WDR81

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multi-domain transmembrane protein, which is predominantly expressed in the brain. Mutations in this gene are associated with autosomal recessive cerebellar ataxia, mental retardation, and dysequilibrium syndrome-2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.80572615
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.30679959
3L-phenylalanine catabolic process (GO:0006559)4.30679959
4peptidyl-glutamic acid carboxylation (GO:0017187)4.19895047
5protein carboxylation (GO:0018214)4.19895047
6L-phenylalanine metabolic process (GO:0006558)4.16443490
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.16443490
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.14303602
9urea cycle (GO:0000050)4.10730228
10urea metabolic process (GO:0019627)4.10730228
11alpha-linolenic acid metabolic process (GO:0036109)4.06191984
12cysteine metabolic process (GO:0006534)4.01973762
13negative regulation of fibrinolysis (GO:0051918)4.00793025
14aromatic amino acid family catabolic process (GO:0009074)3.97238758
15complement activation, alternative pathway (GO:0006957)3.92396218
16fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.83257499
17negative regulation of cell killing (GO:0031342)3.81809177
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.81809177
19phospholipid homeostasis (GO:0055091)3.80599825
20regulation of cholesterol homeostasis (GO:2000188)3.80157843
21kynurenine metabolic process (GO:0070189)3.71763002
22regulation of interferon-beta biosynthetic process (GO:0045357)3.70719162
23plasma lipoprotein particle clearance (GO:0034381)3.70266618
24low-density lipoprotein particle clearance (GO:0034383)3.69970761
25nitrogen cycle metabolic process (GO:0071941)3.69537796
26regulation of protein activation cascade (GO:2000257)3.68461585
27tryptophan catabolic process (GO:0006569)3.65713954
28indole-containing compound catabolic process (GO:0042436)3.65713954
29indolalkylamine catabolic process (GO:0046218)3.65713954
30response to peptidoglycan (GO:0032494)3.64668184
31sulfur amino acid catabolic process (GO:0000098)3.62811105
32high-density lipoprotein particle remodeling (GO:0034375)3.57494302
33tryptophan metabolic process (GO:0006568)3.56284463
34phospholipid efflux (GO:0033700)3.52743167
35regulation of complement activation (GO:0030449)3.49417189
36regulation of cholesterol storage (GO:0010885)3.49009497
37regulation of fibrinolysis (GO:0051917)3.48756138
38positive thymic T cell selection (GO:0045059)3.43862443
39antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.41883749
40bile acid biosynthetic process (GO:0006699)3.41722309
41homocysteine metabolic process (GO:0050667)3.38761716
42glyoxylate metabolic process (GO:0046487)3.38525273
43modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.37879149
44positive regulation by organism of defense response of other organism involved in symbiotic interact3.37879149
45modulation by symbiont of host immune response (GO:0052553)3.37879149
46positive regulation by symbiont of host defense response (GO:0052509)3.37879149
47modulation by symbiont of host defense response (GO:0052031)3.37879149
48modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.37879149
49detection of other organism (GO:0098543)3.35313014
50protein-lipid complex assembly (GO:0065005)3.35131217
51reverse cholesterol transport (GO:0043691)3.32867358
52plasma lipoprotein particle assembly (GO:0034377)3.30167417
53mannose metabolic process (GO:0006013)3.29059055
54regulation of gamma-delta T cell activation (GO:0046643)3.28798641
55detection of bacterium (GO:0016045)3.27302248
56response to muramyl dipeptide (GO:0032495)3.26711552
57serine family amino acid catabolic process (GO:0009071)3.26665244
58cholesterol efflux (GO:0033344)3.26296194
59negative regulation of sterol transport (GO:0032372)3.23245143
60negative regulation of cholesterol transport (GO:0032375)3.23245143
61lysine metabolic process (GO:0006553)3.19540804
62lysine catabolic process (GO:0006554)3.19540804
63neutrophil activation involved in immune response (GO:0002283)3.18647432
64protein localization to endosome (GO:0036010)3.18567213
65regulation of leukocyte degranulation (GO:0043300)3.15866961
66regulation of triglyceride catabolic process (GO:0010896)3.15796914
67apoptotic cell clearance (GO:0043277)3.13490931
68NIK/NF-kappaB signaling (GO:0038061)3.12879325
69regulation of fatty acid beta-oxidation (GO:0031998)3.12553777
70positive regulation of fatty acid beta-oxidation (GO:0032000)3.12456753
71dicarboxylic acid biosynthetic process (GO:0043650)3.11013643
72barbed-end actin filament capping (GO:0051016)3.10893771
73regulation of myeloid leukocyte mediated immunity (GO:0002886)3.10128316
74regulation of gamma-delta T cell differentiation (GO:0045586)3.09161138
75positive regulation of lipid catabolic process (GO:0050996)3.08834728
76antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.06771244
77antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.06771244
78thymic T cell selection (GO:0045061)3.06450124
79bile acid metabolic process (GO:0008206)3.05683874
80amino-acid betaine metabolic process (GO:0006577)3.03918891
81detection of external biotic stimulus (GO:0098581)3.03654709
82regulation of mast cell degranulation (GO:0043304)3.02919234
83negative regulation of interleukin-12 production (GO:0032695)3.02635120
84macrophage activation involved in immune response (GO:0002281)3.00981395
85plasma lipoprotein particle remodeling (GO:0034369)2.99044894
86protein-lipid complex remodeling (GO:0034368)2.99044894
87macromolecular complex remodeling (GO:0034367)2.99044894
88response to laminar fluid shear stress (GO:0034616)2.98589412
89pinocytosis (GO:0006907)2.96552062
90detection of molecule of bacterial origin (GO:0032490)2.93303455
91bile acid and bile salt transport (GO:0015721)2.91015702
92antigen processing and presentation of endogenous antigen (GO:0019883)2.88584648
93cellular extravasation (GO:0045123)2.88491973
94complement activation, classical pathway (GO:0006958)2.87804174
95regulation of cholesterol esterification (GO:0010872)2.87424850
96positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.86455189
97aromatic amino acid family metabolic process (GO:0009072)2.86438249
98complement activation (GO:0006956)2.85795167
99cholesterol homeostasis (GO:0042632)2.85470550
100sterol homeostasis (GO:0055092)2.83094312
101acylglycerol homeostasis (GO:0055090)2.80556691
102triglyceride homeostasis (GO:0070328)2.80556691
103L-alpha-amino acid transmembrane transport (GO:1902475)2.80263933
104positive regulation of triglyceride metabolic process (GO:0090208)2.79787344
105T cell selection (GO:0045058)2.79390770
106lipoprotein metabolic process (GO:0042157)2.78673431
107tyrosine metabolic process (GO:0006570)2.78651245
108cellular response to thyroid hormone stimulus (GO:0097067)2.78498537
109fibrinolysis (GO:0042730)2.77897772
110protein-lipid complex subunit organization (GO:0071825)2.77604349
111germinal center formation (GO:0002467)2.76210360
112glycine metabolic process (GO:0006544)2.76054876
113cellular modified amino acid catabolic process (GO:0042219)2.75964776
114positive regulation of cholesterol transport (GO:0032376)2.75738394
115positive regulation of sterol transport (GO:0032373)2.75738394
116immunoglobulin mediated immune response (GO:0016064)2.74833051
117positive regulation of B cell differentiation (GO:0045579)2.74548016
118positive regulation of gamma-delta T cell activation (GO:0046645)2.74066125
119positive regulation of triglyceride biosynthetic process (GO:0010867)2.73885534
120positive regulation of hemostasis (GO:1900048)2.72548199
121positive regulation of blood coagulation (GO:0030194)2.72548199
122positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.71525485
123plasma lipoprotein particle organization (GO:0071827)2.70898331
124acute-phase response (GO:0006953)2.68034387
125protein activation cascade (GO:0072376)2.68027232
126glycosphingolipid catabolic process (GO:0046479)2.67651957
127amino sugar catabolic process (GO:0046348)2.67429341
128regulation of mast cell activation involved in immune response (GO:0033006)2.66969219
129modulation by symbiont of host cellular process (GO:0044068)2.65886782
130glutamate metabolic process (GO:0006536)2.64786934
131serine family amino acid metabolic process (GO:0009069)2.64611144
132detection of biotic stimulus (GO:0009595)2.64495480
133regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.64337332
134positive regulation of triglyceride lipase activity (GO:0061365)2.64213406
135positive regulation of lipoprotein lipase activity (GO:0051006)2.64213406
136B cell receptor signaling pathway (GO:0050853)2.64193719
137lipopolysaccharide-mediated signaling pathway (GO:0031663)2.63763398
138negative regulation of granulocyte differentiation (GO:0030853)2.63734780
139negative thymic T cell selection (GO:0045060)2.61520935
140positive regulation of Cdc42 GTPase activity (GO:0043089)2.61337303
141N-acetylneuraminate metabolic process (GO:0006054)2.59854085
142regulation of T-helper 2 cell differentiation (GO:0045628)2.59577743
143positive T cell selection (GO:0043368)2.58221075
144epithelial cell differentiation involved in prostate gland development (GO:0060742)2.52917618
145modulation by virus of host process (GO:0019054)2.52111968
146embryonic process involved in female pregnancy (GO:0060136)2.51982757
147leukocyte aggregation (GO:0070486)2.50955140
148regulation of B cell receptor signaling pathway (GO:0050855)2.48883347
149regulation of extracellular matrix disassembly (GO:0010715)2.47176224
150negative regulation of leukocyte mediated immunity (GO:0002704)2.46340325
151positive regulation of cellular amide metabolic process (GO:0034250)2.43614541
152response to thyroid hormone (GO:0097066)2.43110123
153antigen processing and presentation via MHC class Ib (GO:0002475)2.42715372
154regulation of type I interferon-mediated signaling pathway (GO:0060338)2.42575480
155regulation of T cell tolerance induction (GO:0002664)2.42068444
156regulation of regulated secretory pathway (GO:1903305)2.40790075
157regulation of necroptotic process (GO:0060544)2.40768863
158negative T cell selection (GO:0043383)2.40498422
159myeloid cell activation involved in immune response (GO:0002275)2.37865414
160negative regulation of innate immune response (GO:0045824)2.37822469
161glycolipid catabolic process (GO:0019377)2.36069420
162histone H3-K36 demethylation (GO:0070544)2.35349736
163negative regulation of toll-like receptor signaling pathway (GO:0034122)2.35320299
164response to host immune response (GO:0052572)2.32941009
165response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.32941009
166positive regulation of extracellular matrix organization (GO:1903055)2.32700094
167myeloid dendritic cell differentiation (GO:0043011)2.32439653
168response to host (GO:0075136)2.32041205
169response to host defenses (GO:0052200)2.32041205
170response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.32041205
171regulation of dendritic cell antigen processing and presentation (GO:0002604)2.31924085
172regulation of tolerance induction (GO:0002643)2.31424465
173positive regulation of receptor recycling (GO:0001921)2.30602540
174positive regulation of cholesterol efflux (GO:0010875)2.30426010
175stress fiber assembly (GO:0043149)2.29170017
176negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.28054288
177positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.27717276
178regulation of superoxide anion generation (GO:0032928)2.26825724
179negative regulation of lymphocyte mediated immunity (GO:0002707)2.25886318
180regulation of macrophage cytokine production (GO:0010935)2.24795818
181negative regulation of cytokine production involved in immune response (GO:0002719)2.24692276
182macrophage activation (GO:0042116)2.24632488
183negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.24408656
184regulation of early endosome to late endosome transport (GO:2000641)2.24349575

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.22145688
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.58462745
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.20061031
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.71675634
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.25082394
6EGR1_23403033_ChIP-Seq_LIVER_Mouse2.93659974
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.93616268
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.70324476
9* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.61944709
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.55157138
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.44831795
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.42126390
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.40367287
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27817594
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.25881921
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.25678530
17GATA1_22025678_ChIP-Seq_K562_Human2.25045506
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.22148666
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.21807959
20TP63_17297297_ChIP-ChIP_HaCaT_Human2.16182953
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.15549883
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.12910064
23MYC_22102868_ChIP-Seq_BL_Human2.11407587
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.03029947
25* VDR_21846776_ChIP-Seq_THP-1_Human1.98908192
26BRD4_27068464_Chip-Seq_AML-cells_Mouse1.96398612
27MYB_21317192_ChIP-Seq_ERMYB_Mouse1.88094577
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81760718
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.78231136
30TCF7_22412390_ChIP-Seq_EML_Mouse1.77246907
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.73751359
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.72346760
33SCL_19346495_ChIP-Seq_HPC-7_Human1.71598148
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.71554028
35* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70718332
36STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.68832320
37GATA1_19941826_ChIP-Seq_K562_Human1.66459786
38CLOCK_20551151_ChIP-Seq_293T_Human1.65787332
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62966986
40GATA1_19941827_ChIP-Seq_MEL_Mouse1.62658192
41MAF_26560356_Chip-Seq_TH1_Human1.60791223
42* KDM2B_26808549_Chip-Seq_DND41_Human1.60010487
43* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57514793
44* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.57376252
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.57367239
46LXR_22292898_ChIP-Seq_THP-1_Human1.53102174
47SPI1_23127762_ChIP-Seq_K562_Human1.50302368
48TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.49463480
49TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49285640
50* VDR_24763502_ChIP-Seq_THP-1_Human1.47643777
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.45640840
52CTCF_27219007_Chip-Seq_ERYTHROID_Human1.43378400
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40735510
54UTX_26944678_Chip-Seq_JUKART_Human1.36881254
55PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34388651
56TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.33361250
57* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32537063
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.32380614
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30404201
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30327710
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.30141327
62GATA2_19941826_ChIP-Seq_K562_Human1.29082922
63FOXA2_19822575_ChIP-Seq_HepG2_Human1.28854453
64P68_20966046_ChIP-Seq_HELA_Human1.28813162
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27944783
66RUNX1_22412390_ChIP-Seq_EML_Mouse1.27746706
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27569547
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27506850
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.23534845
70* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22594314
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22049061
72ELF1_20517297_ChIP-Seq_JURKAT_Human1.21565875
73* RACK7_27058665_Chip-Seq_MCF-7_Human1.20785851
74EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19241786
75CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18989088
76SMC4_20622854_ChIP-Seq_HELA_Human1.18288770
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17988696
78IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17675825
79FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.17022466
80BP1_19119308_ChIP-ChIP_Hs578T_Human1.17003833
81UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16990624
82* BCOR_27268052_Chip-Seq_Bcells_Human1.16482414
83STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16069970
84P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15722496
85* MYB_26560356_Chip-Seq_TH1_Human1.14975298
86RUNX_20019798_ChIP-Seq_JUKART_Human1.13511414
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10860619
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10209101
89SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09484800
90TET1_21451524_ChIP-Seq_MESCs_Mouse1.09069673
91PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08882670
92NCOR1_26117541_ChIP-Seq_K562_Human1.08284077
93FOXO3_23340844_ChIP-Seq_DLD1_Human1.08069394
94STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.07935827
95FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.06285411
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05703847
97* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04717987
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04522991
99* BCL6_27268052_Chip-Seq_Bcells_Human1.04377263
100MYB_26560356_Chip-Seq_TH2_Human1.04170887
101RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03181556
102CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03181085
103CREB1_26743006_Chip-Seq_LNCaP_Human1.02672867
104RUNX1_27514584_Chip-Seq_MCF-7_Human1.01170853
105MAF_26560356_Chip-Seq_TH2_Human1.00274999
106* PU_27001747_Chip-Seq_BMDM_Mouse0.99677616
107* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99144078
108KDM2B_26808549_Chip-Seq_JURKAT_Human0.98956882
109TP53_22127205_ChIP-Seq_IMR90_Human0.97819248
110GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97436859
111DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97417610
112SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97011232
113* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96164902
114ATF3_27146783_Chip-Seq_COLON_Human0.95299426
115SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94717098
116GATA2_21666600_ChIP-Seq_HMVEC_Human0.94236674
117HNF4A_19822575_ChIP-Seq_HepG2_Human0.94168119
118* SPI1_23547873_ChIP-Seq_NB4_Human0.93089936
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.91311709
120KDM2B_26808549_Chip-Seq_K562_Human0.90930217
121HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90733665
122SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90271493
123ZNF263_19887448_ChIP-Seq_K562_Human0.90229616
124* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90164856
125PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89896843
126* VDR_24787735_ChIP-Seq_THP-1_Human0.87939076

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.51400189
2MP0002139_abnormal_hepatobiliary_system4.48951590
3MP0009840_abnormal_foam_cell3.84148808
4MP0005365_abnormal_bile_salt3.54534902
5MP0005085_abnormal_gallbladder_physiolo3.34501616
6MP0003191_abnormal_cellular_cholesterol3.02148297
7MP0005058_abnormal_lysosome_morphology3.00525637
8MP0003252_abnormal_bile_duct2.97763989
9MP0003705_abnormal_hypodermis_morpholog2.65898356
10MP0005083_abnormal_biliary_tract2.55747280
11MP0008875_abnormal_xenobiotic_pharmacok2.40501344
12MP0008260_abnormal_autophagy2.37518158
13MP0010329_abnormal_lipoprotein_level2.34237381
14MP0003303_peritoneal_inflammation2.29873702
15MP0003656_abnormal_erythrocyte_physiolo2.16926836
16MP0003300_gastrointestinal_ulcer2.12007757
17MP0003172_abnormal_lysosome_physiology1.96646377
18MP0003436_decreased_susceptibility_to1.94240603
19MP0000609_abnormal_liver_physiology1.94086731
20MP0002138_abnormal_hepatobiliary_system1.90117266
21MP0001835_abnormal_antigen_presentation1.89359045
22MP0003763_abnormal_thymus_physiology1.87989994
23MP0005464_abnormal_platelet_physiology1.83080987
24MP0004381_abnormal_hair_follicle1.72475949
25MP0006082_CNS_inflammation1.68522925
26MP0000569_abnormal_digit_pigmentation1.67263573
27MP0003806_abnormal_nucleotide_metabolis1.65788425
28MP0001790_abnormal_immune_system1.55021278
29MP0005387_immune_system_phenotype1.55021278
30MP0000604_amyloidosis1.52846334
31MP0002419_abnormal_innate_immunity1.52786609
32MP0003828_pulmonary_edema1.52770143
33MP0000685_abnormal_immune_system1.51586049
34MP0000858_altered_metastatic_potential1.51388200
35MP0005332_abnormal_amino_acid1.51025939
36MP0001849_ear_inflammation1.50336210
37MP0002148_abnormal_hypersensitivity_rea1.50108469
38MP0002118_abnormal_lipid_homeostasis1.48606242
39MP0002166_altered_tumor_susceptibility1.47222553
40MP0004947_skin_inflammation1.44505428
41MP0008438_abnormal_cutaneous_collagen1.40742440
42MP0001800_abnormal_humoral_immune1.38745934
43MP0005409_darkened_coat_color1.38637894
44MP0001666_abnormal_nutrient_absorption1.38470905
45MP0003566_abnormal_cell_adhesion1.36311849
46MP0009278_abnormal_bone_marrow1.36240521
47MP0005319_abnormal_enzyme/_coenzyme1.35589993
48MP0003195_calcinosis1.34772813
49MP0002452_abnormal_antigen_presenting1.28486015
50MP0008469_abnormal_protein_level1.28257793
51MP0005451_abnormal_body_composition1.26430110
52MP0002396_abnormal_hematopoietic_system1.24974888
53MP0005000_abnormal_immune_tolerance1.22175176
54MP0005257_abnormal_intraocular_pressure1.21772964
55MP0000598_abnormal_liver_morphology1.21396692
56MP0004510_myositis1.21146536
57MP0000015_abnormal_ear_pigmentation1.20685673
58MP0005076_abnormal_cell_differentiation1.17540682
59MP0004185_abnormal_adipocyte_glucose1.16855154
60MP0005025_abnormal_response_to1.16731238
61MP0000343_altered_response_to1.15736267
62MP0002723_abnormal_immune_serum1.14958557
63MP0001873_stomach_inflammation1.14689784
64MP0004019_abnormal_vitamin_homeostasis1.13504653
65MP0005397_hematopoietic_system_phenotyp1.12900981
66MP0001545_abnormal_hematopoietic_system1.12900981
67MP0009643_abnormal_urine_homeostasis1.12523865
68MP0005670_abnormal_white_adipose1.08901736
69MP0001533_abnormal_skeleton_physiology1.07512084
70MP0001845_abnormal_inflammatory_respons1.05788647
71MP0009764_decreased_sensitivity_to1.05738433
72MP0009763_increased_sensitivity_to1.04329618
73MP0002928_abnormal_bile_duct1.03414874
74MP0001851_eye_inflammation1.03038323
75MP0004130_abnormal_muscle_cell1.02654285
76MP0004808_abnormal_hematopoietic_stem1.01923067
77MP0005584_abnormal_enzyme/coenzyme_acti1.01580144
78MP0010307_abnormal_tumor_latency1.01073014
79MP0003075_altered_response_to1.01061517
80MP0003690_abnormal_glial_cell1.00801283
81MP0001853_heart_inflammation1.00045973
82MP0000689_abnormal_spleen_morphology0.99884341
83MP0005023_abnormal_wound_healing0.99841046
84MP0003329_amyloid_beta_deposits0.99754195
85MP0001819_abnormal_immune_cell0.99493214
86MP0002420_abnormal_adaptive_immunity0.98930259
87MP0004858_abnormal_nervous_system0.98283751
88MP0005671_abnormal_response_to0.97517156
89MP0003183_abnormal_peptide_metabolism0.97359525
90MP0003868_abnormal_feces_composition0.96997897
91MP0003091_abnormal_cell_migration0.96560335
92MP0002933_joint_inflammation0.96525857
93MP0002254_reproductive_system_inflammat0.96389225
94MP0003448_altered_tumor_morphology0.96378545
95MP0002132_abnormal_respiratory_system0.95772697
96MP0000703_abnormal_thymus_morphology0.95075233
97MP0005666_abnormal_adipose_tissue0.90825874
98MP0000465_gastrointestinal_hemorrhage0.90767420
99MP0003866_abnormal_defecation0.87314173
100MP0005166_decreased_susceptibility_to0.87125026
101MP0000767_abnormal_smooth_muscle0.86859926
102MP0000716_abnormal_immune_system0.85600046
103MP0002006_tumorigenesis0.85355935
104MP0010352_gastrointestinal_tract_polyps0.85235465
105MP0002398_abnormal_bone_marrow0.85222830
106MP0004883_abnormal_blood_vessel0.85080725
107MP0003453_abnormal_keratinocyte_physiol0.83379622
108MP0000249_abnormal_blood_vessel0.83266732
109MP0002136_abnormal_kidney_physiology0.82567786
110MP0009785_altered_susceptibility_to0.81957591
111MP0002722_abnormal_immune_system0.81746784
112MP0002405_respiratory_system_inflammati0.81158010
113MP0005390_skeleton_phenotype0.79420130
114MP0003795_abnormal_bone_structure0.79304494
115MP0005164_abnormal_response_to0.78004677
116MP0001958_emphysema0.77872618
117MP0009333_abnormal_splenocyte_physiolog0.77272400
118MP0003045_fibrosis0.77210139
119MP0002998_abnormal_bone_remodeling0.76318483
120MP0003724_increased_susceptibility_to0.75611039
121MP0002429_abnormal_blood_cell0.74205761
122MP0002877_abnormal_melanocyte_morpholog0.73488232
123MP0005310_abnormal_salivary_gland0.72856801
124MP0003279_aneurysm0.72394637
125MP0001756_abnormal_urination0.71891670
126MP0009642_abnormal_blood_homeostasis0.70451849
127MP0000371_diluted_coat_color0.70151115
128MP0010155_abnormal_intestine_physiology0.70083622
129MP0001915_intracranial_hemorrhage0.69998379
130MP0002971_abnormal_brown_adipose0.69365061
131MP0005334_abnormal_fat_pad0.69281674

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.75405643
2Complement deficiency (HP:0004431)4.41970912
3Xanthomatosis (HP:0000991)4.25828655
4Systemic lupus erythematosus (HP:0002725)4.02624668
5Myocardial infarction (HP:0001658)3.92577650
6Abnormality of monocarboxylic acid metabolism (HP:0010996)3.65936563
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.65624045
8Intrahepatic cholestasis (HP:0001406)3.55030901
9Abnormality of complement system (HP:0005339)3.46127986
10Joint hemorrhage (HP:0005261)3.32830782
11Hyperlipoproteinemia (HP:0010980)3.30018500
12Glomerulonephritis (HP:0000099)3.29576719
13Recurrent gram-negative bacterial infections (HP:0005420)3.27055803
14Prolonged partial thromboplastin time (HP:0003645)3.23862145
15Abnormality of the common coagulation pathway (HP:0010990)2.93668737
16Increased cerebral lipofuscin (HP:0011813)2.93618804
17Axonal loss (HP:0003447)2.91339022
18Hypercholesterolemia (HP:0003124)2.89262903
19Recurrent bacterial skin infections (HP:0005406)2.84778273
20Autoimmune thrombocytopenia (HP:0001973)2.82814289
21Dysostosis multiplex (HP:0000943)2.81239583
22Spontaneous hematomas (HP:0007420)2.78465715
23Abnormality of glutamine family amino acid metabolism (HP:0010902)2.76166287
24Mitral stenosis (HP:0001718)2.75641485
25Hypobetalipoproteinemia (HP:0003563)2.75252537
26Cerebral aneurysm (HP:0004944)2.71167120
27Urinary glycosaminoglycan excretion (HP:0003541)2.70703837
28Mucopolysacchariduria (HP:0008155)2.70703837
29Hypoalphalipoproteinemia (HP:0003233)2.69954085
30Abnormality of polysaccharide metabolism (HP:0011012)2.66448816
31Abnormality of glycosaminoglycan metabolism (HP:0004371)2.66448816
32Abnormality of mucopolysaccharide metabolism (HP:0011020)2.66448816
33Vertebral compression fractures (HP:0002953)2.66057493
34Epidermoid cyst (HP:0200040)2.64429323
35Abnormality of sulfur amino acid metabolism (HP:0004339)2.64289176
36Gingival bleeding (HP:0000225)2.64256813
37Vacuolated lymphocytes (HP:0001922)2.60078521
38Eczematoid dermatitis (HP:0000976)2.59402556
39Polycythemia (HP:0001901)2.58359320
40Recurrent abscess formation (HP:0002722)2.57367490
41Gingivitis (HP:0000230)2.55893381
42Hypolipoproteinemia (HP:0010981)2.51805681
43Reticulocytosis (HP:0001923)2.46500655
44Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.42748803
45Poikilocytosis (HP:0004447)2.42580815
46Nephritis (HP:0000123)2.40823312
47Abnormality of liposaccharide metabolism (HP:0010968)2.39640817
48Abnormality of glycosphingolipid metabolism (HP:0004343)2.39640817
49Abnormality of glycolipid metabolism (HP:0010969)2.39640817
50Mediastinal lymphadenopathy (HP:0100721)2.38915526
51Myositis (HP:0100614)2.37434427
52Colitis (HP:0002583)2.37351417
53Gastrointestinal inflammation (HP:0004386)2.37284880
54Amyloidosis (HP:0011034)2.33148523
55Increased IgE level (HP:0003212)2.33080750
56Recurrent fungal infections (HP:0002841)2.30989735
57Osteolytic defects of the phalanges of the hand (HP:0009771)2.30043373
58Osteolytic defects of the hand bones (HP:0009699)2.30043373
59Peritonitis (HP:0002586)2.30039263
60Broad face (HP:0000283)2.29813820
61Purpura (HP:0000979)2.29109769
62Increased connective tissue (HP:0009025)2.26721309
63Increased neuronal autofluorescent lipopigment (HP:0002074)2.25093552
64Obstructive lung disease (HP:0006536)2.24122718
65Chronic obstructive pulmonary disease (HP:0006510)2.24122718
66Pustule (HP:0200039)2.24031895
67Acanthocytosis (HP:0001927)2.23966280
68Abnormality of the intrinsic pathway (HP:0010989)2.23308762
69Hyperammonemia (HP:0001987)2.23258819
70Thin bony cortex (HP:0002753)2.21961621
71Hepatocellular carcinoma (HP:0001402)2.20219226
72Hemorrhage of the eye (HP:0011885)2.19057605
73Obstructive sleep apnea (HP:0002870)2.17625289
74Menorrhagia (HP:0000132)2.14549608
75Hyperglycinemia (HP:0002154)2.13876919
76Abnormal platelet function (HP:0011869)2.13693658
77Impaired platelet aggregation (HP:0003540)2.13693658
78Esophageal varix (HP:0002040)2.13539169
79Skin nodule (HP:0200036)2.12842136
80Meningitis (HP:0001287)2.11024604
81Abnormality of iron homeostasis (HP:0011031)2.11010749
82Gastrointestinal infarctions (HP:0005244)2.08731070
83Ketosis (HP:0001946)2.08482835
84Chronic mucocutaneous candidiasis (HP:0002728)2.06839737
85Recurrent cutaneous fungal infections (HP:0011370)2.06839737
86Protrusio acetabuli (HP:0003179)2.04080622
87Increased serum ferritin (HP:0003281)2.03105297
88Hyperglycinuria (HP:0003108)2.02917103
89Epistaxis (HP:0000421)2.02347054
90Orchitis (HP:0100796)2.00998359
91Abnormality of macrophages (HP:0004311)2.00428863
92Fat malabsorption (HP:0002630)1.99706033
93Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.99695496
94Abnormality of purine metabolism (HP:0004352)1.99472201
95Osteomyelitis (HP:0002754)1.99265806
96Prolonged bleeding time (HP:0003010)1.99061186
97Upper motor neuron abnormality (HP:0002127)1.98982708
98Hematochezia (HP:0002573)1.97590521
99Abnormality of the fingertips (HP:0001211)1.97455804
100Peripheral demyelination (HP:0011096)1.96634261
101Recurrent skin infections (HP:0001581)1.96227807
102Spondylolisthesis (HP:0003302)1.96039508
103Abnormality of serine family amino acid metabolism (HP:0010894)1.95243787
104Abnormality of glycine metabolism (HP:0010895)1.95243787
105Abnormality of transition element cation homeostasis (HP:0011030)1.93119593
106Asymmetric septal hypertrophy (HP:0001670)1.93011179
107Spastic diplegia (HP:0001264)1.92709999
108Distal lower limb amyotrophy (HP:0008944)1.92592949
109Abnormality of nucleobase metabolism (HP:0010932)1.92534743
110Interstitial pulmonary disease (HP:0006530)1.92477120
111Cervical subluxation (HP:0003308)1.91420960
112Centrally nucleated skeletal muscle fibers (HP:0003687)1.91319252
113Neurofibrillary tangles (HP:0002185)1.91192517
114Loss of speech (HP:0002371)1.90924519
115Polygenic inheritance (HP:0010982)1.90419129
116Mitral valve prolapse (HP:0001634)1.89084666
117Periodontitis (HP:0000704)1.88436757
118Hypochromic microcytic anemia (HP:0004840)1.88194291
119Malnutrition (HP:0004395)1.88016376
120Distal lower limb muscle weakness (HP:0009053)1.88012149
121Abnormality of the nasal mucosa (HP:0000433)1.87864600
122Cholelithiasis (HP:0001081)1.87705702
123Hyperacusis (HP:0010780)1.87412808
124Hyperbilirubinemia (HP:0002904)1.87148246
125Abnormal platelet volume (HP:0011876)1.87025040
126Cerebral inclusion bodies (HP:0100314)1.86652647
127Cellulitis (HP:0100658)1.85488052
128Abnormal delayed hypersensitivity skin test (HP:0002963)1.85448518
129Pathologic fracture (HP:0002756)1.84626677
130Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.84522453
131Increased mean platelet volume (HP:0011877)1.84252856
132Hypertriglyceridemia (HP:0002155)1.84240259
133Emphysema (HP:0002097)1.84192371
134Recurrent viral infections (HP:0004429)1.84090330
135Inflammation of the large intestine (HP:0002037)1.83803826
136Neuronal loss in central nervous system (HP:0002529)1.82861885
137Abnormality of aspartate family amino acid metabolism (HP:0010899)1.82575202
138Aneurysm (HP:0002617)1.82536528
139Hydroxyprolinuria (HP:0003080)1.81861174
140Abnormality of proline metabolism (HP:0010907)1.81861174
141Hypoglycemic coma (HP:0001325)1.79966751
142Premature rupture of membranes (HP:0001788)1.79799271
143Increased variability in muscle fiber diameter (HP:0003557)1.79729538
144Bone pain (HP:0002653)1.78987376
145Dilatation of the ascending aorta (HP:0005111)1.77002113
146J-shaped sella turcica (HP:0002680)1.75433396
147Elevated erythrocyte sedimentation rate (HP:0003565)1.75258165
148Restrictive lung disease (HP:0002091)1.74648524
149Joint stiffness (HP:0001387)1.74347040
150Vasculitis (HP:0002633)1.74275415
151Gastrointestinal stroma tumor (HP:0100723)1.72124421
152Slow saccadic eye movements (HP:0000514)1.69026291
153Petechiae (HP:0000967)1.68881314
154Ocular albinism (HP:0001107)1.68463280
155Urticaria (HP:0001025)1.67392590

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.02579712
2PRPF4B3.85489038
3ERN13.75122835
4PKN22.96804010
5TAOK32.94853963
6MAP4K12.55928761
7SIK12.50451795
8SMG12.46511472
9MAP3K102.41782617
10TYK22.36722728
11CAMK1D2.18688854
12TGFBR22.15819889
13PTK62.12670668
14FGFR42.09129598
15TBK12.08417429
16CDK121.94057875
17CSF1R1.89797404
18EEF2K1.80037467
19JAK11.77583737
20EPHB11.75983705
21CAMK1G1.60844674
22BLK1.58659985
23TTN1.57942631
24MAP3K111.54601191
25RIPK41.53452118
26TAOK21.49310083
27MAP2K31.44652934
28STK101.41189314
29GRK61.37886902
30CDC42BPA1.37598383
31MAP3K141.36970948
32SIK21.34869388
33KIT1.34564248
34IRAK31.33863849
35JAK31.32445238
36JAK21.31325642
37MARK21.29714862
38PRKD21.28110747
39ZAP701.27208407
40NME21.25971435
41MAP3K11.25937736
42BCKDK1.24351632
43TNK21.22812004
44CSK1.20055552
45ICK1.19616741
46RIPK11.19077028
47IKBKB1.13627909
48HCK1.07510724
49CDK61.06734580
50MAPK111.05511200
51MAP3K131.03148961
52BMX1.01927676
53SCYL20.99925152
54LRRK20.98717572
55TAOK10.98064080
56MTOR0.94427046
57HIPK20.92711293
58RPS6KA20.89236838
59CHUK0.89223592
60RPS6KA40.88127373
61PDGFRA0.86573439
62SYK0.86350177
63CDK40.84791223
64STK30.83642875
65IKBKE0.83508745
66MAP3K70.83214597
67SIK30.82277261
68MAP3K60.82029896
69PAK40.80920843
70RPS6KC10.80741529
71RPS6KL10.80741529
72FLT30.79630574
73PTK20.75362826
74PDPK10.73486323
75DDR20.73383935
76ITK0.73300251
77PDGFRB0.73021844
78STK40.72158417
79MAPK70.71300331
80MAP3K30.70837087
81PIM10.69408635
82BTK0.68379236
83IRAK40.68053015
84MAP3K80.66582422
85NEK90.64965751
86LATS10.64696974
87ABL20.62528529
88TESK20.61509742
89LCK0.61285290
90KSR20.60938177
91PDK10.60852932
92PRKAA20.60161812
93IRAK20.59813189
94RPS6KA60.59610000
95FGR0.59430877
96MST1R0.58118999
97SGK30.57486074
98FES0.57361372
99RET0.57109595
100MARK30.56963213
101EGFR0.56908637
102LYN0.56248164
103NEK20.55610147
104MAP3K90.54895113
105DYRK1B0.53818169
106PAK20.53769379
107PRKCH0.53587134
108DAPK20.53349828
109ALK0.52149369
110ABL10.49815679
111MAPK120.48070613
112PRKAA10.47585258
113FGFR30.46795721
114MAP2K20.46336717
115CAMKK10.44858326
116MATK0.41868770
117MELK0.39313730
118MAP3K20.38894376
119MAPKAPK20.37828005
120PRKD30.37557746
121TESK10.36666972
122INSRR0.35761729
123CAMK40.35532423
124GSK3A0.34054254
125TRPM70.33064183
126PRKD10.32351374
127INSR0.30627372
128STK110.30319503

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.37088967
2Nitrogen metabolism_Homo sapiens_hsa009103.30184779
3Staphylococcus aureus infection_Homo sapiens_hsa051503.17287685
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.09457420
5Complement and coagulation cascades_Homo sapiens_hsa046102.76844963
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.68549592
7Arginine biosynthesis_Homo sapiens_hsa002202.48788947
8Caffeine metabolism_Homo sapiens_hsa002322.14930414
9Tryptophan metabolism_Homo sapiens_hsa003802.00533115
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.91230916
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.85149777
12Fatty acid degradation_Homo sapiens_hsa000711.84329500
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.83030051
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.70370133
15PPAR signaling pathway_Homo sapiens_hsa033201.65673668
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62931295
17ABC transporters_Homo sapiens_hsa020101.53047790
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.51020542
19Lysosome_Homo sapiens_hsa041421.47421138
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40737337
21Notch signaling pathway_Homo sapiens_hsa043301.35488648
22Lysine degradation_Homo sapiens_hsa003101.34451833
23Allograft rejection_Homo sapiens_hsa053301.32488575
24B cell receptor signaling pathway_Homo sapiens_hsa046621.32125620
25Bile secretion_Homo sapiens_hsa049761.31641492
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.31294828
27Peroxisome_Homo sapiens_hsa041461.28307286
28Histidine metabolism_Homo sapiens_hsa003401.25490077
29Graft-versus-host disease_Homo sapiens_hsa053321.25320772
30Osteoclast differentiation_Homo sapiens_hsa043801.24986476
31Autoimmune thyroid disease_Homo sapiens_hsa053201.23359766
32Fatty acid metabolism_Homo sapiens_hsa012121.23165693
33Selenocompound metabolism_Homo sapiens_hsa004501.21838470
34T cell receptor signaling pathway_Homo sapiens_hsa046601.20914575
35VEGF signaling pathway_Homo sapiens_hsa043701.19531146
36Vitamin B6 metabolism_Homo sapiens_hsa007501.14093368
37beta-Alanine metabolism_Homo sapiens_hsa004101.13629574
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12909447
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11213905
40Leishmaniasis_Homo sapiens_hsa051401.10884251
41Butanoate metabolism_Homo sapiens_hsa006501.09615737
42Viral myocarditis_Homo sapiens_hsa054161.08852277
43Sulfur relay system_Homo sapiens_hsa041221.08804290
44Bladder cancer_Homo sapiens_hsa052191.08338249
45Phagosome_Homo sapiens_hsa041451.07462668
46Other glycan degradation_Homo sapiens_hsa005111.07144568
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06883662
48Neurotrophin signaling pathway_Homo sapiens_hsa047221.05056528
49Renal cell carcinoma_Homo sapiens_hsa052111.00220856
50Chemical carcinogenesis_Homo sapiens_hsa052040.98997156
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98937106
52Herpes simplex infection_Homo sapiens_hsa051680.98473660
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98438726
54Endometrial cancer_Homo sapiens_hsa052130.98396411
55Primary immunodeficiency_Homo sapiens_hsa053400.96653142
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96226422
57Starch and sucrose metabolism_Homo sapiens_hsa005000.94628848
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92755421
59Chronic myeloid leukemia_Homo sapiens_hsa052200.92414441
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.91182253
61Platelet activation_Homo sapiens_hsa046110.91142597
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.91089218
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90777977
64Insulin resistance_Homo sapiens_hsa049310.89562434
65Phenylalanine metabolism_Homo sapiens_hsa003600.88933392
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.87700410
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.86846993
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85288340
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84630305
70GnRH signaling pathway_Homo sapiens_hsa049120.83599132
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83512154
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82561567
73Folate biosynthesis_Homo sapiens_hsa007900.82220274
74Asthma_Homo sapiens_hsa053100.80760952
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.80435449
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.79644879
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.79571427
78Prolactin signaling pathway_Homo sapiens_hsa049170.79348241
79Fat digestion and absorption_Homo sapiens_hsa049750.78446085
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78211899
81Salmonella infection_Homo sapiens_hsa051320.74650250
82Retinol metabolism_Homo sapiens_hsa008300.74458115
83Rheumatoid arthritis_Homo sapiens_hsa053230.74448626
84Tuberculosis_Homo sapiens_hsa051520.73534667
85Prion diseases_Homo sapiens_hsa050200.72752891
86HTLV-I infection_Homo sapiens_hsa051660.72417717
87Glioma_Homo sapiens_hsa052140.71721060
88Fructose and mannose metabolism_Homo sapiens_hsa000510.70799473
89Choline metabolism in cancer_Homo sapiens_hsa052310.70590561
90Inositol phosphate metabolism_Homo sapiens_hsa005620.70443034
91Endocytosis_Homo sapiens_hsa041440.70279945
92Steroid biosynthesis_Homo sapiens_hsa001000.69917397
93Legionellosis_Homo sapiens_hsa051340.69900961
94Propanoate metabolism_Homo sapiens_hsa006400.69468989
95Prostate cancer_Homo sapiens_hsa052150.69394065
96Malaria_Homo sapiens_hsa051440.68802688
97Galactose metabolism_Homo sapiens_hsa000520.67893917
98Pentose phosphate pathway_Homo sapiens_hsa000300.67837649
99Glycerolipid metabolism_Homo sapiens_hsa005610.67833622
100Toxoplasmosis_Homo sapiens_hsa051450.67378130
101Acute myeloid leukemia_Homo sapiens_hsa052210.66452017
102Type I diabetes mellitus_Homo sapiens_hsa049400.66395828
103Vitamin digestion and absorption_Homo sapiens_hsa049770.65903062
104Viral carcinogenesis_Homo sapiens_hsa052030.65756631
105Focal adhesion_Homo sapiens_hsa045100.65056409
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64781097
107Pertussis_Homo sapiens_hsa051330.64661397
108Shigellosis_Homo sapiens_hsa051310.64373132
109Apoptosis_Homo sapiens_hsa042100.63299111
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62976907
111HIF-1 signaling pathway_Homo sapiens_hsa040660.62408741
112Thyroid cancer_Homo sapiens_hsa052160.61360788
113Biosynthesis of amino acids_Homo sapiens_hsa012300.61181287
114FoxO signaling pathway_Homo sapiens_hsa040680.59718589
115ErbB signaling pathway_Homo sapiens_hsa040120.59088498
116Tyrosine metabolism_Homo sapiens_hsa003500.58831404
117Estrogen signaling pathway_Homo sapiens_hsa049150.58050022
118Colorectal cancer_Homo sapiens_hsa052100.57504002
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.56821439
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55996132
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55958670
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55565944
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55479622
124TNF signaling pathway_Homo sapiens_hsa046680.55094020
125Proteoglycans in cancer_Homo sapiens_hsa052050.54981535
126African trypanosomiasis_Homo sapiens_hsa051430.53493392
127Antigen processing and presentation_Homo sapiens_hsa046120.52885218
128Amoebiasis_Homo sapiens_hsa051460.52697951
129Pancreatic cancer_Homo sapiens_hsa052120.52573925
130Carbon metabolism_Homo sapiens_hsa012000.52065387
131Measles_Homo sapiens_hsa051620.50679138
132Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50639998
133mTOR signaling pathway_Homo sapiens_hsa041500.49384710
134Non-small cell lung cancer_Homo sapiens_hsa052230.47233400
135Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45294888
136Influenza A_Homo sapiens_hsa051640.43496898
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.41410095
138Hepatitis C_Homo sapiens_hsa051600.40721551
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40227300
140Type II diabetes mellitus_Homo sapiens_hsa049300.40080043
141Small cell lung cancer_Homo sapiens_hsa052220.39230355
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38129758
143AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37296633
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.37247710
145Chemokine signaling pathway_Homo sapiens_hsa040620.36400905
146AMPK signaling pathway_Homo sapiens_hsa041520.35426171
147Arginine and proline metabolism_Homo sapiens_hsa003300.34889480
148NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34856610
149RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33988081
150Hematopoietic cell lineage_Homo sapiens_hsa046400.33725946
151Insulin signaling pathway_Homo sapiens_hsa049100.33192000
152Jak-STAT signaling pathway_Homo sapiens_hsa046300.32122953
153Hepatitis B_Homo sapiens_hsa051610.31557716

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