WFS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations in this gene are associated with Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), an autosomal recessive disorder. The disease affects the brain and central nervous system. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.46389981
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.34217379
3cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.24714222
4vocalization behavior (GO:0071625)4.16791016
5locomotory exploration behavior (GO:0035641)4.12514428
6synaptic vesicle maturation (GO:0016188)4.02875005
7ionotropic glutamate receptor signaling pathway (GO:0035235)3.98340230
8membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.92211719
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.86299047
10Golgi transport vesicle coating (GO:0048200)3.84573119
11COPI coating of Golgi vesicle (GO:0048205)3.84573119
12cell communication by electrical coupling (GO:0010644)3.82953696
13plasma membrane repair (GO:0001778)3.76875683
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.74412114
15regulation of synapse structural plasticity (GO:0051823)3.71303883
16detection of calcium ion (GO:0005513)3.70774866
17regulation of glutamate receptor signaling pathway (GO:1900449)3.70382475
18regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.69800585
19synaptic vesicle exocytosis (GO:0016079)3.64768336
20regulation of long-term neuronal synaptic plasticity (GO:0048169)3.61599178
21positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.59151610
22regulation of synaptic vesicle exocytosis (GO:2000300)3.58486996
23glutamate receptor signaling pathway (GO:0007215)3.55797137
24regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.53523969
25protein retention in ER lumen (GO:0006621)3.52764988
26regulation of neuronal synaptic plasticity (GO:0048168)3.49744573
27maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.46221653
28neuronal action potential propagation (GO:0019227)3.40587126
29regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.39130991
30exploration behavior (GO:0035640)3.39027442
31activation of protein kinase A activity (GO:0034199)3.38208055
32regulation of synaptic vesicle transport (GO:1902803)3.37686585
33cellular potassium ion homeostasis (GO:0030007)3.35942670
34cell communication involved in cardiac conduction (GO:0086065)3.34828767
35protein localization to synapse (GO:0035418)3.34447965
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.34031768
37sarcoplasmic reticulum calcium ion transport (GO:0070296)3.33116696
38G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.32842760
39synaptic transmission, glutamatergic (GO:0035249)3.29687629
40synaptic vesicle docking involved in exocytosis (GO:0016081)3.28897739
41cytoskeletal anchoring at plasma membrane (GO:0007016)3.27417925
42regulation of excitatory postsynaptic membrane potential (GO:0060079)3.16903799
43glutamate secretion (GO:0014047)3.16554498
44regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.16158771
45sodium ion export (GO:0071436)3.15013457
46regulation of dendritic spine morphogenesis (GO:0061001)3.13618655
47long-term memory (GO:0007616)3.13046085
48regulation of calcium ion transmembrane transporter activity (GO:1901019)3.11499742
49regulation of calcium ion transmembrane transport (GO:1903169)3.11499742
50neuron-neuron synaptic transmission (GO:0007270)3.09747030
51regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.09296047
52positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.09001145
53regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.08082686
54skin morphogenesis (GO:0043589)3.05712125
55innervation (GO:0060384)3.05008436
56desmosome organization (GO:0002934)3.04231545
57positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.03784089
58regulation of synaptic plasticity (GO:0048167)3.03620941
59vesicle transport along microtubule (GO:0047496)3.03544559
60regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.02642841
61basement membrane organization (GO:0071711)3.00925218
62negative regulation of cytosolic calcium ion concentration (GO:0051481)3.00770289
63striatum development (GO:0021756)3.00474119
64behavioral fear response (GO:0001662)2.99936430
65behavioral defense response (GO:0002209)2.99936430
66regulation of postsynaptic membrane potential (GO:0060078)2.97063329
67negative regulation of potassium ion transmembrane transport (GO:1901380)2.95139012
68retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.94207890
69regulation of membrane repolarization (GO:0060306)2.94137927
70dendritic spine morphogenesis (GO:0060997)2.93579678
71dendritic spine organization (GO:0097061)2.91818432
72negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.91594072
73neuron recognition (GO:0008038)2.91165704
74neurotransmitter secretion (GO:0007269)2.90111591
75neuron cell-cell adhesion (GO:0007158)2.87993123
76planar cell polarity pathway involved in neural tube closure (GO:0090179)2.87220217
77fear response (GO:0042596)2.87200609
78membrane depolarization during action potential (GO:0086010)2.87051178
79long term synaptic depression (GO:0060292)2.86894545
80potassium ion import (GO:0010107)2.86220585
81membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.84793985
82long-term synaptic potentiation (GO:0060291)2.84646438
83negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.83995869
84epithelial cell-cell adhesion (GO:0090136)2.81902722
85regulation of female receptivity (GO:0045924)2.80748260
86regulation of extracellular matrix disassembly (GO:0010715)2.80691895
87regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.80170116
88regulation of vesicle fusion (GO:0031338)2.77226458
89gamma-aminobutyric acid signaling pathway (GO:0007214)2.76967473
90neuromuscular process controlling balance (GO:0050885)2.76884903
91positive regulation of synaptic transmission, GABAergic (GO:0032230)2.76382246
92adherens junction assembly (GO:0034333)2.76298884
93neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.74833859
94regulation of potassium ion transmembrane transport (GO:1901379)2.72697986
95neuronal ion channel clustering (GO:0045161)2.72662135
96positive regulation of potassium ion transmembrane transport (GO:1901381)2.72588301
97layer formation in cerebral cortex (GO:0021819)2.71745122
98apoptotic cell clearance (GO:0043277)2.71637330
99regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.71240826
100calcium-mediated signaling using intracellular calcium source (GO:0035584)2.71232789
101positive regulation of membrane potential (GO:0045838)2.69750920
102negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.69265360
103negative regulation of calcium ion transmembrane transport (GO:1903170)2.69265360
104inner ear receptor cell development (GO:0060119)2.69115048
105membrane repolarization (GO:0086009)2.69100411
106positive regulation of synapse maturation (GO:0090129)2.68836847
107cardiac muscle contraction (GO:0060048)2.67139830
108positive regulation of vesicle fusion (GO:0031340)2.66940335
109axonal fasciculation (GO:0007413)2.66933380
110female mating behavior (GO:0060180)2.66802749
111regulation of ion transmembrane transporter activity (GO:0032412)2.66427984
112negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.66268675
113neurotransmitter-gated ion channel clustering (GO:0072578)2.66084535
114proline transport (GO:0015824)2.65650590
115relaxation of cardiac muscle (GO:0055119)2.64735330
116positive regulation of potassium ion transport (GO:0043268)2.63741182
117regulation of cholesterol biosynthetic process (GO:0045540)2.58933401
118regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.55769921
119protein heterotrimerization (GO:0070208)2.50775040
120lung epithelium development (GO:0060428)2.48004132
121cell-substrate adherens junction assembly (GO:0007045)2.47599610
122focal adhesion assembly (GO:0048041)2.47599610
123L-serine transport (GO:0015825)2.46156884
124cell volume homeostasis (GO:0006884)2.44372387
125endocardial cushion development (GO:0003197)2.42864796
126endothelial cell morphogenesis (GO:0001886)2.42401709
127fatty acid homeostasis (GO:0055089)2.41956871
128glomerular basement membrane development (GO:0032836)2.40880267
129embryonic retina morphogenesis in camera-type eye (GO:0060059)2.40826565
130cell-substrate junction assembly (GO:0007044)2.40653943
131endothelial cell chemotaxis (GO:0035767)2.38819666
132chondrocyte proliferation (GO:0035988)2.38780813
133semaphorin-plexin signaling pathway (GO:0071526)2.38173810
134regulation of cholesterol homeostasis (GO:2000188)2.36139827
135peptidyl-glutamic acid carboxylation (GO:0017187)2.35010603
136protein carboxylation (GO:0018214)2.35010603
137establishment of apical/basal cell polarity (GO:0035089)2.33114605
138cerebellar Purkinje cell layer development (GO:0021680)2.28103886
139vascular endothelial growth factor signaling pathway (GO:0038084)2.28078626
140endocrine hormone secretion (GO:0060986)2.27309176
141branching involved in salivary gland morphogenesis (GO:0060445)2.26849543
142retina vasculature morphogenesis in camera-type eye (GO:0061299)2.23955835
143regulation of cardioblast differentiation (GO:0051890)2.23409233
144cellular zinc ion homeostasis (GO:0006882)2.22918828
145macroautophagy (GO:0016236)2.21841288
1464-hydroxyproline metabolic process (GO:0019471)2.17372064
147COPII vesicle coating (GO:0048208)2.16895738
148Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.13317306
149vesicle coating (GO:0006901)2.12378350
150bundle of His cell to Purkinje myocyte communication (GO:0086069)2.12230748
151cell-cell junction maintenance (GO:0045217)2.12174040
152negative regulation of chondrocyte differentiation (GO:0032331)2.10833153
153hemidesmosome assembly (GO:0031581)2.10520037
154NADH metabolic process (GO:0006734)2.09994220
155barbed-end actin filament capping (GO:0051016)2.09800303
156extracellular fibril organization (GO:0043206)2.09768266
157atrioventricular valve morphogenesis (GO:0003181)2.08468661
158negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.06941737
159negative regulation of hormone biosynthetic process (GO:0032353)2.06690262
160regulation of cholesterol metabolic process (GO:0090181)2.05862730
161regulation of steroid hormone biosynthetic process (GO:0090030)2.05568280
162insulin-like growth factor receptor signaling pathway (GO:0048009)2.05395726
163* activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.03634597
164positive regulation of receptor recycling (GO:0001921)2.03535641
165type B pancreatic cell proliferation (GO:0044342)2.03391254
166cellular sodium ion homeostasis (GO:0006883)2.03384528
167paraxial mesoderm development (GO:0048339)2.01856263
168extracellular matrix assembly (GO:0085029)2.01836867
169surfactant homeostasis (GO:0043129)2.01289323
170cell adhesion mediated by integrin (GO:0033627)1.99662573
171low-density lipoprotein particle clearance (GO:0034383)1.99650241
172regulation of glucose import in response to insulin stimulus (GO:2001273)1.99090697
173regulation of integrin-mediated signaling pathway (GO:2001044)1.99010388
174negative regulation of hormone metabolic process (GO:0032351)1.97979954
175renal absorption (GO:0070293)1.97438112
176embryo implantation (GO:0007566)1.97400557
177regulation of establishment of planar polarity (GO:0090175)1.97386818
178protein targeting to plasma membrane (GO:0072661)1.96942418
179non-canonical Wnt signaling pathway (GO:0035567)1.96403105
180regulation of glucocorticoid metabolic process (GO:0031943)1.95707624
181regulation of extracellular matrix organization (GO:1903053)1.95568019
182endodermal cell differentiation (GO:0035987)1.94922509
183glomerular epithelial cell development (GO:0072310)1.94466894
184vascular endothelial growth factor receptor signaling pathway (GO:0048010)1.94376621
185erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)1.93547805
186L-phenylalanine metabolic process (GO:0006558)1.93547805
187dichotomous subdivision of an epithelial terminal unit (GO:0060600)1.92739668
188positive regulation of steroid biosynthetic process (GO:0010893)1.91912997
189protein localization to endosome (GO:0036010)1.91852295
190branching involved in mammary gland duct morphogenesis (GO:0060444)1.91193866

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.54550524
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.38718487
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.30342646
4GBX2_23144817_ChIP-Seq_PC3_Human3.01417355
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95776398
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.90462751
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.88740262
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.79957297
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.73716361
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.69243688
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.63421318
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.63045758
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52565373
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52565373
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50376616
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49593291
17REST_21632747_ChIP-Seq_MESCs_Mouse2.46150381
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44129239
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44071514
20CLOCK_20551151_ChIP-Seq_293T_Human2.43920754
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43616424
22DROSHA_22980978_ChIP-Seq_HELA_Human2.42627756
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.31449952
24ZNF263_19887448_ChIP-Seq_K562_Human2.28364131
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.22123816
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.17065358
27EZH2_27304074_Chip-Seq_ESCs_Mouse2.16231750
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.15814591
29ESR1_21235772_ChIP-Seq_MCF-7_Human2.15498190
30RACK7_27058665_Chip-Seq_MCF-7_Human2.12361579
31EZH2_27294783_Chip-Seq_ESCs_Mouse2.10240025
32SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05204147
33LXR_22292898_ChIP-Seq_THP-1_Human2.02265793
34RNF2_27304074_Chip-Seq_ESCs_Mouse2.01073480
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.99708819
36* REST_18959480_ChIP-ChIP_MESCs_Mouse1.99320067
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.88685418
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.73684485
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.72234297
40* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.70604207
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68829942
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.68041959
43NR3C1_23031785_ChIP-Seq_PC12_Mouse1.66267391
44ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.65153111
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.64744589
46RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.64594286
47ZNF274_21170338_ChIP-Seq_K562_Hela1.59186727
48RXR_22158963_ChIP-Seq_LIVER_Mouse1.54120293
49SMAD4_21799915_ChIP-Seq_A2780_Human1.53450240
50TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50938338
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.47997634
52TBX20_22080862_ChIP-Seq_HEART_Mouse1.47868662
53TBX20_22328084_ChIP-Seq_HEART_Mouse1.47868662
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45674566
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45325570
56NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.42116879
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41708034
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41232846
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.40566678
60SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39657995
61SOX9_24532713_ChIP-Seq_HFSC_Mouse1.38933796
62FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.38874271
63* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38318427
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34818085
65* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32457200
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31299527
67WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30669126
68WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30168367
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.29819681
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29695336
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29567579
72NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28282371
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27550812
74ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27430848
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26434445
76AR_21572438_ChIP-Seq_LNCaP_Human1.26417135
77SMC4_20622854_ChIP-Seq_HELA_Human1.25862504
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.25765653
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25689725
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25073171
81NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23947734
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22619627
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22591732
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21835598
85KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21578587
86SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20310332
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20273833
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20118149
89RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19284076
90PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18912897
91TP53_20018659_ChIP-ChIP_R1E_Mouse1.18131246
92FOXA2_19822575_ChIP-Seq_HepG2_Human1.18103525
93RING1B_27294783_Chip-Seq_ESCs_Mouse1.18061820
94TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17553085
95* AR_19668381_ChIP-Seq_PC3_Human1.17009724
96SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16726846
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16549499
98EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16145081
99KDM2B_26808549_Chip-Seq_K562_Human1.15981029
100NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15037684
101TP53_23651856_ChIP-Seq_MEFs_Mouse1.14814186
102RUNX1_27514584_Chip-Seq_MCF-7_Human1.14759172
103DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14680768
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12646871
105* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12639038
106CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12153761
107* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11997177
108SMAD3_21741376_ChIP-Seq_EPCs_Human1.11749576
109LXR_22158963_ChIP-Seq_LIVER_Mouse1.11301399
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10619645
111TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10098735
112TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09842035
113STAT3_23295773_ChIP-Seq_U87_Human1.09712984
114PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09114555
115SMAD3_21741376_ChIP-Seq_HESCs_Human1.08959086
116AR_25329375_ChIP-Seq_VCAP_Human1.08463356
117TP53_22127205_ChIP-Seq_IMR90_Human1.08088485
118ATF3_27146783_Chip-Seq_COLON_Human1.07229606
119SMC3_22415368_ChIP-Seq_MEFs_Mouse1.07026095
120P300_19829295_ChIP-Seq_ESCs_Human1.06756735
121TET1_21451524_ChIP-Seq_MESCs_Mouse1.06654672
122POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06588729
123TAF15_26573619_Chip-Seq_HEK293_Human1.06215874
124ARNT_22903824_ChIP-Seq_MCF-7_Human1.05775113
125PIAS1_25552417_ChIP-Seq_VCAP_Human1.04546210
126* CREB1_26743006_Chip-Seq_LNCaP_Human1.04426749
127AHR_22903824_ChIP-Seq_MCF-7_Human1.04300988
128CTCF_27219007_Chip-Seq_Bcells_Human1.03719739
129SOX2_20726797_ChIP-Seq_SW620_Human1.02754916
130YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02446549
131BCAT_22108803_ChIP-Seq_LS180_Human1.02114386
132TP53_16413492_ChIP-PET_HCT116_Human1.01897448
133RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01870697
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01404530
135ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01132071
136* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01043421
137SMAD4_21741376_ChIP-Seq_HESCs_Human0.99362562
138P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99234211
139ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98440183
140GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98315689
141BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97067298
142NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95919132
143OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95561675
144TCF4_23295773_ChIP-Seq_U87_Human0.94527101
145TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93784534
146GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.93004559
147RING1B_27294783_Chip-Seq_NPCs_Mouse0.92880784
148SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91200673
149VDR_22108803_ChIP-Seq_LS180_Human0.90163021
150RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90080422
151TET1_21490601_ChIP-Seq_MESCs_Mouse0.89768065
152RXR_22108803_ChIP-Seq_LS180_Human0.89521218
153MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88910919
154UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88542501
155* ESR2_21235772_ChIP-Seq_MCF-7_Human0.87542854
156ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87539760
157SMAD3_21741376_ChIP-Seq_ESCs_Human0.85934622
158* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85421821
159RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84518774
160TP53_18474530_ChIP-ChIP_U2OS_Human0.84489076
161PRDM14_20953172_ChIP-Seq_ESCs_Human0.84256389
162RUNX2_22187159_ChIP-Seq_PCA_Human0.83306027
163P53_22127205_ChIP-Seq_FIBROBLAST_Human0.82870435
164TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.81519159

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.60169015
2MP0002837_dystrophic_cardiac_calcinosis4.16186395
3MP0008438_abnormal_cutaneous_collagen4.01651456
4MP0003880_abnormal_central_pattern3.96092411
5MP0003635_abnormal_synaptic_transmissio3.42457589
6MP0004272_abnormal_basement_membrane3.20453945
7MP0003705_abnormal_hypodermis_morpholog3.07210806
8MP0000751_myopathy2.86609730
9MP0002822_catalepsy2.85450403
10* MP0004270_analgesia2.82526761
11* MP0002063_abnormal_learning/memory/cond2.75759362
12MP0009780_abnormal_chondrocyte_physiolo2.73945471
13* MP0009745_abnormal_behavioral_response2.61286266
14MP0002909_abnormal_adrenal_gland2.53922148
15MP0010368_abnormal_lymphatic_system2.52038110
16MP0003566_abnormal_cell_adhesion2.48584175
17MP0005257_abnormal_intraocular_pressure2.34402809
18MP0002064_seizures2.32800526
19MP0001958_emphysema2.24661906
20MP0001968_abnormal_touch/_nociception2.24115430
21MP0004145_abnormal_muscle_electrophysio2.20574034
22MP0010234_abnormal_vibrissa_follicle2.18891749
23* MP0002572_abnormal_emotion/affect_behav2.17780881
24MP0005623_abnormal_meninges_morphology2.11690088
25MP0003279_aneurysm2.11316367
26MP0004215_abnormal_myocardial_fiber2.10526328
27MP0003646_muscle_fatigue2.08664839
28MP0000013_abnormal_adipose_tissue2.01073183
29MP0002272_abnormal_nervous_system2.00590407
30MP0001501_abnormal_sleep_pattern1.98095101
31MP0004036_abnormal_muscle_relaxation1.97385100
32MP0002736_abnormal_nociception_after1.96187618
33MP0000749_muscle_degeneration1.94241443
34MP0004084_abnormal_cardiac_muscle1.89976307
35MP0002734_abnormal_mechanical_nocicepti1.88178955
36MP0003329_amyloid_beta_deposits1.85685733
37MP0010030_abnormal_orbit_morphology1.82332816
38MP0005503_abnormal_tendon_morphology1.81007289
39MP0002295_abnormal_pulmonary_circulatio1.79163829
40MP0003283_abnormal_digestive_organ1.75627181
41MP0001440_abnormal_grooming_behavior1.73740238
42MP0005409_darkened_coat_color1.72334794
43MP0005670_abnormal_white_adipose1.71125408
44MP0001486_abnormal_startle_reflex1.70596423
45MP0005058_abnormal_lysosome_morphology1.66832414
46MP0002733_abnormal_thermal_nociception1.65962771
47MP0009046_muscle_twitch1.63495563
48MP0004858_abnormal_nervous_system1.62737515
49MP0005275_abnormal_skin_tensile1.62278450
50MP0002735_abnormal_chemical_nociception1.61360961
51MP0001970_abnormal_pain_threshold1.57277688
52MP0000566_synostosis1.56288196
53MP0009384_cardiac_valve_regurgitation1.51470241
54MP0010386_abnormal_urinary_bladder1.48720089
55MP0005330_cardiomyopathy1.48268501
56MP0005646_abnormal_pituitary_gland1.47765078
57MP0005620_abnormal_muscle_contractility1.47753727
58MP0004484_altered_response_of1.46139769
59MP0002896_abnormal_bone_mineralization1.45089493
60MP0001299_abnormal_eye_distance/1.44652963
61MP0004085_abnormal_heartbeat1.43509624
62MP0000747_muscle_weakness1.42713801
63MP0004043_abnormal_pH_regulation1.38903871
64MP0002067_abnormal_sensory_capabilities1.38520444
65MP0002234_abnormal_pharynx_morphology1.36079472
66MP0008569_lethality_at_weaning1.34950211
67MP0004233_abnormal_muscle_weight1.34771311
68MP0004087_abnormal_muscle_fiber1.34751866
69MP0003123_paternal_imprinting1.34531430
70MP0001849_ear_inflammation1.34516965
71MP0003137_abnormal_impulse_conducting1.34468621
72MP0000767_abnormal_smooth_muscle1.32218623
73MP0003091_abnormal_cell_migration1.32018438
74MP0004510_myositis1.31198792
75MP0000462_abnormal_digestive_system1.31158189
76MP0005375_adipose_tissue_phenotype1.31067290
77MP0002972_abnormal_cardiac_muscle1.30206610
78MP0005423_abnormal_somatic_nervous1.28490998
79MP0002269_muscular_atrophy1.27977037
80MP0002106_abnormal_muscle_physiology1.27939082
81MP0002184_abnormal_innervation1.27213082
82MP0008961_abnormal_basal_metabolism1.25007951
83MP0003879_abnormal_hair_cell1.23586898
84MP0004811_abnormal_neuron_physiology1.22706269
85MP0002060_abnormal_skin_morphology1.21105908
86MP0004130_abnormal_muscle_cell1.19862314
87MP0009840_abnormal_foam_cell1.18677997
88MP0002557_abnormal_social/conspecific_i1.17700313
89MP0003941_abnormal_skin_development1.17317809
90MP0003942_abnormal_urinary_system1.17060615
91MP0005508_abnormal_skeleton_morphology1.17026901
92* MP0005386_behavior/neurological_phenoty1.15588314
93* MP0004924_abnormal_behavior1.15588314
94MP0000759_abnormal_skeletal_muscle1.14821707
95MP0001502_abnormal_circadian_rhythm1.12903857
96MP0000955_abnormal_spinal_cord1.12604703
97MP0000534_abnormal_ureter_morphology1.11636592
98MP0003633_abnormal_nervous_system1.10662421
99MP0005369_muscle_phenotype1.10082161
100MP0001984_abnormal_olfaction1.09831890
101MP0002089_abnormal_postnatal_growth/wei1.09271641
102MP0006276_abnormal_autonomic_nervous1.09064592
103* MP0002066_abnormal_motor_capabilities/c1.08354551
104MP0005535_abnormal_body_temperature1.07768953
105MP0002108_abnormal_muscle_morphology1.07262986
106MP0002254_reproductive_system_inflammat1.04312960
107MP0004782_abnormal_surfactant_physiolog1.00223607
108MP0002882_abnormal_neuron_morphology0.99439756
109MP0000778_abnormal_nervous_system0.98462007
110MP0005023_abnormal_wound_healing0.98143377
111MP0002877_abnormal_melanocyte_morpholog0.97810239
112MP0003172_abnormal_lysosome_physiology0.97725902
113MP0002249_abnormal_larynx_morphology0.96749184
114MP0010329_abnormal_lipoprotein_level0.94802112
115MP0000762_abnormal_tongue_morphology0.93948374
116MP0000750_abnormal_muscle_regeneration0.92414218
117MP0006138_congestive_heart_failure0.91976281
118MP0001765_abnormal_ion_homeostasis0.90831463
119MP0000003_abnormal_adipose_tissue0.90821503
120* MP0002693_abnormal_pancreas_physiology0.88186561
121MP0003122_maternal_imprinting0.87263222
122MP0004885_abnormal_endolymph0.85871987
123MP0003950_abnormal_plasma_membrane0.85694061
124MP0005666_abnormal_adipose_tissue0.85547411
125MP0005595_abnormal_vascular_smooth0.85514581
126MP0001661_extended_life_span0.85243047
127MP0005645_abnormal_hypothalamus_physiol0.83415780
128MP0003075_altered_response_to0.82599793
129MP0003787_abnormal_imprinting0.82448534
130MP0001879_abnormal_lymphatic_vessel0.80588318
131MP0003631_nervous_system_phenotype0.80584358
132* MP0002078_abnormal_glucose_homeostasis0.80462567
133MP0000678_abnormal_parathyroid_gland0.80374168
134MP0002796_impaired_skin_barrier0.79972453
135MP0008874_decreased_physiological_sensi0.78044992
136MP0005385_cardiovascular_system_phenoty0.76997182
137MP0001544_abnormal_cardiovascular_syste0.76997182
138MP0002229_neurodegeneration0.76781786
139MP0001542_abnormal_bone_strength0.76679796
140* MP0002069_abnormal_eating/drinking_beha0.76126930
141MP0005165_increased_susceptibility_to0.73590023
142MP0000604_amyloidosis0.73418693
143MP0002971_abnormal_brown_adipose0.73218173
144MP0003115_abnormal_respiratory_system0.71717901
145MP0003634_abnormal_glial_cell0.71439374
146* MP0001944_abnormal_pancreas_morphology0.71089330
147MP0001756_abnormal_urination0.70181416
148MP0006072_abnormal_retinal_apoptosis0.69949246
149MP0001905_abnormal_dopamine_level0.69899558
150MP0005187_abnormal_penis_morphology0.69847707
151MP0002152_abnormal_brain_morphology0.67848894
152MP0002876_abnormal_thyroid_physiology0.67762133
153MP0005076_abnormal_cell_differentiation0.67138604
154MP0003453_abnormal_keratinocyte_physiol0.66656909
155MP0008775_abnormal_heart_ventricle0.65641543
156MP0010630_abnormal_cardiac_muscle0.64997916
157MP0004133_heterotaxia0.64129690
158MP0000163_abnormal_cartilage_morphology0.63828963
159MP0009672_abnormal_birth_weight0.63788639
160MP0004019_abnormal_vitamin_homeostasis0.63372804
161MP0000733_abnormal_muscle_development0.60900099
162MP0000467_abnormal_esophagus_morphology0.59624080
163MP0001614_abnormal_blood_vessel0.59568790
164MP0001915_intracranial_hemorrhage0.59039636
165MP0002116_abnormal_craniofacial_bone0.58814463
166MP0002168_other_aberrant_phenotype0.58621504
167MP0001243_abnormal_dermal_layer0.58615928
168MP0002128_abnormal_blood_circulation0.58060426

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.84985267
2Myokymia (HP:0002411)5.00819412
3Premature rupture of membranes (HP:0001788)4.95329694
4Protrusio acetabuli (HP:0003179)4.92068858
5Visual hallucinations (HP:0002367)4.32432671
6Sudden death (HP:0001699)4.27477027
7Focal seizures (HP:0007359)4.14417813
8Exercise-induced myalgia (HP:0003738)3.86188359
9Calf muscle hypertrophy (HP:0008981)3.83954287
10Muscle hypertrophy of the lower extremities (HP:0008968)3.61705718
11Epileptic encephalopathy (HP:0200134)3.26855465
12Abnormality of the calf musculature (HP:0001430)3.25555669
13Vertebral compression fractures (HP:0002953)3.22856471
14Absence seizures (HP:0002121)3.18465905
15Syncope (HP:0001279)3.17222503
16Bundle branch block (HP:0011710)3.15845181
17Atonic seizures (HP:0010819)3.12151188
18Cervical subluxation (HP:0003308)3.09900368
19Generalized tonic-clonic seizures (HP:0002069)3.06948543
20Prolonged QT interval (HP:0001657)3.04102154
21Vascular tortuosity (HP:0004948)3.03993580
22Ventricular fibrillation (HP:0001663)2.97193835
23Exercise-induced muscle cramps (HP:0003710)2.96879037
24Supranuclear gaze palsy (HP:0000605)2.95964377
25Cerebral inclusion bodies (HP:0100314)2.95892659
26Dialeptic seizures (HP:0011146)2.93715591
27Primary atrial arrhythmia (HP:0001692)2.88270018
28Arterial tortuosity (HP:0005116)2.86918388
29Abnormality of dentin (HP:0010299)2.85267713
30Hyperventilation (HP:0002883)2.84895057
31Atrial fibrillation (HP:0005110)2.82306585
32Depression (HP:0000716)2.78523717
33Mitral stenosis (HP:0001718)2.78326549
34Shallow orbits (HP:0000586)2.77243506
35Distal upper limb amyotrophy (HP:0007149)2.74066654
36Upper limb amyotrophy (HP:0009129)2.74066654
37Cerebral aneurysm (HP:0004944)2.73840596
38Spinal rigidity (HP:0003306)2.73724354
39Ankle contracture (HP:0006466)2.73371473
40Supraventricular tachycardia (HP:0004755)2.71801692
41Abnormal EKG (HP:0003115)2.70802642
42Cardiovascular calcification (HP:0011915)2.69615200
43Distal lower limb muscle weakness (HP:0009053)2.69428080
44Hyporeflexia of lower limbs (HP:0002600)2.68764786
45EMG: myopathic abnormalities (HP:0003458)2.68174301
46Neurofibrillary tangles (HP:0002185)2.66354244
47Supraventricular arrhythmia (HP:0005115)2.65812251
48Vascular calcification (HP:0004934)2.64460851
49Action tremor (HP:0002345)2.63923659
50Myotonia (HP:0002486)2.57262581
51Muscle fiber splitting (HP:0003555)2.56713933
52Hyperinsulinemic hypoglycemia (HP:0000825)2.56214921
53Short nail (HP:0001799)2.56048148
54Febrile seizures (HP:0002373)2.56036533
55* Anxiety (HP:0000739)2.54327106
56Epileptiform EEG discharges (HP:0011182)2.53999452
57Poor eye contact (HP:0000817)2.52268220
58Amblyopia (HP:0000646)2.49482991
59Aortic dissection (HP:0002647)2.48783832
60Broad metatarsal (HP:0001783)2.46095762
61Difficulty running (HP:0009046)2.45977987
62Impaired social interactions (HP:0000735)2.45155591
63Abnormal social behavior (HP:0012433)2.45155591
64Pheochromocytoma (HP:0002666)2.43437187
65Ventricular arrhythmia (HP:0004308)2.42284975
66Obstructive sleep apnea (HP:0002870)2.41360644
67Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.39447835
68Rapidly progressive (HP:0003678)2.38242396
69Broad-based gait (HP:0002136)2.37675381
70Asymmetric septal hypertrophy (HP:0001670)2.37057428
71Wormian bones (HP:0002645)2.35647358
72Ketoacidosis (HP:0001993)2.34585353
73Dysmetria (HP:0001310)2.32873898
74Bladder diverticulum (HP:0000015)2.32871931
75Aortic aneurysm (HP:0004942)2.32125710
76Heart block (HP:0012722)2.31326044
77Fetal akinesia sequence (HP:0001989)2.30691565
78Myoglobinuria (HP:0002913)2.30507810
79EEG with generalized epileptiform discharges (HP:0011198)2.30469845
80Impaired vibration sensation in the lower limbs (HP:0002166)2.30443692
81Hand muscle atrophy (HP:0009130)2.27977223
82Progressive cerebellar ataxia (HP:0002073)2.27768037
83Dysdiadochokinesis (HP:0002075)2.26812001
84Atrophic scars (HP:0001075)2.26522264
85Truncal ataxia (HP:0002078)2.26452243
86Bronchomalacia (HP:0002780)2.26392242
87Increased connective tissue (HP:0009025)2.25824887
88Right ventricular cardiomyopathy (HP:0011663)2.23675020
89Global brain atrophy (HP:0002283)2.22730367
90Increased variability in muscle fiber diameter (HP:0003557)2.22468698
91Stridor (HP:0010307)2.21373257
92Lower limb amyotrophy (HP:0007210)2.20056176
93Hypsarrhythmia (HP:0002521)2.19691420
94Difficulty climbing stairs (HP:0003551)2.19490527
95Ulnar bowing (HP:0003031)2.17783917
96Fragile skin (HP:0001030)2.17197455
97Type 1 muscle fiber predominance (HP:0003803)2.16859863
98Postural instability (HP:0002172)2.16723410
99Abnormal atrioventricular conduction (HP:0005150)2.16210746
100Neuroendocrine neoplasm (HP:0100634)2.15319771
101Ventricular tachycardia (HP:0004756)2.15229467
102Atrioventricular block (HP:0001678)2.14548913
103Resting tremor (HP:0002322)2.09804862
104Mildly elevated creatine phosphokinase (HP:0008180)2.08624391
105Distal lower limb amyotrophy (HP:0008944)2.08317709
106J-shaped sella turcica (HP:0002680)2.07555923
107Decreased circulating renin level (HP:0003351)2.06932896
108Lymphangioma (HP:0100764)2.06639614
109Hyperacusis (HP:0010780)2.06076860
110Subaortic stenosis (HP:0001682)2.05902692
111Abnormality of the left ventricular outflow tract (HP:0011103)2.05902692
112Long toe (HP:0010511)2.05878812
113Dysmetric saccades (HP:0000641)2.05800871
114Skin nodule (HP:0200036)2.05489985
115Urinary glycosaminoglycan excretion (HP:0003541)2.05234121
116Mucopolysacchariduria (HP:0008155)2.05234121
117Aneurysm (HP:0002617)2.02529912
118Neonatal short-limb short stature (HP:0008921)2.00426923
119Abnormality of mucopolysaccharide metabolism (HP:0011020)1.96778614
120Abnormality of polysaccharide metabolism (HP:0011012)1.96778614
121Abnormality of glycosaminoglycan metabolism (HP:0004371)1.96778614
122Papilledema (HP:0001085)1.96578760
123Advanced eruption of teeth (HP:0006288)1.95760945
124Drooling (HP:0002307)1.95571897
125Excessive salivation (HP:0003781)1.95571897
126Atelectasis (HP:0100750)1.94692699
127Abnormality of skeletal muscle fiber size (HP:0012084)1.94550438
128Palpitations (HP:0001962)1.93901270
129Broad face (HP:0000283)1.93488963
130Urinary bladder sphincter dysfunction (HP:0002839)1.93461603
131Hypoglycemic seizures (HP:0002173)1.91164613
132Mitral regurgitation (HP:0001653)1.90819130
133Back pain (HP:0003418)1.90505788
134Turricephaly (HP:0000262)1.90416965
135Spinal cord compression (HP:0002176)1.89857967
136Hemiparesis (HP:0001269)1.89420990
137Abnormality of the lower motor neuron (HP:0002366)1.88881019
138Soft skin (HP:0000977)1.88779047
139Xanthomatosis (HP:0000991)1.88194629
140Blue sclerae (HP:0000592)1.88096631
141Large for gestational age (HP:0001520)1.87907012
142Left ventricular hypertrophy (HP:0001712)1.86920527
143Type II lissencephaly (HP:0007260)1.86574919
144Bradykinesia (HP:0002067)1.85505136
145Hyperkalemia (HP:0002153)1.85479493
146Congenital glaucoma (HP:0001087)1.85379063
147Muscle fiber inclusion bodies (HP:0100299)1.84160911
148Athetosis (HP:0002305)1.83774076
149Hypokinesia (HP:0002375)1.82319539
150Diplopia (HP:0000651)1.82123527
151Abnormality of binocular vision (HP:0011514)1.82123527
152EMG: neuropathic changes (HP:0003445)1.81673881
153Deep venous thrombosis (HP:0002625)1.81349958
154Generalized amyotrophy (HP:0003700)1.80779016
155Impaired smooth pursuit (HP:0007772)1.80576076
156Termporal pattern (HP:0011008)1.80362409
157Insidious onset (HP:0003587)1.80362409
158Hyperextensible skin (HP:0000974)1.79353142
159Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.78202524
160Hyperparathyroidism (HP:0000843)1.77436788
161Aplasia of the phalanges of the hand (HP:0009802)1.76348642
162Aplasia involving bones of the extremities (HP:0009825)1.76348642
163Aplasia involving bones of the upper limbs (HP:0009823)1.76348642
164Asymmetry of the thorax (HP:0001555)1.76120074
165Neonatal death (HP:0003811)1.75213786
166Hypoglycemic coma (HP:0001325)1.75003041
167Abnormality of the Achilles tendon (HP:0005109)1.74672305
168Acanthosis nigricans (HP:0000956)1.74250580
169Bradycardia (HP:0001662)1.73096219
170Hypoventilation (HP:0002791)1.72361401
171Follicular hyperkeratosis (HP:0007502)1.72272039
172Enlarged penis (HP:0000040)1.71885289
173Coronal craniosynostosis (HP:0004440)1.71723342
174Insulin resistance (HP:0000855)1.71055274
175Achilles tendon contracture (HP:0001771)1.70410390
176Mitral valve prolapse (HP:0001634)1.66390645
177Growth hormone excess (HP:0000845)1.65956581
178Bowel diverticulosis (HP:0005222)1.65744706
179Abnormality of carpal bone ossification (HP:0006257)1.65576631
180Abnormality of aromatic amino acid family metabolism (HP:0004338)1.62710400
181Natal tooth (HP:0000695)1.62610959
182Elbow flexion contracture (HP:0002987)1.61718337
183Coxa vara (HP:0002812)1.61707649
184Biconcave vertebral bodies (HP:0004586)1.61441527
185Abnormality of the acetabulum (HP:0003170)1.61398834

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.67681935
2NTRK34.48322932
3EPHA23.55419614
4RIPK43.44916683
5MAP3K93.11126711
6SIK12.98331535
7TESK12.76585671
8PRKD32.61351463
9EEF2K2.45860974
10KSR22.33393578
11MAPKAPK32.30621898
12NTRK12.12681435
13MAP3K42.12362350
14MINK12.05775402
15MET1.99683303
16ERN11.88774166
17ARAF1.85063443
18FGFR41.85033321
19ICK1.74608547
20LIMK11.71608309
21BMPR21.68459905
22PAK41.64006852
23PAK61.63406974
24PKN21.61831572
25PHKG11.61272785
26PHKG21.61272785
27SMG11.57149546
28MAP2K41.55345949
29DAPK21.51934303
30MAP2K71.50960201
31MAP3K131.49466070
32DMPK1.49196449
33MST1R1.44136571
34TIE11.43882751
35CAMKK11.43416803
36MAP3K21.42242571
37KSR11.38794289
38STK381.36225487
39INSRR1.34200166
40CDK51.33862189
41PINK11.33213793
42DAPK11.30532681
43PTK2B1.30438759
44TRPM71.29271914
45TTN1.28358292
46DDR21.26698962
47GRK51.25724826
48NME11.24097494
49LMTK21.23712912
50CAMK2A1.22563348
51EPHB21.21019702
52OBSCN1.18968958
53EPHB11.18633776
54CAMK2B1.17958309
55PAK31.14877003
56MAP3K11.12194070
57TRIB31.09835550
58MARK11.09176881
59RPS6KA21.07848697
60MUSK1.07122455
61PLK21.06157572
62MAPK151.04697707
63NTRK21.04307064
64MAP3K121.03832466
65MTOR1.02151794
66CAMK2D1.01992855
67PRKCG1.00424364
68PNCK0.94692111
69RAF10.94573989
70CDK120.91757182
71PRKCH0.91376305
72FER0.91185321
73MAP3K70.90482630
74FES0.89475690
75CAMKK20.88451009
76PDGFRA0.84171392
77SIK20.83560564
78PAK20.83469721
79FGFR20.83162064
80PRKG20.82579417
81CDC42BPA0.81892987
82RET0.81732991
83LATS20.81096144
84MAP2K10.81018799
85TYRO30.77749443
86ROCK10.76749153
87UHMK10.75588135
88PTK60.74783303
89IRAK30.74414618
90FGFR30.73735869
91SGK10.73598569
92MOS0.68252159
93SCYL20.68225812
94PDPK10.66535336
95PRKCE0.65967266
96GRK70.65099271
97PDK30.65094641
98PDK40.65094641
99WNK40.64812695
100CAMK10.64246332
101CAMK2G0.62265484
102PRPF4B0.62247724
103TAOK10.61950882
104PRKD20.60470518
105CDK80.59484135
106ERBB40.58867070
107MARK20.58540907
108PDK10.58326490
109SGK2230.57551044
110SGK4940.57551044
111CAMK1G0.56720594
112CDK140.56612107
113AKT20.55646187
114NEK10.54477426
115CDK180.54252779
116TNIK0.54183395
117STK110.53843137
118BRAF0.53405020
119CDK150.53235409
120DAPK30.53046939
121PRKAA20.52412012
122ABL20.52287697
123PRKAA10.52045481
124SGK30.51613670
125WNK10.51453256
126MYLK0.51267077
127RIPK10.51239735
128ILK0.50984928
129PRKD10.50291178
130SGK20.50070723
131PDGFRB0.49840578
132HIPK20.49636694
133TGFBR20.48622220
134RPS6KA30.47706352
135CASK0.46122716
136RPS6KB20.45517248
137LATS10.44204117
138CDK90.42680627
139MAP3K30.42637486
140CDK11A0.42587672
141MAPK100.42203765
142BRSK10.41611705
143PRKACA0.41428650
144FGR0.41255420
145PTK20.40359576
146CAMK1D0.39735349
147MAP2K60.39378390
148NEK90.39338964
149AKT30.39301116
150GSK3A0.38399126
151ROCK20.37943127

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.93347092
2Long-term potentiation_Homo sapiens_hsa047202.84299560
3Amphetamine addiction_Homo sapiens_hsa050312.57611147
4Circadian entrainment_Homo sapiens_hsa047132.50682519
5Insulin secretion_Homo sapiens_hsa049112.34180118
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.26980087
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.25962451
8GABAergic synapse_Homo sapiens_hsa047272.18767285
9Glutamatergic synapse_Homo sapiens_hsa047242.17731766
10Olfactory transduction_Homo sapiens_hsa047402.15882432
11Synaptic vesicle cycle_Homo sapiens_hsa047212.11968630
12Morphine addiction_Homo sapiens_hsa050322.06898872
13Salivary secretion_Homo sapiens_hsa049702.06566018
14Dopaminergic synapse_Homo sapiens_hsa047282.00818285
15ECM-receptor interaction_Homo sapiens_hsa045121.89886734
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.89843354
17Renin secretion_Homo sapiens_hsa049241.86833174
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.85399080
19Vitamin B6 metabolism_Homo sapiens_hsa007501.85059403
20Gastric acid secretion_Homo sapiens_hsa049711.83439443
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.82237846
22Cardiac muscle contraction_Homo sapiens_hsa042601.79869656
23Taste transduction_Homo sapiens_hsa047421.79165681
24Phenylalanine metabolism_Homo sapiens_hsa003601.71198701
25Calcium signaling pathway_Homo sapiens_hsa040201.70851800
26Cocaine addiction_Homo sapiens_hsa050301.68932334
27Cholinergic synapse_Homo sapiens_hsa047251.68499211
28Oxytocin signaling pathway_Homo sapiens_hsa049211.64641352
29Dilated cardiomyopathy_Homo sapiens_hsa054141.61400694
30Other glycan degradation_Homo sapiens_hsa005111.61078679
31Serotonergic synapse_Homo sapiens_hsa047261.49407505
32Long-term depression_Homo sapiens_hsa047301.49393531
33Focal adhesion_Homo sapiens_hsa045101.44573735
34GnRH signaling pathway_Homo sapiens_hsa049121.40753280
35Type II diabetes mellitus_Homo sapiens_hsa049301.37925671
36* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35769866
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34850754
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33497761
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.29540218
40cAMP signaling pathway_Homo sapiens_hsa040241.29477301
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29295923
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.27360695
43Gap junction_Homo sapiens_hsa045401.26241977
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.25285134
45Collecting duct acid secretion_Homo sapiens_hsa049661.20430954
46Pancreatic secretion_Homo sapiens_hsa049721.15323428
47Vascular smooth muscle contraction_Homo sapiens_hsa042701.13042561
48Alzheimers disease_Homo sapiens_hsa050101.11253270
49Fatty acid elongation_Homo sapiens_hsa000621.10497829
50Glucagon signaling pathway_Homo sapiens_hsa049221.10438614
51PPAR signaling pathway_Homo sapiens_hsa033201.10436136
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.10095169
53Arginine biosynthesis_Homo sapiens_hsa002201.10027500
54Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09896039
55Estrogen signaling pathway_Homo sapiens_hsa049151.09796356
56Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.07550450
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06844015
58Glioma_Homo sapiens_hsa052141.05199584
59Vibrio cholerae infection_Homo sapiens_hsa051101.05114477
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04196756
61Arginine and proline metabolism_Homo sapiens_hsa003301.03966379
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03047296
63Galactose metabolism_Homo sapiens_hsa000521.02796888
64Melanogenesis_Homo sapiens_hsa049161.01106816
65Adherens junction_Homo sapiens_hsa045201.00868155
66Tyrosine metabolism_Homo sapiens_hsa003501.00399637
67Histidine metabolism_Homo sapiens_hsa003400.96504334
68Complement and coagulation cascades_Homo sapiens_hsa046100.96214468
69Folate biosynthesis_Homo sapiens_hsa007900.95378616
70Hippo signaling pathway_Homo sapiens_hsa043900.95132641
71Thyroid hormone synthesis_Homo sapiens_hsa049180.95099616
72N-Glycan biosynthesis_Homo sapiens_hsa005100.92877917
73Proteoglycans in cancer_Homo sapiens_hsa052050.92631976
74Fatty acid metabolism_Homo sapiens_hsa012120.91017902
75Protein digestion and absorption_Homo sapiens_hsa049740.89088074
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85476175
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85405529
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.84711276
79Lysosome_Homo sapiens_hsa041420.84359023
80VEGF signaling pathway_Homo sapiens_hsa043700.82473517
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82376300
82Fructose and mannose metabolism_Homo sapiens_hsa000510.82004758
83Oxidative phosphorylation_Homo sapiens_hsa001900.81694837
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81303176
85beta-Alanine metabolism_Homo sapiens_hsa004100.81005735
86Dorso-ventral axis formation_Homo sapiens_hsa043200.80810102
87Sphingolipid metabolism_Homo sapiens_hsa006000.80049255
88Basal cell carcinoma_Homo sapiens_hsa052170.78257830
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78184978
90Notch signaling pathway_Homo sapiens_hsa043300.76321271
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76151487
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75559672
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75060333
94Pentose phosphate pathway_Homo sapiens_hsa000300.72186472
95Carbon metabolism_Homo sapiens_hsa012000.71620472
96Parkinsons disease_Homo sapiens_hsa050120.71260568
97Axon guidance_Homo sapiens_hsa043600.70449772
98Fatty acid biosynthesis_Homo sapiens_hsa000610.70409057
99Glutathione metabolism_Homo sapiens_hsa004800.69881249
100Amoebiasis_Homo sapiens_hsa051460.69624307
101Fatty acid degradation_Homo sapiens_hsa000710.68416784
102ErbB signaling pathway_Homo sapiens_hsa040120.67229692
103Biosynthesis of amino acids_Homo sapiens_hsa012300.66816217
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65328130
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64582002
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64003158
107Insulin signaling pathway_Homo sapiens_hsa049100.63207342
108Choline metabolism in cancer_Homo sapiens_hsa052310.63148811
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.62873346
110Pyruvate metabolism_Homo sapiens_hsa006200.62730426
111Phototransduction_Homo sapiens_hsa047440.61673253
112mTOR signaling pathway_Homo sapiens_hsa041500.61239238
113Oocyte meiosis_Homo sapiens_hsa041140.60956564
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60562075
115Hedgehog signaling pathway_Homo sapiens_hsa043400.60092807
116Circadian rhythm_Homo sapiens_hsa047100.57891518
117MAPK signaling pathway_Homo sapiens_hsa040100.57218582
118Sulfur relay system_Homo sapiens_hsa041220.57212994
119Steroid biosynthesis_Homo sapiens_hsa001000.55552598
120Sulfur metabolism_Homo sapiens_hsa009200.53712917
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53634084
122Cyanoamino acid metabolism_Homo sapiens_hsa004600.53371716
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53135493
124Thyroid cancer_Homo sapiens_hsa052160.53111234
125Type I diabetes mellitus_Homo sapiens_hsa049400.52223229
126Prion diseases_Homo sapiens_hsa050200.51352582
127Rap1 signaling pathway_Homo sapiens_hsa040150.49428685
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47936371
129Ras signaling pathway_Homo sapiens_hsa040140.46489768
130Bile secretion_Homo sapiens_hsa049760.45516212
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.45258952
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43910875
133Inositol phosphate metabolism_Homo sapiens_hsa005620.43429427
1342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42945963
135Huntingtons disease_Homo sapiens_hsa050160.41963194
136Insulin resistance_Homo sapiens_hsa049310.41874326
137Nitrogen metabolism_Homo sapiens_hsa009100.40093951
138Non-small cell lung cancer_Homo sapiens_hsa052230.37597537
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35824105
140African trypanosomiasis_Homo sapiens_hsa051430.34446020
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.33178006
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31695696
143Renal cell carcinoma_Homo sapiens_hsa052110.31086754
144Mineral absorption_Homo sapiens_hsa049780.28962554
145Endocytosis_Homo sapiens_hsa041440.28056220
146Wnt signaling pathway_Homo sapiens_hsa043100.27875534
147Ovarian steroidogenesis_Homo sapiens_hsa049130.27824635
148AMPK signaling pathway_Homo sapiens_hsa041520.27143503
149Tight junction_Homo sapiens_hsa045300.26999094
150Adipocytokine signaling pathway_Homo sapiens_hsa049200.26626059
151Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25832215

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