WIPF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.78377215
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.67553820
3locomotory exploration behavior (GO:0035641)5.57994776
4vocalization behavior (GO:0071625)5.38015095
5ionotropic glutamate receptor signaling pathway (GO:0035235)5.30388919
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.28700902
7behavioral response to nicotine (GO:0035095)5.23596756
8regulation of glutamate receptor signaling pathway (GO:1900449)5.10779870
9synaptic vesicle maturation (GO:0016188)5.08028678
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.91340141
11regulation of neuronal synaptic plasticity (GO:0048168)4.77089969
12synaptic vesicle exocytosis (GO:0016079)4.69953046
13regulation of long-term neuronal synaptic plasticity (GO:0048169)4.68374415
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.66574716
15protein localization to synapse (GO:0035418)4.65898369
16glutamate receptor signaling pathway (GO:0007215)4.63333765
17glutamate secretion (GO:0014047)4.55771697
18regulation of synapse structural plasticity (GO:0051823)4.52729864
19exploration behavior (GO:0035640)4.52551468
20synaptic transmission, glutamatergic (GO:0035249)4.47853021
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.44844294
22regulation of synaptic vesicle exocytosis (GO:2000300)4.21227164
23presynaptic membrane assembly (GO:0097105)4.19755882
24regulation of excitatory postsynaptic membrane potential (GO:0060079)4.19552253
25establishment of protein localization to mitochondrial membrane (GO:0090151)4.17834721
26regulation of dendritic spine morphogenesis (GO:0061001)4.17730017
27neurotransmitter-gated ion channel clustering (GO:0072578)4.16396969
28neuron-neuron synaptic transmission (GO:0007270)4.13186628
29neuronal action potential propagation (GO:0019227)4.12998812
30long-term memory (GO:0007616)4.09405625
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.04004471
32regulation of synaptic plasticity (GO:0048167)4.01976574
33positive regulation of synapse maturation (GO:0090129)4.00854853
34water-soluble vitamin biosynthetic process (GO:0042364)3.99386302
35dendritic spine morphogenesis (GO:0060997)3.99153469
36regulation of synaptic vesicle transport (GO:1902803)3.98185555
37protein complex biogenesis (GO:0070271)3.96100387
38regulation of postsynaptic membrane potential (GO:0060078)3.89335938
39presynaptic membrane organization (GO:0097090)3.88551773
40neuron cell-cell adhesion (GO:0007158)3.85369324
41positive regulation of membrane potential (GO:0045838)3.81703885
42behavioral defense response (GO:0002209)3.80491137
43behavioral fear response (GO:0001662)3.80491137
44dendritic spine organization (GO:0097061)3.74802435
45cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.74164886
46chemosensory behavior (GO:0007635)3.72853387
47pyrimidine nucleobase catabolic process (GO:0006208)3.70486231
48cellular potassium ion homeostasis (GO:0030007)3.66020026
49long-term synaptic potentiation (GO:0060291)3.64112925
50mitochondrial respiratory chain complex I assembly (GO:0032981)3.62545470
51NADH dehydrogenase complex assembly (GO:0010257)3.62545470
52mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.62545470
53somite development (GO:0061053)3.61818712
54neurotransmitter secretion (GO:0007269)3.61568309
55G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.59555733
56positive regulation of dendritic spine morphogenesis (GO:0061003)3.57318634
57mitochondrial respiratory chain complex assembly (GO:0033108)3.53157682
58innervation (GO:0060384)3.51692305
59cell communication by electrical coupling (GO:0010644)3.49902324
60neuron recognition (GO:0008038)3.44980335
61fear response (GO:0042596)3.42716843
62regulation of dendritic spine development (GO:0060998)3.40381029
63regulation of female receptivity (GO:0045924)3.37840861
64positive regulation of dendritic spine development (GO:0060999)3.37640251
65positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.36973922
66sodium ion export (GO:0071436)3.36849706
67layer formation in cerebral cortex (GO:0021819)3.35578802
68response to histamine (GO:0034776)3.35493549
69neuromuscular process controlling balance (GO:0050885)3.34495436
70transmission of nerve impulse (GO:0019226)3.33915600
71negative regulation of transcription regulatory region DNA binding (GO:2000678)3.32344761
72negative regulation of synaptic transmission, GABAergic (GO:0032229)3.29764283
73synaptic vesicle endocytosis (GO:0048488)3.29156986
74long term synaptic depression (GO:0060292)3.28132627
75membrane depolarization (GO:0051899)3.27370326
76positive regulation of neurotransmitter secretion (GO:0001956)3.26436624
77gamma-aminobutyric acid signaling pathway (GO:0007214)3.23837718
78regulation of synaptic transmission, glutamatergic (GO:0051966)3.21789018
79postsynaptic membrane organization (GO:0001941)3.20514784
80otic vesicle formation (GO:0030916)3.19676169
81learning (GO:0007612)3.19576138
82membrane depolarization during action potential (GO:0086010)3.19534561
83positive regulation of neurotransmitter transport (GO:0051590)3.17900498
84regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.17079720
85protein polyglutamylation (GO:0018095)3.16478495
86regulation of vesicle fusion (GO:0031338)3.13886226
87mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.12559423
88axonal fasciculation (GO:0007413)3.11273358
89G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.09613626
90nucleobase catabolic process (GO:0046113)3.08567486
91proline transport (GO:0015824)3.07651087
92mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.07581473
93positive regulation of synaptic transmission, GABAergic (GO:0032230)3.07010769
94negative regulation of response to food (GO:0032096)3.05421049
95negative regulation of appetite (GO:0032099)3.05421049
96activation of protein kinase A activity (GO:0034199)3.05119359
97regulation of glutamate secretion (GO:0014048)3.04869933
98regulation of synapse maturation (GO:0090128)3.04502711
99female mating behavior (GO:0060180)3.04482420
100gamma-aminobutyric acid transport (GO:0015812)3.03427461
101detection of calcium ion (GO:0005513)3.03224403
102regulation of synaptic transmission (GO:0050804)3.01836871
103cellular sodium ion homeostasis (GO:0006883)3.01241751
104regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.00370144
105regulation of neurotransmitter secretion (GO:0046928)2.99079273
106neuronal ion channel clustering (GO:0045161)2.98206074
107behavioral response to cocaine (GO:0048148)2.98090912
108regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.97529975
109serotonin metabolic process (GO:0042428)2.95797260
110negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.95682487
111positive regulation of synaptic transmission (GO:0050806)2.95498079
112signal complex assembly (GO:0007172)2.93845475
113vesicle transport along microtubule (GO:0047496)2.93783998
114regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.92932932
115positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.91534195
116neurotransmitter transport (GO:0006836)2.91341285
117positive regulation of fibroblast migration (GO:0010763)2.90541794
118negative regulation of amino acid transport (GO:0051956)2.88359229
119synaptic transmission, dopaminergic (GO:0001963)2.87360241
120response to amphetamine (GO:0001975)2.86928257
121synaptic transmission (GO:0007268)2.85943810
122ATP synthesis coupled proton transport (GO:0015986)2.84148127
123energy coupled proton transport, down electrochemical gradient (GO:0015985)2.84148127
124neuromuscular process (GO:0050905)2.83688676
125neuronal action potential (GO:0019228)2.83154057
126response to pheromone (GO:0019236)2.82912073
127cornea development in camera-type eye (GO:0061303)2.80476478
128primary amino compound metabolic process (GO:1901160)2.77802253
129regulation of cilium movement (GO:0003352)2.76492975
130retinal cone cell development (GO:0046549)2.74311426
131nonmotile primary cilium assembly (GO:0035058)2.73648723
132protein-cofactor linkage (GO:0018065)2.72424959
133cytochrome complex assembly (GO:0017004)2.71816602
134negative regulation of cytosolic calcium ion concentration (GO:0051481)2.70762497
135retinal ganglion cell axon guidance (GO:0031290)2.70477827
136limb bud formation (GO:0060174)2.69491545
137kidney morphogenesis (GO:0060993)2.69341270
138protein neddylation (GO:0045116)2.68781333
139cell proliferation in forebrain (GO:0021846)2.68686887
140C4-dicarboxylate transport (GO:0015740)2.67330475
141synaptic transmission, cholinergic (GO:0007271)2.66485208
142platelet dense granule organization (GO:0060155)2.64930210
143regulation of action potential (GO:0098900)2.58678815
144positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.58078577
145regulation of neurotransmitter uptake (GO:0051580)2.58070772
146adaptation of signaling pathway (GO:0023058)2.57711849
147chaperone-mediated protein transport (GO:0072321)2.55611812
148photoreceptor cell development (GO:0042461)2.55396745
149synapse assembly (GO:0007416)2.55351802
150reflex (GO:0060004)2.53195570
151regulation of membrane repolarization (GO:0060306)2.53023133
152L-fucose catabolic process (GO:0042355)2.52088454
153fucose catabolic process (GO:0019317)2.52088454
154L-fucose metabolic process (GO:0042354)2.52088454
155respiratory chain complex IV assembly (GO:0008535)2.51801775
156spinal cord motor neuron differentiation (GO:0021522)2.50168454
157DNA deamination (GO:0045006)2.49695984
158hindbrain development (GO:0030902)2.49159495
159positive regulation of male gonad development (GO:2000020)2.48749405
160auditory behavior (GO:0031223)2.48149399
161spinal cord development (GO:0021510)2.47838448
162negative regulation of membrane potential (GO:0045837)2.47811032
163action potential (GO:0001508)2.47077265
164intracellular protein transmembrane import (GO:0044743)2.45837944
165electron transport chain (GO:0022900)2.45529598
166protein localization to cilium (GO:0061512)2.44072563
167respiratory electron transport chain (GO:0022904)2.43733007
168regulation of rhodopsin mediated signaling pathway (GO:0022400)2.43072768
169regulation of collateral sprouting (GO:0048670)2.41570291
170epithelial cilium movement (GO:0003351)2.39827555
171detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.38266146
172short-term memory (GO:0007614)2.36557819
173regulation of male gonad development (GO:2000018)2.36056550
174sulfation (GO:0051923)2.35927208
175neuromuscular synaptic transmission (GO:0007274)2.34368345
176positive regulation of potassium ion transmembrane transport (GO:1901381)2.31767574
177mechanosensory behavior (GO:0007638)2.31296958
178epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.30904651
179startle response (GO:0001964)2.28969590
180eye photoreceptor cell development (GO:0042462)2.28930491
181axoneme assembly (GO:0035082)2.28546491

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.53239169
2GBX2_23144817_ChIP-Seq_PC3_Human3.41866244
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.15075438
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14147299
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12526283
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.86022822
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78362677
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78362677
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.73419593
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69877606
11REST_21632747_ChIP-Seq_MESCs_Mouse2.60123975
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57362797
13DROSHA_22980978_ChIP-Seq_HELA_Human2.53165096
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51976705
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49020206
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48700385
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.40216660
18VDR_22108803_ChIP-Seq_LS180_Human2.37516467
19IGF1R_20145208_ChIP-Seq_DFB_Human2.33178155
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.26700058
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.23875338
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.23593804
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23282153
24* EZH2_27294783_Chip-Seq_ESCs_Mouse2.20279834
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.18785719
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.15376313
27REST_18959480_ChIP-ChIP_MESCs_Mouse2.12300783
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.04942372
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90174351
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77207589
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74944882
32RNF2_27304074_Chip-Seq_NSC_Mouse1.71863860
33EWS_26573619_Chip-Seq_HEK293_Human1.71499112
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69253241
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.68741623
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67630109
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67426696
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66477213
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66308325
40SMAD4_21799915_ChIP-Seq_A2780_Human1.63144380
41* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61977313
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.59805215
43AR_21572438_ChIP-Seq_LNCaP_Human1.56374449
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52320991
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52317467
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.50176354
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44245073
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42622630
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42004975
50POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42004975
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41762069
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39493874
53ER_23166858_ChIP-Seq_MCF-7_Human1.37641200
54ZNF274_21170338_ChIP-Seq_K562_Hela1.37285270
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33679383
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33061742
57RING1B_27294783_Chip-Seq_ESCs_Mouse1.32273913
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31751481
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30817833
60TAF15_26573619_Chip-Seq_HEK293_Human1.30092855
61* CBP_20019798_ChIP-Seq_JUKART_Human1.28515125
62* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28515125
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26726528
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.26289270
65* P300_19829295_ChIP-Seq_ESCs_Human1.25843556
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25568111
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25438100
68TP53_22573176_ChIP-Seq_HFKS_Human1.24833614
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.24597616
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24035988
71RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23552929
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22780717
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22514841
74MYC_18940864_ChIP-ChIP_HL60_Human1.21149558
75AR_25329375_ChIP-Seq_VCAP_Human1.20899632
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20775462
77WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20452050
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.19687787
79AR_19668381_ChIP-Seq_PC3_Human1.19042860
80GABP_17652178_ChIP-ChIP_JURKAT_Human1.17946673
81DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17900898
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16896352
83ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16684827
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15813508
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.15606553
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14562082
87* STAT3_23295773_ChIP-Seq_U87_Human1.14491015
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.14356761
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12564366
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12311650
91ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12167010
92RING1B_27294783_Chip-Seq_NPCs_Mouse1.12122722
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11903916
94EST1_17652178_ChIP-ChIP_JURKAT_Human1.10970272
95KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.10875180
96EZH2_27294783_Chip-Seq_NPCs_Mouse1.10206081
97TP53_16413492_ChIP-PET_HCT116_Human1.10144463
98SMAD3_21741376_ChIP-Seq_HESCs_Human1.08629683
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.07994045
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07948047
101TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07333430
102P53_22387025_ChIP-Seq_ESCs_Mouse1.07031480
103* KDM2B_26808549_Chip-Seq_K562_Human1.06886894
104* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06759984
105NANOG_19829295_ChIP-Seq_ESCs_Human1.06698050
106SOX2_19829295_ChIP-Seq_ESCs_Human1.06698050
107IRF1_19129219_ChIP-ChIP_H3396_Human1.06635434
108EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06634728
109* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06499864
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04966847
111CBX2_27304074_Chip-Seq_ESCs_Mouse1.04758421
112NCOR_22424771_ChIP-Seq_293T_Human1.04753448
113ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04302140
114FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03468698
115CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03313913
116PRDM14_20953172_ChIP-Seq_ESCs_Human1.03159741
117GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02917559
118* TCF4_23295773_ChIP-Seq_U87_Human1.02431926
119KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02184352
120AHR_22903824_ChIP-Seq_MCF-7_Human1.00896162
121TCF4_22108803_ChIP-Seq_LS180_Human1.00603652
122PIAS1_25552417_ChIP-Seq_VCAP_Human0.99617584
123YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99562806
124NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98912433
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98784896
126P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98245697
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98099593
128RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97819859
129SMAD4_21741376_ChIP-Seq_HESCs_Human0.96717608
130MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96134643
131BCAT_22108803_ChIP-Seq_LS180_Human0.96003243
132CTCF_27219007_Chip-Seq_Bcells_Human0.95013693
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92516638
134THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92205832
135EP300_21415370_ChIP-Seq_HL-1_Mouse0.91760391
136SMAD_19615063_ChIP-ChIP_OVARY_Human0.91194705
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91140102
138RUNX2_22187159_ChIP-Seq_PCA_Human0.88749864
139BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87791225
140TP53_18474530_ChIP-ChIP_U2OS_Human0.87676580
141SMAD3_21741376_ChIP-Seq_ESCs_Human0.87536578
142FUS_26573619_Chip-Seq_HEK293_Human0.86549757
143* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86510510
144ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85844265
145ESR1_20079471_ChIP-ChIP_T-47D_Human0.85677932

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.83877189
2MP0003880_abnormal_central_pattern5.53824588
3MP0003635_abnormal_synaptic_transmissio4.26368871
4MP0006292_abnormal_olfactory_placode3.72395902
5MP0004270_analgesia3.69298660
6MP0002063_abnormal_learning/memory/cond3.54606638
7MP0009745_abnormal_behavioral_response3.50622828
8MP0002822_catalepsy3.12078491
9MP0002064_seizures3.07118340
10MP0001968_abnormal_touch/_nociception2.91966501
11MP0002572_abnormal_emotion/affect_behav2.82059625
12MP0002272_abnormal_nervous_system2.57694784
13MP0002736_abnormal_nociception_after2.47072264
14MP0002735_abnormal_chemical_nociception2.41798543
15MP0001486_abnormal_startle_reflex2.35477180
16MP0009046_muscle_twitch2.33872474
17MP0001440_abnormal_grooming_behavior2.28535929
18MP0001501_abnormal_sleep_pattern2.28272408
19MP0002734_abnormal_mechanical_nocicepti2.13944221
20MP0009780_abnormal_chondrocyte_physiolo2.04497436
21MP0002102_abnormal_ear_morphology2.03684544
22MP0006072_abnormal_retinal_apoptosis1.86641492
23MP0005423_abnormal_somatic_nervous1.82822122
24MP0003879_abnormal_hair_cell1.80587305
25MP0003329_amyloid_beta_deposits1.77215938
26MP0002733_abnormal_thermal_nociception1.77052720
27MP0004858_abnormal_nervous_system1.76911711
28MP0001970_abnormal_pain_threshold1.73883382
29MP0003011_delayed_dark_adaptation1.73714257
30MP0002909_abnormal_adrenal_gland1.72417532
31MP0002067_abnormal_sensory_capabilities1.70862075
32MP0000631_abnormal_neuroendocrine_gland1.68786658
33MP0002837_dystrophic_cardiac_calcinosis1.63734302
34MP0004811_abnormal_neuron_physiology1.63568647
35MP0008789_abnormal_olfactory_epithelium1.63131507
36MP0008569_lethality_at_weaning1.61489417
37MP0000751_myopathy1.58087426
38MP0004133_heterotaxia1.58086606
39MP0000778_abnormal_nervous_system1.55549556
40MP0002184_abnormal_innervation1.55406288
41MP0002638_abnormal_pupillary_reflex1.55365582
42MP0003787_abnormal_imprinting1.53068029
43MP0002557_abnormal_social/conspecific_i1.49348155
44MP0003121_genomic_imprinting1.49086054
45MP0004924_abnormal_behavior1.43885001
46MP0005386_behavior/neurological_phenoty1.43885001
47MP0002938_white_spotting1.43686785
48MP0004885_abnormal_endolymph1.38896680
49MP0005646_abnormal_pituitary_gland1.37846392
50MP0005253_abnormal_eye_physiology1.36142037
51MP0002160_abnormal_reproductive_system1.35961628
52MP0006276_abnormal_autonomic_nervous1.34646144
53MP0000049_abnormal_middle_ear1.31023513
54MP0000955_abnormal_spinal_cord1.30282488
55MP0002066_abnormal_motor_capabilities/c1.29536793
56MP0002882_abnormal_neuron_morphology1.26688302
57MP0005394_taste/olfaction_phenotype1.26429492
58MP0005499_abnormal_olfactory_system1.26429492
59MP0003633_abnormal_nervous_system1.26325584
60MP0004510_myositis1.26285258
61MP0003890_abnormal_embryonic-extraembry1.23773496
62MP0002653_abnormal_ependyma_morphology1.22867587
63MP0001905_abnormal_dopamine_level1.22649307
64MP0003938_abnormal_ear_development1.22568002
65MP0001529_abnormal_vocalization1.22544119
66MP0003195_calcinosis1.20194434
67MP0003567_abnormal_fetal_cardiomyocyte1.18364979
68MP0004215_abnormal_myocardial_fiber1.17599205
69MP0003075_altered_response_to1.17472179
70MP0004484_altered_response_of1.12587466
71MP0005389_reproductive_system_phenotype1.11275040
72MP0004145_abnormal_muscle_electrophysio1.10721009
73MP0001984_abnormal_olfaction1.09652908
74MP0003119_abnormal_digestive_system1.07160618
75MP0003631_nervous_system_phenotype1.06480055
76MP0001502_abnormal_circadian_rhythm1.05972820
77MP0005409_darkened_coat_color1.03944251
78MP0001188_hyperpigmentation1.03768312
79MP0008874_decreased_physiological_sensi1.03737379
80MP0004085_abnormal_heartbeat1.03426978
81MP0000026_abnormal_inner_ear1.01273706
82MP0003136_yellow_coat_color1.01262894
83MP0000372_irregular_coat_pigmentation1.00072733
84MP0008775_abnormal_heart_ventricle0.99079534
85MP0002752_abnormal_somatic_nervous0.98877009
86MP0002751_abnormal_autonomic_nervous0.98678178
87MP0002152_abnormal_brain_morphology0.95138029
88MP0003937_abnormal_limbs/digits/tail_de0.94795866
89MP0004147_increased_porphyrin_level0.93721775
90MP0001986_abnormal_taste_sensitivity0.92764036
91MP0003646_muscle_fatigue0.92677691
92MP0008872_abnormal_physiological_respon0.91759937
93MP0005535_abnormal_body_temperature0.90978089
94MP0002069_abnormal_eating/drinking_beha0.89666890
95MP0008995_early_reproductive_senescence0.86274521
96MP0005195_abnormal_posterior_eye0.85194929
97MP0008961_abnormal_basal_metabolism0.84967705
98MP0008058_abnormal_DNA_repair0.84866360
99MP0003137_abnormal_impulse_conducting0.83187748
100MP0000566_synostosis0.83124333
101MP0001919_abnormal_reproductive_system0.81911353
102MP0002229_neurodegeneration0.81179411
103MP0000604_amyloidosis0.79115575
104MP0003123_paternal_imprinting0.77919128
105MP0002277_abnormal_respiratory_mucosa0.77868109
106MP0008877_abnormal_DNA_methylation0.77513992
107MP0005645_abnormal_hypothalamus_physiol0.77378995
108MP0005167_abnormal_blood-brain_barrier0.77300323
109MP0001485_abnormal_pinna_reflex0.77099878
110MP0000537_abnormal_urethra_morphology0.76753751
111MP0008875_abnormal_xenobiotic_pharmacok0.76373177
112MP0001177_atelectasis0.76178595
113MP0002163_abnormal_gland_morphology0.75941284
114MP0004036_abnormal_muscle_relaxation0.75519078
115MP0005379_endocrine/exocrine_gland_phen0.75341432
116MP0004142_abnormal_muscle_tone0.74343455
117MP0001963_abnormal_hearing_physiology0.73914592
118MP0002234_abnormal_pharynx_morphology0.70834920
119MP0001765_abnormal_ion_homeostasis0.69993383
120MP0003690_abnormal_glial_cell0.68371221
121MP0005620_abnormal_muscle_contractility0.68186874
122MP0003632_abnormal_nervous_system0.67995957
123MP0004742_abnormal_vestibular_system0.66722194
124MP0001664_abnormal_digestion0.64780414
125MP0004130_abnormal_muscle_cell0.64696272
126MP0010386_abnormal_urinary_bladder0.64541442
127MP0004233_abnormal_muscle_weight0.64450265
128MP0000013_abnormal_adipose_tissue0.63494089
129MP0002090_abnormal_vision0.63346613
130MP0003122_maternal_imprinting0.63291667
131MP0005551_abnormal_eye_electrophysiolog0.62430052
132MP0003634_abnormal_glial_cell0.61828788
133MP0010234_abnormal_vibrissa_follicle0.61668313
134MP0003283_abnormal_digestive_organ0.61559123
135MP0002876_abnormal_thyroid_physiology0.58638986
136MP0000920_abnormal_myelination0.58364046
137MP0006138_congestive_heart_failure0.57920764
138MP0005623_abnormal_meninges_morphology0.57040755
139MP0004043_abnormal_pH_regulation0.56789055
140MP0004084_abnormal_cardiac_muscle0.55987315
141MP0000747_muscle_weakness0.55601062
142MP0005171_absent_coat_pigmentation0.55386470

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.80641448
2Myokymia (HP:0002411)7.83865317
3Focal seizures (HP:0007359)5.99073494
4Visual hallucinations (HP:0002367)5.13050608
5Epileptic encephalopathy (HP:0200134)4.70454354
6Atonic seizures (HP:0010819)4.36727357
7Febrile seizures (HP:0002373)4.27683408
8Absence seizures (HP:0002121)4.18754527
9Progressive cerebellar ataxia (HP:0002073)4.12540440
10Dialeptic seizures (HP:0011146)4.03520809
11Generalized tonic-clonic seizures (HP:0002069)4.02294871
12Abnormality of the lower motor neuron (HP:0002366)3.89720740
13Action tremor (HP:0002345)3.89633995
14Hyperventilation (HP:0002883)3.79723562
15Amblyopia (HP:0000646)3.66103000
16Impaired vibration sensation in the lower limbs (HP:0002166)3.62183896
17True hermaphroditism (HP:0010459)3.52433788
18Dysmetria (HP:0001310)3.46202631
19Methylmalonic acidemia (HP:0002912)3.39858515
20Congenital stationary night blindness (HP:0007642)3.36800036
21Depression (HP:0000716)3.34660059
22Supranuclear gaze palsy (HP:0000605)3.34619618
23Broad-based gait (HP:0002136)3.33169530
24Pancreatic cysts (HP:0001737)3.33024817
25Gaze-evoked nystagmus (HP:0000640)3.29050328
26Anxiety (HP:0000739)3.27347836
27Nephronophthisis (HP:0000090)3.24472516
28Dysdiadochokinesis (HP:0002075)3.24318657
29Poor eye contact (HP:0000817)3.20608845
30Pancreatic fibrosis (HP:0100732)3.19714947
31Ankle clonus (HP:0011448)2.98099848
32Molar tooth sign on MRI (HP:0002419)2.97967699
33Abnormality of midbrain morphology (HP:0002418)2.97967699
34Medial flaring of the eyebrow (HP:0010747)2.96436242
35Ventricular fibrillation (HP:0001663)2.94574163
36Impaired social interactions (HP:0000735)2.94207449
37Abnormal social behavior (HP:0012433)2.94207449
38Postural instability (HP:0002172)2.89407487
39Methylmalonic aciduria (HP:0012120)2.86743070
40Cerebral inclusion bodies (HP:0100314)2.86661068
41Acute necrotizing encephalopathy (HP:0006965)2.85798339
42Urinary bladder sphincter dysfunction (HP:0002839)2.84858117
43Truncal ataxia (HP:0002078)2.82237321
44Abnormality of the labia minora (HP:0012880)2.75441510
45Gait imbalance (HP:0002141)2.73390676
46Annular pancreas (HP:0001734)2.69655866
47Progressive macrocephaly (HP:0004481)2.68653053
48Impaired smooth pursuit (HP:0007772)2.62556299
49Excessive salivation (HP:0003781)2.62499991
50Drooling (HP:0002307)2.62499991
51Hyperglycinemia (HP:0002154)2.59931118
52Urinary urgency (HP:0000012)2.58279686
53Bundle branch block (HP:0011710)2.57763308
54Sudden death (HP:0001699)2.55899058
55Mitochondrial inheritance (HP:0001427)2.55898523
56Pendular nystagmus (HP:0012043)2.55597546
57Epileptiform EEG discharges (HP:0011182)2.55237302
58Focal dystonia (HP:0004373)2.53408386
59Abnormality of the renal medulla (HP:0100957)2.52321216
60Torticollis (HP:0000473)2.51763669
61Abnormal mitochondria in muscle tissue (HP:0008316)2.50298052
62Abnormal eating behavior (HP:0100738)2.49167636
63Dysmetric saccades (HP:0000641)2.48917299
64Limb dystonia (HP:0002451)2.46381655
65Bradykinesia (HP:0002067)2.46253969
66Impaired vibratory sensation (HP:0002495)2.45958942
67Neurofibrillary tangles (HP:0002185)2.45929868
68Stereotypic behavior (HP:0000733)2.45900992
69Congenital primary aphakia (HP:0007707)2.45720626
70Syncope (HP:0001279)2.43216951
71Genetic anticipation (HP:0003743)2.42498427
72Acute encephalopathy (HP:0006846)2.41515379
73Scanning speech (HP:0002168)2.39268178
74Testicular atrophy (HP:0000029)2.37675024
75Hemiparesis (HP:0001269)2.36155878
76Sclerocornea (HP:0000647)2.32167877
77Spastic gait (HP:0002064)2.30060173
78Nephrogenic diabetes insipidus (HP:0009806)2.29825183
79Abolished electroretinogram (ERG) (HP:0000550)2.29156272
80Abnormality of the middle phalanges of the toes (HP:0010183)2.27924043
81Rapidly progressive (HP:0003678)2.27723251
82Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.26479400
83Abnormality of ocular smooth pursuit (HP:0000617)2.26403385
84Insidious onset (HP:0003587)2.26082079
85Termporal pattern (HP:0011008)2.26082079
86Absent speech (HP:0001344)2.25123935
87Increased CSF lactate (HP:0002490)2.23664824
88Intention tremor (HP:0002080)2.22728150
89Abnormality of the renal cortex (HP:0011035)2.21063986
90EEG with generalized epileptiform discharges (HP:0011198)2.20128392
91Optic nerve hypoplasia (HP:0000609)2.19432937
92Abnormal EKG (HP:0003115)2.18513661
93Pointed chin (HP:0000307)2.17530139
94Symphalangism affecting the phalanges of the hand (HP:0009773)2.17410455
95Abnormality of binocular vision (HP:0011514)2.16286479
96Diplopia (HP:0000651)2.16286479
97Male pseudohermaphroditism (HP:0000037)2.15927480
98Increased hepatocellular lipid droplets (HP:0006565)2.15506536
99Genital tract atresia (HP:0001827)2.15063470
100Incomplete penetrance (HP:0003829)2.14822016
101Lower limb asymmetry (HP:0100559)2.14269707
102Humeroradial synostosis (HP:0003041)2.14224740
103Synostosis involving the elbow (HP:0003938)2.14224740
104Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.14048516
1053-Methylglutaconic aciduria (HP:0003535)2.13023475
106Septo-optic dysplasia (HP:0100842)2.12295218
107Vaginal atresia (HP:0000148)2.12183372
108Mutism (HP:0002300)2.11820250
109Aplasia/hypoplasia of the uterus (HP:0008684)2.11653318
110Status epilepticus (HP:0002133)2.10928728
111Abnormal rod and cone electroretinograms (HP:0008323)2.09916966
112Craniofacial dystonia (HP:0012179)2.09654772
113Aplasia/Hypoplasia of the tibia (HP:0005772)2.09127904
114Delusions (HP:0000746)2.07188320
115Cystic liver disease (HP:0006706)2.06389725
116Abnormality of vitamin B metabolism (HP:0004340)2.06173527
117Lower limb amyotrophy (HP:0007210)2.06101987
118Hypsarrhythmia (HP:0002521)2.05927304
119Progressive inability to walk (HP:0002505)2.05920703
120Hemiplegia (HP:0002301)2.04134267
121Exercise-induced myalgia (HP:0003738)2.03031910
122Lower limb muscle weakness (HP:0007340)2.01327825
123Generalized myoclonic seizures (HP:0002123)1.99224467
124Short tibia (HP:0005736)1.99036037
125Insomnia (HP:0100785)1.98561989
126Primary atrial arrhythmia (HP:0001692)1.98312764
127Hypoplasia of the uterus (HP:0000013)1.98151838
128Megalencephaly (HP:0001355)1.96906850
129Agitation (HP:0000713)1.96721802
130Gait ataxia (HP:0002066)1.96503842
131Lipid accumulation in hepatocytes (HP:0006561)1.96098539
132Hydroureter (HP:0000072)1.95996958
133Hepatocellular necrosis (HP:0001404)1.95696691
134Type II lissencephaly (HP:0007260)1.92750954
135Prolonged QT interval (HP:0001657)1.92598619
136Renal cortical cysts (HP:0000803)1.91982774
137Increased circulating renin level (HP:0000848)1.90752982
138Abnormality of the proximal phalanges of the hand (HP:0009834)1.89265141
139Abnormality of alanine metabolism (HP:0010916)1.87973912
140Hyperalaninemia (HP:0003348)1.87973912
141Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87973912
142Abnormality of the vitamin B12 metabolism (HP:0004341)1.86664712
143Aplasia/Hypoplasia of the tongue (HP:0010295)1.85977142
144Hypoplasia of the fovea (HP:0007750)1.85684558
145Aplasia/Hypoplasia of the fovea (HP:0008060)1.85684558
146Psychosis (HP:0000709)1.85683204
147Supraventricular tachycardia (HP:0004755)1.84208607
148Decreased circulating renin level (HP:0003351)1.83946881
149Hypothermia (HP:0002045)1.82321238
150Atrial fibrillation (HP:0005110)1.82093995
151Global brain atrophy (HP:0002283)1.81988186
152Aplasia/Hypoplasia of the hallux (HP:0008362)1.81947534
153Absent phalangeal crease (HP:0006109)1.81877608
154Ankyloglossia (HP:0010296)1.81511547
155Anosmia (HP:0000458)1.80925442
156Pheochromocytoma (HP:0002666)1.80589189
157Blue irides (HP:0000635)1.80346503
158Poor suck (HP:0002033)1.80264674
159Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79182848
160Adrenal hypoplasia (HP:0000835)1.78859291
161Anencephaly (HP:0002323)1.78672926
162Supraventricular arrhythmia (HP:0005115)1.78588968
163Papilledema (HP:0001085)1.78333527
164Palpebral edema (HP:0100540)1.77713098
165Specific learning disability (HP:0001328)1.77660175
166Congenital sensorineural hearing impairment (HP:0008527)1.77340680
167Short hallux (HP:0010109)1.76107616
168Increased corneal curvature (HP:0100692)1.76017446
169Keratoconus (HP:0000563)1.76017446
170Renal Fanconi syndrome (HP:0001994)1.75462372
171Abnormality of salivation (HP:0100755)1.75432913
172Resting tremor (HP:0002322)1.74960843
173Congenital, generalized hypertrichosis (HP:0004540)1.74767358
174Abnormality of glycine metabolism (HP:0010895)1.72820064
175Abnormality of serine family amino acid metabolism (HP:0010894)1.72820064
176Hepatic necrosis (HP:0002605)1.72759756
177Attenuation of retinal blood vessels (HP:0007843)1.72511086
178Poor coordination (HP:0002370)1.71443778
179Optic disc pallor (HP:0000543)1.71047195
180Polyphagia (HP:0002591)1.70633259
181Decreased central vision (HP:0007663)1.70015585
182Colon cancer (HP:0003003)1.69288312
183Type 2 muscle fiber atrophy (HP:0003554)1.68438380
184Abnormality of the phalanges of the 2nd finger (HP:0009541)1.67729249
185Lissencephaly (HP:0001339)1.66209198
186Fibular aplasia (HP:0002990)1.65195655
187Bony spicule pigmentary retinopathy (HP:0007737)1.65097797
188Abnormality of serum amino acid levels (HP:0003112)1.64660370

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.27870234
2NTRK35.29864693
3FRK4.10011213
4MAP3K93.24282250
5RIPK43.07919011
6WNK32.73224824
7GRK12.68817206
8MAP3K42.60684974
9KSR22.57842505
10PRKD32.55867334
11MINK12.54787642
12MAP4K22.54545141
13DAPK22.31960706
14MAP2K72.00721958
15DYRK21.96126534
16KSR11.91256482
17ZAK1.89868220
18ADRBK21.88242862
19PAK61.87421369
20TLK11.84813366
21DAPK11.82757307
22MAP3K121.73740826
23PTK2B1.73063272
24MAP2K41.69483281
25CAMKK11.65904061
26BMPR1B1.63732127
27FGFR21.60613157
28ARAF1.57855187
29PRPF4B1.56133469
30MAP3K131.54595591
31MARK11.49114722
32FES1.48420392
33STK381.46410229
34NME11.46267088
35INSRR1.45433709
36NUAK11.45357322
37NTRK11.45020982
38CDK51.44813283
39PLK21.44024280
40OBSCN1.41614901
41GRK51.39544785
42MAP3K21.39279539
43TNIK1.39105169
44NTRK21.37117629
45CSNK1G21.32522954
46BMPR21.30580421
47STK161.25501106
48CAMK2B1.24338124
49PRKCG1.20060092
50CAMK2A1.17828218
51TYRO31.17788717
52PNCK1.16957474
53MKNK21.15928564
54RAF11.13689253
55SIK21.12062767
56TAOK31.10741379
57CSNK1G11.10323367
58TRIM281.09674340
59CSNK1G31.08377240
60MUSK1.05538412
61CAMK11.02414362
62CASK0.99261787
63LMTK20.98461252
64BCKDK0.98081813
65PLK30.96773410
66VRK10.95613795
67MAP3K70.93910882
68PINK10.86133512
69STK390.83284844
70PDK10.80010999
71CDK190.78412306
72PAK30.77581331
73DMPK0.75616815
74SGK4940.74284877
75SGK2230.74284877
76VRK20.73994525
77PHKG20.73765133
78PHKG10.73765133
79CSNK1A1L0.73193554
80SGK10.72829678
81ACVR1B0.72811596
82MAPK130.72392021
83NEK10.72390608
84SGK20.71911700
85STK110.71154817
86CDK180.70884709
87FER0.70816789
88MAP3K10.69479967
89PDPK10.69409350
90RET0.69308607
91TIE10.68551460
92CDK150.68057447
93LATS20.67654963
94CAMK2D0.67015816
95PRKCH0.66409730
96CDK140.66373017
97PKN10.65988379
98PLK40.64255270
99FGR0.64170621
100LIMK10.63883184
101ADRBK10.62500702
102SGK30.62007423
103CSNK1A10.59528030
104TAOK10.59171634
105BCR0.59047255
106CDK11A0.58536156
107UHMK10.57751021
108MARK20.57705977
109DYRK1A0.55439806
110MAPKAPK30.55060827
111MAPK150.52962660
112CAMKK20.52841213
113MAP2K10.52353530
114CAMK2G0.48899814
115EPHB20.48767539
116ERBB30.48520916
117TNK20.48406902
118CAMK40.48323394
119CDC70.47637293
120PRKCE0.47588787
121DYRK30.46549471
122PDK20.45126759
123RPS6KA30.44930445
124PLK10.44759533
125PRKG10.44518328
126TXK0.43960584
127PRKCZ0.43213046
128MKNK10.42950147
129FYN0.42557849
130PRKD20.42067122
131CDC42BPA0.41207784
132OXSR10.41002565
133TSSK60.39405722
134MAPK100.38152612
135SIK30.37958359
136CAMK1G0.37493921
137PRKACB0.37434112
138CSNK1E0.37403502
139CSNK1D0.36014089
140ALK0.35191051
141CCNB10.34575130
142MAPKAPK50.34546735
143PRKACG0.34267226
144BRAF0.33638858
145DAPK30.32445824
146WNK40.31673816
147ROCK20.31271669
148RIPK10.30078194
149NEK60.29729349
150PRKCA0.29295426
151GRK70.28723889
152PRKACA0.28481685
153PRKCB0.28475938
154MOS0.28440128

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.67940644
2Long-term potentiation_Homo sapiens_hsa047203.20981268
3Oxidative phosphorylation_Homo sapiens_hsa001903.09175469
4Circadian entrainment_Homo sapiens_hsa047132.90553176
5Amphetamine addiction_Homo sapiens_hsa050312.80772547
6Olfactory transduction_Homo sapiens_hsa047402.73067522
7Glutamatergic synapse_Homo sapiens_hsa047242.67129516
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.63030673
9Synaptic vesicle cycle_Homo sapiens_hsa047212.62971899
10Parkinsons disease_Homo sapiens_hsa050122.57590482
11GABAergic synapse_Homo sapiens_hsa047272.38193883
12Morphine addiction_Homo sapiens_hsa050322.36470351
13Salivary secretion_Homo sapiens_hsa049702.35255576
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.34011397
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.31494978
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.24986203
17Dopaminergic synapse_Homo sapiens_hsa047282.17888300
18Aldosterone synthesis and secretion_Homo sapiens_hsa049252.05226521
19Gastric acid secretion_Homo sapiens_hsa049712.02424319
20Insulin secretion_Homo sapiens_hsa049111.93622890
21Protein export_Homo sapiens_hsa030601.91428382
22Calcium signaling pathway_Homo sapiens_hsa040201.90767496
23Renin secretion_Homo sapiens_hsa049241.85289453
24Cholinergic synapse_Homo sapiens_hsa047251.83964434
25Oxytocin signaling pathway_Homo sapiens_hsa049211.81452298
26Butanoate metabolism_Homo sapiens_hsa006501.78961884
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72562059
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.68831898
29Taste transduction_Homo sapiens_hsa047421.68463804
30Long-term depression_Homo sapiens_hsa047301.67856998
31Huntingtons disease_Homo sapiens_hsa050161.67443339
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.61662317
33RNA polymerase_Homo sapiens_hsa030201.56460958
34GnRH signaling pathway_Homo sapiens_hsa049121.54894376
35Serotonergic synapse_Homo sapiens_hsa047261.53826834
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.51253926
37Cocaine addiction_Homo sapiens_hsa050301.46286628
38Linoleic acid metabolism_Homo sapiens_hsa005911.43484534
39cAMP signaling pathway_Homo sapiens_hsa040241.42281578
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41398763
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39533836
42Propanoate metabolism_Homo sapiens_hsa006401.32728395
43Basal transcription factors_Homo sapiens_hsa030221.28411295
44RNA degradation_Homo sapiens_hsa030181.28215098
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27246263
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27166142
47Sulfur metabolism_Homo sapiens_hsa009201.25856465
48Gap junction_Homo sapiens_hsa045401.25610736
49Glioma_Homo sapiens_hsa052141.24483144
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22948447
51Selenocompound metabolism_Homo sapiens_hsa004501.22754376
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21184531
53cGMP-PKG signaling pathway_Homo sapiens_hsa040221.21011175
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20666979
55Collecting duct acid secretion_Homo sapiens_hsa049661.16870549
56Tryptophan metabolism_Homo sapiens_hsa003801.16722943
57Cardiac muscle contraction_Homo sapiens_hsa042601.15537502
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15374609
59Homologous recombination_Homo sapiens_hsa034401.14288299
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12890031
61Axon guidance_Homo sapiens_hsa043601.11627228
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10422905
63Vascular smooth muscle contraction_Homo sapiens_hsa042701.08894586
64Melanogenesis_Homo sapiens_hsa049161.08692530
65Type II diabetes mellitus_Homo sapiens_hsa049301.08224032
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.06880878
67Estrogen signaling pathway_Homo sapiens_hsa049151.06579019
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04828331
69Fanconi anemia pathway_Homo sapiens_hsa034601.04425681
70Ether lipid metabolism_Homo sapiens_hsa005651.04383925
71Nitrogen metabolism_Homo sapiens_hsa009101.01270118
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98132774
73Peroxisome_Homo sapiens_hsa041460.97165428
74Caffeine metabolism_Homo sapiens_hsa002320.95345750
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94377134
76ErbB signaling pathway_Homo sapiens_hsa040120.94027744
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93878252
78Pancreatic secretion_Homo sapiens_hsa049720.93630117
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93150554
80Chemical carcinogenesis_Homo sapiens_hsa052040.92132847
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90726386
82Pyruvate metabolism_Homo sapiens_hsa006200.90234047
83Steroid biosynthesis_Homo sapiens_hsa001000.89687234
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89498690
85Proteasome_Homo sapiens_hsa030500.89488513
86Retinol metabolism_Homo sapiens_hsa008300.89421830
87Dilated cardiomyopathy_Homo sapiens_hsa054140.88159551
88VEGF signaling pathway_Homo sapiens_hsa043700.87718217
89Dorso-ventral axis formation_Homo sapiens_hsa043200.87645432
90Oocyte meiosis_Homo sapiens_hsa041140.85803920
91Fatty acid elongation_Homo sapiens_hsa000620.85097457
92Regulation of autophagy_Homo sapiens_hsa041400.84750665
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.84390563
94Choline metabolism in cancer_Homo sapiens_hsa052310.82296299
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81895214
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81096629
97Thyroid hormone synthesis_Homo sapiens_hsa049180.81076200
98Vitamin B6 metabolism_Homo sapiens_hsa007500.79806236
99Ribosome_Homo sapiens_hsa030100.79677454
100beta-Alanine metabolism_Homo sapiens_hsa004100.78508528
101Glucagon signaling pathway_Homo sapiens_hsa049220.78468852
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75707329
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.75247751
104Fat digestion and absorption_Homo sapiens_hsa049750.72247584
105Purine metabolism_Homo sapiens_hsa002300.70505314
106Hedgehog signaling pathway_Homo sapiens_hsa043400.69251159
107Metabolic pathways_Homo sapiens_hsa011000.67757469
108African trypanosomiasis_Homo sapiens_hsa051430.67671072
109Vibrio cholerae infection_Homo sapiens_hsa051100.67255230
110Vitamin digestion and absorption_Homo sapiens_hsa049770.66094853
111Glycerolipid metabolism_Homo sapiens_hsa005610.65649841
112Phototransduction_Homo sapiens_hsa047440.65192844
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65027030
114Rap1 signaling pathway_Homo sapiens_hsa040150.64485716
115MAPK signaling pathway_Homo sapiens_hsa040100.61501664
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60299102
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59405822
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58544245
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.58494011
120Bile secretion_Homo sapiens_hsa049760.58137421
121Basal cell carcinoma_Homo sapiens_hsa052170.57845947
122Histidine metabolism_Homo sapiens_hsa003400.57107417
123One carbon pool by folate_Homo sapiens_hsa006700.56917947
124Alzheimers disease_Homo sapiens_hsa050100.56782087
125Ras signaling pathway_Homo sapiens_hsa040140.56014508
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56001494
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54266956
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.53692856
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50316985
130Folate biosynthesis_Homo sapiens_hsa007900.48803684
131Inositol phosphate metabolism_Homo sapiens_hsa005620.48549700
132mTOR signaling pathway_Homo sapiens_hsa041500.47622667
133Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46987377
134Non-small cell lung cancer_Homo sapiens_hsa052230.46657887
135Primary bile acid biosynthesis_Homo sapiens_hsa001200.45854163
136Arginine and proline metabolism_Homo sapiens_hsa003300.45784714
137Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45756606
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.42371022
139Pyrimidine metabolism_Homo sapiens_hsa002400.41286959
140Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40669920
141Prion diseases_Homo sapiens_hsa050200.38461184
142Wnt signaling pathway_Homo sapiens_hsa043100.38069847
143Arginine biosynthesis_Homo sapiens_hsa002200.37118509
144Circadian rhythm_Homo sapiens_hsa047100.35272997
145Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33953257
146Insulin signaling pathway_Homo sapiens_hsa049100.33058079
147* Endocytosis_Homo sapiens_hsa041440.31001110
148Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29885390
149Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28759403
150Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28096952
151Alcoholism_Homo sapiens_hsa050340.27392590
152Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26589674
153Mineral absorption_Homo sapiens_hsa049780.26498690
154Ovarian steroidogenesis_Homo sapiens_hsa049130.26202869
155Type I diabetes mellitus_Homo sapiens_hsa049400.25461857
156Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24186645
157Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22929794
158Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22882616
159Chemokine signaling pathway_Homo sapiens_hsa040620.20866312
160Renal cell carcinoma_Homo sapiens_hsa052110.20500110
161Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.19013931
162Glycerophospholipid metabolism_Homo sapiens_hsa005640.18566513

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