WNT11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)5.97717311
2triglyceride catabolic process (GO:0019433)5.43251767
3polarized epithelial cell differentiation (GO:0030859)5.38616648
4establishment of apical/basal cell polarity (GO:0035089)5.10086443
5neutral lipid catabolic process (GO:0046461)4.94683641
6acylglycerol catabolic process (GO:0046464)4.94683641
7regulation of sequestering of triglyceride (GO:0010889)4.90717637
8regulation of cardioblast differentiation (GO:0051890)4.88702483
9muscle filament sliding (GO:0030049)4.78775163
10actin-myosin filament sliding (GO:0033275)4.78775163
11NADH metabolic process (GO:0006734)4.61838646
12cardiac myofibril assembly (GO:0055003)4.52803856
13hair cycle (GO:0042633)4.48362233
14molting cycle (GO:0042303)4.48362233
15endocardial cushion development (GO:0003197)4.39003116
16hemidesmosome assembly (GO:0031581)4.36997072
17atrioventricular valve morphogenesis (GO:0003181)4.31828972
18establishment or maintenance of monopolar cell polarity (GO:0061339)4.27197220
19establishment of monopolar cell polarity (GO:0061162)4.27197220
20peptidyl-proline hydroxylation (GO:0019511)4.19629061
21negative regulation of homotypic cell-cell adhesion (GO:0034111)4.17663787
22actin-mediated cell contraction (GO:0070252)4.11129243
23desmosome organization (GO:0002934)4.09202141
24collagen fibril organization (GO:0030199)3.97566442
25cellular response to epinephrine stimulus (GO:0071872)3.93402889
26NIK/NF-kappaB signaling (GO:0038061)3.88117828
27basement membrane organization (GO:0071711)3.86335703
28myofibril assembly (GO:0030239)3.86160897
29retina vasculature morphogenesis in camera-type eye (GO:0061299)3.83006881
30triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.81006104
31phospholipid homeostasis (GO:0055091)3.75291481
32negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.74606124
33epithelial cell-cell adhesion (GO:0090136)3.74571212
34sarcomere organization (GO:0045214)3.72401310
35negative regulation of striated muscle cell apoptotic process (GO:0010664)3.69408449
36mesenchymal cell proliferation (GO:0010463)3.66780168
37branching involved in salivary gland morphogenesis (GO:0060445)3.64527806
38negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.64509832
39keratan sulfate catabolic process (GO:0042340)3.56584626
40endoderm formation (GO:0001706)3.55936533
41protein heterotrimerization (GO:0070208)3.54929480
42embryonic foregut morphogenesis (GO:0048617)3.49754747
43protein hydroxylation (GO:0018126)3.49186143
44regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.44717101
45regulation of heart morphogenesis (GO:2000826)3.44096667
46cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.43454521
47coronary vasculature morphogenesis (GO:0060977)3.41448300
48negative regulation of norepinephrine secretion (GO:0010700)3.41418989
49plasma lipoprotein particle clearance (GO:0034381)3.40060007
50endodermal cell differentiation (GO:0035987)3.39899803
51glycerolipid catabolic process (GO:0046503)3.36149370
52regulation of glycogen (starch) synthase activity (GO:2000465)3.34756178
53fatty acid homeostasis (GO:0055089)3.34639983
54diacylglycerol metabolic process (GO:0046339)3.34439143
55actin filament-based movement (GO:0030048)3.31374911
56bone trabecula formation (GO:0060346)3.28612383
57response to epinephrine (GO:0071871)3.27899242
58fibril organization (GO:0097435)3.18080172
59chondrocyte development (GO:0002063)3.17616405
60regulation of skeletal muscle contraction (GO:0014819)3.17610936
61regulation of cAMP-dependent protein kinase activity (GO:2000479)3.17021975
62establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.16265499
63regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.15586339
64cardiac right ventricle morphogenesis (GO:0003215)3.15570450
65adherens junction assembly (GO:0034333)3.14871368
66regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.11202573
67regulation of secondary heart field cardioblast proliferation (GO:0003266)3.10537007
68regulation of cardioblast proliferation (GO:0003264)3.10537007
69cell-substrate adherens junction assembly (GO:0007045)3.10292095
70focal adhesion assembly (GO:0048041)3.10292095
71cell migration involved in heart development (GO:0060973)3.09558325
72establishment of epithelial cell polarity (GO:0090162)3.07836232
73regulation of cholesterol storage (GO:0010885)3.07827406
74regulation of mesenchymal cell apoptotic process (GO:2001053)3.07372650
75positive regulation of cell size (GO:0045793)3.07355390
76wound healing, spreading of epidermal cells (GO:0035313)3.07206133
77outflow tract septum morphogenesis (GO:0003148)3.06616784
78triglyceride homeostasis (GO:0070328)3.06237718
79acylglycerol homeostasis (GO:0055090)3.06237718
80negative regulation of fatty acid transport (GO:2000192)3.04471628
81positive regulation of endothelial cell apoptotic process (GO:2000353)3.04070101
82positive regulation of stem cell differentiation (GO:2000738)3.03223046
83cGMP-mediated signaling (GO:0019934)3.03185649
84negative regulation of platelet activation (GO:0010544)3.02910414
85chondrocyte proliferation (GO:0035988)3.02691407
86regulation of cholesterol esterification (GO:0010872)3.01540666
87negative regulation of cell fate specification (GO:0009996)3.00672984
88positive regulation of cellular response to insulin stimulus (GO:1900078)3.00156353
89positive regulation of epithelial to mesenchymal transition (GO:0010718)2.99736853
90cardiac muscle tissue morphogenesis (GO:0055008)2.98641159
91bundle of His cell to Purkinje myocyte communication (GO:0086069)2.98112749
92planar cell polarity pathway involved in neural tube closure (GO:0090179)2.97794247
93regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.97269877
94plasma membrane repair (GO:0001778)2.96803864
95atrial septum morphogenesis (GO:0060413)2.96513268
96positive regulation of cartilage development (GO:0061036)2.96228537
97heart valve morphogenesis (GO:0003179)2.93110563
98positive regulation of vasculogenesis (GO:2001214)2.91858379
99regulation of integrin-mediated signaling pathway (GO:2001044)2.91221854
100regulation of lipoprotein metabolic process (GO:0050746)2.90973151
101mesenchyme morphogenesis (GO:0072132)2.90733993
102actomyosin structure organization (GO:0031032)2.89855117
103positive regulation of BMP signaling pathway (GO:0030513)2.89444027
104embryonic skeletal joint morphogenesis (GO:0060272)2.89379300
105striated muscle hypertrophy (GO:0014897)2.88658439
106regulation of striated muscle cell apoptotic process (GO:0010662)2.87804976
107regulation of macrophage derived foam cell differentiation (GO:0010743)2.86004266
108transcytosis (GO:0045056)2.85925521
109muscle tissue morphogenesis (GO:0060415)2.83833352
110positive regulation of receptor recycling (GO:0001921)2.83753069
111negative regulation of stress fiber assembly (GO:0051497)2.82747654
112skin morphogenesis (GO:0043589)2.81875867
113outer ear morphogenesis (GO:0042473)2.81673772
114positive regulation of insulin receptor signaling pathway (GO:0046628)2.81636852
115lipid particle organization (GO:0034389)2.81501476
116positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.81363671
117dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.81352653
118lymph vessel development (GO:0001945)2.81321247
119glycogen catabolic process (GO:0005980)2.77024508
120regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.76803149
121heart process (GO:0003015)2.76688594
122heart contraction (GO:0060047)2.76688594
123cartilage morphogenesis (GO:0060536)2.76655125
124body morphogenesis (GO:0010171)2.75875922
125substrate adhesion-dependent cell spreading (GO:0034446)2.75459883
126hippo signaling (GO:0035329)2.75037035
127neuron projection extension involved in neuron projection guidance (GO:1902284)2.74717723
128axon extension involved in axon guidance (GO:0048846)2.74717723
129cell proliferation involved in metanephros development (GO:0072203)2.74333274
130cardiac muscle hypertrophy (GO:0003300)2.73992709
131establishment or maintenance of apical/basal cell polarity (GO:0035088)2.73932626
132establishment or maintenance of bipolar cell polarity (GO:0061245)2.73932626
133regulation of p38MAPK cascade (GO:1900744)2.73005447
134cardiac muscle cell development (GO:0055013)2.71968806
1354-hydroxyproline metabolic process (GO:0019471)2.70953458
136* regulation of transforming growth factor beta2 production (GO:0032909)2.70447721
137extracellular matrix disassembly (GO:0022617)2.69991077
138collagen metabolic process (GO:0032963)2.69360619
139lipid storage (GO:0019915)2.69166237
140negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.68790354
141extracellular fibril organization (GO:0043206)2.67874448
142cell-substrate junction assembly (GO:0007044)2.67514304
143endothelium development (GO:0003158)2.67469721
144positive regulation of transcription regulatory region DNA binding (GO:2000679)2.66417368
145positive regulation of lipoprotein lipase activity (GO:0051006)2.66099658
146positive regulation of triglyceride lipase activity (GO:0061365)2.66099658
147triglyceride metabolic process (GO:0006641)2.65959514
148endocrine hormone secretion (GO:0060986)2.64109136
149paraxial mesoderm development (GO:0048339)2.63777434
150muscle cell fate commitment (GO:0042693)2.63430045
151white fat cell differentiation (GO:0050872)2.62908198
152response to water (GO:0009415)2.62465466
153negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.62294913
154fatty acid transmembrane transport (GO:1902001)2.61591529
155triglyceride biosynthetic process (GO:0019432)2.60907331
156positive regulation of Rho protein signal transduction (GO:0035025)2.60882788
157blood coagulation, intrinsic pathway (GO:0007597)2.60521348
158positive regulation of lipid storage (GO:0010884)2.59987113
159glucan catabolic process (GO:0009251)2.59118447
160CDP-diacylglycerol metabolic process (GO:0046341)2.59023403
161phosphatidic acid metabolic process (GO:0046473)2.58194212
162phosphatidic acid biosynthetic process (GO:0006654)2.58194212
163negative regulation of smooth muscle cell proliferation (GO:0048662)2.57114114
164positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.56445282
165positive regulation of glomerulus development (GO:0090193)2.55367841
166barbed-end actin filament capping (GO:0051016)2.54935486
167angiogenesis involved in wound healing (GO:0060055)2.52606412
168regulation of vasculogenesis (GO:2001212)2.52327191
169response to dietary excess (GO:0002021)2.51606267
170cellular response to lithium ion (GO:0071285)2.51394503
171notochord development (GO:0030903)2.51046102
172fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.50832855
173negative regulation of smooth muscle cell migration (GO:0014912)2.50621282
174neutral lipid biosynthetic process (GO:0046460)2.50498371
175acylglycerol biosynthetic process (GO:0046463)2.50498371
176* protein localization to cell surface (GO:0034394)2.49350572
177acylglycerol metabolic process (GO:0006639)2.48596866
178high-density lipoprotein particle remodeling (GO:0034375)2.46953862
179positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.46887562
180neutral lipid metabolic process (GO:0006638)2.46816404
181negative regulation of lipase activity (GO:0060192)2.46799263

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.99966953
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.12027502
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.79436819
4TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.71031860
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.37964295
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.96072902
7HIF1A_21447827_ChIP-Seq_MCF-7_Human2.90984950
8* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.79144774
9CLOCK_20551151_ChIP-Seq_293T_Human2.69611018
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.49312356
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.47702102
12CDX2_20551321_ChIP-Seq_CACO-2_Human2.41471784
13TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.39591508
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.33655262
15EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.31881929
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.28769884
17EP300_21415370_ChIP-Seq_HL-1_Mouse2.20892434
18RXR_22158963_ChIP-Seq_LIVER_Mouse2.15820010
19SALL4_18804426_ChIP-ChIP_XEN_Mouse2.15511347
20WT1_19549856_ChIP-ChIP_CCG9911_Human2.14626593
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.13174829
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.12006935
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.07729484
24ZNF263_19887448_ChIP-Seq_K562_Human2.03564847
25ESR2_21235772_ChIP-Seq_MCF-7_Human2.02950189
26RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.98223868
27PPARA_22158963_ChIP-Seq_LIVER_Mouse1.97255817
28CJUN_26792858_Chip-Seq_BT549_Human1.94625575
29TBX20_22328084_ChIP-Seq_HEART_Mouse1.86429052
30TBX20_22080862_ChIP-Seq_HEART_Mouse1.86429052
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.86275947
32FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.85508436
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.84678414
34* TP53_20018659_ChIP-ChIP_R1E_Mouse1.80283254
35LXR_22158963_ChIP-Seq_LIVER_Mouse1.76439861
36SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.76278852
37SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.76278852
38EGR1_19032775_ChIP-ChIP_M12_Human1.73305139
39SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.71840545
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.70668844
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52707434
42* UBF1/2_26484160_Chip-Seq_HMECs_Human1.50899736
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.49582073
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48321202
45* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.47896332
46* ISL1_27105846_Chip-Seq_CPCs_Mouse1.47727813
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47259509
48* RACK7_27058665_Chip-Seq_MCF-7_Human1.47045892
49PPAR_26484153_Chip-Seq_NCI-H1993_Human1.46854506
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.46294969
51KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44196835
52KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44196835
53KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44196835
54* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44141655
55* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.43454050
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.41740613
57SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37371411
58* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36962622
59* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36962622
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.36764152
61KDM2B_26808549_Chip-Seq_K562_Human1.36642639
62ATF3_27146783_Chip-Seq_COLON_Human1.35117098
63NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.34279500
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.32046999
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29267560
66ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.28865873
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28500986
68P63_26484246_Chip-Seq_KERATINOCYTES_Human1.28152612
69* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27781223
70VDR_24787735_ChIP-Seq_THP-1_Human1.27485935
71NFIB_24661679_ChIP-Seq_LUNG_Mouse1.27101756
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.27026600
73ESR1_20079471_ChIP-ChIP_T-47D_Human1.26126373
74ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.25164082
75BP1_19119308_ChIP-ChIP_Hs578T_Human1.25011071
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23152135
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22520546
78SMC1_22415368_ChIP-Seq_MEFs_Mouse1.22349700
79* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21150131
80* EZH2_27304074_Chip-Seq_ESCs_Mouse1.20982034
81JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20416448
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.19781310
83GATA1_22025678_ChIP-Seq_K562_Human1.19545141
84BRD4_25478319_ChIP-Seq_HGPS_Human1.19409583
85JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19008210
86* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18917199
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18697535
88* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17702526
89SCL_19346495_ChIP-Seq_HPC-7_Human1.17474186
90PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.16927116
91CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16885566
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16207201
93* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15436276
94* SOX2_20726797_ChIP-Seq_SW620_Human1.15324487
95KDM2B_26808549_Chip-Seq_DND41_Human1.14628165
96GATA1_19941826_ChIP-Seq_K562_Human1.14567058
97PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.14181877
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12674211
99ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12184856
100* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11659755
101FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11313687
102TP53_18474530_ChIP-ChIP_U2OS_Human1.10491631
103* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10008244
104STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.08957727
105* GATA4_25053715_ChIP-Seq_YYC3_Human1.08116789
106SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07544501
107RUNX1_27514584_Chip-Seq_MCF-7_Human1.06575993
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05003508
109SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03488367
110SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.03398943
111SMAD_19615063_ChIP-ChIP_OVARY_Human1.03076927
112* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02568566
113* KDM2B_26808549_Chip-Seq_JURKAT_Human1.02481886
114CTCF_27219007_Chip-Seq_Bcells_Human1.02407546
115CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01301301
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00763685
117* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.98973351
118KLF5_25053715_ChIP-Seq_YYC3_Human0.98220774
119* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97994428
120* RING1B_27294783_Chip-Seq_NPCs_Mouse0.97929390
121SMC4_20622854_ChIP-Seq_HELA_Human0.97901446
122ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97481833
123* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96958310
124HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96525707
125* ERG_21242973_ChIP-ChIP_JURKAT_Human0.95884635
126KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95505545
127MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.95380578
128GATA1_19941827_ChIP-Seq_MEL_Mouse0.94577658
129NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94041056
130* RNF2_27304074_Chip-Seq_ESCs_Mouse0.93073060
131RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92975660
132NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92307768
133NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92307768
134SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92187392
135* LXR_22292898_ChIP-Seq_THP-1_Human0.91727335
136TP53_22127205_ChIP-Seq_IMR90_Human0.91482760
137SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.91343164
138EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91187505
139RXR_22108803_ChIP-Seq_LS180_Human0.91168325
140* RING1B_27294783_Chip-Seq_ESCs_Mouse0.90896501
141TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90750403
142PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90626114
143ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90366180
144* GATA6_25053715_ChIP-Seq_YYC3_Human0.88996549
145GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87746619
146TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.87495384
147TP63_22573176_ChIP-Seq_HFKS_Human0.86796039

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose5.19674260
2MP0005275_abnormal_skin_tensile4.27020386
3MP0008438_abnormal_cutaneous_collagen4.20073210
4MP0003705_abnormal_hypodermis_morpholog3.91672157
5MP0005666_abnormal_adipose_tissue3.90569330
6MP0004272_abnormal_basement_membrane3.69237452
7MP0004130_abnormal_muscle_cell3.45814505
8MP0005503_abnormal_tendon_morphology3.25212243
9MP0005623_abnormal_meninges_morphology3.10477998
10MP0005375_adipose_tissue_phenotype2.95165946
11MP0002254_reproductive_system_inflammat2.87794765
12MP0004185_abnormal_adipocyte_glucose2.86674722
13MP0009384_cardiac_valve_regurgitation2.68247722
14MP0002971_abnormal_brown_adipose2.52968595
15MP0004510_myositis2.45658586
16MP0004084_abnormal_cardiac_muscle2.34161284
17MP0002138_abnormal_hepatobiliary_system2.12470754
18MP0000003_abnormal_adipose_tissue2.05294360
19MP0003566_abnormal_cell_adhesion1.96564255
20MP0000749_muscle_degeneration1.95301339
21MP0004264_abnormal_extraembryonic_tissu1.93841028
22MP0009053_abnormal_anal_canal1.90293117
23MP0000751_myopathy1.88206232
24MP0005464_abnormal_platelet_physiology1.85115812
25MP0004858_abnormal_nervous_system1.84845975
26MP0006138_congestive_heart_failure1.81554241
27MP0009115_abnormal_fat_cell1.76355379
28MP0009250_abnormal_appendicular_skeleto1.75664968
29MP0001348_abnormal_lacrimal_gland1.75601322
30MP0003646_muscle_fatigue1.74989755
31MP0003279_aneurysm1.70549133
32MP0010329_abnormal_lipoprotein_level1.67662670
33MP0003385_abnormal_body_wall1.66617469
34MP0003941_abnormal_skin_development1.64267245
35MP0000762_abnormal_tongue_morphology1.64245880
36MP0001958_emphysema1.63602550
37MP0000579_abnormal_nail_morphology1.61710676
38MP0003567_abnormal_fetal_cardiomyocyte1.61007697
39MP0002282_abnormal_trachea_morphology1.60582625
40MP0004036_abnormal_muscle_relaxation1.60264316
41MP0005257_abnormal_intraocular_pressure1.59521143
42MP0003123_paternal_imprinting1.57980753
43MP0010030_abnormal_orbit_morphology1.57751373
44MP0003878_abnormal_ear_physiology1.54439591
45MP0005377_hearing/vestibular/ear_phenot1.54439591
46MP0004087_abnormal_muscle_fiber1.51484858
47MP0001661_extended_life_span1.51415721
48MP0003828_pulmonary_edema1.50065793
49MP0003879_abnormal_hair_cell1.48072777
50MP0002060_abnormal_skin_morphology1.44593270
51MP0000733_abnormal_muscle_development1.43648446
52MP0004215_abnormal_myocardial_fiber1.41506092
53MP0006054_spinal_hemorrhage1.41424093
54MP0001243_abnormal_dermal_layer1.41237441
55MP0005508_abnormal_skeleton_morphology1.40125485
56MP0002970_abnormal_white_adipose1.35832356
57MP0005334_abnormal_fat_pad1.34703185
58* MP0003942_abnormal_urinary_system1.33306813
59MP0002106_abnormal_muscle_physiology1.31622578
60MP0000537_abnormal_urethra_morphology1.31069903
61MP0002972_abnormal_cardiac_muscle1.30222410
62MP0002933_joint_inflammation1.29859532
63MP0005076_abnormal_cell_differentiation1.29463779
64MP0009840_abnormal_foam_cell1.29075292
65MP0010630_abnormal_cardiac_muscle1.28754411
66MP0002009_preneoplasia1.28561034
67MP0000534_abnormal_ureter_morphology1.28333123
68MP0008004_abnormal_stomach_pH1.28062038
69MP0003959_abnormal_lean_body1.27699462
70MP0002098_abnormal_vibrissa_morphology1.27699117
71MP0003122_maternal_imprinting1.26792123
72MP0008775_abnormal_heart_ventricle1.26242184
73MP0000767_abnormal_smooth_muscle1.24406136
74MP0000343_altered_response_to1.23761709
75MP0004145_abnormal_muscle_electrophysio1.23516124
76MP0000049_abnormal_middle_ear1.20247426
77MP0005620_abnormal_muscle_contractility1.18577615
78MP0000163_abnormal_cartilage_morphology1.17639456
79MP0005369_muscle_phenotype1.16246966
80MP0000013_abnormal_adipose_tissue1.16221806
81MP0002127_abnormal_cardiovascular_syste1.15905841
82MP0003115_abnormal_respiratory_system1.14330139
83MP0000759_abnormal_skeletal_muscle1.14276616
84MP0003937_abnormal_limbs/digits/tail_de1.13507491
85MP0005330_cardiomyopathy1.12006124
86MP0001879_abnormal_lymphatic_vessel1.11968763
87MP0005409_darkened_coat_color1.09583069
88MP0002118_abnormal_lipid_homeostasis1.09343541
89MP0002876_abnormal_thyroid_physiology1.09141747
90MP0000750_abnormal_muscle_regeneration1.07853974
91MP0002877_abnormal_melanocyte_morpholog1.07373125
92MP0003091_abnormal_cell_migration1.06860923
93MP0001544_abnormal_cardiovascular_syste1.05869328
94MP0005385_cardiovascular_system_phenoty1.05869328
95MP0002115_abnormal_skeleton_extremities1.05381707
96MP0002234_abnormal_pharynx_morphology1.03698443
97MP0002249_abnormal_larynx_morphology1.03254321
98MP0002108_abnormal_muscle_morphology1.02267125
99MP0005448_abnormal_energy_balance1.00876449
100MP0003011_delayed_dark_adaptation0.99947200
101MP0003191_abnormal_cellular_cholesterol0.99209241
102MP0010234_abnormal_vibrissa_follicle0.97600361
103MP0003868_abnormal_feces_composition0.96742093
104MP0003755_abnormal_palate_morphology0.95924516
105MP0005535_abnormal_body_temperature0.95825062
106MP0004484_altered_response_of0.94966090
107MP0005023_abnormal_wound_healing0.94748186
108MP0009780_abnormal_chondrocyte_physiolo0.94716384
109MP0002166_altered_tumor_susceptibility0.94407827
110MP0010352_gastrointestinal_tract_polyps0.94361395
111MP0000747_muscle_weakness0.93047121
112MP0002796_impaired_skin_barrier0.92058745
113MP0010368_abnormal_lymphatic_system0.91999665
114MP0002269_muscular_atrophy0.91808163
115MP0002295_abnormal_pulmonary_circulatio0.91284509
116MP0002896_abnormal_bone_mineralization0.90946194
117MP0002109_abnormal_limb_morphology0.89109461
118MP0006036_abnormal_mitochondrial_physio0.88838845
119MP0002932_abnormal_joint_morphology0.88326357
120MP0005367_renal/urinary_system_phenotyp0.88239690
121MP0000516_abnormal_urinary_system0.88239690
122MP0002113_abnormal_skeleton_development0.87173328
123MP0005451_abnormal_body_composition0.87100630
124MP0005390_skeleton_phenotype0.85846905
125MP0003724_increased_susceptibility_to0.84731733
126MP0000383_abnormal_hair_follicle0.84403116
127MP0003453_abnormal_keratinocyte_physiol0.84390593
128MP0000377_abnormal_hair_follicle0.83063710
129MP0005058_abnormal_lysosome_morphology0.82507108
130MP0004134_abnormal_chest_morphology0.81175689
131MP0002925_abnormal_cardiovascular_devel0.80591296
132MP0005595_abnormal_vascular_smooth0.80558278
133MP0000249_abnormal_blood_vessel0.79897887
134MP0001175_abnormal_lung_morphology0.78973990
135MP0005501_abnormal_skin_physiology0.78674343
136MP0001270_distended_abdomen0.78665011
137MP0002128_abnormal_blood_circulation0.78017781
138MP0003119_abnormal_digestive_system0.77699501
139MP0003935_abnormal_craniofacial_develop0.76611746
140MP0000230_abnormal_systemic_arterial0.76240547
141MP0002909_abnormal_adrenal_gland0.73459446
142MP0003186_abnormal_redox_activity0.72579527
143MP0000462_abnormal_digestive_system0.71210085
144MP0001614_abnormal_blood_vessel0.68810379
145MP0005083_abnormal_biliary_tract0.65103175
146MP0003638_abnormal_response/metabolism_0.65003247

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.39424251
2Protrusio acetabuli (HP:0003179)4.27376589
3Type 1 muscle fiber predominance (HP:0003803)3.98221825
4Acanthosis nigricans (HP:0000956)3.63333589
5Increased mean platelet volume (HP:0011877)3.56594896
6Exercise-induced muscle cramps (HP:0003710)3.54081004
7Prolonged bleeding time (HP:0003010)3.49478465
8Mesomelia (HP:0003027)3.42023090
9Shallow orbits (HP:0000586)3.38103702
10Oligomenorrhea (HP:0000876)3.33539929
11Menorrhagia (HP:0000132)3.32324239
12Hyperlipoproteinemia (HP:0010980)3.26929326
13Increased connective tissue (HP:0009025)3.26845862
14Right ventricular cardiomyopathy (HP:0011663)3.22640271
15Hypertriglyceridemia (HP:0002155)3.16151621
16Abnormal platelet volume (HP:0011876)3.13519564
17Atrophic scars (HP:0001075)3.08978804
18Epiphyseal dysplasia (HP:0002656)3.00505150
19Cerebral aneurysm (HP:0004944)2.91307647
20Muscle fiber splitting (HP:0003555)2.89183284
21Paralysis (HP:0003470)2.86541751
22Abnormality of dentin (HP:0010299)2.86086324
23Metaphyseal dysplasia (HP:0100255)2.80026390
24Purpura (HP:0000979)2.79713817
25Petechiae (HP:0000967)2.78727052
26Spinal rigidity (HP:0003306)2.78722305
27Sudden death (HP:0001699)2.77725263
28Peritonitis (HP:0002586)2.76773369
29Distal lower limb amyotrophy (HP:0008944)2.76710030
30Hypoplasia of the iris (HP:0007676)2.73272563
31Neck muscle weakness (HP:0000467)2.73221382
32Rhabdomyolysis (HP:0003201)2.68295876
33Abnormality of the phalanges of the 2nd finger (HP:0009541)2.66720386
34Ventricular tachycardia (HP:0004756)2.58228218
35Hypoplastic ischia (HP:0003175)2.58222851
36Neonatal short-limb short stature (HP:0008921)2.57359207
37Abnormality of the 2nd finger (HP:0004100)2.55313698
38Exercise-induced myalgia (HP:0003738)2.55173755
39Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.50626715
40Centrally nucleated skeletal muscle fibers (HP:0003687)2.48923985
41Mildly elevated creatine phosphokinase (HP:0008180)2.47322126
42Calf muscle hypertrophy (HP:0008981)2.46596447
43Myoglobinuria (HP:0002913)2.46279015
44Abnormality of the calf musculature (HP:0001430)2.46184862
45Back pain (HP:0003418)2.41793280
46Hyporeflexia of lower limbs (HP:0002600)2.40414910
47Aortic dissection (HP:0002647)2.39038008
48Round ear (HP:0100830)2.38656231
49Difficulty running (HP:0009046)2.35909466
50Lymphangioma (HP:0100764)2.35705673
51Nausea (HP:0002018)2.34794361
52Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.32602178
53Follicular hyperkeratosis (HP:0007502)2.32147342
54Wormian bones (HP:0002645)2.31840975
55Abnormality of the fetal cardiovascular system (HP:0010948)2.31212767
56Abnormal umbilical cord blood vessels (HP:0011403)2.31212767
57Single umbilical artery (HP:0001195)2.31212767
58Increased variability in muscle fiber diameter (HP:0003557)2.29682239
59Ankle contracture (HP:0006466)2.27217260
60Advanced eruption of teeth (HP:0006288)2.27072351
61Double outlet right ventricle (HP:0001719)2.27006669
62Congenital malformation of the right heart (HP:0011723)2.27006669
63Hip contracture (HP:0003273)2.26956752
64Natal tooth (HP:0000695)2.24329325
65Deformed tarsal bones (HP:0008119)2.23998677
66Woolly hair (HP:0002224)2.23650647
67Hemorrhage of the eye (HP:0011885)2.23568603
68Fragile skin (HP:0001030)2.23111602
69Muscle hypertrophy of the lower extremities (HP:0008968)2.21804024
70Bulbar palsy (HP:0001283)2.20733654
71Hypoalphalipoproteinemia (HP:0003233)2.20646668
72Insulin resistance (HP:0000855)2.20635714
73Abnormality of the ischium (HP:0003174)2.19833032
74Knee flexion contracture (HP:0006380)2.19546577
75Bicornuate uterus (HP:0000813)2.18927735
76Metaphyseal cupping (HP:0003021)2.17930091
77Abnormality of skeletal muscle fiber size (HP:0012084)2.17684421
78Myopathic facies (HP:0002058)2.16452839
79Reduced subcutaneous adipose tissue (HP:0003758)2.14004733
80Calcaneovalgus deformity (HP:0001848)2.13025382
81Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.12417143
82Ulnar deviation of the wrist (HP:0003049)2.12149406
83Tarsal synostosis (HP:0008368)2.10937590
84Abnormality of the proximal phalanges of the hand (HP:0009834)2.10785877
85Abnormality of the aortic arch (HP:0012303)2.10459645
86Gingival bleeding (HP:0000225)2.09779437
87Elbow flexion contracture (HP:0002987)2.09563219
88Choanal stenosis (HP:0000452)2.09497335
89Delayed epiphyseal ossification (HP:0002663)2.07661912
90Short hallux (HP:0010109)2.06101870
91Soft skin (HP:0000977)2.05700093
92Broad metatarsal (HP:0001783)2.05424658
93Epistaxis (HP:0000421)2.05263475
94Pulmonary artery stenosis (HP:0004415)2.04589987
95Aortic aneurysm (HP:0004942)2.04564028
96Bell-shaped thorax (HP:0001591)2.04388796
97Cupped ribs (HP:0000887)2.03685808
98Transposition of the great arteries (HP:0001669)2.03535201
99Abnormal connection of the cardiac segments (HP:0011545)2.03535201
100Abnormal ventriculo-arterial connection (HP:0011563)2.03535201
101Muscle fiber inclusion bodies (HP:0100299)2.03422423
102Vertebral compression fractures (HP:0002953)2.03021577
103Limited hip movement (HP:0008800)2.01830072
104Hypotrichosis (HP:0001006)2.01381703
105Abnormal tarsal ossification (HP:0008369)2.01181498
106Bladder diverticulum (HP:0000015)2.01154434
107Radial bowing (HP:0002986)2.01087111
108Flat acetabular roof (HP:0003180)1.98861593
109Abnormality of the middle phalanges of the toes (HP:0010183)1.98352644
110Xanthomatosis (HP:0000991)1.97127184
111Growth hormone excess (HP:0000845)1.96897497
112Dilated cardiomyopathy (HP:0001644)1.96711807
113Distal lower limb muscle weakness (HP:0009053)1.96440475
114Blue sclerae (HP:0000592)1.96227749
115Asymmetric septal hypertrophy (HP:0001670)1.96149611
116Absent phalangeal crease (HP:0006109)1.96148234
117Hypercortisolism (HP:0001578)1.95758696
118Distal arthrogryposis (HP:0005684)1.95370550
119Abnormality of proline metabolism (HP:0010907)1.94028969
120Hydroxyprolinuria (HP:0003080)1.94028969
121EMG: myopathic abnormalities (HP:0003458)1.90398028
122Abnormality of the common coagulation pathway (HP:0010990)1.90307924
123Abnormality of carpal bone ossification (HP:0006257)1.89567286
124Lipoatrophy (HP:0100578)1.88458907
125Rimmed vacuoles (HP:0003805)1.87431298
126Abnormal ossification of hand bones (HP:0005921)1.85988719
127Milia (HP:0001056)1.85951411
128Fibular aplasia (HP:0002990)1.85931989
129Insulin-resistant diabetes mellitus (HP:0000831)1.85414651
130Synostosis of carpal bones (HP:0005048)1.85344294
131Broad toe (HP:0001837)1.84910297
132Mitral stenosis (HP:0001718)1.84615106
133Patent foramen ovale (HP:0001655)1.84418588
134Femoral bowing (HP:0002980)1.84160889
135Flat capital femoral epiphysis (HP:0003370)1.84041570
136Coxa vara (HP:0002812)1.83959890
137Muscle stiffness (HP:0003552)1.83682568
138Venous abnormality (HP:0002624)1.83472995
139Synostosis involving bones of the lower limbs (HP:0009138)1.82686701
140Synostosis involving bones of the feet (HP:0009140)1.82686701
141Mitral valve prolapse (HP:0001634)1.82642397
142Slender build (HP:0001533)1.82399957
143Nemaline bodies (HP:0003798)1.81618755
144Cervical subluxation (HP:0003308)1.81220022
145Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.80614052
146Lower limb amyotrophy (HP:0007210)1.77856713
147Myocardial infarction (HP:0001658)1.76514230
148Proximal tubulopathy (HP:0000114)1.72304299
149Areflexia of lower limbs (HP:0002522)1.71553674
150Dysmetric saccades (HP:0000641)1.70312571
151Axonal loss (HP:0003447)1.69199946
152Ileus (HP:0002595)1.69043088
153Scapular winging (HP:0003691)1.68538756
154Subcapsular cataract (HP:0000523)1.68512869
155Asymmetry of the thorax (HP:0001555)1.68113823
156Frequent falls (HP:0002359)1.67530957
157Subaortic stenosis (HP:0001682)1.66240861
158Abnormality of the left ventricular outflow tract (HP:0011103)1.66240861
159Generalized muscle weakness (HP:0003324)1.65019523

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.53983959
2TTN3.34171367
3MAPKAPK33.13426226
4TRIB33.04314596
5EPHB22.99363685
6PKN22.64733653
7DDR22.64199051
8LATS12.33164542
9MAP3K32.18684334
10STK242.13186120
11RIPK12.04376040
12PDGFRA1.95666056
13PTK61.80120498
14PIM21.77997719
15DMPK1.76330770
16ARAF1.73917659
17TRPM71.70142687
18MAP3K141.69178850
19FLT31.67559919
20LATS21.67260464
21PTK21.63634916
22STK38L1.63114139
23MYLK1.60705058
24LRRK21.57447380
25FER1.45146512
26MAPK151.44955964
27STK381.42927938
28NME21.41436507
29EPHA21.38230941
30CHUK1.35974437
31MAPK121.35673832
32STK391.29965296
33LIMK11.24194750
34IKBKB1.23871631
35PIK3CA1.21965785
36PAK21.21949799
37LMTK21.19558319
38AKT31.19498295
39MAP2K31.18841253
40STK31.18405163
41MST1R1.18112154
42PTK2B1.16956034
43MAP3K101.14806823
44MAP3K131.13705650
45NEK91.13301640
46ILK1.11081505
47SIK11.09593294
48TYK21.09497653
49RPS6KA41.07371442
50PRKAA21.05233795
51BMX1.03629593
52ABL21.02644979
53RPS6KL10.99534943
54RPS6KC10.99534943
55OXSR10.98800497
56TESK10.96564795
57PDPK10.95060561
58CDC42BPA0.92052237
59RPS6KA60.91744675
60FGFR10.90988518
61MAPKAPK20.89577264
62ROCK10.89502468
63PHKG20.88610889
64PHKG10.88610889
65PDGFRB0.88560816
66NME10.88391316
67JAK30.87854526
68TGFBR10.85145960
69RPS6KA20.84923402
70ICK0.83657367
71FGFR30.82152148
72AKT20.77128102
73JAK10.76846365
74TBK10.76569400
75PDK20.76011040
76MAPK110.75428135
77MAP2K20.74511179
78MAP3K120.73688052
79MST40.73324355
80CAMK10.72329181
81EPHA30.70712589
82PAK40.69298003
83GRK50.68639862
84RPS6KA10.66506787
85BCR0.65696546
86PINK10.65205333
87ERBB30.64980281
88RET0.64759399
89MAP3K60.64513224
90DAPK30.64400990
91PKN10.63005026
92CAMK2G0.61830621
93PAK30.61424222
94NEK10.60574020
95EEF2K0.58798856
96PRKD10.58525999
97MET0.58122459
98ROCK20.57593673
99KDR0.57593163
100FGFR40.56294599
101PRKG20.55578688
102NUAK10.55453722
103MOS0.54969389
104MAP3K10.54763430
105GSK3A0.54168386
106MAPK40.54010230
107PRKAA10.51212027
108MAP2K10.50309853
109MAPK70.49243397
110STK100.48637384
111PBK0.48167789
112WNK40.47189544
113EPHB10.46087186
114SMG10.45977768
115ERN10.44699025
116PAK10.44585695
117PDK10.44350488
118RPS6KB20.43919723
119MAP3K70.43233254
120MAPKAPK50.43084394
121ZAP700.42007447
122IRAK30.41629060
123DYRK1B0.41169515
124PIK3CG0.39625995
125TGFBR20.38815164
126EIF2AK10.38356806
127PRKG10.38208550
128CDK40.37272672
129SCYL20.37217697
130PLK40.36719273
131DAPK20.36701490
132PIM10.36164435
133AKT10.35654499
134SRC0.34454900
135EGFR0.34395077
136TIE10.33427633
137MTOR0.32582002
138PRKACG0.32336707
139PRPF4B0.31464108
140CAMK40.31269702
141CSF1R0.30499978
142CSK0.29343494
143RIPK40.29168143
144NEK20.27299979

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.04778143
2PPAR signaling pathway_Homo sapiens_hsa033203.66366646
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.85716175
4Focal adhesion_Homo sapiens_hsa045102.84344397
5Dilated cardiomyopathy_Homo sapiens_hsa054142.80511292
6Small cell lung cancer_Homo sapiens_hsa052222.69273069
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.65520177
8Fatty acid elongation_Homo sapiens_hsa000622.29886956
9Amoebiasis_Homo sapiens_hsa051462.20849475
10Fatty acid biosynthesis_Homo sapiens_hsa000612.19672520
11Toxoplasmosis_Homo sapiens_hsa051452.17050346
12Cardiac muscle contraction_Homo sapiens_hsa042602.16773099
13Phenylalanine metabolism_Homo sapiens_hsa003602.13760466
14* Hippo signaling pathway_Homo sapiens_hsa043902.11319780
15Glycerolipid metabolism_Homo sapiens_hsa005612.10736706
16Fat digestion and absorption_Homo sapiens_hsa049752.09894465
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.04508354
18Fatty acid degradation_Homo sapiens_hsa000711.92861858
19* Basal cell carcinoma_Homo sapiens_hsa052171.84945003
20* Proteoglycans in cancer_Homo sapiens_hsa052051.84890432
21TGF-beta signaling pathway_Homo sapiens_hsa043501.80118359
22Sulfur relay system_Homo sapiens_hsa041221.78838502
23Protein digestion and absorption_Homo sapiens_hsa049741.73652654
24Adherens junction_Homo sapiens_hsa045201.72765679
25Pyruvate metabolism_Homo sapiens_hsa006201.71175781
26Tyrosine metabolism_Homo sapiens_hsa003501.71118450
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.63845892
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.52149743
29Tight junction_Homo sapiens_hsa045301.49434995
30Fatty acid metabolism_Homo sapiens_hsa012121.43008543
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.42620706
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.41797804
33MicroRNAs in cancer_Homo sapiens_hsa052061.37764360
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.37561597
35Renin-angiotensin system_Homo sapiens_hsa046141.34252637
36HIF-1 signaling pathway_Homo sapiens_hsa040661.30802798
37PI3K-Akt signaling pathway_Homo sapiens_hsa041511.27714759
38* Pathways in cancer_Homo sapiens_hsa052001.24726900
39* Hedgehog signaling pathway_Homo sapiens_hsa043401.23383635
40Vitamin digestion and absorption_Homo sapiens_hsa049771.22682239
41Arginine and proline metabolism_Homo sapiens_hsa003301.21061476
42Insulin resistance_Homo sapiens_hsa049311.20884930
43Pentose phosphate pathway_Homo sapiens_hsa000301.20881234
44Viral myocarditis_Homo sapiens_hsa054161.17898556
45beta-Alanine metabolism_Homo sapiens_hsa004101.15405313
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13533775
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.13305877
48Apoptosis_Homo sapiens_hsa042101.12357847
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11842708
50Central carbon metabolism in cancer_Homo sapiens_hsa052301.11615796
51Regulation of actin cytoskeleton_Homo sapiens_hsa048101.11376561
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.10387660
53TNF signaling pathway_Homo sapiens_hsa046681.07431457
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07042886
55Bladder cancer_Homo sapiens_hsa052191.03633919
56Arginine biosynthesis_Homo sapiens_hsa002201.03270130
57Carbon metabolism_Homo sapiens_hsa012001.00512342
58Propanoate metabolism_Homo sapiens_hsa006401.00272973
59Glutathione metabolism_Homo sapiens_hsa004800.99156082
60Osteoclast differentiation_Homo sapiens_hsa043800.94683014
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.93862853
62* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93024516
63* HTLV-I infection_Homo sapiens_hsa051660.92692003
64Galactose metabolism_Homo sapiens_hsa000520.92571511
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90417490
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88069997
67Chronic myeloid leukemia_Homo sapiens_hsa052200.87805568
68Axon guidance_Homo sapiens_hsa043600.87756501
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87698051
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86943060
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.85983056
72* Melanogenesis_Homo sapiens_hsa049160.85849632
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85547805
74Sulfur metabolism_Homo sapiens_hsa009200.85184656
75Malaria_Homo sapiens_hsa051440.85137738
76Starch and sucrose metabolism_Homo sapiens_hsa005000.84509110
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84070336
78Antigen processing and presentation_Homo sapiens_hsa046120.83250981
79Leishmaniasis_Homo sapiens_hsa051400.82112677
80VEGF signaling pathway_Homo sapiens_hsa043700.81453144
81Gap junction_Homo sapiens_hsa045400.81258624
82Thyroid cancer_Homo sapiens_hsa052160.80192711
83Rap1 signaling pathway_Homo sapiens_hsa040150.80152236
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.79487287
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.79157474
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.78895641
87Platelet activation_Homo sapiens_hsa046110.78441914
88Histidine metabolism_Homo sapiens_hsa003400.77382733
89Tryptophan metabolism_Homo sapiens_hsa003800.76381824
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75841521
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75221471
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.72821480
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.72637654
94MAPK signaling pathway_Homo sapiens_hsa040100.72002250
95Renal cell carcinoma_Homo sapiens_hsa052110.71928557
96Oxytocin signaling pathway_Homo sapiens_hsa049210.71187218
97Insulin signaling pathway_Homo sapiens_hsa049100.70183868
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.70102605
99GnRH signaling pathway_Homo sapiens_hsa049120.69903467
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.66940173
101Acute myeloid leukemia_Homo sapiens_hsa052210.65841978
102Other glycan degradation_Homo sapiens_hsa005110.65557270
103* Wnt signaling pathway_Homo sapiens_hsa043100.65488497
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64893177
105Prostate cancer_Homo sapiens_hsa052150.64418489
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64090760
107Folate biosynthesis_Homo sapiens_hsa007900.63727188
108Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63255296
109Complement and coagulation cascades_Homo sapiens_hsa046100.62868325
110Bile secretion_Homo sapiens_hsa049760.61790760
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61501779
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.61460092
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60956242
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60730808
115Estrogen signaling pathway_Homo sapiens_hsa049150.60699357
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60531044
117p53 signaling pathway_Homo sapiens_hsa041150.58118488
118Prion diseases_Homo sapiens_hsa050200.58025040
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57739581
120Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57421678
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57172921
122Shigellosis_Homo sapiens_hsa051310.56851989
123Melanoma_Homo sapiens_hsa052180.56259574
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54744180
125Nitrogen metabolism_Homo sapiens_hsa009100.53264223
126Glucagon signaling pathway_Homo sapiens_hsa049220.53058819
127Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50924094
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.50390586
129Huntingtons disease_Homo sapiens_hsa050160.50154551
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50138217
131Viral carcinogenesis_Homo sapiens_hsa052030.49983240
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49310131
133Notch signaling pathway_Homo sapiens_hsa043300.48031188
134Arachidonic acid metabolism_Homo sapiens_hsa005900.47345855
135Parkinsons disease_Homo sapiens_hsa050120.47314145
136Pancreatic cancer_Homo sapiens_hsa052120.46981224
137Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46881332
138Prolactin signaling pathway_Homo sapiens_hsa049170.46648971
139Ovarian steroidogenesis_Homo sapiens_hsa049130.46628749
140Legionellosis_Homo sapiens_hsa051340.45410356
141AMPK signaling pathway_Homo sapiens_hsa041520.45140043
142Salmonella infection_Homo sapiens_hsa051320.44836010
143Retinol metabolism_Homo sapiens_hsa008300.44039532
144Chemical carcinogenesis_Homo sapiens_hsa052040.43815552
145Biosynthesis of amino acids_Homo sapiens_hsa012300.43729000
146Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41818985
147Fructose and mannose metabolism_Homo sapiens_hsa000510.41733000
148Endometrial cancer_Homo sapiens_hsa052130.41541623
149Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40520899
150cAMP signaling pathway_Homo sapiens_hsa040240.40284106
151Pancreatic secretion_Homo sapiens_hsa049720.38042002
152Renin secretion_Homo sapiens_hsa049240.37928626
153ABC transporters_Homo sapiens_hsa020100.37707400
154mTOR signaling pathway_Homo sapiens_hsa041500.37469726
155Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37439425
156Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35696829
157Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34734497
158Peroxisome_Homo sapiens_hsa041460.33880710

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