XBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.96653237
2Golgi transport vesicle coating (GO:0048200)6.96653237
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.50193169
4intestinal epithelial cell development (GO:0060576)5.42127148
5protein retention in ER lumen (GO:0006621)5.10643459
6COPII vesicle coating (GO:0048208)4.71035313
7signal peptide processing (GO:0006465)4.69417547
8L-phenylalanine catabolic process (GO:0006559)4.56570798
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.56570798
10positive regulation of keratinocyte differentiation (GO:0045618)4.50032949
11intestinal cholesterol absorption (GO:0030299)4.46188574
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.42579201
13L-phenylalanine metabolic process (GO:0006558)4.42579201
14ear development (GO:0043583)4.39214777
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.16821987
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.16821987
17valine metabolic process (GO:0006573)4.08965870
18retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.08909592
19amyloid precursor protein catabolic process (GO:0042987)4.04733033
20branching involved in mammary gland duct morphogenesis (GO:0060444)4.02796227
21* activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.02130554
22regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.92672348
23complement activation, classical pathway (GO:0006958)3.91314222
24sulfur amino acid catabolic process (GO:0000098)3.87136786
25* positive regulation of nuclease activity (GO:0032075)3.83689884
26proline biosynthetic process (GO:0006561)3.82996169
274-hydroxyproline metabolic process (GO:0019471)3.81704699
28protein carboxylation (GO:0018214)3.75677168
29peptidyl-glutamic acid carboxylation (GO:0017187)3.75677168
30alpha-linolenic acid metabolic process (GO:0036109)3.72981835
31* endoplasmic reticulum unfolded protein response (GO:0030968)3.71908648
32ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.70729911
33maternal placenta development (GO:0001893)3.66395484
34vagina development (GO:0060068)3.65463209
35aromatic amino acid family catabolic process (GO:0009074)3.65306906
36primary alcohol catabolic process (GO:0034310)3.64635253
37uterus development (GO:0060065)3.62427227
38GDP-mannose metabolic process (GO:0019673)3.61075114
39cysteine metabolic process (GO:0006534)3.60632691
40regulation of water loss via skin (GO:0033561)3.60119594
41antigen processing and presentation of endogenous antigen (GO:0019883)3.59526202
42epithelial cell differentiation involved in prostate gland development (GO:0060742)3.59240054
43* cellular response to unfolded protein (GO:0034620)3.57264681
44triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.55823061
45complement activation (GO:0006956)3.53707731
46complement activation, alternative pathway (GO:0006957)3.52838981
47vitamin transmembrane transport (GO:0035461)3.52351305
48hepatocyte apoptotic process (GO:0097284)3.47421647
49* regulation of nuclease activity (GO:0032069)3.46498893
50* ER-nucleus signaling pathway (GO:0006984)3.46058227
51ER overload response (GO:0006983)3.45387224
52positive regulation of Cdc42 GTPase activity (GO:0043089)3.39587084
53* cellular response to topologically incorrect protein (GO:0035967)3.39073652
54protein maturation by protein folding (GO:0022417)3.37543222
55transcytosis (GO:0045056)3.36430817
56negative regulation of fibrinolysis (GO:0051918)3.35972687
57high-density lipoprotein particle remodeling (GO:0034375)3.35118906
58positive regulation of epidermal cell differentiation (GO:0045606)3.32541882
59multicellular organismal water homeostasis (GO:0050891)3.31842452
60ethanol metabolic process (GO:0006067)3.30956563
61regulation of protein activation cascade (GO:2000257)3.30725514
62regulation of keratinocyte differentiation (GO:0045616)3.30530357
63desmosome organization (GO:0002934)3.30390495
64UDP-N-acetylglucosamine metabolic process (GO:0006047)3.29598478
65regulation of cholesterol homeostasis (GO:2000188)3.28941769
66negative regulation of cell size (GO:0045792)3.28183536
67regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.25811785
68sequestering of metal ion (GO:0051238)3.25468259
69glyoxylate metabolic process (GO:0046487)3.22737443
70interferon-gamma secretion (GO:0072643)3.20911503
71reverse cholesterol transport (GO:0043691)3.20773224
72fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.20466489
73* response to endoplasmic reticulum stress (GO:0034976)3.20040290
74vesicle coating (GO:0006901)3.19919895
75lysine metabolic process (GO:0006553)3.19684547
76lysine catabolic process (GO:0006554)3.19684547
77protein N-linked glycosylation via asparagine (GO:0018279)3.18469501
78peptidyl-asparagine modification (GO:0018196)3.16830185
79regulation of complement activation (GO:0030449)3.15488887
80regulation of interleukin-13 production (GO:0032656)3.13284486
81pyrimidine-containing compound transmembrane transport (GO:0072531)3.13186132
82mammary gland epithelial cell differentiation (GO:0060644)3.11702025
83regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.11453100
84intestinal absorption (GO:0050892)3.10286057
85kynurenine metabolic process (GO:0070189)3.09999825
86cellular zinc ion homeostasis (GO:0006882)3.08555518
87homocysteine metabolic process (GO:0050667)3.07873609
88protein activation cascade (GO:0072376)3.07844147
89regulation of glucose import in response to insulin stimulus (GO:2001273)3.06554058
90regulation of histone H3-K27 methylation (GO:0061085)3.06532688
91negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.05795659
92bile acid biosynthetic process (GO:0006699)3.05255902
93positive regulation of nitric-oxide synthase activity (GO:0051000)3.02534027
94urea metabolic process (GO:0019627)3.01542577
95urea cycle (GO:0000050)3.01542577
96apoptotic cell clearance (GO:0043277)3.01453213
97proline metabolic process (GO:0006560)2.99046771
98regulation of triglyceride catabolic process (GO:0010896)2.98823184
99tricarboxylic acid metabolic process (GO:0072350)2.98517047
100tryptophan metabolic process (GO:0006568)2.97535535
101regulation of fibrinolysis (GO:0051917)2.97496656
102phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.96836011
103tryptophan catabolic process (GO:0006569)2.96273095
104indole-containing compound catabolic process (GO:0042436)2.96273095
105indolalkylamine catabolic process (GO:0046218)2.96273095
106trophectodermal cell differentiation (GO:0001829)2.96260511
107cellular modified amino acid catabolic process (GO:0042219)2.95726143
108acylglycerol homeostasis (GO:0055090)2.94452287
109triglyceride homeostasis (GO:0070328)2.94452287
110* exocrine pancreas development (GO:0031017)2.93772085
111mammary gland alveolus development (GO:0060749)2.92975348
112protein N-linked glycosylation (GO:0006487)2.92785725
113plasma lipoprotein particle clearance (GO:0034381)2.92668653
114nitric oxide biosynthetic process (GO:0006809)2.92131278
115regulation of fatty acid beta-oxidation (GO:0031998)2.91984392
116phospholipid efflux (GO:0033700)2.91895972
117positive regulation of triglyceride metabolic process (GO:0090208)2.89314689
118regulation of cell proliferation involved in kidney development (GO:1901722)2.88210229
119positive regulation of cellular amine metabolic process (GO:0033240)2.86332828
120endocrine pancreas development (GO:0031018)2.86170875
121acute-phase response (GO:0006953)2.85958492
122protein-lipid complex remodeling (GO:0034368)2.82237940
123macromolecular complex remodeling (GO:0034367)2.82237940
124plasma lipoprotein particle remodeling (GO:0034369)2.82237940
125maintenance of gastrointestinal epithelium (GO:0030277)2.80202718
126nitrogen cycle metabolic process (GO:0071941)2.78072033
127response to food (GO:0032094)2.73889900
128regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.73500813
129water homeostasis (GO:0030104)2.73358967
130phospholipid homeostasis (GO:0055091)2.71784889
131positive regulation of lipoprotein lipase activity (GO:0051006)2.71107397
132positive regulation of triglyceride lipase activity (GO:0061365)2.71107397
133bile acid metabolic process (GO:0008206)2.71058576
134* response to unfolded protein (GO:0006986)2.70973667
135peptide catabolic process (GO:0043171)2.70221939
136branched-chain amino acid metabolic process (GO:0009081)2.70214845
137amyloid precursor protein metabolic process (GO:0042982)2.70156140
138positive regulation of triglyceride biosynthetic process (GO:0010867)2.70098118
139biotin metabolic process (GO:0006768)2.69751979
140nucleotide-sugar biosynthetic process (GO:0009226)2.68869113
141L-alpha-amino acid transmembrane transport (GO:1902475)2.68573327
142low-density lipoprotein particle clearance (GO:0034383)2.67810457
1432-oxoglutarate metabolic process (GO:0006103)2.66985014
144glutamine family amino acid biosynthetic process (GO:0009084)2.66575675
145surfactant homeostasis (GO:0043129)2.66451361
146aromatic amino acid family metabolic process (GO:0009072)2.65642729
147purine nucleotide transport (GO:0015865)2.64973759
148intracellular estrogen receptor signaling pathway (GO:0030520)2.64728127
149insulin-like growth factor receptor signaling pathway (GO:0048009)2.64535527
150glandular epithelial cell differentiation (GO:0002067)2.64071393
151* response to topologically incorrect protein (GO:0035966)2.63742311
152positive regulation of fatty acid biosynthetic process (GO:0045723)2.63334104
153lipoprotein metabolic process (GO:0042157)2.62599053
154regulation of cholesterol biosynthetic process (GO:0045540)2.62262980
155epoxygenase P450 pathway (GO:0019373)2.62229438
156striated muscle atrophy (GO:0014891)2.61940850
157calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.61169770
158benzene-containing compound metabolic process (GO:0042537)2.60862005
159prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.59985207
160norepinephrine metabolic process (GO:0042415)2.56281182
161negative regulation of fatty acid transport (GO:2000192)2.53602315
162zinc ion transmembrane transport (GO:0071577)2.51590271
163regulation of autophagic vacuole assembly (GO:2000785)2.50963169
164amino-acid betaine transport (GO:0015838)2.49779528
165carnitine transport (GO:0015879)2.49779528
166establishment of skin barrier (GO:0061436)2.49019841
167embryonic process involved in female pregnancy (GO:0060136)2.48794199
168female genitalia development (GO:0030540)2.47460965
169phosphate ion homeostasis (GO:0055062)2.46174828
170trivalent inorganic anion homeostasis (GO:0072506)2.46174828
171endothelial cell chemotaxis (GO:0035767)2.44682120
172embryonic camera-type eye morphogenesis (GO:0048596)2.43881165
173mammary gland epithelial cell proliferation (GO:0033598)2.43564116
174purine ribonucleotide transport (GO:0015868)2.42611271
175columnar/cuboidal epithelial cell development (GO:0002066)2.40262886
176regulation of mammary gland epithelial cell proliferation (GO:0033599)2.38035399
177pinocytosis (GO:0006907)2.38009604
178quaternary ammonium group transport (GO:0015697)2.35848129
179positive regulation of hormone metabolic process (GO:0032352)2.35822994
180prostate gland growth (GO:0060736)2.34686919

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.97482435
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.18023081
3ESR1_20079471_ChIP-ChIP_T-47D_Human5.13109332
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.72977995
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.02657116
6* PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.97465775
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.90271839
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.30122493
9EGR1_23403033_ChIP-Seq_LIVER_Mouse3.25103215
10ESR1_15608294_ChIP-ChIP_MCF-7_Human3.14253793
11* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.98880556
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.97706882
13GATA1_22025678_ChIP-Seq_K562_Human2.84383306
14* CLOCK_20551151_ChIP-Seq_293T_Human2.60605127
15* RUNX1_27514584_Chip-Seq_MCF-7_Human2.52346984
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.51546934
17TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.49491144
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.42815027
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.31102211
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.30501420
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.21295644
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.96960112
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92743276
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.89985379
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.89084579
26* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.84129811
27SOX2_27498859_Chip-Seq_STOMACH_Mouse1.78207821
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78012254
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.76608675
30* ESR1_21235772_ChIP-Seq_MCF-7_Human1.60817990
31* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.60113147
32AHR_22903824_ChIP-Seq_MCF-7_Human1.57313718
33* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55545989
34* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52178169
35ELF5_23300383_ChIP-Seq_T47D_Human1.48623946
36LXR_22292898_ChIP-Seq_THP-1_Human1.45946836
37* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45078774
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39996686
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39913707
40* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38797953
41TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36531681
42MYC_22102868_ChIP-Seq_BL_Human1.36022735
43* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.34464079
44PKCTHETA_26484144_Chip-Seq_BREAST_Human1.33750943
45MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.32529040
46SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32320366
47* GATA4_25053715_ChIP-Seq_YYC3_Human1.31311401
48TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.30235185
49KDM5A_27292631_Chip-Seq_BREAST_Human1.29592250
50* ESR2_21235772_ChIP-Seq_MCF-7_Human1.28010609
51ZNF263_19887448_ChIP-Seq_K562_Human1.27590918
52CDX2_20551321_ChIP-Seq_CACO-2_Human1.27581104
53* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27194322
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26124232
55DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25771810
56* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.20250203
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19980139
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19777221
59CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19370307
60* CREB1_26743006_Chip-Seq_LNCaP_Human1.18921159
61GATA6_25053715_ChIP-Seq_YYC3_Human1.18007261
62RACK7_27058665_Chip-Seq_MCF-7_Human1.17879732
63CHD1_26751641_Chip-Seq_LNCaP_Human1.17008484
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16060893
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15680516
66SOX2_20726797_ChIP-Seq_SW620_Human1.15476589
67* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15134696
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13993373
69* IRF8_27001747_Chip-Seq_BMDM_Mouse1.12882999
70* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11874576
71* FOXA2_19822575_ChIP-Seq_HepG2_Human1.11731181
72* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11696350
73TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10456844
74IRF8_21731497_ChIP-ChIP_J774_Mouse1.09756188
75FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.09517085
76ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09019560
77STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.08617312
78ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08550731
79FOXO3_23340844_ChIP-Seq_DLD1_Human1.07978715
80IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07756449
81TRIM28_21343339_ChIP-Seq_HEK293_Human1.06974824
82ELK3_25401928_ChIP-Seq_HUVEC_Human1.06644866
83* TET1_21451524_ChIP-Seq_MESCs_Mouse1.02942105
84* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02142658
85STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01155990
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00447037
87KDM2B_26808549_Chip-Seq_DND41_Human1.00395533
88SMC4_20622854_ChIP-Seq_HELA_Human1.00272010
89HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00152010
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98429556
91* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97292566
92* VDR_21846776_ChIP-Seq_THP-1_Human0.97239728
93GATA2_21666600_ChIP-Seq_HMVEC_Human0.96673076
94P68_20966046_ChIP-Seq_HELA_Human0.96366909
95AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95889714
96* ATF3_27146783_Chip-Seq_COLON_Human0.95470448
97STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95384317
98VDR_24763502_ChIP-Seq_THP-1_Human0.95069969
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94669072
100* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93886867
101KLF5_25053715_ChIP-Seq_YYC3_Human0.93565419
102GATA1_19941826_ChIP-Seq_K562_Human0.92325070
103* MAF_26560356_Chip-Seq_TH1_Human0.92277389
104PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91960329
105P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91778667
106ARNT_22903824_ChIP-Seq_MCF-7_Human0.91725926
107GATA3_24758297_ChIP-Seq_MCF-7_Human0.91337008
108PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90916060
109* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88831330
110* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88694449
111FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.88515091
112FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88480298
113MYB_26560356_Chip-Seq_TH2_Human0.88115344
114TDRD3_21172665_ChIP-Seq_MCF-7_Human0.87918218
115HIF1A_21447827_ChIP-Seq_MCF-7_Human0.87566472
116PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86895962
117GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85717959
118MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.85518047
119GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85043144
120LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.84384915
121EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.82774091
122* TCF7_22412390_ChIP-Seq_EML_Mouse0.82649821
123SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82500111
124* HNF4A_19822575_ChIP-Seq_HepG2_Human0.82497953
125KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.81034550
126UTX_26944678_Chip-Seq_JUKART_Human0.80305158
127SCL_19346495_ChIP-Seq_HPC-7_Human0.80089478
128ELF1_17652178_ChIP-ChIP_JURKAT_Human0.79284273
129FOXA1_25552417_ChIP-Seq_VCAP_Human0.78412817
130RUNX1_22412390_ChIP-Seq_EML_Mouse0.78302361
131GATA3_27048872_Chip-Seq_THYMUS_Human0.78152784
132DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77702190
133* MYB_26560356_Chip-Seq_TH1_Human0.76448535
134NCOR1_26117541_ChIP-Seq_K562_Human0.76160605
135* TBX20_22328084_ChIP-Seq_HEART_Mouse0.75685326
136* TBX20_22080862_ChIP-Seq_HEART_Mouse0.75685326
137GATA2_19941826_ChIP-Seq_K562_Human0.74811043

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.70213817
2MP0005365_abnormal_bile_salt4.40245143
3MP0005360_urolithiasis3.96735209
4MP0005085_abnormal_gallbladder_physiolo3.64034594
5MP0005083_abnormal_biliary_tract3.28508538
6MP0001666_abnormal_nutrient_absorption3.19173497
7MP0003195_calcinosis2.80595572
8MP0005220_abnormal_exocrine_pancreas2.54660664
9MP0003252_abnormal_bile_duct2.54581752
10MP0008875_abnormal_xenobiotic_pharmacok2.50367664
11MP0003300_gastrointestinal_ulcer2.48621224
12MP0010329_abnormal_lipoprotein_level2.45125287
13MP0009840_abnormal_foam_cell2.36081197
14MP0010234_abnormal_vibrissa_follicle2.31430697
15MP0003191_abnormal_cellular_cholesterol2.27536069
16MP0003806_abnormal_nucleotide_metabolis2.23288683
17MP0002098_abnormal_vibrissa_morphology2.11860378
18MP0005076_abnormal_cell_differentiation2.05318791
19MP0002138_abnormal_hepatobiliary_system1.98558989
20MP0006054_spinal_hemorrhage1.95055162
21MP0000627_abnormal_mammary_gland1.94875135
22MP0010678_abnormal_skin_adnexa1.81308870
23MP0005451_abnormal_body_composition1.79482500
24MP0002877_abnormal_melanocyte_morpholog1.79367263
25MP0003868_abnormal_feces_composition1.78249474
26MP0005058_abnormal_lysosome_morphology1.77146553
27MP0002693_abnormal_pancreas_physiology1.77055417
28MP0009643_abnormal_urine_homeostasis1.74099959
29MP0005332_abnormal_amino_acid1.72906837
30MP0002009_preneoplasia1.71762171
31MP0001944_abnormal_pancreas_morphology1.71647171
32* MP0000609_abnormal_liver_physiology1.71256450
33MP0000013_abnormal_adipose_tissue1.71213179
34MP0001727_abnormal_embryo_implantation1.71118689
35MP0003183_abnormal_peptide_metabolism1.70499609
36MP0005408_hypopigmentation1.68910504
37MP0002118_abnormal_lipid_homeostasis1.67764993
38MP0003705_abnormal_hypodermis_morpholog1.66677239
39MP0000383_abnormal_hair_follicle1.59522792
40MP0003436_decreased_susceptibility_to1.48977427
41MP0005501_abnormal_skin_physiology1.48532069
42MP0005319_abnormal_enzyme/_coenzyme1.45176726
43MP0004019_abnormal_vitamin_homeostasis1.44685746
44MP0002909_abnormal_adrenal_gland1.42253987
45MP0003724_increased_susceptibility_to1.41629131
46MP0001881_abnormal_mammary_gland1.41457226
47MP0004381_abnormal_hair_follicle1.39922118
48MP0003303_peritoneal_inflammation1.34467391
49MP0002132_abnormal_respiratory_system1.33830692
50MP0002006_tumorigenesis1.33437424
51MP0002078_abnormal_glucose_homeostasis1.33241167
52MP0003763_abnormal_thymus_physiology1.29702387
53MP0010368_abnormal_lymphatic_system1.29298381
54MP0005084_abnormal_gallbladder_morpholo1.29234229
55MP0000462_abnormal_digestive_system1.28726286
56MP0001919_abnormal_reproductive_system1.26056496
57MP0009384_cardiac_valve_regurgitation1.26010241
58MP0003453_abnormal_keratinocyte_physiol1.24496637
59MP0001835_abnormal_antigen_presentation1.23877703
60* MP0004264_abnormal_extraembryonic_tissu1.21948578
61MP0000681_abnormal_thyroid_gland1.19790579
62MP0005636_abnormal_mineral_homeostasis1.19345826
63MP0000377_abnormal_hair_follicle1.18380235
64MP0000678_abnormal_parathyroid_gland1.18187053
65MP0001849_ear_inflammation1.17769038
66MP0004185_abnormal_adipocyte_glucose1.14968221
67MP0001764_abnormal_homeostasis1.12012286
68MP0000003_abnormal_adipose_tissue1.11264764
69MP0001216_abnormal_epidermal_layer1.11086166
70MP0008469_abnormal_protein_level1.09924681
71MP0009278_abnormal_bone_marrow1.09564017
72MP0000470_abnormal_stomach_morphology1.08957975
73MP0005584_abnormal_enzyme/coenzyme_acti1.07932198
74MP0001879_abnormal_lymphatic_vessel1.06690737
75MP0001845_abnormal_inflammatory_respons1.05802362
76MP0002928_abnormal_bile_duct1.04611394
77MP0003186_abnormal_redox_activity1.04381343
78MP0003941_abnormal_skin_development1.04304714
79MP0001664_abnormal_digestion1.03509827
80MP0000858_altered_metastatic_potential1.03201673
81MP0004043_abnormal_pH_regulation1.03162605
82MP0001533_abnormal_skeleton_physiology1.03014674
83* MP0000598_abnormal_liver_morphology1.02234267
84MP0004233_abnormal_muscle_weight1.01587862
85MP0001756_abnormal_urination1.01497882
86MP0005646_abnormal_pituitary_gland0.99957713
87MP0008995_early_reproductive_senescence0.99662580
88MP0000538_abnormal_urinary_bladder0.99222377
89MP0000490_abnormal_crypts_of0.99055700
90MP0002254_reproductive_system_inflammat0.98920744
91MP0002160_abnormal_reproductive_system0.98191247
92MP0004947_skin_inflammation0.97661716
93MP0000427_abnormal_hair_cycle0.97119821
94MP0000477_abnormal_intestine_morphology0.96758638
95MP0005075_abnormal_melanosome_morpholog0.96278395
96MP0000467_abnormal_esophagus_morphology0.96122579
97MP0009780_abnormal_chondrocyte_physiolo0.96077947
98MP0004130_abnormal_muscle_cell0.95947537
99MP0003172_abnormal_lysosome_physiology0.95445975
100MP0001873_stomach_inflammation0.94928736
101MP0003936_abnormal_reproductive_system0.94900551
102MP0005670_abnormal_white_adipose0.94026586
103MP0004808_abnormal_hematopoietic_stem0.93679757
104MP0008438_abnormal_cutaneous_collagen0.93589602
105MP0003566_abnormal_cell_adhesion0.92893581
106MP0008260_abnormal_autophagy0.92849176
107MP0001765_abnormal_ion_homeostasis0.92655931
108MP0010155_abnormal_intestine_physiology0.92623042
109MP0003638_abnormal_response/metabolism_0.92548057
110MP0002166_altered_tumor_susceptibility0.92547735
111MP0002277_abnormal_respiratory_mucosa0.89959001
112MP0005464_abnormal_platelet_physiology0.89648572
113MP0004782_abnormal_surfactant_physiolog0.88969865
114MP0009333_abnormal_splenocyte_physiolog0.88694460
115MP0009642_abnormal_blood_homeostasis0.88366436
116MP0003959_abnormal_lean_body0.88147067
117MP0002419_abnormal_innate_immunity0.86071801
118MP0002396_abnormal_hematopoietic_system0.85363996
119* MP0009931_abnormal_skin_appearance0.84634266
120MP0005375_adipose_tissue_phenotype0.83339445
121MP0000465_gastrointestinal_hemorrhage0.83322957
122MP0002876_abnormal_thyroid_physiology0.83283176
123MP0009763_increased_sensitivity_to0.83068228
124MP0005387_immune_system_phenotype0.82792102
125MP0001790_abnormal_immune_system0.82792102
126MP0005025_abnormal_response_to0.81408984
127MP0003283_abnormal_digestive_organ0.81403531
128MP0009785_altered_susceptibility_to0.81169377
129MP0000685_abnormal_immune_system0.80766558
130MP0002089_abnormal_postnatal_growth/wei0.80294712
131MP0005409_darkened_coat_color0.80015715
132MP0002136_abnormal_kidney_physiology0.79834029
133MP0009764_decreased_sensitivity_to0.79411429
134MP0008961_abnormal_basal_metabolism0.78941403
135MP0005000_abnormal_immune_tolerance0.78602863
136MP0005334_abnormal_fat_pad0.77964352
137MP0002896_abnormal_bone_mineralization0.77868532
138MP0001542_abnormal_bone_strength0.77369405
139MP0009672_abnormal_birth_weight0.76877697
140MP0010352_gastrointestinal_tract_polyps0.75189668
141MP0010386_abnormal_urinary_bladder0.74846944
142MP0008004_abnormal_stomach_pH0.74172217
143MP0002971_abnormal_brown_adipose0.72268540
144MP0005448_abnormal_energy_balance0.72240547
145MP0003656_abnormal_erythrocyte_physiolo0.71936767
146MP0003953_abnormal_hormone_level0.70934423
147MP0002933_joint_inflammation0.70779166
148MP0002060_abnormal_skin_morphology0.69158961
149MP0005023_abnormal_wound_healing0.68392860
150MP0002796_impaired_skin_barrier0.67566116
151MP0003866_abnormal_defecation0.66841191
152MP0005666_abnormal_adipose_tissue0.66432717
153MP0000604_amyloidosis0.65715747
154MP0001661_extended_life_span0.65012336

Predicted human phenotypes

RankGene SetZ-score
1J-shaped sella turcica (HP:0002680)4.98681598
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.84838899
3Asymmetry of the thorax (HP:0001555)4.81217344
4Hypoglycemic coma (HP:0001325)4.72880697
5Abnormality of the intrinsic pathway (HP:0010989)4.21339365
6Deep venous thrombosis (HP:0002625)4.07696302
7Flat acetabular roof (HP:0003180)4.07588154
8Xanthomatosis (HP:0000991)3.98028387
9Hypoglycemic seizures (HP:0002173)3.95255233
10Abnormality of the common coagulation pathway (HP:0010990)3.95046001
11Intrahepatic cholestasis (HP:0001406)3.89038214
12Abnormality of monocarboxylic acid metabolism (HP:0010996)3.79116656
13Ketoacidosis (HP:0001993)3.75138053
14Concave nail (HP:0001598)3.68117264
15Ketosis (HP:0001946)3.65790035
16Septate vagina (HP:0001153)3.61836701
17Hyperinsulinemic hypoglycemia (HP:0000825)3.60909523
18Absent frontal sinuses (HP:0002688)3.46957631
19Complement deficiency (HP:0004431)3.45669978
20Sparse lateral eyebrow (HP:0005338)3.42170605
21Prolonged partial thromboplastin time (HP:0003645)3.35219672
22Gout (HP:0001997)3.24954432
23Late onset (HP:0003584)3.22721849
24Symptomatic seizures (HP:0011145)3.20220477
25Mucopolysacchariduria (HP:0008155)3.11525113
26Urinary glycosaminoglycan excretion (HP:0003541)3.11525113
27Fat malabsorption (HP:0002630)3.07991821
28Vacuolated lymphocytes (HP:0001922)3.04716909
29Dysostosis multiplex (HP:0000943)3.00682546
30Thin bony cortex (HP:0002753)2.94977040
31Hyperglycemia (HP:0003074)2.93034258
32Hypobetalipoproteinemia (HP:0003563)2.92801624
33Breast carcinoma (HP:0003002)2.92754685
34Abnormality of purine metabolism (HP:0004352)2.90967339
35Testicular neoplasm (HP:0010788)2.88230080
36Abnormality of the pancreatic islet cells (HP:0006476)2.86088926
37Abnormality of endocrine pancreas physiology (HP:0012093)2.86088926
38Abnormality of mucopolysaccharide metabolism (HP:0011020)2.84039891
39Abnormality of polysaccharide metabolism (HP:0011012)2.84039891
40Abnormality of glycosaminoglycan metabolism (HP:0004371)2.84039891
41Hyperlipoproteinemia (HP:0010980)2.82896749
42Deformed sella turcica (HP:0002681)2.81575814
43Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.80194444
44Joint hemorrhage (HP:0005261)2.79533344
45Conjugated hyperbilirubinemia (HP:0002908)2.79016457
46Generalized aminoaciduria (HP:0002909)2.73615691
47Abnormality of complement system (HP:0005339)2.70666856
48Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.68572005
49Abnormality of the distal phalanges of the toes (HP:0010182)2.68220827
50Germ cell neoplasia (HP:0100728)2.65505141
51Myocardial infarction (HP:0001658)2.59044791
52Abnormality of glutamine family amino acid metabolism (HP:0010902)2.56205292
53Hypolipoproteinemia (HP:0010981)2.54404862
54Right ventricular cardiomyopathy (HP:0011663)2.54185630
55Distal lower limb muscle weakness (HP:0009053)2.51180740
56Hypoalphalipoproteinemia (HP:0003233)2.49240762
57Abnormality of fatty-acid metabolism (HP:0004359)2.49127177
58Hyperparathyroidism (HP:0000843)2.48372582
59Hyperammonemia (HP:0001987)2.47355800
60Recurrent gram-negative bacterial infections (HP:0005420)2.45905163
61Systemic lupus erythematosus (HP:0002725)2.45853556
62Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.45755795
63Nasal polyposis (HP:0100582)2.45083722
64Chronic bronchitis (HP:0004469)2.44055009
65Steatorrhea (HP:0002570)2.43926299
66Interstitial pulmonary disease (HP:0006530)2.41554900
67Abnormality of the frontal sinuses (HP:0002687)2.38313897
68Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.36594461
69Abnormality of nucleobase metabolism (HP:0010932)2.35658376
70Insulin resistance (HP:0000855)2.34108543
71Protuberant abdomen (HP:0001538)2.32475415
72Abnormality of sulfur amino acid metabolism (HP:0004339)2.31305068
73Amelogenesis imperfecta (HP:0000705)2.30702972
74Pili torti (HP:0003777)2.30536763
75Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.30318233
76Abdominal distention (HP:0003270)2.29876188
77Microglossia (HP:0000171)2.29724686
78Curly hair (HP:0002212)2.29635049
79Epidermoid cyst (HP:0200040)2.29204054
80Testicular atrophy (HP:0000029)2.27053961
81Insulin-resistant diabetes mellitus (HP:0000831)2.26870531
82Syringomyelia (HP:0003396)2.26614606
83Spinal cord lesions (HP:0100561)2.26614606
84Long toe (HP:0010511)2.25332701
85Pancreatitis (HP:0001733)2.24365687
86Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.22297323
87Increased neuronal autofluorescent lipopigment (HP:0002074)2.21704636
88Esophageal varix (HP:0002040)2.18463788
89Flattened epiphyses (HP:0003071)2.16419972
90Micronodular cirrhosis (HP:0001413)2.16180140
91Eczematoid dermatitis (HP:0000976)2.16172671
92Hyperglycinuria (HP:0003108)2.16135794
93Spinal cord compression (HP:0002176)2.15123016
94Hyperactive renin-angiotensin system (HP:0000841)2.14629464
95Hyperbilirubinemia (HP:0002904)2.13915657
96Bronchitis (HP:0012387)2.11791984
97Skin nodule (HP:0200036)2.11158644
98Mitral stenosis (HP:0001718)2.10692477
99Abnormality of the nasal mucosa (HP:0000433)2.10308263
100Abnormal foot bone ossification (HP:0010675)2.09086773
101Vascular calcification (HP:0004934)2.07939855
102Villous atrophy (HP:0011473)2.07553235
103Abnormality of small intestinal villus morphology (HP:0011472)2.07553235
104Malnutrition (HP:0004395)2.05494630
105Colitis (HP:0002583)2.04611508
106Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.02001166
107Growth hormone excess (HP:0000845)2.00007823
108Macroorchidism (HP:0000053)1.99939407
109Pancreatic islet-cell hyperplasia (HP:0004510)1.99770462
110Bronchiectasis (HP:0002110)1.99429384
111Congenital glaucoma (HP:0001087)1.98128676
112Nonimmune hydrops fetalis (HP:0001790)1.98002364
113Enlarged penis (HP:0000040)1.96180008
114Hypoparathyroidism (HP:0000829)1.95833059
115Seborrheic dermatitis (HP:0001051)1.95256368
116Cardiovascular calcification (HP:0011915)1.94089160
117Rhinitis (HP:0012384)1.93825987
118Abnormal tarsal ossification (HP:0008369)1.92674555
119Vertebral compression fractures (HP:0002953)1.92161320
120Glomerulonephritis (HP:0000099)1.91984087
121Recurrent bronchitis (HP:0002837)1.89611155
122Abnormality of glycine metabolism (HP:0010895)1.89534939
123Abnormality of serine family amino acid metabolism (HP:0010894)1.89534939
124Abnormal enzyme/coenzyme activity (HP:0012379)1.89525785
125Menorrhagia (HP:0000132)1.89521650
126Hemorrhage of the eye (HP:0011885)1.89409660
127Abnormality of nail color (HP:0100643)1.89368524
128Hydroxyprolinuria (HP:0003080)1.89229005
129Abnormality of proline metabolism (HP:0010907)1.89229005
130Abnormality of transition element cation homeostasis (HP:0011030)1.89047313
131Lymphangioma (HP:0100764)1.88994011
132Hepatocellular carcinoma (HP:0001402)1.88604496
133Hyperglycinemia (HP:0002154)1.88541572
134Retinal atrophy (HP:0001105)1.88344446
135Abnormality of the gastric mucosa (HP:0004295)1.87173587
136Hypercholesterolemia (HP:0003124)1.86656136
137Cervical subluxation (HP:0003308)1.85216866
138Abnormality of the thoracic spine (HP:0100711)1.84716115
139Abnormal hair laboratory examination (HP:0003328)1.84534982
140Lip pit (HP:0100267)1.84355875
141Deep philtrum (HP:0002002)1.82462431
142Cone-rod dystrophy (HP:0000548)1.82438386
143Back pain (HP:0003418)1.82307631
144Hyperuricemia (HP:0002149)1.81699741
145Increased purine levels (HP:0004368)1.81699741
146Increased serum ferritin (HP:0003281)1.80551180
147B lymphocytopenia (HP:0010976)1.80505086
148Elevated alkaline phosphatase (HP:0003155)1.80383301
149Abnormality of alkaline phosphatase activity (HP:0004379)1.80257272
150Exostoses (HP:0100777)1.79344217
151Recurrent otitis media (HP:0000403)1.79229897
152Bone pain (HP:0002653)1.78891331
153Gingival bleeding (HP:0000225)1.78687941
154Agammaglobulinemia (HP:0004432)1.78656301
155Hypophosphatemia (HP:0002148)1.76885954
156Increased cerebral lipofuscin (HP:0011813)1.76838468
157Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76800941
158Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76758443
159Dicarboxylic aciduria (HP:0003215)1.76758443
160Cardiomegaly (HP:0001640)1.76278364
161Reduced antithrombin III activity (HP:0001976)1.76278051
162Irritability (HP:0000737)1.75023979
163Beaking of vertebral bodies (HP:0004568)1.74473314
164Hypercortisolism (HP:0001578)1.73719459
165Myoglobinuria (HP:0002913)1.73246432
166Abnormal pancreas size (HP:0012094)1.71913852
167Gastrointestinal inflammation (HP:0004386)1.71106232
168Abnormality of the umbilical cord (HP:0010881)1.70918319
169Inflammation of the large intestine (HP:0002037)1.70176724
170Abnormal cartilage morphology (HP:0002763)1.69864559
171Stroke (HP:0001297)1.69826546
172Large for gestational age (HP:0001520)1.69362806
173Metabolic acidosis (HP:0001942)1.68708484

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN16.52905957
2BCKDK3.93526277
3TRIB33.23006586
4TAOK33.17156730
5SIK13.01435942
6INSRR2.83138202
7FLT32.72246266
8PKN22.56723170
9SMG12.40951423
10KDR2.32629095
11MAPK152.22349458
12FGFR42.21483850
13MUSK1.99281838
14FRK1.90600783
15PTK61.89432364
16EPHA31.84965158
17RIPK11.67435503
18TYK21.62897472
19NEK61.60156158
20TBK11.60094229
21NME21.60090036
22EPHB11.60019620
23PASK1.58764340
24IRAK31.54895404
25SCYL21.50628079
26TGFBR21.48845018
27ZAP701.46549525
28PIK3CG1.42302496
29MAPKAPK31.39387641
30MAP3K121.36978352
31TESK21.36824004
32JAK31.26286071
33MAP2K31.23614096
34JAK11.22174442
35MAP4K11.21776636
36MAP3K31.21439112
37EIF2AK31.21244059
38HIPK21.20825329
39MAP3K21.20581910
40PRPF4B1.19037457
41EIF2AK11.10748104
42MST1R1.09966991
43CDK71.09504432
44MAP2K21.09273638
45TIE11.07830741
46EEF2K1.06133860
47JAK21.04302427
48MAP3K11.01200494
49RPS6KA21.00557594
50CAMK1D0.97796952
51IRAK40.95893799
52ILK0.95774952
53PIM20.93419377
54NEK90.92952967
55PRKCI0.91434964
56ICK0.90745968
57PTK20.89276077
58PDGFRA0.88207074
59RPS6KB10.87575325
60BTK0.84300576
61FGFR30.83562744
62IRAK10.83394991
63RPS6KC10.82143434
64RPS6KL10.82143434
65MET0.81681300
66LRRK20.80687891
67IKBKE0.79848352
68CSK0.76767480
69FER0.76164092
70TEC0.73030877
71CDK120.72709916
72MAP3K140.72443330
73RET0.72329393
74MAPK110.70769146
75IKBKB0.68804530
76EPHA20.68239395
77SIK30.67704929
78MAP3K100.67496779
79KIT0.66584969
80MAPKAPK20.65585022
81RPS6KA60.64624753
82WNK40.62751936
83TAOK10.62068096
84DYRK1B0.61772444
85TNK20.61578319
86WNK30.60812790
87MAP3K70.60806930
88ITK0.58525598
89BMPR20.57977544
90MAP3K110.55251253
91MATK0.55169360
92CSF1R0.54656624
93PRKG20.53916960
94CAMKK20.53622549
95LATS10.52851837
96NLK0.52046586
97YES10.50059130
98BLK0.49263083
99MAP2K10.48524574
100PDGFRB0.47971865
101CHUK0.47860758
102RPS6KA40.47852891
103TAOK20.47478121
104TRPM70.47188106
105GSK3A0.46439798
106MYLK0.46111797
107PDK10.45778836
108LMTK20.42753092
109IGF1R0.42300755
110MST40.40514492
111NTRK10.40402846
112PRKAA20.39792289
113CAMK1G0.39524996
114MTOR0.38851129
115AKT20.38847811
116GRK60.38153238
117TESK10.38108139
118SYK0.37873457
119CDK60.36740564
120PIK3CA0.36597513
121CDK80.35915763
122PRKCH0.35642002
123PAK40.35527822
124RPS6KA10.33729950
125RPS6KB20.33243614
126PRKD10.31892951
127MAPK30.31458983
128CDC42BPA0.31427564
129EGFR0.30277998
130VRK20.29401694
131MAPK40.28903617
132PAK20.28733148
133DMPK0.28714173
134ERBB40.28442550
135PRKD20.28043792
136LYN0.27801910
137RIPK40.27257323
138PDPK10.27078894
139CAMKK10.27047871
140KSR20.26585948
141PRKAA10.25398924
142TGFBR10.25166563
143MAP2K60.24110651

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.24013075
2Protein export_Homo sapiens_hsa030603.25250330
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.85605916
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.68513983
5* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.48475442
6Caffeine metabolism_Homo sapiens_hsa002322.43140839
7Tryptophan metabolism_Homo sapiens_hsa003802.23743870
8Sulfur metabolism_Homo sapiens_hsa009202.20438509
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.20280863
10Fatty acid degradation_Homo sapiens_hsa000712.11864646
11Complement and coagulation cascades_Homo sapiens_hsa046102.08421692
12Fat digestion and absorption_Homo sapiens_hsa049752.07548591
13Selenocompound metabolism_Homo sapiens_hsa004502.02941644
14Nitrogen metabolism_Homo sapiens_hsa009101.97749280
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.87009177
16Folate biosynthesis_Homo sapiens_hsa007901.86026430
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.85343942
18Hepatitis C_Homo sapiens_hsa051601.77220053
19Arginine biosynthesis_Homo sapiens_hsa002201.71864868
20N-Glycan biosynthesis_Homo sapiens_hsa005101.64598855
21Starch and sucrose metabolism_Homo sapiens_hsa005001.58509564
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.57702268
23Staphylococcus aureus infection_Homo sapiens_hsa051501.57450473
24Thyroid cancer_Homo sapiens_hsa052161.53562235
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51879988
26Histidine metabolism_Homo sapiens_hsa003401.51810941
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.50224446
28Peroxisome_Homo sapiens_hsa041461.48476880
29Propanoate metabolism_Homo sapiens_hsa006401.42480632
30Fatty acid metabolism_Homo sapiens_hsa012121.42322784
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41574742
32PPAR signaling pathway_Homo sapiens_hsa033201.41389951
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.40974785
34Endometrial cancer_Homo sapiens_hsa052131.39294146
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.34867895
36Non-small cell lung cancer_Homo sapiens_hsa052231.34234556
37Galactose metabolism_Homo sapiens_hsa000521.31998349
38Sphingolipid metabolism_Homo sapiens_hsa006001.31439039
39ABC transporters_Homo sapiens_hsa020101.28485014
40Chronic myeloid leukemia_Homo sapiens_hsa052201.25986727
41Other glycan degradation_Homo sapiens_hsa005111.25864052
42Butanoate metabolism_Homo sapiens_hsa006501.24772752
43B cell receptor signaling pathway_Homo sapiens_hsa046621.21480236
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.18719711
45mTOR signaling pathway_Homo sapiens_hsa041501.17903471
46Prostate cancer_Homo sapiens_hsa052151.17346943
47Chemical carcinogenesis_Homo sapiens_hsa052041.15949969
48Lysosome_Homo sapiens_hsa041421.15786254
49beta-Alanine metabolism_Homo sapiens_hsa004101.15194999
50Phenylalanine metabolism_Homo sapiens_hsa003601.14345098
51Longevity regulating pathway - mammal_Homo sapiens_hsa042111.12623530
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09298526
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07896090
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04803477
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00739109
56Pancreatic secretion_Homo sapiens_hsa049721.00663962
57Influenza A_Homo sapiens_hsa051641.00595814
58Pyruvate metabolism_Homo sapiens_hsa006201.00311672
59Pancreatic cancer_Homo sapiens_hsa052120.95948643
60Bile secretion_Homo sapiens_hsa049760.94462329
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94065763
62Glycerolipid metabolism_Homo sapiens_hsa005610.93766524
63Insulin resistance_Homo sapiens_hsa049310.93524232
64VEGF signaling pathway_Homo sapiens_hsa043700.93429844
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93149252
66Protein digestion and absorption_Homo sapiens_hsa049740.91459140
67TNF signaling pathway_Homo sapiens_hsa046680.91325632
68Vitamin digestion and absorption_Homo sapiens_hsa049770.89688740
69Sulfur relay system_Homo sapiens_hsa041220.88690100
70Carbon metabolism_Homo sapiens_hsa012000.88070391
71Tyrosine metabolism_Homo sapiens_hsa003500.85476110
72Biosynthesis of amino acids_Homo sapiens_hsa012300.83777733
73Hepatitis B_Homo sapiens_hsa051610.83510700
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80061756
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.78926653
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77048044
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76321034
78Choline metabolism in cancer_Homo sapiens_hsa052310.75181739
79Pentose phosphate pathway_Homo sapiens_hsa000300.75170886
80Asthma_Homo sapiens_hsa053100.74703492
81Allograft rejection_Homo sapiens_hsa053300.72715921
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72562157
83Renal cell carcinoma_Homo sapiens_hsa052110.71908226
84Measles_Homo sapiens_hsa051620.71105815
85Estrogen signaling pathway_Homo sapiens_hsa049150.71036792
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.70556658
87Fructose and mannose metabolism_Homo sapiens_hsa000510.70294849
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69906360
89Retinol metabolism_Homo sapiens_hsa008300.68715339
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67837996
91Graft-versus-host disease_Homo sapiens_hsa053320.67197116
92Legionellosis_Homo sapiens_hsa051340.65926779
93ErbB signaling pathway_Homo sapiens_hsa040120.65708822
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65096002
95Apoptosis_Homo sapiens_hsa042100.64946409
96Autoimmune thyroid disease_Homo sapiens_hsa053200.64036496
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.63185262
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62277640
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62249187
100Type I diabetes mellitus_Homo sapiens_hsa049400.61447656
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61281464
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60887136
103Vibrio cholerae infection_Homo sapiens_hsa051100.60820634
104Arginine and proline metabolism_Homo sapiens_hsa003300.60086029
105Inositol phosphate metabolism_Homo sapiens_hsa005620.59609899
106Herpes simplex infection_Homo sapiens_hsa051680.59126996
107Renin-angiotensin system_Homo sapiens_hsa046140.57433399
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56789913
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56660631
110Prion diseases_Homo sapiens_hsa050200.56563794
111Lysine degradation_Homo sapiens_hsa003100.56475875
112Fatty acid biosynthesis_Homo sapiens_hsa000610.56249066
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55944836
114Antigen processing and presentation_Homo sapiens_hsa046120.55091051
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.53097099
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52099936
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51804703
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.49584067
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.49466410
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.49043755
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.48453248
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.46863224
123Fatty acid elongation_Homo sapiens_hsa000620.45811454
124Thyroid hormone synthesis_Homo sapiens_hsa049180.41558588
125Leishmaniasis_Homo sapiens_hsa051400.41391409
126Glutathione metabolism_Homo sapiens_hsa004800.41149196
127Type II diabetes mellitus_Homo sapiens_hsa049300.41015534
128Steroid biosynthesis_Homo sapiens_hsa001000.39339721
129Pertussis_Homo sapiens_hsa051330.35527704
130Prolactin signaling pathway_Homo sapiens_hsa049170.31087354
131Glucagon signaling pathway_Homo sapiens_hsa049220.30597564
132AMPK signaling pathway_Homo sapiens_hsa041520.28204589
133Bladder cancer_Homo sapiens_hsa052190.26824746
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26155947
135Metabolic pathways_Homo sapiens_hsa011000.25221348
136Insulin secretion_Homo sapiens_hsa049110.24735349
137Toll-like receptor signaling pathway_Homo sapiens_hsa046200.24040464
138Toxoplasmosis_Homo sapiens_hsa051450.24002243
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23798037
140Insulin signaling pathway_Homo sapiens_hsa049100.21652460
141Central carbon metabolism in cancer_Homo sapiens_hsa052300.21044896
142Acute myeloid leukemia_Homo sapiens_hsa052210.20849256

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