XAGE3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is expressed in placenta and fetal liver/spleen, and may function in inhibiting cancer cell growth. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 2 transcript variants differing in the 5' UTR. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)8.67823891
2desmosome organization (GO:0002934)8.61483208
3lung-associated mesenchyme development (GO:0060484)8.24539011
4positive regulation of protein kinase C signaling (GO:0090037)8.04013271
5regulation of transforming growth factor beta2 production (GO:0032909)7.92308484
6bundle of His cell to Purkinje myocyte communication (GO:0086069)6.61737496
7regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)6.52275174
8notochord development (GO:0030903)6.47781538
9branching involved in salivary gland morphogenesis (GO:0060445)6.25014171
10post-embryonic morphogenesis (GO:0009886)6.14594405
11regulation of odontogenesis (GO:0042481)5.98842618
12fucose catabolic process (GO:0019317)5.81382121
13L-fucose metabolic process (GO:0042354)5.81382121
14L-fucose catabolic process (GO:0042355)5.81382121
15regulation of glycogen (starch) synthase activity (GO:2000465)5.61324115
16negative regulation of stem cell proliferation (GO:2000647)5.59044736
17hippo signaling (GO:0035329)5.58735755
18regulation of branching involved in prostate gland morphogenesis (GO:0060687)5.58101338
19positive regulation of insulin receptor signaling pathway (GO:0046628)5.57901072
20auditory receptor cell stereocilium organization (GO:0060088)5.55202103
21positive regulation of hormone biosynthetic process (GO:0046886)5.12633721
22cranial suture morphogenesis (GO:0060363)4.95896952
23exocrine pancreas development (GO:0031017)4.95704282
24pH reduction (GO:0045851)4.88051222
25cornea development in camera-type eye (GO:0061303)4.84395232
26polarized epithelial cell differentiation (GO:0030859)4.79357957
27vitamin D metabolic process (GO:0042359)4.73549895
28positive regulation of hormone metabolic process (GO:0032352)4.57619906
29trophectodermal cell differentiation (GO:0001829)4.54633734
30L-ascorbic acid metabolic process (GO:0019852)4.50325111
31cellular hyperosmotic response (GO:0071474)4.29469603
32fucose metabolic process (GO:0006004)4.22287698
33folic acid transport (GO:0015884)4.21206909
34non-canonical Wnt signaling pathway (GO:0035567)4.18275403
35cell migration in hindbrain (GO:0021535)4.16672005
36cellular response to gamma radiation (GO:0071480)4.14651225
37positive regulation of transforming growth factor beta production (GO:0071636)4.14547541
38positive regulation of odontogenesis (GO:0042482)4.13336453
39positive regulation of cellular response to insulin stimulus (GO:1900078)4.04615477
40regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.92377018
41wound healing, spreading of epidermal cells (GO:0035313)3.91973785
42tooth mineralization (GO:0034505)3.91077800
43semaphorin-plexin signaling pathway (GO:0071526)3.90287275
44dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.89575294
45bone trabecula formation (GO:0060346)3.89195300
46outflow tract septum morphogenesis (GO:0003148)3.86505372
47nephron tubule formation (GO:0072079)3.84634152
48intestinal epithelial cell development (GO:0060576)3.83127826
49fucosylation (GO:0036065)3.82735010
50adrenal gland development (GO:0030325)3.81461882
51regulation of sister chromatid cohesion (GO:0007063)3.81005312
52bone mineralization (GO:0030282)3.78985721
53ventricular septum morphogenesis (GO:0060412)3.73941113
54positive regulation of hair cycle (GO:0042635)3.72804752
55positive regulation of hair follicle development (GO:0051798)3.72804752
56regulation of response to osmotic stress (GO:0047484)3.71368861
57L-alpha-amino acid transmembrane transport (GO:1902475)3.65965832
58regulation of protein kinase C signaling (GO:0090036)3.63693155
59establishment of apical/basal cell polarity (GO:0035089)3.59714676
60response to vitamin A (GO:0033189)3.58570191
61transferrin transport (GO:0033572)3.50765612
62mesenchyme development (GO:0060485)3.50634654
63protein localization to cell surface (GO:0034394)3.48908899
64epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.44737700
65negative regulation of calcium ion transport into cytosol (GO:0010523)3.38841513
66regulation of keratinocyte proliferation (GO:0010837)3.38028187
67keratinocyte development (GO:0003334)3.34850957
68cellular zinc ion homeostasis (GO:0006882)3.32821844
69negative regulation of epidermal cell differentiation (GO:0045605)3.32532621
70osteoblast development (GO:0002076)3.31306103
71regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.30398909
72vitamin transmembrane transport (GO:0035461)3.28977696
73phospholipid scrambling (GO:0017121)3.25652962
74biomineral tissue development (GO:0031214)3.24962955
75erythrocyte maturation (GO:0043249)3.23744718
76nitric oxide biosynthetic process (GO:0006809)3.22498659
77trivalent inorganic cation transport (GO:0072512)3.20886800
78ferric iron transport (GO:0015682)3.20886800
79inner ear receptor stereocilium organization (GO:0060122)3.20360353
80tight junction assembly (GO:0070830)3.17458132
81establishment of epithelial cell polarity (GO:0090162)3.14061425
82regulation of steroid hormone biosynthetic process (GO:0090030)3.11956028
83neuron remodeling (GO:0016322)3.11757423
84branching involved in labyrinthine layer morphogenesis (GO:0060670)3.11543846
85estrogen biosynthetic process (GO:0006703)3.11262424
86energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.10131298
87ATP hydrolysis coupled proton transport (GO:0015991)3.10131298
88craniofacial suture morphogenesis (GO:0097094)3.06893054
89regulation of mesenchymal cell apoptotic process (GO:2001053)3.06285525
90genitalia morphogenesis (GO:0035112)3.04336755
91regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.04157441
92positive regulation of steroid biosynthetic process (GO:0010893)3.03847725
93definitive hemopoiesis (GO:0060216)3.01952017
94somatic stem cell maintenance (GO:0035019)2.97964884
95regulation of cellular respiration (GO:0043457)2.97380806
96establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.97302562
97phagosome maturation (GO:0090382)2.97014747
98COPI coating of Golgi vesicle (GO:0048205)2.95777143
99Golgi transport vesicle coating (GO:0048200)2.95777143
100viral transcription (GO:0019083)2.95644634

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human8.19123581
2ZNF263_19887448_ChIP-Seq_K562_Human6.87578537
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.61685339
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.61685339
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.61685339
6CDX2_20551321_ChIP-Seq_CACO-2_Human4.15033951
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.99254989
8ESR2_21235772_ChIP-Seq_MCF-7_Human3.40162675
9HIF1A_21447827_ChIP-Seq_MCF-7_Human2.87071935
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.81485360
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.77530955
12TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.50454128
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.38050746
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.22477456
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.19399819
16ERG_21242973_ChIP-ChIP_JURKAT_Human2.08376975
17BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.97685528
18AR_21909140_ChIP-Seq_LNCAP_Human1.85088909
19GATA4_25053715_ChIP-Seq_YYC3_Human1.79588198
20ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.74242350
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.73666722
22RUNX1_27514584_Chip-Seq_MCF-7_Human1.72629859
23MYC_19079543_ChIP-ChIP_MESCs_Mouse1.72261244
24GATA3_24758297_ChIP-Seq_MCF-7_Human1.67292467
25SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.61014238
26FOXM1_23109430_ChIP-Seq_U2OS_Human1.57134825
27AHR_22903824_ChIP-Seq_MCF-7_Human1.53595773
28NANOG_21062744_ChIP-ChIP_HESCs_Human1.50353695
29KLF5_25053715_ChIP-Seq_YYC3_Human1.46831635
30MYC_18555785_ChIP-Seq_MESCs_Mouse1.43774736
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35408422
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.33837419
33GATA6_25053715_ChIP-Seq_YYC3_Human1.33198504
34RACK7_27058665_Chip-Seq_MCF-7_Human1.33035349
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31854327
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.25737160
37HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25533107
38LXR_22292898_ChIP-Seq_THP-1_Human1.23710936
39SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20648048
40* ELF5_23300383_ChIP-Seq_T47D_Human1.18841442
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17625818
42TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17615204
43SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16139305
44ARNT_22903824_ChIP-Seq_MCF-7_Human1.15790351
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12196740
46GATA1_26923725_Chip-Seq_HPCs_Mouse1.12129028
47EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.09423245
48PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08379233
49TP53_20018659_ChIP-ChIP_R1E_Mouse1.07869543
50GATA1_19941826_ChIP-Seq_K562_Human1.07757360
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07610592
52NANOG_18692474_ChIP-Seq_MEFs_Mouse1.06992468
53P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06931890
54SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05003436
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04986940
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04729085
57JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.04531163
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02255527
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00588175
60POU5F1_16518401_ChIP-PET_MESCs_Mouse0.97255444
61ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96933162
62PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96836660
63ISL1_27105846_Chip-Seq_CPCs_Mouse0.95990519
64STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.95299484
65TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95083839
66PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.94638197
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.93837705
68TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92900076
69SMC4_20622854_ChIP-Seq_HELA_Human0.91732849
70TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.91385850
71SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90445540
72JARID2_20064375_ChIP-Seq_MESCs_Mouse0.90068952
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89569260
74SOX2_20726797_ChIP-Seq_SW620_Human0.88551353
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87986086
76ATF3_27146783_Chip-Seq_COLON_Human0.87799234
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85552929
78KDM2B_26808549_Chip-Seq_K562_Human0.84770428
79TCF3_18692474_ChIP-Seq_MEFs_Mouse0.84655833
80STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84465060
81NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.84106099
82TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.81473915
83SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.81358093
84FOXO3_23340844_ChIP-Seq_DLD1_Human0.79982546
85NFIB_24661679_ChIP-Seq_LUNG_Mouse0.79945714
86SCL_19346495_ChIP-Seq_HPC-7_Human0.79671658
87NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.79596720
88SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.72217194
89CBP_21632823_ChIP-Seq_H3396_Human0.69748188
90RING1B_27294783_Chip-Seq_NPCs_Mouse0.69342983
91ETS1_21867929_ChIP-Seq_TH2_Mouse0.68858426
92NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.68069393
93MYC_18358816_ChIP-ChIP_MESCs_Mouse0.67111911
94EZH2_27304074_Chip-Seq_ESCs_Mouse0.66590684
95ZFX_18555785_ChIP-Seq_MESCs_Mouse0.66469107
96MYC_19030024_ChIP-ChIP_MESCs_Mouse0.64578555
97NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.63424090
98NANOG_18692474_ChIP-Seq_MESCs_Mouse0.62674452
99CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.62431058
100OCT4_18692474_ChIP-Seq_MEFs_Mouse0.62169104

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot9.03823762
2MP0003878_abnormal_ear_physiology9.03823762
3MP0004264_abnormal_extraembryonic_tissu6.48023360
4MP0002098_abnormal_vibrissa_morphology4.33280161
5MP0000383_abnormal_hair_follicle3.56966365
6MP0003941_abnormal_skin_development3.43255952
7MP0010678_abnormal_skin_adnexa2.85420410
8MP0010234_abnormal_vibrissa_follicle2.79280095
9MP0000647_abnormal_sebaceous_gland2.70748769
10MP0000566_synostosis2.38743086
11MP0003122_maternal_imprinting2.34371893
12MP0003567_abnormal_fetal_cardiomyocyte2.19923089
13MP0003879_abnormal_hair_cell2.18891167
14MP0005076_abnormal_cell_differentiation2.18108232
15MP0000377_abnormal_hair_follicle2.10206512
16MP0002796_impaired_skin_barrier2.09090781
17MP0004782_abnormal_surfactant_physiolog1.80198254
18MP0010307_abnormal_tumor_latency1.78617938
19MP0004019_abnormal_vitamin_homeostasis1.67568235
20MP0003385_abnormal_body_wall1.64300783
21MP0003123_paternal_imprinting1.62276925
22MP0000427_abnormal_hair_cycle1.61907346
23MP0001485_abnormal_pinna_reflex1.59409740
24MP0001293_anophthalmia1.59258681
25MP0000579_abnormal_nail_morphology1.55138238
26MP0005367_renal/urinary_system_phenotyp1.55078803
27MP0000516_abnormal_urinary_system1.55078803
28MP0003890_abnormal_embryonic-extraembry1.52345731
29MP0003942_abnormal_urinary_system1.50151885
30MP0003693_abnormal_embryo_hatching1.40426938
31MP0005451_abnormal_body_composition1.10698296
32MP0004957_abnormal_blastocyst_morpholog1.08254424
33MP0009053_abnormal_anal_canal1.07613163
34MP0001216_abnormal_epidermal_layer1.03516788
35MP0005501_abnormal_skin_physiology0.99352152
36MP0004742_abnormal_vestibular_system0.98224159
37MP0002697_abnormal_eye_size0.96872709
38MP0004858_abnormal_nervous_system0.94534298
39MP0000639_abnormal_adrenal_gland0.88560141
40MP0009703_decreased_birth_body0.87007289
41MP0001324_abnormal_eye_pigmentation0.81364322
42MP0000537_abnormal_urethra_morphology0.80935455
43MP0000367_abnormal_coat/_hair0.80662881
44MP0001348_abnormal_lacrimal_gland0.79983442
45MP0002092_abnormal_eye_morphology0.79557637
46MP0005646_abnormal_pituitary_gland0.79468590
47MP0004185_abnormal_adipocyte_glucose0.77842027
48MP0002998_abnormal_bone_remodeling0.77400694
49MP0001958_emphysema0.77077190
50MP0000432_abnormal_head_morphology0.75492165
51MP0003935_abnormal_craniofacial_develop0.74914031
52MP0009931_abnormal_skin_appearance0.72663045
53MP0001346_abnormal_lacrimal_gland0.71804351
54MP0005197_abnormal_uvea_morphology0.69569337
55MP0003787_abnormal_imprinting0.68410541
56MP0003936_abnormal_reproductive_system0.66914680
57MP0003329_amyloid_beta_deposits0.66611237
58MP0002249_abnormal_larynx_morphology0.66432049
59MP0001340_abnormal_eyelid_morphology0.64835096
60MP0009672_abnormal_birth_weight0.64354725
61MP0003638_abnormal_response/metabolism_0.64335744
62MP0008004_abnormal_stomach_pH0.64271737
63MP0002086_abnormal_extraembryonic_tissu0.64161746
64MP0004947_skin_inflammation0.64098071
65MP0010030_abnormal_orbit_morphology0.63388366
66MP0000534_abnormal_ureter_morphology0.61217038
67MP0005636_abnormal_mineral_homeostasis0.60224414
68MP0010771_integument_phenotype0.59460795
69MP0003566_abnormal_cell_adhesion0.59171412
70MP0008770_decreased_survivor_rate0.59031023
71MP0002938_white_spotting0.58980895
72MP0005666_abnormal_adipose_tissue0.58171629
73MP0009333_abnormal_splenocyte_physiolog0.56272854
74MP0003937_abnormal_limbs/digits/tail_de0.55458559
75MP0000462_abnormal_digestive_system0.55283624
76MP0003632_abnormal_nervous_system0.54943073
77MP0002138_abnormal_hepatobiliary_system0.54744948
78MP0009379_abnormal_foot_pigmentation0.54665907
79MP0009115_abnormal_fat_cell0.53514830
80MP0002896_abnormal_bone_mineralization0.51747789
81MP0003453_abnormal_keratinocyte_physiol0.50930130
82MP0003119_abnormal_digestive_system0.49681202
83MP0010352_gastrointestinal_tract_polyps0.49674200
84MP0004197_abnormal_fetal_growth/weight/0.47657852
85MP0000627_abnormal_mammary_gland0.47585650
86MP0005409_darkened_coat_color0.47269781
87MP0008872_abnormal_physiological_respon0.46416847
88MP0001697_abnormal_embryo_size0.44776765
89MP0000026_abnormal_inner_ear0.44732286
90MP0005380_embryogenesis_phenotype0.43929152
91MP0001672_abnormal_embryogenesis/_devel0.43929152
92MP0002396_abnormal_hematopoietic_system0.43417047
93MP0001730_embryonic_growth_arrest0.43205738
94MP0001486_abnormal_startle_reflex0.41107144
95MP0002909_abnormal_adrenal_gland0.40714960
96MP0003705_abnormal_hypodermis_morpholog0.40037834
97MP0002127_abnormal_cardiovascular_syste0.38818404
98MP0001765_abnormal_ion_homeostasis0.37601526
99MP0001177_atelectasis0.37514425
100MP0005375_adipose_tissue_phenotype0.36243035

Predicted human phenotypes

RankGene SetZ-score
1Bilateral sensorineural hearing impairment (HP:0008619)6.90589392
2Asymmetry of the thorax (HP:0001555)6.51033955
3Myelomeningocele (HP:0002475)5.50613040
4Abnormality of dental color (HP:0011073)5.50018320
5Bicornuate uterus (HP:0000813)5.36784205
6Choanal stenosis (HP:0000452)5.20070674
7Right ventricular cardiomyopathy (HP:0011663)5.06892169
8Increased circulating renin level (HP:0000848)4.85139442
9Renal tubular acidosis (HP:0001947)4.81025297
10Absent eyebrow (HP:0002223)4.68830670
11Cone-rod dystrophy (HP:0000548)4.36013696
12Bilateral microphthalmos (HP:0007633)4.23593115
13Proximal tubulopathy (HP:0000114)4.20628128
14High anterior hairline (HP:0009890)4.12657097
15Metaphyseal cupping (HP:0003021)4.02671684
16Curly hair (HP:0002212)3.98816019
17Tetany (HP:0001281)3.95103212
18Aplasia of the musculature (HP:0100854)3.88241378
19Paralysis (HP:0003470)3.78585049
20Hypomagnesemia (HP:0002917)3.76203769
21Abnormality of the parietal bone (HP:0002696)3.67201670
22Woolly hair (HP:0002224)3.64684123
23Absent eyelashes (HP:0000561)3.63878685
24Partial agenesis of the corpus callosum (HP:0001338)3.54344681
25Aplasia cutis congenita (HP:0001057)3.42342992
26Abnormality of the lacrimal duct (HP:0011481)3.38629884
27Amelogenesis imperfecta (HP:0000705)3.37999640
28Central scotoma (HP:0000603)3.37516262
29Concave nail (HP:0001598)3.34510250
30Morphological abnormality of the middle ear (HP:0008609)3.29849399
31Abnormality of magnesium homeostasis (HP:0004921)3.17296956
32Renal tubular dysfunction (HP:0000124)3.14877750
33Bifid tongue (HP:0010297)3.09743552
34Advanced eruption of teeth (HP:0006288)2.98652261
35Abnormal lung lobation (HP:0002101)2.96989515
36Abnormal tarsal ossification (HP:0008369)2.93163653
37Abnormality of macular pigmentation (HP:0008002)2.91614057
38Abnormality of the nasolacrimal system (HP:0000614)2.82564390
39Metaphyseal dysplasia (HP:0100255)2.81042997
40Bony spicule pigmentary retinopathy (HP:0007737)2.80758765
41Meningocele (HP:0002435)2.80270502
42Severe Myopia (HP:0011003)2.78203867
43Midline defect of the nose (HP:0004122)2.76997994
44Hypoplasia of the iris (HP:0007676)2.75112165
45Absent hair (HP:0002298)2.74736734
46Facial cleft (HP:0002006)2.73049718
47Abnormality of the pubic bones (HP:0003172)2.65945589
48Hypokalemic alkalosis (HP:0001949)2.61577409
49Pterygium (HP:0001059)2.60509736
50Pallor (HP:0000980)2.60490029
51Delayed epiphyseal ossification (HP:0002663)2.52450785
52Abolished electroretinogram (ERG) (HP:0000550)2.43813039
53Abnormal urine phosphate concentration (HP:0012599)2.43283366
54Aplastic anemia (HP:0001915)2.39406309
55Aplasia/Hypoplasia involving the musculature (HP:0001460)2.34190664
56Hyperphosphaturia (HP:0003109)2.34141150
57Ulnar deviation of the wrist (HP:0003049)2.33735811
58Nephroblastoma (Wilms tumor) (HP:0002667)2.33068265
59Attenuation of retinal blood vessels (HP:0007843)2.29342717
60Clitoromegaly (HP:0000057)2.28535902
61Stenosis of the external auditory canal (HP:0000402)2.27858973
62Abnormal auditory evoked potentials (HP:0006958)2.25995281
63Cutaneous finger syndactyly (HP:0010554)2.23677344
64Embryonal renal neoplasm (HP:0011794)2.21315540
65Absent phalangeal crease (HP:0006109)2.13437546
66Abnormal foot bone ossification (HP:0010675)2.12730583
67Congenital ichthyosiform erythroderma (HP:0007431)2.12090234
68Widely patent fontanelles and sutures (HP:0004492)2.10377592
69Aplasia/Hypoplasia of the sternum (HP:0006714)2.10170886
70Bell-shaped thorax (HP:0001591)2.10160640
71Ridged nail (HP:0001807)2.06558390
72Omphalocele (HP:0001539)2.03321862
73Megaloblastic anemia (HP:0001889)2.00119834
74Wide intermamillary distance (HP:0006610)1.99721113
75Chorioretinal atrophy (HP:0000533)1.95864557
76Cubitus valgus (HP:0002967)1.95354951
77Hypoparathyroidism (HP:0000829)1.93419179
78Abnormality of calcium-phosphate metabolism (HP:0100530)1.93052196
79Abnormality of the salivary glands (HP:0010286)1.92845626
80Macrocytic anemia (HP:0001972)1.92218567
81Abnormal finger flexion creases (HP:0006143)1.87581139
82Hypoplastic labia majora (HP:0000059)1.86015536
83Cupped ear (HP:0000378)1.84850110
84Cutaneous syndactyly (HP:0012725)1.81171045
85Abnormality of the labia majora (HP:0012881)1.80654214
86Neonatal death (HP:0003811)1.79649880
87Ectopic anus (HP:0004397)1.74689585
88Ventricular tachycardia (HP:0004756)1.73021236
89Pili torti (HP:0003777)1.72258682
90Split foot (HP:0001839)1.71134279
91Anophthalmia (HP:0000528)1.69850778
92Scotoma (HP:0000575)1.68449309
93Tracheal stenosis (HP:0002777)1.68343169
94Palpitations (HP:0001962)1.66820626
95Abnormal drinking behavior (HP:0030082)1.66759368
96Polydipsia (HP:0001959)1.66759368
97Hypophosphatemia (HP:0002148)1.66685572
98Skull defect (HP:0001362)1.66387503
99Atresia of the external auditory canal (HP:0000413)1.66279627
100Partial duplication of thumb phalanx (HP:0009944)1.65985272

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS19.48302565
2LATS26.43155013
3STK38L6.40002036
4NME15.21586231
5STK393.84077739
6WNK43.45956591
7EPHA23.36226993
8OXSR13.03940611
9STK382.61890578
10STK32.07601153
11DAPK21.90560069
12MST41.90146354
13RPS6KA41.67281085
14NME21.62263813
15MAP3K71.61024876
16FGFR21.07949852
17MST1R0.99042359
18AKT30.81649034
19STK240.81305988
20PLK40.81060190
21DAPK10.74534405
22NEK20.61473169
23FGFR10.59677130
24DAPK30.59546930
25EIF2AK30.54761159
26MET0.53428308
27WEE10.49327700
28FGR0.49229727
29SCYL20.45535475
30LRRK20.38345543
31CDK120.38227030
32TTK0.36378705
33EIF2AK10.35952982
34DYRK1B0.35113113
35RPS6KL10.32661739
36RPS6KC10.32661739
37CSK0.32010713
38BMX0.31745888
39PRKCI0.30824508
40MAP2K10.30584883
41BRD40.28681941
42PAK40.28440506
43BCR0.28084743
44RPS6KA20.27474412
45YES10.26840609
46BMPR20.26402340
47MATK0.26042716
48TRPM70.25118187
49RPS6KA60.24983451
50PTK20.24140752
51CDC42BPA0.24106208
52PLK20.22732718
53TYRO30.22499909
54PDGFRA0.22271458
55MARK20.21988629
56AURKB0.21834080
57DDR20.21442816
58FER0.20590008
59CAMK40.20161284
60PRKG20.18915791
61ABL20.18766515
62NEK90.18261107
63STK100.18065891
64CSNK1A10.17004196
65RIPK10.16747482
66PDGFRB0.15626286
67ICK0.15284749
68CAMK2G0.15205333
69PTK2B0.14097160
70MTOR0.12313276
71ABL10.11887281
72RPS6KB20.11670549
73PKN10.11271573
74MAPK10.10808305
75MAP3K120.10680794
76AKT20.10368404
77MAP2K60.09961267
78CSNK1D0.09854564
79PBK0.09774240
80PLK10.09682992
81MAPK110.08806400
82CDK10.08373612
83ZAP700.08368709
84ILK0.08000346
85SRC0.07975263
86SRPK10.07909660
87PRKAA20.07590919
88RPS6KA10.06737518
89PRKD20.06369476
90AURKA0.06175923
91MAP3K20.05604323
92CHEK10.05558706
93EPHB10.05517875
94CLK10.05098211
95MAP2K40.04925567
96BRSK10.04905301
97CSNK1E0.04784024
98NEK60.04175506
99CSNK2A10.04001866
100PRKCA0.03826403

Predicted pathways (KEGG)

RankGene SetZ-score
1Collecting duct acid secretion_Homo sapiens_hsa049665.98205086
2Hedgehog signaling pathway_Homo sapiens_hsa043404.51614547
3Basal cell carcinoma_Homo sapiens_hsa052173.72431543
4Vibrio cholerae infection_Homo sapiens_hsa051103.64845907
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.15928366
6Hippo signaling pathway_Homo sapiens_hsa043902.93742970
7Ribosome_Homo sapiens_hsa030102.93232116
8Folate biosynthesis_Homo sapiens_hsa007902.66560621
9Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051202.50446262
10Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.24115722
11Synaptic vesicle cycle_Homo sapiens_hsa047212.10605935
12Vitamin digestion and absorption_Homo sapiens_hsa049772.06867301
13Mineral absorption_Homo sapiens_hsa049781.76071337
14Adherens junction_Homo sapiens_hsa045201.69152521
15Melanogenesis_Homo sapiens_hsa049161.61121555
16Wnt signaling pathway_Homo sapiens_hsa043101.59093437
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45132976
18Bladder cancer_Homo sapiens_hsa052191.36411555
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.32415982
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.32345969
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.29754952
22Tight junction_Homo sapiens_hsa045301.24641022
23Homologous recombination_Homo sapiens_hsa034401.24572152
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21012735
25Non-homologous end-joining_Homo sapiens_hsa034501.18851178
26N-Glycan biosynthesis_Homo sapiens_hsa005101.17581886
27Notch signaling pathway_Homo sapiens_hsa043301.16709592
28Pathways in cancer_Homo sapiens_hsa052001.14580105
29Other glycan degradation_Homo sapiens_hsa005111.12046692
30Ovarian steroidogenesis_Homo sapiens_hsa049131.07940156
31Proteoglycans in cancer_Homo sapiens_hsa052051.06220966
32Oxidative phosphorylation_Homo sapiens_hsa001901.04257921
33Axon guidance_Homo sapiens_hsa043601.01076575
34Thyroid cancer_Homo sapiens_hsa052160.98788646
35ECM-receptor interaction_Homo sapiens_hsa045120.98687156
36Small cell lung cancer_Homo sapiens_hsa052220.98326044
37Arginine biosynthesis_Homo sapiens_hsa002200.98026333
38Fatty acid biosynthesis_Homo sapiens_hsa000610.97353357
39Rheumatoid arthritis_Homo sapiens_hsa053230.94287453
40Endocytosis_Homo sapiens_hsa041440.94174601
41Renal cell carcinoma_Homo sapiens_hsa052110.88283257
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87271305
43HIF-1 signaling pathway_Homo sapiens_hsa040660.86701322
44Nucleotide excision repair_Homo sapiens_hsa034200.86457508
45Endometrial cancer_Homo sapiens_hsa052130.85910357
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85875245
47mRNA surveillance pathway_Homo sapiens_hsa030150.83056040
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82348479
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82323286
50Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81478031
51Spliceosome_Homo sapiens_hsa030400.80865979
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77946747
53Thyroid hormone synthesis_Homo sapiens_hsa049180.74595593
54Mismatch repair_Homo sapiens_hsa034300.73384985
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70070291
56Galactose metabolism_Homo sapiens_hsa000520.69397253
57Ras signaling pathway_Homo sapiens_hsa040140.69245857
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.69149802
59ABC transporters_Homo sapiens_hsa020100.68494172
60DNA replication_Homo sapiens_hsa030300.64951650
61Fructose and mannose metabolism_Homo sapiens_hsa000510.63867286
62Choline metabolism in cancer_Homo sapiens_hsa052310.62754513
63Renin-angiotensin system_Homo sapiens_hsa046140.62430027
64Dorso-ventral axis formation_Homo sapiens_hsa043200.59412558
65PPAR signaling pathway_Homo sapiens_hsa033200.57789784
66Inositol phosphate metabolism_Homo sapiens_hsa005620.56019430
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53676240
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51632328
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50549041
70Focal adhesion_Homo sapiens_hsa045100.49806256
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.48565184
72Arginine and proline metabolism_Homo sapiens_hsa003300.45586886
73Phagosome_Homo sapiens_hsa041450.45112837
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.44214429
75Amoebiasis_Homo sapiens_hsa051460.42546118
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42479422
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40599862
78RNA transport_Homo sapiens_hsa030130.39881505
79Sulfur relay system_Homo sapiens_hsa041220.39719814
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39057709
81Insulin signaling pathway_Homo sapiens_hsa049100.38482624
82RNA degradation_Homo sapiens_hsa030180.36916527
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.35966353
84Pentose phosphate pathway_Homo sapiens_hsa000300.35451441
85Base excision repair_Homo sapiens_hsa034100.33373966
86Long-term depression_Homo sapiens_hsa047300.30704658
87Ether lipid metabolism_Homo sapiens_hsa005650.30407878
88VEGF signaling pathway_Homo sapiens_hsa043700.29890449
89Cell cycle_Homo sapiens_hsa041100.29773489
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29268035
91Biosynthesis of amino acids_Homo sapiens_hsa012300.28785339
92p53 signaling pathway_Homo sapiens_hsa041150.28255895
93Pyruvate metabolism_Homo sapiens_hsa006200.28066761
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.26788511
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26554621
96HTLV-I infection_Homo sapiens_hsa051660.26311760
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25627037
98Colorectal cancer_Homo sapiens_hsa052100.24452796
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.24366201
100Hepatitis C_Homo sapiens_hsa051600.23609893

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