WRAP73

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Studies of the related mouse protein suggest that the encoded protein may play a role in the process of ossification. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.56331278
2L-methionine biosynthetic process from methylthioadenosine (GO:0019509)5.08676292
3establishment of integrated proviral latency (GO:0075713)4.64836707
4cullin deneddylation (GO:0010388)4.54181824
5iron-sulfur cluster assembly (GO:0016226)4.48898670
6proteasome assembly (GO:0043248)4.48699427
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.48055744
8telomere maintenance via semi-conservative replication (GO:0032201)4.40193053
9protein deneddylation (GO:0000338)4.31999342
10deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.27397660
11DNA strand elongation involved in DNA replication (GO:0006271)4.26037968
12energy coupled proton transport, down electrochemical gradient (GO:0015985)4.17910060
13ATP synthesis coupled proton transport (GO:0015986)4.17910060
14negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.13643630
15DNA strand elongation (GO:0022616)4.00668023
16establishment of viral latency (GO:0019043)3.98312625
17male meiosis I (GO:0007141)3.93786301
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.88348821
19NADH dehydrogenase complex assembly (GO:0010257)3.88348821
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.88348821
21L-methionine salvage (GO:0071267)3.86474603
22L-methionine biosynthetic process (GO:0071265)3.86474603
23amino acid salvage (GO:0043102)3.86474603
24chaperone-mediated protein transport (GO:0072321)3.86140704
25negative regulation of ligase activity (GO:0051352)3.85277617
26negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.85277617
27Arp2/3 complex-mediated actin nucleation (GO:0034314)3.78665564
28formation of translation preinitiation complex (GO:0001731)3.74241375
29oxidative phosphorylation (GO:0006119)3.70413678
30telomere maintenance via recombination (GO:0000722)3.69595038
31regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.67170794
32anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.66092870
33positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.62609692
34base-excision repair, AP site formation (GO:0006285)3.61871954
35regulation of cellular amino acid metabolic process (GO:0006521)3.60132019
36ribosomal small subunit assembly (GO:0000028)3.59986346
37mitochondrial respiratory chain complex assembly (GO:0033108)3.59477691
38protein complex biogenesis (GO:0070271)3.59245206
39DNA replication initiation (GO:0006270)3.54563874
40regulation of double-strand break repair via homologous recombination (GO:0010569)3.54437171
41DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.52970772
42exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.51881273
43deoxyribose phosphate biosynthetic process (GO:0046385)3.50323077
442-deoxyribonucleotide biosynthetic process (GO:0009265)3.50323077
45meiosis I (GO:0007127)3.49710282
46intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.49037355
47signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.49037355
48nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.46793772
49DNA unwinding involved in DNA replication (GO:0006268)3.44423519
50signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.44298191
51signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.44298191
52signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.44298191
53DNA replication checkpoint (GO:0000076)3.41699254
54nucleotide-excision repair, DNA gap filling (GO:0006297)3.39959370
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.38740983
56signal transduction involved in DNA damage checkpoint (GO:0072422)3.36536408
57signal transduction involved in DNA integrity checkpoint (GO:0072401)3.36536408
58signal transduction involved in cell cycle checkpoint (GO:0072395)3.36356759
59somatic diversification of immune receptors via somatic mutation (GO:0002566)3.35015141
60somatic hypermutation of immunoglobulin genes (GO:0016446)3.35015141
61ribosome biogenesis (GO:0042254)3.31997521
62mitotic recombination (GO:0006312)3.31021478
63mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.23398341
64attachment of spindle microtubules to kinetochore (GO:0008608)3.23344734
65DNA replication-dependent nucleosome assembly (GO:0006335)3.23005361
66DNA replication-dependent nucleosome organization (GO:0034723)3.23005361
67spliceosomal tri-snRNP complex assembly (GO:0000244)3.22599957
68nucleoside transmembrane transport (GO:1901642)3.22108067
69pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.21904668
70deoxyribonucleotide biosynthetic process (GO:0009263)3.18814609
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.18179479
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.18179479
73positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.17857657
74nucleobase biosynthetic process (GO:0046112)3.17593105
75antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.17392228
76spliceosomal snRNP assembly (GO:0000387)3.17096463
77protein-cofactor linkage (GO:0018065)3.13611150
78negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.12592712
79positive regulation of ligase activity (GO:0051351)3.11597431
80mannose metabolic process (GO:0006013)3.10110966
81pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.07454384
82telomere maintenance via telomere lengthening (GO:0010833)3.06536965
83regulation of mitochondrial translation (GO:0070129)3.06412786
84transcription-coupled nucleotide-excision repair (GO:0006283)3.05836001
85protein targeting to mitochondrion (GO:0006626)3.02137526
86negative regulation of DNA-templated transcription, elongation (GO:0032785)3.00969165
87pseudouridine synthesis (GO:0001522)3.00937105
88respiratory electron transport chain (GO:0022904)3.00111393
89pyrimidine nucleotide catabolic process (GO:0006244)2.99710773
90regulation of ubiquitin-protein transferase activity (GO:0051438)2.98965181
91termination of RNA polymerase III transcription (GO:0006386)2.97471048
92transcription elongation from RNA polymerase III promoter (GO:0006385)2.97471048
93translational elongation (GO:0006414)2.97010492
94viral transcription (GO:0019083)2.96609519
95GDP-mannose metabolic process (GO:0019673)2.95733864
96pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.95493325
97actin nucleation (GO:0045010)2.95010760
98regulation of ligase activity (GO:0051340)2.94541049
99establishment of protein localization to mitochondrion (GO:0072655)2.94381764
100CENP-A containing nucleosome assembly (GO:0034080)2.93345984
101electron transport chain (GO:0022900)2.92634718
102negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.92450330
103synaptonemal complex assembly (GO:0007130)2.91755021
104chromosome organization involved in meiosis (GO:0070192)2.91307659
105ribosomal small subunit biogenesis (GO:0042274)2.90028216
106translational termination (GO:0006415)2.89919913
107G1/S transition of mitotic cell cycle (GO:0000082)2.89362330
108cell cycle G1/S phase transition (GO:0044843)2.89362330
109histone H2A acetylation (GO:0043968)2.88442736
110ribosomal large subunit biogenesis (GO:0042273)2.88016748
111DNA synthesis involved in DNA repair (GO:0000731)2.87580474
1127-methylguanosine mRNA capping (GO:0006370)2.87235579
113methionine biosynthetic process (GO:0009086)2.84550398
114snRNA processing (GO:0016180)2.84003225
115purine nucleobase biosynthetic process (GO:0009113)2.83580343
116mitochondrial RNA metabolic process (GO:0000959)2.83355652
117DNA methylation involved in gamete generation (GO:0043046)2.82755378
118tRNA modification (GO:0006400)2.82488360
1197-methylguanosine RNA capping (GO:0009452)2.80946441
120RNA capping (GO:0036260)2.80946441
121cotranslational protein targeting to membrane (GO:0006613)2.79034860
122SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.78580841
123synapsis (GO:0007129)2.78368869
124meiotic nuclear division (GO:0007126)2.78305417
125DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.78156653
126viral mRNA export from host cell nucleus (GO:0046784)2.77894017
127piRNA metabolic process (GO:0034587)2.77474126
128metallo-sulfur cluster assembly (GO:0031163)2.77076193
129NIK/NF-kappaB signaling (GO:0038061)2.77053728
130negative regulation of mRNA processing (GO:0050686)2.75832386
131regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.71269878
132positive regulation of gamma-delta T cell activation (GO:0046645)2.69183669
133peptidyl-arginine omega-N-methylation (GO:0035247)2.68838770
134negative regulation of telomere maintenance (GO:0032205)2.68780786
135nucleoside transport (GO:0015858)2.68167485
136negative regulation of RNA splicing (GO:0033119)2.68000863
137ncRNA 3-end processing (GO:0043628)2.66432472
138positive regulation of T cell apoptotic process (GO:0070234)2.65761028
139negative regulation of B cell apoptotic process (GO:0002903)2.65533076
140RNA modification (GO:0009451)2.60150140
141meiotic chromosome segregation (GO:0045132)2.60071485
142transcription from mitochondrial promoter (GO:0006390)2.59036224
143pyrimidine-containing compound salvage (GO:0008655)2.58521677
144pyrimidine nucleoside salvage (GO:0043097)2.58521677
145negative regulation of mRNA metabolic process (GO:1903312)2.57616501
146RNA methylation (GO:0001510)2.56639541
147tRNA processing (GO:0008033)2.53980376
148response to peptidoglycan (GO:0032494)2.53871913
149deoxyribonucleotide catabolic process (GO:0009264)2.51554281
150nucleotide salvage (GO:0043173)2.50282225
151ribonucleoprotein complex biogenesis (GO:0022613)2.49874357
152base-excision repair (GO:0006284)2.49771726
153positive regulation of protein homooligomerization (GO:0032464)2.49323723
154histone H3-K36 demethylation (GO:0070544)2.48567695
155negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.48063624
156pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.47709371
157tRNA metabolic process (GO:0006399)2.47445850
158synaptonemal complex organization (GO:0070193)2.46136213
159tRNA aminoacylation for protein translation (GO:0006418)2.46129358
160microtubule nucleation (GO:0007020)2.45791530
161deoxyribose phosphate catabolic process (GO:0046386)2.42521799
162nucleoside salvage (GO:0043174)2.41626187
163rRNA modification (GO:0000154)2.40129445
164positive regulation by symbiont of host defense response (GO:0052509)2.39838979
165modulation by symbiont of host defense response (GO:0052031)2.39838979
166modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.39838979
167modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.39838979
168positive regulation by organism of defense response of other organism involved in symbiotic interact2.39838979
169modulation by symbiont of host immune response (GO:0052553)2.39838979
170purine deoxyribonucleotide catabolic process (GO:0009155)2.39020285
171rRNA transcription (GO:0009303)2.37403882
172amino acid activation (GO:0043038)2.36422874
173tRNA aminoacylation (GO:0043039)2.36422874
174termination of RNA polymerase II transcription (GO:0006369)2.36163998
175guanosine-containing compound biosynthetic process (GO:1901070)2.33293917
176pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.32930431
177coenzyme A biosynthetic process (GO:0015937)2.32922728
178pentose metabolic process (GO:0019321)2.32758791
179GMP metabolic process (GO:0046037)2.32376538
180mitochondrion transport along microtubule (GO:0047497)2.30913400
181establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.30913400

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.50280722
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.29628186
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.05427402
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.78482702
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.74415853
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.72774942
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.66443620
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.58093988
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.46464268
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.43971488
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.20450883
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.91233873
13THAP11_20581084_ChIP-Seq_MESCs_Mouse2.82592164
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.77468853
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.73631274
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.72421003
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61149764
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.56317581
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.51778680
20VDR_23849224_ChIP-Seq_CD4+_Human2.49692071
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.43488720
22XRN2_22483619_ChIP-Seq_HELA_Human2.42372102
23DCP1A_22483619_ChIP-Seq_HELA_Human2.38724170
24FOXP3_21729870_ChIP-Seq_TREG_Human2.34500974
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.26623317
26SRF_21415370_ChIP-Seq_HL-1_Mouse2.25266771
27GABP_19822575_ChIP-Seq_HepG2_Human2.23814390
28RBPJ_22232070_ChIP-Seq_NCS_Mouse2.18719314
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14559795
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.12959148
31E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12444827
32YY1_21170310_ChIP-Seq_MESCs_Mouse2.11028819
33FOXM1_23109430_ChIP-Seq_U2OS_Human2.02552927
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98464426
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.90494324
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.83638475
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81592542
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81179093
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79987331
40TTF2_22483619_ChIP-Seq_HELA_Human1.74584380
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.74423118
42CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.69025368
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67903687
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.66703181
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65283904
46CIITA_25753668_ChIP-Seq_RAJI_Human1.63811428
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.63718458
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.62576629
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.60495391
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59783395
51MAF_26560356_Chip-Seq_TH2_Human1.59527001
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57778472
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56771930
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54899750
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.51439971
56SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.47441316
57KDM5A_27292631_Chip-Seq_BREAST_Human1.46614429
58BCL6_27268052_Chip-Seq_Bcells_Human1.41965697
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40885268
60MYC_22102868_ChIP-Seq_BL_Human1.40003475
61CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39149651
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.38734739
63ELK1_19687146_ChIP-ChIP_HELA_Human1.37569369
64P68_20966046_ChIP-Seq_HELA_Human1.37392540
65MAF_26560356_Chip-Seq_TH1_Human1.35457816
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.34234412
67BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.33991359
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33410452
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29301342
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.29260859
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29056465
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.29035993
73BCOR_27268052_Chip-Seq_Bcells_Human1.26615065
74UTX_26944678_Chip-Seq_JUKART_Human1.24709250
75YY1_22570637_ChIP-Seq_MALME-3M_Human1.24064956
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22133543
77PHF8_20622854_ChIP-Seq_HELA_Human1.20728266
78MYC_18940864_ChIP-ChIP_HL60_Human1.20353848
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19740816
80TET1_21451524_ChIP-Seq_MESCs_Mouse1.18769722
81AR_21909140_ChIP-Seq_LNCAP_Human1.15499022
82KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15256333
83E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15241780
84NCOR1_26117541_ChIP-Seq_K562_Human1.15234876
85TFEB_21752829_ChIP-Seq_HELA_Human1.14626899
86CTCF_26484167_Chip-Seq_Bcells_Mouse1.13349129
87VDR_21846776_ChIP-Seq_THP-1_Human1.11291011
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10853464
89E2F1_20622854_ChIP-Seq_HELA_Human1.10038282
90LXR_22292898_ChIP-Seq_THP-1_Human1.09067993
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07811833
92CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07614965
93IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.05772861
94CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.04921116
95NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04481937
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04054845
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02460976
98EGR1_19374776_ChIP-ChIP_THP-1_Human1.02230987
99SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01572583
100ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00898434
101SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00698799
102SPI1_23547873_ChIP-Seq_NB4_Human0.99432112
103EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99422230
104FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99416835
105CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95649636
106CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94747701
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92473595
108KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90770664
109TBX5_21415370_ChIP-Seq_HL-1_Mouse0.90519243
110CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89976926
111FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89326926
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88370579
113KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87527534
114CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87346313
115RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.85370215
116ELK1_22589737_ChIP-Seq_MCF10A_Human0.85110782
117POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84762899
118CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.84029372
119SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82775925
120FOXP1_21924763_ChIP-Seq_HESCs_Human0.80331566
121MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.79393360
122CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.77119498
123CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.76354340

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.80499403
2MP0003693_abnormal_embryo_hatching3.28855297
3MP0010094_abnormal_chromosome_stability3.26040715
4MP0008058_abnormal_DNA_repair2.81875302
5MP0008995_early_reproductive_senescence2.72105549
6MP0003077_abnormal_cell_cycle2.69038462
7MP0004957_abnormal_blastocyst_morpholog2.63493451
8MP0008007_abnormal_cellular_replicative2.60697412
9MP0003111_abnormal_nucleus_morphology2.55695219
10MP0003656_abnormal_erythrocyte_physiolo2.55465819
11MP0001529_abnormal_vocalization2.53311451
12MP0004147_increased_porphyrin_level2.43529548
13MP0008877_abnormal_DNA_methylation2.39151642
14MP0006036_abnormal_mitochondrial_physio2.37279264
15MP0003806_abnormal_nucleotide_metabolis2.29646822
16MP0002396_abnormal_hematopoietic_system2.24357383
17MP0002163_abnormal_gland_morphology1.89415204
18MP0004859_abnormal_synaptic_plasticity1.87926253
19MP0006035_abnormal_mitochondrial_morpho1.84823343
20MP0005451_abnormal_body_composition1.78400929
21MP0003879_abnormal_hair_cell1.78360240
22MP0005671_abnormal_response_to1.78162456
23MP0008057_abnormal_DNA_replication1.77064201
24MP0000372_irregular_coat_pigmentation1.73663694
25MP0002736_abnormal_nociception_after1.70573827
26MP0009046_muscle_twitch1.67341580
27MP0002064_seizures1.67177953
28MP0003635_abnormal_synaptic_transmissio1.65170025
29MP0003763_abnormal_thymus_physiology1.63939628
30MP0001905_abnormal_dopamine_level1.62688665
31MP0002398_abnormal_bone_marrow1.61686772
32MP0002272_abnormal_nervous_system1.60750281
33MP0003436_decreased_susceptibility_to1.60346855
34MP0004142_abnormal_muscle_tone1.59617903
35MP0005645_abnormal_hypothalamus_physiol1.58596148
36MP0000678_abnormal_parathyroid_gland1.56099809
37MP0000685_abnormal_immune_system1.55908376
38MP0008932_abnormal_embryonic_tissue1.54733426
39MP0001968_abnormal_touch/_nociception1.52109149
40MP0002210_abnormal_sex_determination1.49455247
41MP0009333_abnormal_splenocyte_physiolog1.48120481
42MP0005387_immune_system_phenotype1.44094904
43MP0001790_abnormal_immune_system1.44094904
44MP0006292_abnormal_olfactory_placode1.43091264
45MP0001929_abnormal_gametogenesis1.40789137
46MP0001986_abnormal_taste_sensitivity1.40554566
47MP0000689_abnormal_spleen_morphology1.37421635
48MP0001730_embryonic_growth_arrest1.35613285
49MP0000703_abnormal_thymus_morphology1.33868029
50MP0005058_abnormal_lysosome_morphology1.33232027
51MP0005025_abnormal_response_to1.31453595
52MP0009278_abnormal_bone_marrow1.30683329
53MP0009745_abnormal_behavioral_response1.30283583
54MP0002653_abnormal_ependyma_morphology1.29612731
55MP0002722_abnormal_immune_system1.28753622
56MP0001764_abnormal_homeostasis1.25887144
57MP0002063_abnormal_learning/memory/cond1.24389610
58MP0000313_abnormal_cell_death1.23706690
59MP0006276_abnormal_autonomic_nervous1.22518442
60MP0001145_abnormal_male_reproductive1.21929460
61MP0005397_hematopoietic_system_phenotyp1.21783270
62MP0001545_abnormal_hematopoietic_system1.21783270
63MP0005423_abnormal_somatic_nervous1.21122348
64MP0008789_abnormal_olfactory_epithelium1.20984384
65MP0000350_abnormal_cell_proliferation1.20935089
66MP0003786_premature_aging1.19985211
67MP0000013_abnormal_adipose_tissue1.18744482
68MP0001800_abnormal_humoral_immune1.17992274
69MP0008872_abnormal_physiological_respon1.17257013
70MP0002429_abnormal_blood_cell1.16824491
71MP0004270_analgesia1.16821508
72MP0003172_abnormal_lysosome_physiology1.16281445
73MP0005499_abnormal_olfactory_system1.14619281
74MP0000015_abnormal_ear_pigmentation1.14533200
75MP0002405_respiratory_system_inflammati1.14342584
76MP0010307_abnormal_tumor_latency1.12695190
77MP0003329_amyloid_beta_deposits1.11479587
78MP0000716_abnormal_immune_system1.11254090
79MP0008569_lethality_at_weaning1.09355974
80MP0001873_stomach_inflammation1.07979554
81MP0003698_abnormal_male_reproductive1.06564098
82MP0002420_abnormal_adaptive_immunity1.04859827
83MP0002572_abnormal_emotion/affect_behav1.04757292
84MP0004808_abnormal_hematopoietic_stem1.04681845
85MP0002019_abnormal_tumor_incidence1.04303081
86MP0002160_abnormal_reproductive_system1.02989104
87MP0003221_abnormal_cardiomyocyte_apopto1.02520654
88MP0001440_abnormal_grooming_behavior1.01292649
89MP0000653_abnormal_sex_gland1.00638085
90MP0001819_abnormal_immune_cell1.00547452
91MP0002184_abnormal_innervation1.00510979
92MP0006054_spinal_hemorrhage0.99360302
93MP0002132_abnormal_respiratory_system0.96746949
94MP0004811_abnormal_neuron_physiology0.95671897
95MP0001835_abnormal_antigen_presentation0.95343076
96MP0002723_abnormal_immune_serum0.95296382
97MP0003866_abnormal_defecation0.94948117
98MP0008260_abnormal_autophagy0.93625463
99MP0002080_prenatal_lethality0.92453845
100MP0000358_abnormal_cell_content/0.92178508
101MP0002067_abnormal_sensory_capabilities0.91535516
102MP0000681_abnormal_thyroid_gland0.91508841
103MP0001188_hyperpigmentation0.91433877
104MP0002419_abnormal_innate_immunity0.91286698
105MP0004133_heterotaxia0.90868517
106MP0003122_maternal_imprinting0.90215467
107MP0009765_abnormal_xenobiotic_induced0.87970239
108MP0009785_altered_susceptibility_to0.87239121
109MP0009379_abnormal_foot_pigmentation0.86489647
110MP0002452_abnormal_antigen_presenting0.86333126
111MP0002095_abnormal_skin_pigmentation0.86136306
112MP0002734_abnormal_mechanical_nocicepti0.85623203
113MP0001853_heart_inflammation0.85352190
114MP0004215_abnormal_myocardial_fiber0.84397126
115MP0009697_abnormal_copulation0.83636052
116MP0000490_abnormal_crypts_of0.83200851
117MP0003123_paternal_imprinting0.81710484
118MP0005464_abnormal_platelet_physiology0.80797800
119MP0005389_reproductive_system_phenotype0.79531887
120MP0000858_altered_metastatic_potential0.78437055
121MP0005266_abnormal_metabolism0.78376377
122MP0002083_premature_death0.78293399
123MP0003943_abnormal_hepatobiliary_system0.77822120
124MP0005000_abnormal_immune_tolerance0.77801013
125MP0005075_abnormal_melanosome_morpholog0.77505944
126MP0002148_abnormal_hypersensitivity_rea0.76786379
127MP0003718_maternal_effect0.76709969
128MP0002102_abnormal_ear_morphology0.76461712
129MP0002249_abnormal_larynx_morphology0.75867628
130MP0001697_abnormal_embryo_size0.75517230
131MP0005386_behavior/neurological_phenoty0.75280371
132MP0004924_abnormal_behavior0.75280371
133MP0003303_peritoneal_inflammation0.74913990
134MP0000749_muscle_degeneration0.74609410
135MP0002735_abnormal_chemical_nociception0.73599903
136MP0004145_abnormal_muscle_electrophysio0.73572769
137MP0003646_muscle_fatigue0.72886202
138MP0002066_abnormal_motor_capabilities/c0.72643752
139MP0002229_neurodegeneration0.72427680
140MP0006072_abnormal_retinal_apoptosis0.71903325
141MP0002166_altered_tumor_susceptibility0.71456301
142MP0003315_abnormal_perineum_morphology0.71336572
143MP0000747_muscle_weakness0.71195701
144MP0001119_abnormal_female_reproductive0.71093191
145MP0005394_taste/olfaction_phenotype0.70839232
146MP0009840_abnormal_foam_cell0.70146317
147MP0001727_abnormal_embryo_implantation0.68821829
148MP0004381_abnormal_hair_follicle0.68117269
149MP0004742_abnormal_vestibular_system0.63418241

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.56754415
2Abnormal mitochondria in muscle tissue (HP:0008316)4.36778839
3Hepatocellular necrosis (HP:0001404)4.35912005
4Mitochondrial inheritance (HP:0001427)4.27958192
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.15358436
6Decreased activity of mitochondrial respiratory chain (HP:0008972)4.15358436
7Cerebral hypomyelination (HP:0006808)4.12368022
8Increased CSF lactate (HP:0002490)3.89266502
93-Methylglutaconic aciduria (HP:0003535)3.84477779
10Abnormality of glycolysis (HP:0004366)3.74547162
11Increased serum pyruvate (HP:0003542)3.74547162
12Aplastic anemia (HP:0001915)3.67233623
13Abnormality of the heme biosynthetic pathway (HP:0010472)3.67196188
14Acute encephalopathy (HP:0006846)3.66304520
15Abnormality of cells of the erythroid lineage (HP:0012130)3.57786799
16Abnormal number of erythroid precursors (HP:0012131)3.56778753
17Hepatic necrosis (HP:0002605)3.53628525
18Progressive macrocephaly (HP:0004481)3.51352270
19Neuroendocrine neoplasm (HP:0100634)3.28511870
20Increased serum lactate (HP:0002151)3.13167086
21Abnormality of the aortic arch (HP:0012303)3.12032292
22Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.11891819
23Birth length less than 3rd percentile (HP:0003561)3.06717560
24Broad distal phalanx of finger (HP:0009836)2.94467088
25Medulloblastoma (HP:0002885)2.93531691
26Lactic acidosis (HP:0003128)2.91762025
27Agnosia (HP:0010524)2.90888267
28Recurrent cutaneous fungal infections (HP:0011370)2.90124539
29Chronic mucocutaneous candidiasis (HP:0002728)2.90124539
30Poor head control (HP:0002421)2.79993479
31Increased hepatocellular lipid droplets (HP:0006565)2.78679956
32Recurrent fungal infections (HP:0002841)2.75162540
33Leukodystrophy (HP:0002415)2.74011453
34Optic nerve coloboma (HP:0000588)2.69303515
35Microvesicular hepatic steatosis (HP:0001414)2.67877767
36CNS demyelination (HP:0007305)2.62431071
37Emotional lability (HP:0000712)2.60550833
38Panhypogammaglobulinemia (HP:0003139)2.60406059
39Respiratory failure (HP:0002878)2.58950251
40Colon cancer (HP:0003003)2.57837034
41Chronic obstructive pulmonary disease (HP:0006510)2.53024166
42Obstructive lung disease (HP:0006536)2.53024166
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.51669092
44Squamous cell carcinoma (HP:0002860)2.51547320
45Postnatal microcephaly (HP:0005484)2.46591232
46Stomatitis (HP:0010280)2.45834264
47Mediastinal lymphadenopathy (HP:0100721)2.45826362
48Lipid accumulation in hepatocytes (HP:0006561)2.45662540
49Exercise intolerance (HP:0003546)2.45131984
50Pheochromocytoma (HP:0002666)2.44960041
51Hypertensive crisis (HP:0100735)2.44449194
52CNS hypomyelination (HP:0003429)2.41570731
53Abnormality of DNA repair (HP:0003254)2.41170025
54Delusions (HP:0000746)2.38697019
55Unsteady gait (HP:0002317)2.36520069
56Chromsome breakage (HP:0040012)2.35678927
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.31521229
58Abnormality of T cell physiology (HP:0011840)2.31036282
59Eczematoid dermatitis (HP:0000976)2.25335885
60Increased intramyocellular lipid droplets (HP:0012240)2.24989715
61Increased IgM level (HP:0003496)2.24180120
62Cerebral edema (HP:0002181)2.23399828
63Recurrent bacterial skin infections (HP:0005406)2.20405440
64Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.20054512
65Abnormality of lateral ventricle (HP:0030047)2.17402600
66Absent rod-and cone-mediated responses on ERG (HP:0007688)2.17387852
67Truncus arteriosus (HP:0001660)2.17343367
68Duplicated collecting system (HP:0000081)2.16299514
69Abnormality of cochlea (HP:0000375)2.15950122
70Respiratory difficulties (HP:0002880)2.15713102
71Abnormal delayed hypersensitivity skin test (HP:0002963)2.15679196
72Abnormality of the renal collecting system (HP:0004742)2.14334449
73Recurrent abscess formation (HP:0002722)2.12858066
74Prominent metopic ridge (HP:0005487)2.09835934
75Cholecystitis (HP:0001082)2.09062285
76Abnormal gallbladder physiology (HP:0012438)2.09062285
77Hyperthyroidism (HP:0000836)2.08643918
78Abnormal lung lobation (HP:0002101)2.08423492
79Aplasia/Hypoplasia of the patella (HP:0006498)2.07851147
80Pancytopenia (HP:0001876)2.07105393
81Focal motor seizures (HP:0011153)2.06873973
82Patellar aplasia (HP:0006443)2.06385513
83Acute hepatic failure (HP:0006554)2.06332810
84Combined immunodeficiency (HP:0005387)2.05278481
85Granulocytopenia (HP:0001913)2.04497599
86Progressive muscle weakness (HP:0003323)2.04458140
87Hypoplasia of the pons (HP:0012110)2.03628060
88Primitive neuroectodermal tumor (HP:0030065)2.03078542
89Neuroblastic tumors (HP:0004376)2.03078542
90Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.03078542
91Neuroblastoma (HP:0003006)2.03078542
92Abnormality of the labia minora (HP:0012880)2.01503048
93Oral leukoplakia (HP:0002745)2.00563304
94Optic disc pallor (HP:0000543)2.00145087
95Macrocytic anemia (HP:0001972)1.97185402
96Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96942842
97Exertional dyspnea (HP:0002875)1.96633018
98Pallor (HP:0000980)1.96206769
99Seborrheic dermatitis (HP:0001051)1.96134576
100Abnormality of T cells (HP:0002843)1.96052009
101Renal Fanconi syndrome (HP:0001994)1.96045007
102Trismus (HP:0000211)1.95709994
103Long palpebral fissure (HP:0000637)1.95130618
104Ependymoma (HP:0002888)1.94033630
105Limb hypertonia (HP:0002509)1.93686030
106Premature graying of hair (HP:0002216)1.90936075
107IgG deficiency (HP:0004315)1.90924648
108Breast hypoplasia (HP:0003187)1.90452908
109Facial hemangioma (HP:0000329)1.89758001
110Ragged-red muscle fibers (HP:0003200)1.89416322
111Abnormality of the pons (HP:0007361)1.88657303
112Abnormality of reticulocytes (HP:0004312)1.88540182
113Recurrent skin infections (HP:0001581)1.88060474
114Large eyes (HP:0001090)1.88003015
115IgM deficiency (HP:0002850)1.87925230
116Aplasia/Hypoplasia of the thymus (HP:0010515)1.87237490
117Recurrent viral infections (HP:0004429)1.86935427
118Neutropenia (HP:0001875)1.86778625
119Atonic seizures (HP:0010819)1.86691789
120Rough bone trabeculation (HP:0100670)1.85498018
121Acute lymphatic leukemia (HP:0006721)1.85122708
122Gastrointestinal infarctions (HP:0005244)1.84959816
123Abnormality of the metopic suture (HP:0005556)1.84651187
124Recurrent bronchitis (HP:0002837)1.84176343
125Abnormality of pyrimidine metabolism (HP:0004353)1.84058329
126Hypoplastic pelvis (HP:0008839)1.83629941
127Poor suck (HP:0002033)1.83555530
128Reticulocytopenia (HP:0001896)1.83524358
129Elevated erythrocyte sedimentation rate (HP:0003565)1.82664017
130Petechiae (HP:0000967)1.82535799
131Truncal ataxia (HP:0002078)1.82003876
132Epileptic encephalopathy (HP:0200134)1.81529520
13311 pairs of ribs (HP:0000878)1.81380145
134Microretrognathia (HP:0000308)1.81376803
135Meningitis (HP:0001287)1.81318070
136Horseshoe kidney (HP:0000085)1.79308570
137Abnormality of macrophages (HP:0004311)1.78140631
138Neoplasm of the peripheral nervous system (HP:0100007)1.78064821
139Increased muscle lipid content (HP:0009058)1.77799901
140Severe visual impairment (HP:0001141)1.77235101
141Progressive microcephaly (HP:0000253)1.76612993
142Selective tooth agenesis (HP:0001592)1.74661269
143Bone marrow hypocellularity (HP:0005528)1.74311022
144Basal cell carcinoma (HP:0002671)1.74176120
145Gastrointestinal inflammation (HP:0004386)1.74164538
146Nephroblastoma (Wilms tumor) (HP:0002667)1.73591719
147Methylmalonic aciduria (HP:0012120)1.73505109
148Ureteral duplication (HP:0000073)1.73306252
149Absent thumb (HP:0009777)1.72341839
150Fatigue (HP:0012378)1.70205755
151Abnormality of B cell number (HP:0010975)1.69177889
152B lymphocytopenia (HP:0010976)1.69177889
153Visual hallucinations (HP:0002367)1.69030930
154Severe combined immunodeficiency (HP:0004430)1.68886433
155Abnormality of the preputium (HP:0100587)1.68866307
156Type 2 muscle fiber atrophy (HP:0003554)1.68837958
157Absence seizures (HP:0002121)1.67364633
158Long foot (HP:0001833)1.66351987
159Abnormality of dicarboxylic acid metabolism (HP:0010995)1.66306356
160Dicarboxylic aciduria (HP:0003215)1.66306356
161Cutaneous photosensitivity (HP:0000992)1.65281166
162Lymphopenia (HP:0001888)1.63749870
163Limb ataxia (HP:0002070)1.60425711
164Progressive inability to walk (HP:0002505)1.59257661
165Type I transferrin isoform profile (HP:0003642)1.58782787
166Opisthotonus (HP:0002179)1.58601854
167Gliosis (HP:0002171)1.56607473
168Lymphoma (HP:0002665)1.56164245
169Embryonal renal neoplasm (HP:0011794)1.55808548

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.86357372
2TAOK35.08480240
3CDK193.29455595
4STK163.00198958
5EEF2K2.85917796
6WEE12.85730161
7MAP3K122.72163628
8DAPK12.51785505
9MAP2K32.47014030
10TSSK62.43262521
11DAPK22.42477230
12CCNB12.37885878
13TESK22.32203562
14VRK12.27704018
15CDC72.25907729
16BCKDK2.21920446
17EIF2AK12.20607711
18LIMK12.01223264
19ERN12.00669176
20SRPK11.94313294
21IRAK41.89752453
22NME21.89719441
23CASK1.87122195
24MAPKAPK31.86608275
25ARAF1.78731641
26SMG11.78136075
27PRPF4B1.62195716
28DYRK1B1.59852468
29MAP4K21.58409453
30PRKD21.57468720
31TNK21.55970615
32ACVR1B1.52123369
33MAP4K11.49488342
34SIK31.47008248
35BRSK11.43373994
36TLK11.39565537
37MAPK131.38421444
38TXK1.37882815
39IRAK31.37197835
40PIM21.37036516
41BRAF1.29382008
42MAPKAPK51.26347156
43TAOK11.26211372
44BRSK21.22682495
45EPHB11.19414506
46EPHA31.14624950
47SCYL21.14572077
48EIF2AK31.10414372
49DAPK31.08868633
50MAPK111.07635256
51TESK11.06280213
52MAP3K101.04898254
53AURKA1.03343169
54KSR11.03192569
55MAP3K71.02913162
56RIPK41.01729978
57PLK40.97572746
58NME10.97466596
59TAOK20.96855961
60MARK30.96791635
61UHMK10.96574744
62DYRK30.96031391
63GRK60.95867463
64ICK0.94220321
65RPS6KB20.93231520
66CHEK20.91470125
67PIM10.90805679
68MAP2K60.90402663
69CSNK1G30.90203726
70JAK30.88855854
71KSR20.85849388
72CDK11A0.82084316
73MARK20.81381911
74IKBKB0.80034700
75PLK30.79124423
76NEK10.78662789
77SYK0.78384503
78PLK10.76233832
79MAP2K70.75946807
80ATR0.75331140
81PAK40.75317502
82RPS6KA40.74669337
83CDK180.72614910
84MAP3K110.71432529
85HCK0.70958085
86IKBKE0.70559592
87BTK0.70291739
88STK40.70223218
89VRK20.69069693
90PAK10.68747842
91CDK150.68525507
92CSK0.68059137
93CSNK2A20.66980723
94ILK0.66400920
95MYLK0.66317063
96AKT20.65215268
97BLK0.64050035
98OXSR10.64021798
99NEK20.63336335
100BCR0.62948642
101FGR0.62229469
102PAK60.61863751
103CLK10.61478081
104CDK80.61433682
105TEC0.60626299
106TTK0.60320945
107PDPK10.60020036
108MINK10.59990357
109PTK60.58852248
110TGFBR10.58811296
111CDK140.58276385
112AURKB0.58232777
113TNIK0.58142215
114WNK30.58120998
115PRKCG0.56723155
116PDK10.56540150
117MAP3K40.55011072
118ZAP700.55006560
119PLK20.54759298
120PASK0.53847211
121CSNK2A10.52963938
122RPS6KA50.50891649
123PDK20.49584626
124CSF1R0.49551165
125MAP2K40.49275461
126MAP3K80.47890980
127CDK40.46998275
128IRAK20.46017653
129CDK120.45466197
130PRKAA10.44477480
131MST40.44368832
132RAF10.44343601
133KDR0.44161175
134CHEK10.44147663
135ITK0.43865636
136DYRK20.43020376
137SIK20.42424751
138JAK20.42053981
139EPHA40.41120724
140TYK20.40598707
141CSNK1A1L0.38458889
142CAMK2B0.36064162
143PNCK0.35693745
144LYN0.34871969
145GRK50.34256031
146TBK10.33730132
147MAPK120.33713581
148FES0.33543076
149CAMKK20.32982596
150CDK20.32352083
151CDK70.31587426
152LCK0.30664648
153CSNK1G20.29947189
154PRKCI0.29603724
155ROCK20.29535479

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.65625746
2DNA replication_Homo sapiens_hsa030304.55052911
3Mismatch repair_Homo sapiens_hsa034304.09333060
4Ribosome_Homo sapiens_hsa030103.23784911
5Oxidative phosphorylation_Homo sapiens_hsa001903.20543689
6Base excision repair_Homo sapiens_hsa034103.03538583
7Spliceosome_Homo sapiens_hsa030402.96606047
8Parkinsons disease_Homo sapiens_hsa050122.89382657
9RNA polymerase_Homo sapiens_hsa030202.65632407
10Nucleotide excision repair_Homo sapiens_hsa034202.55339358
11Non-homologous end-joining_Homo sapiens_hsa034502.41174232
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.34298111
13Pyrimidine metabolism_Homo sapiens_hsa002402.28815882
14Protein export_Homo sapiens_hsa030602.22341107
15Huntingtons disease_Homo sapiens_hsa050162.15597491
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.08326053
17Alzheimers disease_Homo sapiens_hsa050102.03714039
18RNA transport_Homo sapiens_hsa030132.01182082
19Homologous recombination_Homo sapiens_hsa034402.01149092
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.98717940
21RNA degradation_Homo sapiens_hsa030181.62520217
22Cell cycle_Homo sapiens_hsa041101.59524297
23Regulation of autophagy_Homo sapiens_hsa041401.54249648
24Synaptic vesicle cycle_Homo sapiens_hsa047211.49625882
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44418724
26Steroid biosynthesis_Homo sapiens_hsa001001.42750314
27One carbon pool by folate_Homo sapiens_hsa006701.38933553
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36554953
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34958188
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.30218280
31Purine metabolism_Homo sapiens_hsa002301.28469526
32Collecting duct acid secretion_Homo sapiens_hsa049661.26166898
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20901498
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.20598003
35Primary immunodeficiency_Homo sapiens_hsa053401.19327409
36Sulfur relay system_Homo sapiens_hsa041221.18356028
37Other glycan degradation_Homo sapiens_hsa005111.16088534
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.14417774
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12987756
40Selenocompound metabolism_Homo sapiens_hsa004501.11449664
41Acute myeloid leukemia_Homo sapiens_hsa052211.08083142
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05785662
43Fanconi anemia pathway_Homo sapiens_hsa034601.05001591
44Nicotine addiction_Homo sapiens_hsa050331.03958445
45Measles_Homo sapiens_hsa051621.03320401
46Basal transcription factors_Homo sapiens_hsa030221.02631632
47Folate biosynthesis_Homo sapiens_hsa007901.01565378
48Vibrio cholerae infection_Homo sapiens_hsa051100.94810696
49Cyanoamino acid metabolism_Homo sapiens_hsa004600.93588711
50Systemic lupus erythematosus_Homo sapiens_hsa053220.93473361
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92571488
52Biosynthesis of amino acids_Homo sapiens_hsa012300.92194631
53Pentose phosphate pathway_Homo sapiens_hsa000300.91081988
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.89468609
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88744793
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88296605
57Oocyte meiosis_Homo sapiens_hsa041140.85062477
58Pyruvate metabolism_Homo sapiens_hsa006200.83970136
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83375314
60Cardiac muscle contraction_Homo sapiens_hsa042600.82992015
61mRNA surveillance pathway_Homo sapiens_hsa030150.80161002
62Epstein-Barr virus infection_Homo sapiens_hsa051690.78953507
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78360323
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76360665
65Carbon metabolism_Homo sapiens_hsa012000.75567237
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71999762
67Antigen processing and presentation_Homo sapiens_hsa046120.69081681
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68558041
69Alcoholism_Homo sapiens_hsa050340.67891044
70Autoimmune thyroid disease_Homo sapiens_hsa053200.66303649
71Galactose metabolism_Homo sapiens_hsa000520.63385274
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62331381
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61777088
74Osteoclast differentiation_Homo sapiens_hsa043800.60595368
75Hepatitis B_Homo sapiens_hsa051610.59862572
76Graft-versus-host disease_Homo sapiens_hsa053320.58929607
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58210282
78Fructose and mannose metabolism_Homo sapiens_hsa000510.57552226
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.57540755
80Non-small cell lung cancer_Homo sapiens_hsa052230.54974965
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54550907
82Salmonella infection_Homo sapiens_hsa051320.54378459
83Leishmaniasis_Homo sapiens_hsa051400.54144821
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52273392
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.50342579
86p53 signaling pathway_Homo sapiens_hsa041150.48262606
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47247816
88Metabolic pathways_Homo sapiens_hsa011000.47183599
89Tuberculosis_Homo sapiens_hsa051520.46277839
90Amphetamine addiction_Homo sapiens_hsa050310.45158288
91N-Glycan biosynthesis_Homo sapiens_hsa005100.45092881
92Influenza A_Homo sapiens_hsa051640.44121701
93Long-term potentiation_Homo sapiens_hsa047200.44061483
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43693010
95Fatty acid elongation_Homo sapiens_hsa000620.43169849
96Chronic myeloid leukemia_Homo sapiens_hsa052200.43097594
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42830920
98Viral myocarditis_Homo sapiens_hsa054160.42736638
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42693050
100Morphine addiction_Homo sapiens_hsa050320.42523514
101Glutathione metabolism_Homo sapiens_hsa004800.41541215
102Viral carcinogenesis_Homo sapiens_hsa052030.39926540
103Notch signaling pathway_Homo sapiens_hsa043300.39384792
104Dopaminergic synapse_Homo sapiens_hsa047280.35325677
105mTOR signaling pathway_Homo sapiens_hsa041500.34229855
106VEGF signaling pathway_Homo sapiens_hsa043700.34192126
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33938622
108Jak-STAT signaling pathway_Homo sapiens_hsa046300.33841836
109Shigellosis_Homo sapiens_hsa051310.33270929
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33037351
111Olfactory transduction_Homo sapiens_hsa047400.32114790
112GABAergic synapse_Homo sapiens_hsa047270.32098887
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31693515
114Lysine degradation_Homo sapiens_hsa003100.31384967
115Phototransduction_Homo sapiens_hsa047440.30055788
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27122149
117Type I diabetes mellitus_Homo sapiens_hsa049400.26965889
118Circadian entrainment_Homo sapiens_hsa047130.26355565
119Allograft rejection_Homo sapiens_hsa053300.26083021
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24824999
121Vitamin B6 metabolism_Homo sapiens_hsa007500.24745890
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23290078
123Glutamatergic synapse_Homo sapiens_hsa047240.21596784
124HTLV-I infection_Homo sapiens_hsa051660.20080794
125Phagosome_Homo sapiens_hsa041450.18631392
126T cell receptor signaling pathway_Homo sapiens_hsa046600.18359288
127Legionellosis_Homo sapiens_hsa051340.15775047
128Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.15539451
129Rheumatoid arthritis_Homo sapiens_hsa053230.15439758
130Herpes simplex infection_Homo sapiens_hsa051680.13725851
131Colorectal cancer_Homo sapiens_hsa052100.12963572
132Intestinal immune network for IgA production_Homo sapiens_hsa046720.11913696
133Long-term depression_Homo sapiens_hsa047300.10985027
134B cell receptor signaling pathway_Homo sapiens_hsa046620.07329455
135Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.06823200
136Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.06191462
137Apoptosis_Homo sapiens_hsa042100.04524496

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