WDR83

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.09565837
2ATP synthesis coupled proton transport (GO:0015986)6.64085302
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.64085302
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.48653189
5DNA deamination (GO:0045006)5.45111051
6respiratory electron transport chain (GO:0022904)5.18200965
7proteasome assembly (GO:0043248)5.14496535
8electron transport chain (GO:0022900)5.05054122
9chaperone-mediated protein transport (GO:0072321)5.04775875
10L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.89100703
11behavioral response to nicotine (GO:0035095)4.85131805
12response to pheromone (GO:0019236)4.84853974
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.80102523
14mitochondrial respiratory chain complex I assembly (GO:0032981)4.80102523
15NADH dehydrogenase complex assembly (GO:0010257)4.80102523
16viral transcription (GO:0019083)4.78841691
17ribosomal small subunit assembly (GO:0000028)4.70062142
18ribosomal small subunit biogenesis (GO:0042274)4.68452067
19protein complex biogenesis (GO:0070271)4.67882449
20translational termination (GO:0006415)4.64058575
21cullin deneddylation (GO:0010388)4.52126641
22mitochondrial respiratory chain complex assembly (GO:0033108)4.41018943
23cotranslational protein targeting to membrane (GO:0006613)4.25192210
24protein deneddylation (GO:0000338)4.23879815
25SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.22548959
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.19338054
27L-methionine salvage (GO:0071267)4.18443794
28L-methionine biosynthetic process (GO:0071265)4.18443794
29amino acid salvage (GO:0043102)4.18443794
30protein targeting to ER (GO:0045047)4.16449768
31translational elongation (GO:0006414)4.16062814
32termination of RNA polymerase III transcription (GO:0006386)4.11471827
33transcription elongation from RNA polymerase III promoter (GO:0006385)4.11471827
34regulation of cellular amino acid metabolic process (GO:0006521)4.10261904
35protein-cofactor linkage (GO:0018065)4.09737537
36water-soluble vitamin biosynthetic process (GO:0042364)4.08062087
37oxidative phosphorylation (GO:0006119)4.06355478
38protein localization to endoplasmic reticulum (GO:0070972)4.04582390
39establishment of protein localization to endoplasmic reticulum (GO:0072599)3.96636772
40establishment of protein localization to mitochondrial membrane (GO:0090151)3.95183448
41regulation of mitochondrial translation (GO:0070129)3.90308358
42negative regulation of ligase activity (GO:0051352)3.89718841
43negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.89718841
44maturation of SSU-rRNA (GO:0030490)3.88027107
45iron-sulfur cluster assembly (GO:0016226)3.86133939
46metallo-sulfur cluster assembly (GO:0031163)3.86133939
47positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.80762516
48protein targeting to mitochondrion (GO:0006626)3.80378371
49establishment of protein localization to mitochondrion (GO:0072655)3.76463765
50ribosomal large subunit biogenesis (GO:0042273)3.76299034
51cellular protein complex disassembly (GO:0043624)3.75999232
52DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.75877390
53translational initiation (GO:0006413)3.75141273
54translation (GO:0006412)3.73867297
55peptidyl-histidine modification (GO:0018202)3.73216413
56respiratory chain complex IV assembly (GO:0008535)3.71984975
57viral life cycle (GO:0019058)3.70774944
58intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.68753578
59signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.68753578
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.67420964
61signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.66277568
62signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.66277568
63signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.66277568
64GTP biosynthetic process (GO:0006183)3.64884709
65anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.62270172
66protein neddylation (GO:0045116)3.58484919
67signal transduction involved in DNA damage checkpoint (GO:0072422)3.56535951
68signal transduction involved in DNA integrity checkpoint (GO:0072401)3.56535951
69viral mRNA export from host cell nucleus (GO:0046784)3.55487657
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.55358493
71spliceosomal complex assembly (GO:0000245)3.55003281
72purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.53895733
73preassembly of GPI anchor in ER membrane (GO:0016254)3.53882094
74nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.53394811
75protein localization to mitochondrion (GO:0070585)3.52830436
76purine nucleoside triphosphate biosynthetic process (GO:0009145)3.51439618
77signal transduction involved in cell cycle checkpoint (GO:0072395)3.51355126
78ATP biosynthetic process (GO:0006754)3.50756025
79deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.49819680
80pseudouridine synthesis (GO:0001522)3.49135842
81inner mitochondrial membrane organization (GO:0007007)3.42195197
82base-excision repair, AP site formation (GO:0006285)3.42096643
837-methylguanosine mRNA capping (GO:0006370)3.41549595
84spliceosomal snRNP assembly (GO:0000387)3.40120006
85cellular component biogenesis (GO:0044085)3.39219969
86guanosine-containing compound biosynthetic process (GO:1901070)3.38854814
87quinone biosynthetic process (GO:1901663)3.38773727
88ubiquinone biosynthetic process (GO:0006744)3.38773727
89DNA damage response, detection of DNA damage (GO:0042769)3.36017697
90histone arginine methylation (GO:0034969)3.35426933
91RNA capping (GO:0036260)3.34697588
927-methylguanosine RNA capping (GO:0009452)3.34697588
93RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.34024833
94tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.34024833
95ribonucleoside triphosphate biosynthetic process (GO:0009201)3.33864072
96hydrogen ion transmembrane transport (GO:1902600)3.31508577
97aerobic respiration (GO:0009060)3.30080576
98UTP biosynthetic process (GO:0006228)3.25553759
99regulation of cellular amine metabolic process (GO:0033238)3.23064232
100protein complex disassembly (GO:0043241)3.22285218
101antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.20639923
102CTP biosynthetic process (GO:0006241)3.20321319
103CTP metabolic process (GO:0046036)3.20321319
104ubiquinone metabolic process (GO:0006743)3.19027150
105positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.16955106
106macromolecular complex disassembly (GO:0032984)3.16299850
107ribonucleoprotein complex biogenesis (GO:0022613)3.16001247
108cytochrome complex assembly (GO:0017004)3.15665570
109proton transport (GO:0015992)3.11979834
110pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.11895920
111nonmotile primary cilium assembly (GO:0035058)3.10626390
112mannosylation (GO:0097502)3.10480331
113hydrogen transport (GO:0006818)3.06655189
114cellular ketone body metabolic process (GO:0046950)3.03902418
115positive regulation of mitochondrial fission (GO:0090141)3.02774265
116L-fucose catabolic process (GO:0042355)2.98378740
117fucose catabolic process (GO:0019317)2.98378740
118L-fucose metabolic process (GO:0042354)2.98378740
119rRNA modification (GO:0000154)2.97942549
120platelet dense granule organization (GO:0060155)2.97437001
121nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93931298
122C-terminal protein lipidation (GO:0006501)2.93595827
123tRNA processing (GO:0008033)2.91943278
124negative regulation of telomere maintenance (GO:0032205)2.90602271
125pyrimidine nucleotide catabolic process (GO:0006244)2.86982602
126exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83673778
127C-terminal protein amino acid modification (GO:0018410)2.81589443
128intracellular protein transmembrane import (GO:0044743)2.81086550
129positive regulation of prostaglandin secretion (GO:0032308)2.76859764
130negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.76203021
131energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.75665801
132ATP hydrolysis coupled proton transport (GO:0015991)2.75665801
133protein polyglutamylation (GO:0018095)2.73066911
134tRNA modification (GO:0006400)2.68157095
135mitochondrion morphogenesis (GO:0070584)2.68015461
136maturation of 5.8S rRNA (GO:0000460)2.67352866
137regulation of glucokinase activity (GO:0033131)2.65824209
138regulation of hexokinase activity (GO:1903299)2.65824209
139ketone body metabolic process (GO:1902224)2.64701206
140GPI anchor metabolic process (GO:0006505)2.62788125
141negative regulation of mast cell activation (GO:0033004)2.61849917
142replication fork processing (GO:0031297)2.57894336
143rRNA methylation (GO:0031167)2.55520388
144amine catabolic process (GO:0009310)2.51047505
145cellular biogenic amine catabolic process (GO:0042402)2.51047505
146regulation of nuclear cell cycle DNA replication (GO:0033262)2.48953934
147detection of light stimulus involved in sensory perception (GO:0050962)2.48837856
148detection of light stimulus involved in visual perception (GO:0050908)2.48837856
149GPI anchor biosynthetic process (GO:0006506)2.47823409
150axoneme assembly (GO:0035082)2.45927212
151regulation of cilium movement (GO:0003352)2.45699707
152epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.43768160
153adaptation of signaling pathway (GO:0023058)2.42860459
154inositol phosphate dephosphorylation (GO:0046855)2.41597499
155phosphorylated carbohydrate dephosphorylation (GO:0046838)2.41597499

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.82251394
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.40843321
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.28850662
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.27405782
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.13440318
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.08843446
7MYC_18555785_ChIP-Seq_MESCs_Mouse4.03175549
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.99855876
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.93609892
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.87872838
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.80793636
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.40601908
13ZNF274_21170338_ChIP-Seq_K562_Hela3.35309785
14MYC_18358816_ChIP-ChIP_MESCs_Mouse3.16989383
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.10899657
16THAP11_20581084_ChIP-Seq_MESCs_Mouse3.07982935
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.95464210
18VDR_23849224_ChIP-Seq_CD4+_Human2.71837891
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.67835337
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.67401219
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.62919403
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.62108535
23YY1_21170310_ChIP-Seq_MESCs_Mouse2.57733259
24XRN2_22483619_ChIP-Seq_HELA_Human2.54547235
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50041348
26DCP1A_22483619_ChIP-Seq_HELA_Human2.44465251
27* FOXP3_21729870_ChIP-Seq_TREG_Human2.35629959
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.31626934
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.23744227
30GABP_19822575_ChIP-Seq_HepG2_Human2.22587715
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.19742402
32ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.11005221
33TTF2_22483619_ChIP-Seq_HELA_Human2.01555637
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.99001845
35VDR_22108803_ChIP-Seq_LS180_Human1.96562669
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95636038
37EZH2_22144423_ChIP-Seq_EOC_Human1.88216813
38CIITA_25753668_ChIP-Seq_RAJI_Human1.87953327
39TP53_22573176_ChIP-Seq_HFKS_Human1.81668068
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.81019316
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80375054
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.76967335
43CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.72285602
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.72219980
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71660119
46E2F7_22180533_ChIP-Seq_HELA_Human1.71534253
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69607708
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68953099
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65152813
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63251307
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61328345
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.59781895
53ELK1_19687146_ChIP-ChIP_HELA_Human1.56964771
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56359046
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.56140747
56ERA_21632823_ChIP-Seq_H3396_Human1.51110618
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47229156
58BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.43508871
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43015088
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38090990
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37510209
62ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.35129160
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33905459
64EWS_26573619_Chip-Seq_HEK293_Human1.31720304
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22212893
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.19741899
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19586280
68ELK1_22589737_ChIP-Seq_MCF10A_Human1.17943957
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17291061
70BCL6_27268052_Chip-Seq_Bcells_Human1.16666527
71IGF1R_20145208_ChIP-Seq_DFB_Human1.15638266
72REST_18959480_ChIP-ChIP_MESCs_Mouse1.15146220
73SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15040772
74CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12942159
75NCOR_22424771_ChIP-Seq_293T_Human1.12905338
76REST_21632747_ChIP-Seq_MESCs_Mouse1.12728060
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12297719
78* TAF2_19829295_ChIP-Seq_ESCs_Human1.11974330
79KDM5A_27292631_Chip-Seq_BREAST_Human1.11595534
80ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11499060
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10881162
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10839911
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10767615
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10662058
85MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08967619
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08935165
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08740709
88NANOG_20526341_ChIP-Seq_ESCs_Human1.08717339
89CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08601739
90AR_20517297_ChIP-Seq_VCAP_Human1.08495209
91PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07208242
92* YY1_22570637_ChIP-Seq_MALME-3M_Human1.06598750
93* MYC_19829295_ChIP-Seq_ESCs_Human1.06079347
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05543874
95CTCF_20526341_ChIP-Seq_ESCs_Human1.05128689
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.04520470
97FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04520470
98CBX2_27304074_Chip-Seq_ESCs_Mouse1.04146481
99* E2F1_20622854_ChIP-Seq_HELA_Human1.03951736
100FUS_26573619_Chip-Seq_HEK293_Human1.02796602
101CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01919042
102SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.01008787
103KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00403390
104IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00389779
105ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00038606
106ELF1_20517297_ChIP-Seq_JURKAT_Human0.99913490
107* PHF8_20622854_ChIP-Seq_HELA_Human0.99862565
108MYC_18940864_ChIP-ChIP_HL60_Human0.99385429
109P53_21459846_ChIP-Seq_SAOS-2_Human0.99251980
110CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97365688
111NOTCH1_21737748_ChIP-Seq_TLL_Human0.97096390
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96817605
113GBX2_23144817_ChIP-Seq_PC3_Human0.96033066
114EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95880858
115PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95723875
116CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95085347
117* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94850257
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94657784
119FLI1_27457419_Chip-Seq_LIVER_Mouse0.93015317
120TFEB_21752829_ChIP-Seq_HELA_Human0.92990047
121CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92399475
122FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91340124
123GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90433764
124GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89861622
125ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89475559
126OCT4_20526341_ChIP-Seq_ESCs_Human0.88203703
127RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88001913
128HOXB7_26014856_ChIP-Seq_BT474_Human0.87261631
129SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85558443
130FOXP1_21924763_ChIP-Seq_HESCs_Human0.83251288
131TBX5_21415370_ChIP-Seq_HL-1_Mouse0.82863242
132CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.80942812
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.78738837
134DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.77424116
135HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76100848
136SOX2_18555785_ChIP-Seq_MESCs_Mouse0.75789765
137PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.74798762
138TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.74209591
139SPI1_23547873_ChIP-Seq_NB4_Human0.73791867
140IRF1_19129219_ChIP-ChIP_H3396_Human0.73742127
141VDR_21846776_ChIP-Seq_THP-1_Human0.71458678
142SOX17_20123909_ChIP-Seq_XEN_Mouse0.71077024
143HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.70599402
144GATA1_22383799_ChIP-Seq_G1ME_Mouse0.68523893
145PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.67919711
146* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.67501140

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization3.99005324
2MP0003806_abnormal_nucleotide_metabolis3.73448199
3MP0003880_abnormal_central_pattern3.18996163
4MP0006036_abnormal_mitochondrial_physio3.15914264
5MP0003195_calcinosis2.96144584
6MP0001905_abnormal_dopamine_level2.90326068
7MP0003693_abnormal_embryo_hatching2.79801359
8MP0002837_dystrophic_cardiac_calcinosis2.73101085
9MP0004147_increased_porphyrin_level2.71297961
10MP0004142_abnormal_muscle_tone2.47817503
11MP0004957_abnormal_blastocyst_morpholog2.44498714
12MP0009379_abnormal_foot_pigmentation2.37044997
13MP0006035_abnormal_mitochondrial_morpho2.27544888
14MP0008058_abnormal_DNA_repair2.20183223
15MP0006276_abnormal_autonomic_nervous2.19191388
16MP0006072_abnormal_retinal_apoptosis2.09626584
17MP0003656_abnormal_erythrocyte_physiolo2.07836205
18MP0005551_abnormal_eye_electrophysiolog1.99553210
19MP0002234_abnormal_pharynx_morphology1.94080639
20MP0008260_abnormal_autophagy1.88385215
21MP0003646_muscle_fatigue1.86394127
22MP0008932_abnormal_embryonic_tissue1.84173297
23MP0003186_abnormal_redox_activity1.83480143
24MP0002638_abnormal_pupillary_reflex1.79444223
25MP0003077_abnormal_cell_cycle1.79272294
26MP0000749_muscle_degeneration1.72442540
27MP0002163_abnormal_gland_morphology1.71722988
28MP0008877_abnormal_DNA_methylation1.71529320
29MP0010094_abnormal_chromosome_stability1.70363907
30MP0005646_abnormal_pituitary_gland1.68318756
31MP0005075_abnormal_melanosome_morpholog1.67358576
32MP0003283_abnormal_digestive_organ1.65535403
33MP0001764_abnormal_homeostasis1.63190304
34MP0003787_abnormal_imprinting1.61582478
35MP0006292_abnormal_olfactory_placode1.60783969
36MP0003111_abnormal_nucleus_morphology1.58648421
37MP0002277_abnormal_respiratory_mucosa1.57192999
38MP0003011_delayed_dark_adaptation1.52210812
39MP0005645_abnormal_hypothalamus_physiol1.51773693
40MP0004133_heterotaxia1.49801596
41MP0003329_amyloid_beta_deposits1.48977375
42MP0004742_abnormal_vestibular_system1.48893787
43MP0002736_abnormal_nociception_after1.45480284
44MP0004215_abnormal_myocardial_fiber1.41814130
45MP0004084_abnormal_cardiac_muscle1.41232372
46MP0003718_maternal_effect1.38426450
47MP0000751_myopathy1.38075017
48MP0004043_abnormal_pH_regulation1.37444389
49MP0005253_abnormal_eye_physiology1.36598118
50MP0004036_abnormal_muscle_relaxation1.34268310
51MP0008057_abnormal_DNA_replication1.33155114
52MP0002138_abnormal_hepatobiliary_system1.31864102
53MP0001984_abnormal_olfaction1.28809008
54MP0002876_abnormal_thyroid_physiology1.28762439
55MP0009840_abnormal_foam_cell1.28615746
56MP0002272_abnormal_nervous_system1.28037503
57MP0002064_seizures1.27882524
58MP0005379_endocrine/exocrine_gland_phen1.27771939
59MP0002751_abnormal_autonomic_nervous1.26921507
60MP0005174_abnormal_tail_pigmentation1.26916421
61MP0004145_abnormal_muscle_electrophysio1.25046279
62MP0001502_abnormal_circadian_rhythm1.23441861
63MP0004381_abnormal_hair_follicle1.22098096
64MP0005330_cardiomyopathy1.20912524
65MP0002735_abnormal_chemical_nociception1.18239144
66MP0005389_reproductive_system_phenotype1.17870367
67MP0001986_abnormal_taste_sensitivity1.16037113
68MP0001919_abnormal_reproductive_system1.15773475
69MP0005266_abnormal_metabolism1.14562040
70MP0005084_abnormal_gallbladder_morpholo1.13010679
71MP0001968_abnormal_touch/_nociception1.12800549
72MP0002132_abnormal_respiratory_system1.12335775
73MP0001440_abnormal_grooming_behavior1.11601327
74MP0002160_abnormal_reproductive_system1.10213380
75MP0000631_abnormal_neuroendocrine_gland1.09315710
76MP0009745_abnormal_behavioral_response1.09291814
77MP0008789_abnormal_olfactory_epithelium1.07401864
78MP0003786_premature_aging1.07222803
79MP0002102_abnormal_ear_morphology1.07028026
80MP0000358_abnormal_cell_content/1.06642362
81MP0002693_abnormal_pancreas_physiology1.06396703
82MP0002653_abnormal_ependyma_morphology1.06194209
83MP0004885_abnormal_endolymph1.05771023
84MP0002557_abnormal_social/conspecific_i1.04857932
85MP0008872_abnormal_physiological_respon1.04395279
86MP0002822_catalepsy1.04389396
87MP0003121_genomic_imprinting1.03411106
88MP0005423_abnormal_somatic_nervous1.03391213
89MP0002928_abnormal_bile_duct1.02881462
90MP0000920_abnormal_myelination1.01076843
91MP0000372_irregular_coat_pigmentation1.00904763
92MP0001970_abnormal_pain_threshold0.98762268
93MP0002734_abnormal_mechanical_nocicepti0.98495380
94MP0004924_abnormal_behavior0.98436482
95MP0005386_behavior/neurological_phenoty0.98436482
96MP0003122_maternal_imprinting0.96357421
97MP0005636_abnormal_mineral_homeostasis0.95284155
98MP0000747_muscle_weakness0.95229655
99MP0008995_early_reproductive_senescence0.94564665
100MP0003137_abnormal_impulse_conducting0.94509571
101MP0005671_abnormal_response_to0.93971101
102MP0002067_abnormal_sensory_capabilities0.92137721
103MP0005410_abnormal_fertilization0.91863123
104MP0004270_analgesia0.91323253
105MP0002938_white_spotting0.90623249
106MP0009046_muscle_twitch0.87666282
107MP0002210_abnormal_sex_determination0.87579359
108MP0001485_abnormal_pinna_reflex0.86259694
109MP0001501_abnormal_sleep_pattern0.85651136
110MP0003221_abnormal_cardiomyocyte_apopto0.85201477
111MP0005499_abnormal_olfactory_system0.85090251
112MP0005394_taste/olfaction_phenotype0.85090251
113MP0003315_abnormal_perineum_morphology0.85047351
114MP0002572_abnormal_emotion/affect_behav0.84202185
115MP0002733_abnormal_thermal_nociception0.83683274
116MP0002909_abnormal_adrenal_gland0.82247014
117MP0003635_abnormal_synaptic_transmissio0.81432311
118MP0001727_abnormal_embryo_implantation0.81318294
119MP0001944_abnormal_pancreas_morphology0.81216817
120MP0008875_abnormal_xenobiotic_pharmacok0.80717188
121MP0003698_abnormal_male_reproductive0.80289568
122MP0009333_abnormal_splenocyte_physiolog0.79948692
123MP0010386_abnormal_urinary_bladder0.78051152
124MP0001929_abnormal_gametogenesis0.77536468
125MP0005377_hearing/vestibular/ear_phenot0.77474341
126MP0003878_abnormal_ear_physiology0.77474341
127MP0002396_abnormal_hematopoietic_system0.76836752
128MP0005376_homeostasis/metabolism_phenot0.76578469
129MP0005083_abnormal_biliary_tract0.76474393
130MP0009697_abnormal_copulation0.74690762
131MP0002229_neurodegeneration0.74002997
132MP0000313_abnormal_cell_death0.71982677
133MP0001486_abnormal_startle_reflex0.70667877
134MP0002269_muscular_atrophy0.69786088
135MP0002095_abnormal_skin_pigmentation0.65677183
136MP0001188_hyperpigmentation0.64992039
137MP0001730_embryonic_growth_arrest0.64976009
138MP0000566_synostosis0.64141678
139MP0002066_abnormal_motor_capabilities/c0.62669619
140MP0002063_abnormal_learning/memory/cond0.60935216
141MP0003763_abnormal_thymus_physiology0.60498091
142MP0005584_abnormal_enzyme/coenzyme_acti0.59880823
143* MP0005332_abnormal_amino_acid0.58635189
144MP0003136_yellow_coat_color0.57695804
145MP0005409_darkened_coat_color0.57551706

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.35964345
2Abnormal mitochondria in muscle tissue (HP:0008316)6.15367534
3Hepatocellular necrosis (HP:0001404)6.02963886
4Mitochondrial inheritance (HP:0001427)5.92207208
5Hepatic necrosis (HP:0002605)5.48858005
6Increased CSF lactate (HP:0002490)5.32618941
7Acute encephalopathy (HP:0006846)5.19742438
8Progressive macrocephaly (HP:0004481)5.10184626
9Increased serum pyruvate (HP:0003542)5.03486559
10Abnormality of glycolysis (HP:0004366)5.03486559
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.64737420
12Decreased activity of mitochondrial respiratory chain (HP:0008972)4.64737420
13Increased hepatocellular lipid droplets (HP:0006565)4.14271886
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.14214164
15Increased intramyocellular lipid droplets (HP:0012240)4.13339512
16Increased serum lactate (HP:0002151)4.12542245
17Lactic acidosis (HP:0003128)4.06640054
18Abnormality of cells of the erythroid lineage (HP:0012130)4.02533735
19Abnormal number of erythroid precursors (HP:0012131)3.99862737
20Cerebral edema (HP:0002181)3.94573575
21Cerebral hypomyelination (HP:0006808)3.94556261
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.89361120
233-Methylglutaconic aciduria (HP:0003535)3.86757435
24Lipid accumulation in hepatocytes (HP:0006561)3.86433763
25Exercise intolerance (HP:0003546)3.74442841
26Molar tooth sign on MRI (HP:0002419)3.69740311
27Abnormality of midbrain morphology (HP:0002418)3.69740311
28Leukodystrophy (HP:0002415)3.69012413
29Increased muscle lipid content (HP:0009058)3.64663966
30Respiratory failure (HP:0002878)3.59491256
31Congenital stationary night blindness (HP:0007642)3.55091690
32Renal Fanconi syndrome (HP:0001994)3.47361448
33Pancreatic cysts (HP:0001737)3.34192305
34CNS demyelination (HP:0007305)3.25710911
35Optic disc pallor (HP:0000543)3.14818035
36Emotional lability (HP:0000712)3.10738762
37Respiratory difficulties (HP:0002880)2.97572461
38Macrocytic anemia (HP:0001972)2.94282983
39True hermaphroditism (HP:0010459)2.92362698
40Pancreatic fibrosis (HP:0100732)2.88965624
41Abnormality of the heme biosynthetic pathway (HP:0010472)2.83929484
42Abnormality of alanine metabolism (HP:0010916)2.75844178
43Hyperalaninemia (HP:0003348)2.75844178
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.75844178
45Nephronophthisis (HP:0000090)2.75449472
46Reticulocytopenia (HP:0001896)2.74211966
47Exertional dyspnea (HP:0002875)2.66581159
48Microvesicular hepatic steatosis (HP:0001414)2.64995366
49Ragged-red muscle fibers (HP:0003200)2.63579011
50Neuroendocrine neoplasm (HP:0100634)2.62586250
51CNS hypomyelination (HP:0003429)2.59050293
52Attenuation of retinal blood vessels (HP:0007843)2.57729752
53Abnormal rod and cone electroretinograms (HP:0008323)2.48095343
54Decreased electroretinogram (ERG) amplitude (HP:0000654)2.43147376
55Lethargy (HP:0001254)2.38128089
56Delusions (HP:0000746)2.37586409
57Aplasia/Hypoplasia of the sacrum (HP:0008517)2.36611047
58Type II lissencephaly (HP:0007260)2.36584888
59Gliosis (HP:0002171)2.35358520
60Large for gestational age (HP:0001520)2.34293138
61Pheochromocytoma (HP:0002666)2.34111464
62Pendular nystagmus (HP:0012043)2.32968383
63Gait imbalance (HP:0002141)2.32021992
64Congenital primary aphakia (HP:0007707)2.31263999
65Aplastic anemia (HP:0001915)2.29405703
66Pallor (HP:0000980)2.28819466
67Poor suck (HP:0002033)2.27231749
68Progressive microcephaly (HP:0000253)2.25414599
69Type I transferrin isoform profile (HP:0003642)2.23608848
70Abnormality of the renal cortex (HP:0011035)2.22585234
71Polydipsia (HP:0001959)2.20217213
72Abnormal drinking behavior (HP:0030082)2.20217213
73Chronic hepatic failure (HP:0100626)2.19760456
74Nephrogenic diabetes insipidus (HP:0009806)2.19435392
75Renal cortical cysts (HP:0000803)2.18942682
76Abolished electroretinogram (ERG) (HP:0000550)2.18691029
77Abnormality of renal resorption (HP:0011038)2.15995185
78Abnormality of the renal medulla (HP:0100957)2.13669606
79Sclerocornea (HP:0000647)2.11889002
80Absent rod-and cone-mediated responses on ERG (HP:0007688)2.10861927
81Testicular atrophy (HP:0000029)2.09375800
82Postnatal microcephaly (HP:0005484)2.08897043
83Congenital, generalized hypertrichosis (HP:0004540)2.06002986
84Oral leukoplakia (HP:0002745)2.03247731
85Ketosis (HP:0001946)2.02865165
86Hypothermia (HP:0002045)2.02677200
87Abnormality of dicarboxylic acid metabolism (HP:0010995)2.02426099
88Dicarboxylic aciduria (HP:0003215)2.02426099
89Unsteady gait (HP:0002317)2.02356194
90Glycosuria (HP:0003076)2.00721555
91Abnormality of urine glucose concentration (HP:0011016)2.00721555
92Methylmalonic aciduria (HP:0012120)2.00171776
93Hyperglycinemia (HP:0002154)1.99086808
94Generalized aminoaciduria (HP:0002909)1.98491323
95Cystic liver disease (HP:0006706)1.96662589
96Progressive external ophthalmoplegia (HP:0000590)1.91846091
97X-linked dominant inheritance (HP:0001423)1.89496109
98Birth length less than 3rd percentile (HP:0003561)1.87607015
99Dynein arm defect of respiratory motile cilia (HP:0012255)1.86823457
100Absent/shortened dynein arms (HP:0200106)1.86823457
101Progressive muscle weakness (HP:0003323)1.85722369
102Ketoacidosis (HP:0001993)1.84561599
103Inability to walk (HP:0002540)1.83727396
104Spastic paraparesis (HP:0002313)1.83109177
105Abnormal biliary tract physiology (HP:0012439)1.82943278
106Bile duct proliferation (HP:0001408)1.82943278
107Bony spicule pigmentary retinopathy (HP:0007737)1.81854598
108Retinal dysplasia (HP:0007973)1.80139103
109Myokymia (HP:0002411)1.80015691
110Severe muscular hypotonia (HP:0006829)1.79642729
111Parakeratosis (HP:0001036)1.79604439
112Agitation (HP:0000713)1.77140817
113Colon cancer (HP:0003003)1.76155194
114Abnormal protein glycosylation (HP:0012346)1.75210608
115Abnormal glycosylation (HP:0012345)1.75210608
116Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.75210608
117Abnormal protein N-linked glycosylation (HP:0012347)1.75210608
118Polyuria (HP:0000103)1.75175759
119Hemiparesis (HP:0001269)1.74092269
120Chronic sinusitis (HP:0011109)1.73058962
121Polyphagia (HP:0002591)1.72246076
122Male pseudohermaphroditism (HP:0000037)1.71953787
123Hypoplasia of the pons (HP:0012110)1.70640358
124Anencephaly (HP:0002323)1.69908088
125Hypomagnesemia (HP:0002917)1.69784624
126Neoplasm of head and neck (HP:0012288)1.68454515
127Esophageal neoplasm (HP:0100751)1.68454515
128Blindness (HP:0000618)1.68132986
129Pancytopenia (HP:0001876)1.66576904
130Methylmalonic acidemia (HP:0002912)1.65980060
131Rough bone trabeculation (HP:0100670)1.65174639
132Aplasia/hypoplasia of the uterus (HP:0008684)1.63848592
133Multiple enchondromatosis (HP:0005701)1.63461479
134Opisthotonus (HP:0002179)1.62859967
135Microretrognathia (HP:0000308)1.62378582
136Breast hypoplasia (HP:0003187)1.61397905
137Vomiting (HP:0002013)1.60214909
138Brushfield spots (HP:0001088)1.59172173
139Rhabdomyolysis (HP:0003201)1.58979565
140Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.58885058
141Medial flaring of the eyebrow (HP:0010747)1.57053723
142Palpitations (HP:0001962)1.56518435
143Death in infancy (HP:0001522)1.51897751
144Babinski sign (HP:0003487)1.50986276
145External ophthalmoplegia (HP:0000544)1.49123688
146Abnormality of the pons (HP:0007361)1.49046106
147Carpal bone hypoplasia (HP:0001498)1.48735616
148Neoplasm of the adrenal gland (HP:0100631)1.47417322
149Seborrheic dermatitis (HP:0001051)1.46854624
150Cerebellar atrophy (HP:0001272)1.45570914

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.40890914
2STK164.62067177
3MAP4K24.41041498
4NME23.08029360
5ZAK2.94887905
6TESK22.93777619
7ADRBK22.70881112
8VRK22.67867331
9TSSK62.59091318
10CDK192.50481596
11FRK2.49841236
12SRPK12.42091363
13WEE12.41942363
14MAP3K122.38175984
15WNK32.33258311
16NME12.32322198
17BCKDK2.28691986
18GRK12.27667020
19NUAK12.22614711
20TLK12.02197595
21VRK11.99426204
22EIF2AK11.91817364
23MYLK1.88441835
24PIM21.87266221
25ARAF1.87127710
26EIF2AK31.87017334
27INSRR1.76989315
28NEK11.74942577
29ACVR1B1.73769652
30TXK1.73193371
31UHMK11.58616687
32PINK11.56533847
33CCNB11.54583122
34CASK1.45807045
35BRAF1.40929079
36MAP2K71.40412622
37CDK81.35846117
38TAF11.32312337
39DYRK31.29819232
40PHKG11.26541035
41PHKG21.26541035
42CSNK1G21.24814730
43DAPK21.22171568
44TNIK1.22097156
45TAOK31.21915727
46PNCK1.21581378
47MAPK151.16676300
48CSNK1A1L1.12664119
49IKBKB1.09921385
50STK391.09767166
51MKNK11.07008208
52LIMK11.06127457
53DYRK21.06064357
54BRSK11.05552755
55BRSK21.02845837
56OXSR10.99674944
57OBSCN0.98895089
58AURKA0.98043672
59BMPR1B0.95082668
60MAPKAPK50.94823318
61SIK30.93580197
62DAPK10.91704243
63PRKCG0.89610450
64CAMKK20.89304736
65KDR0.88479645
66CSNK1G30.83680921
67ABL20.83655342
68ILK0.83415735
69ADRBK10.81981945
70PLK40.77798354
71PBK0.75757078
72IRAK40.72689139
73CAMK2B0.72589177
74RPS6KA50.72111655
75DAPK30.70977527
76MAPK40.70942918
77GRK50.70506690
78CDC70.68938662
79MAP2K60.68903845
80IRAK20.68383804
81PRKCQ0.66915969
82MST40.66221651
83MAP3K40.65990559
84TIE10.65493560
85CLK10.65046737
86PLK10.61666373
87PKN10.60617799
88CHUK0.60469816
89BCR0.59592493
90PAK30.59498844
91MATK0.59413336
92CSNK2A20.58985019
93TRIM280.56193528
94PRKCI0.55827104
95MUSK0.55760894
96PAK10.54498771
97TESK10.54446114
98PDK30.54354901
99PDK40.54354901
100CAMK2G0.54353668
101CSNK2A10.53279828
102PLK30.51951302
103BTK0.51468434
104CAMK2D0.50839823
105SYK0.50570492
106PRKCE0.50436654
107MAP3K130.49917312
108MAP4K10.49170804
109PDK20.48849814
110MAP3K110.48799101
111TGFBR10.48561276
112CSNK1A10.47569805
113AURKB0.47543620
114CDK180.47469412
115CDK70.46011131
116GRK60.42792047
117CDK11A0.42369063
118FES0.42133652
119CDK140.41538712
120MKNK20.41483370
121PLK20.41233548
122BLK0.41046725
123CAMK10.40121967
124CDK150.39694712
125MAPK130.39588082
126PRKCZ0.38999880
127ATR0.38975787
128RPS6KB20.38849777
129PRKACA0.38255341
130TAOK20.37227053
131CSNK1G10.35777336
132EPHB20.35451165
133NEK20.35300314
134MARK10.34966066
135ROCK20.34038451
136CAMK2A0.33482647
137GRK70.32518002
138PASK0.31982974
139CHEK20.31046760
140SIK20.30782020
141STK110.28975306
142KIT0.28664734
143PRKCA0.28626400
144WNK40.27713002

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.61342346
2Proteasome_Homo sapiens_hsa030504.52832908
3Ribosome_Homo sapiens_hsa030104.36495537
4Parkinsons disease_Homo sapiens_hsa050124.10286603
5RNA polymerase_Homo sapiens_hsa030203.32079386
6Huntingtons disease_Homo sapiens_hsa050162.90481287
7Alzheimers disease_Homo sapiens_hsa050102.79523141
8DNA replication_Homo sapiens_hsa030302.59656534
9Protein export_Homo sapiens_hsa030602.54456954
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.47857067
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.36960331
12Spliceosome_Homo sapiens_hsa030402.19868835
13Pyrimidine metabolism_Homo sapiens_hsa002402.19499190
14Mismatch repair_Homo sapiens_hsa034302.13203595
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.09848096
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.96609354
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.95071647
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.92650100
19Phototransduction_Homo sapiens_hsa047441.81579346
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.72207220
21Base excision repair_Homo sapiens_hsa034101.71389189
22Fatty acid elongation_Homo sapiens_hsa000621.69942930
23Cardiac muscle contraction_Homo sapiens_hsa042601.69811831
24Nucleotide excision repair_Homo sapiens_hsa034201.68694557
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67323036
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.62321550
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55222476
28RNA transport_Homo sapiens_hsa030131.48642377
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48440187
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42782232
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.41147826
32Sulfur relay system_Homo sapiens_hsa041221.40121455
33Nitrogen metabolism_Homo sapiens_hsa009101.38063094
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36991382
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36728959
36Pyruvate metabolism_Homo sapiens_hsa006201.36436091
37Homologous recombination_Homo sapiens_hsa034401.34281266
38Basal transcription factors_Homo sapiens_hsa030221.29275544
39Purine metabolism_Homo sapiens_hsa002301.25366663
40Carbon metabolism_Homo sapiens_hsa012001.21598983
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.20977959
42Caffeine metabolism_Homo sapiens_hsa002321.19035890
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16230038
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14826861
45Folate biosynthesis_Homo sapiens_hsa007901.14018118
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13297846
47Collecting duct acid secretion_Homo sapiens_hsa049661.12043791
48Tryptophan metabolism_Homo sapiens_hsa003801.09543125
49Steroid biosynthesis_Homo sapiens_hsa001001.04551693
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02402677
51Propanoate metabolism_Homo sapiens_hsa006401.01812406
52Regulation of autophagy_Homo sapiens_hsa041400.96731033
53Biosynthesis of amino acids_Homo sapiens_hsa012300.96648885
54Sulfur metabolism_Homo sapiens_hsa009200.96350469
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95100116
56RNA degradation_Homo sapiens_hsa030180.94221867
57Metabolic pathways_Homo sapiens_hsa011000.94008900
58Asthma_Homo sapiens_hsa053100.89429278
59Vitamin B6 metabolism_Homo sapiens_hsa007500.87465647
60Pentose phosphate pathway_Homo sapiens_hsa000300.86007562
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84698676
62One carbon pool by folate_Homo sapiens_hsa006700.82429127
63Glutathione metabolism_Homo sapiens_hsa004800.77878509
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77799908
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.77254685
66Olfactory transduction_Homo sapiens_hsa047400.76096259
67Non-homologous end-joining_Homo sapiens_hsa034500.75328293
68Type I diabetes mellitus_Homo sapiens_hsa049400.73698468
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70084236
70Vibrio cholerae infection_Homo sapiens_hsa051100.67280694
71Morphine addiction_Homo sapiens_hsa050320.67268011
72Insulin secretion_Homo sapiens_hsa049110.63870567
73Butanoate metabolism_Homo sapiens_hsa006500.62135727
74Epstein-Barr virus infection_Homo sapiens_hsa051690.62097993
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58785064
76Phenylalanine metabolism_Homo sapiens_hsa003600.58704727
77Cell cycle_Homo sapiens_hsa041100.58098652
78Fanconi anemia pathway_Homo sapiens_hsa034600.56493357
79Histidine metabolism_Homo sapiens_hsa003400.56108622
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.55784760
81Arginine and proline metabolism_Homo sapiens_hsa003300.55223483
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52751086
83Peroxisome_Homo sapiens_hsa041460.52629101
84Tyrosine metabolism_Homo sapiens_hsa003500.51532304
85Taste transduction_Homo sapiens_hsa047420.47232286
86Fructose and mannose metabolism_Homo sapiens_hsa000510.42207203
87mRNA surveillance pathway_Homo sapiens_hsa030150.41822898
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40570681
89Synaptic vesicle cycle_Homo sapiens_hsa047210.38593178
90GABAergic synapse_Homo sapiens_hsa047270.38160191
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35650095
92Mineral absorption_Homo sapiens_hsa049780.34428434
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33595488
94Allograft rejection_Homo sapiens_hsa053300.33157092
95beta-Alanine metabolism_Homo sapiens_hsa004100.32846695
96Fat digestion and absorption_Homo sapiens_hsa049750.31290000
97Sphingolipid metabolism_Homo sapiens_hsa006000.31102699
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30123185
99N-Glycan biosynthesis_Homo sapiens_hsa005100.29691763
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.29126451
101Lysosome_Homo sapiens_hsa041420.28515600
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.28474715
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28470057
104ABC transporters_Homo sapiens_hsa020100.28425671
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26684806
106Serotonergic synapse_Homo sapiens_hsa047260.25368069
107Autoimmune thyroid disease_Homo sapiens_hsa053200.25168725
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24878844
109Systemic lupus erythematosus_Homo sapiens_hsa053220.24409171
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23339610
111Primary immunodeficiency_Homo sapiens_hsa053400.23296473
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21688053
113Graft-versus-host disease_Homo sapiens_hsa053320.21324596
114Cocaine addiction_Homo sapiens_hsa050300.20688165
115Salivary secretion_Homo sapiens_hsa049700.19255563
116Fatty acid metabolism_Homo sapiens_hsa012120.18718579
117Ether lipid metabolism_Homo sapiens_hsa005650.18684927
118Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18655737
119Linoleic acid metabolism_Homo sapiens_hsa005910.18460379
120Fatty acid degradation_Homo sapiens_hsa000710.18131028
121Nicotine addiction_Homo sapiens_hsa050330.18051855
122Arachidonic acid metabolism_Homo sapiens_hsa005900.17890179
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15950744
124Alcoholism_Homo sapiens_hsa050340.13713676
125Oocyte meiosis_Homo sapiens_hsa041140.12869961
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.11960624
127Chemical carcinogenesis_Homo sapiens_hsa052040.09611189
128Galactose metabolism_Homo sapiens_hsa000520.09126060
129Selenocompound metabolism_Homo sapiens_hsa004500.06627887
130Primary bile acid biosynthesis_Homo sapiens_hsa001200.05447960
131Phagosome_Homo sapiens_hsa041450.04004606
132Shigellosis_Homo sapiens_hsa051310.02933943
133Rheumatoid arthritis_Homo sapiens_hsa053230.01025933

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