WFDC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)9.53943220
2left/right pattern formation (GO:0060972)8.69748001
3vitamin transmembrane transport (GO:0035461)7.26491634
4regulation of cilium movement (GO:0003352)6.90702351
5response to xenobiotic stimulus (GO:0009410)6.41054073
6left/right axis specification (GO:0070986)6.17526784
7ethanol oxidation (GO:0006069)6.01448110
8microtubule bundle formation (GO:0001578)6.01249108
9one-carbon compound transport (GO:0019755)5.99073388
10ventricular system development (GO:0021591)5.98315669
11pyrimidine-containing compound transmembrane transport (GO:0072531)5.98299652
12terpenoid biosynthetic process (GO:0016114)5.93841080
13intraciliary transport (GO:0042073)5.84402258
14lung lobe morphogenesis (GO:0060463)5.82829928
15cilium organization (GO:0044782)5.40039177
16retinoic acid metabolic process (GO:0042573)5.39912672
17hemidesmosome assembly (GO:0031581)5.32593609
18cilium assembly (GO:0042384)5.24723407
19L-ascorbic acid metabolic process (GO:0019852)5.24099713
20positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003605.05067977
21negative regulation of T cell differentiation in thymus (GO:0033085)4.93253590
22interferon-gamma secretion (GO:0072643)4.92048814
23centriole assembly (GO:0098534)4.90194751
24tolerance induction (GO:0002507)4.89922688
25ethanol metabolic process (GO:0006067)4.82155411
26sperm capacitation (GO:0048240)4.75637469
27establishment of apical/basal cell polarity (GO:0035089)4.56723945
28negative regulation of humoral immune response (GO:0002921)4.45628736
29negative regulation of B cell mediated immunity (GO:0002713)4.44506336
30negative regulation of immunoglobulin mediated immune response (GO:0002890)4.44506336
31protein localization to cilium (GO:0061512)4.42826407
32dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.40980872
33mesodermal cell differentiation (GO:0048333)4.40943729
34multicellular organismal water homeostasis (GO:0050891)4.34645075
35positive regulation of endothelial cell differentiation (GO:0045603)4.30416364
36retinol metabolic process (GO:0042572)4.24685575
37regulation of interleukin-5 production (GO:0032674)4.20350533
38primary alcohol catabolic process (GO:0034310)4.17280864
39microtubule-based movement (GO:0007018)4.15822207
40cellular component assembly involved in morphogenesis (GO:0010927)4.14531488
41epithelial tube branching involved in lung morphogenesis (GO:0060441)4.14314756
42epithelial cell differentiation involved in prostate gland development (GO:0060742)4.12566205
43xenobiotic catabolic process (GO:0042178)4.09736034
44lung vasculature development (GO:0060426)4.07161656
45regulation of microtubule-based movement (GO:0060632)4.03108721
46regulation of toll-like receptor 4 signaling pathway (GO:0034143)4.02469368
47primary alcohol metabolic process (GO:0034308)4.01930882
48pattern specification involved in kidney development (GO:0061004)4.00778343
49regulation of germinal center formation (GO:0002634)3.98107682
50positive regulation of tolerance induction (GO:0002645)3.97322052
51respiratory tube development (GO:0030323)3.94118389
52morphogenesis of an endothelium (GO:0003159)3.92902268
53endothelial tube morphogenesis (GO:0061154)3.92902268
54calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.92281866
55cell projection assembly (GO:0030031)3.90320891
56gas transport (GO:0015669)3.89544711
57glutathione derivative metabolic process (GO:1901685)3.89228244
58glutathione derivative biosynthetic process (GO:1901687)3.89228244
59cilium morphogenesis (GO:0060271)3.82094776
60establishment or maintenance of monopolar cell polarity (GO:0061339)3.79440684
61establishment of monopolar cell polarity (GO:0061162)3.79440684
62renal absorption (GO:0070293)3.77327889
63regulation of hippo signaling (GO:0035330)3.76457834
64establishment of planar polarity (GO:0001736)3.74027531
65establishment of tissue polarity (GO:0007164)3.74027531
66sodium ion homeostasis (GO:0055078)3.72898316
67tight junction assembly (GO:0070830)3.71670174
68cytoplasmic microtubule organization (GO:0031122)3.71480510
69water homeostasis (GO:0030104)3.69337673
70peptide catabolic process (GO:0043171)3.66605133
71cellular response to nitric oxide (GO:0071732)3.62884585
72cell adhesion mediated by integrin (GO:0033627)3.62503272
73cellular copper ion homeostasis (GO:0006878)3.58990665
74nucleoside diphosphate phosphorylation (GO:0006165)3.56865128
75regulation of endothelial cell differentiation (GO:0045601)3.51587483
76excretion (GO:0007588)3.50927704
77response to nitrosative stress (GO:0051409)3.48172896
78progesterone metabolic process (GO:0042448)3.44439895
79hypotonic response (GO:0006971)3.41335635
80microtubule depolymerization (GO:0007019)3.39155407
81oligosaccharide biosynthetic process (GO:0009312)3.37719750
82embryonic foregut morphogenesis (GO:0048617)3.36121620
83bundle of His cell to Purkinje myocyte communication (GO:0086069)3.35252130
84exogenous drug catabolic process (GO:0042738)3.31516235
85microtubule polymerization or depolymerization (GO:0031109)3.27235771
86hepatocyte apoptotic process (GO:0097284)3.22528376
87lung-associated mesenchyme development (GO:0060484)3.19994707
88branching involved in salivary gland morphogenesis (GO:0060445)3.18476425
89negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.18065408
90intestinal epithelial cell development (GO:0060576)3.14596399
91phosphate ion transmembrane transport (GO:0035435)3.13763974
92lung alveolus development (GO:0048286)3.13100798
93negative regulation of inclusion body assembly (GO:0090084)3.10257167
94phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.08719857
95hydrogen peroxide biosynthetic process (GO:0050665)3.08241928
96glomerular epithelial cell development (GO:0072310)3.05560481
97lymphangiogenesis (GO:0001946)3.04027960
98positive regulation of smoothened signaling pathway (GO:0045880)3.03987588
99ear development (GO:0043583)3.03833525
100diterpenoid biosynthetic process (GO:0016102)3.03597515
101apical protein localization (GO:0045176)3.03434650
102hydrogen peroxide catabolic process (GO:0042744)3.02613342
103lateral sprouting from an epithelium (GO:0060601)3.01432272
104lung epithelium development (GO:0060428)3.01124852
105axonemal dynein complex assembly (GO:0070286)20.6554964
106negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.99852583
107regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.98262968
108negative regulation of cell fate specification (GO:0009996)2.95383797
109regulation of microtubule depolymerization (GO:0031114)2.94801326
110protein O-linked glycosylation (GO:0006493)2.94735537
111mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.91913450
112hormone catabolic process (GO:0042447)2.91845817
113regulation of tolerance induction (GO:0002643)2.90583351
114epithelial cell-cell adhesion (GO:0090136)2.90481283
115positive regulation of osteoblast proliferation (GO:0033690)2.90433975
116regulation of glomerular filtration (GO:0003093)2.89643788
117aldehyde catabolic process (GO:0046185)2.89103051
118cellular response to reactive nitrogen species (GO:1902170)2.88244491
119lateral ventricle development (GO:0021670)2.88213498
120regulation of interleukin-13 production (GO:0032656)2.86916240
121phosphate ion transport (GO:0006817)2.84990328
122sodium-independent organic anion transport (GO:0043252)2.84436244
123negative regulation of epidermal cell differentiation (GO:0045605)2.82263421
124renal system development (GO:0072001)2.80828078
125polarized epithelial cell differentiation (GO:0030859)2.80003103
126regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.78992892
127regulation of integrin-mediated signaling pathway (GO:2001044)2.76948220
128establishment or maintenance of bipolar cell polarity (GO:0061245)2.76071636
129establishment or maintenance of apical/basal cell polarity (GO:0035088)2.76071636
130copper ion transport (GO:0006825)2.75159421
131response to nitric oxide (GO:0071731)2.73832348
132regulation of cardioblast differentiation (GO:0051890)2.73345370
133regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.73137335
134regulation of autophagic vacuole assembly (GO:2000785)2.72181857
135polyol transport (GO:0015791)2.71606731
136embryonic camera-type eye development (GO:0031076)2.71496797
137reactive oxygen species biosynthetic process (GO:1903409)2.70613141
138renal system process involved in regulation of blood volume (GO:0001977)2.69815794
139glial cell proliferation (GO:0014009)2.68516428
140renal filtration (GO:0097205)2.68085308
141carnitine metabolic process (GO:0009437)2.68023684
142regulation of cardioblast proliferation (GO:0003264)2.67692533
143regulation of secondary heart field cardioblast proliferation (GO:0003266)2.67692533
144transepithelial transport (GO:0070633)2.67533401
145regulation of vasculogenesis (GO:2001212)2.67518254
146copper ion homeostasis (GO:0055070)2.67293893
147membrane budding (GO:0006900)2.66828852
148negative regulation of transcription by competitive promoter binding (GO:0010944)2.65952483
149O-glycan processing (GO:0016266)2.65166579
150trivalent inorganic anion homeostasis (GO:0072506)2.64192818
151phosphate ion homeostasis (GO:0055062)2.64192818
152regulation of response to osmotic stress (GO:0047484)2.63600499
153hydrogen peroxide metabolic process (GO:0042743)2.61783011
154regulation of skeletal muscle contraction (GO:0014819)2.61519285
155regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.61491059
156response to vitamin A (GO:0033189)2.60084738
157sperm motility (GO:0030317)2.57495811
158respiratory gaseous exchange (GO:0007585)2.55918841
159negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.54971422
160axis elongation (GO:0003401)2.54421926
161retinal metabolic process (GO:0042574)2.54324627
162toxin metabolic process (GO:0009404)2.53690029
163negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.53499138
164cell-cell junction assembly (GO:0007043)2.53207027
165drug catabolic process (GO:0042737)2.52478607
166centriole replication (GO:0007099)2.50258015
167cilium or flagellum-dependent cell motility (GO:0001539)16.2259717
168cilium movement (GO:0003341)14.4550270
169motile cilium assembly (GO:0044458)13.9184008
170surfactant homeostasis (GO:0043129)13.1217196
171epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)12.9208470
172epithelial cilium movement (GO:0003351)12.6658264
173chemical homeostasis within a tissue (GO:0048875)10.2720720

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.12209622
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.25540839
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.19078621
4TRIM28_21343339_ChIP-Seq_HEK293_Human4.32006515
5RARG_19884340_ChIP-ChIP_MEFs_Mouse4.22889766
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.35214057
7ESR1_21235772_ChIP-Seq_MCF-7_Human3.28039447
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.23953878
9ESR1_20079471_ChIP-ChIP_T-47D_Human3.04499095
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.94049570
11CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.89787484
12DROSHA_22980978_ChIP-Seq_HELA_Human2.76248373
13SOX2_27498859_Chip-Seq_STOMACH_Mouse2.69457008
14CLOCK_20551151_ChIP-Seq_293T_Human2.67727967
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.57703927
16* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.40659662
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.35798547
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.31337896
19CDX2_20551321_ChIP-Seq_CACO-2_Human2.27694641
20* SOX2_20726797_ChIP-Seq_SW620_Human2.21773875
21KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.13690458
22HIF1A_21447827_ChIP-Seq_MCF-7_Human2.12002024
23ZNF263_19887448_ChIP-Seq_K562_Human2.09198772
24SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.06629981
25GATA4_25053715_ChIP-Seq_YYC3_Human2.05520430
26SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.05325647
27SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.05325647
28PPAR_26484153_Chip-Seq_NCI-H1993_Human2.02848889
29RACK7_27058665_Chip-Seq_MCF-7_Human1.95020127
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.91921258
31* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.89061771
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.85072281
33ESR1_15608294_ChIP-ChIP_MCF-7_Human1.84728587
34KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.83874395
35GATA1_22025678_ChIP-Seq_K562_Human1.73839846
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.73686669
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.70891005
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.69874610
39STAT1_20625510_ChIP-Seq_HELA_Human1.69325693
40RUNX1_27514584_Chip-Seq_MCF-7_Human1.69229616
41GATA6_25053715_ChIP-Seq_YYC3_Human1.63689686
42* SMC4_20622854_ChIP-Seq_HELA_Human1.62974288
43TP63_23658742_ChIP-Seq_EP156T_Human1.62729099
44SALL4_18804426_ChIP-ChIP_XEN_Mouse1.61111177
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.59292117
46TCF3_18692474_ChIP-Seq_MEFs_Mouse1.57709033
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.57689442
48FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.54943821
49ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.53333445
50PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.52506930
51TP63_22573176_ChIP-Seq_HFKS_Human1.52165019
52SOX9_24532713_ChIP-Seq_HFSC_Mouse1.52003578
53ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.50917064
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.50670973
55ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.50019266
56RAD21_21589869_ChIP-Seq_MESCs_Mouse1.47712951
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47111020
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.45658735
59GATA3_24758297_ChIP-Seq_MCF-7_Human1.44294294
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42113434
61PPARA_22158963_ChIP-Seq_LIVER_Mouse1.41370847
62* FOXA1_25552417_ChIP-Seq_VCAP_Human1.40970639
63AHR_22903824_ChIP-Seq_MCF-7_Human1.40359152
64RXR_22158963_ChIP-Seq_LIVER_Mouse1.39244364
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39122453
66ATF3_27146783_Chip-Seq_COLON_Human1.38373903
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.38214802
68SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.38111910
69KLF5_25053715_ChIP-Seq_YYC3_Human1.36640648
70LXR_22158963_ChIP-Seq_LIVER_Mouse1.36473299
71AR_21909140_ChIP-Seq_LNCAP_Human1.35561553
72P63_26484246_Chip-Seq_KERATINOCYTES_Human1.30587000
73SMAD3_21741376_ChIP-Seq_HESCs_Human1.28366474
74TDRD3_21172665_ChIP-Seq_MCF-7_Human1.28240794
75CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27689836
76ETV1_20927104_ChIP-Seq_GIST48_Human1.27592552
77* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27106516
78SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.25137867
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24992446
80ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.23362307
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23175997
82ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.22669151
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.22574931
84SOX2_18692474_ChIP-Seq_MEFs_Mouse1.22182543
85PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.21203665
86EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.20181181
87FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.19999930
88* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.18758502
89PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.18702713
90CREB1_26743006_Chip-Seq_LNCaP_Human1.18632517
91FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17193288
92NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.16928652
93CTCF_27219007_Chip-Seq_Bcells_Human1.16284180
94ELF1_20517297_ChIP-Seq_JURKAT_Human1.16164953
95CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.15930207
96NANOG_18692474_ChIP-Seq_MEFs_Mouse1.15327721
97PHF8_20622853_ChIP-Seq_HELA_Human1.15257525
98ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.14626644
99CJUN_26792858_Chip-Seq_BT549_Human1.14088301
100NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12563649
101ELK3_25401928_ChIP-Seq_HUVEC_Human1.12455957
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11664508
103RBPJ_21746931_ChIP-Seq_IB4_Human1.10645803
104* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10431743
105FOXA2_19822575_ChIP-Seq_HepG2_Human1.10024898
106HNFA_21074721_ChIP-Seq_CACO-2_Human1.10009875
107JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09878892
108* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08344469
109VDR_22108803_ChIP-Seq_LS180_Human1.07945002
110SMRT_27268052_Chip-Seq_Bcells_Human1.07536042
111P68_20966046_ChIP-Seq_HELA_Human1.05718812
112* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05284380
113CTCF_20526341_ChIP-Seq_ESCs_Human1.04935164
114CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04612156
115ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03056134
116GATA1_19941826_ChIP-Seq_K562_Human1.01755907
117RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99758491
118SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99594934
119YY1_22570637_ChIP-Seq_MALME-3M_Human0.99188935
120TCF4_18268006_ChIP-ChIP_LS174T_Human0.98516742
121GATA6_21074721_ChIP-Seq_CACO-2_Human0.98342632
122CBX2_22325352_ChIP-Seq_293T-Rex_Human0.98002882
123TP53_18474530_ChIP-ChIP_U2OS_Human0.97225790
124PHF8_20622854_ChIP-Seq_HELA_Human0.97141355
125TBX20_22328084_ChIP-Seq_HEART_Mouse0.96977146
126TBX20_22080862_ChIP-Seq_HEART_Mouse0.96977146
127* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96730125
128E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96263489
129UBF1/2_26484160_Chip-Seq_HMECs_Human0.95112032
130GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94797175
131SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94477974
132OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94472012
133THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94411293
134CEBPB_22108803_ChIP-Seq_LS180_Human0.94178281
135P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.91536887
136CHD1_26751641_Chip-Seq_LNCaP_Human0.90806129
137CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90713126
138ARNT_22903824_ChIP-Seq_MCF-7_Human0.89028101
139CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88312529
140SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87797082
141CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86924488
142CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86753506
143SALL1_21062744_ChIP-ChIP_HESCs_Human0.86601541
144UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86326055
145P300_27268052_Chip-Seq_Bcells_Human0.86102404
146SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85747277
147ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85742647
148NFYA_21822215_ChIP-Seq_K562_Human0.85690579
149SOX2_21211035_ChIP-Seq_LN229_Human0.85440503
150ELF5_23300383_ChIP-Seq_T47D_Human0.85167402
151KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.85161968
152KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85161968
153FLI1_21867929_ChIP-Seq_CD8_Mouse0.83357485
154TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.79914443
155TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79712161
156TOP2B_26459242_ChIP-Seq_MCF-7_Human0.79239624
157NFYB_21822215_ChIP-Seq_K562_Human0.78710373

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog5.78409670
2MP0002653_abnormal_ependyma_morphology5.34650133
3MP0001958_emphysema4.15813127
4MP0010234_abnormal_vibrissa_follicle3.86749840
5MP0008789_abnormal_olfactory_epithelium3.74820747
6MP0009780_abnormal_chondrocyte_physiolo3.66707724
7MP0005083_abnormal_biliary_tract3.56680113
8MP0008875_abnormal_xenobiotic_pharmacok3.52859418
9MP0002132_abnormal_respiratory_system3.39135088
10MP0000537_abnormal_urethra_morphology3.36474095
11MP0004133_heterotaxia3.25612613
12MP0001984_abnormal_olfaction3.20283751
13MP0002138_abnormal_hepatobiliary_system2.88636515
14MP0005394_taste/olfaction_phenotype2.66229774
15MP0005499_abnormal_olfactory_system2.66229774
16MP0008995_early_reproductive_senescence2.64512396
17MP0005623_abnormal_meninges_morphology2.61157863
18MP0010368_abnormal_lymphatic_system2.55238126
19MP0008004_abnormal_stomach_pH2.50689520
20MP0002277_abnormal_respiratory_mucosa2.34885208
21MP0003878_abnormal_ear_physiology2.25231708
22MP0005377_hearing/vestibular/ear_phenot2.25231708
23MP0002139_abnormal_hepatobiliary_system2.24873353
24MP0003566_abnormal_cell_adhesion2.07449319
25MP0005388_respiratory_system_phenotype1.95063568
26MP0002133_abnormal_respiratory_system1.95063568
27MP0001177_atelectasis1.90279328
28MP0004272_abnormal_basement_membrane1.90193356
29MP0000566_synostosis1.82702554
30MP0010030_abnormal_orbit_morphology1.82663333
31MP0004264_abnormal_extraembryonic_tissu1.80836040
32MP0002295_abnormal_pulmonary_circulatio1.76699418
33MP0002098_abnormal_vibrissa_morphology1.75832316
34MP0009379_abnormal_foot_pigmentation1.75618378
35MP0001879_abnormal_lymphatic_vessel1.74143008
36MP0010678_abnormal_skin_adnexa1.72055643
37MP0005408_hypopigmentation1.69168788
38MP0005248_abnormal_Harderian_gland1.68944350
39MP0005167_abnormal_blood-brain_barrier1.68041164
40MP0003191_abnormal_cellular_cholesterol1.67675571
41MP0006054_spinal_hemorrhage1.57458204
42MP0002160_abnormal_reproductive_system1.56423041
43MP0002796_impaired_skin_barrier1.53326755
44MP0010352_gastrointestinal_tract_polyps1.52988311
45MP0001849_ear_inflammation1.52974238
46MP0003300_gastrointestinal_ulcer1.50726569
47MP0003186_abnormal_redox_activity1.47024643
48MP0002254_reproductive_system_inflammat1.46209327
49MP0003656_abnormal_erythrocyte_physiolo1.45630212
50MP0004019_abnormal_vitamin_homeostasis1.45270124
51MP0002249_abnormal_larynx_morphology1.38091838
52MP0009643_abnormal_urine_homeostasis1.37101135
53MP0005165_increased_susceptibility_to1.35396675
54MP0000462_abnormal_digestive_system1.30652547
55MP0003115_abnormal_respiratory_system1.30491741
56MP0002234_abnormal_pharynx_morphology1.28845734
57MP0000534_abnormal_ureter_morphology1.28589331
58MP0003453_abnormal_keratinocyte_physiol1.28372139
59MP0001346_abnormal_lacrimal_gland1.26751087
60MP0005023_abnormal_wound_healing1.24664023
61MP0005275_abnormal_skin_tensile1.18530457
62MP0002136_abnormal_kidney_physiology1.17786916
63MP0005085_abnormal_gallbladder_physiolo1.15334354
64MP0001756_abnormal_urination1.14903858
65MP0000383_abnormal_hair_follicle1.13565612
66MP0000762_abnormal_tongue_morphology1.12581674
67MP0003806_abnormal_nucleotide_metabolis1.07771336
68MP0002876_abnormal_thyroid_physiology1.07767659
69MP0000465_gastrointestinal_hemorrhage1.07534702
70MP0002168_other_aberrant_phenotype1.06960913
71MP0004883_abnormal_blood_vessel1.06530225
72MP0001175_abnormal_lung_morphology1.04169512
73MP0005367_renal/urinary_system_phenotyp1.04011683
74MP0000516_abnormal_urinary_system1.04011683
75MP0003724_increased_susceptibility_to1.03999485
76MP0005164_abnormal_response_to1.03161722
77MP0001765_abnormal_ion_homeostasis1.02078779
78MP0003786_premature_aging0.96824189
79MP0000467_abnormal_esophagus_morphology0.96405811
80MP0003705_abnormal_hypodermis_morpholog0.95718855
81MP0005501_abnormal_skin_physiology0.94029874
82MP0001666_abnormal_nutrient_absorption0.93256839
83MP0001485_abnormal_pinna_reflex0.90201324
84MP0000613_abnormal_salivary_gland0.88630310
85MP0009053_abnormal_anal_canal0.88238406
86MP0004885_abnormal_endolymph0.88017010
87MP0005636_abnormal_mineral_homeostasis0.87722756
88MP0002877_abnormal_melanocyte_morpholog0.87266899
89MP0000627_abnormal_mammary_gland0.86492156
90MP0002060_abnormal_skin_morphology0.83453410
91MP0001664_abnormal_digestion0.83234151
92MP0003718_maternal_effect0.83032553
93MP0000678_abnormal_parathyroid_gland0.82052204
94MP0003941_abnormal_skin_development0.81479720
95MP0003119_abnormal_digestive_system0.81422523
96MP0003303_peritoneal_inflammation0.80160033
97MP0001216_abnormal_epidermal_layer0.79530312
98MP0000681_abnormal_thyroid_gland0.77671620
99MP0000343_altered_response_to0.77471914
100MP0002909_abnormal_adrenal_gland0.76071588
101MP0002282_abnormal_trachea_morphology0.75562372
102MP0005166_decreased_susceptibility_to0.75460245
103MP0005395_other_phenotype0.74884407
104MP0000858_altered_metastatic_potential0.74516357
105MP0000249_abnormal_blood_vessel0.73777091
106MP0003938_abnormal_ear_development0.73660457
107MP0002135_abnormal_kidney_morphology0.73354110
108MP0003942_abnormal_urinary_system0.72397063
109MP0001293_anophthalmia0.70454209
110MP0002734_abnormal_mechanical_nocicepti0.69427817
111MP0002233_abnormal_nose_morphology0.69280817
112MP0001929_abnormal_gametogenesis0.68864633
113MP0005389_reproductive_system_phenotype0.66912178
114MP0009764_decreased_sensitivity_to0.66694318
115MP0001502_abnormal_circadian_rhythm0.66340354
116MP0004043_abnormal_pH_regulation0.65487646
117MP0009765_abnormal_xenobiotic_induced0.65116099
118MP0003136_yellow_coat_color0.63875538
119MP0003890_abnormal_embryonic-extraembry0.62811526
120MP0003279_aneurysm0.62383463
121MP0003638_abnormal_response/metabolism_0.59690786
122MP0003937_abnormal_limbs/digits/tail_de0.59314398
123MP0002735_abnormal_chemical_nociception0.59129186
124MP0005365_abnormal_bile_salt0.58901613
125MP0010771_integument_phenotype0.58750252
126MP0005220_abnormal_exocrine_pancreas0.57310707
127MP0005058_abnormal_lysosome_morphology0.57303761
128MP0002925_abnormal_cardiovascular_devel0.57208328
129MP0010155_abnormal_intestine_physiology0.57198445
130MP0005332_abnormal_amino_acid0.56631237
131MP0000049_abnormal_middle_ear0.55441141
132MP0001324_abnormal_eye_pigmentation0.55413870
133MP0000470_abnormal_stomach_morphology0.55357431
134MP0005310_abnormal_salivary_gland0.54898509
135MP0000477_abnormal_intestine_morphology0.54374229
136MP0002084_abnormal_developmental_patter0.54195510
137MP0003866_abnormal_defecation0.53227187
138MP0003698_abnormal_male_reproductive0.52625620
139MP0001663_abnormal_digestive_system0.50798226
140MP0000026_abnormal_inner_ear0.50713046
141MP0002116_abnormal_craniofacial_bone0.50471722
142MP0009763_increased_sensitivity_to0.49670148
143MP0001270_distended_abdomen0.49532321
144MP0003075_altered_response_to0.48386406
145MP0009703_decreased_birth_body0.47666507
146MP0002896_abnormal_bone_mineralization0.44809924
147MP0003950_abnormal_plasma_membrane0.44542136

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)8.93907134
2Interstitial pulmonary disease (HP:0006530)8.44563602
3Chronic bronchitis (HP:0004469)7.37262929
4Renal salt wasting (HP:0000127)7.31206983
5Abnormality of chloride homeostasis (HP:0011422)5.83721450
6Onycholysis (HP:0001806)5.80779042
7Gout (HP:0001997)5.42198452
8Tubulointerstitial fibrosis (HP:0005576)5.22794239
9Hyperaldosteronism (HP:0000859)5.07845458
10Hypokalemic alkalosis (HP:0001949)4.45650357
11Hyperkalemia (HP:0002153)4.34706700
12Infertility (HP:0000789)4.30072670
13Recurrent sinusitis (HP:0011108)4.29899615
14Male infertility (HP:0003251)4.15719512
15Chronic sinusitis (HP:0011109)4.01340996
16Abnormality of renin-angiotensin system (HP:0000847)3.95226245
17Recurrent otitis media (HP:0000403)3.82056927
18Hyponatremia (HP:0002902)3.49902424
19Tubulointerstitial nephritis (HP:0001970)3.49127506
20Decreased circulating renin level (HP:0003351)3.44638027
21Rectal prolapse (HP:0002035)3.42460327
22Fragile nails (HP:0001808)3.41170978
23Occipital encephalocele (HP:0002085)3.39764177
24Milia (HP:0001056)3.36319438
25Polycythemia (HP:0001901)3.34573465
26Ulnar bowing (HP:0003031)3.33291741
27Esophageal varix (HP:0002040)3.29132502
28Hypotension (HP:0002615)3.28446601
29Tachypnea (HP:0002789)3.27747090
30Abnormality of cochlea (HP:0000375)3.24121460
31Tubular atrophy (HP:0000092)3.22294903
32Respiratory distress (HP:0002098)3.18563317
33Abnormality of the nasal mucosa (HP:0000433)3.13738573
34True hermaphroditism (HP:0010459)3.11380364
35Tubulointerstitial abnormality (HP:0001969)3.11169477
36Pancreatic fibrosis (HP:0100732)3.10671148
37Right ventricular cardiomyopathy (HP:0011663)3.05541282
38Bronchitis (HP:0012387)3.02360333
39Atelectasis (HP:0100750)3.01141232
40Glomerulosclerosis (HP:0000096)2.99779280
41Abnormality of sodium homeostasis (HP:0010931)2.98200001
42Vascular calcification (HP:0004934)2.97047577
43Chronic otitis media (HP:0000389)2.96089098
44Bronchomalacia (HP:0002780)2.95445671
45Atrophic scars (HP:0001075)2.89079053
46Increased purine levels (HP:0004368)2.87077531
47Hyperuricemia (HP:0002149)2.87077531
48Abnormality of renal excretion (HP:0011036)2.79626577
49Bronchiectasis (HP:0002110)2.76355354
50Stenosis of the external auditory canal (HP:0000402)2.74446091
51Cystic liver disease (HP:0006706)2.65598924
52Cardiovascular calcification (HP:0011915)2.64154501
53Adrenal overactivity (HP:0002717)2.62855178
54Synostosis involving the elbow (HP:0003938)2.61598868
55Humeroradial synostosis (HP:0003041)2.61598868
56Pustule (HP:0200039)2.57453067
57Pancreatic cysts (HP:0001737)2.53441964
58Molar tooth sign on MRI (HP:0002419)2.51064979
59Abnormality of midbrain morphology (HP:0002418)2.51064979
60Dehydration (HP:0001944)2.50343811
61Abnormal hemoglobin (HP:0011902)2.50251699
62Micronodular cirrhosis (HP:0001413)2.46015387
63Ileus (HP:0002595)2.41115630
64Bowed forearm bones (HP:0003956)2.38690665
65Bowing of the arm (HP:0006488)2.38690665
66Hematochezia (HP:0002573)2.35373172
67Alkalosis (HP:0001948)2.33733951
68Nephronophthisis (HP:0000090)2.32283833
69Abnormality of potassium homeostasis (HP:0011042)2.23445472
70Plantar hyperkeratosis (HP:0007556)2.21883246
71Postaxial foot polydactyly (HP:0001830)2.15521695
72Arterial tortuosity (HP:0005116)2.14051048
73Chronic hepatic failure (HP:0100626)2.13386431
74Nasal polyposis (HP:0100582)2.11363752
75Hypoplasia of dental enamel (HP:0006297)2.10098286
76Abnormality of purine metabolism (HP:0004352)2.06637583
77Tetany (HP:0001281)2.06316914
78Vascular tortuosity (HP:0004948)2.03943148
79Bell-shaped thorax (HP:0001591)2.02354633
80Visceral angiomatosis (HP:0100761)2.01794632
81Esophageal atresia (HP:0002032)2.00663784
82Abnormal respiratory motile cilium morphology (HP:0005938)11.0072335
83Abnormal respiratory epithelium morphology (HP:0012253)11.0072335
84Abnormal respiratory motile cilium physiology (HP:0012261)10.8673806
85Dynein arm defect of respiratory motile cilia (HP:0012255)10.5604609
86Absent/shortened dynein arms (HP:0200106)10.5604609
87Abnormal ciliary motility (HP:0012262)10.4976783
88Rhinitis (HP:0012384)10.2139995
89Stomach cancer (HP:0012126)1.99265859
90Hypokalemia (HP:0002900)1.96928107
91Abnormality of the distal phalanges of the toes (HP:0010182)1.96195577
92Metabolic alkalosis (HP:0200114)1.96098003
93Labial hypoplasia (HP:0000066)1.93077563
94Subacute progressive viral hepatitis (HP:0006572)1.90579747
95Curly hair (HP:0002212)1.90305228
96Abnormality of the renal medulla (HP:0100957)1.89867958
97Morphological abnormality of the inner ear (HP:0011390)1.88392908
98Focal segmental glomerulosclerosis (HP:0000097)1.87508492
99Anencephaly (HP:0002323)1.86658251
100Spontaneous hematomas (HP:0007420)1.84563377
101Pili torti (HP:0003777)1.83917275
102Aplasia/Hypoplasia of the tongue (HP:0010295)1.82800621
103Hemangiomatosis (HP:0007461)1.82368371
104Abnormal blistering of the skin (HP:0008066)1.81816771
105Male pseudohermaphroditism (HP:0000037)1.81690051
106Goiter (HP:0000853)1.81253982
107Hypoplastic female external genitalia (HP:0012815)1.80050137
108Woolly hair (HP:0002224)1.78430416
109Congenital hepatic fibrosis (HP:0002612)1.77743429
110Abnormality of the gastric mucosa (HP:0004295)1.76917024
111Split foot (HP:0001839)1.76425908
112Single umbilical artery (HP:0001195)1.73131707
113Abnormality of the fetal cardiovascular system (HP:0010948)1.73131707
114Abnormal umbilical cord blood vessels (HP:0011403)1.73131707
115Thyroid-stimulating hormone excess (HP:0002925)1.71768570
116Abnormality of the renal cortex (HP:0011035)1.70760376
117Medial flaring of the eyebrow (HP:0010747)1.69400976
118Aplasia/Hypoplasia of the spleen (HP:0010451)1.68943570
119Osteolytic defects of the hand bones (HP:0009699)1.67774321
120Osteolytic defects of the phalanges of the hand (HP:0009771)1.67774321
121Nail dystrophy (HP:0008404)1.66955595
122Stage 5 chronic kidney disease (HP:0003774)1.66244823
123Absent frontal sinuses (HP:0002688)1.65367359
124Popliteal pterygium (HP:0009756)1.64534096
125Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.64372196
126Recurrent bronchitis (HP:0002837)1.64233573
127Down-sloping shoulders (HP:0200021)1.62778297
128Vaginal fistula (HP:0004320)1.62592289
129Asplenia (HP:0001746)1.61933629
130Gastrointestinal atresia (HP:0002589)1.61543258
131Choanal stenosis (HP:0000452)1.60657347
132Breast carcinoma (HP:0003002)1.60508196
133Hypercalciuria (HP:0002150)1.60326264
134Congenital primary aphakia (HP:0007707)1.59830816
135Chondrocalcinosis (HP:0000934)1.59604870
136Nephropathy (HP:0000112)1.58460717
137Bifid scrotum (HP:0000048)1.56755315
138Alopecia of scalp (HP:0002293)1.55728836
139Gait imbalance (HP:0002141)1.54940247
140Lip pit (HP:0100267)1.52497339
141Oculomotor apraxia (HP:0000657)1.50675010
142Furrowed tongue (HP:0000221)1.49124413
143Sclerocornea (HP:0000647)1.46276922
144Median cleft lip (HP:0000161)1.46272514
145Abnormality of monocarboxylic acid metabolism (HP:0010996)1.43822114
146Taurodontia (HP:0000679)1.41373109
147Abnormality of permanent molar morphology (HP:0011071)1.41373109
148Abnormality of the dental root (HP:0006486)1.41373109
149Postaxial hand polydactyly (HP:0001162)1.40898590
150Nephrogenic diabetes insipidus (HP:0009806)1.37172101
151Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.32089262
152Abnormality of molar morphology (HP:0011070)1.29404128
153Abnormality of molar (HP:0011077)1.29404128
154Hand muscle atrophy (HP:0009130)1.27697018
155Flat acetabular roof (HP:0003180)1.27297216
156Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.26890110
157Glucose intolerance (HP:0000833)1.25822431
158Abnormality of the dental pulp (HP:0006479)1.25136402
159Cone-rod dystrophy (HP:0000548)1.25046777
160Preaxial hand polydactyly (HP:0001177)1.20062164
161Short thorax (HP:0010306)1.18877186
162Short nail (HP:0001799)1.18598357
163Carpal bone hypoplasia (HP:0001498)1.16815778
164Aplasia of the musculature (HP:0100854)1.13455685
165Spinal cord compression (HP:0002176)1.12278638
166Vaginal atresia (HP:0000148)1.10675531
167Obstructive sleep apnea (HP:0002870)1.10674237
168Genital tract atresia (HP:0001827)1.09954804
169Spinal muscular atrophy (HP:0007269)1.06638520
170Facial cleft (HP:0002006)1.05207002
171Short femoral neck (HP:0100864)1.03065044
172Limb-girdle muscle atrophy (HP:0003797)1.02795383
173Poor coordination (HP:0002370)1.02716733
174Abnormality of the frontal sinuses (HP:0002687)1.02019991
175Fetal akinesia sequence (HP:0001989)1.01781308

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.41954980
2LMTK24.83090032
3MST44.13238240
4TGFBR22.78009945
5EPHB22.75000814
6PAK42.66863823
7SMG12.57188758
8LRRK22.52932780
9MAP3K32.44929670
10DAPK22.37350936
11MST1R2.26582742
12FER2.23650358
13STK102.20989295
14MAP3K22.14834626
15EPHB12.10250691
16TTK2.04255919
17TIE11.99511616
18TESK11.88056749
19ERBB31.86822765
20RPS6KB21.85467898
21PTK21.83825394
22FGFR21.81036149
23WNK41.73725633
24ZAP701.59004747
25FRK1.54212951
26PTK61.53752585
27PRKG21.47152801
28MAP2K21.42018568
29STK241.41782142
30EEF2K1.38424554
31LATS11.36828960
32TRIB31.32700777
33NEK61.30467376
34MAPK151.26210809
35MET1.19730016
36MYLK1.18800278
37MAP2K31.15398977
38RIPK11.12664533
39MAP3K121.12656059
40ILK1.12553015
41TRPM71.12445885
42CDK61.12100849
43EPHA31.10597153
44FGFR41.10512486
45STK38L1.08415170
46STK391.04258834
47TGFBR11.02814597
48PBK1.01746055
49ERN10.98817962
50MAP3K70.97938558
51MAP3K110.97061009
52PDGFRB0.96784430
53PTK2B0.95000434
54MARK20.94226406
55NEK90.92525551
56STK380.88604874
57LIMK10.87066325
58GRK10.86899843
59MAP2K10.85181128
60TLK10.81859934
61TBK10.79864410
62ERBB20.77801851
63STK160.74972553
64PRKCI0.73391329
65PNCK0.73161830
66TAOK10.70988100
67BRSK20.70769905
68RPS6KA40.65465242
69TEC0.61633048
70ICK0.57740827
71MAP3K80.56597015
72GSK3A0.53536268
73EGFR0.51044986
74MAP3K10.50396768
75ARAF0.49609421
76MATK0.49200604
77STK30.49042386
78ERBB40.47699407
79PKN20.47483332
80CAMK2G0.47431832
81DDR20.45655895
82FGFR10.45222621
83FGFR30.44913352
84CDK190.43996098
85OXSR10.41550379
86DAPK30.41361760
87HIPK20.39976250
88MAP2K60.39820909
89PRKD10.38234228
90PDGFRA0.36185196
91CHUK0.35435519
92CSK0.35189188
93CAMKK10.35033443
94PDPK10.34688190
95KSR20.34373624
96KDR0.34325436
97PRKAA20.34269009
98CDK90.33519429
99CDC42BPA0.33363569
100TTN0.33142225
101PRKCQ0.32642860
102SIK10.32407239
103ITK0.32121488
104BMX0.31070775
105ROCK20.30436264
106BCR0.30184977
107DYRK1B0.29780101
108PLK10.29123484
109RIPK40.29104254
110SGK30.29093178
111IRAK10.28742709
112PDK20.28686517
113ROCK10.28479222
114SGK10.28285190
115AKT20.26542092
116GRK60.25459072
117SRC0.25363741
118PRKCE0.24195951
119ABL10.23991410
120MAPKAPK20.23422737
121NME10.23307513
122PRKCD0.23017539
123IGF1R0.22794736
124DAPK10.22139885
125PRKCA0.20525431
126MELK0.20353407
127DMPK0.20170304
128AURKB0.19340936
129TAOK20.18942876
130RPS6KA20.18916727
131MAPKAPK30.18289129
132PRKACA0.17575262
133NLK0.16779071
134PAK10.16497839
135MAP3K90.16429247
136TSSK60.16189939
137ABL20.15715519
138AURKA0.15457545
139MAPKAPK50.13821956
140ADRBK10.11063672
141CHEK20.09207122
142MAP3K40.08196434

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.44123153
2Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.43021726
3Chemical carcinogenesis_Homo sapiens_hsa052043.65993434
4Glutathione metabolism_Homo sapiens_hsa004803.46736266
5Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049603.01777322
6Mineral absorption_Homo sapiens_hsa049782.86745782
7Huntingtons disease_Homo sapiens_hsa050162.40001494
8ECM-receptor interaction_Homo sapiens_hsa045122.32863985
9Adherens junction_Homo sapiens_hsa045202.29857148
10Histidine metabolism_Homo sapiens_hsa003402.29729665
11Bladder cancer_Homo sapiens_hsa052192.28127117
12Tight junction_Homo sapiens_hsa045302.24885855
13Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.99712181
14Retinol metabolism_Homo sapiens_hsa008301.99055115
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.92376673
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.86270963
17Sulfur metabolism_Homo sapiens_hsa009201.79335153
18Hippo signaling pathway_Homo sapiens_hsa043901.77500067
19Phenylalanine metabolism_Homo sapiens_hsa003601.68896570
20Sphingolipid metabolism_Homo sapiens_hsa006001.58977837
21Tyrosine metabolism_Homo sapiens_hsa003501.56545321
22Caffeine metabolism_Homo sapiens_hsa002321.54356231
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.52588139
24Small cell lung cancer_Homo sapiens_hsa052221.51927775
25Fatty acid degradation_Homo sapiens_hsa000711.49202684
26Thyroid cancer_Homo sapiens_hsa052161.42956021
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.39172603
28beta-Alanine metabolism_Homo sapiens_hsa004101.37556452
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.36796014
30Focal adhesion_Homo sapiens_hsa045101.32774041
31Vibrio cholerae infection_Homo sapiens_hsa051101.30183997
32Linoleic acid metabolism_Homo sapiens_hsa005911.24285581
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.23308133
34Proteoglycans in cancer_Homo sapiens_hsa052051.19969926
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19394878
36Sulfur relay system_Homo sapiens_hsa041221.18325511
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16405269
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11625717
39Lysosome_Homo sapiens_hsa041421.06581742
40Circadian rhythm_Homo sapiens_hsa047101.06538983
41TGF-beta signaling pathway_Homo sapiens_hsa043501.03721088
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.02240150
43Basal cell carcinoma_Homo sapiens_hsa052170.96149484
44Selenocompound metabolism_Homo sapiens_hsa004500.95204026
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92890419
46Amoebiasis_Homo sapiens_hsa051460.92405698
47Bile secretion_Homo sapiens_hsa049760.89071434
48Starch and sucrose metabolism_Homo sapiens_hsa005000.84796400
49Tryptophan metabolism_Homo sapiens_hsa003800.83661380
50Toxoplasmosis_Homo sapiens_hsa051450.83230815
51Ribosome_Homo sapiens_hsa030100.81400059
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.79250275
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79069600
54Phagosome_Homo sapiens_hsa041450.78232497
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77834314
56Hepatitis C_Homo sapiens_hsa051600.77338942
57Pertussis_Homo sapiens_hsa051330.77280575
58Arachidonic acid metabolism_Homo sapiens_hsa005900.74227843
59Pathways in cancer_Homo sapiens_hsa052000.73910277
60Thyroid hormone synthesis_Homo sapiens_hsa049180.73337023
61Peroxisome_Homo sapiens_hsa041460.70043809
62Notch signaling pathway_Homo sapiens_hsa043300.69808101
63Endometrial cancer_Homo sapiens_hsa052130.68479764
64Renin-angiotensin system_Homo sapiens_hsa046140.68457253
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66910426
66Renal cell carcinoma_Homo sapiens_hsa052110.64948204
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64197400
68Shigellosis_Homo sapiens_hsa051310.64057677
69Chronic myeloid leukemia_Homo sapiens_hsa052200.61748463
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61336540
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.56933069
72Salmonella infection_Homo sapiens_hsa051320.56334165
73Collecting duct acid secretion_Homo sapiens_hsa049660.54611996
74Pancreatic cancer_Homo sapiens_hsa052120.54262475
75Gastric acid secretion_Homo sapiens_hsa049710.51381664
76Complement and coagulation cascades_Homo sapiens_hsa046100.51280728
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51226888
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51094262
79Rap1 signaling pathway_Homo sapiens_hsa040150.50933430
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.47856712
81Fatty acid biosynthesis_Homo sapiens_hsa000610.46707896
82Other glycan degradation_Homo sapiens_hsa005110.45364342
83Malaria_Homo sapiens_hsa051440.43620409
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.41347841
85Apoptosis_Homo sapiens_hsa042100.40807456
86Choline metabolism in cancer_Homo sapiens_hsa052310.40746037
87MicroRNAs in cancer_Homo sapiens_hsa052060.40004141
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39261447
89Endocytosis_Homo sapiens_hsa041440.39145316
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38432692
91Metabolic pathways_Homo sapiens_hsa011000.38387230
92Viral myocarditis_Homo sapiens_hsa054160.37256682
93Melanoma_Homo sapiens_hsa052180.36747039
94Pentose phosphate pathway_Homo sapiens_hsa000300.36129018
95Hedgehog signaling pathway_Homo sapiens_hsa043400.34584096
96ABC transporters_Homo sapiens_hsa020100.33916257
97Arginine and proline metabolism_Homo sapiens_hsa003300.33612219
98Salivary secretion_Homo sapiens_hsa049700.32957301
99TNF signaling pathway_Homo sapiens_hsa046680.32820573
100VEGF signaling pathway_Homo sapiens_hsa043700.32111611
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31608966
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31283879
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30432417
104Fatty acid metabolism_Homo sapiens_hsa012120.29522240
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27991186
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.27798992
107Rheumatoid arthritis_Homo sapiens_hsa053230.27236527
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27212079
109Platelet activation_Homo sapiens_hsa046110.26711368
110Acute myeloid leukemia_Homo sapiens_hsa052210.26441148
111Prostate cancer_Homo sapiens_hsa052150.26404220
112Propanoate metabolism_Homo sapiens_hsa006400.25896480
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25879484
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.25594551
115Vitamin digestion and absorption_Homo sapiens_hsa049770.24981329
116Protein digestion and absorption_Homo sapiens_hsa049740.24338630
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23980214
118Taste transduction_Homo sapiens_hsa047420.23882313
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23600958
120Pyruvate metabolism_Homo sapiens_hsa006200.20759429
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.20639561
122N-Glycan biosynthesis_Homo sapiens_hsa005100.20336517
123Axon guidance_Homo sapiens_hsa043600.20223731
124Olfactory transduction_Homo sapiens_hsa047400.18763401
125Folate biosynthesis_Homo sapiens_hsa007900.17255220
126PPAR signaling pathway_Homo sapiens_hsa033200.16571297
127Arginine biosynthesis_Homo sapiens_hsa002200.16270909
128Ovarian steroidogenesis_Homo sapiens_hsa049130.14948395
129Hematopoietic cell lineage_Homo sapiens_hsa046400.13925797
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.12675649
131Cocaine addiction_Homo sapiens_hsa050300.11723047
132Autoimmune thyroid disease_Homo sapiens_hsa053200.11683535
133Wnt signaling pathway_Homo sapiens_hsa043100.11463880
134Pancreatic secretion_Homo sapiens_hsa049720.09376312
135p53 signaling pathway_Homo sapiens_hsa041150.07874233
136Cardiac muscle contraction_Homo sapiens_hsa042600.07513023
137Insulin resistance_Homo sapiens_hsa049310.07437634
138cAMP signaling pathway_Homo sapiens_hsa040240.07389874
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.04925787
140Phototransduction_Homo sapiens_hsa047440.03802301
141Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.02422760
142Type I diabetes mellitus_Homo sapiens_hsa049400.02261130
143Fructose and mannose metabolism_Homo sapiens_hsa000510.01111106
144Melanogenesis_Homo sapiens_hsa049160.00102778

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