XAGE1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene, in addition to alternative transcription start sites, results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)6.31567671
2establishment of integrated proviral latency (GO:0075713)6.13808882
3establishment of viral latency (GO:0019043)5.68100378
4COPI coating of Golgi vesicle (GO:0048205)4.80350384
5Golgi transport vesicle coating (GO:0048200)4.80350384
6DNA unwinding involved in DNA replication (GO:0006268)4.73961625
7ribosome assembly (GO:0042255)4.62553327
8proteasome assembly (GO:0043248)4.59854327
9mitotic nuclear envelope reassembly (GO:0007084)4.34570640
10nuclear envelope reassembly (GO:0031468)4.34570640
11formation of translation preinitiation complex (GO:0001731)4.25204810
12gonadal mesoderm development (GO:0007506)4.00809647
13ribosomal large subunit biogenesis (GO:0042273)3.98872936
14negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.93479363
15regulation of mitotic spindle organization (GO:0060236)3.82927396
16positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.74172894
17anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.67638212
18regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.64349043
19maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.59688450
20negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.59670741
21negative regulation of ligase activity (GO:0051352)3.59670741
22telomere maintenance via semi-conservative replication (GO:0032201)3.59640878
23protein retention in ER lumen (GO:0006621)3.58920116
24negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.58330343
25nucleobase-containing small molecule interconversion (GO:0015949)3.55383734
26membrane raft organization (GO:0031579)3.51852092
27muscle cell migration (GO:0014812)3.49010819
28lipopolysaccharide biosynthetic process (GO:0009103)3.45904830
29positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.43639055
30galactose catabolic process (GO:0019388)3.40616675
31regulation of metalloenzyme activity (GO:0048552)3.35811353
32regulation of cellular amino acid metabolic process (GO:0006521)3.35702180
33extracellular fibril organization (GO:0043206)3.34972272
34mitotic chromosome condensation (GO:0007076)3.30068252
35DNA strand elongation involved in DNA replication (GO:0006271)3.29853940
36DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.28457157
37mitotic metaphase plate congression (GO:0007080)3.28359802
38deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.27865630
39detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.27781462
40intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.27242582
41signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.27242582
42regulation of spindle organization (GO:0090224)3.26426763
43positive regulation of ligase activity (GO:0051351)3.25587571
44morphogenesis of an endothelium (GO:0003159)3.24749385
45endothelial tube morphogenesis (GO:0061154)3.24749385
46DNA strand elongation (GO:0022616)3.23807705
47mitotic sister chromatid segregation (GO:0000070)3.21023927
48signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.20509448
49signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.20509448
50signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.20509448
51negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.19488714
52signal transduction involved in DNA damage checkpoint (GO:0072422)3.19101003
53signal transduction involved in DNA integrity checkpoint (GO:0072401)3.19101003
54regulation of mitochondrial translation (GO:0070129)3.19030767
55signal transduction involved in cell cycle checkpoint (GO:0072395)3.10630398
56ribonucleoprotein complex biogenesis (GO:0022613)3.09393635
57proline biosynthetic process (GO:0006561)3.03345059
58response to gravity (GO:0009629)3.02053274
59AMP metabolic process (GO:0046033)3.00620672
60regulation of ubiquitin-protein transferase activity (GO:0051438)3.00488351
61protein targeting to mitochondrion (GO:0006626)2.97370750
62antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.97337712
63ribosomal small subunit assembly (GO:0000028)2.96102139
64mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.94640165
65ribosomal small subunit biogenesis (GO:0042274)2.93937070
66telomere maintenance via recombination (GO:0000722)2.92442767
67metaphase plate congression (GO:0051310)2.91481671
68regulation of translational fidelity (GO:0006450)2.90429366
69ribosome biogenesis (GO:0042254)2.89532685
70regulation of ligase activity (GO:0051340)2.87152542
71regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.86921322
72positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.86295517
73mitotic recombination (GO:0006312)2.85436823
74transcription-coupled nucleotide-excision repair (GO:0006283)2.84501214
75positive regulation of actin filament depolymerization (GO:0030836)2.81247601
76sister chromatid segregation (GO:0000819)2.80166563
77GDP-mannose metabolic process (GO:0019673)2.78422096
78positive regulation of DNA-dependent DNA replication (GO:2000105)2.77734588
79actin filament depolymerization (GO:0030042)2.76361858
80mitotic nuclear envelope disassembly (GO:0007077)2.74378516
81fibril organization (GO:0097435)2.74077493
82antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.73621212
83lipopolysaccharide metabolic process (GO:0008653)2.72217080
84negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.69438861
85guanosine-containing compound biosynthetic process (GO:1901070)2.68450433
86heterochromatin organization (GO:0070828)2.66888900
87cellular component biogenesis (GO:0044085)2.64732463
88establishment of protein localization to mitochondrion (GO:0072655)2.63735508
89galactose metabolic process (GO:0006012)2.62918357
90cellular copper ion homeostasis (GO:0006878)2.62315382
91protein localization to mitochondrion (GO:0070585)2.61245217
927-methylguanosine mRNA capping (GO:0006370)2.60784693
93translation (GO:0006412)2.60618553
94energy coupled proton transport, down electrochemical gradient (GO:0015985)2.60333993
95ATP synthesis coupled proton transport (GO:0015986)2.60333993
96deoxyribonucleotide biosynthetic process (GO:0009263)2.58868016
97de novo protein folding (GO:0006458)2.57844487
98detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.57637250
99chaperone-mediated protein transport (GO:0072321)2.53599413
100negative regulation of protein ubiquitination (GO:0031397)2.53518117

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.93241204
2E2F7_22180533_ChIP-Seq_HELA_Human3.89960212
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.22524777
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.15692145
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.09692505
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.07923904
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.03853610
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.99578420
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.89753188
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.76103809
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.67466655
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.54328427
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.52626151
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.41808869
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.39821466
16DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.36261701
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.29041348
18DCP1A_22483619_ChIP-Seq_HELA_Human2.27145355
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.26029051
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.25141778
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.23499856
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19191597
23ZNF263_19887448_ChIP-Seq_K562_Human2.14605926
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.12453772
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12204324
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11137882
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10307808
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.08145425
29XRN2_22483619_ChIP-Seq_HELA_Human2.04906166
30GABP_19822575_ChIP-Seq_HepG2_Human1.91189870
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.90924754
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.89737203
33AR_21909140_ChIP-Seq_LNCAP_Human1.89394244
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.87117134
35ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.81743920
36ELK1_19687146_ChIP-ChIP_HELA_Human1.72845314
37PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.68228124
38VDR_23849224_ChIP-Seq_CD4+_Human1.63559222
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.62662339
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.61869197
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.60556332
42TTF2_22483619_ChIP-Seq_HELA_Human1.60296902
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58866786
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55779095
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54337087
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51881691
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47400319
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44752965
49CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.42911268
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42564609
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41934264
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41906786
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41051888
54TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40857971
55FOXP3_21729870_ChIP-Seq_TREG_Human1.40355058
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39258845
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39062115
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38754695
59TFEB_21752829_ChIP-Seq_HELA_Human1.38205933
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.37834853
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.37086332
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.35897850
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.35156044
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34602146
65ATF3_27146783_Chip-Seq_COLON_Human1.30197380
66KDM5A_27292631_Chip-Seq_BREAST_Human1.29661706
67KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29588622
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28700488
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.28598567
70HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.28221180
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27515222
72PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.26812143
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26437719
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.25428754
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24976029
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24694992
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21649779
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21231792
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.20575527
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19235897
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16058445
82TBX5_21415370_ChIP-Seq_HL-1_Mouse1.15494635
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.15023032
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14951906
85VDR_21846776_ChIP-Seq_THP-1_Human1.14207550
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13072383
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11666370
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10389510
89KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09904914
90SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09517022
91STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08204350
92SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07970415
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07970415
94CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07242487
95SOX17_20123909_ChIP-Seq_XEN_Mouse1.07133836
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05976983
97NCOR1_26117541_ChIP-Seq_K562_Human1.05742204
98EGR1_19374776_ChIP-ChIP_THP-1_Human1.02716338
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96665574
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94173749

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.41254055
2MP0003191_abnormal_cellular_cholesterol3.34846352
3MP0003123_paternal_imprinting3.32628341
4MP0003950_abnormal_plasma_membrane3.11043609
5MP0004957_abnormal_blastocyst_morpholog2.89873606
6MP0003806_abnormal_nucleotide_metabolis2.85175314
7MP0009697_abnormal_copulation2.84665180
8MP0003693_abnormal_embryo_hatching2.78345732
9MP0003786_premature_aging2.60552142
10MP0003111_abnormal_nucleus_morphology2.50743658
11MP0008007_abnormal_cellular_replicative2.44185716
12MP0010094_abnormal_chromosome_stability2.38602102
13MP0005058_abnormal_lysosome_morphology2.37896404
14MP0003077_abnormal_cell_cycle2.35530132
15MP0000750_abnormal_muscle_regeneration2.34609835
16MP0005257_abnormal_intraocular_pressure2.23972140
17MP0008058_abnormal_DNA_repair2.18546502
18MP0003656_abnormal_erythrocyte_physiolo2.16887478
19MP0000751_myopathy2.13265721
20MP0008932_abnormal_embryonic_tissue2.12439683
21MP0010030_abnormal_orbit_morphology2.10333851
22MP0005451_abnormal_body_composition2.10157185
23MP0000749_muscle_degeneration2.05580521
24MP0001853_heart_inflammation2.03833472
25MP0002332_abnormal_exercise_endurance1.98462723
26MP0005360_urolithiasis1.96044745
27MP0004272_abnormal_basement_membrane1.80602774
28MP0005165_increased_susceptibility_to1.78614838
29MP0003566_abnormal_cell_adhesion1.73509606
30MP0003186_abnormal_redox_activity1.71097859
31MP0000358_abnormal_cell_content/1.62656440
32MP0000858_altered_metastatic_potential1.62570716
33MP0004147_increased_porphyrin_level1.61579283
34MP0005083_abnormal_biliary_tract1.56425272
35MP0005330_cardiomyopathy1.55703683
36MP0009840_abnormal_foam_cell1.53621329
37MP0003718_maternal_effect1.52942128
38MP0001542_abnormal_bone_strength1.52784916
39MP0003315_abnormal_perineum_morphology1.49414810
40MP0006036_abnormal_mitochondrial_physio1.45914873
41MP0000350_abnormal_cell_proliferation1.44628401
42MP0006035_abnormal_mitochondrial_morpho1.38993470
43MP0005408_hypopigmentation1.36793000
44MP0004510_myositis1.35163457
45MP0001730_embryonic_growth_arrest1.32469818
46MP0000647_abnormal_sebaceous_gland1.31696645
47MP0002060_abnormal_skin_morphology1.30224600
48MP0008775_abnormal_heart_ventricle1.28181258
49MP0000343_altered_response_to1.27638537
50MP0009780_abnormal_chondrocyte_physiolo1.22407170
51MP0005464_abnormal_platelet_physiology1.20534470
52MP0004233_abnormal_muscle_weight1.18137508
53MP0002080_prenatal_lethality1.15583445
54MP0005670_abnormal_white_adipose1.11251385
55MP0001243_abnormal_dermal_layer1.10298311
56MP0003075_altered_response_to1.10161314
57MP0000313_abnormal_cell_death1.06448984
58MP0005197_abnormal_uvea_morphology1.04061792
59MP0002019_abnormal_tumor_incidence1.03170901
60MP0000747_muscle_weakness1.03135857
61MP0001697_abnormal_embryo_size1.02186798
62MP0005501_abnormal_skin_physiology1.02157320
63MP0003705_abnormal_hypodermis_morpholog0.99219507
64MP0005367_renal/urinary_system_phenotyp0.94643230
65MP0000516_abnormal_urinary_system0.94643230
66MP0008995_early_reproductive_senescence0.94475514
67MP0009333_abnormal_splenocyte_physiolog0.94203080
68MP0003221_abnormal_cardiomyocyte_apopto0.91225284
69MP0005164_abnormal_response_to0.91144713
70MP0003984_embryonic_growth_retardation0.90265254
71MP0008260_abnormal_autophagy0.87650508
72MP0001672_abnormal_embryogenesis/_devel0.87052649
73MP0005380_embryogenesis_phenotype0.87052649
74MP0001299_abnormal_eye_distance/0.86197623
75MP0005384_cellular_phenotype0.85235443
76MP0002269_muscular_atrophy0.84497444
77MP0002088_abnormal_embryonic_growth/wei0.82850128
78MP0001216_abnormal_epidermal_layer0.81493689
79MP0001545_abnormal_hematopoietic_system0.79232509
80MP0005397_hematopoietic_system_phenotyp0.79232509
81MP0004185_abnormal_adipocyte_glucose0.78844257
82MP0002796_impaired_skin_barrier0.77370050
83MP0005584_abnormal_enzyme/coenzyme_acti0.76840420
84MP0005621_abnormal_cell_physiology0.74797496
85MP0002177_abnormal_outer_ear0.74597845
86MP0008057_abnormal_DNA_replication0.73885696
87MP0000762_abnormal_tongue_morphology0.73148187
88MP0000609_abnormal_liver_physiology0.72078623
89MP0002086_abnormal_extraembryonic_tissu0.71691304
90MP0001881_abnormal_mammary_gland0.71548517
91MP0000759_abnormal_skeletal_muscle0.71406906
92MP0001661_extended_life_span0.70536500
93MP0003453_abnormal_keratinocyte_physiol0.70325896
94MP0002210_abnormal_sex_determination0.69112477
95MP0008438_abnormal_cutaneous_collagen0.68344965
96MP0005266_abnormal_metabolism0.68063848
97MP0005023_abnormal_wound_healing0.67375130
98MP0003943_abnormal_hepatobiliary_system0.66608474
99MP0002095_abnormal_skin_pigmentation0.62551850
100MP0005395_other_phenotype0.62287940

Predicted human phenotypes

RankGene SetZ-score
1Reduced subcutaneous adipose tissue (HP:0003758)4.44436294
2Upper limb muscle weakness (HP:0003484)4.20492331
3Cholecystitis (HP:0001082)4.07924239
4Abnormal gallbladder physiology (HP:0012438)4.07924239
5Glucose intolerance (HP:0000833)3.99238585
6Osteolytic defects of the hand bones (HP:0009699)3.72270857
7Osteolytic defects of the phalanges of the hand (HP:0009771)3.72270857
8Entropion (HP:0000621)3.64207166
9Amyloidosis (HP:0011034)3.63307800
10Increased serum pyruvate (HP:0003542)3.56572432
11Adrenal hypoplasia (HP:0000835)3.52184040
12Abnormality of glycolysis (HP:0004366)3.44427858
13Short nail (HP:0001799)3.38209831
14Premature rupture of membranes (HP:0001788)3.27718185
15Abnormal mitochondria in muscle tissue (HP:0008316)3.10088390
16Acute necrotizing encephalopathy (HP:0006965)3.09077516
17Abnormality of the distal phalanges of the toes (HP:0010182)3.06708501
18Rough bone trabeculation (HP:0100670)2.95168013
19Reduced antithrombin III activity (HP:0001976)2.86680043
20Increased connective tissue (HP:0009025)2.84466849
21Hepatocellular necrosis (HP:0001404)2.81566658
22Delayed CNS myelination (HP:0002188)2.80504682
23Vertebral compression fractures (HP:0002953)2.80494190
24Microglossia (HP:0000171)2.78129013
25Acute encephalopathy (HP:0006846)2.78037172
26Distal lower limb amyotrophy (HP:0008944)2.77824045
27Distal lower limb muscle weakness (HP:0009053)2.68782404
28Mitochondrial inheritance (HP:0001427)2.67854543
29Type I transferrin isoform profile (HP:0003642)2.67044754
30Hypertensive crisis (HP:0100735)2.65947904
31Orthostatic hypotension (HP:0001278)2.60689351
32Fatigue (HP:0012378)2.58677840
33Hand muscle atrophy (HP:0009130)2.56610334
34Abnormal glucose tolerance (HP:0001952)2.53193927
35Shoulder girdle muscle weakness (HP:0003547)2.49913468
36Hepatic necrosis (HP:0002605)2.48826295
37Myocardial infarction (HP:0001658)2.47823475
38Secondary amenorrhea (HP:0000869)2.44406582
39Insulin resistance (HP:0000855)2.42765314
40Progressive macrocephaly (HP:0004481)2.41487465
41Increased CSF lactate (HP:0002490)2.40202242
42Abnormality of the umbilical cord (HP:0010881)2.38975860
43Exercise intolerance (HP:0003546)2.34158523
44Pelvic girdle muscle weakness (HP:0003749)2.34106264
45Abnormal autonomic nervous system physiology (HP:0012332)2.31011966
46Abnormal platelet function (HP:0011869)2.30915984
47Impaired platelet aggregation (HP:0003540)2.30915984
48Sparse eyelashes (HP:0000653)2.30710546
49Insomnia (HP:0100785)2.30512875
50Aplasia/Hypoplasia of the sacrum (HP:0008517)2.29713143
51Distal upper limb amyotrophy (HP:0007149)2.27371748
52Upper limb amyotrophy (HP:0009129)2.27371748
53Renal Fanconi syndrome (HP:0001994)2.24196196
54Abnormal trabecular bone morphology (HP:0100671)2.23905156
55Vascular calcification (HP:0004934)2.22628884
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22518900
57Abnormality of alanine metabolism (HP:0010916)2.22518900
58Hyperalaninemia (HP:0003348)2.22518900
59Decreased subcutaneous fat (HP:0001002)2.20131648
60Increased serum lactate (HP:0002151)2.19130690
61Abnormal protein glycosylation (HP:0012346)2.16481655
62Abnormal glycosylation (HP:0012345)2.16481655
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16481655
64Abnormal protein N-linked glycosylation (HP:0012347)2.16481655
65Difficulty climbing stairs (HP:0003551)2.13208768
66Decreased activity of mitochondrial respiratory chain (HP:0008972)2.12875063
67Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.12875063
68Limb-girdle muscle atrophy (HP:0003797)2.12636906
69Ileus (HP:0002595)2.10283672
70Increased hepatocellular lipid droplets (HP:0006565)2.09234955
71Abnormality of the hip-girdle musculature (HP:0001445)2.08323213
72Abnormality of the musculature of the pelvis (HP:0001469)2.08323213
73Deviation of the thumb (HP:0009603)2.07284815
74Cholelithiasis (HP:0001081)2.04963570
75Proximal placement of thumb (HP:0009623)2.04886875
76Abnormal hemoglobin (HP:0011902)2.02808345
77Progressive muscle weakness (HP:0003323)2.02756003
78Hepatosplenomegaly (HP:0001433)2.01537488
79Hepatocellular carcinoma (HP:0001402)1.99803103
80Lactic acidosis (HP:0003128)1.98880276
81Achilles tendon contracture (HP:0001771)1.98570789
82Hypergonadotropic hypogonadism (HP:0000815)1.97038178
83Abnormality of the intrinsic pathway (HP:0010989)1.96636525
84Ureteral duplication (HP:0000073)1.95970628
85Abnormality of aromatic amino acid family metabolism (HP:0004338)1.95798137
86Male infertility (HP:0003251)1.94287320
87Abnormalities of placenta or umbilical cord (HP:0001194)1.93322970
88Spastic paraparesis (HP:0002313)1.92722685
89Cerebral edema (HP:0002181)1.92074144
90Hyperbilirubinemia (HP:0002904)1.91907021
91Flattened epiphyses (HP:0003071)1.91775862
92Conjugated hyperbilirubinemia (HP:0002908)1.91277804
93Hypokinesia (HP:0002375)1.91227066
94Palpitations (HP:0001962)1.90395398
95Increased intramyocellular lipid droplets (HP:0012240)1.87855779
96Onycholysis (HP:0001806)1.86959401
97Reticulocytosis (HP:0001923)1.86176826
98Abnormality of reticulocytes (HP:0004312)1.84157495
99Trismus (HP:0000211)1.82870975
100Short clavicles (HP:0000894)1.82846484

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.31661164
2TESK23.94428612
3MST1R3.85631374
4VRK23.84733908
5TESK13.83979679
6EPHA23.44385273
7BUB13.29584184
8LIMK13.16900200
9IRAK32.94189159
10ARAF2.43481655
11EIF2AK12.27239850
12NEK12.15804851
13LMTK22.06979833
14SCYL21.96779186
15SRPK11.96173166
16PAK41.87926915
17PIM21.73125398
18MET1.71413908
19STK101.70458194
20MOS1.52925757
21ERN11.50929675
22ERBB41.41208173
23CCNB11.40467400
24DAPK11.39534485
25TAOK21.32610420
26MAP2K71.30577271
27MST41.29497297
28BRAF1.26116340
29BRSK11.22914823
30MAP3K121.19766723
31BMX1.12466524
32ABL21.08989353
33CDK81.08611521
34PBK1.06803707
35ILK1.06782342
36EIF2AK31.02053073
37PTK21.01738811
38CDC71.01565047
39ICK1.01003530
40STK160.97547271
41BCKDK0.95219027
42AURKA0.94138921
43MAPKAPK30.92791707
44NEK20.92303095
45RAF10.92139596
46TTK0.90685074
47PAK10.88727294
48VRK10.88574000
49MAP3K80.88323049
50TSSK60.85296600
51LRRK20.82332497
52AURKB0.78627791
53PRPF4B0.75627946
54WEE10.72449120
55PLK10.71299931
56PHKG10.69645235
57PHKG20.69645235
58PDK20.68460136
59BRSK20.66400642
60CDK70.65674179
61EIF2AK20.64126152
62PLK40.64064268
63PTK2B0.61862820
64ERBB30.61323125
65RPS6KB20.61297901
66PRKCI0.60029471
67NME10.59446179
68CLK10.59103324
69KDR0.58332711
70PLK30.53618315
71CHEK20.48187521
72CSNK1G30.46637130
73BMPR20.46356237
74CSNK2A20.40621308
75TBK10.40520187
76CSNK1A1L0.38131792
77MYLK0.37751611
78CDK140.36065762
79CDK180.35233405
80CDK11A0.34963280
81CDK150.33760244
82DAPK30.33501252
83CHEK10.31874735
84HIPK20.31657559
85TGFBR20.31338379
86MAPKAPK20.30872152
87STK40.30386049
88TRPM70.28139558
89EPHB10.27442033
90ATR0.27221735
91RPS6KA50.25430544
92MAP2K30.24205994
93MAP3K60.23793031
94PAK20.23553165
95SIK30.23365279
96RPS6KA40.22246306
97PAK60.22015287
98MAP3K30.22011529
99CSNK2A10.21967387
100TTN0.21403233

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.70197861
2DNA replication_Homo sapiens_hsa030303.84355228
3Ribosome_Homo sapiens_hsa030103.07671298
4Mismatch repair_Homo sapiens_hsa034303.04613387
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.76653807
6Oxidative phosphorylation_Homo sapiens_hsa001902.41218896
7RNA polymerase_Homo sapiens_hsa030202.39883297
8Pyrimidine metabolism_Homo sapiens_hsa002402.37529604
9Base excision repair_Homo sapiens_hsa034102.35986750
10Nucleotide excision repair_Homo sapiens_hsa034202.35057876
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.27805828
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.10328645
13Sulfur relay system_Homo sapiens_hsa041222.09748051
14Parkinsons disease_Homo sapiens_hsa050122.08564536
15Folate biosynthesis_Homo sapiens_hsa007902.05118059
16Fatty acid elongation_Homo sapiens_hsa000621.96995696
17Homologous recombination_Homo sapiens_hsa034401.96205986
18Biosynthesis of amino acids_Homo sapiens_hsa012301.92384661
19Huntingtons disease_Homo sapiens_hsa050161.87986115
20Pentose phosphate pathway_Homo sapiens_hsa000301.80933664
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.72317816
22N-Glycan biosynthesis_Homo sapiens_hsa005101.63793772
23Alzheimers disease_Homo sapiens_hsa050101.63280789
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.60173970
25Spliceosome_Homo sapiens_hsa030401.59904617
26RNA transport_Homo sapiens_hsa030131.59672959
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.51669127
28Galactose metabolism_Homo sapiens_hsa000521.51415112
29Carbon metabolism_Homo sapiens_hsa012001.51119059
30Pyruvate metabolism_Homo sapiens_hsa006201.50775039
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50033337
32Glutathione metabolism_Homo sapiens_hsa004801.44567753
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.44080002
34Fructose and mannose metabolism_Homo sapiens_hsa000511.44010585
35Cell cycle_Homo sapiens_hsa041101.33634872
36Other glycan degradation_Homo sapiens_hsa005111.15869111
37One carbon pool by folate_Homo sapiens_hsa006701.15577028
38Purine metabolism_Homo sapiens_hsa002301.12951935
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.10089242
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04201558
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02943315
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01853762
43Sulfur metabolism_Homo sapiens_hsa009201.00641172
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95242912
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95232168
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.92669310
47Non-homologous end-joining_Homo sapiens_hsa034500.92208877
48Vibrio cholerae infection_Homo sapiens_hsa051100.91429031
49Fanconi anemia pathway_Homo sapiens_hsa034600.90267677
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87417562
51Protein export_Homo sapiens_hsa030600.86982203
52Basal transcription factors_Homo sapiens_hsa030220.86106043
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82534780
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.78899368
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78760526
56Shigellosis_Homo sapiens_hsa051310.71523443
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69596728
58Metabolic pathways_Homo sapiens_hsa011000.68498059
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.66783339
60Apoptosis_Homo sapiens_hsa042100.64882921
61Epstein-Barr virus infection_Homo sapiens_hsa051690.63448554
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.59554813
63Bladder cancer_Homo sapiens_hsa052190.58106736
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55351507
65RNA degradation_Homo sapiens_hsa030180.55186053
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54683673
67Pancreatic cancer_Homo sapiens_hsa052120.53923065
68Tyrosine metabolism_Homo sapiens_hsa003500.53803727
69p53 signaling pathway_Homo sapiens_hsa041150.53578198
70Cardiac muscle contraction_Homo sapiens_hsa042600.52866672
71Viral carcinogenesis_Homo sapiens_hsa052030.50048671
72Thyroid cancer_Homo sapiens_hsa052160.48260145
73mRNA surveillance pathway_Homo sapiens_hsa030150.47938406
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47867687
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47835407
76Steroid biosynthesis_Homo sapiens_hsa001000.47730544
77Salivary secretion_Homo sapiens_hsa049700.46379042
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44489198
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41428088
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.39507145
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38685202
82Phenylalanine metabolism_Homo sapiens_hsa003600.37193146
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37141890
84Lysosome_Homo sapiens_hsa041420.34624938
85HIF-1 signaling pathway_Homo sapiens_hsa040660.33414401
86Oocyte meiosis_Homo sapiens_hsa041140.29522335
87Endocytosis_Homo sapiens_hsa041440.28726451
88Salmonella infection_Homo sapiens_hsa051320.28250828
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26511277
90Arginine and proline metabolism_Homo sapiens_hsa003300.24657121
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24085956
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23547525
93Chronic myeloid leukemia_Homo sapiens_hsa052200.23217671
94Legionellosis_Homo sapiens_hsa051340.22211494
95Arginine biosynthesis_Homo sapiens_hsa002200.20720042
96Herpes simplex infection_Homo sapiens_hsa051680.17987931
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17774929
98HTLV-I infection_Homo sapiens_hsa051660.17764196
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.16084765
100Peroxisome_Homo sapiens_hsa041460.15447313

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