WHAMMP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)6.05206299
2protein neddylation (GO:0045116)5.75661854
3neutrophil activation involved in immune response (GO:0002283)4.64581641
4regulation of platelet aggregation (GO:0090330)4.21312134
5purinergic nucleotide receptor signaling pathway (GO:0035590)4.00941420
6regulation of platelet activation (GO:0010543)3.96652260
7negative regulation of calcium ion transport into cytosol (GO:0010523)3.83561679
8negative regulation of heart rate (GO:0010459)3.74705226
9regulation of memory T cell differentiation (GO:0043380)3.71672580
10blood coagulation, intrinsic pathway (GO:0007597)3.67540356
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.59510453
12amine catabolic process (GO:0009310)3.57057899
13cellular biogenic amine catabolic process (GO:0042402)3.57057899
14positive regulation of cAMP-mediated signaling (GO:0043950)3.56662874
15leukocyte migration involved in inflammatory response (GO:0002523)3.54740954
16negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.51844000
17positive regulation of mast cell activation (GO:0033005)3.44972800
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.44317636
19dopamine transport (GO:0015872)3.40122229
20negative regulation of neurotransmitter transport (GO:0051589)3.39508644
21negative regulation of thymocyte apoptotic process (GO:0070244)3.35098854
22regulation of integrin-mediated signaling pathway (GO:2001044)3.34647998
23G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.34579490
24regulation of MHC class II biosynthetic process (GO:0045346)3.33775791
25platelet dense granule organization (GO:0060155)3.32401935
26neutrophil activation (GO:0042119)3.29014373
27regulation of B cell receptor signaling pathway (GO:0050855)3.25677831
28negative regulation of response to food (GO:0032096)3.25443646
29negative regulation of appetite (GO:0032099)3.25443646
30indolalkylamine metabolic process (GO:0006586)3.22278003
31negative regulation of protein localization to cell surface (GO:2000009)3.21879626
32positive regulation of granulocyte differentiation (GO:0030854)3.19710230
33negative regulation of norepinephrine secretion (GO:0010700)3.16886429
34positive regulation of endothelial cell differentiation (GO:0045603)3.15078748
35termination of G-protein coupled receptor signaling pathway (GO:0038032)3.12682633
36tachykinin receptor signaling pathway (GO:0007217)3.03407501
37tryptophan catabolic process (GO:0006569)3.03231716
38indole-containing compound catabolic process (GO:0042436)3.03231716
39indolalkylamine catabolic process (GO:0046218)3.03231716
40regulation of Golgi to plasma membrane protein transport (GO:0042996)3.02329808
41negative regulation of platelet activation (GO:0010544)3.00811149
42fusion of sperm to egg plasma membrane (GO:0007342)2.99352717
43adenosine metabolic process (GO:0046085)2.98225686
44regulation of lipoprotein metabolic process (GO:0050746)2.97455647
45negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.96669698
46termination of signal transduction (GO:0023021)2.89357027
47purinergic receptor signaling pathway (GO:0035587)2.82518455
48autophagic vacuole fusion (GO:0000046)2.82131680
49megakaryocyte development (GO:0035855)2.80055169
50negative regulation of T-helper cell differentiation (GO:0045623)2.79848062
51negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.79848062
52regulation of female receptivity (GO:0045924)2.79818834
53phosphatidylinositol acyl-chain remodeling (GO:0036149)2.79584176
54phospholipid homeostasis (GO:0055091)2.78375218
55regulation of mast cell activation (GO:0033003)2.78008877
56low-density lipoprotein particle remodeling (GO:0034374)2.76583647
57platelet aggregation (GO:0070527)2.75298950
58negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.71044115
59granulocyte activation (GO:0036230)2.68928643
60negative regulation of mast cell activation (GO:0033004)2.66297179
61monoamine transport (GO:0015844)2.62835573
62neural tube formation (GO:0001841)2.62231161
63adenosine receptor signaling pathway (GO:0001973)2.60281949
64regulation of endothelial cell differentiation (GO:0045601)2.59300002
65regulation of macrophage derived foam cell differentiation (GO:0010743)2.58915473
66negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744)2.57168295
67angiogenesis involved in wound healing (GO:0060055)2.55375608
68organelle membrane fusion (GO:0090174)2.53182350
69adaptation of signaling pathway (GO:0023058)2.52871115
70negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.52245636
71aromatic amino acid family catabolic process (GO:0009074)2.52124625
72cardiolipin metabolic process (GO:0032048)2.51726094
73tryptophan metabolic process (GO:0006568)2.49966112
74negative regulation of homotypic cell-cell adhesion (GO:0034111)2.48412129
75detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.46506771
76kynurenine metabolic process (GO:0070189)2.45036940
77reverse cholesterol transport (GO:0043691)2.44111689
78neuronal action potential propagation (GO:0019227)2.44009474
79high-density lipoprotein particle remodeling (GO:0034375)2.43208854
80pyrimidine nucleoside catabolic process (GO:0046135)2.42591816
81cell wall macromolecule metabolic process (GO:0044036)2.40693334
82activated T cell proliferation (GO:0050798)2.39998163
83regulation of regulatory T cell differentiation (GO:0045589)2.39514692
84regulation of cilium movement (GO:0003352)2.39140982
85regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.39115643
86positive regulation of steroid hormone secretion (GO:2000833)2.38666122
87tyrosine phosphorylation of STAT protein (GO:0007260)2.35957028
88regulation of norepinephrine secretion (GO:0014061)2.35788623
89cilium or flagellum-dependent cell motility (GO:0001539)2.35179576
90rhodopsin mediated signaling pathway (GO:0016056)2.33477120
91negative regulation of heart contraction (GO:0045822)2.32820759
92positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.32482498
93cellular biogenic amine biosynthetic process (GO:0042401)2.32472828
94negative regulation of T cell apoptotic process (GO:0070233)2.31956017
95detection of light stimulus involved in sensory perception (GO:0050962)2.30673578
96detection of light stimulus involved in visual perception (GO:0050908)2.30673578
97female mating behavior (GO:0060180)2.30672956
98negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.29565731
99regulation of homotypic cell-cell adhesion (GO:0034110)2.28770954
100establishment of protein localization to Golgi (GO:0072600)2.28364756

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.17334032
2EZH2_22144423_ChIP-Seq_EOC_Human3.00272583
3VDR_22108803_ChIP-Seq_LS180_Human2.72741605
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.72134589
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.53352705
6LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.46074685
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.42412395
8SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.31839343
9TAF15_26573619_Chip-Seq_HEK293_Human2.25138709
10SCL_19346495_ChIP-Seq_HPC-7_Human2.20650725
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.17288694
12IGF1R_20145208_ChIP-Seq_DFB_Human2.15842537
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.12864535
14AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.95582037
15ZNF274_21170338_ChIP-Seq_K562_Hela1.92498033
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.84142645
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83168378
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.82514133
19EWS_26573619_Chip-Seq_HEK293_Human1.76698617
20GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.73047813
21ER_23166858_ChIP-Seq_MCF-7_Human1.70716974
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70241661
23P300_19829295_ChIP-Seq_ESCs_Human1.68257457
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67081350
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63841396
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63403666
27SMAD4_21799915_ChIP-Seq_A2780_Human1.63078210
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61688378
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.57418944
30BCAT_22108803_ChIP-Seq_LS180_Human1.56801448
31STAT3_23295773_ChIP-Seq_U87_Human1.56164735
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53414913
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.51856088
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50602158
35EZH2_27294783_Chip-Seq_NPCs_Mouse1.49875992
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48138854
37AR_25329375_ChIP-Seq_VCAP_Human1.45557683
38TCF4_23295773_ChIP-Seq_U87_Human1.43823389
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42943739
40FUS_26573619_Chip-Seq_HEK293_Human1.41074421
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36373135
42RUNX_20019798_ChIP-Seq_JUKART_Human1.35738678
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34432695
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.33628444
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33541250
46TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33222206
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29385076
48MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.27967323
49HTT_18923047_ChIP-ChIP_STHdh_Human1.27758024
50NANOG_19829295_ChIP-Seq_ESCs_Human1.27079290
51SOX2_19829295_ChIP-Seq_ESCs_Human1.27079290
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27035562
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25973901
54TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24490696
55CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23724104
56PRDM14_20953172_ChIP-Seq_ESCs_Human1.23250722
57IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22328816
58FLI1_21867929_ChIP-Seq_TH2_Mouse1.21927627
59PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21183293
60P53_22387025_ChIP-Seq_ESCs_Mouse1.21163722
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20805184
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20805184
63CBP_20019798_ChIP-Seq_JUKART_Human1.20014180
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20014180
65CRX_20693478_ChIP-Seq_RETINA_Mouse1.19059190
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.18915948
67TCF4_22108803_ChIP-Seq_LS180_Human1.16632811
68OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16005049
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15914749
70EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15818386
71IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.15559076
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15179535
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15179535
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.14751727
75GATA3_26560356_Chip-Seq_TH2_Human1.12332812
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11808894
77GATA2_19941826_ChIP-Seq_K562_Human1.11685388
78IRF8_22096565_ChIP-ChIP_GC-B_Human1.10744298
79Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10406398
80CDX2_22108803_ChIP-Seq_LS180_Human1.10343613
81FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10029795
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09565069
83E2F1_18555785_Chip-Seq_ESCs_Mouse1.09117097
84GATA1_19941826_ChIP-Seq_K562_Human1.09023721
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.08532285
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.08506620
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08506620
88TP53_16413492_ChIP-PET_HCT116_Human1.07876401
89RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07567342
90RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07453312
91SMAD4_21741376_ChIP-Seq_EPCs_Human1.03800494
92AR_20517297_ChIP-Seq_VCAP_Human1.03021606
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03002539
94GATA3_21878914_ChIP-Seq_MCF-7_Human1.02841775
95CMYC_18555785_Chip-Seq_ESCs_Mouse1.02783711
96SMRT_27268052_Chip-Seq_Bcells_Human1.02094577
97TP53_22573176_ChIP-Seq_HFKS_Human1.00636793
98RUNX2_22187159_ChIP-Seq_PCA_Human0.99846537
99GATA1_22025678_ChIP-Seq_K562_Human0.99654750
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99093249

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology6.33851987
2MP0003724_increased_susceptibility_to2.95490949
3MP0000569_abnormal_digit_pigmentation2.88772226
4MP0008004_abnormal_stomach_pH2.82070772
5MP0002736_abnormal_nociception_after2.39440584
6MP0008872_abnormal_physiological_respon2.26430053
7MP0005646_abnormal_pituitary_gland2.23125919
8MP0005167_abnormal_blood-brain_barrier2.13389167
9MP0001968_abnormal_touch/_nociception2.13165973
10MP0000230_abnormal_systemic_arterial2.10092437
11MP0001835_abnormal_antigen_presentation2.08479646
12MP0000465_gastrointestinal_hemorrhage1.98672408
13MP0008877_abnormal_DNA_methylation1.85464980
14MP0005084_abnormal_gallbladder_morpholo1.80523575
15MP0004130_abnormal_muscle_cell1.78138859
16MP0004084_abnormal_cardiac_muscle1.77307633
17MP0008775_abnormal_heart_ventricle1.75565392
18MP0003195_calcinosis1.73889260
19MP0005551_abnormal_eye_electrophysiolog1.66579158
20MP0003646_muscle_fatigue1.65956498
21MP0005410_abnormal_fertilization1.63898200
22MP0005671_abnormal_response_to1.63292784
23MP0005083_abnormal_biliary_tract1.59348243
24MP0005645_abnormal_hypothalamus_physiol1.58169980
25MP0001501_abnormal_sleep_pattern1.57439459
26MP0004142_abnormal_muscle_tone1.55723402
27MP0004510_myositis1.50648947
28MP0002102_abnormal_ear_morphology1.45839912
29MP0005174_abnormal_tail_pigmentation1.44972824
30MP0010329_abnormal_lipoprotein_level1.43082358
31MP0006276_abnormal_autonomic_nervous1.41155606
32MP0003638_abnormal_response/metabolism_1.35578681
33MP0009046_muscle_twitch1.31693321
34MP0002733_abnormal_thermal_nociception1.30512024
35MP0009764_decreased_sensitivity_to1.27386742
36MP0004036_abnormal_muscle_relaxation1.23130009
37MP0004147_increased_porphyrin_level1.22730907
38MP0006054_spinal_hemorrhage1.21022160
39MP0003011_delayed_dark_adaptation1.19805638
40MP0001800_abnormal_humoral_immune1.19409851
41MP0002876_abnormal_thyroid_physiology1.18783976
42MP0004043_abnormal_pH_regulation1.18441266
43MP0001970_abnormal_pain_threshold1.18057920
44MP0000372_irregular_coat_pigmentation1.14998157
45MP0004215_abnormal_myocardial_fiber1.14961704
46MP0001879_abnormal_lymphatic_vessel1.14107565
47MP0004484_altered_response_of1.13675713
48MP0010386_abnormal_urinary_bladder1.12919582
49MP0005000_abnormal_immune_tolerance1.12599886
50MP0000383_abnormal_hair_follicle1.10792576
51MP0009745_abnormal_behavioral_response1.10189337
52MP0002723_abnormal_immune_serum1.10090987
53MP0003828_pulmonary_edema1.09718176
54MP0003787_abnormal_imprinting1.09522079
55MP0000015_abnormal_ear_pigmentation1.08063608
56MP0002398_abnormal_bone_marrow1.05547890
57MP0003656_abnormal_erythrocyte_physiolo1.04478477
58MP0003879_abnormal_hair_cell1.04462183
59MP0002638_abnormal_pupillary_reflex1.04017487
60MP0001664_abnormal_digestion1.02533030
61MP0003866_abnormal_defecation1.01829381
62MP0005253_abnormal_eye_physiology1.01748583
63MP0003045_fibrosis1.01580556
64MP0002148_abnormal_hypersensitivity_rea1.01361198
65MP0000343_altered_response_to1.00444893
66MP0002693_abnormal_pancreas_physiology0.99620364
67MP0002735_abnormal_chemical_nociception0.98722411
68MP0008875_abnormal_xenobiotic_pharmacok0.98006442
69MP0000689_abnormal_spleen_morphology0.97882717
70MP0004883_abnormal_blood_vessel0.95948673
71MP0005535_abnormal_body_temperature0.94074180
72MP0001986_abnormal_taste_sensitivity0.92318681
73MP0001851_eye_inflammation0.92312747
74MP0005397_hematopoietic_system_phenotyp0.91022452
75MP0001545_abnormal_hematopoietic_system0.91022452
76MP0002452_abnormal_antigen_presenting0.90863782
77MP0008961_abnormal_basal_metabolism0.89621212
78MP0004085_abnormal_heartbeat0.88646448
79MP0001663_abnormal_digestive_system0.88008416
80MP0010155_abnormal_intestine_physiology0.87277972
81MP0009780_abnormal_chondrocyte_physiolo0.84238713
82MP0000249_abnormal_blood_vessel0.84138506
83MP0001765_abnormal_ion_homeostasis0.83963221
84MP0002272_abnormal_nervous_system0.83747032
85MP0002420_abnormal_adaptive_immunity0.83746222
86MP0003763_abnormal_thymus_physiology0.81826393
87MP0001819_abnormal_immune_cell0.81728188
88MP0003718_maternal_effect0.80969668
89MP0001756_abnormal_urination0.80841528
90MP0002132_abnormal_respiratory_system0.79467101
91MP0003252_abnormal_bile_duct0.78113761
92MP0002837_dystrophic_cardiac_calcinosis0.77421334
93MP0000685_abnormal_immune_system0.75959197
94MP0009765_abnormal_xenobiotic_induced0.75908794
95MP0009642_abnormal_blood_homeostasis0.75370861
96MP0002118_abnormal_lipid_homeostasis0.75198744
97MP0002067_abnormal_sensory_capabilities0.75090525
98MP0005448_abnormal_energy_balance0.73895164
99MP0000716_abnormal_immune_system0.72223083
100MP0005670_abnormal_white_adipose0.72137060

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)8.17929253
2Menorrhagia (HP:0000132)7.07324535
3Increased mean platelet volume (HP:0011877)6.63509543
4Abnormal platelet volume (HP:0011876)6.24857119
5Petechiae (HP:0000967)6.18069571
6Epistaxis (HP:0000421)5.34850573
7Purpura (HP:0000979)5.33423611
8Gingival bleeding (HP:0000225)4.66834605
9Hyperlipoproteinemia (HP:0010980)4.61626479
10Abnormal platelet function (HP:0011869)3.45984690
11Impaired platelet aggregation (HP:0003540)3.45984690
12Pancreatic cysts (HP:0001737)3.32000639
13Poikilocytosis (HP:0004447)3.30653806
14Dyschromatopsia (HP:0007641)3.20540992
15Abnormality of the renal cortex (HP:0011035)3.11339237
16Acanthocytosis (HP:0001927)2.96527289
17Decreased central vision (HP:0007663)2.94275797
18Spontaneous hematomas (HP:0007420)2.92021998
19Stomatitis (HP:0010280)2.89050149
20Congenital stationary night blindness (HP:0007642)2.82103163
21Febrile seizures (HP:0002373)2.79512590
22Renal cortical cysts (HP:0000803)2.67714077
23Hyperventilation (HP:0002883)2.66324949
24Increased density of long bones (HP:0006392)2.64915697
25Thyroid-stimulating hormone excess (HP:0002925)2.58779365
26Pancreatic fibrosis (HP:0100732)2.56643964
27Abnormality of the heme biosynthetic pathway (HP:0010472)2.56601995
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.55489778
29Abnormality of alanine metabolism (HP:0010916)2.55489778
30Hyperalaninemia (HP:0003348)2.55489778
31Attenuation of retinal blood vessels (HP:0007843)2.55014026
32Abnormal pupillary function (HP:0007686)2.47311172
33Gaze-evoked nystagmus (HP:0000640)2.34696582
34Abolished electroretinogram (ERG) (HP:0000550)2.33687416
35True hermaphroditism (HP:0010459)2.33546955
36Conjunctival telangiectasia (HP:0000524)2.32995113
37Clumsiness (HP:0002312)2.27425050
38Medial flaring of the eyebrow (HP:0010747)2.25992253
39Abnormal ciliary motility (HP:0012262)2.25878867
40Abnormality of midbrain morphology (HP:0002418)2.25837947
41Molar tooth sign on MRI (HP:0002419)2.25837947
423-Methylglutaconic aciduria (HP:0003535)2.25565036
43Bruising susceptibility (HP:0000978)2.24363718
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.21968332
45Absent/shortened dynein arms (HP:0200106)2.21968332
46Congenital sensorineural hearing impairment (HP:0008527)2.19390601
47Tinnitus (HP:0000360)2.16406330
48Abnormality of the common coagulation pathway (HP:0010990)2.10125639
49Polydipsia (HP:0001959)2.07081246
50Abnormal drinking behavior (HP:0030082)2.07081246
51Joint swelling (HP:0001386)2.04212786
52Progressive cerebellar ataxia (HP:0002073)2.01242350
53Genetic anticipation (HP:0003743)2.01014799
54Nephronophthisis (HP:0000090)2.00860464
55Abnormality of the vasculature of the conjunctiva (HP:0008054)2.00466339
56Abnormality of the renal medulla (HP:0100957)1.99654871
57Central scotoma (HP:0000603)1.96233935
58Paralysis (HP:0003470)1.94238272
59Abnormality of the prostate (HP:0008775)1.94102736
60Abnormal respiratory motile cilium morphology (HP:0005938)1.92120973
61Abnormal respiratory epithelium morphology (HP:0012253)1.92120973
62Atonic seizures (HP:0010819)1.90886505
63Widely spaced teeth (HP:0000687)1.90872289
64Spontaneous abortion (HP:0005268)1.82026243
65Cystic liver disease (HP:0006706)1.81209092
66Abnormality of lateral ventricle (HP:0030047)1.81088143
67Generalized aminoaciduria (HP:0002909)1.80795685
68Encephalitis (HP:0002383)1.80583744
69Polyphagia (HP:0002591)1.79545553
70Abnormal rod and cone electroretinograms (HP:0008323)1.74604950
71Abnormal auditory evoked potentials (HP:0006958)1.74248246
72Xanthomatosis (HP:0000991)1.72028638
73Abnormality of transition element cation homeostasis (HP:0011030)1.71677485
74Chronic hepatic failure (HP:0100626)1.71309942
75Hypothermia (HP:0002045)1.68453542
76Absent speech (HP:0001344)1.67806359
77Enlarged kidneys (HP:0000105)1.65310756
78Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.64041916
79Arthropathy (HP:0003040)1.63926371
80Protruding tongue (HP:0010808)1.62400074
81Dialeptic seizures (HP:0011146)1.62174585
82Abnormal respiratory motile cilium physiology (HP:0012261)1.61744217
83Absent rod-and cone-mediated responses on ERG (HP:0007688)1.59979747
84Tongue fasciculations (HP:0001308)1.59708790
85Tubular atrophy (HP:0000092)1.59389925
86Congenital hepatic fibrosis (HP:0002612)1.57751222
87Biliary tract neoplasm (HP:0100574)1.57308153
88Polyuria (HP:0000103)1.57171622
89Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.57104350
90Autoimmune thrombocytopenia (HP:0001973)1.56704932
91Pancreatic islet-cell hyperplasia (HP:0004510)1.55853803
92Arterial thrombosis (HP:0004420)1.54907661
93Inability to walk (HP:0002540)1.54901373
94Fair hair (HP:0002286)1.54755883
95Episodic fever (HP:0001954)1.54642508
96Diplopia (HP:0000651)1.54622283
97Abnormality of binocular vision (HP:0011514)1.54622283
98Hypoplastic iliac wings (HP:0002866)1.52719848
99Lissencephaly (HP:0001339)1.52154119
100IgG deficiency (HP:0004315)1.51899082

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.51789100
2ACVR1B3.29116394
3RIPK42.99053644
4TAOK32.96921465
5MST42.88447095
6TEC2.72250060
7ADRBK22.41065065
8BMPR1B2.35504834
9TXK2.23938674
10PIK3CG2.14650821
11PTK2B1.98635805
12BTK1.90761024
13NUAK11.89800813
14BMX1.78555948
15MYLK1.77857254
16MAP4K21.71677101
17SYK1.66595810
18GRK51.62676898
19GRK11.61999863
20MAPK131.57933261
21CAMKK21.55370287
22BMPR21.52227679
23EIF2AK11.45319159
24CSF1R1.38537517
25TNK21.36533399
26DAPK21.34466270
27ADRBK11.27234198
28ITK1.24679587
29INSRR1.18666446
30STK31.18279095
31MAPKAPK31.15419965
32PINK11.13922391
33TNIK1.10893208
34STK241.10475602
35IKBKB1.08744202
36ZAK1.07508401
37STK391.03579273
38HCK0.98254470
39IRAK10.97859098
40GRK60.96890164
41PAK30.93969411
42PLK20.92138793
43WNK40.89989759
44LYN0.89580467
45ZAP700.87900208
46WNK30.82553932
47FES0.80069517
48TRIM280.76396356
49BLK0.75172354
50ILK0.72088368
51FER0.71843784
52NTRK30.71543765
53PNCK0.70773059
54PRKCE0.70604945
55TRPM70.69911148
56NLK0.69631643
57FGR0.69386541
58AKT30.68923933
59PRKCQ0.67877166
60EPHA30.66213532
61PDK10.65983744
62OXSR10.63929188
63MAP3K40.63574995
64KIT0.62781803
65ERBB20.62707070
66BRSK20.60878937
67PKN10.60352582
68JAK30.58887557
69CAMK10.58656924
70MARK30.53020135
71PHKG10.52943433
72PHKG20.52943433
73LCK0.51670972
74GRK70.51592756
75PRKG10.50644026
76JAK10.50195966
77FLT30.49639279
78MAP2K10.49101795
79SGK20.48512873
80TGFBR10.45414244
81PRKCG0.43813735
82PRKACG0.42147271
83DYRK1A0.41577809
84PIK3CA0.41427928
85MAP4K10.40356712
86MATK0.39279041
87CAMK2A0.38766257
88ERBB30.38139033
89JAK20.36884581
90MKNK20.35451038
91PRKD10.34982913
92CAMK1G0.34337737
93ABL10.34138688
94PRKAA20.34056794
95IGF1R0.33156630
96PRKACA0.32749596
97MAP3K20.32357266
98TLK10.32211568
99CCNB10.31384360
100PRKCA0.30473858

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046113.70125963
2Nitrogen metabolism_Homo sapiens_hsa009102.69575618
3SNARE interactions in vesicular transport_Homo sapiens_hsa041302.54824279
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.39757949
5Phototransduction_Homo sapiens_hsa047442.33439092
6Linoleic acid metabolism_Homo sapiens_hsa005912.33316137
7Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.18427356
8Arachidonic acid metabolism_Homo sapiens_hsa005901.93897392
9Serotonergic synapse_Homo sapiens_hsa047261.83187831
10Olfactory transduction_Homo sapiens_hsa047401.74117642
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68723777
12Vascular smooth muscle contraction_Homo sapiens_hsa042701.65168707
13Hematopoietic cell lineage_Homo sapiens_hsa046401.64896222
14Morphine addiction_Homo sapiens_hsa050321.55922191
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54557023
16Circadian entrainment_Homo sapiens_hsa047131.50808776
17ABC transporters_Homo sapiens_hsa020101.46595205
18Glycerolipid metabolism_Homo sapiens_hsa005611.37828495
19Caffeine metabolism_Homo sapiens_hsa002321.37811863
20Butanoate metabolism_Homo sapiens_hsa006501.35716479
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.27513954
22Long-term depression_Homo sapiens_hsa047301.27200355
23Ether lipid metabolism_Homo sapiens_hsa005651.26676213
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22205284
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21904485
26Chemokine signaling pathway_Homo sapiens_hsa040621.17515801
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16201185
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.15842148
29Collecting duct acid secretion_Homo sapiens_hsa049661.14916590
30GABAergic synapse_Homo sapiens_hsa047271.14512075
31Graft-versus-host disease_Homo sapiens_hsa053321.13921994
32Calcium signaling pathway_Homo sapiens_hsa040201.13472325
33Regulation of autophagy_Homo sapiens_hsa041401.12988699
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.08096885
35Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04544339
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.03394843
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03305085
38Chemical carcinogenesis_Homo sapiens_hsa052041.00863595
39Primary immunodeficiency_Homo sapiens_hsa053400.99948994
40Renin secretion_Homo sapiens_hsa049240.98756644
41Salivary secretion_Homo sapiens_hsa049700.97648616
42Tryptophan metabolism_Homo sapiens_hsa003800.96510819
43Pancreatic secretion_Homo sapiens_hsa049720.96264837
44Dorso-ventral axis formation_Homo sapiens_hsa043200.92945314
45Nicotine addiction_Homo sapiens_hsa050330.92674498
46Glutamatergic synapse_Homo sapiens_hsa047240.92511943
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92291628
48Asthma_Homo sapiens_hsa053100.91920248
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90527276
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88186465
51Taste transduction_Homo sapiens_hsa047420.87775473
52T cell receptor signaling pathway_Homo sapiens_hsa046600.87134670
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86760338
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85161601
55Type I diabetes mellitus_Homo sapiens_hsa049400.81840560
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81782153
57Glycerophospholipid metabolism_Homo sapiens_hsa005640.80802795
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80586031
59Ovarian steroidogenesis_Homo sapiens_hsa049130.80577864
60beta-Alanine metabolism_Homo sapiens_hsa004100.77528985
61Allograft rejection_Homo sapiens_hsa053300.77044516
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76158520
63ECM-receptor interaction_Homo sapiens_hsa045120.74299846
64Autoimmune thyroid disease_Homo sapiens_hsa053200.73328977
65Retinol metabolism_Homo sapiens_hsa008300.73240093
66Gap junction_Homo sapiens_hsa045400.73024454
67Oxytocin signaling pathway_Homo sapiens_hsa049210.72813042
68Cholinergic synapse_Homo sapiens_hsa047250.71149656
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68577728
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66258552
71Circadian rhythm_Homo sapiens_hsa047100.65053751
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65027175
73Alcoholism_Homo sapiens_hsa050340.64667192
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64137192
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.63139755
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62476519
77B cell receptor signaling pathway_Homo sapiens_hsa046620.61987369
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60523575
79Systemic lupus erythematosus_Homo sapiens_hsa053220.59608593
80Fatty acid elongation_Homo sapiens_hsa000620.57989234
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.56884718
82Gastric acid secretion_Homo sapiens_hsa049710.56373745
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55821478
84Ras signaling pathway_Homo sapiens_hsa040140.55440855
85Type II diabetes mellitus_Homo sapiens_hsa049300.53752101
86Staphylococcus aureus infection_Homo sapiens_hsa051500.53701636
87Insulin secretion_Homo sapiens_hsa049110.53469935
88Sphingolipid metabolism_Homo sapiens_hsa006000.51503354
89cAMP signaling pathway_Homo sapiens_hsa040240.46335735
90Homologous recombination_Homo sapiens_hsa034400.45879675
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45678299
92Dopaminergic synapse_Homo sapiens_hsa047280.45560881
93Selenocompound metabolism_Homo sapiens_hsa004500.44559393
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43730179
95Choline metabolism in cancer_Homo sapiens_hsa052310.43521631
96Rheumatoid arthritis_Homo sapiens_hsa053230.39566190
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39499050
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39073101
99Sulfur metabolism_Homo sapiens_hsa009200.38813206
100Amphetamine addiction_Homo sapiens_hsa050310.38234083

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