WDR92

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with two WD40 repeat domains thought to be involved in an apoptosis via activation of caspase-3. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.90763261
2maturation of SSU-rRNA (GO:0030490)4.57916466
3behavioral response to nicotine (GO:0035095)4.26029457
4nucleobase biosynthetic process (GO:0046112)4.11484469
5folic acid-containing compound biosynthetic process (GO:0009396)4.10523142
6DNA replication initiation (GO:0006270)4.07689697
7mitotic metaphase plate congression (GO:0007080)4.06815409
8ribosomal large subunit biogenesis (GO:0042273)4.04277953
9water-soluble vitamin biosynthetic process (GO:0042364)4.01002388
10viral transcription (GO:0019083)3.99273978
11translational termination (GO:0006415)3.98147771
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.92905419
13purine nucleobase biosynthetic process (GO:0009113)3.92253212
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.91065361
15mitochondrial respiratory chain complex I assembly (GO:0032981)3.91065361
16NADH dehydrogenase complex assembly (GO:0010257)3.91065361
17CENP-A containing nucleosome assembly (GO:0034080)3.90714679
18protein complex biogenesis (GO:0070271)3.86990865
19formation of translation preinitiation complex (GO:0001731)3.86520198
20DNA strand elongation involved in DNA replication (GO:0006271)3.85940776
21chromatin remodeling at centromere (GO:0031055)3.84794491
22DNA unwinding involved in DNA replication (GO:0006268)3.84417952
23ribosomal small subunit biogenesis (GO:0042274)3.83153983
24ribosome assembly (GO:0042255)3.80070919
25DNA deamination (GO:0045006)3.77354155
26translational elongation (GO:0006414)3.76187735
27ribonucleoprotein complex biogenesis (GO:0022613)3.76010396
28protein localization to kinetochore (GO:0034501)3.75578425
29mitotic nuclear envelope disassembly (GO:0007077)3.73836002
30DNA strand elongation (GO:0022616)3.72197601
31mitochondrial respiratory chain complex assembly (GO:0033108)3.72134506
32telomere maintenance via semi-conservative replication (GO:0032201)3.71426717
33ribosome biogenesis (GO:0042254)3.70433679
34platelet dense granule organization (GO:0060155)3.64161755
35epithelial cilium movement (GO:0003351)3.59637815
36metaphase plate congression (GO:0051310)3.59181896
37DNA replication-dependent nucleosome assembly (GO:0006335)3.57026466
38DNA replication-dependent nucleosome organization (GO:0034723)3.57026466
39ubiquinone biosynthetic process (GO:0006744)3.54990520
40respiratory chain complex IV assembly (GO:0008535)3.53722872
41translational initiation (GO:0006413)3.52215338
42rRNA modification (GO:0000154)3.52000358
43rRNA processing (GO:0006364)3.48196854
44SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.48001131
45IMP biosynthetic process (GO:0006188)3.47727636
46mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.47003091
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.46138557
48RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.46138557
49membrane disassembly (GO:0030397)3.44006024
50nuclear envelope disassembly (GO:0051081)3.44006024
51cotranslational protein targeting to membrane (GO:0006613)3.41882664
52DNA replication checkpoint (GO:0000076)3.40887589
53DNA replication-independent nucleosome assembly (GO:0006336)3.39772951
54DNA replication-independent nucleosome organization (GO:0034724)3.39772951
55pseudouridine synthesis (GO:0001522)3.39611018
56proteasome assembly (GO:0043248)3.39527433
57protein targeting to ER (GO:0045047)3.38234756
58attachment of spindle microtubules to kinetochore (GO:0008608)3.37917725
59cellular ketone body metabolic process (GO:0046950)3.36761998
60rRNA metabolic process (GO:0016072)3.36282357
61L-fucose catabolic process (GO:0042355)3.34002865
62fucose catabolic process (GO:0019317)3.34002865
63L-fucose metabolic process (GO:0042354)3.34002865
64nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.33122143
65ubiquinone metabolic process (GO:0006743)3.30521115
66histone exchange (GO:0043486)3.30043732
67energy coupled proton transport, down electrochemical gradient (GO:0015985)3.28802853
68ATP synthesis coupled proton transport (GO:0015986)3.28802853
69axonemal dynein complex assembly (GO:0070286)3.27085308
70telomere maintenance via recombination (GO:0000722)3.26661991
71IMP metabolic process (GO:0046040)3.26512667
72detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.25339255
73protein-cofactor linkage (GO:0018065)3.25213324
74preassembly of GPI anchor in ER membrane (GO:0016254)3.23924889
75establishment of integrated proviral latency (GO:0075713)3.23017406
76nuclear pore organization (GO:0006999)3.22509202
77folic acid metabolic process (GO:0046655)3.22281310
78protein localization to endoplasmic reticulum (GO:0070972)3.21533519
79anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.21163434
80cilium or flagellum-dependent cell motility (GO:0001539)3.21119597
81piRNA metabolic process (GO:0034587)3.19845799
82establishment of protein localization to endoplasmic reticulum (GO:0072599)3.19806509
83negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.18224368
84telomere maintenance via telomere lengthening (GO:0010833)3.17986605
85spliceosomal snRNP assembly (GO:0000387)3.17867747
86cilium movement (GO:0003341)3.17864604
87regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.17306966
88negative regulation of mitotic sister chromatid separation (GO:2000816)3.16316020
89negative regulation of mitotic sister chromatid segregation (GO:0033048)3.16316020
90negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.16316020
91negative regulation of sister chromatid segregation (GO:0033046)3.16316020
92negative regulation of chromosome segregation (GO:0051985)3.15626559
93spindle checkpoint (GO:0031577)3.15310630
94nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.15127498
95cellular protein complex disassembly (GO:0043624)3.13315105
96exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.13157933
97protein localization to chromosome, centromeric region (GO:0071459)3.13058348
98negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.12782492
99cytochrome complex assembly (GO:0017004)3.12091501
100viral life cycle (GO:0019058)3.10158972
101positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.10119737
102establishment of chromosome localization (GO:0051303)3.09783706
103mitotic spindle assembly checkpoint (GO:0007094)3.09350877
104spindle assembly checkpoint (GO:0071173)3.09130767
105regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.09112272
106mitotic recombination (GO:0006312)3.08766806
107L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.07870606
108ketone body metabolic process (GO:1902224)3.07486770
109mitotic spindle checkpoint (GO:0071174)3.06995868
110maturation of 5.8S rRNA (GO:0000460)3.03216422
111mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.02889940
112translation (GO:0006412)3.02381831
113regulation of spindle organization (GO:0090224)3.01267185
114cellular component biogenesis (GO:0044085)3.00225085
115DNA double-strand break processing (GO:0000729)2.99786333
116pteridine-containing compound biosynthetic process (GO:0042559)2.98797554
117replication fork processing (GO:0031297)2.98455309
118somatic hypermutation of immunoglobulin genes (GO:0016446)2.98455098
119somatic diversification of immune receptors via somatic mutation (GO:0002566)2.98455098
120RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.97954929
121rRNA methylation (GO:0031167)2.97939878
122mitotic sister chromatid segregation (GO:0000070)2.97786611
123kinetochore organization (GO:0051383)2.97626839
124protein deneddylation (GO:0000338)2.97295798
125response to pheromone (GO:0019236)2.96828143
126regulation of cilium movement (GO:0003352)2.95163039
127negative regulation of telomere maintenance (GO:0032205)2.94362683
128mitotic chromosome condensation (GO:0007076)2.92517035
129negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.92221146
130negative regulation of ligase activity (GO:0051352)2.92221146
131transcription-coupled nucleotide-excision repair (GO:0006283)2.91282987
132axoneme assembly (GO:0035082)2.90758096
133mannosylation (GO:0097502)2.90395132
134cullin deneddylation (GO:0010388)2.89950813
135establishment of protein localization to mitochondrial membrane (GO:0090151)2.89387585
136termination of RNA polymerase III transcription (GO:0006386)2.87817288
137transcription elongation from RNA polymerase III promoter (GO:0006385)2.87817288
138deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.86734620
139nucleotide-excision repair, DNA gap filling (GO:0006297)2.85989462
140protein polyglutamylation (GO:0018095)2.85499089
141protein K6-linked ubiquitination (GO:0085020)2.82846519
142protein complex disassembly (GO:0043241)2.82256400
143spliceosomal complex assembly (GO:0000245)2.81324946
144tRNA processing (GO:0008033)2.80909545
145mitochondrial RNA metabolic process (GO:0000959)2.80047274
146L-methionine salvage (GO:0071267)2.79455506
147L-methionine biosynthetic process (GO:0071265)2.79455506
148amino acid salvage (GO:0043102)2.79455506
149regulation of mitotic spindle checkpoint (GO:1903504)2.78244746
150regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.78244746
151kynurenine metabolic process (GO:0070189)2.75702116
152regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.72478469
153rRNA catabolic process (GO:0016075)2.72148021
154recombinational repair (GO:0000725)2.70559310
155quinone biosynthetic process (GO:1901663)2.68600898
156protein neddylation (GO:0045116)2.66852458
157double-strand break repair via homologous recombination (GO:0000724)2.66721876
158GPI anchor metabolic process (GO:0006505)2.65620241
159base-excision repair, AP site formation (GO:0006285)2.62517290
160indolalkylamine metabolic process (GO:0006586)2.61774441
161intracellular protein transmembrane import (GO:0044743)2.61376807
162negative regulation of DNA-dependent DNA replication (GO:2000104)2.60833772
163electron transport chain (GO:0022900)2.57991798
164regulation of nuclear cell cycle DNA replication (GO:0033262)2.57054116
165GTP biosynthetic process (GO:0006183)2.56586648
166cornea development in camera-type eye (GO:0061303)2.55533636
167indole-containing compound catabolic process (GO:0042436)2.54987673
168indolalkylamine catabolic process (GO:0046218)2.54987673
169tryptophan catabolic process (GO:0006569)2.54987673
170nonmotile primary cilium assembly (GO:0035058)2.54508297
171reciprocal meiotic recombination (GO:0007131)2.53349211
172reciprocal DNA recombination (GO:0035825)2.53349211
173cilium organization (GO:0044782)2.52947889
174neural tube formation (GO:0001841)2.51278282
175respiratory electron transport chain (GO:0022904)2.49760780
176somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.49750013
177isotype switching (GO:0045190)2.49750013
178somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.49750013
179retinal cone cell development (GO:0046549)2.46798487
180chaperone-mediated protein transport (GO:0072321)2.46484570
181tRNA metabolic process (GO:0006399)2.44531685
182somite development (GO:0061053)2.42532401
183cilium morphogenesis (GO:0060271)2.42290100

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.79944961
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.38606735
3ZNF274_21170338_ChIP-Seq_K562_Hela3.97106318
4VDR_22108803_ChIP-Seq_LS180_Human3.79705716
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.70435526
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.57034342
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.33453771
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.26307069
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.22620217
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.18206561
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.09896795
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.98624899
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.89056630
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.87772747
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.85448165
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84682769
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.74664850
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.59399639
19* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50670019
20GBX2_23144817_ChIP-Seq_PC3_Human2.48604643
21IGF1R_20145208_ChIP-Seq_DFB_Human2.48201885
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.46514285
23XRN2_22483619_ChIP-Seq_HELA_Human2.37376919
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.35832572
25VDR_23849224_ChIP-Seq_CD4+_Human2.34957199
26EWS_26573619_Chip-Seq_HEK293_Human2.34761043
27EZH2_22144423_ChIP-Seq_EOC_Human2.28590057
28FUS_26573619_Chip-Seq_HEK293_Human2.25322336
29AR_21909140_ChIP-Seq_LNCAP_Human2.24970393
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.23709143
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23042068
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.18071644
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16889694
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.15358209
35ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13974757
36ELF1_17652178_ChIP-ChIP_JURKAT_Human2.13827320
37FOXP3_21729870_ChIP-Seq_TREG_Human2.08670975
38POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08541639
39* DCP1A_22483619_ChIP-Seq_HELA_Human2.07971186
40* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06351689
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.05273050
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01788606
43GABP_19822575_ChIP-Seq_HepG2_Human1.96036602
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.94159920
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93743478
46ELK1_19687146_ChIP-ChIP_HELA_Human1.93357503
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.91881804
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.91613400
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86954752
50P300_19829295_ChIP-Seq_ESCs_Human1.86002673
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82762111
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82163515
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81165947
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80076154
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79094333
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.78265638
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.75796021
58TTF2_22483619_ChIP-Seq_HELA_Human1.73928901
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72355576
60* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71729200
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.70780344
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.70302303
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69875001
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61377727
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60631397
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59629384
67TP53_22573176_ChIP-Seq_HFKS_Human1.59134178
68TAF15_26573619_Chip-Seq_HEK293_Human1.58889892
69ER_23166858_ChIP-Seq_MCF-7_Human1.58567692
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57854516
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.56198879
72* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55981223
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51819389
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.44667208
75EGR1_19374776_ChIP-ChIP_THP-1_Human1.43899445
76IRF1_19129219_ChIP-ChIP_H3396_Human1.43754984
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43581099
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41437737
79KDM5A_27292631_Chip-Seq_BREAST_Human1.41156624
80POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41088479
81NANOG_19829295_ChIP-Seq_ESCs_Human1.40033350
82SOX2_19829295_ChIP-Seq_ESCs_Human1.40033350
83FOXA1_27270436_Chip-Seq_PROSTATE_Human1.38453329
84FOXA1_25329375_ChIP-Seq_VCAP_Human1.38453329
85* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38016621
86CIITA_25753668_ChIP-Seq_RAJI_Human1.36434987
87* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35299569
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35168994
89* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34847284
90CBP_20019798_ChIP-Seq_JUKART_Human1.33688424
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33688424
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30720724
93SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29664229
94BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26774294
95CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26004126
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25458167
97SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24023873
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23397063
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21084385
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20776207
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20513500
102CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20255271
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19318981
104FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18980662
105NFE2_27457419_Chip-Seq_LIVER_Mouse1.18592855
106BCAT_22108803_ChIP-Seq_LS180_Human1.18269450
107EZH2_27294783_Chip-Seq_NPCs_Mouse1.18170609
108NOTCH1_21737748_ChIP-Seq_TLL_Human1.17226869
109MYC_22102868_ChIP-Seq_BL_Human1.15101314
110RNF2_27304074_Chip-Seq_NSC_Mouse1.15014797
111FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14676188
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14410518
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14383796
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13775789
115E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11839751
116BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10727063
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10723054
118KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10575040
119TCF4_22108803_ChIP-Seq_LS180_Human1.10155977
120MYC_18940864_ChIP-ChIP_HL60_Human1.09989749
121GATA3_21878914_ChIP-Seq_MCF-7_Human1.09257057
122* AR_20517297_ChIP-Seq_VCAP_Human1.08897378
123ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08350017
124AR_25329375_ChIP-Seq_VCAP_Human1.07059398
125KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06968395
126ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06834658
127CBX2_27304074_Chip-Seq_ESCs_Mouse1.06716311
128CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06616110
129SMAD3_21741376_ChIP-Seq_EPCs_Human1.06399425
130EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06396375
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06329070
132STAT3_23295773_ChIP-Seq_U87_Human1.06327205
133TFEB_21752829_ChIP-Seq_HELA_Human1.05253478
134* NCOR_22424771_ChIP-Seq_293T_Human1.03446945
135NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01677692
136SMAD4_21799915_ChIP-Seq_A2780_Human1.01132284
137KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00615129
138HOXB7_26014856_ChIP-Seq_BT474_Human1.00153482
139CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00146544
140CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99983185
141RUNX2_22187159_ChIP-Seq_PCA_Human0.99654542
142TCF4_23295773_ChIP-Seq_U87_Human0.99483319
143KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98851405
144KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98851405
145KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98851405
146CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97312445
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97309778
148HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97165301
149ELK1_22589737_ChIP-Seq_MCF10A_Human0.95941394
150CRX_20693478_ChIP-Seq_RETINA_Mouse0.95687955
151DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94245788
152CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93784864
153RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93518193
154SOX2_16153702_ChIP-ChIP_HESCs_Human0.93154531
155PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92588223
156* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91871319
157TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91605852
158SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91301342
159AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89394200
160EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88658276
161P53_22387025_ChIP-Seq_ESCs_Mouse0.88108904
162SMAD4_21741376_ChIP-Seq_EPCs_Human0.88049022
163SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.87614879
164NANOG_21062744_ChIP-ChIP_HESCs_Human0.87125509
165CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86104776
166TCF3_18692474_ChIP-Seq_MEFs_Mouse0.84902697
167HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83500473
168HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83461397
169NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83442137
170SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81404398
171CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.81352657
172SOX2_18692474_ChIP-Seq_MEFs_Mouse0.80523377
173SPI1_23547873_ChIP-Seq_NB4_Human0.80295241

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.63448311
2MP0010094_abnormal_chromosome_stability4.48175934
3MP0004957_abnormal_blastocyst_morpholog4.42568948
4MP0003111_abnormal_nucleus_morphology4.08489834
5MP0003077_abnormal_cell_cycle3.81303191
6MP0008057_abnormal_DNA_replication3.73481782
7MP0003806_abnormal_nucleotide_metabolis3.51909772
8MP0008058_abnormal_DNA_repair3.26398811
9MP0002102_abnormal_ear_morphology3.12386967
10MP0008007_abnormal_cellular_replicative2.98605216
11MP0002396_abnormal_hematopoietic_system2.69121422
12MP0008877_abnormal_DNA_methylation2.64854781
13MP0003123_paternal_imprinting2.63935851
14MP0008932_abnormal_embryonic_tissue2.46631680
15MP0006072_abnormal_retinal_apoptosis2.40560740
16MP0005551_abnormal_eye_electrophysiolog2.35980579
17MP0003718_maternal_effect2.18283047
18MP0001730_embryonic_growth_arrest2.15941086
19MP0002638_abnormal_pupillary_reflex2.14484017
20MP0002234_abnormal_pharynx_morphology2.11783718
21MP0003195_calcinosis2.11343745
22MP0004885_abnormal_endolymph2.10645773
23MP0000350_abnormal_cell_proliferation2.07043716
24MP0003136_yellow_coat_color2.05459890
25MP0008995_early_reproductive_senescence1.99506510
26MP0003186_abnormal_redox_activity1.99316597
27MP0003786_premature_aging1.93636683
28MP0000372_irregular_coat_pigmentation1.90941529
29MP0005253_abnormal_eye_physiology1.88064408
30MP0003646_muscle_fatigue1.84850674
31MP0008872_abnormal_physiological_respon1.84619386
32MP0002653_abnormal_ependyma_morphology1.84327757
33MP0002837_dystrophic_cardiac_calcinosis1.77335205
34MP0001986_abnormal_taste_sensitivity1.74431724
35MP0005645_abnormal_hypothalamus_physiol1.73511701
36MP0001968_abnormal_touch/_nociception1.65989786
37MP0002876_abnormal_thyroid_physiology1.64375460
38MP0001529_abnormal_vocalization1.61139168
39MP0005646_abnormal_pituitary_gland1.60940574
40MP0004142_abnormal_muscle_tone1.60696591
41MP0001697_abnormal_embryo_size1.57028207
42MP0003011_delayed_dark_adaptation1.56870977
43MP0008789_abnormal_olfactory_epithelium1.56858531
44MP0010307_abnormal_tumor_latency1.56354776
45MP0005380_embryogenesis_phenotype1.54941094
46MP0001672_abnormal_embryogenesis/_devel1.54941094
47MP0001545_abnormal_hematopoietic_system1.53271487
48MP0005397_hematopoietic_system_phenotyp1.53271487
49MP0003787_abnormal_imprinting1.52818271
50MP0006036_abnormal_mitochondrial_physio1.51912991
51MP0002132_abnormal_respiratory_system1.50900364
52MP0009379_abnormal_foot_pigmentation1.50795613
53MP0004147_increased_porphyrin_level1.49799246
54MP0004808_abnormal_hematopoietic_stem1.48997634
55MP0005084_abnormal_gallbladder_morpholo1.47305070
56MP0002080_prenatal_lethality1.46952364
57MP0000569_abnormal_digit_pigmentation1.46891639
58MP0002736_abnormal_nociception_after1.46610336
59MP0001485_abnormal_pinna_reflex1.45259561
60MP0004145_abnormal_muscle_electrophysio1.43302166
61MP0003984_embryonic_growth_retardation1.42538940
62MP0000631_abnormal_neuroendocrine_gland1.42172984
63MP0003880_abnormal_central_pattern1.42050270
64MP0009046_muscle_twitch1.41699800
65MP0003119_abnormal_digestive_system1.40859217
66MP0009745_abnormal_behavioral_response1.40268061
67MP0002088_abnormal_embryonic_growth/wei1.38690547
68MP0006276_abnormal_autonomic_nervous1.37536249
69MP0000313_abnormal_cell_death1.37193510
70MP0002210_abnormal_sex_determination1.33852717
71MP0003315_abnormal_perineum_morphology1.33696242
72MP0000490_abnormal_crypts_of1.32582387
73MP0000427_abnormal_hair_cycle1.31536568
74MP0001984_abnormal_olfaction1.31525266
75MP0006292_abnormal_olfactory_placode1.30823618
76MP0002019_abnormal_tumor_incidence1.29432264
77MP0002085_abnormal_embryonic_tissue1.26061249
78MP0001929_abnormal_gametogenesis1.25867663
79MP0002272_abnormal_nervous_system1.24553207
80MP0009333_abnormal_splenocyte_physiolog1.24034415
81MP0001145_abnormal_male_reproductive1.23421351
82MP0004043_abnormal_pH_regulation1.23402683
83MP0010030_abnormal_orbit_morphology1.23254003
84MP0003763_abnormal_thymus_physiology1.23053803
85MP0001905_abnormal_dopamine_level1.23039947
86MP0010352_gastrointestinal_tract_polyps1.22284717
87MP0002084_abnormal_developmental_patter1.21216533
88MP0006035_abnormal_mitochondrial_morpho1.20019588
89MP0003567_abnormal_fetal_cardiomyocyte1.19225562
90MP0003283_abnormal_digestive_organ1.18895478
91MP0002086_abnormal_extraembryonic_tissu1.17927999
92MP0000049_abnormal_middle_ear1.17445130
93MP0003121_genomic_imprinting1.14817996
94MP0001501_abnormal_sleep_pattern1.13943009
95MP0006054_spinal_hemorrhage1.13872425
96MP0001764_abnormal_homeostasis1.12714646
97MP0000653_abnormal_sex_gland1.11956755
98MP0004133_heterotaxia1.09935650
99MP0002735_abnormal_chemical_nociception1.06729844
100MP0001486_abnormal_startle_reflex1.05422823
101MP0003656_abnormal_erythrocyte_physiolo1.05137983
102MP0000358_abnormal_cell_content/1.03909446
103MP0005195_abnormal_posterior_eye1.03504582
104MP0002277_abnormal_respiratory_mucosa1.02622059
105MP0000703_abnormal_thymus_morphology1.02204879
106MP0004197_abnormal_fetal_growth/weight/1.01428759
107MP0004215_abnormal_myocardial_fiber1.00463621
108MP0005174_abnormal_tail_pigmentation0.98802593
109MP0002095_abnormal_skin_pigmentation0.97962513
110MP0002722_abnormal_immune_system0.97659022
111MP0009053_abnormal_anal_canal0.97567261
112MP0005408_hypopigmentation0.97277387
113MP0000689_abnormal_spleen_morphology0.97237546
114MP0002751_abnormal_autonomic_nervous0.96512948
115MP0001293_anophthalmia0.95679882
116MP0005499_abnormal_olfactory_system0.94892108
117MP0005394_taste/olfaction_phenotype0.94892108
118MP0003221_abnormal_cardiomyocyte_apopto0.94685398
119MP0001119_abnormal_female_reproductive0.94640752
120MP0005266_abnormal_metabolism0.94108850
121MP0001188_hyperpigmentation0.93832317
122MP0009697_abnormal_copulation0.92568504
123MP0000678_abnormal_parathyroid_gland0.90897086
124MP0002398_abnormal_bone_marrow0.90529728
125MP0002557_abnormal_social/conspecific_i0.89926978
126MP0000647_abnormal_sebaceous_gland0.89428201
127MP0000516_abnormal_urinary_system0.88682668
128MP0005367_renal/urinary_system_phenotyp0.88682668
129MP0002572_abnormal_emotion/affect_behav0.86777923
130MP0000026_abnormal_inner_ear0.86370984
131MP0003890_abnormal_embryonic-extraembry0.86168381
132MP0005391_vision/eye_phenotype0.84877286
133MP0004742_abnormal_vestibular_system0.84334096
134MP0000383_abnormal_hair_follicle0.82718020
135MP0005410_abnormal_fertilization0.82260389
136MP0002160_abnormal_reproductive_system0.82208845
137MP0005389_reproductive_system_phenotype0.81613724
138MP0002752_abnormal_somatic_nervous0.79750170
139MP0003878_abnormal_ear_physiology0.79677062
140MP0005377_hearing/vestibular/ear_phenot0.79677062
141MP0005379_endocrine/exocrine_gland_phen0.79231744
142MP0001324_abnormal_eye_pigmentation0.78877288
143MP0003941_abnormal_skin_development0.78314958
144MP0005075_abnormal_melanosome_morpholog0.78125089
145MP0004924_abnormal_behavior0.76593798
146MP0005386_behavior/neurological_phenoty0.76593798
147MP0010386_abnormal_urinary_bladder0.76198171
148MP0005384_cellular_phenotype0.76171837
149MP0002938_white_spotting0.75335195
150MP0005023_abnormal_wound_healing0.74532878
151MP0002429_abnormal_blood_cell0.72749959
152MP0001849_ear_inflammation0.70400147
153MP0000537_abnormal_urethra_morphology0.66153491
154MP0005395_other_phenotype0.65975829
155MP0005621_abnormal_cell_physiology0.65901972
156MP0008875_abnormal_xenobiotic_pharmacok0.65714701
157MP0003699_abnormal_female_reproductive0.63276814
158MP0004264_abnormal_extraembryonic_tissu0.61308001
159MP0002127_abnormal_cardiovascular_syste0.60908704
160MP0003698_abnormal_male_reproductive0.60613704
161MP0001915_intracranial_hemorrhage0.60194897
162MP0000598_abnormal_liver_morphology0.59577184
163MP0005451_abnormal_body_composition0.57104235
164MP0002161_abnormal_fertility/fecundity0.56688201
165MP0000477_abnormal_intestine_morphology0.56016609
166MP0003937_abnormal_limbs/digits/tail_de0.55892552
167MP0009672_abnormal_birth_weight0.55312188
168MP0004084_abnormal_cardiac_muscle0.55030521
169MP0000716_abnormal_immune_system0.52834693
170MP0008873_increased_physiological_sensi0.51843234
171MP0005220_abnormal_exocrine_pancreas0.51557045
172MP0001919_abnormal_reproductive_system0.50698505

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.87989942
2Abnormal number of erythroid precursors (HP:0012131)4.65498141
3Aplastic anemia (HP:0001915)4.32039736
4Birth length less than 3rd percentile (HP:0003561)4.25166660
5True hermaphroditism (HP:0010459)4.24632521
6Pancreatic cysts (HP:0001737)4.19343659
7Reticulocytopenia (HP:0001896)4.08945966
8Breast hypoplasia (HP:0003187)4.05268026
9Abnormality of midbrain morphology (HP:0002418)4.02778239
10Molar tooth sign on MRI (HP:0002419)4.02778239
11Oral leukoplakia (HP:0002745)3.89168167
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.55941974
13Absent/shortened dynein arms (HP:0200106)3.55941974
14Nephronophthisis (HP:0000090)3.51322719
15Carpal bone hypoplasia (HP:0001498)3.21970321
16Chromsome breakage (HP:0040012)3.21288545
17Selective tooth agenesis (HP:0001592)3.19750671
18Congenital stationary night blindness (HP:0007642)3.18209692
19Macrocytic anemia (HP:0001972)3.13329527
20Abnormal respiratory motile cilium morphology (HP:0005938)3.08401488
21Abnormal respiratory epithelium morphology (HP:0012253)3.08401488
22Chronic hepatic failure (HP:0100626)3.04207804
23Abnormality of the anterior horn cell (HP:0006802)2.96325217
24Degeneration of anterior horn cells (HP:0002398)2.96325217
25Methylmalonic acidemia (HP:0002912)2.94436737
26Abnormality of the renal cortex (HP:0011035)2.91912323
27Rough bone trabeculation (HP:0100670)2.91459254
28Colon cancer (HP:0003003)2.88788534
29Supernumerary spleens (HP:0009799)2.88688847
30Abnormality of the renal medulla (HP:0100957)2.83152009
31Medulloblastoma (HP:0002885)2.82437489
32Medial flaring of the eyebrow (HP:0010747)2.81744327
33Renal cortical cysts (HP:0000803)2.75772631
34Abnormal ciliary motility (HP:0012262)2.74258026
3511 pairs of ribs (HP:0000878)2.71210692
36Abnormality of chromosome stability (HP:0003220)2.70998753
37Ependymoma (HP:0002888)2.69356375
38Cerebral hypomyelination (HP:0006808)2.67904713
39Sclerocornea (HP:0000647)2.66613541
40Chromosomal breakage induced by crosslinking agents (HP:0003221)2.66267285
41Stenosis of the external auditory canal (HP:0000402)2.64783722
42Pendular nystagmus (HP:0012043)2.63897313
43Abnormal respiratory motile cilium physiology (HP:0012261)2.63573967
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.63543516
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.63543516
46Abnormal spermatogenesis (HP:0008669)2.62398880
47Pallor (HP:0000980)2.62285246
48Progressive macrocephaly (HP:0004481)2.61182230
49Premature graying of hair (HP:0002216)2.60768154
50Microretrognathia (HP:0000308)2.60708244
51Absent thumb (HP:0009777)2.58200306
52Multiple enchondromatosis (HP:0005701)2.57879040
53Patellar aplasia (HP:0006443)2.53706655
54Hyperglycinemia (HP:0002154)2.53695130
55Increased CSF lactate (HP:0002490)2.51178281
56Increased serum lactate (HP:0002151)2.50490284
57Aplasia/Hypoplasia of the patella (HP:0006498)2.47365974
58Abnormality of the preputium (HP:0100587)2.46682907
59Hepatocellular necrosis (HP:0001404)2.43895918
60Pancytopenia (HP:0001876)2.43402350
61Myelodysplasia (HP:0002863)2.42739084
62Male pseudohermaphroditism (HP:0000037)2.41543021
63Increased hepatocellular lipid droplets (HP:0006565)2.40411466
64Type II lissencephaly (HP:0007260)2.39560957
65Cellular immunodeficiency (HP:0005374)2.38531933
66Hepatic necrosis (HP:0002605)2.37891861
67Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.37516549
68Methylmalonic aciduria (HP:0012120)2.37079864
69Abolished electroretinogram (ERG) (HP:0000550)2.36608583
70Mitochondrial inheritance (HP:0001427)2.34976036
71Abnormality of glycolysis (HP:0004366)2.34854932
72Increased serum pyruvate (HP:0003542)2.34854932
73Bone marrow hypocellularity (HP:0005528)2.34502797
74Attenuation of retinal blood vessels (HP:0007843)2.34029129
75Impulsivity (HP:0100710)2.32880127
76Cystic liver disease (HP:0006706)2.32298311
77Aplasia/Hypoplasia of the tongue (HP:0010295)2.31822612
78Lipid accumulation in hepatocytes (HP:0006561)2.31411193
79Meckel diverticulum (HP:0002245)2.29758504
80Absent radius (HP:0003974)2.28479036
81Renal Fanconi syndrome (HP:0001994)2.24298703
82Microvesicular hepatic steatosis (HP:0001414)2.23970020
83Cerebral edema (HP:0002181)2.23471758
84Abnormality of pyrimidine metabolism (HP:0004353)2.22175717
85Optic disc pallor (HP:0000543)2.21160455
86Absent rod-and cone-mediated responses on ERG (HP:0007688)2.21040545
87Abnormal biliary tract physiology (HP:0012439)2.20506398
88Bile duct proliferation (HP:0001408)2.20506398
89Abnormality of the ileum (HP:0001549)2.20053881
90Anencephaly (HP:0002323)2.18585955
91Megaloblastic anemia (HP:0001889)2.18526379
92Abnormal trabecular bone morphology (HP:0100671)2.18377348
93Aplasia/Hypoplasia of the sacrum (HP:0008517)2.17290489
94Congenital primary aphakia (HP:0007707)2.16598649
95Abnormal rod and cone electroretinograms (HP:0008323)2.16045941
96Agnosia (HP:0010524)2.15741791
97Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.15406323
98Gait imbalance (HP:0002141)2.15009727
99Abnormality of the heme biosynthetic pathway (HP:0010472)2.14902795
100Trismus (HP:0000211)2.14600667
101Optic nerve coloboma (HP:0000588)2.13352158
102CNS hypomyelination (HP:0003429)2.12960398
103Rhabdomyosarcoma (HP:0002859)2.12088976
104Neoplasm of the pancreas (HP:0002894)2.11773494
105Acute necrotizing encephalopathy (HP:0006965)2.11068369
106Secondary amenorrhea (HP:0000869)2.10594853
107Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.09381001
108Polydipsia (HP:0001959)2.09345853
109Abnormal drinking behavior (HP:0030082)2.09345853
110Rhinitis (HP:0012384)2.08973684
111Type I transferrin isoform profile (HP:0003642)2.08687239
112Furrowed tongue (HP:0000221)2.07696110
113Chorioretinal atrophy (HP:0000533)2.07164495
114Occipital encephalocele (HP:0002085)2.06481828
115Aplasia involving forearm bones (HP:0009822)2.05283957
116Absent forearm bone (HP:0003953)2.05283957
117Horseshoe kidney (HP:0000085)2.04462183
118Abnormal mitochondria in muscle tissue (HP:0008316)2.04266296
119Congenital hepatic fibrosis (HP:0002612)2.04218184
120Abnormal number of incisors (HP:0011064)2.03767827
121Thrombocytosis (HP:0001894)2.03293954
122Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.02160809
123Nephrogenic diabetes insipidus (HP:0009806)2.01412138
124Sloping forehead (HP:0000340)2.00377073
125Abnormality of the labia minora (HP:0012880)1.99715244
126Aplasia/hypoplasia of the uterus (HP:0008684)1.98966842
127Postaxial foot polydactyly (HP:0001830)1.98429693
128Premature ovarian failure (HP:0008209)1.97979149
129Lactic acidosis (HP:0003128)1.97337701
130Small intestinal stenosis (HP:0012848)1.96891998
131Duodenal stenosis (HP:0100867)1.96891998
132Tubular atrophy (HP:0000092)1.95840490
133Abnormality of glycine metabolism (HP:0010895)1.95446921
134Abnormality of serine family amino acid metabolism (HP:0010894)1.95446921
135Abnormality of alanine metabolism (HP:0010916)1.95250259
136Hyperalaninemia (HP:0003348)1.95250259
137Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95250259
138Hyperglycinuria (HP:0003108)1.94420773
139Respiratory difficulties (HP:0002880)1.94026171
140Congenital, generalized hypertrichosis (HP:0004540)1.93436006
141Exercise intolerance (HP:0003546)1.93288178
142Missing ribs (HP:0000921)1.93272488
1433-Methylglutaconic aciduria (HP:0003535)1.93160614
144Hypoplasia of the uterus (HP:0000013)1.93093734
145Decreased electroretinogram (ERG) amplitude (HP:0000654)1.92727450
146Aplasia/Hypoplasia of the tibia (HP:0005772)1.92388438
147Triphalangeal thumb (HP:0001199)1.91608350
148Acute encephalopathy (HP:0006846)1.90301096
149Aplasia/Hypoplasia of the uvula (HP:0010293)1.89218315
150Facial cleft (HP:0002006)1.88887119
151Abnormal lung lobation (HP:0002101)1.88835495
152Increased corneal curvature (HP:0100692)1.88194779
153Keratoconus (HP:0000563)1.88194779
154Abnormality of serum amino acid levels (HP:0003112)1.87663119
155Hyperventilation (HP:0002883)1.87568285
156Progressive inability to walk (HP:0002505)1.87492246
157Inability to walk (HP:0002540)1.87443686
158Bilateral microphthalmos (HP:0007633)1.87387504
159Pancreatic fibrosis (HP:0100732)1.86723876
160Squamous cell carcinoma (HP:0002860)1.86220868
161Abnormality of reticulocytes (HP:0004312)1.85018333
162Genital tract atresia (HP:0001827)1.82482445
163Lethargy (HP:0001254)1.82027904
164Concave nail (HP:0001598)1.81438102
165CNS demyelination (HP:0007305)1.80346467
166Muscle fiber atrophy (HP:0100295)1.77774716
167Vaginal atresia (HP:0000148)1.77596925
168Ketosis (HP:0001946)1.77436886
169Increased intramyocellular lipid droplets (HP:0012240)1.77268379
170Generalized aminoaciduria (HP:0002909)1.77036580
171Abnormality of vitamin B metabolism (HP:0004340)1.75872379
172Polyuria (HP:0000103)1.75514093
173Retinal dysplasia (HP:0007973)1.73872904
174Hypoplasia of the pons (HP:0012110)1.72140169

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.86059109
2WEE14.38968169
3STK163.35045568
4EIF2AK13.24812770
5FRK3.09691595
6CDC73.08358743
7PLK43.05442993
8NUAK12.73308468
9BMPR1B2.72955224
10ADRBK22.68358624
11SRPK12.66838008
12TSSK62.61131528
13NME22.57473010
14WNK32.40521159
15MAP4K22.35738784
16NEK22.26806428
17TTK2.25494845
18RPS6KB22.21691781
19PASK2.13051905
20BRSK22.11171112
21VRK22.10673207
22GRK12.08894098
23VRK12.05897770
24TRIM282.00863211
25EIF2AK31.96440191
26INSRR1.95100359
27PLK11.91594481
28ACVR1B1.81808663
29NEK11.77706110
30PINK11.67236550
31TAOK31.63488826
32WNK41.61589254
33AURKB1.59201735
34TESK21.58033873
35TGFBR11.51344204
36MAP3K41.48257005
37PLK31.46473156
38EEF2K1.45406831
39MAPK131.44915348
40ATR1.44174279
41BCKDK1.40371791
42STK101.39068387
43CDK71.37375853
44FLT31.36227550
45DYRK31.33635596
46PDK31.32993563
47PDK41.32993563
48MAPKAPK31.32316918
49MAP3K81.31061416
50MKNK11.27037444
51TLK11.24685815
52AURKA1.22716326
53OXSR11.19448059
54MAP2K71.16913789
55EPHA21.15801055
56ZAK1.12628535
57BRSK11.09820882
58TNIK1.09690619
59MAP3K31.05300153
60CASK1.04239073
61CHEK11.04107267
62CDK41.03209173
63CSNK1G11.03028108
64STK38L1.02666631
65CHEK20.99667059
66CSNK1G20.96884254
67MAPK150.94337475
68STK390.92271970
69PAK40.91404057
70RPS6KA40.90544963
71TESK10.88033194
72CSNK1G30.86148993
73PDK20.85374351
74STK40.85161950
75BCR0.85141389
76TAF10.83654532
77NEK90.82942219
78ATM0.81922051
79PRKCE0.81634169
80MKNK20.81611722
81KDR0.81214874
82AKT30.80752351
83TIE10.78728164
84MAP2K30.78482670
85ADRBK10.78302776
86PRKCG0.77584245
87MUSK0.75183197
88CSNK2A20.74826150
89LRRK20.69369945
90PBK0.67960767
91MST40.67899110
92ERBB30.67822282
93CSNK2A10.67655331
94CDK190.66782081
95PIM20.66140989
96CAMKK20.65317094
97PLK20.65224838
98PHKG10.64165076
99PHKG20.64165076
100SCYL20.63738587
101MAP4K10.62798474
102BRAF0.60599484
103PIM10.59786695
104CDK20.59414362
105STK30.59381684
106PAK30.59103981
107CSNK1A1L0.56024561
108CDK80.55685956
109IKBKB0.54854961
110STK240.54235986
111DAPK20.54052054
112MAP3K110.52173614
113CDK30.50397524
114PKN20.48443594
115PKN10.47941761
116PRKCQ0.47688922
117ITK0.47101124
118CDK10.46042638
119ALK0.45156255
120MAP3K100.44519945
121NTRK20.43191976
122MAP3K120.42798406
123RPS6KA50.41803361
124LIMK10.41386597
125PAK10.41014844
126EIF2AK20.40007685
127MARK10.39428640
128MYLK0.38411089
129NME10.37924213
130ZAP700.37080130
131PRKACA0.36301498
132TEC0.35138911
133BTK0.34927827
134CSNK1A10.34732065
135CDK60.34573913
136LATS10.33631019
137CAMK2A0.33510405
138CCNB10.31880240
139NLK0.31522284
140PNCK0.30480696
141CSNK1E0.30128302
142DYRK20.29644192
143PAK20.28474814
144RPS6KB10.26331824
145OBSCN0.25663752
146TXK0.25578250
147KIT0.25024934
148PRKDC0.24785825
149PRKCI0.24726685
150ERBB40.24217596
151MAPKAPK50.23070226

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.11743488
2Ribosome_Homo sapiens_hsa030103.74866180
3Mismatch repair_Homo sapiens_hsa034303.66184281
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.61294741
5Proteasome_Homo sapiens_hsa030503.36248317
6RNA polymerase_Homo sapiens_hsa030203.21491641
7Spliceosome_Homo sapiens_hsa030402.96725185
8One carbon pool by folate_Homo sapiens_hsa006702.89315151
9RNA transport_Homo sapiens_hsa030132.77574699
10Homologous recombination_Homo sapiens_hsa034402.69273706
11Base excision repair_Homo sapiens_hsa034102.68553665
12Nucleotide excision repair_Homo sapiens_hsa034202.66285980
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.64422445
14Pyrimidine metabolism_Homo sapiens_hsa002402.52835843
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.39734614
16Cell cycle_Homo sapiens_hsa041102.35670408
17Non-homologous end-joining_Homo sapiens_hsa034502.20317285
18Basal transcription factors_Homo sapiens_hsa030222.04517504
19RNA degradation_Homo sapiens_hsa030182.03982535
20Butanoate metabolism_Homo sapiens_hsa006501.99370170
21Phototransduction_Homo sapiens_hsa047441.83993195
22Nitrogen metabolism_Homo sapiens_hsa009101.83658880
23Fanconi anemia pathway_Homo sapiens_hsa034601.72027481
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.71719842
25Selenocompound metabolism_Homo sapiens_hsa004501.64043696
26Protein export_Homo sapiens_hsa030601.61110621
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54761319
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.46553098
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46064262
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.44905999
31Folate biosynthesis_Homo sapiens_hsa007901.39300089
32p53 signaling pathway_Homo sapiens_hsa041151.36236648
33Nicotine addiction_Homo sapiens_hsa050331.33205986
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31336280
35Purine metabolism_Homo sapiens_hsa002301.30382289
36Biosynthesis of amino acids_Homo sapiens_hsa012301.27127729
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.25752232
38mRNA surveillance pathway_Homo sapiens_hsa030151.24562441
39Tryptophan metabolism_Homo sapiens_hsa003801.23764972
40Ether lipid metabolism_Homo sapiens_hsa005651.21398588
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17716802
42Cardiac muscle contraction_Homo sapiens_hsa042601.15829168
43Huntingtons disease_Homo sapiens_hsa050161.15422545
44Parkinsons disease_Homo sapiens_hsa050121.14907324
45Oxidative phosphorylation_Homo sapiens_hsa001901.12269388
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11449790
47Olfactory transduction_Homo sapiens_hsa047401.06878105
48Sulfur relay system_Homo sapiens_hsa041221.06280903
49Pentose phosphate pathway_Homo sapiens_hsa000301.06019656
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00344680
51Epstein-Barr virus infection_Homo sapiens_hsa051690.98937302
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97857303
53Carbon metabolism_Homo sapiens_hsa012000.97831157
54Vitamin B6 metabolism_Homo sapiens_hsa007500.94590840
55Systemic lupus erythematosus_Homo sapiens_hsa053220.94280851
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94031383
57Antigen processing and presentation_Homo sapiens_hsa046120.93725080
58Glutathione metabolism_Homo sapiens_hsa004800.90565760
59Retinol metabolism_Homo sapiens_hsa008300.90479785
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90360165
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.89179436
62Sulfur metabolism_Homo sapiens_hsa009200.88675587
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87451117
64Taste transduction_Homo sapiens_hsa047420.86301370
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84164052
66Fatty acid elongation_Homo sapiens_hsa000620.81403081
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79191526
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.78796057
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.77668323
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76264893
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75644409
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74107852
73Steroid biosynthesis_Homo sapiens_hsa001000.72438743
74Oocyte meiosis_Homo sapiens_hsa041140.72308740
75Viral carcinogenesis_Homo sapiens_hsa052030.68522136
76Pyruvate metabolism_Homo sapiens_hsa006200.66555392
77Thyroid cancer_Homo sapiens_hsa052160.65296944
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63763103
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61571429
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60840979
81Asthma_Homo sapiens_hsa053100.58898161
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58515288
83Morphine addiction_Homo sapiens_hsa050320.58379796
84Herpes simplex infection_Homo sapiens_hsa051680.57963007
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56692429
86Metabolic pathways_Homo sapiens_hsa011000.55610554
87Fat digestion and absorption_Homo sapiens_hsa049750.54083357
88Fructose and mannose metabolism_Homo sapiens_hsa000510.52712866
89Serotonergic synapse_Homo sapiens_hsa047260.52398063
90Galactose metabolism_Homo sapiens_hsa000520.51861315
91ABC transporters_Homo sapiens_hsa020100.48635967
92Primary immunodeficiency_Homo sapiens_hsa053400.47154560
93Propanoate metabolism_Homo sapiens_hsa006400.46811592
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43779758
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43435575
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42523920
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40374969
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.38728771
99Alzheimers disease_Homo sapiens_hsa050100.38449981
100HTLV-I infection_Homo sapiens_hsa051660.37815846
101N-Glycan biosynthesis_Homo sapiens_hsa005100.37399957
102Glycerolipid metabolism_Homo sapiens_hsa005610.35566665
103Histidine metabolism_Homo sapiens_hsa003400.34909941
104Legionellosis_Homo sapiens_hsa051340.34245223
105GABAergic synapse_Homo sapiens_hsa047270.34244046
106Fatty acid metabolism_Homo sapiens_hsa012120.34134529
107Collecting duct acid secretion_Homo sapiens_hsa049660.33903033
108Chemical carcinogenesis_Homo sapiens_hsa052040.32456341
109Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32287979
110Circadian entrainment_Homo sapiens_hsa047130.29430615
111Vitamin digestion and absorption_Homo sapiens_hsa049770.28796129
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27723728
113Peroxisome_Homo sapiens_hsa041460.27430072
114Fatty acid degradation_Homo sapiens_hsa000710.27212755
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27030088
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26898400
117Ovarian steroidogenesis_Homo sapiens_hsa049130.26710133
118Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26052754
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25122298
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24289850
121Arginine and proline metabolism_Homo sapiens_hsa003300.21711477
122Caffeine metabolism_Homo sapiens_hsa002320.21324569
123Hematopoietic cell lineage_Homo sapiens_hsa046400.16255421
124MicroRNAs in cancer_Homo sapiens_hsa052060.13550225
125TGF-beta signaling pathway_Homo sapiens_hsa043500.13196048
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.12380467
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.12269919
128Phenylalanine metabolism_Homo sapiens_hsa003600.11902282
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.11266565
130Small cell lung cancer_Homo sapiens_hsa052220.11097865
131Alcoholism_Homo sapiens_hsa050340.10809118
132Apoptosis_Homo sapiens_hsa042100.10068170
133Tyrosine metabolism_Homo sapiens_hsa003500.09782113
134Linoleic acid metabolism_Homo sapiens_hsa005910.09336469
135Regulation of autophagy_Homo sapiens_hsa041400.09136463
136Arachidonic acid metabolism_Homo sapiens_hsa005900.09102853
137beta-Alanine metabolism_Homo sapiens_hsa004100.09039380

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