WIPF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female receptivity (GO:0045924)9.84733961
2female mating behavior (GO:0060180)8.40112913
3behavioral response to nicotine (GO:0035095)5.84891777
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.74384159
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.44456075
6positive regulation of fatty acid beta-oxidation (GO:0032000)4.34402478
7synaptic vesicle maturation (GO:0016188)4.29045426
8locomotory exploration behavior (GO:0035641)4.27618487
9adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.26982681
10ionotropic glutamate receptor signaling pathway (GO:0035235)4.20575779
11vocalization behavior (GO:0071625)4.18526189
12serotonin metabolic process (GO:0042428)4.15344310
13synaptic vesicle exocytosis (GO:0016079)4.14132591
14multicellular organismal reproductive behavior (GO:0033057)4.12281907
15positive regulation of fatty acid oxidation (GO:0046321)4.10773528
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.01587665
17neuron cell-cell adhesion (GO:0007158)3.95792366
18L-amino acid import (GO:0043092)3.94995296
19neuronal action potential propagation (GO:0019227)3.91118289
20primary amino compound metabolic process (GO:1901160)3.77897736
21otic vesicle formation (GO:0030916)3.68994920
22cellular potassium ion homeostasis (GO:0030007)3.68951965
23central nervous system myelination (GO:0022010)3.68670814
24axon ensheathment in central nervous system (GO:0032291)3.68670814
25regulation of glutamate receptor signaling pathway (GO:1900449)3.68469828
26glutamate secretion (GO:0014047)3.68028170
27positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.67124900
28glutamate receptor signaling pathway (GO:0007215)3.65704122
29regulation of synaptic vesicle exocytosis (GO:2000300)3.65062639
30phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.61090328
31protein localization to synapse (GO:0035418)3.54851846
32presynaptic membrane assembly (GO:0097105)3.53728601
33regulation of neuronal synaptic plasticity (GO:0048168)3.47205229
34gamma-aminobutyric acid signaling pathway (GO:0007214)3.45358638
35presynaptic membrane organization (GO:0097090)3.44323577
36synaptic vesicle docking involved in exocytosis (GO:0016081)3.43584039
37synaptic transmission, glutamatergic (GO:0035249)3.43300932
38cell proliferation in forebrain (GO:0021846)3.40671799
39regulation of long-term neuronal synaptic plasticity (GO:0048169)3.38843435
40multicellular organism reproduction (GO:0032504)3.33807085
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.32907559
42long-term memory (GO:0007616)3.31604641
43neuron-neuron synaptic transmission (GO:0007270)3.27036280
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.25863220
45lung epithelial cell differentiation (GO:0060487)3.25359038
46regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.22258329
47regulation of synaptic vesicle transport (GO:1902803)3.20686745
48cerebellar Purkinje cell differentiation (GO:0021702)3.19597193
49cerebellar granule cell differentiation (GO:0021707)3.17967934
50long-term synaptic potentiation (GO:0060291)3.17396402
51negative regulation of appetite (GO:0032099)3.17365953
52negative regulation of response to food (GO:0032096)3.17365953
53amino acid import (GO:0043090)3.16250492
54negative regulation of synaptic transmission, GABAergic (GO:0032229)3.14889670
55exploration behavior (GO:0035640)3.10390516
56negative regulation of neurotransmitter transport (GO:0051589)3.09554825
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.08971188
58multi-organism reproductive behavior (GO:0044705)3.07409707
59RNA localization (GO:0006403)3.07270039
60sodium ion export (GO:0071436)3.03893147
61regulation of excitatory postsynaptic membrane potential (GO:0060079)3.02612593
62dendritic spine morphogenesis (GO:0060997)3.00351726
63regulation of acrosome reaction (GO:0060046)2.99808829
64startle response (GO:0001964)2.99556867
65indolalkylamine metabolic process (GO:0006586)2.97908282
66neurotransmitter secretion (GO:0007269)2.95988163
67regulation of synaptic plasticity (GO:0048167)2.94305293
68regulation of postsynaptic membrane potential (GO:0060078)2.93801400
69positive regulation of membrane potential (GO:0045838)2.93361624
70response to histamine (GO:0034776)2.93069493
71reproductive behavior (GO:0019098)2.92699724
72transmission of nerve impulse (GO:0019226)2.92328665
73lung cell differentiation (GO:0060479)2.92212805
74regulation of female gonad development (GO:2000194)2.91302803
75long-chain fatty acid biosynthetic process (GO:0042759)2.89927978
76negative regulation of keratinocyte proliferation (GO:0010839)2.88192331
77negative regulation of T cell receptor signaling pathway (GO:0050860)2.88029534
78adult walking behavior (GO:0007628)2.87452017
79membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.84935787
80relaxation of smooth muscle (GO:0044557)2.83029465
81neurotransmitter-gated ion channel clustering (GO:0072578)2.81944873
82regulation of fatty acid beta-oxidation (GO:0031998)2.81083414
83membrane depolarization during action potential (GO:0086010)2.80349567
84membrane hyperpolarization (GO:0060081)2.80234916
85negative regulation of neurotransmitter secretion (GO:0046929)2.79054482
86cellular response to exogenous dsRNA (GO:0071360)2.78967344
87neuron recognition (GO:0008038)2.78898009
88postsynaptic membrane organization (GO:0001941)2.78396581
89cartilage condensation (GO:0001502)2.77162983
90cell aggregation (GO:0098743)2.77162983
91synaptic vesicle endocytosis (GO:0048488)2.76649334
92G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.75054159
93regulation of vesicle fusion (GO:0031338)2.74190449
94auditory behavior (GO:0031223)2.74081460
95negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.71971909
96neurotransmitter transport (GO:0006836)2.71868001
97gamma-aminobutyric acid transport (GO:0015812)2.69900558
98neurotransmitter uptake (GO:0001504)2.69864348
99synaptic transmission, dopaminergic (GO:0001963)2.68733251
100response to auditory stimulus (GO:0010996)2.68194675
101mechanosensory behavior (GO:0007638)2.67360187
102pattern specification involved in kidney development (GO:0061004)2.66557297
103regulation of neurotransmitter secretion (GO:0046928)2.66530000
104regulation of synaptic transmission, glutamatergic (GO:0051966)2.65047802
105potassium ion import (GO:0010107)2.64966705
106negative regulation of T cell differentiation in thymus (GO:0033085)2.64012501
107positive regulation of cardiac muscle cell differentiation (GO:2000727)2.63855469
108regulation of respiratory system process (GO:0044065)2.63765466
109regulation of synapse maturation (GO:0090128)2.63759736
110learning (GO:0007612)2.63647761
111regulation of rhodopsin mediated signaling pathway (GO:0022400)2.60613310
112interferon-gamma secretion (GO:0072643)2.60059045
113positive regulation of synaptic transmission, GABAergic (GO:0032230)2.59856073
114multicellular organismal signaling (GO:0035637)2.59338165
115positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.58857482
116indole-containing compound metabolic process (GO:0042430)2.58018596
117neuronal ion channel clustering (GO:0045161)2.56768006
118regulation of voltage-gated calcium channel activity (GO:1901385)2.56390921
119neuromuscular process controlling posture (GO:0050884)2.55934728
120positive regulation of synaptic transmission (GO:0050806)2.55652400
121regulation of dendritic spine morphogenesis (GO:0061001)2.55460429
122regulation of synaptic transmission, GABAergic (GO:0032228)2.54544049
123positive regulation of neurotransmitter secretion (GO:0001956)2.54439026
124membrane repolarization during action potential (GO:0086011)2.54334879
125regulation of hippo signaling (GO:0035330)2.54191363
126potassium ion homeostasis (GO:0055075)2.54051470
127negative regulation of sodium ion transport (GO:0010766)2.53467752
128negative regulation of systemic arterial blood pressure (GO:0003085)2.52868399
129negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.52768218
130negative regulation of amino acid transport (GO:0051956)2.52107506
131segment specification (GO:0007379)2.50496114
132layer formation in cerebral cortex (GO:0021819)2.50256061
133regulation of G0 to G1 transition (GO:0070316)2.49463353
134regulation of neurotransmitter transport (GO:0051588)2.48193290
135regulation of respiratory gaseous exchange (GO:0043576)2.47926993
136substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.46823182
137substrate-independent telencephalic tangential migration (GO:0021826)2.46823182
138axonal fasciculation (GO:0007413)2.46701168
139positive regulation of neurotransmitter transport (GO:0051590)2.46587154
140regulation of synaptic transmission (GO:0050804)2.45635677
141response to amphetamine (GO:0001975)2.45338562
142positive regulation of action potential (GO:0045760)2.44159582
143regulation of dendritic spine development (GO:0060998)2.43872005
144cell differentiation in hindbrain (GO:0021533)2.42698189
145membrane depolarization (GO:0051899)2.42692837
146cerebral cortex radially oriented cell migration (GO:0021799)2.42564740
147negative regulation of protein localization to cell surface (GO:2000009)2.42040779
148neuronal action potential (GO:0019228)2.41511040
149sulfation (GO:0051923)2.41326304
150positive regulation of defense response to virus by host (GO:0002230)2.41160210
151rhodopsin mediated signaling pathway (GO:0016056)2.39255329
152visual learning (GO:0008542)2.38892757
153nerve growth factor signaling pathway (GO:0038180)2.38599967
154synapse assembly (GO:0007416)2.38047271
155tooth mineralization (GO:0034505)2.37551858
156DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.37540713
157regulation of neurotransmitter levels (GO:0001505)2.36782640
158long term synaptic depression (GO:0060292)2.36409774
159positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.35855174
160associative learning (GO:0008306)2.35328524
161cellular response to ATP (GO:0071318)2.35287656
162regulation of action potential (GO:0098900)2.33966372
163negative regulation of DNA-templated transcription, elongation (GO:0032785)2.33441652
164ovulation cycle (GO:0042698)2.33399851
165positive regulation of synapse maturation (GO:0090129)2.32538267
166cellular response to electrical stimulus (GO:0071257)2.31853185
167negative regulation of blood pressure (GO:0045776)2.30698536
168ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.30659052
169regulation of calcium ion-dependent exocytosis (GO:0017158)2.30134596
170negative regulation of response to nutrient levels (GO:0032108)2.29238927
171negative regulation of response to extracellular stimulus (GO:0032105)2.29238927
172regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.26566184
173regulation of sequestering of triglyceride (GO:0010889)2.26137938
174behavioral response to cocaine (GO:0048148)2.25314288
175negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.24063503
176detection of light stimulus involved in sensory perception (GO:0050962)2.23779184
177detection of light stimulus involved in visual perception (GO:0050908)2.23779184
178negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.23159407
179parturition (GO:0007567)2.22800500
180cellular response to pH (GO:0071467)2.20718224
181tachykinin receptor signaling pathway (GO:0007217)2.19134247
182regulation of germinal center formation (GO:0002634)2.18241063
183protein-chromophore linkage (GO:0018298)2.16858112
184negative regulation of adenylate cyclase activity (GO:0007194)2.16159030
185action potential (GO:0001508)2.16043507
186dopamine receptor signaling pathway (GO:0007212)2.15349715
187negative regulation of astrocyte differentiation (GO:0048712)2.14983713
188neuron maturation (GO:0042551)2.14528162

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.03668801
2GBX2_23144817_ChIP-Seq_PC3_Human3.28375031
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.73111003
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66218915
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.61769217
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.55283031
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.37827330
8DROSHA_22980978_ChIP-Seq_HELA_Human2.26750868
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25918440
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25918440
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.25564204
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.18835715
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.12377397
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.09821422
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.09783427
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.09291789
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06180550
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.03785132
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.00320282
20RARB_27405468_Chip-Seq_BRAIN_Mouse1.99439107
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.99018042
22REST_21632747_ChIP-Seq_MESCs_Mouse1.98547393
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91716435
24AR_21572438_ChIP-Seq_LNCaP_Human1.90884645
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.90213935
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.86843066
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.80591649
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75446590
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.74614722
30* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64073525
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61387152
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55001950
33SMAD4_21799915_ChIP-Seq_A2780_Human1.54871204
34TAF15_26573619_Chip-Seq_HEK293_Human1.53872197
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51934959
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51827458
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.50558844
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.46178795
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45769810
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44884039
41P300_19829295_ChIP-Seq_ESCs_Human1.41887747
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.40272665
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39862924
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.38970380
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38214405
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37986893
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36024852
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31813722
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31040929
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28979489
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28358039
52TP53_16413492_ChIP-PET_HCT116_Human1.27951044
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.27935564
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25981939
55P53_22127205_ChIP-Seq_FIBROBLAST_Human1.25942189
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25807023
57STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.24441297
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22625372
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22070085
60STAT3_23295773_ChIP-Seq_U87_Human1.21217316
61AHR_22903824_ChIP-Seq_MCF-7_Human1.21111840
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20927378
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20728327
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.20599160
65TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19707591
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19181505
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18640267
68RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.17686286
69TDRD3_21172665_ChIP-Seq_MCF-7_Human1.17109186
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.16312250
71ESR1_21235772_ChIP-Seq_MCF-7_Human1.16134028
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14785622
73TCF4_23295773_ChIP-Seq_U87_Human1.12925771
74FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.12803385
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11809880
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11720367
77RXR_22108803_ChIP-Seq_LS180_Human1.11541696
78ER_23166858_ChIP-Seq_MCF-7_Human1.11293169
79WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11274986
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.11140869
81RNF2_27304074_Chip-Seq_NSC_Mouse1.10606537
82TP53_20018659_ChIP-ChIP_R1E_Mouse1.10327505
83AR_25329375_ChIP-Seq_VCAP_Human1.10089426
84BP1_19119308_ChIP-ChIP_Hs578T_Human1.09387767
85VDR_22108803_ChIP-Seq_LS180_Human1.09323433
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.08409381
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07852498
88RING1B_27294783_Chip-Seq_ESCs_Mouse1.07207045
89GATA1_26923725_Chip-Seq_HPCs_Mouse1.07177576
90* RING1B_27294783_Chip-Seq_NPCs_Mouse1.07043094
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05999143
92* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04087214
93* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03569856
94SOX2_21211035_ChIP-Seq_LN229_Gbm1.03098289
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02731331
96SMAD3_21741376_ChIP-Seq_HESCs_Human1.02616351
97* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02114217
98* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02114217
99AR_19668381_ChIP-Seq_PC3_Human1.02037971
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01990354
101E2F1_18555785_Chip-Seq_ESCs_Mouse1.01797740
102TP53_18474530_ChIP-ChIP_U2OS_Human1.01564673
103CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99734831
104RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98828599
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98769758
106RUNX2_22187159_ChIP-Seq_PCA_Human0.98385364
107ESR1_20079471_ChIP-ChIP_T-47D_Human0.98088421
108NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97229971
109KDM2B_26808549_Chip-Seq_K562_Human0.95158613
110NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94931808
111CMYC_18555785_Chip-Seq_ESCs_Mouse0.94605953
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94401231
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94248599
114FUS_26573619_Chip-Seq_HEK293_Human0.93770507
115OCT1_27270436_Chip-Seq_PROSTATE_Human0.92122210
116ERG_21242973_ChIP-ChIP_JURKAT_Human0.91744537
117YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91321601
118SMAD3_21741376_ChIP-Seq_ESCs_Human0.90823445
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90621714
120ZNF274_21170338_ChIP-Seq_K562_Hela0.90361882
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89629152
122SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89548047
123CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89131271
124P53_22387025_ChIP-Seq_ESCs_Mouse0.88132460
125EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.87190035
126EP300_21415370_ChIP-Seq_HL-1_Mouse0.86541865
127LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84008993
128GATA3_21878914_ChIP-Seq_MCF-7_Human0.83922387
129ZFP281_27345836_Chip-Seq_ESCs_Mouse0.82951065
130TP53_23651856_ChIP-Seq_MEFs_Mouse0.81974012
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.80945987
132OCT4_19829295_ChIP-Seq_ESCs_Human0.78991082

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.18743561
2MP0003880_abnormal_central_pattern4.86275773
3MP0003635_abnormal_synaptic_transmissio3.50976765
4MP0004270_analgesia3.17594635
5MP0009046_muscle_twitch3.15317851
6MP0005423_abnormal_somatic_nervous3.10293572
7MP0004130_abnormal_muscle_cell3.10137902
8MP0002064_seizures3.09964148
9MP0009745_abnormal_behavioral_response3.07955558
10MP0002063_abnormal_learning/memory/cond2.83385488
11MP0001486_abnormal_startle_reflex2.73772510
12MP0002272_abnormal_nervous_system2.59866915
13MP0002876_abnormal_thyroid_physiology2.54293286
14MP0002572_abnormal_emotion/affect_behav2.52992908
15MP0002822_catalepsy2.46884944
16MP0001968_abnormal_touch/_nociception2.40454584
17MP0001501_abnormal_sleep_pattern2.36844007
18MP0005409_darkened_coat_color2.35345389
19MP0002734_abnormal_mechanical_nocicepti2.09686138
20MP0008569_lethality_at_weaning2.08770824
21MP0002653_abnormal_ependyma_morphology2.07392571
22MP0001440_abnormal_grooming_behavior1.89930857
23MP0003787_abnormal_imprinting1.89696869
24MP0000920_abnormal_myelination1.87783458
25MP0002736_abnormal_nociception_after1.86392193
26MP0002067_abnormal_sensory_capabilities1.78743949
27MP0000778_abnormal_nervous_system1.75288180
28MP0004742_abnormal_vestibular_system1.74219652
29MP0004885_abnormal_endolymph1.70871232
30MP0001970_abnormal_pain_threshold1.67999630
31MP0001188_hyperpigmentation1.66921611
32MP0002735_abnormal_chemical_nociception1.63254531
33MP0003638_abnormal_response/metabolism_1.61275913
34MP0000678_abnormal_parathyroid_gland1.56284467
35MP0002733_abnormal_thermal_nociception1.55179478
36MP0005645_abnormal_hypothalamus_physiol1.54522882
37MP0002557_abnormal_social/conspecific_i1.52698997
38MP0004858_abnormal_nervous_system1.46183903
39MP0002132_abnormal_respiratory_system1.45931755
40MP0000049_abnormal_middle_ear1.45596980
41MP0003646_muscle_fatigue1.44707659
42MP0004924_abnormal_behavior1.44688566
43MP0005386_behavior/neurological_phenoty1.44688566
44MP0000230_abnormal_systemic_arterial1.40885006
45MP0002909_abnormal_adrenal_gland1.40740908
46MP0008775_abnormal_heart_ventricle1.39488532
47MP0002138_abnormal_hepatobiliary_system1.38767025
48MP0004142_abnormal_muscle_tone1.33469154
49MP0002882_abnormal_neuron_morphology1.33054280
50MP0005646_abnormal_pituitary_gland1.32332539
51MP0003633_abnormal_nervous_system1.32006618
52MP0002249_abnormal_larynx_morphology1.30782118
53MP0001905_abnormal_dopamine_level1.30569468
54MP0002089_abnormal_postnatal_growth/wei1.29879462
55MP0002163_abnormal_gland_morphology1.29409216
56MP0002184_abnormal_innervation1.28485146
57MP0009780_abnormal_chondrocyte_physiolo1.26449874
58MP0001485_abnormal_pinna_reflex1.26427794
59MP0001346_abnormal_lacrimal_gland1.25874161
60MP0004381_abnormal_hair_follicle1.25735392
61MP0001529_abnormal_vocalization1.24334877
62MP0001502_abnormal_circadian_rhythm1.23972422
63MP0002066_abnormal_motor_capabilities/c1.22408763
64MP0004811_abnormal_neuron_physiology1.20260822
65MP0000955_abnormal_spinal_cord1.20113003
66MP0004510_myositis1.20112999
67MP0001984_abnormal_olfaction1.18890618
68MP0002160_abnormal_reproductive_system1.15408906
69MP0003631_nervous_system_phenotype1.14927307
70MP0003879_abnormal_hair_cell1.14278045
71MP0005551_abnormal_eye_electrophysiolog1.12716911
72MP0003690_abnormal_glial_cell1.11787675
73MP0003136_yellow_coat_color1.10707183
74MP0002282_abnormal_trachea_morphology1.09224851
75MP0005310_abnormal_salivary_gland1.09114222
76MP0000383_abnormal_hair_follicle1.05273367
77MP0002229_neurodegeneration1.05081223
78MP0001963_abnormal_hearing_physiology1.02669071
79MP0005410_abnormal_fertilization1.01700096
80MP0003119_abnormal_digestive_system1.01386039
81MP0005360_urolithiasis0.98622893
82MP0006276_abnormal_autonomic_nervous0.98484061
83MP0000427_abnormal_hair_cycle0.97686286
84MP0000681_abnormal_thyroid_gland0.97486052
85MP0003122_maternal_imprinting0.96471560
86MP0005389_reproductive_system_phenotype0.96235453
87MP0002152_abnormal_brain_morphology0.96114272
88MP0009053_abnormal_anal_canal0.95826084
89MP0003634_abnormal_glial_cell0.93766959
90MP0003075_altered_response_to0.93595472
91MP0003329_amyloid_beta_deposits0.93366408
92MP0001765_abnormal_ion_homeostasis0.92806684
93MP0005171_absent_coat_pigmentation0.90175658
94MP0005499_abnormal_olfactory_system0.89583457
95MP0005394_taste/olfaction_phenotype0.89583457
96MP0001879_abnormal_lymphatic_vessel0.89323169
97MP0008961_abnormal_basal_metabolism0.89217229
98MP0004085_abnormal_heartbeat0.87033524
99MP0003724_increased_susceptibility_to0.85530071
100MP0000470_abnormal_stomach_morphology0.84953552
101MP0000631_abnormal_neuroendocrine_gland0.84860222
102MP0003632_abnormal_nervous_system0.84602566
103MP0000569_abnormal_digit_pigmentation0.83744987
104MP0009384_cardiac_valve_regurgitation0.83224150
105MP0003045_fibrosis0.82950093
106MP0009379_abnormal_foot_pigmentation0.80764081
107MP0006292_abnormal_olfactory_placode0.80275473
108MP0008874_decreased_physiological_sensi0.79906599
109MP0001348_abnormal_lacrimal_gland0.79829699
110MP0008872_abnormal_physiological_respon0.79291247
111MP0004019_abnormal_vitamin_homeostasis0.78240041
112MP0008004_abnormal_stomach_pH0.77403743
113MP0009250_abnormal_appendicular_skeleto0.76595034
114MP0002752_abnormal_somatic_nervous0.76251560
115MP0003303_peritoneal_inflammation0.75405409
116MP0003718_maternal_effect0.74988987
117MP0000566_synostosis0.74776624
118MP0000534_abnormal_ureter_morphology0.74209460
119MP0008877_abnormal_DNA_methylation0.73873558
120MP0005671_abnormal_response_to0.73358713
121MP0001177_atelectasis0.73270041
122MP0003950_abnormal_plasma_membrane0.73019915
123MP0010329_abnormal_lipoprotein_level0.70344313
124MP0005187_abnormal_penis_morphology0.70046430
125MP0001664_abnormal_digestion0.69016702
126MP0002069_abnormal_eating/drinking_beha0.68567390
127MP0002116_abnormal_craniofacial_bone0.68330836
128MP0010030_abnormal_orbit_morphology0.67876834
129MP0005387_immune_system_phenotype0.67379102
130MP0001790_abnormal_immune_system0.67379102
131MP0005167_abnormal_blood-brain_barrier0.67275292
132MP0000015_abnormal_ear_pigmentation0.66461431
133MP0003942_abnormal_urinary_system0.66270268
134MP0000026_abnormal_inner_ear0.64734569
135MP0000372_irregular_coat_pigmentation0.64572472
136MP0000163_abnormal_cartilage_morphology0.64395121
137MP0005174_abnormal_tail_pigmentation0.64331994
138MP0003938_abnormal_ear_development0.63782889
139MP0005377_hearing/vestibular/ear_phenot0.62848639
140MP0000516_abnormal_urinary_system0.62138946
141MP0005367_renal/urinary_system_phenotyp0.62138946
142MP0002148_abnormal_hypersensitivity_rea0.60555914
143MP0001851_eye_inflammation0.60421835
144MP0002277_abnormal_respiratory_mucosa0.59115270
145MP0010678_abnormal_skin_adnexa0.58629811
146MP0003183_abnormal_peptide_metabolism0.57851084
147MP0005000_abnormal_immune_tolerance0.55021297

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.33877015
2Concave nail (HP:0001598)5.24941318
3Myokymia (HP:0002411)4.65639945
4Focal seizures (HP:0007359)4.58471584
5Febrile seizures (HP:0002373)4.21153021
6Epileptic encephalopathy (HP:0200134)4.20550703
7Progressive cerebellar ataxia (HP:0002073)4.08394619
8Congenital stationary night blindness (HP:0007642)3.86591636
9Atonic seizures (HP:0010819)3.64774383
10Conical tooth (HP:0000698)3.33777844
11Broad-based gait (HP:0002136)3.27017445
12Dialeptic seizures (HP:0011146)3.23707551
13Visual hallucinations (HP:0002367)3.20878680
14Diplopia (HP:0000651)3.19235093
15Abnormality of binocular vision (HP:0011514)3.19235093
16Severe visual impairment (HP:0001141)3.18839465
17Absence seizures (HP:0002121)3.15726225
18Genetic anticipation (HP:0003743)3.12457333
19Supranuclear gaze palsy (HP:0000605)3.09722523
20Mesangial abnormality (HP:0001966)3.07795618
21Tubular atrophy (HP:0000092)3.07241283
22Abnormality of the proximal phalanges of the hand (HP:0009834)3.03370234
23Action tremor (HP:0002345)3.01508439
24Dysmetria (HP:0001310)2.95654487
25Short femoral neck (HP:0100864)2.94472316
26Generalized tonic-clonic seizures (HP:0002069)2.91252184
27Gaze-evoked nystagmus (HP:0000640)2.88086163
28Abnormal hair whorl (HP:0010721)2.87121783
29Abnormal rod and cone electroretinograms (HP:0008323)2.85949237
30True hermaphroditism (HP:0010459)2.82652472
31Peripheral hypomyelination (HP:0007182)2.78368139
32Fibular hypoplasia (HP:0003038)2.70208297
33Thyroid-stimulating hormone excess (HP:0002925)2.66823961
34Lip pit (HP:0100267)2.66133895
35Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.65301691
36Decreased circulating renin level (HP:0003351)2.64039258
37Hemiparesis (HP:0001269)2.61043906
38Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.60663302
39Short 4th metacarpal (HP:0010044)2.60663302
40Pancreatic cysts (HP:0001737)2.59702827
41Tibial bowing (HP:0002982)2.56503499
42Dysdiadochokinesis (HP:0002075)2.55462571
43Osteomalacia (HP:0002749)2.55454067
44Parakeratosis (HP:0001036)2.53248301
45Urinary bladder sphincter dysfunction (HP:0002839)2.50146543
46Neurofibrillary tangles (HP:0002185)2.48762058
47Degeneration of the lateral corticospinal tracts (HP:0002314)2.45527863
48Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.45527863
49Abnormality of the phalanges of the 2nd finger (HP:0009541)2.43645419
50Widely spaced teeth (HP:0000687)2.42164829
51Decreased central vision (HP:0007663)2.41574178
52Absent speech (HP:0001344)2.37854369
53Aplasia/Hypoplasia of the fibula (HP:0006492)2.36936432
54Truncal ataxia (HP:0002078)2.36616443
55Hemiplegia (HP:0002301)2.36584345
56Hypoplastic iliac wings (HP:0002866)2.34989003
57Aplasia/Hypoplasia of the patella (HP:0006498)2.32642261
58Hypoplasia of the fovea (HP:0007750)2.30581593
59Aplasia/Hypoplasia of the fovea (HP:0008060)2.30581593
6011 pairs of ribs (HP:0000878)2.28403448
61Drooling (HP:0002307)2.28102362
62Excessive salivation (HP:0003781)2.28102362
63Stereotypic behavior (HP:0000733)2.25203508
64Progressive inability to walk (HP:0002505)2.24541282
65Abnormality of the corticospinal tract (HP:0002492)2.23926810
66Abnormality of the renal cortex (HP:0011035)2.21516767
67Clumsiness (HP:0002312)2.20681598
68Thickened helices (HP:0000391)2.19275609
69Spastic gait (HP:0002064)2.17989738
70Megalencephaly (HP:0001355)2.17478882
71Bony spicule pigmentary retinopathy (HP:0007737)2.17414738
72Pancreatic fibrosis (HP:0100732)2.16896183
73Patellar aplasia (HP:0006443)2.16292135
74Hyperventilation (HP:0002883)2.15537318
75Neonatal short-limb short stature (HP:0008921)2.14768488
76Stomach cancer (HP:0012126)2.14765405
77Obstructive sleep apnea (HP:0002870)2.13906663
78Aqueductal stenosis (HP:0002410)2.10858353
79Postural instability (HP:0002172)2.10842865
80Abnormal eating behavior (HP:0100738)2.10784730
81Ankle clonus (HP:0011448)2.09616472
82Hypoplasia of the ulna (HP:0003022)2.08908600
83Increased corneal curvature (HP:0100692)2.08070372
84Keratoconus (HP:0000563)2.08070372
85Nephronophthisis (HP:0000090)2.07503093
86Morphological abnormality of the middle ear (HP:0008609)2.06628397
87Intention tremor (HP:0002080)2.06604893
88Abnormality of the renal medulla (HP:0100957)2.05945962
89Slow saccadic eye movements (HP:0000514)2.04585062
90Synostosis of carpal bones (HP:0005048)2.03905017
91Dynein arm defect of respiratory motile cilia (HP:0012255)2.03287779
92Absent/shortened dynein arms (HP:0200106)2.03287779
93Stomatitis (HP:0010280)2.02329669
94Pendular nystagmus (HP:0012043)2.01202754
95Abnormality of the fibula (HP:0002991)2.00468750
96Aplasia/hypoplasia of the femur (HP:0005613)1.99611880
97Abnormality of the 4th metacarpal (HP:0010012)1.99220525
98Optic nerve hypoplasia (HP:0000609)1.98675745
99Abolished electroretinogram (ERG) (HP:0000550)1.98493742
100Bowel incontinence (HP:0002607)1.98214123
101Aplasia/Hypoplasia of the tibia (HP:0005772)1.97673790
102Type II lissencephaly (HP:0007260)1.97375839
103Bronchomalacia (HP:0002780)1.97256581
104Sensory axonal neuropathy (HP:0003390)1.96404249
105Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.95645496
106Anhidrosis (HP:0000970)1.94395970
107Supernumerary bones of the axial skeleton (HP:0009144)1.94313562
108Abnormality of the 2nd finger (HP:0004100)1.94150156
109Short hallux (HP:0010109)1.94060967
110Split foot (HP:0001839)1.93664658
111Abnormal large intestine physiology (HP:0012700)1.93633352
112Cerebral inclusion bodies (HP:0100314)1.93316202
113Keratoconjunctivitis (HP:0001096)1.93172165
114Onion bulb formation (HP:0003383)1.92117870
115Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.91392440
116Short chin (HP:0000331)1.90945722
117Impaired vibration sensation in the lower limbs (HP:0002166)1.90682131
118Scanning speech (HP:0002168)1.89269991
119Hypoalbuminemia (HP:0003073)1.89056165
120Abnormal albumin level (HP:0012116)1.89056165
121Abnormality of the middle phalanges of the toes (HP:0010183)1.88437761
122Abnormality of midbrain morphology (HP:0002418)1.87126591
123Molar tooth sign on MRI (HP:0002419)1.87126591
124Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85623143
125Keratoconjunctivitis sicca (HP:0001097)1.85416805
126Abnormality of salivation (HP:0100755)1.85111763
127Hypotrichosis (HP:0001006)1.84394053
128Attenuation of retinal blood vessels (HP:0007843)1.84293258
129Oligodactyly (hands) (HP:0001180)1.84215925
130Impaired smooth pursuit (HP:0007772)1.81019361
131Depression (HP:0000716)1.79285655
132Papilledema (HP:0001085)1.79065970
133Premature skin wrinkling (HP:0100678)1.78939284
134Aplasia/Hypoplasia of the ulna (HP:0006495)1.78461279
135Aplasia involving bones of the upper limbs (HP:0009823)1.78246830
136Aplasia of the phalanges of the hand (HP:0009802)1.78246830
137Aplasia involving bones of the extremities (HP:0009825)1.78246830
138Genu varum (HP:0002970)1.78199389
139Cystic liver disease (HP:0006706)1.78157888
140Aplasia/Hypoplasia of the hallux (HP:0008362)1.74299927
141Agitation (HP:0000713)1.74036281
142Amblyopia (HP:0000646)1.72771376
143Generalized myoclonic seizures (HP:0002123)1.71625616
144Pigmentary retinal degeneration (HP:0001146)1.71577311
145Anxiety (HP:0000739)1.70760429
146Asplenia (HP:0001746)1.70748252
147Congenital, generalized hypertrichosis (HP:0004540)1.70327425
148Abnormality of the nasal septum (HP:0000419)1.67358957
149Mutism (HP:0002300)1.64565796
150Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.63345701
151Congenital sensorineural hearing impairment (HP:0008527)1.62987317
152Obstructive lung disease (HP:0006536)1.62191972
153Chronic obstructive pulmonary disease (HP:0006510)1.62191972
154Inability to walk (HP:0002540)1.62031857
155Lower limb muscle weakness (HP:0007340)1.60423005
156Poor eye contact (HP:0000817)1.59856603
157Metabolic alkalosis (HP:0200114)1.59264168
158Gastroesophageal reflux (HP:0002020)1.57920834
159Oligodontia (HP:0000677)1.57338702
160Blue irides (HP:0000635)1.56598066
161Abnormality of saccadic eye movements (HP:0000570)1.56529445
162Ventricular fibrillation (HP:0001663)1.55965420
163Deeply set eye (HP:0000490)1.55836801
164Abnormal social behavior (HP:0012433)1.55697510
165Impaired social interactions (HP:0000735)1.55697510
166Psychosis (HP:0000709)1.55078162
167Sleep apnea (HP:0010535)1.54702521
168Neuronal loss in central nervous system (HP:0002529)1.50363401
169Abnormality of ocular smooth pursuit (HP:0000617)1.49750975
170Inappropriate behavior (HP:0000719)1.49697555
171Increased circulating renin level (HP:0000848)1.49451457
172Hypoplastic nipples (HP:0002557)1.48367724
173White forelock (HP:0002211)1.47021308
174Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.45870213
175Lower limb amyotrophy (HP:0007210)1.45799396
176Hip dysplasia (HP:0001385)1.44959154

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.41423188
2NTRK33.32624033
3FRK3.32205052
4EPHA43.25619553
5RIPK42.93246989
6CASK2.84595771
7MAP3K92.68017586
8TAOK32.51153414
9TNIK2.38812237
10MAP2K72.13289662
11MAP3K41.99326499
12PRPF4B1.97191722
13CAMK1D1.91157335
14FES1.89235769
15WNK41.88086902
16MAP3K121.88014898
17CDK191.77574502
18OXSR11.76691202
19NTRK21.73173486
20STK391.66224504
21PNCK1.63107626
22PINK11.55391193
23GRK11.53355507
24ERBB21.47807203
25DAPK21.47092164
26FGR1.44791399
27RIPK11.42588754
28MATK1.36569294
29WNK11.35954117
30PAK61.35426485
31MINK11.32535851
32PHKG11.32490859
33PHKG21.32490859
34UHMK11.30723308
35SIK21.30661647
36NEK61.23704220
37CDK51.22486245
38MAP3K131.20973040
39PKN11.16317232
40BMPR21.15675576
41AKT31.14367132
42SGK4941.13911712
43SGK2231.13911712
44MAPK131.12178604
45CAMK2B1.07495615
46TXK1.07428402
47STK111.07110798
48PLK21.05478091
49PRKD31.05024844
50CAMK2A1.03698018
51CAMK1G1.01904878
52MAPKAPK50.97378047
53ADRBK10.94760092
54CAMK10.94702798
55GRK50.94296815
56MARK10.93770252
57TYRO30.92949895
58TNK20.92819458
59MAP2K40.92385401
60PIK3CA0.92378683
61NTRK10.90080192
62STK380.89987753
63DMPK0.89323115
64SGK20.88211368
65TAOK10.87625141
66ALK0.86831463
67PRKCI0.86427699
68EPHB10.86334771
69SGK10.86044209
70MAP3K20.84941289
71GRK60.84545550
72GRK70.83959225
73MAPKAPK30.83424730
74MAP3K140.82039998
75EPHA20.81761859
76MST40.81653191
77BMPR1B0.79272600
78MARK20.79033189
79SGK30.76137038
80HIPK20.75654305
81RPS6KA20.73410533
82PRKD20.72313050
83FYN0.72259225
84MAPK150.71913073
85BCR0.71070585
86PRKCZ0.70639779
87MAP3K10.70249804
88YES10.68489066
89BLK0.68261582
90KSR20.67921345
91PDPK10.67645239
92BRD40.66120625
93PTK20.65009723
94CLK10.64670433
95PDK10.64192390
96PRKCQ0.62906296
97KIT0.62851924
98CDK120.61954760
99MUSK0.61575575
100PRKCE0.61512937
101CDC42BPA0.61081254
102CAMKK10.58777952
103CDK30.57604600
104PRKCG0.57600907
105CAMK2D0.57129920
106CAMK40.56087408
107HCK0.54223903
108ADRBK20.53894390
109ZAP700.53141842
110ACVR1B0.53042379
111PRKCH0.52520969
112PAK30.51717680
113ROCK20.51566774
114DYRK1A0.50529279
115CSNK1A1L0.50442082
116RPS6KA60.50177128
117MAPK100.49115085
118PDGFRB0.47548485
119BMX0.47328462
120CSNK1G20.47157207
121PTK2B0.46535730
122NME10.46444065
123CDK140.45807687
124DYRK20.45443727
125ABL20.45160289
126PRKD10.45082743
127CSNK1A10.44982070
128CDK150.44666010
129CDK180.44422275
130NUAK10.44252797
131SYK0.43965837
132CAMK2G0.43166118
133IRAK10.43112909
134MAP2K20.42764868
135CDK70.42474207
136PRKACG0.41276113
137AKT10.41131255
138CHUK0.40782742
139MAPK120.40273407
140ICK0.38981289
141PRKAA10.38731826
142PRKACA0.37868035
143IKBKB0.37865786
144RPS6KA30.36647209
145MAP2K10.34888857
146CAMKK20.33448407
147AURKA0.33364951
148MAPK140.32335452

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.08009008
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.20886298
3Glutamatergic synapse_Homo sapiens_hsa047242.19576493
4Morphine addiction_Homo sapiens_hsa050322.17996023
5Olfactory transduction_Homo sapiens_hsa047402.15067460
6GABAergic synapse_Homo sapiens_hsa047272.12081786
7Synaptic vesicle cycle_Homo sapiens_hsa047212.11628874
8Long-term potentiation_Homo sapiens_hsa047202.01024508
9Circadian entrainment_Homo sapiens_hsa047131.99319410
10Salivary secretion_Homo sapiens_hsa049701.94202435
11Amphetamine addiction_Homo sapiens_hsa050311.72471014
12Gastric acid secretion_Homo sapiens_hsa049711.66357744
13Serotonergic synapse_Homo sapiens_hsa047261.65355526
14Long-term depression_Homo sapiens_hsa047301.61566280
15Dopaminergic synapse_Homo sapiens_hsa047281.58682448
16Cholinergic synapse_Homo sapiens_hsa047251.55238403
17Tryptophan metabolism_Homo sapiens_hsa003801.50009240
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.49822032
19Insulin secretion_Homo sapiens_hsa049111.46722045
20Taste transduction_Homo sapiens_hsa047421.44956940
21Linoleic acid metabolism_Homo sapiens_hsa005911.43148892
22Renin secretion_Homo sapiens_hsa049241.42342433
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31264158
24Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28078055
25Calcium signaling pathway_Homo sapiens_hsa040201.28054873
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27186845
27Cocaine addiction_Homo sapiens_hsa050301.26995453
28Oxytocin signaling pathway_Homo sapiens_hsa049211.24904722
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23708597
30Phototransduction_Homo sapiens_hsa047441.20639065
31ErbB signaling pathway_Homo sapiens_hsa040121.20139718
32Dorso-ventral axis formation_Homo sapiens_hsa043201.19005830
33Collecting duct acid secretion_Homo sapiens_hsa049661.18247258
34Ovarian steroidogenesis_Homo sapiens_hsa049131.18027090
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17968485
36GnRH signaling pathway_Homo sapiens_hsa049121.16681335
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15695421
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14988985
39cAMP signaling pathway_Homo sapiens_hsa040241.12576740
40Type I diabetes mellitus_Homo sapiens_hsa049401.10951645
41Axon guidance_Homo sapiens_hsa043601.10740532
42Graft-versus-host disease_Homo sapiens_hsa053321.09098581
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05179709
44Type II diabetes mellitus_Homo sapiens_hsa049301.01793447
45Glycerolipid metabolism_Homo sapiens_hsa005611.00172283
46African trypanosomiasis_Homo sapiens_hsa051430.99902856
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97913902
48Intestinal immune network for IgA production_Homo sapiens_hsa046720.97580665
49Chemokine signaling pathway_Homo sapiens_hsa040620.97147496
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95661084
51MAPK signaling pathway_Homo sapiens_hsa040100.94045618
52Gap junction_Homo sapiens_hsa045400.91911658
53Sphingolipid signaling pathway_Homo sapiens_hsa040710.91385598
54Melanogenesis_Homo sapiens_hsa049160.91310361
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90861152
56Choline metabolism in cancer_Homo sapiens_hsa052310.89813609
57Allograft rejection_Homo sapiens_hsa053300.89588351
58Pancreatic secretion_Homo sapiens_hsa049720.89212927
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.89194528
60Glioma_Homo sapiens_hsa052140.88618663
61Estrogen signaling pathway_Homo sapiens_hsa049150.86387899
62Mineral absorption_Homo sapiens_hsa049780.84688503
63Circadian rhythm_Homo sapiens_hsa047100.84575220
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83623229
65Rheumatoid arthritis_Homo sapiens_hsa053230.83142655
66Notch signaling pathway_Homo sapiens_hsa043300.80911075
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79686228
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79588914
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79519988
70Ras signaling pathway_Homo sapiens_hsa040140.77632691
71Inositol phosphate metabolism_Homo sapiens_hsa005620.77388858
72ABC transporters_Homo sapiens_hsa020100.77023095
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.76779164
74T cell receptor signaling pathway_Homo sapiens_hsa046600.76135131
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74083487
76Sulfur relay system_Homo sapiens_hsa041220.71686642
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70749016
78Insulin resistance_Homo sapiens_hsa049310.70628882
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69544642
80Caffeine metabolism_Homo sapiens_hsa002320.69335645
81Renal cell carcinoma_Homo sapiens_hsa052110.68444711
82Ether lipid metabolism_Homo sapiens_hsa005650.68405602
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67982879
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67569446
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66919819
86Sphingolipid metabolism_Homo sapiens_hsa006000.66483604
87Salmonella infection_Homo sapiens_hsa051320.65667319
88Rap1 signaling pathway_Homo sapiens_hsa040150.65444923
89Fatty acid biosynthesis_Homo sapiens_hsa000610.63926782
90Osteoclast differentiation_Homo sapiens_hsa043800.63821345
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.63442952
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63200517
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62569560
94Vibrio cholerae infection_Homo sapiens_hsa051100.60754901
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60493529
96VEGF signaling pathway_Homo sapiens_hsa043700.60235146
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60047894
98B cell receptor signaling pathway_Homo sapiens_hsa046620.59724028
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59166698
100Bile secretion_Homo sapiens_hsa049760.59106842
101Autoimmune thyroid disease_Homo sapiens_hsa053200.58970448
102Wnt signaling pathway_Homo sapiens_hsa043100.58673315
103* Endocytosis_Homo sapiens_hsa041440.58078432
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.57613462
105Tuberculosis_Homo sapiens_hsa051520.55495355
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53534015
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51645871
108Arachidonic acid metabolism_Homo sapiens_hsa005900.51043131
109Thyroid hormone synthesis_Homo sapiens_hsa049180.50877010
110Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49568288
111Basal transcription factors_Homo sapiens_hsa030220.49339445
112Prolactin signaling pathway_Homo sapiens_hsa049170.49086841
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.48827850
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.48570713
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48281105
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47857300
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.47317010
118Hippo signaling pathway_Homo sapiens_hsa043900.46635342
119Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45962012
120Dilated cardiomyopathy_Homo sapiens_hsa054140.45895242
121Vitamin digestion and absorption_Homo sapiens_hsa049770.45877177
122Histidine metabolism_Homo sapiens_hsa003400.45819846
123Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45532166
124Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44239246
125Platelet activation_Homo sapiens_hsa046110.44228986
126NF-kappa B signaling pathway_Homo sapiens_hsa040640.44126119
127Nitrogen metabolism_Homo sapiens_hsa009100.43682644
128Cardiac muscle contraction_Homo sapiens_hsa042600.43462364
129TNF signaling pathway_Homo sapiens_hsa046680.43129866
130Chemical carcinogenesis_Homo sapiens_hsa052040.42828526
131Retinol metabolism_Homo sapiens_hsa008300.40031805
132Fat digestion and absorption_Homo sapiens_hsa049750.38931093

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