28899106
56lysine metabolic process (GO:0006553)3.26848771
57lysine catabolic process (GO:0006554)3.26848771
58sulfur amino acid catabolic process (GO:0000098)3.24373742
59homocysteine metabolic process (GO:0050667)3.21144075
60regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.20551082
61negative regulation of sterol transport (GO:0032372)3.19737577
62negative regulation of cholesterol transport (GO:0032375)3.19737577
63plasma lipoprotein particle assembly (GO:0034377)3.18559166
64interkinetic nuclear migration (GO:0022027)3.15318049
65negative regulation of hormone metabolic process (GO:0032351)3.10956365
66bile acid and bile salt transport (GO:0015721)3.09480634
67nephron tubule formation (GO:0072079)3.09112136
68positive regulation of lipid catabolic process (GO:0050996)3.08964335
69tyrosine metabolic process (GO:0006570)3.07326384
70cGMP biosynthetic process (GO:0006182)3.03671665
71protein-lipid complex assembly (GO:0065005)3.02168810
72receptor guanylyl cyclase signaling pathway (GO:0007168)2.96049970
73positive regulation of fatty acid beta-oxidation (GO:0032000)2.93402338
74potassium ion import (GO:0010107)2.93094716
75cellular response to ATP (GO:0071318)2.92394891
76inositol phosphate-mediated signaling (GO:0048016)2.90693788
77amino-acid betaine metabolic process (GO:0006577)2.90577207
78auditory receptor cell differentiation (GO:0042491)2.89696414
79lipoprotein transport (GO:0042953)2.88969379
80somite rostral/caudal axis specification (GO:0032525)2.88598569
81glomerulus development (GO:0032835)2.87441996
82aromatic amino acid family metabolic process (GO:0009072)2.86589726
83heart valve morphogenesis (GO:0003179)2.85812308
84metanephric mesenchyme development (GO:0072075)2.85301927
85negative regulation of cytosolic calcium ion concentration (GO:0051481)2.85299583
86alpha-amino acid catabolic process (GO:1901606)2.84820417
87midgut development (GO:0007494)2.83489563
88plasma lipoprotein particle organization (GO:0071827)2.80546121
89regulation of cholesterol esterification (GO:0010872)2.80433838
90lipoprotein metabolic process (GO:0042157)2.80019667
91negative regulation of protein activation cascade (GO:2000258)2.78530312
92sterol homeostasis (GO:0055092)2.76866091
93cellular glucuronidation (GO:0052695)2.76741737
94cytolysis (GO:0019835)2.76394946
95cholesterol homeostasis (GO:0042632)2.76092295
96regulation of bile acid biosynthetic process (GO:0070857)2.74613547
97protein-lipid complex subunit organization (GO:0071825)2.73481595
98ethanol oxidation (GO:0006069)2.73025875
99negative regulation of DNA repair (GO:0045738)2.70835056
100very-low-density lipoprotein particle assembly (GO:0034379)2.70329728
101cellular modified amino acid catabolic process (GO:0042219)2.68446127
102aorta morphogenesis (GO:0035909)2.67587411
103toxin metabolic process (GO:0009404)2.66702773
104indolalkylamine metabolic process (GO:0006586)2.66689698
105low-density lipoprotein particle clearance (GO:0034383)2.66054474
106coenzyme catabolic process (GO:0009109)2.64351906
107negative regulation of lipase activity (GO:0060192)2.63997593
108renal tubule morphogenesis (GO:0061333)2.63973098
109serine family amino acid catabolic process (GO:0009071)2.62977397
110complement activation, classical pathway (GO:0006958)2.62655079
111fibrinolysis (GO:0042730)2.62528777
112complement activation (GO:0006956)2.61849773
113cellular amino acid catabolic process (GO:0009063)2.60995892
114heart valve formation (GO:0003188)2.60607832
115positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)2.60423468
116exogenous drug catabolic process (GO:0042738)2.58860712
117cellular ketone body metabolic process (GO:0046950)2.58717323
118drug catabolic process (GO:0042737)2.58704840
119low-density lipoprotein particle remodeling (GO:0034374)2.58703612
120regulation of cholesterol storage (GO:0010885)2.58112780
121negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.58003137
122negative regulation of translation, ncRNA-mediated (GO:0040033)2.58003137
123regulation of translation, ncRNA-mediated (GO:0045974)2.58003137
124basic amino acid transport (GO:0015802)2.57675517
125regulation of fatty acid beta-oxidation (GO:0031998)2.57156962
126cGMP metabolic process (GO:0046068)2.56084299
127epoxygenase P450 pathway (GO:0019373)2.55271481
128glycoprotein catabolic process (GO:0006516)2.54059862
129arginine metabolic process (GO:0006525)2.53095672
130short-chain fatty acid metabolic process (GO:0046459)2.53052750
131acetyl-CoA metabolic process (GO:0006084)2.52596556
132fatty acid transmembrane transport (GO:1902001)2.51993699
133lipid homeostasis (GO:0055088)2.51583421
134positive regulation of fatty acid oxidation (GO:0046321)2.50156489
135benzene-containing compound metabolic process (GO:0042537)2.49961591
136cholesterol transport (GO:0030301)2.49803134
137sterol transport (GO:0015918)2.49803134
138protein localization to endosome (GO:0036010)2.49519265
139protein activation cascade (GO:0072376)2.47240447
140macroautophagy (GO:0016236)2.47071642
141epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.46393584
142ovulation from ovarian follicle (GO:0001542)2.45394128
143retinal cone cell development (GO:0046549)2.44891077
144behavioral response to ethanol (GO:0048149)2.44672801
145positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.41720892
146kidney morphogenesis (GO:0060993)2.39648194
147cytoplasmic mRNA processing body assembly (GO:0033962)2.39286445
148positive regulation of phosphatase activity (GO:0010922)2.39099142
149regulation of energy homeostasis (GO:2000505)2.38128480
150regulation of pigment cell differentiation (GO:0050932)2.37746275
151cellular response to ethanol (GO:0071361)2.36526163
152pharyngeal system development (GO:0060037)2.35984671
153serotonin metabolic process (GO:0042428)2.34086799
154mesenchymal cell development (GO:0014031)2.34061144
155kidney mesenchyme development (GO:0072074)2.33793387
156neural tube formation (GO:0001841)2.33310024
157neuronal stem cell maintenance (GO:0097150)2.32287791
158atrial cardiac muscle cell action potential (GO:0086014)2.32217204
159regulation of sequestering of triglyceride (GO:0010889)2.31988780
160glomerular filtration (GO:0003094)2.31567466
161phosphatidylinositol acyl-chain remodeling (GO:0036149)2.31555563
162sulfation (GO:0051923)2.30989221
163magnesium ion transport (GO:0015693)2.30415830
164membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.29639880
165negative regulation of smooth muscle cell differentiation (GO:0051151)2.29493092
166tyrosine phosphorylation of STAT protein (GO:0007260)2.29198706
167regulation of hippo signaling (GO:0035330)2.29049694
168embryonic axis specification (GO:0000578)2.28978235
169prostate gland growth (GO:0060736)2.28509418
170transmission of nerve impulse (GO:0019226)2.27749305
171N-glycan processing (GO:0006491)2.27291105
172cardiac ventricle morphogenesis (GO:0003208)2.27026689
173bicarbonate transport (GO:0015701)2.26533447
174regulation of DNA endoreduplication (GO:0032875)2.21252051
175nephron epithelium morphogenesis (GO:0072088)2.21027089
176nephron tubule morphogenesis (GO:0072078)2.21027089
177growth hormone receptor signaling pathway (GO:0060396)2.20559053
178nucleus localization (GO:0051647)2.20251746
179stem cell development (GO:0048864)2.19924190
180cyclic nucleotide metabolic process (GO:0009187)2.19232478
181positive regulation of oligodendrocyte differentiation (GO:0048714)2.19191976
182indole-containing compound metabolic process (GO:0042430)2.18335264
183L-fucose catabolic process (GO:0042355)2.18267656
184fucose catabolic process (GO:0019317)2.18267656
185L-fucose metabolic process (GO:0042354)2.18267656
186alkaloid metabolic process (GO:0009820)2.15918411
187regulation of fatty acid oxidation (GO:0046320)2.15685952
188positive regulation of vascular permeability (GO:0043117)2.14896709

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.67334115
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.25479622
3LXR_22158963_ChIP-Seq_LIVER_Mouse3.78121717
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.53670527
5EGR1_23403033_ChIP-Seq_LIVER_Mouse2.96562253
6NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.68034746
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.55644837
8VDR_22108803_ChIP-Seq_LS180_Human2.55176851
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37594034
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.34245724
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.08727125
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02630906
13ER_23166858_ChIP-Seq_MCF-7_Human1.88753797
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85432830
15EZH2_22144423_ChIP-Seq_EOC_Human1.83669534
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.82990552
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81635312
18FUS_26573619_Chip-Seq_HEK293_Human1.81133866
19P300_19829295_ChIP-Seq_ESCs_Human1.76877698
20CLOCK_20551151_ChIP-Seq_293T_Human1.76159508
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.75109361
22ZNF274_21170338_ChIP-Seq_K562_Hela1.72454172
23FOXA2_19822575_ChIP-Seq_HepG2_Human1.71426193
24GATA1_22025678_ChIP-Seq_K562_Human1.68429763
25* TAF15_26573619_Chip-Seq_HEK293_Human1.67877719
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60193665
27EWS_26573619_Chip-Seq_HEK293_Human1.58900279
28BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.56886939
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56338640
30MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55231055
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.54968446
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54107108
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53819326
34ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52651597
35Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51064186
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.50591490
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47551642
38CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.46342938
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45885396
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45763515
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45039127
42AR_25329375_ChIP-Seq_VCAP_Human1.44591288
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.43135936
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42150298
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41548581
46TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40737816
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39895331
48TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.39892586
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.38139165
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36970497
51TCF4_23295773_ChIP-Seq_U87_Human1.35071592
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.34450554
53STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.33243284
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33041154
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32785386
56NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32785386
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31699264
58* FOXO3_23340844_ChIP-Seq_DLD1_Human1.31492515
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.30869836
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29144553
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29023892
62STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.27391136
63FLI1_21867929_ChIP-Seq_TH2_Mouse1.26768099
64CBP_20019798_ChIP-Seq_JUKART_Human1.24856597
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24856597
66ESR1_20079471_ChIP-ChIP_T-47D_Human1.22493986
67IRF8_22096565_ChIP-ChIP_GC-B_Human1.21866681
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20876665
69IGF1R_20145208_ChIP-Seq_DFB_Human1.19881108
70SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19371910
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19209894
72TRIM28_21343339_ChIP-Seq_HEK293_Human1.18853504
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18853358
74TP53_16413492_ChIP-PET_HCT116_Human1.18824251
75KDM2B_26808549_Chip-Seq_REH_Human1.18395927
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.17851127
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17036059
78JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16523106
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.16279682
80CDX2_22108803_ChIP-Seq_LS180_Human1.16001795
81PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15752799
82P53_22387025_ChIP-Seq_ESCs_Mouse1.15666203
83RUNX2_22187159_ChIP-Seq_PCA_Human1.15281242
84RUNX_20019798_ChIP-Seq_JUKART_Human1.14725052
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.14362994
86TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.13341441
87ESR2_21235772_ChIP-Seq_MCF-7_Human1.13209727
88TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12758153
89E2F1_18555785_Chip-Seq_ESCs_Mouse1.12400627
90TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.11898278
91SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11415370
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.10665033
93SMAD4_21741376_ChIP-Seq_EPCs_Human1.09805241
94SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09345416
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08785823
96GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08623413
97SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.08216160
98NOTCH1_21737748_ChIP-Seq_TLL_Human1.08205990
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07776240
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07431170
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07431170
102BCAT_22108803_ChIP-Seq_LS180_Human1.06685806
103CMYC_18555785_Chip-Seq_ESCs_Mouse1.06627197
104TP53_18474530_ChIP-ChIP_U2OS_Human1.05601827
105MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05543294
106* AHR_22903824_ChIP-Seq_MCF-7_Human1.05166938
107SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04968589
108AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04068719
109TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03954284
110SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02929511
111IRF8_27001747_Chip-Seq_BMDM_Mouse1.01415312
112SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01369955
113TCF4_18268006_ChIP-ChIP_LS174T_Human1.01159062
114GBX2_23144817_ChIP-Seq_PC3_Human1.00877363
115* ARNT_22903824_ChIP-Seq_MCF-7_Human0.99751791
116EP300_21415370_ChIP-Seq_HL-1_Mouse0.98975527
117RXR_22108803_ChIP-Seq_LS180_Human0.98915498
118SALL1_21062744_ChIP-ChIP_HESCs_Human0.97961886
119HNF4A_19822575_ChIP-Seq_HepG2_Human0.97304253
120CDX2_20551321_ChIP-Seq_CACO-2_Human0.96541869
121FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95734081
122CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94697481
123AR_21572438_ChIP-Seq_LNCaP_Human0.94477509
124SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.92867568
125NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92788297
126FOXA1_25552417_ChIP-Seq_VCAP_Human0.91371016
127ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90977809
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90712144
129GATA1_19941826_ChIP-Seq_K562_Human0.90370657
130DROSHA_22980978_ChIP-Seq_HELA_Human0.89291215
131WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88591836
132STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88021842
133SOX2_20726797_ChIP-Seq_SW620_Human0.87897281
134TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87800089
135VDR_24787735_ChIP-Seq_THP-1_Human0.87385093
136TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87072453
137PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86564110
138* CJUN_26792858_Chip-Seq_BT549_Human0.86484659
139SMAD4_21799915_ChIP-Seq_A2780_Human0.84789137
140WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84755078
141* TP63_23658742_ChIP-Seq_EP156T_Human0.84736964
142FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84661066
143STAT3_23295773_ChIP-Seq_U87_Human0.83791935
144MTF2_20144788_ChIP-Seq_MESCs_Mouse0.83688013
145PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.83400420
146WT1_19549856_ChIP-ChIP_CCG9911_Human0.83227883
147CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83223362
148NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83186668
149NR3C1_23031785_ChIP-Seq_PC12_Mouse0.83100026
150SOX2_21211035_ChIP-Seq_LN229_Gbm0.82653501
151GATA2_19941826_ChIP-Seq_K562_Human0.82284718
152STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.81665916
153FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81002160
154VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.80695425
155* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79997161
156KDM2B_26808549_Chip-Seq_K562_Human0.79418857
157FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78835240
158CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.78602294
159THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78510671
160POU3F2_20337985_ChIP-ChIP_501MEL_Human0.78495550
161TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.78382644
162ESR1_21235772_ChIP-Seq_MCF-7_Human0.78133921
163SOX9_24532713_ChIP-Seq_HFSC_Mouse0.77684495

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.16469741
2MP0002139_abnormal_hepatobiliary_system6.04853940
3MP0005085_abnormal_gallbladder_physiolo4.84429948
4MP0005365_abnormal_bile_salt4.54457662
5MP0002009_preneoplasia4.22147196
6MP0008875_abnormal_xenobiotic_pharmacok3.77546679
7MP0003011_delayed_dark_adaptation3.71477504
8MP0003252_abnormal_bile_duct3.68704290
9MP0008877_abnormal_DNA_methylation3.60837024
10MP0010329_abnormal_lipoprotein_level3.18047911
11MP0001986_abnormal_taste_sensitivity2.92577217
12MP0005551_abnormal_eye_electrophysiolog2.49496037
13MP0003705_abnormal_hypodermis_morpholog2.49096646
14MP0003283_abnormal_digestive_organ2.44629303
15MP0010386_abnormal_urinary_bladder2.44472352
16MP0003191_abnormal_cellular_cholesterol2.37942336
17MP0001501_abnormal_sleep_pattern2.36988480
18MP0010234_abnormal_vibrissa_follicle2.36104248
19MP0010368_abnormal_lymphatic_system2.29132468
20MP0003890_abnormal_embryonic-extraembry2.22971112
21MP0001666_abnormal_nutrient_absorption2.19078900
22MP0000427_abnormal_hair_cycle2.16019066
23MP0005167_abnormal_blood-brain_barrier2.11543175
24MP0005645_abnormal_hypothalamus_physiol2.10731895
25MP0009840_abnormal_foam_cell2.04580366
26MP0004043_abnormal_pH_regulation2.04545712
27MP0005083_abnormal_biliary_tract2.03252932
28MP0002138_abnormal_hepatobiliary_system1.93973008
29MP0004142_abnormal_muscle_tone1.84545892
30MP0000609_abnormal_liver_physiology1.83543257
31MP0002118_abnormal_lipid_homeostasis1.79017437
32MP0000013_abnormal_adipose_tissue1.76367412
33MP0004130_abnormal_muscle_cell1.74457157
34MP0004019_abnormal_vitamin_homeostasis1.71283622
35MP0005332_abnormal_amino_acid1.70886337
36MP0003300_gastrointestinal_ulcer1.70784089
37MP0001485_abnormal_pinna_reflex1.65346051
38MP0003787_abnormal_imprinting1.58193357
39MP0003136_yellow_coat_color1.57344730
40MP0000631_abnormal_neuroendocrine_gland1.54313901
41MP0001879_abnormal_lymphatic_vessel1.53093401
42MP0005174_abnormal_tail_pigmentation1.52406047
43MP0003690_abnormal_glial_cell1.47188447
44MP0000569_abnormal_digit_pigmentation1.46817713
45MP0002277_abnormal_respiratory_mucosa1.45896450
46MP0005595_abnormal_vascular_smooth1.44654937
47MP0005253_abnormal_eye_physiology1.44574759
48MP0003868_abnormal_feces_composition1.43905756
49MP0009046_muscle_twitch1.40126918
50MP0003183_abnormal_peptide_metabolism1.37391605
51MP0009745_abnormal_behavioral_response1.35606502
52MP0002090_abnormal_vision1.34967364
53MP0003195_calcinosis1.34587644
54MP0004484_altered_response_of1.29958836
55MP0002163_abnormal_gland_morphology1.26100268
56MP0005584_abnormal_enzyme/coenzyme_acti1.26091194
57MP0002638_abnormal_pupillary_reflex1.23933551
58MP0005409_darkened_coat_color1.23411392
59MP0005319_abnormal_enzyme/_coenzyme1.22092973
60MP0002254_reproductive_system_inflammat1.21631923
61MP0010678_abnormal_skin_adnexa1.20190802
62MP0003806_abnormal_nucleotide_metabolis1.20189073
63MP0000604_amyloidosis1.20169880
64MP0003646_muscle_fatigue1.19635501
65MP0009764_decreased_sensitivity_to1.18833709
66MP0004883_abnormal_blood_vessel1.16279521
67MP0000647_abnormal_sebaceous_gland1.12767401
68MP0005386_behavior/neurological_phenoty1.11728010
69MP0004924_abnormal_behavior1.11728010
70MP0001324_abnormal_eye_pigmentation1.10898347
71MP0001440_abnormal_grooming_behavior1.08838086
72MP0003119_abnormal_digestive_system1.08306186
73MP0005623_abnormal_meninges_morphology1.08219004
74MP0003303_peritoneal_inflammation1.07976555
75MP0009780_abnormal_chondrocyte_physiolo1.06205546
76MP0000470_abnormal_stomach_morphology1.04808535
77MP0003075_altered_response_to1.04698714
78MP0005503_abnormal_tendon_morphology1.04251004
79MP0000538_abnormal_urinary_bladder1.03654520
80MP0005646_abnormal_pituitary_gland1.03275511
81MP0009697_abnormal_copulation1.02654052
82MP0004272_abnormal_basement_membrane1.02081303
83MP0004215_abnormal_myocardial_fiber1.01933604
84MP0005195_abnormal_posterior_eye1.01569221
85MP0002876_abnormal_thyroid_physiology1.00739792
86MP0002064_seizures0.99299047
87MP0009250_abnormal_appendicular_skeleto0.98059336
88MP0001764_abnormal_homeostasis0.96603321
89MP0002971_abnormal_brown_adipose0.96417689
90MP0000230_abnormal_systemic_arterial0.94977400
91MP0003045_fibrosis0.94790699
92MP0002067_abnormal_sensory_capabilities0.94636389
93MP0003950_abnormal_plasma_membrane0.92823723
94MP0002166_altered_tumor_susceptibility0.92664710
95MP0000762_abnormal_tongue_morphology0.92375288
96MP0005379_endocrine/exocrine_gland_phen0.92283705
97MP0005187_abnormal_penis_morphology0.91647119
98MP0001664_abnormal_digestion0.89726413
99MP0000598_abnormal_liver_morphology0.88948836
100MP0005166_decreased_susceptibility_to0.88843262
101MP0009763_increased_sensitivity_to0.86651032
102MP0002938_white_spotting0.86376524
103MP0008872_abnormal_physiological_respon0.85001111
104MP0004185_abnormal_adipocyte_glucose0.84809456
105MP0008961_abnormal_basal_metabolism0.84734487
106MP0002734_abnormal_mechanical_nocicepti0.83879188
107MP0002272_abnormal_nervous_system0.83761085
108MP0010307_abnormal_tumor_latency0.83758321
109MP0005666_abnormal_adipose_tissue0.82141537
110MP0002928_abnormal_bile_duct0.81767392
111MP0002006_tumorigenesis0.81611443
112MP0005620_abnormal_muscle_contractility0.81412538
113MP0005334_abnormal_fat_pad0.81056427
114MP0001502_abnormal_circadian_rhythm0.80198179
115MP0001756_abnormal_urination0.79882486
116MP0003959_abnormal_lean_body0.79511766
117MP0005535_abnormal_body_temperature0.78127174
118MP0005310_abnormal_salivary_gland0.78087698
119MP0009643_abnormal_urine_homeostasis0.77996046
120MP0004885_abnormal_endolymph0.76209244
121MP0000462_abnormal_digestive_system0.75943951
122MP0003937_abnormal_limbs/digits/tail_de0.75494108
123MP0005248_abnormal_Harderian_gland0.75416849
124MP0003632_abnormal_nervous_system0.75168136
125MP0004134_abnormal_chest_morphology0.74842380
126MP0003755_abnormal_palate_morphology0.73029815
127MP0010352_gastrointestinal_tract_polyps0.72219028
128MP0006054_spinal_hemorrhage0.71232427
129MP0002572_abnormal_emotion/affect_behav0.71159366
130MP0002693_abnormal_pancreas_physiology0.69339007
131MP0004270_analgesia0.67848348
132MP0009115_abnormal_fat_cell0.67782832
133MP0001486_abnormal_startle_reflex0.67592914
134MP0003656_abnormal_erythrocyte_physiolo0.67294254
135MP0004742_abnormal_vestibular_system0.66432959
136MP0003633_abnormal_nervous_system0.66427091
137MP0003091_abnormal_cell_migration0.65841577
138MP0002078_abnormal_glucose_homeostasis0.65724388
139MP0005389_reproductive_system_phenotype0.65606243
140MP0005391_vision/eye_phenotype0.65561629
141MP0003724_increased_susceptibility_to0.65425406
142MP0000249_abnormal_blood_vessel0.65077440
143MP0002063_abnormal_learning/memory/cond0.64621820
144MP0002168_other_aberrant_phenotype0.64453428
145MP0001661_extended_life_span0.64417843
146MP0005448_abnormal_energy_balance0.63543945
147MP0008469_abnormal_protein_level0.63144879
148MP0000383_abnormal_hair_follicle0.63134083
149MP0006072_abnormal_retinal_apoptosis0.62379167
150MP0005647_abnormal_sex_gland0.62223569
151MP0003329_amyloid_beta_deposits0.61929540
152MP0005464_abnormal_platelet_physiology0.61514456
153MP0000767_abnormal_smooth_muscle0.61215251
154MP0008874_decreased_physiological_sensi0.60925486
155MP0004264_abnormal_extraembryonic_tissu0.60614989
156MP0002332_abnormal_exercise_endurance0.60062427
157MP0002229_neurodegeneration0.59981830
158MP0009765_abnormal_xenobiotic_induced0.58996537
159MP0009384_cardiac_valve_regurgitation0.58096380
160MP0003943_abnormal_hepatobiliary_system0.57851650
161MP0005164_abnormal_response_to0.57400131
162MP0004782_abnormal_surfactant_physiolog0.57292531
163MP0005084_abnormal_gallbladder_morpholo0.56004601
164MP0005375_adipose_tissue_phenotype0.55683128
165MP0001915_intracranial_hemorrhage0.54012780
166MP0004947_skin_inflammation0.53956162
167MP0009642_abnormal_blood_homeostasis0.53699084
168MP0005376_homeostasis/metabolism_phenot0.53204635
169MP0003453_abnormal_keratinocyte_physiol0.53101316
170MP0002909_abnormal_adrenal_gland0.52295041
171MP0000465_gastrointestinal_hemorrhage0.52100600

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.64830928
2Intrahepatic cholestasis (HP:0001406)5.11865979
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.88355107
4Abnormality of alanine metabolism (HP:0010916)4.88355107
5Hyperalaninemia (HP:0003348)4.88355107
6Pigmentary retinal degeneration (HP:0001146)4.74632004
7Type II lissencephaly (HP:0007260)4.64703637
8Xanthomatosis (HP:0000991)4.54573471
9Complement deficiency (HP:0004431)4.50594918
10Cerebellar dysplasia (HP:0007033)4.44602218
11Hyperventilation (HP:0002883)4.37780485
12Large for gestational age (HP:0001520)4.36523941
13Hypobetalipoproteinemia (HP:0003563)4.31907505
14Abnormality of monocarboxylic acid metabolism (HP:0010996)4.15623016
15Pheochromocytoma (HP:0002666)4.15363077
16Abnormality of aromatic amino acid family metabolism (HP:0004338)4.09737189
17Hyperlipoproteinemia (HP:0010980)4.04961627
18Prolonged partial thromboplastin time (HP:0003645)3.87934841
19Congenital stationary night blindness (HP:0007642)3.86710759
20Abnormality of the pons (HP:0007361)3.83772707
21Chorioretinal atrophy (HP:0000533)3.83234127
22Epidermoid cyst (HP:0200040)3.71007426
23Central scotoma (HP:0000603)3.46231182
24Neuroendocrine neoplasm (HP:0100634)3.45823308
25Bony spicule pigmentary retinopathy (HP:0007737)3.45750562
26Buphthalmos (HP:0000557)3.44576468
27Hypolipoproteinemia (HP:0010981)3.43177167
28Long nose (HP:0003189)3.33355916
29Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.31337643
30* Abnormality of the common coagulation pathway (HP:0010990)3.23329130
31Joint hemorrhage (HP:0005261)3.14633054
32Hypoalphalipoproteinemia (HP:0003233)3.13940823
33Hypochromic microcytic anemia (HP:0004840)3.08294303
34Esophageal varix (HP:0002040)3.08115937
35Hypercholesterolemia (HP:0003124)3.06014032
36Hematochezia (HP:0002573)3.03680321
37Myocardial infarction (HP:0001658)3.01379946
38Abnormality of complement system (HP:0005339)2.97942017
39Hypoglycemic coma (HP:0001325)2.95933708
40Dyschromatopsia (HP:0007641)2.93330033
41Abnormality of macular pigmentation (HP:0008002)2.93067935
42Papillary thyroid carcinoma (HP:0002895)2.91957651
43Conjunctival hamartoma (HP:0100780)2.90875562
44Abnormality of glutamine family amino acid metabolism (HP:0010902)2.90330865
45Lissencephaly (HP:0001339)2.90025789
46Abnormality of the vitreous humor (HP:0004327)2.89992874
47Hyperammonemia (HP:0001987)2.86241894
48Scotoma (HP:0000575)2.84916186
49Pancreatic cysts (HP:0001737)2.83224130
50Furrowed tongue (HP:0000221)2.78893823
51Meningioma (HP:0002858)2.78762929
52Duplicated collecting system (HP:0000081)2.77243477
53Fat malabsorption (HP:0002630)2.76534268
54Hypoplasia of the pons (HP:0012110)2.75895136
55Concave nail (HP:0001598)2.75837048
56Ketosis (HP:0001946)2.71414982
57Stomach cancer (HP:0012126)2.70461006
58Bone cyst (HP:0012062)2.69151939
59Abnormality of the intrinsic pathway (HP:0010989)2.68842736
60Fair hair (HP:0002286)2.67907343
61Prominent supraorbital ridges (HP:0000336)2.63638530
62Hypoplastic ischia (HP:0003175)2.63336556
63Congenital, generalized hypertrichosis (HP:0004540)2.62494652
64Cone-rod dystrophy (HP:0000548)2.60790277
65Hepatocellular carcinoma (HP:0001402)2.59907930
66Conjugated hyperbilirubinemia (HP:0002908)2.58479336
67Skin nodule (HP:0200036)2.56602114
68Abnormality of the ischium (HP:0003174)2.56301881
69Abnormality of the phalanges of the 2nd finger (HP:0009541)2.56018393
70Polydipsia (HP:0001959)2.55580647
71Abnormal drinking behavior (HP:0030082)2.55580647
72Absent rod-and cone-mediated responses on ERG (HP:0007688)2.50553394
73Recurrent gram-negative bacterial infections (HP:0005420)2.50543059
74Abolished electroretinogram (ERG) (HP:0000550)2.46540662
75Abnormality of the renal medulla (HP:0100957)2.46123733
76Abnormality of the renal collecting system (HP:0004742)2.45751008
77Hamartoma of the eye (HP:0010568)2.45256406
78Acanthocytosis (HP:0001927)2.42533585
79Macular degeneration (HP:0000608)2.40480707
80Abnormality of sulfur amino acid metabolism (HP:0004339)2.38898253
81Decreased circulating renin level (HP:0003351)2.38275953
82Pancreatic fibrosis (HP:0100732)2.37587222
83Spastic diplegia (HP:0001264)2.33741617
84Short hallux (HP:0010109)2.33083795
85Protruding tongue (HP:0010808)2.33025809
86Tubular atrophy (HP:0000092)2.32949029
87Macroorchidism (HP:0000053)2.32873896
88True hermaphroditism (HP:0010459)2.32733781
89Generalized hypopigmentation of hair (HP:0011358)2.30867987
90Abnormal rod and cone electroretinograms (HP:0008323)2.29784492
91Hemiparesis (HP:0001269)2.29208465
92Retinal dysplasia (HP:0007973)2.27433332
93Spontaneous abortion (HP:0005268)2.27063595
94Spontaneous hematomas (HP:0007420)2.26095975
95Polycythemia (HP:0001901)2.25890575
96Hyperglycinemia (HP:0002154)2.21318140
97Glomerulonephritis (HP:0000099)2.19399546
98Non-midline cleft lip (HP:0100335)2.19028099
99Abnormality of the nasal septum (HP:0000419)2.18109732
100Vitreoretinal degeneration (HP:0000655)2.17567925
101Mitral stenosis (HP:0001718)2.16809280
102Hypoglycemic seizures (HP:0002173)2.16200900
103Hemiplegia (HP:0002301)2.14478224
104Nephronophthisis (HP:0000090)2.14243326
105Systemic lupus erythematosus (HP:0002725)2.13501844
106Hemorrhage of the eye (HP:0011885)2.13486833
107Amyloidosis (HP:0011034)2.11185689
108Aplasia/Hypoplasia of the hallux (HP:0008362)2.10395029
109Thyroid carcinoma (HP:0002890)2.09884511
110Abnormality of midbrain morphology (HP:0002418)2.09509636
111Molar tooth sign on MRI (HP:0002419)2.09509636
112Abnormality of glycine metabolism (HP:0010895)2.08144052
113Abnormality of serine family amino acid metabolism (HP:0010894)2.08144052
114Hemangiomatosis (HP:0007461)2.06836723
115Visceral angiomatosis (HP:0100761)2.06417831
116Limb dystonia (HP:0002451)2.06190298
117Abnormality of aspartate family amino acid metabolism (HP:0010899)2.04782088
118Hamartoma (HP:0010566)2.03907636
119Subacute progressive viral hepatitis (HP:0006572)2.03893683
120Febrile seizures (HP:0002373)2.01375844
121Renal tubular acidosis (HP:0001947)2.01191937
122Lymphangioma (HP:0100764)1.99501784
123Posterior subcapsular cataract (HP:0007787)1.99409287
124Hyperkalemia (HP:0002153)1.98199712
125Thrombophlebitis (HP:0004418)1.97570535
126Gingival bleeding (HP:0000225)1.97356090
127Gaze-evoked nystagmus (HP:0000640)1.96997321
128Anterior segment dysgenesis (HP:0007700)1.95915967
129Subcapsular cataract (HP:0000523)1.95207708
130Macroglossia (HP:0000158)1.94516925
131Abnormality of the renal cortex (HP:0011035)1.93294036
132Abnormality of the 2nd finger (HP:0004100)1.92995228
133Depressed nasal tip (HP:0000437)1.92747651
134Pulmonary embolism (HP:0002204)1.92667407
135Partial agenesis of the corpus callosum (HP:0001338)1.92451738
136Widely spaced teeth (HP:0000687)1.92451413
137Overgrowth (HP:0001548)1.91062948
138Nephritis (HP:0000123)1.90874717
139Ketoacidosis (HP:0001993)1.90722641
140Hyperglycinuria (HP:0003108)1.90356400
141Conjunctival telangiectasia (HP:0000524)1.89456965
142Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.88135369
143Abnormality of purine metabolism (HP:0004352)1.87499866
144Polyuria (HP:0000103)1.85083272
145Retinal atrophy (HP:0001105)1.83148122
146Exotropia (HP:0000577)1.83120427
147Sensorimotor neuropathy (HP:0007141)1.82876355
148Abnormality of the parietal bone (HP:0002696)1.82655577
149Goiter (HP:0000853)1.81776936
150Vascular calcification (HP:0004934)1.81588348
151Broad-based gait (HP:0002136)1.81466374
152Abnormality of methionine metabolism (HP:0010901)1.80734941
153Decreased central vision (HP:0007663)1.80376098
154Intention tremor (HP:0002080)1.80317447
155Abnormal biliary tract morphology (HP:0012440)1.80119039
156Mesangial abnormality (HP:0001966)1.79849117
157Vertebral arch anomaly (HP:0008438)1.79483844
158Progressive visual loss (HP:0000529)1.79000099
159Increased CSF protein (HP:0002922)1.77324123
160Neoplasm of the peripheral nervous system (HP:0100007)1.76298242
161Type II diabetes mellitus (HP:0005978)1.75973683
162Amelogenesis imperfecta (HP:0000705)1.74971265
163Cardiovascular calcification (HP:0011915)1.74935753
164Poor head control (HP:0002421)1.74380415
165Hypomagnesemia (HP:0002917)1.74024559
166Steatorrhea (HP:0002570)1.72539827
167Hyperbilirubinemia (HP:0002904)1.72382101
168Abnormality of nucleobase metabolism (HP:0010932)1.71783324
169Poikilocytosis (HP:0004447)1.71674202
170Focal segmental glomerulosclerosis (HP:0000097)1.71092462
171Absent/shortened dynein arms (HP:0200106)1.70998798
172Dynein arm defect of respiratory motile cilia (HP:0012255)1.70998798
173Severe muscular hypotonia (HP:0006829)1.70591457
174Hypoplastic nipples (HP:0002557)1.69315272
175Clumsiness (HP:0002312)1.67530999
176Tachypnea (HP:0002789)1.67375757
177Stroke (HP:0001297)1.67226864
178Mitral valve prolapse (HP:0001634)1.65954797
179Rib fusion (HP:0000902)1.65673867
180Progressive inability to walk (HP:0002505)1.65230694
181Turricephaly (HP:0000262)1.65088324
182Abnormal pancreas size (HP:0012094)1.64903260
183Glomerulosclerosis (HP:0000096)1.64588116
184Tetraplegia (HP:0002445)1.64006504
185Hoarse voice (HP:0001609)1.63847096
186Autoimmune thrombocytopenia (HP:0001973)1.63284791
187Upper motor neuron abnormality (HP:0002127)1.62785749
188Attenuation of retinal blood vessels (HP:0007843)1.62202825
189Cerebral hemorrhage (HP:0001342)1.62092053
190Neoplasm of the thyroid gland (HP:0100031)1.59550666
191Neoplasm of the adrenal gland (HP:0100631)1.59315785
192Inability to walk (HP:0002540)1.58100442

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.10266969
2CASK3.07704282
3FGFR23.07157633
4ACVR1B2.95810242
5FGFR42.88648733
6TIE12.85726627
7WNK42.49712135
8LATS12.44928341
9SIK12.35610875
10RIPK12.34274965
11STK392.17865138
12GRK12.14218847
13PTK62.08122460
14FGFR32.02086410
15CAMK1G1.98225096
16ERN11.97074909
17MKNK21.96169511
18CAMK1D1.96039047
19YES11.91443606
20TGFBR21.89914080
21PDGFRA1.88812467
22ZAK1.87224893
23STK38L1.85110611
24BMPR1B1.84721413
25ADRBK21.80818728
26NTRK31.71088569
27PKN21.70752062
28JAK11.68182353
29MAP3K101.62239199
30MAP3K121.60921107
31PNCK1.59990703
32TRIB31.50215039
33MAP2K41.49181517
34TAOK31.44710835
35EPHB11.43433316
36INSRR1.43038259
37OXSR11.43026446
38CAMKK21.39896211
39TNIK1.39384046
40RIPK41.38159345
41MAP3K21.36428167
42AKT31.36392751
43RET1.36082171
44TYK21.32083370
45WNK31.26726275
46TAF11.24392323
47SIK21.22974683
48MUSK1.21828093
49PIK3CA1.21445015
50PDGFRB1.19901052
51JAK21.19499449
52CDK61.18490855
53SCYL21.17058622
54TRPM71.16181872
55MAP3K131.11872123
56MARK11.11496290
57MAP3K71.11153279
58CHUK1.10911564
59TYRO31.08436332
60DMPK1.08307518
61NLK1.04269615
62ERBB21.01216954
63PRKCH1.00950635
64KDR0.99967007
65KSR10.98934580
66TGFBR10.98263457
67MAP3K140.97968712
68SGK30.94456433
69DAPK20.92668564
70PTK2B0.92043169
71STK240.91828326
72ADRBK10.87389380
73PRKCE0.87281916
74MAPK150.85149579
75MAPK130.81858252
76ERBB40.81547744
77FER0.79437474
78KSR20.79200736
79PHKG20.78437838
80PHKG10.78437838
81TLK10.78432722
82WNK10.77518219
83NEK90.77317474
84PRKAA20.77273665
85PDK10.76967277
86PDPK10.76455052
87MST1R0.76062552
88NEK60.75723016
89CDK120.72449868
90JAK30.71954810
91STK30.71745929
92CSK0.71481440
93EGFR0.70474955
94IRAK30.68206055
95FGFR10.67687213
96MAP3K40.67236046
97OBSCN0.67118490
98PINK10.66986916
99BMX0.66278229
100BRSK20.66104453
101CAMKK10.65624197
102GSK3A0.65231942
103NUAK10.64436443
104MKNK10.64401633
105CSNK1A1L0.63979439
106NTRK10.63792067
107MAPK120.62773184
108FLT30.62529395
109PRKD10.61278279
110LMTK20.60792549
111TBK10.59986471
112PAK20.59874332
113MAPK110.59609271
114PAK30.58988146
115SGK20.58930247
116CSF1R0.58610109
117MAPK70.57191447
118ERBB30.57097072
119STK380.57020772
120ITK0.56861913
121PTK20.55534451
122HIPK20.54824369
123STK110.54338570
124PRKCZ0.54123280
125ABL10.53825429
126IRAK10.53579033
127BCKDK0.53514148
128CSNK1G20.53127854
129IGF1R0.52206454
130PRKCQ0.51320150
131MAP2K10.51270277
132RPS6KA60.50861019
133PIM10.50838694
134MARK30.50494480
135STK100.50488839
136CAMK2A0.48847805
137FYN0.48531461
138LRRK20.47749866
139INSR0.47549650
140IKBKB0.47496418
141PRKACG0.47468624
142MAP2K60.47412834
143SGK10.46899260
144MAP3K10.46799315
145ROCK10.45006443
146EPHB20.44958872
147PRKAA10.44533173
148CSNK1G10.44315901
149NTRK20.44169115
150PAK60.43246003
151MAP3K90.43012550
152CSNK1D0.42793064
153MET0.42557919
154EPHA30.41892704
155MTOR0.41892680
156DYRK1B0.41490584
157SGK2230.40277744
158SGK4940.40277744
159PLK20.40023264
160RPS6KA20.36036669
161MELK0.35731948
162PRKG10.34091665
163FGR0.32642903

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.12009809
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.53959345
3Phototransduction_Homo sapiens_hsa047443.00990093
4Arginine biosynthesis_Homo sapiens_hsa002202.98184519
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.78946924
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.44409739
7Complement and coagulation cascades_Homo sapiens_hsa046102.40911071
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.40547517
9Linoleic acid metabolism_Homo sapiens_hsa005912.17736540
10Caffeine metabolism_Homo sapiens_hsa002322.11370345
11Tryptophan metabolism_Homo sapiens_hsa003802.03500494
12Fatty acid degradation_Homo sapiens_hsa000712.00658069
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.98495636
14Bile secretion_Homo sapiens_hsa049761.82230195
15Staphylococcus aureus infection_Homo sapiens_hsa051501.77440924
16PPAR signaling pathway_Homo sapiens_hsa033201.77172003
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.73218483
18Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.67943016
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67146918
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.56027036
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.52637102
22Butanoate metabolism_Homo sapiens_hsa006501.48424855
23Mineral absorption_Homo sapiens_hsa049781.46612970
24ABC transporters_Homo sapiens_hsa020101.46439408
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45800737
26Fatty acid metabolism_Homo sapiens_hsa012121.44165655
27Long-term depression_Homo sapiens_hsa047301.39883199
28Ether lipid metabolism_Homo sapiens_hsa005651.37006686
29Histidine metabolism_Homo sapiens_hsa003401.34052533
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.30875333
31Peroxisome_Homo sapiens_hsa041461.30282142
32Insulin secretion_Homo sapiens_hsa049111.29617322
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29521955
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28413007
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25466820
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25028360
37Propanoate metabolism_Homo sapiens_hsa006401.22922060
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20855652
39Nicotine addiction_Homo sapiens_hsa050331.19813508
40Retinol metabolism_Homo sapiens_hsa008301.14712823
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14228703
42beta-Alanine metabolism_Homo sapiens_hsa004101.13046214
43Morphine addiction_Homo sapiens_hsa050321.12734926
44Vascular smooth muscle contraction_Homo sapiens_hsa042701.10434148
45Circadian rhythm_Homo sapiens_hsa047101.09172715
46Lysine degradation_Homo sapiens_hsa003101.08189526
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.06524085
48Ovarian steroidogenesis_Homo sapiens_hsa049131.03974872
49Serotonergic synapse_Homo sapiens_hsa047261.03737688
50Fat digestion and absorption_Homo sapiens_hsa049751.00807937
51Chemical carcinogenesis_Homo sapiens_hsa052040.97294918
52cAMP signaling pathway_Homo sapiens_hsa040240.96958234
53Calcium signaling pathway_Homo sapiens_hsa040200.96302298
54Protein digestion and absorption_Homo sapiens_hsa049740.96231912
55Sulfur relay system_Homo sapiens_hsa041220.94347029
56Starch and sucrose metabolism_Homo sapiens_hsa005000.93076850
57Phenylalanine metabolism_Homo sapiens_hsa003600.90280740
58ECM-receptor interaction_Homo sapiens_hsa045120.87303986
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87076607
60Cocaine addiction_Homo sapiens_hsa050300.86262479
61Insulin resistance_Homo sapiens_hsa049310.85856263
62Oxytocin signaling pathway_Homo sapiens_hsa049210.85103474
63Sulfur metabolism_Homo sapiens_hsa009200.83895616
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83674582
65Fatty acid biosynthesis_Homo sapiens_hsa000610.82083407
66Pancreatic secretion_Homo sapiens_hsa049720.80445565
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79488030
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77421320
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77035715
70TNF signaling pathway_Homo sapiens_hsa046680.76708166
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75643001
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75515304
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.74999418
74Tight junction_Homo sapiens_hsa045300.74966625
75Glycerolipid metabolism_Homo sapiens_hsa005610.73579661
76TGF-beta signaling pathway_Homo sapiens_hsa043500.71284716
77Tyrosine metabolism_Homo sapiens_hsa003500.70714795
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70169530
79Selenocompound metabolism_Homo sapiens_hsa004500.68351628
80Dorso-ventral axis formation_Homo sapiens_hsa043200.67782598
81Amphetamine addiction_Homo sapiens_hsa050310.67533323
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.66886530
83Prolactin signaling pathway_Homo sapiens_hsa049170.66080899
84Dopaminergic synapse_Homo sapiens_hsa047280.66045750
85FoxO signaling pathway_Homo sapiens_hsa040680.65733950
86ErbB signaling pathway_Homo sapiens_hsa040120.64524561
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62873100
88Taste transduction_Homo sapiens_hsa047420.61665788
89GnRH signaling pathway_Homo sapiens_hsa049120.61534369
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60481329
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59868873
92MAPK signaling pathway_Homo sapiens_hsa040100.59759544
93Type II diabetes mellitus_Homo sapiens_hsa049300.59295180
94Vitamin digestion and absorption_Homo sapiens_hsa049770.58551511
95Olfactory transduction_Homo sapiens_hsa047400.57062236
96Basal transcription factors_Homo sapiens_hsa030220.55899774
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54945117
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54252043
99Fatty acid elongation_Homo sapiens_hsa000620.54071782
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53156945
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52578413
102Estrogen signaling pathway_Homo sapiens_hsa049150.52135802
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50562968
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.49634448
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48087139
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47139734
107* Small cell lung cancer_Homo sapiens_hsa052220.46362226
108GABAergic synapse_Homo sapiens_hsa047270.45857799
109Ras signaling pathway_Homo sapiens_hsa040140.45663784
110Pyruvate metabolism_Homo sapiens_hsa006200.44950413
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44487553
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43823055
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41736489
114Prion diseases_Homo sapiens_hsa050200.40916501
115Amoebiasis_Homo sapiens_hsa051460.38699151
116mTOR signaling pathway_Homo sapiens_hsa041500.36958693
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35859810
118AMPK signaling pathway_Homo sapiens_hsa041520.35023346
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34964554
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.33565893
121Insulin signaling pathway_Homo sapiens_hsa049100.32405416
122Proteoglycans in cancer_Homo sapiens_hsa052050.31859661
123Biosynthesis of amino acids_Homo sapiens_hsa012300.31573150
124Carbon metabolism_Homo sapiens_hsa012000.30938772
125Glioma_Homo sapiens_hsa052140.30639991
126Glucagon signaling pathway_Homo sapiens_hsa049220.30032860
127Renin secretion_Homo sapiens_hsa049240.29634496
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29248919
129Adherens junction_Homo sapiens_hsa045200.29240323
130Aldosterone synthesis and secretion_Homo sapiens_hsa049250.29015890
131Platelet activation_Homo sapiens_hsa046110.28492955
132Thyroid hormone synthesis_Homo sapiens_hsa049180.26911462
133African trypanosomiasis_Homo sapiens_hsa051430.26900312
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.26768474
135Glutamatergic synapse_Homo sapiens_hsa047240.26676369
136Hepatitis C_Homo sapiens_hsa051600.26116174
137Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25374506
138Chemokine signaling pathway_Homo sapiens_hsa040620.25372487
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25176303
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24433493
141Salivary secretion_Homo sapiens_hsa049700.23958613
142* Focal adhesion_Homo sapiens_hsa045100.23430267
143Gastric acid secretion_Homo sapiens_hsa049710.23255917
144Non-small cell lung cancer_Homo sapiens_hsa052230.21304691
145B cell receptor signaling pathway_Homo sapiens_hsa046620.21152005
146Choline metabolism in cancer_Homo sapiens_hsa052310.20707335
147Cholinergic synapse_Homo sapiens_hsa047250.20634891
148Inositol phosphate metabolism_Homo sapiens_hsa005620.20477848
149Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19770101
150Steroid biosynthesis_Homo sapiens_hsa001000.19726058
151Central carbon metabolism in cancer_Homo sapiens_hsa052300.19343013
152Renal cell carcinoma_Homo sapiens_hsa052110.18550972
153Glycerophospholipid metabolism_Homo sapiens_hsa005640.18297119
154Osteoclast differentiation_Homo sapiens_hsa043800.18078100
155Circadian entrainment_Homo sapiens_hsa047130.17852513
156Phospholipase D signaling pathway_Homo sapiens_hsa040720.17614038

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