WIPF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.87203333
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.49366886
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.49366886
4antigen processing and presentation of endogenous antigen (GO:0019883)5.30650009
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.92744738
6negative regulation of cell killing (GO:0031342)4.92744738
7regulation of B cell receptor signaling pathway (GO:0050855)4.78157864
8negative thymic T cell selection (GO:0045060)4.78053999
9negative T cell selection (GO:0043383)4.77405718
10leukocyte aggregation (GO:0070486)4.73601276
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.64706736
12regulation of gamma-delta T cell differentiation (GO:0045586)4.62957973
13positive thymic T cell selection (GO:0045059)4.58138071
14detection of other organism (GO:0098543)4.30792781
15regulation of gamma-delta T cell activation (GO:0046643)4.29570287
16interferon-gamma production (GO:0032609)4.29087601
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.24638208
18macrophage activation involved in immune response (GO:0002281)4.18488867
19detection of bacterium (GO:0016045)4.09483713
20thymic T cell selection (GO:0045061)4.07916773
21B cell receptor signaling pathway (GO:0050853)4.05498363
22T cell migration (GO:0072678)4.02067676
23response to interleukin-15 (GO:0070672)3.98943960
24negative regulation of lymphocyte mediated immunity (GO:0002707)3.98361627
25negative regulation of T cell mediated immunity (GO:0002710)3.91087681
26positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.90796379
27tolerance induction (GO:0002507)3.87983068
28neutrophil activation involved in immune response (GO:0002283)3.81393985
29response to peptidoglycan (GO:0032494)3.81084598
30regulation of B cell differentiation (GO:0045577)3.81064568
31T cell selection (GO:0045058)3.76760461
32detection of external biotic stimulus (GO:0098581)3.75686289
33detection of molecule of bacterial origin (GO:0032490)3.72940605
34positive T cell selection (GO:0043368)3.71227810
35regulation of T cell tolerance induction (GO:0002664)3.68009849
36regulation of interleukin-12 biosynthetic process (GO:0045075)3.66935205
37cellular response to interleukin-15 (GO:0071350)3.65862316
38activated T cell proliferation (GO:0050798)3.64021798
39positive regulation of B cell differentiation (GO:0045579)3.62725989
40cellular extravasation (GO:0045123)3.59835014
41positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.59593844
42response to host immune response (GO:0052572)3.57767788
43response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.57767788
44microglial cell activation (GO:0001774)3.55986026
45negative regulation of leukocyte mediated immunity (GO:0002704)3.55260041
46modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.54108248
47modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.54108248
48positive regulation by organism of defense response of other organism involved in symbiotic interact3.54108248
49modulation by symbiont of host immune response (GO:0052553)3.54108248
50positive regulation by symbiont of host defense response (GO:0052509)3.54108248
51modulation by symbiont of host defense response (GO:0052031)3.54108248
52T cell costimulation (GO:0031295)3.49615126
53Arp2/3 complex-mediated actin nucleation (GO:0034314)3.43675152
54lymphocyte costimulation (GO:0031294)3.43511554
55regulation of interferon-beta biosynthetic process (GO:0045357)3.41163316
56negative regulation of erythrocyte differentiation (GO:0045647)3.38683738
57regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.37833709
58antigen processing and presentation via MHC class Ib (GO:0002475)3.37004819
59regulation of alpha-beta T cell proliferation (GO:0046640)3.36756979
60positive regulation of granulocyte differentiation (GO:0030854)3.33992533
61antigen receptor-mediated signaling pathway (GO:0050851)3.33210667
62neutrophil activation (GO:0042119)3.32400865
63response to host (GO:0075136)3.32075477
64response to host defenses (GO:0052200)3.32075477
65response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.32075477
66detection of biotic stimulus (GO:0009595)3.28535301
67respiratory burst (GO:0045730)3.27303280
68negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.23330128
69mast cell activation (GO:0045576)3.22822376
70positive regulation of interleukin-2 production (GO:0032743)3.22417192
71germinal center formation (GO:0002467)3.21571900
72immunoglobulin mediated immune response (GO:0016064)3.20793253
73negative regulation of phagocytosis (GO:0050765)3.20319815
74T cell receptor signaling pathway (GO:0050852)3.17888321
75positive regulation of isotype switching (GO:0045830)3.17814196
76leukocyte cell-cell adhesion (GO:0007159)3.16875624
77JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.16388978
78macrophage activation (GO:0042116)3.15241356
79regulation of isotype switching to IgG isotypes (GO:0048302)3.14544499
80regulation of mast cell degranulation (GO:0043304)3.13067669
81positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.12876007
82granulocyte activation (GO:0036230)3.09541062
83regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.09490425
84myeloid dendritic cell activation (GO:0001773)3.09141883
85B cell mediated immunity (GO:0019724)3.05990717
86positive regulation of antigen processing and presentation (GO:0002579)3.05660079
87regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.05465213
88negative regulation of interleukin-12 production (GO:0032695)3.01490873
89leukocyte degranulation (GO:0043299)3.00582155
90regulation of T cell mediated cytotoxicity (GO:0001914)3.00561008
91defense response to protozoan (GO:0042832)2.98939251
92negative regulation of T-helper cell differentiation (GO:0045623)2.97706532
93negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.97706532
94regulation of interleukin-2 biosynthetic process (GO:0045076)2.97669919
95regulation of tolerance induction (GO:0002643)2.96961905
96positive regulation of alpha-beta T cell proliferation (GO:0046641)2.95013862
97positive regulation of tolerance induction (GO:0002645)2.93366210
98leukocyte migration involved in inflammatory response (GO:0002523)2.93151509
99T cell proliferation (GO:0042098)2.93059763
100myeloid dendritic cell differentiation (GO:0043011)2.91951589
101T cell homeostasis (GO:0043029)2.91872346
102mature B cell differentiation (GO:0002335)2.91215605
103negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.90741964
104regulation of dendritic cell antigen processing and presentation (GO:0002604)2.89941497
105interferon-gamma-mediated signaling pathway (GO:0060333)2.89390148
106positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.88334852
107regulation of mast cell activation involved in immune response (GO:0033006)2.87766904
108regulation of T cell receptor signaling pathway (GO:0050856)2.86788657
109regulation of mast cell activation (GO:0033003)2.86556552
110neutrophil mediated immunity (GO:0002446)2.86237150
111dendritic cell chemotaxis (GO:0002407)2.85511804
112natural killer cell activation (GO:0030101)2.84037386
113response to type I interferon (GO:0034340)2.83866705
114NIK/NF-kappaB signaling (GO:0038061)2.83801738
115positive regulation of macrophage differentiation (GO:0045651)2.83669550
116myeloid cell activation involved in immune response (GO:0002275)2.81832324
117regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.81462261
118regulation of natural killer cell mediated immunity (GO:0002715)2.81462261
119* immune response-activating cell surface receptor signaling pathway (GO:0002429)2.81252822
120negative regulation of B cell proliferation (GO:0030889)2.80996801
121regulation of interferon-alpha production (GO:0032647)2.79985269
122positive regulation of interferon-alpha production (GO:0032727)2.78185595
123type I interferon signaling pathway (GO:0060337)2.77884116
124cellular response to type I interferon (GO:0071357)2.77884116
125response to protozoan (GO:0001562)2.76334037
126response to muramyl dipeptide (GO:0032495)2.76073575
127regulation of regulatory T cell differentiation (GO:0045589)2.74126802
128lymphocyte homeostasis (GO:0002260)2.73206983
129response to laminar fluid shear stress (GO:0034616)2.72309932
130positive regulation of immunoglobulin mediated immune response (GO:0002891)2.71697310
131positive regulation of B cell mediated immunity (GO:0002714)2.71697310
132positive regulation of mast cell activation (GO:0033005)2.70791439
133regulation of antigen processing and presentation (GO:0002577)2.70093205
134cellular response to zinc ion (GO:0071294)2.69185009
135pinocytosis (GO:0006907)2.68756714
136regulation of type I interferon-mediated signaling pathway (GO:0060338)2.68461379
137negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.68000952
138positive regulation of DNA recombination (GO:0045911)2.67932328

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.17939341
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.75238800
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.64583027
4* IRF8_21731497_ChIP-ChIP_J774_Mouse4.10430673
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.98787059
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.59491105
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.50134871
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.27386638
9* IRF8_27001747_Chip-Seq_BMDM_Mouse3.20903198
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.11703360
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.10264939
12MYC_22102868_ChIP-Seq_BL_Human3.08639968
13* RUNX_20019798_ChIP-Seq_JUKART_Human3.01692117
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.96330206
15* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.93000207
16VDR_21846776_ChIP-Seq_THP-1_Human2.89594662
17* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.83704089
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.83160640
19* MYB_26560356_Chip-Seq_TH2_Human2.80274640
20* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.77129010
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.76756150
22MAF_26560356_Chip-Seq_TH1_Human2.71988801
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.71627182
24E2F7_22180533_ChIP-Seq_HELA_Human2.58668046
25SCL_19346495_ChIP-Seq_HPC-7_Human2.53659557
26MYB_26560356_Chip-Seq_TH1_Human2.40460379
27VDR_24763502_ChIP-Seq_THP-1_Human2.34132480
28UTX_26944678_Chip-Seq_JUKART_Human2.29464671
29* SPI1_23547873_ChIP-Seq_NB4_Human2.25451471
30* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.20518105
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.16276633
32RUNX1_22412390_ChIP-Seq_EML_Mouse2.08871933
33TCF7_22412390_ChIP-Seq_EML_Mouse2.07701217
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.03211929
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.02558870
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.92307553
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.91004570
38SPI1_23127762_ChIP-Seq_K562_Human1.90785160
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90297641
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.89360345
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.87375461
42KDM2B_26808549_Chip-Seq_DND41_Human1.80732023
43MAF_26560356_Chip-Seq_TH2_Human1.77337340
44GATA3_27048872_Chip-Seq_THYMUS_Human1.71976367
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.71719192
46* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61830624
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.59820254
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.59508963
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.58393159
50* PU_27001747_Chip-Seq_BMDM_Mouse1.57757462
51GATA1_22025678_ChIP-Seq_K562_Human1.48949866
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.45039658
53NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.44490488
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43990864
55SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39423532
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34877775
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34450457
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.28260072
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26846989
60VDR_24787735_ChIP-Seq_THP-1_Human1.26353726
61PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26039679
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25500192
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.23676260
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22736347
65CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20917123
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17692346
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17136987
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12922527
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11539434
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10971361
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.10727920
72* GATA3_26560356_Chip-Seq_TH2_Human1.10322461
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09065340
74NCOR1_26117541_ChIP-Seq_K562_Human0.99390086
75ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99102478
76IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98859172
77PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98356203
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97776957
79GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97010100
80GATA2_21666600_ChIP-Seq_HMVEC_Human0.96376730
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95142307
82RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94507310
83PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94027678
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93319550
85CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91482082
86GATA1_19941826_ChIP-Seq_K562_Human0.90682853
87* GATA1_19941827_ChIP-Seq_MEL_Mouse0.90585706
88CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90469696
89* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89572395
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89095812
91THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88985816
92* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88604592
93ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86250418
94KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83239119
95BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.82433044
96PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82060251
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.81759577
98FOXO3_23340844_ChIP-Seq_DLD1_Human0.81581897
99* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80429115
100PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79762257
101* GATA2_19941826_ChIP-Seq_K562_Human0.79621755
102BCL6_27268052_Chip-Seq_Bcells_Human0.78422672
103SMRT_27268052_Chip-Seq_Bcells_Human0.77997933
104SMAD_19615063_ChIP-ChIP_OVARY_Human0.75756824
105TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75744099
106CIITA_25753668_ChIP-Seq_RAJI_Human0.74765150
107TFEB_21752829_ChIP-Seq_HELA_Human0.73997205
108LXR_22292898_ChIP-Seq_THP-1_Human0.73984308
109CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73599576
110* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72074916
111SPI1_20517297_ChIP-Seq_HL60_Human0.71939808
112GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70967080

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.99813208
2MP0005671_abnormal_response_to3.46284547
3MP0005387_immune_system_phenotype3.33138043
4MP0001790_abnormal_immune_system3.33138043
5MP0003303_peritoneal_inflammation3.32695216
6MP0000685_abnormal_immune_system3.28203295
7* MP0001800_abnormal_humoral_immune3.19428356
8MP0005000_abnormal_immune_tolerance3.06137315
9MP0003436_decreased_susceptibility_to2.99160965
10MP0003763_abnormal_thymus_physiology2.92373710
11* MP0002452_abnormal_antigen_presenting2.82734229
12MP0003300_gastrointestinal_ulcer2.70843083
13* MP0002723_abnormal_immune_serum2.70720744
14* MP0002420_abnormal_adaptive_immunity2.68815660
15* MP0001819_abnormal_immune_cell2.65756352
16MP0006082_CNS_inflammation2.61802378
17MP0009785_altered_susceptibility_to2.60611084
18MP0005025_abnormal_response_to2.58693903
19MP0002419_abnormal_innate_immunity2.50685289
20MP0002148_abnormal_hypersensitivity_rea2.46290861
21* MP0002398_abnormal_bone_marrow2.36215215
22MP0002405_respiratory_system_inflammati2.31788224
23MP0002396_abnormal_hematopoietic_system2.21672268
24* MP0000716_abnormal_immune_system2.21550616
25MP0002166_altered_tumor_susceptibility2.21232457
26MP0003724_increased_susceptibility_to2.16118441
27MP0009333_abnormal_splenocyte_physiolog2.16034539
28MP0004510_myositis2.06502895
29MP0001873_stomach_inflammation2.04952891
30MP0000689_abnormal_spleen_morphology1.98284778
31MP0009278_abnormal_bone_marrow1.95343616
32MP0005464_abnormal_platelet_physiology1.92635933
33* MP0002722_abnormal_immune_system1.89741368
34MP0010155_abnormal_intestine_physiology1.85056671
35* MP0002429_abnormal_blood_cell1.81755280
36MP0000465_gastrointestinal_hemorrhage1.80234791
37MP0002933_joint_inflammation1.75732256
38MP0002006_tumorigenesis1.73099266
39MP0008260_abnormal_autophagy1.71826601
40MP0004808_abnormal_hematopoietic_stem1.71022742
41MP0004947_skin_inflammation1.70775673
42MP0001845_abnormal_inflammatory_respons1.69673001
43* MP0000703_abnormal_thymus_morphology1.68746902
44MP0005058_abnormal_lysosome_morphology1.64795848
45MP0001533_abnormal_skeleton_physiology1.62644571
46MP0003448_altered_tumor_morphology1.55749294
47MP0005310_abnormal_salivary_gland1.55619363
48MP0001853_heart_inflammation1.52630037
49MP0005397_hematopoietic_system_phenotyp1.47957798
50MP0001545_abnormal_hematopoietic_system1.47957798
51MP0003866_abnormal_defecation1.46731767
52MP0005451_abnormal_body_composition1.36278863
53MP0001851_eye_inflammation1.29336564
54MP0000858_altered_metastatic_potential1.23690567
55MP0004883_abnormal_blood_vessel1.23666552
56MP0002998_abnormal_bone_remodeling1.16055092
57MP0008469_abnormal_protein_level1.15272520
58MP0002138_abnormal_hepatobiliary_system1.11769318
59MP0000490_abnormal_crypts_of1.11040149
60MP0003172_abnormal_lysosome_physiology1.10267901
61MP0000343_altered_response_to1.10134292
62MP0008004_abnormal_stomach_pH1.04608787
63MP0000920_abnormal_myelination1.02962478
64MP0005076_abnormal_cell_differentiation1.00358938
65MP0010352_gastrointestinal_tract_polyps0.99264156
66MP0005174_abnormal_tail_pigmentation0.99218185
67MP0000569_abnormal_digit_pigmentation0.98875467
68MP0003091_abnormal_cell_migration0.96878349
69MP0005023_abnormal_wound_healing0.92306132
70MP0005164_abnormal_response_to0.90093635
71MP0003828_pulmonary_edema0.89564637
72MP0003656_abnormal_erythrocyte_physiolo0.86979959
73MP0003566_abnormal_cell_adhesion0.86935688
74MP0003279_aneurysm0.85286670
75MP0008057_abnormal_DNA_replication0.84246282
76MP0002019_abnormal_tumor_incidence0.83515830
77MP0005390_skeleton_phenotype0.82361618
78MP0008438_abnormal_cutaneous_collagen0.80366811
79MP0004130_abnormal_muscle_cell0.77801556
80MP0003045_fibrosis0.77559643
81MP0000733_abnormal_muscle_development0.76334139
82MP0003183_abnormal_peptide_metabolism0.76277631
83MP0003453_abnormal_keratinocyte_physiol0.75556042
84MP0003191_abnormal_cellular_cholesterol0.74521949
85MP0010307_abnormal_tumor_latency0.74316957
86MP0000249_abnormal_blood_vessel0.73637033
87MP0009764_decreased_sensitivity_to0.70505793
88MP0003795_abnormal_bone_structure0.68078492
89MP0005166_decreased_susceptibility_to0.67074946
90MP0003075_altered_response_to0.67039059
91MP0001958_emphysema0.66793772
92MP0001663_abnormal_digestive_system0.66493232
93MP0000767_abnormal_smooth_muscle0.66099245
94MP0009763_increased_sensitivity_to0.65279841
95MP0009765_abnormal_xenobiotic_induced0.64211874
96MP0008874_decreased_physiological_sensi0.64150887
97MP0009840_abnormal_foam_cell0.63098921
98MP0006054_spinal_hemorrhage0.62819339
99MP0002009_preneoplasia0.61703583
100MP0003690_abnormal_glial_cell0.60395634
101MP0000604_amyloidosis0.59559792
102MP0001348_abnormal_lacrimal_gland0.56883790
103MP0002277_abnormal_respiratory_mucosa0.55271825
104MP0004185_abnormal_adipocyte_glucose0.54005353
105MP0004381_abnormal_hair_follicle0.53159065
106MP0005075_abnormal_melanosome_morpholog0.52223021
107MP0001986_abnormal_taste_sensitivity0.51433471
108MP0003221_abnormal_cardiomyocyte_apopto0.50940246
109MP0002132_abnormal_respiratory_system0.50661440
110MP0000015_abnormal_ear_pigmentation0.50378030
111MP0002136_abnormal_kidney_physiology0.49483990
112MP0001243_abnormal_dermal_layer0.48351946
113MP0005388_respiratory_system_phenotype0.47118567
114MP0002133_abnormal_respiratory_system0.47118567
115MP0005381_digestive/alimentary_phenotyp0.46359936
116MP0009115_abnormal_fat_cell0.45537397
117MP0004484_altered_response_of0.44828716

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.28512239
2Recurrent abscess formation (HP:0002722)5.10607267
3Myositis (HP:0100614)4.46867303
4Recurrent bacterial skin infections (HP:0005406)4.44747507
5Chronic otitis media (HP:0000389)4.32914986
6Recurrent viral infections (HP:0004429)4.24697933
7Recurrent fungal infections (HP:0002841)4.21322530
8Elevated erythrocyte sedimentation rate (HP:0003565)4.19891254
9Cellulitis (HP:0100658)4.00048526
10Recurrent bronchitis (HP:0002837)3.79363959
11IgM deficiency (HP:0002850)3.76752892
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.73675879
13Stomatitis (HP:0010280)3.61003521
14Agammaglobulinemia (HP:0004432)3.52589037
15Orchitis (HP:0100796)3.51030549
16* Meningitis (HP:0001287)3.49301288
17Abnormality of macrophages (HP:0004311)3.46971916
18* T lymphocytopenia (HP:0005403)3.46738079
19Panhypogammaglobulinemia (HP:0003139)3.45514278
20* Abnormality of T cell number (HP:0011839)3.42826628
21Recurrent skin infections (HP:0001581)3.42407322
22Nasal polyposis (HP:0100582)3.36910618
23Pustule (HP:0200039)3.25950764
24Optic neuritis (HP:0100653)3.25411331
25Retrobulbar optic neuritis (HP:0100654)3.25411331
26Mediastinal lymphadenopathy (HP:0100721)3.25247932
27Abnormality of the nasal mucosa (HP:0000433)3.18654828
28Chronic mucocutaneous candidiasis (HP:0002728)3.16378175
29Recurrent cutaneous fungal infections (HP:0011370)3.16378175
30* Vasculitis (HP:0002633)3.12032880
31* Obstructive lung disease (HP:0006536)3.11359751
32* Chronic obstructive pulmonary disease (HP:0006510)3.11359751
33Recurrent gram-negative bacterial infections (HP:0005420)3.10015464
34Autoimmune thrombocytopenia (HP:0001973)3.08520076
35* Abnormality of T cells (HP:0002843)3.07420787
36Increased IgM level (HP:0003496)2.94550150
37Lymphopenia (HP:0001888)2.89194783
38Leukocytosis (HP:0001974)2.89082034
39Autoimmune hemolytic anemia (HP:0001890)2.88956355
40Gastrointestinal stroma tumor (HP:0100723)2.86953057
41Colitis (HP:0002583)2.86313400
42* Gingival bleeding (HP:0000225)2.84784163
43Abnormality of cells of the lymphoid lineage (HP:0012140)2.80413359
44Abnormality of T cell physiology (HP:0011840)2.77459929
45Eosinophilia (HP:0001880)2.76240430
46* Inflammation of the large intestine (HP:0002037)2.74128025
47Verrucae (HP:0200043)2.72789581
48Papilloma (HP:0012740)2.72789581
49Purpura (HP:0000979)2.70740567
50* Urticaria (HP:0001025)2.70111804
51Thyroiditis (HP:0100646)2.69984076
52Severe combined immunodeficiency (HP:0004430)2.69532709
53Pulmonary infiltrates (HP:0002113)2.65495897
54* Gastrointestinal inflammation (HP:0004386)2.63334732
55Combined immunodeficiency (HP:0005387)2.61477226
56Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.60928130
57Hemoptysis (HP:0002105)2.59503345
58Emphysema (HP:0002097)2.57076792
59Abnormality of the fingertips (HP:0001211)2.56414380
60Abnormality of B cell number (HP:0010975)2.55142700
61B lymphocytopenia (HP:0010976)2.55142700
62Hematochezia (HP:0002573)2.54616846
63Vacuolated lymphocytes (HP:0001922)2.53404912
64Abnormality of eosinophils (HP:0001879)2.53196655
65Arterial thrombosis (HP:0004420)2.52551887
66Osteomyelitis (HP:0002754)2.51644070
67Increased IgE level (HP:0003212)2.50662564
68IgG deficiency (HP:0004315)2.50363097
69Thrombocytosis (HP:0001894)2.49944149
70Gingivitis (HP:0000230)2.49735749
71Increased cerebral lipofuscin (HP:0011813)2.47275658
72Prolonged bleeding time (HP:0003010)2.45797475
73* Spontaneous hematomas (HP:0007420)2.42605932
74Peritonitis (HP:0002586)2.40209641
75Osteolytic defects of the hand bones (HP:0009699)2.39497152
76Osteolytic defects of the phalanges of the hand (HP:0009771)2.39497152
77Hypochromic anemia (HP:0001931)2.38495574
78Granulocytopenia (HP:0001913)2.35723547
79Anorexia (HP:0002039)2.35270931
80Recurrent pneumonia (HP:0006532)2.34946080
81Recurrent sinusitis (HP:0011108)2.34359332
82Interstitial pulmonary disease (HP:0006530)2.34093799
83Episodic fever (HP:0001954)2.33195244
84Papilledema (HP:0001085)2.32898128
85Petechiae (HP:0000967)2.32522538
86Increased density of long bones (HP:0006392)2.32472713
87Recurrent lower respiratory tract infections (HP:0002783)2.31513309
88Chronic diarrhea (HP:0002028)2.30228405
89IgA deficiency (HP:0002720)2.28229049
90Increased neuronal autofluorescent lipopigment (HP:0002074)2.25167324
91Gangrene (HP:0100758)2.24286671
92Abnormality of the pleura (HP:0002103)2.24126464
93Viral hepatitis (HP:0006562)2.23425982
94Chronic sinusitis (HP:0011109)2.23046048
95Restrictive lung disease (HP:0002091)2.23036673
96Keratoconjunctivitis sicca (HP:0001097)2.21038380
97Slow saccadic eye movements (HP:0000514)2.20142204
98Periodontitis (HP:0000704)2.19996579
99Abnormal platelet volume (HP:0011876)2.19424605
100Hypochromic microcytic anemia (HP:0004840)2.16670942
101Abnormality of the peritoneum (HP:0002585)2.15801218
102Joint swelling (HP:0001386)2.13531794
103Dysostosis multiplex (HP:0000943)2.12979478
104Spondylolisthesis (HP:0003302)2.11953787
105Increased mean platelet volume (HP:0011877)2.11875981
106Gastrointestinal infarctions (HP:0005244)2.10827503
107Fatigue (HP:0012378)2.09955401
108Menorrhagia (HP:0000132)2.08219561
109Hypergammaglobulinemia (HP:0010702)2.06481092
110Acute hepatic failure (HP:0006554)2.03394248
111* Encephalitis (HP:0002383)2.01647378
112Disinhibition (HP:0000734)1.99516127
113* Skin ulcer (HP:0200042)1.98389416
114Amaurosis fugax (HP:0100576)1.96884869
115* Epistaxis (HP:0000421)1.96713555
116Keratoconjunctivitis (HP:0001096)1.96178347
117Abnormality of the endocardium (HP:0004306)1.93705681
118* Chest pain (HP:0100749)1.93290373
119Vertigo (HP:0002321)1.90855979
120Abnormality of the prostate (HP:0008775)1.90688352
121Skin rash (HP:0000988)1.89882714
122* Pulmonary embolism (HP:0002204)1.89504674
123Myocardial infarction (HP:0001658)1.88802100
124Arthralgia (HP:0002829)1.87759393
125* Lymphoma (HP:0002665)1.87250607
126* Sepsis (HP:0100806)1.87219460

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.30106796
2TXK3.49517762
3BLK2.77736114
4PRPF4B2.66023798
5STK102.55463583
6JAK32.52594073
7EPHB12.49761946
8TYK22.31325513
9ITK2.26007491
10ZAP702.18487732
11MAP3K142.16551172
12IRAK42.02331541
13CSK2.00362775
14ERN11.96765839
15BTK1.96620877
16GRK61.90697943
17CSF1R1.83111136
18KIT1.83073038
19IKBKE1.82898413
20JAK11.82212219
21TBK11.82136484
22MAP3K101.68706552
23TGFBR21.66601474
24TEC1.65558967
25EEF2K1.63984054
26LRRK21.60607278
27CLK11.59341648
28SYK1.58879566
29LCK1.58221125
30HCK1.57127895
31IKBKB1.56901313
32MAP3K131.55064236
33TRIB31.51065976
34FES1.50300614
35FGFR41.48593019
36FGFR31.33209689
37SIK31.26809229
38MAP3K31.25156829
39CDK121.16598979
40TESK21.16115946
41BMPR21.15264041
42RIPK41.14497677
43PKN21.11928415
44PIM11.11894943
45NLK1.09918091
46MST41.08914134
47TAOK11.08810575
48MAP3K11.07129644
49LYN1.05633352
50MAP3K111.04154053
51PIK3CG1.02572227
52SIK21.00015627
53MARK30.99170410
54FGR0.96746919
55KDR0.95146591
56IRAK30.90875760
57MAP2K30.90798706
58TRPM70.90662535
59YES10.88538263
60MATK0.88409221
61KSR20.85745397
62PRKCH0.85363416
63JAK20.85141587
64CAMKK20.84755695
65TTN0.81815618
66CHUK0.81730916
67NME20.81413260
68RPS6KA40.80112829
69* PRKCQ0.76931032
70MAPK120.75927960
71PTK60.74207734
72MAPK70.74030456
73STK40.73827525
74TAOK30.73353023
75ALK0.70943556
76EPHA30.69948066
77PDGFRB0.68875349
78DMPK0.68715403
79TAOK20.68270449
80HIPK20.67315342
81CDC42BPA0.67025825
82CAMKK10.66246413
83CDK40.64067742
84IRAK20.63937908
85TNK20.63666655
86MAP3K60.63517787
87SMG10.62307380
88PTK2B0.61908830
89CDK60.61867059
90PDPK10.60996341
91PIM20.59261849
92NEK90.57822708
93PRKD20.56504798
94MAP3K50.54570678
95CAMK1D0.53892029
96MAP3K70.53646477
97BMX0.52931841
98PDK10.52176301
99GRK70.51809153
100RET0.50996133
101ABL10.50598950
102SGK30.50273125
103CAMK1G0.50228290
104MAP3K20.49954381
105CDK190.49143332
106EGFR0.48725962
107MAPKAPK20.47757997
108CDK90.46961292
109FYN0.46143304
110MAPK110.44328615
111MAP3K80.43177915
112SGK20.42446987
113PRKD10.41156432
114INSR0.40338877
115MELK0.39809633
116NEK20.39193198
117RAF10.38836220
118STK110.36097033
119RPS6KL10.34662654
120RPS6KC10.34662654
121STK240.33907345
122DYRK1B0.33362805
123RPS6KA50.31954179
124MAPK40.31937613
125RPS6KA60.31885469
126MARK20.30687946
127MAP2K60.29832186
128PKN10.29567257
129STK30.29221851
130IRAK10.29079146
131PAK40.28493577
132WNK10.28273923
133IGF1R0.27401067
134BRD40.23622876
135RIPK10.23354789
136PRKCD0.21971903

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.61540151
2B cell receptor signaling pathway_Homo sapiens_hsa046622.69805817
3Leishmaniasis_Homo sapiens_hsa051402.59538357
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.42654051
5Osteoclast differentiation_Homo sapiens_hsa043802.42313447
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.40311555
7T cell receptor signaling pathway_Homo sapiens_hsa046602.38464507
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.35886490
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.26943348
10Measles_Homo sapiens_hsa051622.22504811
11Allograft rejection_Homo sapiens_hsa053302.08215810
12Antigen processing and presentation_Homo sapiens_hsa046122.06564022
13Graft-versus-host disease_Homo sapiens_hsa053322.04350478
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.98875156
15Hematopoietic cell lineage_Homo sapiens_hsa046401.95659178
16Staphylococcus aureus infection_Homo sapiens_hsa051501.74732159
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.67455315
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.66279702
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.66223316
20Viral myocarditis_Homo sapiens_hsa054161.65440517
21Chemokine signaling pathway_Homo sapiens_hsa040621.62322968
22Toxoplasmosis_Homo sapiens_hsa051451.62130614
23Shigellosis_Homo sapiens_hsa051311.61349253
24Malaria_Homo sapiens_hsa051441.61088779
25Autoimmune thyroid disease_Homo sapiens_hsa053201.58550545
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.56093620
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.42197685
28Tuberculosis_Homo sapiens_hsa051521.41646770
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40697248
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39720401
31Asthma_Homo sapiens_hsa053101.39671695
32Herpes simplex infection_Homo sapiens_hsa051681.37696184
33Chronic myeloid leukemia_Homo sapiens_hsa052201.36870887
34Pertussis_Homo sapiens_hsa051331.34069455
35Acute myeloid leukemia_Homo sapiens_hsa052211.32920344
36Hepatitis B_Homo sapiens_hsa051611.30385201
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.28399713
38Apoptosis_Homo sapiens_hsa042101.28120615
39Platelet activation_Homo sapiens_hsa046111.26209221
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23038314
41Pancreatic cancer_Homo sapiens_hsa052121.21453299
42Influenza A_Homo sapiens_hsa051641.19729786
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19137200
44TNF signaling pathway_Homo sapiens_hsa046681.17603783
45Salmonella infection_Homo sapiens_hsa051321.17498630
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13028294
47Other glycan degradation_Homo sapiens_hsa005111.09083678
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.07736200
49Legionellosis_Homo sapiens_hsa051341.06564260
50Lysosome_Homo sapiens_hsa041421.01894900
51Glycosaminoglycan degradation_Homo sapiens_hsa005310.97885276
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93690805
53Renal cell carcinoma_Homo sapiens_hsa052110.87015443
54Epstein-Barr virus infection_Homo sapiens_hsa051690.86934799
55Hepatitis C_Homo sapiens_hsa051600.86121842
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85240489
57HTLV-I infection_Homo sapiens_hsa051660.83957320
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83909412
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.83566993
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81119963
61Rheumatoid arthritis_Homo sapiens_hsa053230.80922418
62VEGF signaling pathway_Homo sapiens_hsa043700.79432993
63Small cell lung cancer_Homo sapiens_hsa052220.79140736
64Non-small cell lung cancer_Homo sapiens_hsa052230.78973146
65Viral carcinogenesis_Homo sapiens_hsa052030.78967227
66Colorectal cancer_Homo sapiens_hsa052100.76001132
67* Endocytosis_Homo sapiens_hsa041440.73973492
68Prolactin signaling pathway_Homo sapiens_hsa049170.72968783
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72941591
70Notch signaling pathway_Homo sapiens_hsa043300.72392767
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72272109
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.70474033
73Endometrial cancer_Homo sapiens_hsa052130.67196139
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67187745
75MicroRNAs in cancer_Homo sapiens_hsa052060.64395304
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64051407
77Proteoglycans in cancer_Homo sapiens_hsa052050.60000272
78Phagosome_Homo sapiens_hsa041450.59712192
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58695462
80Focal adhesion_Homo sapiens_hsa045100.57464458
81Prostate cancer_Homo sapiens_hsa052150.55773361
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55142256
83Type I diabetes mellitus_Homo sapiens_hsa049400.52022801
84GnRH signaling pathway_Homo sapiens_hsa049120.51881755
85Amoebiasis_Homo sapiens_hsa051460.51174315
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50425049
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49585792
88MAPK signaling pathway_Homo sapiens_hsa040100.48956761
89Ribosome_Homo sapiens_hsa030100.46970308
90FoxO signaling pathway_Homo sapiens_hsa040680.46524717
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.46114341
92Pathways in cancer_Homo sapiens_hsa052000.46018858
93Non-homologous end-joining_Homo sapiens_hsa034500.44393560
94Dorso-ventral axis formation_Homo sapiens_hsa043200.44350930
95African trypanosomiasis_Homo sapiens_hsa051430.43982735
96Rap1 signaling pathway_Homo sapiens_hsa040150.41892541
97HIF-1 signaling pathway_Homo sapiens_hsa040660.41622734
98Glioma_Homo sapiens_hsa052140.41540311
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40647734
100ErbB signaling pathway_Homo sapiens_hsa040120.40008540
101Adherens junction_Homo sapiens_hsa045200.39308498
102p53 signaling pathway_Homo sapiens_hsa041150.36939342
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35904727
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.33681688
105Ras signaling pathway_Homo sapiens_hsa040140.33366444
106Base excision repair_Homo sapiens_hsa034100.33286680
107Type II diabetes mellitus_Homo sapiens_hsa049300.32913313
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31773654
109Choline metabolism in cancer_Homo sapiens_hsa052310.30878552
110Insulin resistance_Homo sapiens_hsa049310.30598850
111Inositol phosphate metabolism_Homo sapiens_hsa005620.29699878
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29616537
113mTOR signaling pathway_Homo sapiens_hsa041500.28940989

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