XCR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intracellular pH reduction (GO:0051452)7.67469144
2regulation of phospholipase A2 activity (GO:0032429)7.57830087
3glycosphingolipid catabolic process (GO:0046479)6.73484881
4sphingolipid catabolic process (GO:0030149)6.59837151
5regulation of B cell receptor signaling pathway (GO:0050855)6.50303449
6pinocytosis (GO:0006907)6.49104350
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.44310851
8positive regulation by organism of defense response of other organism involved in symbiotic interact6.44310851
9modulation by symbiont of host immune response (GO:0052553)6.44310851
10positive regulation by symbiont of host defense response (GO:0052509)6.44310851
11modulation by symbiont of host defense response (GO:0052031)6.44310851
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.44310851
13pH reduction (GO:0045851)6.16591777
14regulation of dendritic cell antigen processing and presentation (GO:0002604)6.15552398
15glycolipid catabolic process (GO:0019377)6.02701488
16microglial cell activation (GO:0001774)5.99545623
17membrane lipid catabolic process (GO:0046466)5.91687243
18ceramide catabolic process (GO:0046514)5.90430459
19cellular response to exogenous dsRNA (GO:0071360)5.74404254
20positive regulation of mast cell degranulation (GO:0043306)5.41128153
21positive regulation of mast cell activation involved in immune response (GO:0033008)5.41128153
22positive regulation of antigen processing and presentation (GO:0002579)5.31496753
23oligosaccharide catabolic process (GO:0009313)4.97907031
24positive regulation of mast cell activation (GO:0033005)4.97348855
25respiratory burst (GO:0045730)4.86796725
26positive regulation of chemokine biosynthetic process (GO:0045080)4.86695816
27T cell costimulation (GO:0031295)4.74445962
28lymphocyte costimulation (GO:0031294)4.69212024
29regulation of antigen processing and presentation (GO:0002577)4.68124612
30positive regulation of interferon-alpha production (GO:0032727)4.66371337
31histamine transport (GO:0051608)4.62353562
32positive regulation of monocyte chemotaxis (GO:0090026)4.57192029
33response to peptidoglycan (GO:0032494)4.51661972
34membrane raft organization (GO:0031579)4.49188655
35response to host immune response (GO:0052572)4.41964085
36response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.41964085
37adenosine receptor signaling pathway (GO:0001973)4.40414890
38regulation of interferon-alpha production (GO:0032647)4.36752234
39grooming behavior (GO:0007625)4.31509591
40righting reflex (GO:0060013)4.29842098
41intraciliary transport (GO:0042073)4.25974377
42regulation of interferon-beta biosynthetic process (GO:0045357)4.23323681
43macrophage activation (GO:0042116)3.99414673
44macrophage activation involved in immune response (GO:0002281)3.99322482
45positive regulation of interleukin-12 production (GO:0032735)3.95405944
46regulation of intracellular pH (GO:0051453)3.92723414
47positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.91586248
48positive regulation of T cell differentiation in thymus (GO:0033089)3.89041703
49regulation of lymphocyte migration (GO:2000401)3.88541615
50regulation of chemokine biosynthetic process (GO:0045073)3.87071134
51positive regulation of T cell mediated cytotoxicity (GO:0001916)3.85641612
52response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.84176574
53response to host (GO:0075136)3.84176574
54response to host defenses (GO:0052200)3.84176574
55superoxide anion generation (GO:0042554)3.76691309
56cellular response to interferon-beta (GO:0035458)3.72620834
57cellular protein catabolic process (GO:0044257)3.68784924
58antigen processing and presentation of endogenous antigen (GO:0019883)3.68319989
59behavioral response to ethanol (GO:0048149)3.67116856
60positive regulation of T cell migration (GO:2000406)3.66858154
61positive regulation of cellular amide metabolic process (GO:0034250)3.66035762
62defense response to protozoan (GO:0042832)3.64971863
63tryptophan catabolic process (GO:0006569)3.63289758
64indole-containing compound catabolic process (GO:0042436)3.63289758
65indolalkylamine catabolic process (GO:0046218)3.63289758
66negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.58029381
67regulation of cellular pH (GO:0030641)3.57713659
68reflex (GO:0060004)3.53764528
69regulation of T cell tolerance induction (GO:0002664)3.52029275
70production of molecular mediator involved in inflammatory response (GO:0002532)3.51946120
71negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.49728957
72import into cell (GO:0098657)3.48207750
73pantothenate metabolic process (GO:0015939)3.44910612
74positive regulation of leukocyte degranulation (GO:0043302)3.43693358
75regulation of calcium-mediated signaling (GO:0050848)3.39469044
76positive regulation of toll-like receptor signaling pathway (GO:0034123)3.38635753
77positive regulation of calcium-mediated signaling (GO:0050850)3.37592186
78detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.37543944
79GTP biosynthetic process (GO:0006183)3.37196165
80regulation of T cell mediated cytotoxicity (GO:0001914)3.36816474
81regulation of monocyte chemotaxis (GO:0090025)3.36339138
82iron ion import (GO:0097286)3.35643167
83neutrophil activation involved in immune response (GO:0002283)3.34898846
84positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.34006542
85positive regulation of prostaglandin secretion (GO:0032308)3.33417329
86Rac protein signal transduction (GO:0016601)3.32747685
87negative regulation of alpha-beta T cell activation (GO:0046636)3.31779006
88cytokine biosynthetic process (GO:0042089)3.31713347
89positive regulation of T-helper 1 type immune response (GO:0002827)3.30274525
90activated T cell proliferation (GO:0050798)3.27038842
91apoptotic DNA fragmentation (GO:0006309)3.26083578
92positive regulation of lymphocyte migration (GO:2000403)3.23491199
93negative regulation of T cell receptor signaling pathway (GO:0050860)3.22293106
94thrombin receptor signaling pathway (GO:0070493)3.21339196
95positive regulation of interleukin-17 production (GO:0032740)3.15355605
96regulation of T cell migration (GO:2000404)3.15262771
97protein K11-linked deubiquitination (GO:0035871)3.14934659
98kynurenine metabolic process (GO:0070189)3.14123331
99positive regulation of type 2 immune response (GO:0002830)3.11395590
100positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.10725514
101multicellular organism reproduction (GO:0032504)3.09988355
102tryptophan metabolic process (GO:0006568)3.09125203
103B cell mediated immunity (GO:0019724)3.08967207
104phagocytosis, engulfment (GO:0006911)3.08720310
105regulation of acrosome reaction (GO:0060046)3.08378897
106developmental programmed cell death (GO:0010623)3.06048701
107interferon-gamma-mediated signaling pathway (GO:0060333)3.06042707
108immunoglobulin mediated immune response (GO:0016064)3.05160299
109response to protozoan (GO:0001562)3.04967893
110germinal center formation (GO:0002467)3.03753898
111T cell receptor signaling pathway (GO:0050852)3.02295073
112I-kappaB phosphorylation (GO:0007252)3.00734146
113azole transport (GO:0045117)2.99822942
114negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.99325638
115response to muramyl dipeptide (GO:0032495)2.99069919
116CTP metabolic process (GO:0046036)2.97123333
117CTP biosynthetic process (GO:0006241)2.97123333
118Golgi to endosome transport (GO:0006895)2.96003196
119actin nucleation (GO:0045010)2.95984081
120regulation of tolerance induction (GO:0002643)2.95824266
121positive regulation of megakaryocyte differentiation (GO:0045654)2.95128733
122regulation of alpha-beta T cell proliferation (GO:0046640)2.92903025
123early endosome to late endosome transport (GO:0045022)2.92595419
124regulation of interleukin-12 production (GO:0032655)2.91077826
125negative regulation of cAMP-mediated signaling (GO:0043951)2.90206728
126rRNA catabolic process (GO:0016075)2.89923377
127positive regulation of heat generation (GO:0031652)2.88390091
128regulation of activation of Janus kinase activity (GO:0010533)2.88369520
129regulation of fever generation (GO:0031620)2.88209656
130negative regulation of B cell proliferation (GO:0030889)2.86868206
131epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.86352266
132neutrophil activation (GO:0042119)2.86221759
133ganglioside metabolic process (GO:0001573)2.86163707
134glycoside metabolic process (GO:0016137)2.85838450
135Arp2/3 complex-mediated actin nucleation (GO:0034314)2.85804602
136positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.84981235
137platelet dense granule organization (GO:0060155)2.84338500
138regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.83928074
139positive regulation of interleukin-6 production (GO:0032755)2.83515475
140response to pheromone (GO:0019236)2.81572000
141G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.80454601
142myeloid leukocyte activation (GO:0002274)2.79632033
143regulation of mast cell activation (GO:0033003)2.79534921
144positive regulation of T cell chemotaxis (GO:0010820)2.79418569
145regulation of T cell chemotaxis (GO:0010819)2.79418569
146histamine secretion (GO:0001821)2.79228951
147positive regulation of interferon-beta production (GO:0032728)2.77653113
148regulation of T cell receptor signaling pathway (GO:0050856)2.77594597
149negative regulation of mast cell activation (GO:0033004)2.76743541
150regulation of chronic inflammatory response (GO:0002676)2.76704292
151amine catabolic process (GO:0009310)2.74580402
152cellular biogenic amine catabolic process (GO:0042402)2.74580402
153indolalkylamine metabolic process (GO:0006586)2.73955497
154piRNA metabolic process (GO:0034587)2.73735576
155signal peptide processing (GO:0006465)2.72674763
156regulation of meiosis I (GO:0060631)2.72601851
157cellular response to interferon-gamma (GO:0071346)2.72348992
158cytokine metabolic process (GO:0042107)2.72075489
159regulation of heat generation (GO:0031650)2.71173116
160autophagic vacuole fusion (GO:0000046)2.70947921
161response to interferon-gamma (GO:0034341)2.70659759
162regulation of T-helper 2 cell differentiation (GO:0045628)2.70370646
163regulation of mast cell degranulation (GO:0043304)2.69739396
164regulation of prostaglandin secretion (GO:0032306)2.69639617
165detection of bacterium (GO:0016045)2.68719422
166myeloid cell activation involved in immune response (GO:0002275)2.68559000
167detection of other organism (GO:0098543)2.68432643
168G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.67438091
169purinergic receptor signaling pathway (GO:0035587)2.67241001
170interferon-gamma production (GO:0032609)2.67183455
171positive regulation of smooth muscle cell migration (GO:0014911)2.66921171
172positive regulation of interferon-gamma production (GO:0032729)2.66743334
173L-amino acid import (GO:0043092)2.66624969
174regulation of mast cell activation involved in immune response (GO:0033006)2.66165441
175C4-dicarboxylate transport (GO:0015740)2.64455478
176antigen receptor-mediated signaling pathway (GO:0050851)2.63937014
177positive regulation of glycoprotein biosynthetic process (GO:0010560)2.63251542
178phosphatidylserine acyl-chain remodeling (GO:0036150)2.63163531
179regulation of female gonad development (GO:2000194)2.62327902
180positive regulation of T cell activation (GO:0050870)2.61185245
181UTP biosynthetic process (GO:0006228)2.57297032
182tongue development (GO:0043586)2.56397270
183regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.55909904
184negative thymic T cell selection (GO:0045060)2.55326495
185positive regulation of T cell proliferation (GO:0042102)2.53524485
186negative T cell selection (GO:0043383)2.52302560

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_21731497_ChIP-ChIP_J774_Mouse6.07645404
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.59018495
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.44951755
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.20637044
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.11387760
6* IRF8_27001747_Chip-Seq_BMDM_Mouse3.59832292
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.17942087
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.03851268
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.00534019
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.65507127
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.62506738
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.52250753
13GBX2_23144817_ChIP-Seq_PC3_Human2.48859379
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.41384391
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.36940198
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.34025539
17VDR_22108803_ChIP-Seq_LS180_Human2.32112243
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.29721761
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.27120194
20IGF1R_20145208_ChIP-Seq_DFB_Human2.25973849
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.16426852
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01265615
23AR_21572438_ChIP-Seq_LNCaP_Human1.96461470
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.93300286
25* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.93295885
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.91711413
27CBP_20019798_ChIP-Seq_JUKART_Human1.91711413
28* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.90130381
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87666347
30BCAT_22108803_ChIP-Seq_LS180_Human1.87174742
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85844527
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.80254985
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.76867622
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75849809
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.75073507
36ZNF274_21170338_ChIP-Seq_K562_Hela1.73106198
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.67150631
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66370242
39EWS_26573619_Chip-Seq_HEK293_Human1.65592289
40E2F1_18555785_Chip-Seq_ESCs_Mouse1.61160557
41NANOG_19829295_ChIP-Seq_ESCs_Human1.61092159
42SOX2_19829295_ChIP-Seq_ESCs_Human1.61092159
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55093910
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54030667
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53141244
46STAT3_18555785_Chip-Seq_ESCs_Mouse1.52970275
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52081495
48ER_23166858_ChIP-Seq_MCF-7_Human1.50884715
49PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.50761306
50NMYC_18555785_Chip-Seq_ESCs_Mouse1.48388939
51VDR_24787735_ChIP-Seq_THP-1_Human1.48382757
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.48330866
53AR_20517297_ChIP-Seq_VCAP_Human1.47739437
54* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.46855372
55P53_22387025_ChIP-Seq_ESCs_Mouse1.46717799
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.45282485
57SUZ12_18555785_Chip-Seq_ESCs_Mouse1.44515218
58RUNX1_27457419_Chip-Seq_LIVER_Mouse1.43759055
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43139038
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.42508405
61P300_18555785_Chip-Seq_ESCs_Mouse1.41615172
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39825517
63CDX2_22108803_ChIP-Seq_LS180_Human1.38400240
64PU1_27457419_Chip-Seq_LIVER_Mouse1.37533098
65CMYC_18555785_Chip-Seq_ESCs_Mouse1.36704916
66PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36704509
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36601955
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36590651
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34700357
70TCF4_22108803_ChIP-Seq_LS180_Human1.33690286
71* GATA3_21878914_ChIP-Seq_MCF-7_Human1.33642774
72FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33059721
73MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33000029
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32423479
75EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.31863760
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31042544
77P300_19829295_ChIP-Seq_ESCs_Human1.30922575
78SMAD4_21741376_ChIP-Seq_EPCs_Human1.29883974
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29000228
80FUS_26573619_Chip-Seq_HEK293_Human1.28473890
81SMAD1_18555785_Chip-Seq_ESCs_Mouse1.28391154
82HTT_18923047_ChIP-ChIP_STHdh_Human1.28066541
83PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27415355
84PU_27001747_Chip-Seq_BMDM_Mouse1.26619058
85TCF4_23295773_ChIP-Seq_U87_Human1.25785996
86SOX2_18555785_Chip-Seq_ESCs_Mouse1.25690566
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25432071
88SPI1_23547873_ChIP-Seq_NB4_Human1.23664914
89KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23378501
90SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.22316121
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22308681
92ESRRB_18555785_Chip-Seq_ESCs_Mouse1.21585951
93OCT4_18555785_Chip-Seq_ESCs_Mouse1.20065403
94CTCF_18555785_Chip-Seq_ESCs_Mouse1.20041070
95CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19122096
96* RUNX_20019798_ChIP-Seq_JUKART_Human1.19019744
97FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18638448
98FOXA1_25329375_ChIP-Seq_VCAP_Human1.18638448
99PIAS1_25552417_ChIP-Seq_VCAP_Human1.18112272
100KLF4_18555785_Chip-Seq_ESCs_Mouse1.17219671
101EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17014964
102SPI1_23127762_ChIP-Seq_K562_Human1.16405243
103RUNX2_22187159_ChIP-Seq_PCA_Human1.14971125
104FOXH1_21741376_ChIP-Seq_EPCs_Human1.14561541
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14441670
106ZFX_18555785_Chip-Seq_ESCs_Mouse1.14338425
107EGR1_19032775_ChIP-ChIP_M12_Human1.14290103
108GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.14289745
109MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14132702
110CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.13875953
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.13402375
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12229431
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12013108
114* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11869368
115* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11339825
116SCL_19346495_ChIP-Seq_HPC-7_Human1.10968176
117HOXB7_26014856_ChIP-Seq_BT474_Human1.10511697
118MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09754237
119TAF15_26573619_Chip-Seq_HEK293_Human1.08473602
120FOXO3_23340844_ChIP-Seq_DLD1_Human1.07964294
121RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06279160
122MYB_26560356_Chip-Seq_TH2_Human1.05904645
123SMAD3_21741376_ChIP-Seq_EPCs_Human1.05809957
124* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.05588203
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05115951
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05115951
127CRX_20693478_ChIP-Seq_RETINA_Mouse1.05114339
128ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04933539
129CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04311778
130PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.03655865
131GATA3_27048872_Chip-Seq_THYMUS_Human1.03605826
132TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03525646
133SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03512417
134TP53_22573176_ChIP-Seq_HFKS_Human1.02849842
135GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02481595
136GATA6_21074721_ChIP-Seq_CACO-2_Human1.02389651
137BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02286535
138ETV1_20927104_ChIP-Seq_GIST48_Human1.02273291
139NCOR_22424771_ChIP-Seq_293T_Human1.02267815
140SMAD4_21799915_ChIP-Seq_A2780_Human1.01811211
141OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00414129
142* PRDM14_20953172_ChIP-Seq_ESCs_Human0.95625992
143GATA3_26560356_Chip-Seq_TH2_Human0.95372924
144UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95270252
145CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95205153
146* AR_25329375_ChIP-Seq_VCAP_Human0.93873777
147MYB_21317192_ChIP-Seq_ERMYB_Mouse0.93342063
148PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93174149
149PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92691290
150RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91801724
151BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91525812
152GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90346496
153SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.89750250
154TP63_19390658_ChIP-ChIP_HaCaT_Human0.89326950
155STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89308041
156FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.88861075
157EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88590411
158* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88371494
159EZH2_22144423_ChIP-Seq_EOC_Human0.84010631
160STAT3_23295773_ChIP-Seq_U87_Human0.82760439

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation7.97766155
2MP0006082_CNS_inflammation5.00421799
3MP0003136_yellow_coat_color3.64371898
4MP0002148_abnormal_hypersensitivity_rea3.63972273
5MP0005671_abnormal_response_to3.59118770
6MP0004147_increased_porphyrin_level3.53189451
7MP0009785_altered_susceptibility_to3.20261522
8MP0004510_myositis3.15173090
9MP0005377_hearing/vestibular/ear_phenot2.96305147
10MP0003878_abnormal_ear_physiology2.96305147
11MP0001790_abnormal_immune_system2.84749106
12MP0005387_immune_system_phenotype2.84749106
13MP0000372_irregular_coat_pigmentation2.79861256
14MP0002419_abnormal_innate_immunity2.68370437
15MP0005025_abnormal_response_to2.57505897
16MP0005000_abnormal_immune_tolerance2.57098388
17MP0000685_abnormal_immune_system2.54363406
18* MP0002452_abnormal_antigen_presenting2.48021486
19MP0005408_hypopigmentation2.41497051
20MP0003436_decreased_susceptibility_to2.41036678
21MP0001853_heart_inflammation2.25323684
22MP0001800_abnormal_humoral_immune2.22712174
23MP0002723_abnormal_immune_serum2.18402021
24MP0002090_abnormal_vision2.17621654
25* MP0001819_abnormal_immune_cell2.15255626
26MP0003724_increased_susceptibility_to2.10667121
27MP0001188_hyperpigmentation2.04888309
28MP0002420_abnormal_adaptive_immunity2.04166765
29MP0009046_muscle_twitch2.02486638
30MP0002006_tumorigenesis1.98564401
31MP0002876_abnormal_thyroid_physiology1.89515020
32MP0005464_abnormal_platelet_physiology1.87066148
33MP0003195_calcinosis1.84284183
34MP0005171_absent_coat_pigmentation1.82117612
35MP0003880_abnormal_central_pattern1.78940915
36MP0002163_abnormal_gland_morphology1.71984187
37MP0002166_altered_tumor_susceptibility1.71831950
38MP0002405_respiratory_system_inflammati1.70329057
39MP0009764_decreased_sensitivity_to1.69908929
40MP0009333_abnormal_splenocyte_physiolog1.67236602
41MP0006072_abnormal_retinal_apoptosis1.66994470
42MP0006292_abnormal_olfactory_placode1.63228910
43MP0002102_abnormal_ear_morphology1.59525562
44MP0002653_abnormal_ependyma_morphology1.56180805
45MP0003646_muscle_fatigue1.55295018
46MP0005360_urolithiasis1.54925019
47MP0003183_abnormal_peptide_metabolism1.52505502
48MP0005551_abnormal_eye_electrophysiolog1.45135492
49MP0001440_abnormal_grooming_behavior1.39065813
50MP0003718_maternal_effect1.37357323
51MP0000716_abnormal_immune_system1.36973708
52MP0003172_abnormal_lysosome_physiology1.34046446
53MP0005075_abnormal_melanosome_morpholog1.30680182
54MP0003303_peritoneal_inflammation1.28120171
55MP0001845_abnormal_inflammatory_respons1.26575950
56MP0001485_abnormal_pinna_reflex1.25576346
57MP0003252_abnormal_bile_duct1.24744083
58MP0005253_abnormal_eye_physiology1.24643960
59MP0003941_abnormal_skin_development1.24491643
60MP0010155_abnormal_intestine_physiology1.18984195
61MP0000681_abnormal_thyroid_gland1.16936794
62MP0004019_abnormal_vitamin_homeostasis1.15905443
63MP0005310_abnormal_salivary_gland1.15756329
64MP0000427_abnormal_hair_cycle1.14389249
65MP0008877_abnormal_DNA_methylation1.13880329
66MP0001873_stomach_inflammation1.13264288
67MP0005409_darkened_coat_color1.12065881
68MP0002398_abnormal_bone_marrow1.10630616
69MP0001986_abnormal_taste_sensitivity1.09913301
70MP0008469_abnormal_protein_level1.09142790
71MP0003879_abnormal_hair_cell1.08151964
72MP0000465_gastrointestinal_hemorrhage1.07373860
73MP0002277_abnormal_respiratory_mucosa1.05806475
74MP0004142_abnormal_muscle_tone1.05635114
75MP0005451_abnormal_body_composition1.02212296
76MP0000689_abnormal_spleen_morphology1.01783473
77MP0000371_diluted_coat_color1.01526246
78MP0001186_pigmentation_phenotype1.01246862
79MP0003075_altered_response_to1.00675152
80MP0005085_abnormal_gallbladder_physiolo0.99275540
81MP0008872_abnormal_physiological_respon0.98818228
82MP0002429_abnormal_blood_cell0.98131229
83MP0002736_abnormal_nociception_after0.96911675
84MP0002139_abnormal_hepatobiliary_system0.96528595
85MP0004782_abnormal_surfactant_physiolog0.96135931
86MP0005058_abnormal_lysosome_morphology0.91277324
87MP0002998_abnormal_bone_remodeling0.91086202
88MP0001984_abnormal_olfaction0.88092337
89MP0004043_abnormal_pH_regulation0.86973109
90MP0001756_abnormal_urination0.86177316
91MP0000343_altered_response_to0.86035577
92MP0001293_anophthalmia0.85629770
93MP0000383_abnormal_hair_follicle0.85397719
94MP0000015_abnormal_ear_pigmentation0.85310777
95MP0001533_abnormal_skeleton_physiology0.83782703
96MP0002098_abnormal_vibrissa_morphology0.83488663
97MP0002735_abnormal_chemical_nociception0.82291139
98MP0001324_abnormal_eye_pigmentation0.82094005
99MP0000631_abnormal_neuroendocrine_gland0.81321449
100MP0002837_dystrophic_cardiac_calcinosis0.79928865
101MP0008004_abnormal_stomach_pH0.79834265
102MP0001663_abnormal_digestive_system0.79526947
103MP0005670_abnormal_white_adipose0.78275344
104MP0005645_abnormal_hypothalamus_physiol0.78151808
105MP0005379_endocrine/exocrine_gland_phen0.78082409
106MP0000858_altered_metastatic_potential0.77763247
107MP0004484_altered_response_of0.77626242
108MP0002928_abnormal_bile_duct0.76823143
109MP0001919_abnormal_reproductive_system0.76294372
110MP0002722_abnormal_immune_system0.75837402
111MP0002272_abnormal_nervous_system0.74760013
112MP0008875_abnormal_xenobiotic_pharmacok0.74709449
113MP0003045_fibrosis0.74663708
114MP0001501_abnormal_sleep_pattern0.74657357
115MP0008260_abnormal_autophagy0.72356461
116MP0001666_abnormal_nutrient_absorption0.72167242
117MP0005195_abnormal_posterior_eye0.70843253
118MP0000026_abnormal_inner_ear0.70654845
119MP0002067_abnormal_sensory_capabilities0.69936966
120MP0005084_abnormal_gallbladder_morpholo0.68753696
121MP0010678_abnormal_skin_adnexa0.67991171
122MP0003448_altered_tumor_morphology0.67370731
123MP0009115_abnormal_fat_cell0.66622570
124MP0001119_abnormal_female_reproductive0.66456514
125MP0002138_abnormal_hepatobiliary_system0.65514065
126MP0005174_abnormal_tail_pigmentation0.65494435
127MP0002075_abnormal_coat/hair_pigmentati0.65394839
128MP0003943_abnormal_hepatobiliary_system0.65066973
129MP0002234_abnormal_pharynx_morphology0.64781242
130MP0005166_decreased_susceptibility_to0.63976934
131MP0003763_abnormal_thymus_physiology0.63049773
132MP0005397_hematopoietic_system_phenotyp0.61682766
133MP0001545_abnormal_hematopoietic_system0.61682766
134MP0002095_abnormal_skin_pigmentation0.61412788
135MP0004947_skin_inflammation0.58896026
136MP0002933_joint_inflammation0.57529180
137MP0000569_abnormal_digit_pigmentation0.55765301
138MP0010386_abnormal_urinary_bladder0.54514593
139MP0005595_abnormal_vascular_smooth0.53584619
140MP0002572_abnormal_emotion/affect_behav0.50459901
141MP0002693_abnormal_pancreas_physiology0.49744989
142MP0009697_abnormal_copulation0.48265947
143MP0002638_abnormal_pupillary_reflex0.47467777
144MP0000920_abnormal_myelination0.46900286
145MP0002064_seizures0.46606197
146MP0004381_abnormal_hair_follicle0.46246448
147MP0003866_abnormal_defecation0.45651080
148MP0005167_abnormal_blood-brain_barrier0.45014770
149MP0002938_white_spotting0.42905434

Predicted human phenotypes

RankGene SetZ-score
1Increased neuronal autofluorescent lipopigment (HP:0002074)9.48029957
2Increased cerebral lipofuscin (HP:0011813)8.25136023
3Absent/shortened dynein arms (HP:0200106)6.28854169
4Dynein arm defect of respiratory motile cilia (HP:0012255)6.28854169
5Loss of speech (HP:0002371)6.04264744
6Testicular atrophy (HP:0000029)5.61663836
7Chronic obstructive pulmonary disease (HP:0006510)5.58011592
8Obstructive lung disease (HP:0006536)5.58011592
9Abolished electroretinogram (ERG) (HP:0000550)5.54934271
10Cerebral palsy (HP:0100021)5.45039338
11Recurrent abscess formation (HP:0002722)5.04411777
12Abnormality of liposaccharide metabolism (HP:0010968)4.96332912
13Abnormality of glycosphingolipid metabolism (HP:0004343)4.96332912
14Abnormality of glycolipid metabolism (HP:0010969)4.96332912
15Decreased electroretinogram (ERG) amplitude (HP:0000654)4.75917380
16Recurrent bacterial skin infections (HP:0005406)4.37392893
17Eczematoid dermatitis (HP:0000976)4.29634408
18Chin dimple (HP:0010751)3.94127738
19Abnormal ciliary motility (HP:0012262)3.85080983
20Recurrent gram-negative bacterial infections (HP:0005420)3.59393572
21Poor head control (HP:0002421)3.56325094
22Abnormality of the pleura (HP:0002103)3.48448763
23Arthropathy (HP:0003040)3.41349866
24Abnormal respiratory motile cilium morphology (HP:0005938)3.40951521
25Abnormal respiratory epithelium morphology (HP:0012253)3.40951521
26Aplasia/Hypoplasia of the tibia (HP:0005772)3.35090067
27Meningitis (HP:0001287)3.33604372
28Hemoptysis (HP:0002105)3.29242890
29Acrocyanosis (HP:0001063)3.28769308
30Vasculitis (HP:0002633)3.23879665
31Mediastinal lymphadenopathy (HP:0100721)3.21065416
32Hypoproteinemia (HP:0003075)3.21018709
33Short tibia (HP:0005736)3.20047033
34Macular degeneration (HP:0000608)3.17539311
35Azoospermia (HP:0000027)3.13699519
36Progressive visual loss (HP:0000529)3.02210937
37Progressive microcephaly (HP:0000253)3.01700003
38Hydroxyprolinuria (HP:0003080)2.94665537
39Abnormality of proline metabolism (HP:0010907)2.94665537
40Retrobulbar optic neuritis (HP:0100654)2.93410115
41Optic neuritis (HP:0100653)2.93410115
42Recurrent sinusitis (HP:0011108)2.89483850
43Chronic otitis media (HP:0000389)2.86476151
44Increased IgM level (HP:0003496)2.82550184
45Ankyloglossia (HP:0010296)2.77454940
46Abnormality of glutamine family amino acid metabolism (HP:0010902)2.76030710
47Abnormality of the pericardium (HP:0001697)2.74292629
48Abnormality of B cell number (HP:0010975)2.69693589
49Recurrent skin infections (HP:0001581)2.64354594
50Pulmonary infiltrates (HP:0002113)2.64318498
51Abnormality of macrophages (HP:0004311)2.63563561
52Nephritis (HP:0000123)2.60382184
53Glomerulopathy (HP:0100820)2.59985979
54Xerostomia (HP:0000217)2.59790101
55Paralysis (HP:0003470)2.59399985
56Decreased circulating renin level (HP:0003351)2.58890366
57Abnormality of complement system (HP:0005339)2.58472973
58Chromosomal breakage induced by crosslinking agents (HP:0003221)2.57690298
59Abnormality of the prostate (HP:0008775)2.56703360
60Abnormal respiratory motile cilium physiology (HP:0012261)2.50588084
61Prolonged partial thromboplastin time (HP:0003645)2.46368491
62Recurrent bronchitis (HP:0002837)2.46188720
63Prostate neoplasm (HP:0100787)2.44994953
64Neoplasm of the colon (HP:0100273)2.43279320
65Gingivitis (HP:0000230)2.38129862
66Severe combined immunodeficiency (HP:0004430)2.37932071
67Myositis (HP:0100614)2.37062471
68Recurrent fungal infections (HP:0002841)2.36102210
69Pancreatic cysts (HP:0001737)2.34161717
70Orchitis (HP:0100796)2.33894100
71Thyroiditis (HP:0100646)2.32554787
72Fair hair (HP:0002286)2.31220441
73Reduced antithrombin III activity (HP:0001976)2.28757077
74Gangrene (HP:0100758)2.26006075
75Ureteral stenosis (HP:0000071)2.22584798
76Aplasia/Hypoplasia of the fovea (HP:0008060)2.21997324
77Hypoplasia of the fovea (HP:0007750)2.21997324
78Chromsome breakage (HP:0040012)2.17791947
79Ureteral obstruction (HP:0006000)2.16546674
80Abnormal spermatogenesis (HP:0008669)2.14360441
81J-shaped sella turcica (HP:0002680)2.14314290
82Abnormality of oral frenula (HP:0000190)2.13349365
833-Methylglutaconic aciduria (HP:0003535)2.13238033
84Hypoplasia of the thymus (HP:0000778)2.13031838
85Autoimmune thrombocytopenia (HP:0001973)2.12544580
86Abnormality of male internal genitalia (HP:0000022)2.11523653
87Skin rash (HP:0000988)2.10964574
88Vacuolated lymphocytes (HP:0001922)2.09931389
89Aplastic anemia (HP:0001915)2.09847060
90Eosinophilia (HP:0001880)2.09234512
91Pulmonary fibrosis (HP:0002206)2.08617425
92Abnormality of eosinophils (HP:0001879)2.08287399
93Parakeratosis (HP:0001036)2.07976980
94Generalized hypopigmentation of hair (HP:0011358)2.06507010
95Tetraparesis (HP:0002273)2.03870957
96Lip pit (HP:0100267)2.02844896
97Stomatitis (HP:0010280)2.01128159
98Abnormality of the fovea (HP:0000493)2.00605509
99Chronic mucocutaneous candidiasis (HP:0002728)1.99940552
100Recurrent cutaneous fungal infections (HP:0011370)1.99940552
101Median cleft lip (HP:0000161)1.98371428
102Tinnitus (HP:0000360)1.97087408
103Molar tooth sign on MRI (HP:0002419)1.96890698
104Abnormality of midbrain morphology (HP:0002418)1.96890698
105Anorexia (HP:0002039)1.95741043
106Recurrent viral infections (HP:0004429)1.95201527
107Tubulointerstitial nephritis (HP:0001970)1.94096835
108Emphysema (HP:0002097)1.92921941
109Chest pain (HP:0100749)1.92415211
110IgG deficiency (HP:0004315)1.91451227
111Abnormal delayed hypersensitivity skin test (HP:0002963)1.91160782
112Elevated erythrocyte sedimentation rate (HP:0003565)1.89461350
113Paresthesia (HP:0003401)1.88949862
114Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88757510
115Abnormal glucose tolerance (HP:0001952)1.88119623
116Combined immunodeficiency (HP:0005387)1.87675603
117Hematuria (HP:0000790)1.87388160
118Pruritus (HP:0000989)1.86974729
119Abnormal rod and cone electroretinograms (HP:0008323)1.86405061
120Congenital sensorineural hearing impairment (HP:0008527)1.86248241
121Decreased central vision (HP:0007663)1.84883470
122Panhypogammaglobulinemia (HP:0003139)1.84845509
123Recurrent pneumonia (HP:0006532)1.83376516
124Restrictive lung disease (HP:0002091)1.82495092
125Arterial thrombosis (HP:0004420)1.80888111
126Gingival bleeding (HP:0000225)1.80697461
127Gastrointestinal infarctions (HP:0005244)1.80004438
128Malnutrition (HP:0004395)1.79619729
129IgM deficiency (HP:0002850)1.79348195
130IgA deficiency (HP:0002720)1.77556283
131White forelock (HP:0002211)1.77536996
132Methylmalonic acidemia (HP:0002912)1.76769972
133Abnormality of secondary sexual hair (HP:0009888)1.75978939
134Abnormality of the axillary hair (HP:0100134)1.75978939
135Vertigo (HP:0002321)1.75707105
136Diplopia (HP:0000651)1.75582326
137Abnormality of binocular vision (HP:0011514)1.75582326
138Increased serum ferritin (HP:0003281)1.75174227
139Exertional dyspnea (HP:0002875)1.74785766
140Septo-optic dysplasia (HP:0100842)1.74438937
141Pulmonary embolism (HP:0002204)1.74434554
142Polydipsia (HP:0001959)1.74315808
143Abnormal drinking behavior (HP:0030082)1.74315808
144Lymphoma (HP:0002665)1.74198085
145Joint hemorrhage (HP:0005261)1.73843653
146B lymphocytopenia (HP:0010976)1.71968633
147Stomach cancer (HP:0012126)1.71451606
148Granulocytopenia (HP:0001913)1.68833715
149Osteomyelitis (HP:0002754)1.68547118
150Cardiomegaly (HP:0001640)1.66903717
151Aplasia/Hypoplasia of the macula (HP:0008059)1.66715814
152Severe muscular hypotonia (HP:0006829)1.66621003
153Abnormality of the vitamin B12 metabolism (HP:0004341)1.65342305
154Fibular aplasia (HP:0002990)1.65167415
155Febrile seizures (HP:0002373)1.64507659
156Heterochromia iridis (HP:0001100)1.63998547
157Leukocytosis (HP:0001974)1.63991981
158Clubbing of toes (HP:0100760)1.63714204
159Short 1st metacarpal (HP:0010034)1.62826205
160Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.62826205
161Erythroderma (HP:0001019)1.62684328
162Mucosal telangiectasiae (HP:0100579)1.61736784
163Abnormality of renin-angiotensin system (HP:0000847)1.61566802
164Keratoconjunctivitis sicca (HP:0001097)1.59872506
165Bifid uvula (HP:0000193)1.59767830
166Abnormal biliary tract physiology (HP:0012439)1.59221801
167Congenital stationary night blindness (HP:0007642)1.58145927
168Patchy hypopigmentation of hair (HP:0011365)1.57206689
169Congenital, generalized hypertrichosis (HP:0004540)1.56847717
170Pulmonary artery stenosis (HP:0004415)1.56446722

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.54707662
2MAP3K114.33376119
3TXK4.02728787
4MAP3K143.69095866
5MAP3K123.68241026
6EPHA43.50682601
7IRAK43.34621239
8STK392.63396637
9RIPK12.60329047
10TAOK22.50460220
11BLK2.38026563
12IRAK32.33924257
13TBK12.26749023
14RIPK42.22731044
15CSF1R2.09758782
16TYK22.06320461
17IKBKB2.05572644
18BMPR1B2.04230544
19GRK12.03902265
20ITK2.03361925
21SIK31.95298936
22JAK11.88901820
23SYK1.87735366
24ZAK1.87495342
25NEK11.82880570
26NUAK11.82533920
27TNIK1.81931996
28KIT1.72912181
29BMPR21.71028451
30TLK11.67269569
31LYN1.48918833
32CASK1.47276835
33WNK31.41027087
34ACVR1B1.40178725
35TEC1.40111274
36CSK1.37646636
37PBK1.37461612
38MAP4K21.35452122
39MARK31.33923806
40MAP2K61.32188593
41IKBKE1.31535337
42ERBB31.30132942
43STK161.27012530
44TAOK31.26647929
45MYLK1.20974316
46WNK41.19922146
47EIF2AK21.19354288
48MST41.16163513
49ADRBK21.12851940
50BRSK21.11777580
51FES1.08702534
52PAK31.08112328
53PKN11.06898611
54PRKCQ1.06250958
55STK241.04510075
56JAK31.03051974
57CDK190.97499524
58HCK0.96470278
59YES10.93975800
60MAPKAPK30.93713862
61MAP3K40.92733979
62NEK20.89635519
63CLK10.84419977
64PRPF4B0.83514162
65BTK0.81601664
66CHUK0.81228599
67MELK0.78581715
68MAP3K90.78311104
69NEK60.75986810
70NEK90.74594201
71GRK70.74178837
72FGR0.73179061
73PRKCD0.71950807
74MAP3K50.68153982
75LCK0.66516677
76PLK20.66331121
77TNK20.65138934
78TAF10.65096373
79AURKA0.64637761
80FER0.62393866
81DAPK20.62056313
82PRKCZ0.60844730
83PRKCE0.56790523
84OXSR10.55542200
85MAP2K70.55193192
86TYRO30.54362640
87MKNK20.54178339
88PTK2B0.53209878
89TRPM70.52900234
90MATK0.52100138
91CSNK1A1L0.51786749
92NLK0.51445654
93FGFR30.49960023
94PIM10.49672203
95PIM20.49070694
96VRK10.48567446
97MUSK0.46109612
98EIF2AK10.45970632
99PIK3CG0.45420396
100NTRK30.44795938
101CSNK1G10.44719392
102EPHB10.44488714
103CAMK10.44090584
104PDK10.42435273
105HIPK20.38528268
106STK40.38291716
107IRAK10.38290457
108JAK20.38092701
109PRKAA20.37163854
110ABL10.36686929
111SRPK10.36626262
112FRK0.35071815
113TIE10.33876415
114PRKACA0.33601893
115GRK50.32799002
116IGF1R0.31593864
117STK30.31087157
118IRAK20.30847766
119DAPK30.30819226
120CSNK1G30.30757833
121BCR0.30673848
122ADRBK10.29834355
123PRKACG0.29365363
124AKT30.28727750
125MAP3K30.28460326
126ZAP700.27778773
127TGFBR20.27736743
128MAPK130.26352003
129RPS6KB10.25380071
130CAMKK10.24965488
131EPHA30.24153505
132INSRR0.23652888
133MAPK70.22121641
134CDK30.21746570
135MAP3K130.20176162
136PRKG10.19890412
137MAPK30.18928731
138CAMK2A0.18636156
139PRKCA0.17374613
140SGK10.17046131

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000624.30264598
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.08386261
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.70735790
4Leishmaniasis_Homo sapiens_hsa051402.68675068
5Graft-versus-host disease_Homo sapiens_hsa053322.63477779
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.42567416
7Allograft rejection_Homo sapiens_hsa053302.34053190
8Lysosome_Homo sapiens_hsa041422.32003331
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.16981103
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.14272345
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.10092459
12Salmonella infection_Homo sapiens_hsa051322.01550143
13Primary immunodeficiency_Homo sapiens_hsa053401.82735111
14Measles_Homo sapiens_hsa051621.78851571
15Fatty acid metabolism_Homo sapiens_hsa012121.77142728
16Influenza A_Homo sapiens_hsa051641.74958195
17Phagosome_Homo sapiens_hsa041451.71158395
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.71093918
19Rheumatoid arthritis_Homo sapiens_hsa053231.68124564
20Staphylococcus aureus infection_Homo sapiens_hsa051501.67670969
21Malaria_Homo sapiens_hsa051441.67023023
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.65158247
23Legionellosis_Homo sapiens_hsa051341.62979588
24Osteoclast differentiation_Homo sapiens_hsa043801.62145689
25African trypanosomiasis_Homo sapiens_hsa051431.61203256
26Linoleic acid metabolism_Homo sapiens_hsa005911.59171965
27Autoimmune thyroid disease_Homo sapiens_hsa053201.57531916
28Tuberculosis_Homo sapiens_hsa051521.55626448
29Pertussis_Homo sapiens_hsa051331.55132368
30Herpes simplex infection_Homo sapiens_hsa051681.54352987
31Type I diabetes mellitus_Homo sapiens_hsa049401.51207972
32Hematopoietic cell lineage_Homo sapiens_hsa046401.49074855
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.45458701
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.45443038
35* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.42178440
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37425951
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36943766
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.33131614
39TNF signaling pathway_Homo sapiens_hsa046681.31316250
40Shigellosis_Homo sapiens_hsa051311.29557028
41* Chemokine signaling pathway_Homo sapiens_hsa040621.28497297
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27160136
43Asthma_Homo sapiens_hsa053101.20862770
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.19983177
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.18350149
46Antigen processing and presentation_Homo sapiens_hsa046121.18328712
47Toxoplasmosis_Homo sapiens_hsa051451.09891629
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.09297602
49B cell receptor signaling pathway_Homo sapiens_hsa046621.00069515
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98271754
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98180093
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94849278
53Nitrogen metabolism_Homo sapiens_hsa009100.92155681
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90851038
55Phototransduction_Homo sapiens_hsa047440.90061406
56Caffeine metabolism_Homo sapiens_hsa002320.89410136
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88547110
58Other glycan degradation_Homo sapiens_hsa005110.87613550
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85646672
60Systemic lupus erythematosus_Homo sapiens_hsa053220.84511584
61Tryptophan metabolism_Homo sapiens_hsa003800.83199923
62Viral myocarditis_Homo sapiens_hsa054160.81714373
63Sphingolipid metabolism_Homo sapiens_hsa006000.81518903
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79987440
65Hepatitis C_Homo sapiens_hsa051600.76220833
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72833374
67Vitamin digestion and absorption_Homo sapiens_hsa049770.72788152
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70717393
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.70328408
70Mineral absorption_Homo sapiens_hsa049780.70289201
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70244047
72T cell receptor signaling pathway_Homo sapiens_hsa046600.67952598
73Morphine addiction_Homo sapiens_hsa050320.67765775
74Fat digestion and absorption_Homo sapiens_hsa049750.65925830
75Chemical carcinogenesis_Homo sapiens_hsa052040.64657358
76Ovarian steroidogenesis_Homo sapiens_hsa049130.63618437
77Nicotine addiction_Homo sapiens_hsa050330.63404722
78Collecting duct acid secretion_Homo sapiens_hsa049660.62561732
79Taste transduction_Homo sapiens_hsa047420.60502268
80Proteasome_Homo sapiens_hsa030500.59431585
81Platelet activation_Homo sapiens_hsa046110.59228101
82Sulfur metabolism_Homo sapiens_hsa009200.56844958
83Apoptosis_Homo sapiens_hsa042100.55735883
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54930806
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54078638
86Dorso-ventral axis formation_Homo sapiens_hsa043200.51860786
87Arachidonic acid metabolism_Homo sapiens_hsa005900.51500265
88ABC transporters_Homo sapiens_hsa020100.50558983
89Hepatitis B_Homo sapiens_hsa051610.50439479
90Butanoate metabolism_Homo sapiens_hsa006500.48486261
91Epstein-Barr virus infection_Homo sapiens_hsa051690.47674892
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46223389
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45938671
94Glycerolipid metabolism_Homo sapiens_hsa005610.42408531
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.42121141
96Regulation of autophagy_Homo sapiens_hsa041400.42030352
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41206884
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41084692
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40766065
100RNA polymerase_Homo sapiens_hsa030200.40425412
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40005843
102Basal transcription factors_Homo sapiens_hsa030220.39974878
103Complement and coagulation cascades_Homo sapiens_hsa046100.39561527
104Fanconi anemia pathway_Homo sapiens_hsa034600.39524756
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39458703
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39257476
107Ether lipid metabolism_Homo sapiens_hsa005650.37971319
108Histidine metabolism_Homo sapiens_hsa003400.37647296
109Amoebiasis_Homo sapiens_hsa051460.37343687
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36988051
111Olfactory transduction_Homo sapiens_hsa047400.34630708
112Protein export_Homo sapiens_hsa030600.33912934
113beta-Alanine metabolism_Homo sapiens_hsa004100.33560337
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.32562180
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32161942
116Serotonergic synapse_Homo sapiens_hsa047260.31884507
117Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31788859
118Fatty acid degradation_Homo sapiens_hsa000710.31220382
119Calcium signaling pathway_Homo sapiens_hsa040200.31162060
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31111396
121Oxidative phosphorylation_Homo sapiens_hsa001900.30777496
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.30611610
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29338802
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29201788
125HTLV-I infection_Homo sapiens_hsa051660.27135369
126Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26227382
127MAPK signaling pathway_Homo sapiens_hsa040100.25346545
128Retinol metabolism_Homo sapiens_hsa008300.23626707
129Arginine and proline metabolism_Homo sapiens_hsa003300.18120609
130Propanoate metabolism_Homo sapiens_hsa006400.16795519
131Drug metabolism - other enzymes_Homo sapiens_hsa009830.14976582
132p53 signaling pathway_Homo sapiens_hsa041150.09028467
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.08778116
134Salivary secretion_Homo sapiens_hsa049700.08470094
135Peroxisome_Homo sapiens_hsa041460.06835324
136Starch and sucrose metabolism_Homo sapiens_hsa005000.03988679

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