WDR73

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is thought to contain multiple WD40 repeats. WD40 repeats are motifs that contain 40-60 amino acids, and usually end with Trp-Asp (WD). This protein is found in the cytoplasm during interphase, but accumulates at the spindle poles and astral microtubules during mitosis. Reduced expression of this gene results in abnormalities in the size and morphology of the nucleus. Mutations in this gene have been associated with Galloway-Mowat syndrome PMID: 25466283), which is a rare autosomal recessive disorder that affects both the central nervous system and kidneys. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)8.84970235
2response to pheromone (GO:0019236)7.17051811
3behavioral response to nicotine (GO:0035095)5.34026571
4DNA deamination (GO:0045006)4.97940103
5maturation of SSU-rRNA (GO:0030490)4.94997265
6ribosomal small subunit assembly (GO:0000028)4.81653200
7negative regulation of macroautophagy (GO:0016242)4.63702092
8post-embryonic morphogenesis (GO:0009886)4.58582120
9purine nucleobase biosynthetic process (GO:0009113)4.42540217
10nucleobase biosynthetic process (GO:0046112)4.41532203
11epithelial cilium movement (GO:0003351)4.18346034
12negative regulation of meiosis (GO:0045835)4.16008903
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.11469988
14ribosome assembly (GO:0042255)4.03768630
15viral transcription (GO:0019083)3.95772843
16preassembly of GPI anchor in ER membrane (GO:0016254)3.94823771
17ribosomal large subunit biogenesis (GO:0042273)3.92288086
18ribosome biogenesis (GO:0042254)3.91927041
19axoneme assembly (GO:0035082)3.90404622
20translational termination (GO:0006415)3.90059555
21detection of molecule of bacterial origin (GO:0032490)3.88909521
22DNA replication initiation (GO:0006270)3.87920976
23respiratory chain complex IV assembly (GO:0008535)3.87520741
24ribonucleoprotein complex biogenesis (GO:0022613)3.81197846
25tRNA methylation (GO:0030488)3.75797319
26cilium movement (GO:0003341)3.72066078
27DNA strand elongation involved in DNA replication (GO:0006271)3.71453635
28L-fucose catabolic process (GO:0042355)3.69413704
29fucose catabolic process (GO:0019317)3.69413704
30L-fucose metabolic process (GO:0042354)3.69413704
31ribosomal small subunit biogenesis (GO:0042274)3.68489225
32regulation of cilium movement (GO:0003352)3.62607532
33translational elongation (GO:0006414)3.61811154
34telomere maintenance via semi-conservative replication (GO:0032201)3.60196061
35proteasome assembly (GO:0043248)3.59353238
36water-soluble vitamin biosynthetic process (GO:0042364)3.55362493
37spliceosomal snRNP assembly (GO:0000387)3.54697045
38DNA replication checkpoint (GO:0000076)3.54213308
39DNA strand elongation (GO:0022616)3.54160436
40formation of translation preinitiation complex (GO:0001731)3.48477167
41rRNA processing (GO:0006364)3.47141586
42energy homeostasis (GO:0097009)3.46201712
43translational initiation (GO:0006413)3.45168275
44cilium morphogenesis (GO:0060271)3.44893857
45mitochondrial respiratory chain complex I assembly (GO:0032981)3.44559864
46NADH dehydrogenase complex assembly (GO:0010257)3.44559864
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.44559864
48mitotic metaphase plate congression (GO:0007080)3.43533153
49pseudouridine synthesis (GO:0001522)3.43273681
50DNA catabolic process, exonucleolytic (GO:0000738)3.42909760
51cellular ketone body metabolic process (GO:0046950)3.41868943
52protein complex biogenesis (GO:0070271)3.41346309
53cilium or flagellum-dependent cell motility (GO:0001539)3.40470196
54positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.39368926
55nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.39097548
56rRNA metabolic process (GO:0016072)3.37131713
57nonmotile primary cilium assembly (GO:0035058)3.36978965
58cytochrome complex assembly (GO:0017004)3.36579997
59folic acid metabolic process (GO:0046655)3.33897648
60CENP-A containing nucleosome assembly (GO:0034080)3.32776769
61mitochondrial respiratory chain complex assembly (GO:0033108)3.32353800
62IMP biosynthetic process (GO:0006188)3.30803764
63neural tube formation (GO:0001841)3.30708190
64protein polyglutamylation (GO:0018095)3.23958258
65cilium organization (GO:0044782)3.21937630
66regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.21215059
67chromatin remodeling at centromere (GO:0031055)3.21020863
68auditory receptor cell stereocilium organization (GO:0060088)3.20280433
69SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.19716555
70peptidyl-histidine modification (GO:0018202)3.18908896
71base-excision repair, AP site formation (GO:0006285)3.16848294
72lateral ventricle development (GO:0021670)3.14169664
73kynurenine metabolic process (GO:0070189)3.13909564
74intraciliary transport (GO:0042073)3.13036510
75cilium assembly (GO:0042384)3.12500548
76telomere maintenance via recombination (GO:0000722)3.11178350
77cotranslational protein targeting to membrane (GO:0006613)3.09906646
78folic acid-containing compound biosynthetic process (GO:0009396)3.09527452
79transcription elongation from RNA polymerase III promoter (GO:0006385)3.07828030
80termination of RNA polymerase III transcription (GO:0006386)3.07828030
81ubiquinone biosynthetic process (GO:0006744)3.07721779
82protein targeting to ER (GO:0045047)3.07413490
83rRNA modification (GO:0000154)3.06719099
84negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.04750908
85mannosylation (GO:0097502)3.04412724
86termination of RNA polymerase I transcription (GO:0006363)3.03347451
87anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.02892680
88ketone body metabolic process (GO:1902224)3.02838287
89axonemal dynein complex assembly (GO:0070286)3.02591541
90cellular protein complex disassembly (GO:0043624)3.02186840
91regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.01773795
92cellular component biogenesis (GO:0044085)3.01727057
93ubiquinone metabolic process (GO:0006743)3.01004201
94telomere maintenance via telomere lengthening (GO:0010833)2.99849755
95replication fork processing (GO:0031297)2.99843248
96protein localization to cilium (GO:0061512)2.99648919
97indolalkylamine metabolic process (GO:0006586)2.96643252
98GPI anchor metabolic process (GO:0006505)2.96432185
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.95186487
100protein-cofactor linkage (GO:0018065)2.95042888
101viral life cycle (GO:0019058)2.94932302
102L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.94701525
103motile cilium assembly (GO:0044458)2.94524031
104DNA replication-independent nucleosome assembly (GO:0006336)2.92193381
105DNA replication-independent nucleosome organization (GO:0034724)2.92193381
106positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.91825727
107protein localization to endoplasmic reticulum (GO:0070972)2.91443351
108deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.91421819
109reciprocal DNA recombination (GO:0035825)2.91210138
110reciprocal meiotic recombination (GO:0007131)2.91210138
111somite development (GO:0061053)2.90859049
112establishment of protein localization to endoplasmic reticulum (GO:0072599)2.90152699
113peptidyl-arginine omega-N-methylation (GO:0035247)2.89946095
114DNA unwinding involved in DNA replication (GO:0006268)2.89426383
115transcription elongation from RNA polymerase I promoter (GO:0006362)2.88512733
116detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.87484347
117C-terminal protein lipidation (GO:0006501)2.87416215
118tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.86849216
119RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.86849216
120platelet dense granule organization (GO:0060155)2.86685733
121behavioral response to ethanol (GO:0048149)2.85813091
122indole-containing compound catabolic process (GO:0042436)2.85463600
123indolalkylamine catabolic process (GO:0046218)2.85463600
124tryptophan catabolic process (GO:0006569)2.85463600
125metaphase plate congression (GO:0051310)2.84496355
126mitotic recombination (GO:0006312)2.83287003
127spliceosomal complex assembly (GO:0000245)2.82809066
128mitotic nuclear envelope disassembly (GO:0007077)2.82800949
129translation (GO:0006412)2.82242019
130regulation of mitochondrial translation (GO:0070129)2.81904199
131ncRNA processing (GO:0034470)2.80766674
132histone H2A acetylation (GO:0043968)2.80287527
133IMP metabolic process (GO:0046040)2.79050824
134mitochondrial RNA metabolic process (GO:0000959)2.77650653
135C-terminal protein amino acid modification (GO:0018410)2.77165298
136ncRNA metabolic process (GO:0034660)2.77095499
137transcription from RNA polymerase I promoter (GO:0006360)2.77075956
138rRNA catabolic process (GO:0016075)2.76222142
139tRNA processing (GO:0008033)2.76017625
140spinal cord motor neuron differentiation (GO:0021522)2.75365399
141cellular anion homeostasis (GO:0030002)2.74980185
142protein complex disassembly (GO:0043241)2.74263653
143tRNA modification (GO:0006400)2.73721597
144nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.72881602
145cornea development in camera-type eye (GO:0061303)2.72676306
146regulation of centrosome cycle (GO:0046605)2.71231950
147negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.70441598
148negative regulation of ligase activity (GO:0051352)2.70441598
149histone exchange (GO:0043486)2.69265457
150pyrimidine nucleobase catabolic process (GO:0006208)2.68714594
151negative regulation of transcription regulatory region DNA binding (GO:2000678)2.67664225
152transcription-coupled nucleotide-excision repair (GO:0006283)2.67292951
153nuclear-transcribed mRNA catabolic process (GO:0000956)2.67083549
154GPI anchor biosynthetic process (GO:0006506)2.67065353
1557-methylguanosine mRNA capping (GO:0006370)2.66544171
156negative regulation of telomere maintenance (GO:0032205)2.66369195
157positive regulation of oligodendrocyte differentiation (GO:0048714)2.65034650
158maturation of 5.8S rRNA (GO:0000460)2.65025113
159protein localization to kinetochore (GO:0034501)2.64348771
160macromolecular complex disassembly (GO:0032984)2.63428443
161histone mRNA metabolic process (GO:0008334)2.63294549
162histone arginine methylation (GO:0034969)2.62514433
163synaptic transmission, cholinergic (GO:0007271)2.61080803
164recombinational repair (GO:0000725)2.55097223
165L-methionine salvage (GO:0071267)2.54416782
166L-methionine biosynthetic process (GO:0071265)2.54416782
167amino acid salvage (GO:0043102)2.54416782
168pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.53692326
169rRNA methylation (GO:0031167)2.53394563
170regulation of nuclear cell cycle DNA replication (GO:0033262)2.53026834
171GTP biosynthetic process (GO:0006183)2.52858165
172double-strand break repair via homologous recombination (GO:0000724)2.52522092
173regulation of microtubule-based movement (GO:0060632)2.51927165
174detection of light stimulus involved in visual perception (GO:0050908)2.51503205
175detection of light stimulus involved in sensory perception (GO:0050962)2.51503205
176photoreceptor cell maintenance (GO:0045494)2.49671160
177piRNA metabolic process (GO:0034587)2.49274184
178amine catabolic process (GO:0009310)2.47277269
179cellular biogenic amine catabolic process (GO:0042402)2.47277269
180regulation of action potential (GO:0098900)2.45829217
181meiotic chromosome segregation (GO:0045132)2.45802957
182tryptophan metabolic process (GO:0006568)2.43098571
183regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.42083940
184somatic hypermutation of immunoglobulin genes (GO:0016446)2.41148382
185somatic diversification of immune receptors via somatic mutation (GO:0002566)2.41148382
186regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.40347996
187regulation of mitotic spindle checkpoint (GO:1903504)2.40347996
188photoreceptor cell development (GO:0042461)2.39260991
189left/right axis specification (GO:0070986)2.38954548
190doxorubicin metabolic process (GO:0044598)13.6551076
191daunorubicin metabolic process (GO:0044597)13.6551076
192polyketide metabolic process (GO:0030638)13.6551076

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.31961493
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.98520391
3ZNF274_21170338_ChIP-Seq_K562_Hela4.57470808
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.77652470
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.53603760
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.49944116
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.43633152
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.41423842
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.40829262
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.40182553
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.39871528
12MYC_19079543_ChIP-ChIP_MESCs_Mouse3.33732820
13E2F4_17652178_ChIP-ChIP_JURKAT_Human3.26031104
14MYC_18358816_ChIP-ChIP_MESCs_Mouse3.25211984
15MYC_19030024_ChIP-ChIP_MESCs_Mouse3.07387571
16VDR_22108803_ChIP-Seq_LS180_Human2.89044995
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.88798525
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.86306430
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.83260131
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.80547883
21* VDR_23849224_ChIP-Seq_CD4+_Human2.60720172
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.60088065
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.51002514
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.45750434
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.38712103
26XRN2_22483619_ChIP-Seq_HELA_Human2.36999095
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.36303583
28EWS_26573619_Chip-Seq_HEK293_Human2.34627887
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28076480
30FOXP3_21729870_ChIP-Seq_TREG_Human2.26984256
31NOTCH1_21737748_ChIP-Seq_TLL_Human2.23272248
32GBX2_23144817_ChIP-Seq_PC3_Human2.22930836
33SALL1_21062744_ChIP-ChIP_HESCs_Human2.21176479
34ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18095312
35YY1_21170310_ChIP-Seq_MESCs_Mouse2.16827052
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13211539
37FUS_26573619_Chip-Seq_HEK293_Human2.13048079
38IGF1R_20145208_ChIP-Seq_DFB_Human2.12177799
39E2F1_18555785_ChIP-Seq_MESCs_Mouse2.10771308
40NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09382541
41* GABP_19822575_ChIP-Seq_HepG2_Human2.09197599
42TTF2_22483619_ChIP-Seq_HELA_Human1.99802150
43* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99048509
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93738978
45DCP1A_22483619_ChIP-Seq_HELA_Human1.93043746
46TAF15_26573619_Chip-Seq_HEK293_Human1.91220197
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90933326
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88926764
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85908068
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.84243016
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84159116
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.83359531
53EZH2_22144423_ChIP-Seq_EOC_Human1.79653467
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79119684
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78343033
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74895204
57TP53_22573176_ChIP-Seq_HFKS_Human1.74838230
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.74383131
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74380632
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.73394100
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72305856
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71945232
63ER_23166858_ChIP-Seq_MCF-7_Human1.71193864
64* SRF_21415370_ChIP-Seq_HL-1_Mouse1.67149120
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66051046
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.64367974
67P300_19829295_ChIP-Seq_ESCs_Human1.63529544
68AR_21909140_ChIP-Seq_LNCAP_Human1.62010332
69CIITA_25753668_ChIP-Seq_RAJI_Human1.61107033
70MYC_22102868_ChIP-Seq_BL_Human1.61073006
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53767314
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52251594
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.50191083
74PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47770399
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46441344
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.46112378
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45602870
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44190936
79HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43584958
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43053756
81KDM5A_27292631_Chip-Seq_BREAST_Human1.39115228
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38247769
83CBP_20019798_ChIP-Seq_JUKART_Human1.38167300
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38167300
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36550929
86KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35869361
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32093449
88MYC_18940864_ChIP-ChIP_HL60_Human1.31263051
89BCAT_22108803_ChIP-Seq_LS180_Human1.28560340
90ELK1_19687146_ChIP-ChIP_HELA_Human1.27372918
91ETV2_25802403_ChIP-Seq_MESCs_Mouse1.27187501
92TP63_19390658_ChIP-ChIP_HaCaT_Human1.26229767
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22740380
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22267208
95SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.22012406
96GATA3_21878914_ChIP-Seq_MCF-7_Human1.21745085
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21320567
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21016606
99FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20591813
100FOXA1_25329375_ChIP-Seq_VCAP_Human1.20591813
101CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20308317
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18852362
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18852362
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18759974
105SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18305662
106STAT3_23295773_ChIP-Seq_U87_Human1.18047815
107HOXB7_26014856_ChIP-Seq_BT474_Human1.16364542
108PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15485773
109* NCOR_22424771_ChIP-Seq_293T_Human1.15460627
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15349271
111AR_20517297_ChIP-Seq_VCAP_Human1.14985374
112RNF2_27304074_Chip-Seq_NSC_Mouse1.14042099
113NANOG_19829295_ChIP-Seq_ESCs_Human1.13890993
114SOX2_19829295_ChIP-Seq_ESCs_Human1.13890993
115PIAS1_25552417_ChIP-Seq_VCAP_Human1.13450106
116CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12954365
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12937801
118AR_25329375_ChIP-Seq_VCAP_Human1.12690403
119ERA_21632823_ChIP-Seq_H3396_Human1.12436879
120REST_21632747_ChIP-Seq_MESCs_Mouse1.10944682
121RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09472926
122NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07134761
123MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07094153
124POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05349284
125TCF4_23295773_ChIP-Seq_U87_Human1.05283020
126KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04710030
127PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03374447
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01795311
129TCF4_22108803_ChIP-Seq_LS180_Human1.01503169
130SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00839960
131NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.00775994
132RUNX2_22187159_ChIP-Seq_PCA_Human1.00409192
133SMAD4_21799915_ChIP-Seq_A2780_Human1.00180085
134AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99562995
135ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97773396
136CTCF_18555785_ChIP-Seq_MESCs_Mouse0.97361578
137AR_21572438_ChIP-Seq_LNCaP_Human0.97166248
138CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97084721
139PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96952970
140SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95595566
141CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95458414
142SMAD3_21741376_ChIP-Seq_EPCs_Human0.94412850
143SCL_19346495_ChIP-Seq_HPC-7_Human0.94256767
144CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93262219
145FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93017184
146CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92723897
147* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92449542
148ELK1_22589737_ChIP-Seq_MCF10A_Human0.92349816
149NFE2_27457419_Chip-Seq_LIVER_Mouse0.92285806
150SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91450988
151MYC_19829295_ChIP-Seq_ESCs_Human0.90710793
152SPI1_23547873_ChIP-Seq_NB4_Human0.90674459
153TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90466973
154CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90374673
155RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88179082
156VDR_21846776_ChIP-Seq_THP-1_Human0.87758640
157CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86597466
158E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.83937550
159KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83727565
160STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83379551
161CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80746366
162SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.77862473
163IRF1_19129219_ChIP-ChIP_H3396_Human0.77622993
164* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.77620571
165EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.77207245
166SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.76358658
167KAP1_27257070_Chip-Seq_ESCs_Mouse0.71582121
168CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.70919952
169POU5F1_16153702_ChIP-ChIP_HESCs_Human0.69643876
170NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.69491624
171CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.69447018
172DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.69392395
173NANOG_16153702_ChIP-ChIP_HESCs_Human0.67726324

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot6.00486629
2MP0003878_abnormal_ear_physiology6.00486629
3MP0003693_abnormal_embryo_hatching4.67100101
4MP0008004_abnormal_stomach_pH4.62910177
5MP0003111_abnormal_nucleus_morphology3.72032088
6MP0010094_abnormal_chromosome_stability3.67481333
7MP0004957_abnormal_blastocyst_morpholog3.48592512
8MP0006292_abnormal_olfactory_placode3.39311062
9MP0003077_abnormal_cell_cycle3.23610381
10MP0003136_yellow_coat_color2.92984030
11MP0009697_abnormal_copulation2.83062311
12MP0008058_abnormal_DNA_repair2.79864389
13MP0003879_abnormal_hair_cell2.73995766
14MP0002396_abnormal_hematopoietic_system2.67331499
15MP0000678_abnormal_parathyroid_gland2.57275761
16MP0006072_abnormal_retinal_apoptosis2.38686436
17MP0002653_abnormal_ependyma_morphology2.38330581
18MP0002132_abnormal_respiratory_system2.31510781
19MP0005646_abnormal_pituitary_gland2.29399482
20MP0005551_abnormal_eye_electrophysiolog2.27627210
21MP0008057_abnormal_DNA_replication2.27615930
22MP0001968_abnormal_touch/_nociception2.20969294
23MP0001485_abnormal_pinna_reflex2.12912174
24MP0002736_abnormal_nociception_after2.08610016
25MP0004142_abnormal_muscle_tone2.02008196
26MP0005645_abnormal_hypothalamus_physiol1.99409327
27MP0005253_abnormal_eye_physiology1.98179265
28MP0008875_abnormal_xenobiotic_pharmacok1.89750841
29MP0003718_maternal_effect1.85784973
30MP0008007_abnormal_cellular_replicative1.84338436
31MP0003941_abnormal_skin_development1.78058365
32MP0001293_anophthalmia1.76463462
33MP0003123_paternal_imprinting1.73965525
34MP0004043_abnormal_pH_regulation1.73526466
35MP0008789_abnormal_olfactory_epithelium1.72997109
36MP0000383_abnormal_hair_follicle1.72993686
37MP0001986_abnormal_taste_sensitivity1.72553849
38MP0003195_calcinosis1.65117564
39MP0003786_premature_aging1.62070305
40MP0001984_abnormal_olfaction1.58198516
41MP0008932_abnormal_embryonic_tissue1.57669801
42MP0000631_abnormal_neuroendocrine_gland1.57484171
43MP0002938_white_spotting1.57208464
44MP0000372_irregular_coat_pigmentation1.56003655
45MP0005423_abnormal_somatic_nervous1.52123331
46MP0003011_delayed_dark_adaptation1.51722367
47MP0003880_abnormal_central_pattern1.51343767
48MP0003787_abnormal_imprinting1.51182591
49MP0000569_abnormal_digit_pigmentation1.50923259
50MP0002102_abnormal_ear_morphology1.48161364
51MP0000427_abnormal_hair_cycle1.42885082
52MP0005084_abnormal_gallbladder_morpholo1.40537002
53MP0002735_abnormal_chemical_nociception1.36072532
54MP0009046_muscle_twitch1.35984269
55MP0002837_dystrophic_cardiac_calcinosis1.33746891
56MP0000350_abnormal_cell_proliferation1.32815509
57MP0000490_abnormal_crypts_of1.31989012
58MP0003646_muscle_fatigue1.28999795
59MP0009745_abnormal_behavioral_response1.28451249
60MP0002928_abnormal_bile_duct1.26691075
61MP0005389_reproductive_system_phenotype1.26459920
62MP0005394_taste/olfaction_phenotype1.23270033
63MP0005499_abnormal_olfactory_system1.23270033
64MP0004885_abnormal_endolymph1.22519260
65MP0002210_abnormal_sex_determination1.18358488
66MP0005075_abnormal_melanosome_morpholog1.17823050
67MP0002557_abnormal_social/conspecific_i1.15351202
68MP0000778_abnormal_nervous_system1.15207282
69MP0005195_abnormal_posterior_eye1.13879654
70MP0002876_abnormal_thyroid_physiology1.12966378
71MP0001730_embryonic_growth_arrest1.12560171
72MP0001545_abnormal_hematopoietic_system1.11829727
73MP0005397_hematopoietic_system_phenotyp1.11829727
74MP0002234_abnormal_pharynx_morphology1.11656002
75MP0006276_abnormal_autonomic_nervous1.10843985
76MP0000049_abnormal_middle_ear1.10381012
77MP0000313_abnormal_cell_death1.09777274
78MP0008877_abnormal_DNA_methylation1.09160526
79MP0005391_vision/eye_phenotype1.08910822
80MP0000647_abnormal_sebaceous_gland1.08318675
81MP0001919_abnormal_reproductive_system1.08016145
82MP0003763_abnormal_thymus_physiology1.06801571
83MP0002909_abnormal_adrenal_gland1.06645034
84MP0000538_abnormal_urinary_bladder1.06119975
85MP0001502_abnormal_circadian_rhythm1.06116526
86MP0002572_abnormal_emotion/affect_behav1.05707433
87MP0003937_abnormal_limbs/digits/tail_de1.03391719
88MP0004742_abnormal_vestibular_system1.01668059
89MP0001970_abnormal_pain_threshold1.01481613
90MP0002272_abnormal_nervous_system1.01451566
91MP0002160_abnormal_reproductive_system1.01271838
92MP0003938_abnormal_ear_development0.99504372
93MP0003121_genomic_imprinting0.99378547
94MP0005380_embryogenesis_phenotype0.99103783
95MP0001672_abnormal_embryogenesis/_devel0.99103783
96MP0000026_abnormal_inner_ear0.98546111
97MP0002752_abnormal_somatic_nervous0.97705300
98MP0004808_abnormal_hematopoietic_stem0.96998170
99MP0005187_abnormal_penis_morphology0.96758584
100MP0000703_abnormal_thymus_morphology0.96712792
101MP0010386_abnormal_urinary_bladder0.95577553
102MP0005367_renal/urinary_system_phenotyp0.94559510
103MP0000516_abnormal_urinary_system0.94559510
104MP0001486_abnormal_startle_reflex0.94244317
105MP0003122_maternal_imprinting0.93697654
106MP0000681_abnormal_thyroid_gland0.93517353
107MP0002095_abnormal_skin_pigmentation0.91090324
108MP0002080_prenatal_lethality0.90924592
109MP0002067_abnormal_sensory_capabilities0.89021317
110MP0003283_abnormal_digestive_organ0.88903981
111MP0002085_abnormal_embryonic_tissue0.88776719
112MP0004147_increased_porphyrin_level0.88126989
113MP0001764_abnormal_homeostasis0.88110012
114MP0000653_abnormal_sex_gland0.87919464
115MP0001119_abnormal_female_reproductive0.87896505
116MP0009333_abnormal_splenocyte_physiolog0.87824193
117MP0008961_abnormal_basal_metabolism0.87679315
118MP0001905_abnormal_dopamine_level0.86206036
119MP0002822_catalepsy0.86182649
120MP0001145_abnormal_male_reproductive0.86147683
121MP0002019_abnormal_tumor_incidence0.84573224
122MP0001188_hyperpigmentation0.83582376
123MP0002398_abnormal_bone_marrow0.82777640
124MP0002733_abnormal_thermal_nociception0.81904546
125MP0005171_absent_coat_pigmentation0.81562659
126MP0002163_abnormal_gland_morphology0.81317258
127MP0003315_abnormal_perineum_morphology0.80857138
128MP0001697_abnormal_embryo_size0.79690929
129MP0002722_abnormal_immune_system0.77896395
130MP0001929_abnormal_gametogenesis0.75582732
131MP0000566_synostosis0.74474709
132MP0003984_embryonic_growth_retardation0.73709108
133MP0002088_abnormal_embryonic_growth/wei0.70953268
134MP0002638_abnormal_pupillary_reflex0.70362920
135MP0005671_abnormal_response_to0.70211250
136MP0002277_abnormal_respiratory_mucosa0.70125727
137MP0002429_abnormal_blood_cell0.66080343
138MP0000689_abnormal_spleen_morphology0.65283469
139MP0009379_abnormal_foot_pigmentation0.65047393
140MP0004133_heterotaxia0.63396820
141MP0003567_abnormal_fetal_cardiomyocyte0.63270200
142MP0003806_abnormal_nucleotide_metabolis0.62575178
143MP0002086_abnormal_extraembryonic_tissu0.62541596
144MP0001529_abnormal_vocalization0.61686524
145MP0002075_abnormal_coat/hair_pigmentati0.61658147
146MP0000358_abnormal_cell_content/0.61502510
147MP0003936_abnormal_reproductive_system0.61228954
148MP0002084_abnormal_developmental_patter0.61037442
149MP0003698_abnormal_male_reproductive0.60978472
150MP0008995_early_reproductive_senescence0.58170207
151MP0003890_abnormal_embryonic-extraembry0.57968993
152MP0005174_abnormal_tail_pigmentation0.57500724
153MP0002249_abnormal_larynx_morphology0.56902440
154MP0005379_endocrine/exocrine_gland_phen0.55755412
155MP0006036_abnormal_mitochondrial_physio0.55710070
156MP0002751_abnormal_autonomic_nervous0.53306102
157MP0000716_abnormal_immune_system0.52938821
158MP0003699_abnormal_female_reproductive0.52420861
159MP0001664_abnormal_digestion0.52263844
160MP0000470_abnormal_stomach_morphology0.52230669
161MP0003119_abnormal_digestive_system0.51264699
162MP0002161_abnormal_fertility/fecundity0.48047359
163MP0001324_abnormal_eye_pigmentation0.47675645
164MP0008872_abnormal_physiological_respon0.46816908

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)6.26688082
2Unilateral renal agenesis (HP:0000122)6.24542328
3Alopecia of scalp (HP:0002293)5.53246142
4Abnormality of dental color (HP:0011073)5.01574940
5Chronic otitis media (HP:0000389)4.74525379
6Bilateral sensorineural hearing impairment (HP:0008619)4.62298898
7Absent eyelashes (HP:0000561)4.59452644
8Reticulocytopenia (HP:0001896)4.45907853
9Molar tooth sign on MRI (HP:0002419)4.43402935
10Abnormality of midbrain morphology (HP:0002418)4.43402935
11True hermaphroditism (HP:0010459)4.30010184
12Cheilitis (HP:0100825)4.24549769
13Follicular hyperkeratosis (HP:0007502)4.13859793
14Nephronophthisis (HP:0000090)4.05969273
15Absent eyebrow (HP:0002223)4.00286628
16Congenital stationary night blindness (HP:0007642)3.76051295
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.67460854
18Absent/shortened dynein arms (HP:0200106)3.67460854
19Abnormality of cells of the erythroid lineage (HP:0012130)3.66558539
20Birth length less than 3rd percentile (HP:0003561)3.63394736
21Abnormal number of erythroid precursors (HP:0012131)3.56222223
22Abnormality of the renal medulla (HP:0100957)3.49807636
23Aplastic anemia (HP:0001915)3.46748131
24Recurrent corneal erosions (HP:0000495)3.33078038
25Medial flaring of the eyebrow (HP:0010747)3.21028092
26Chronic hepatic failure (HP:0100626)3.14378468
27Erythroderma (HP:0001019)3.05691005
28Oral leukoplakia (HP:0002745)3.00191636
29Sparse eyelashes (HP:0000653)2.97766404
30Type II lissencephaly (HP:0007260)2.96711001
31Cystic liver disease (HP:0006706)2.85669215
32Patellar aplasia (HP:0006443)2.85183904
33Abnormality of the renal cortex (HP:0011035)2.84553205
343-Methylglutaconic aciduria (HP:0003535)2.81390588
35Hypoplasia of the capital femoral epiphysis (HP:0003090)2.81011461
36Abolished electroretinogram (ERG) (HP:0000550)2.80454871
37Abnormal respiratory motile cilium morphology (HP:0005938)2.78417008
38Abnormal respiratory epithelium morphology (HP:0012253)2.78417008
39Gait imbalance (HP:0002141)2.75848666
40Aplasia/Hypoplasia of the patella (HP:0006498)2.75177283
41Attenuation of retinal blood vessels (HP:0007843)2.74430153
42Chromsome breakage (HP:0040012)2.74348094
43Type 2 muscle fiber atrophy (HP:0003554)2.73621945
44Blepharitis (HP:0000498)2.72461205
45Muscle fiber atrophy (HP:0100295)2.71461573
46Chromosomal breakage induced by crosslinking agents (HP:0003221)2.70193047
47Congenital primary aphakia (HP:0007707)2.69363095
48Macrocytic anemia (HP:0001972)2.69352095
49Pallor (HP:0000980)2.67873927
50Breast hypoplasia (HP:0003187)2.66810214
51Abnormality of the preputium (HP:0100587)2.65945395
52Chronic sinusitis (HP:0011109)2.63292793
53Absent hair (HP:0002298)2.62826516
54Microretrognathia (HP:0000308)2.60072500
55Horseshoe kidney (HP:0000085)2.59963313
56Premature graying of hair (HP:0002216)2.55891748
57Sclerocornea (HP:0000647)2.55688414
58Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.54957578
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.54142864
60Abnormality of alanine metabolism (HP:0010916)2.54142864
61Hyperglycinemia (HP:0002154)2.53069961
62Increased hepatocellular lipid droplets (HP:0006565)2.53002543
63Pancytopenia (HP:0001876)2.50483526
64Absent thumb (HP:0009777)2.49072171
65Aplasia/Hypoplasia of the tongue (HP:0010295)2.48901666
66Anencephaly (HP:0002323)2.48628211
67Nephrogenic diabetes insipidus (HP:0009806)2.48553683
68Tubular atrophy (HP:0000092)2.48443189
69Abnormality of the renal collecting system (HP:0004742)2.47690783
70Rough bone trabeculation (HP:0100670)2.47211113
71Abnormality of the pons (HP:0007361)2.44778795
72Large for gestational age (HP:0001520)2.41641733
73Abnormal biliary tract physiology (HP:0012439)2.41575789
74Bile duct proliferation (HP:0001408)2.41575789
75Pendular nystagmus (HP:0012043)2.41475009
76Abnormal respiratory motile cilium physiology (HP:0012261)2.41402448
77Cerebellar dysplasia (HP:0007033)2.40671072
78Meckel diverticulum (HP:0002245)2.37390963
79Congenital hepatic fibrosis (HP:0002612)2.37066713
80Renal dysplasia (HP:0000110)2.36342625
81Cerebral hypomyelination (HP:0006808)2.34537069
82Postaxial foot polydactyly (HP:0001830)2.33475529
83Duplicated collecting system (HP:0000081)2.33085944
84Pancreatic fibrosis (HP:0100732)2.33038014
85Colon cancer (HP:0003003)2.32540703
86Mitochondrial inheritance (HP:0001427)2.32002058
87Increased CSF lactate (HP:0002490)2.30401727
88Erythema (HP:0010783)2.29897751
89Occipital encephalocele (HP:0002085)2.28481137
90Acute necrotizing encephalopathy (HP:0006965)2.27030123
91Hyperphosphatemia (HP:0002905)2.26132516
92Abnormal rod and cone electroretinograms (HP:0008323)2.22836407
93Ectropion (HP:0000656)2.22292652
94Lissencephaly (HP:0001339)2.21954249
95Absent radius (HP:0003974)2.20653054
96Abnormality of the ileum (HP:0001549)2.20420151
97Aplasia/Hypoplasia of the tibia (HP:0005772)2.18226988
98Hyperventilation (HP:0002883)2.17194885
99Lipid accumulation in hepatocytes (HP:0006561)2.14545578
100Rhinitis (HP:0012384)2.12974355
101Abnormal ciliary motility (HP:0012262)2.12721909
102Microvesicular hepatic steatosis (HP:0001414)2.11442983
103Male pseudohermaphroditism (HP:0000037)2.10682265
104Hypoplasia of the pons (HP:0012110)2.09125254
105Hepatocellular necrosis (HP:0001404)2.09015376
106Furrowed tongue (HP:0000221)2.08941438
107Absent forearm bone (HP:0003953)2.08519006
108Aplasia involving forearm bones (HP:0009822)2.08519006
109Abnormal drinking behavior (HP:0030082)2.08215159
110Polydipsia (HP:0001959)2.08215159
111Genital tract atresia (HP:0001827)2.07726682
112Acute encephalopathy (HP:0006846)2.06392661
113Abnormality of chromosome stability (HP:0003220)2.06214875
114Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04070031
115Triphalangeal thumb (HP:0001199)2.04053923
116Vaginal atresia (HP:0000148)2.03437307
117Tetany (HP:0001281)2.02990711
118Cellular immunodeficiency (HP:0005374)2.02074092
119Abnormality of pyrimidine metabolism (HP:0004353)2.01653160
120Rib fusion (HP:0000902)2.01105576
121Preaxial hand polydactyly (HP:0001177)2.01017333
122Carpal bone hypoplasia (HP:0001498)2.00580661
123Poor coordination (HP:0002370)1.99298897
124Absent epiphyses (HP:0010577)1.98374305
125Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.98374305
126Cleft eyelid (HP:0000625)1.98321819
127Aplasia/Hypoplasia of the uvula (HP:0010293)1.97548329
128Postaxial hand polydactyly (HP:0001162)1.96573859
129Abnormal mitochondria in muscle tissue (HP:0008316)1.96349794
130Bone marrow hypocellularity (HP:0005528)1.96059942
131Increased serum lactate (HP:0002151)1.95619702
132Ectopic kidney (HP:0000086)1.95385416
133Renal agenesis (HP:0000104)1.95023298
134Concave nail (HP:0001598)1.93752557
135Abnormality of DNA repair (HP:0003254)1.92095772
136Myelodysplasia (HP:0002863)1.92027633
137Retinal dysplasia (HP:0007973)1.90818649
138Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88730853
139Optic nerve coloboma (HP:0000588)1.88620442
140Supernumerary spleens (HP:0009799)1.88175448
141Lymphopenia (HP:0001888)1.88106813
142Optic disc pallor (HP:0000543)1.87026077
143Pancreatic cysts (HP:0001737)1.87015711
144Bony spicule pigmentary retinopathy (HP:0007737)1.86572950
145Abnormality of cells of the lymphoid lineage (HP:0012140)1.85765621
146Megaloblastic anemia (HP:0001889)1.85592621
147Hypergonadotropic hypogonadism (HP:0000815)1.84609757
148Medulloblastoma (HP:0002885)1.84090626
149Renal cortical cysts (HP:0000803)1.83357202
150Hepatic necrosis (HP:0002605)1.82858488
151Keratitis (HP:0000491)1.81996063
152Decreased central vision (HP:0007663)1.81846383
153Oligohydramnios (HP:0001562)1.80946328
154Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.80619610
155Decreased activity of mitochondrial respiratory chain (HP:0008972)1.80619610
156Selective tooth agenesis (HP:0001592)1.80598055
157Respiratory difficulties (HP:0002880)1.79963723
158Progressive macrocephaly (HP:0004481)1.79823570
159Neoplasm of the respiratory system (HP:0100606)1.79694019
160Anophthalmia (HP:0000528)1.78362214
161Exertional dyspnea (HP:0002875)1.78164935
162Hyperalaninemia (HP:0003348)1.77660483
163Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77489624
164Severe muscular hypotonia (HP:0006829)1.77462807
165Polyuria (HP:0000103)1.77224953
166Aganglionic megacolon (HP:0002251)1.76620948
167Absent rod-and cone-mediated responses on ERG (HP:0007688)1.76561907
168Oculomotor apraxia (HP:0000657)1.75623734
169Pachygyria (HP:0001302)1.73867475
170Chorioretinal atrophy (HP:0000533)1.72903019
171Short tibia (HP:0005736)1.72835523
172Inability to walk (HP:0002540)1.70551384
173Bilateral microphthalmos (HP:0007633)1.69943033
174Retinitis pigmentosa (HP:0000510)1.67518586
175Astigmatism (HP:0000483)1.67161855
176Tachypnea (HP:0002789)1.66025708
177Oligodactyly (hands) (HP:0001180)1.66021499

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK35.69535012
2BUB14.55627436
3WEE14.14628154
4SIK23.87932098
5FRK3.84635618
6BMPR1B3.63094439
7EPHA23.38819165
8STK162.90994208
9EIF2AK12.80894720
10MAPK152.80251520
11SRPK12.77546086
12WNK32.74589994
13SIK12.65895494
14MAP4K22.55942199
15NUAK12.45220313
16CDC72.21326586
17PAK42.20579147
18WNK42.20358332
19NME22.12843357
20GRK12.11808721
21MARK32.03343503
22ACVR1B2.01884718
23NEK22.00316951
24CDK81.86325247
25TAOK31.83779589
26MAP3K41.82704105
27MAP3K121.81341827
28TSSK61.81139911
29PLK41.80484869
30TRIM281.78925661
31INSRR1.78298383
32VRK11.75468238
33BRSK21.62934027
34NME11.53268251
35DYRK21.51909360
36CDK71.51189232
37TTK1.39877564
38DYRK31.36315718
39VRK21.32817255
40PLK11.31287160
41MARK11.30891576
42RPS6KB21.28309277
43OXSR11.28192301
44PINK11.27497517
45CASK1.26898006
46EIF2AK31.25102439
47TLK11.23545174
48CHEK21.22783863
49PAK31.22028875
50ATR1.20290257
51TGFBR11.19665734
52BRSK11.19462808
53ADRBK21.19126427
54MKNK11.13863878
55PLK31.11972537
56MUSK1.09907057
57ADRBK11.09486061
58CCNB11.09203704
59CAMKK21.04197779
60STK391.02537191
61RPS6KA41.01641400
62CDK40.99283111
63TNIK0.96894180
64KDR0.95062726
65DAPK20.94057975
66AURKB0.93343142
67RPS6KA50.91806055
68MKNK20.91309297
69EEF2K0.90860424
70PRKCE0.90524238
71NEK10.89388238
72MAP3K110.85919413
73BRAF0.84417803
74ERBB30.84340901
75PRKCG0.81595237
76LATS10.81236112
77AURKA0.80704736
78SCYL20.80267832
79LATS20.80163232
80EPHA30.79268364
81CHEK10.78011140
82BCR0.74061965
83PASK0.73680136
84PIM20.71999894
85MAP4K10.71677317
86STK38L0.71501607
87PIK3CA0.68058482
88CSNK2A20.67198158
89ZAK0.67009285
90CAMK10.63851108
91DAPK10.63843953
92CSNK1G30.63840293
93NTRK20.63567732
94TXK0.62960668
95BCKDK0.60655522
96CSNK2A10.59999031
97MAP2K40.58433130
98MAP2K20.58125263
99TAOK20.56559661
100PNCK0.55987494
101CDK190.54472778
102ALK0.53808944
103PKN10.52557940
104MAPKAPK30.52103121
105MARK20.51856949
106MAP2K60.51609277
107TIE10.51009374
108PHKG10.50341940
109PHKG20.50341940
110KIT0.50198202
111TESK20.48704222
112FLT30.46805691
113NTRK30.45980166
114CDK20.45212023
115MAP3K80.45111652
116CDK30.44615416
117CSNK1A10.43482079
118PRKAA10.43340042
119PRKCQ0.42558878
120ZAP700.40594439
121PLK20.40141530
122CSNK1A1L0.40126422
123TEC0.39908326
124MAP3K50.39679045
125MAP2K70.39613254
126MAPKAPK50.39367560
127IRAK10.38436768
128ATM0.38363459
129PIM10.37879752
130CSNK1G10.36801040
131MAPK110.36766858
132PTK2B0.36556168
133CAMK1D0.36034115
134PRKACA0.35186028
135STK110.35118137
136CHUK0.34757052
137AKT30.34374215
138EPHB20.32954500
139EPHA40.32194093
140IKBKB0.31465812
141CSNK1D0.29093606
142RPS6KA60.28889385
143PRKD20.28421857
144EIF2AK20.28210632
145STK100.25521373
146RAF10.25157399
147SYK0.25062953
148LYN0.24138332
149GRK60.24115855
150BTK0.22846232
151CSNK1G20.22809291
152MAPK130.22498132
153PRKCI0.22119465
154PAK10.21456713
155MAP2K30.21362210
156MELK0.21020353
157CDK10.20072986
158CSF1R0.20016335

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.90009033
2Ribosome_Homo sapiens_hsa030104.34955607
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.91392327
4RNA polymerase_Homo sapiens_hsa030203.83099690
5Mismatch repair_Homo sapiens_hsa034303.80477918
6Proteasome_Homo sapiens_hsa030503.74704748
7Spliceosome_Homo sapiens_hsa030403.55404768
8Homologous recombination_Homo sapiens_hsa034403.07461304
9RNA transport_Homo sapiens_hsa030132.97644030
10Pyrimidine metabolism_Homo sapiens_hsa002402.84429046
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.82238716
12Base excision repair_Homo sapiens_hsa034102.80813046
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.66541985
14Nucleotide excision repair_Homo sapiens_hsa034202.64689434
15One carbon pool by folate_Homo sapiens_hsa006702.49338587
16Cell cycle_Homo sapiens_hsa041102.34212116
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.28627254
18Butanoate metabolism_Homo sapiens_hsa006502.15931307
19Nitrogen metabolism_Homo sapiens_hsa009102.11758164
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.11321646
21Fanconi anemia pathway_Homo sapiens_hsa034602.09733244
22Phototransduction_Homo sapiens_hsa047442.07345780
23Linoleic acid metabolism_Homo sapiens_hsa005911.98425509
24Basal transcription factors_Homo sapiens_hsa030221.88245599
25RNA degradation_Homo sapiens_hsa030181.85185915
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.83011120
27Folate biosynthesis_Homo sapiens_hsa007901.76478896
28Vitamin B6 metabolism_Homo sapiens_hsa007501.72830161
29Purine metabolism_Homo sapiens_hsa002301.69951178
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60460714
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54332583
32Sulfur relay system_Homo sapiens_hsa041221.53204688
33Non-homologous end-joining_Homo sapiens_hsa034501.52400853
34Ether lipid metabolism_Homo sapiens_hsa005651.45329403
35Propanoate metabolism_Homo sapiens_hsa006401.44012047
36Peroxisome_Homo sapiens_hsa041461.42364246
37Primary immunodeficiency_Homo sapiens_hsa053401.38474945
38Tryptophan metabolism_Homo sapiens_hsa003801.36605224
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36229494
40mRNA surveillance pathway_Homo sapiens_hsa030151.26037629
41p53 signaling pathway_Homo sapiens_hsa041151.22825202
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.20345066
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20088713
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.19052836
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.17310947
46Taste transduction_Homo sapiens_hsa047421.15848126
47Alzheimers disease_Homo sapiens_hsa050101.15272272
48Caffeine metabolism_Homo sapiens_hsa002321.12234721
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09361456
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.03380941
51Pentose phosphate pathway_Homo sapiens_hsa000301.01807213
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98467778
53Steroid biosynthesis_Homo sapiens_hsa001000.98213696
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96655135
55Epstein-Barr virus infection_Homo sapiens_hsa051690.93190780
56Olfactory transduction_Homo sapiens_hsa047400.91048402
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.89240909
58Cardiac muscle contraction_Homo sapiens_hsa042600.87279656
59beta-Alanine metabolism_Homo sapiens_hsa004100.87151073
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86520425
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82433142
62ABC transporters_Homo sapiens_hsa020100.81432713
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81211318
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79475428
65Oocyte meiosis_Homo sapiens_hsa041140.77244675
66Protein export_Homo sapiens_hsa030600.76732048
67Hedgehog signaling pathway_Homo sapiens_hsa043400.74687453
68Collecting duct acid secretion_Homo sapiens_hsa049660.74622159
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71631479
70Biosynthesis of amino acids_Homo sapiens_hsa012300.71096058
71Huntingtons disease_Homo sapiens_hsa050160.69731011
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69522761
73Morphine addiction_Homo sapiens_hsa050320.68544275
74Herpes simplex infection_Homo sapiens_hsa051680.67340165
75Arachidonic acid metabolism_Homo sapiens_hsa005900.64764912
76Selenocompound metabolism_Homo sapiens_hsa004500.64380947
77Systemic lupus erythematosus_Homo sapiens_hsa053220.62661297
78Basal cell carcinoma_Homo sapiens_hsa052170.62253776
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61394975
80Retinol metabolism_Homo sapiens_hsa008300.59237210
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58597021
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58540168
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57761430
84Glycerolipid metabolism_Homo sapiens_hsa005610.57714185
85HTLV-I infection_Homo sapiens_hsa051660.57283532
86Histidine metabolism_Homo sapiens_hsa003400.54836595
87Fatty acid metabolism_Homo sapiens_hsa012120.54103089
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53466745
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52001962
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50298174
91Vitamin digestion and absorption_Homo sapiens_hsa049770.47357697
92Antigen processing and presentation_Homo sapiens_hsa046120.46823514
93Fat digestion and absorption_Homo sapiens_hsa049750.46167580
94Ovarian steroidogenesis_Homo sapiens_hsa049130.46029957
95Regulation of autophagy_Homo sapiens_hsa041400.44861014
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44326923
97Circadian entrainment_Homo sapiens_hsa047130.43852952
98Fatty acid degradation_Homo sapiens_hsa000710.43770135
99Nicotine addiction_Homo sapiens_hsa050330.43289157
100Fructose and mannose metabolism_Homo sapiens_hsa000510.42669777
101Serotonergic synapse_Homo sapiens_hsa047260.42613469
102GABAergic synapse_Homo sapiens_hsa047270.42167399
103Glutamatergic synapse_Homo sapiens_hsa047240.41850495
104Sulfur metabolism_Homo sapiens_hsa009200.41776116
105Metabolic pathways_Homo sapiens_hsa011000.41166511
106Insulin secretion_Homo sapiens_hsa049110.40605753
107Parkinsons disease_Homo sapiens_hsa050120.39634908
108Cocaine addiction_Homo sapiens_hsa050300.38902945
109Hematopoietic cell lineage_Homo sapiens_hsa046400.38074081
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34415347
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32508770
112Thyroid cancer_Homo sapiens_hsa052160.32470104
113Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31594695
114N-Glycan biosynthesis_Homo sapiens_hsa005100.31513879
115Mineral absorption_Homo sapiens_hsa049780.30826690
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.29507461
117Notch signaling pathway_Homo sapiens_hsa043300.29214223
118Axon guidance_Homo sapiens_hsa043600.28947757
119Viral carcinogenesis_Homo sapiens_hsa052030.26939013
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.26688956
121Carbon metabolism_Homo sapiens_hsa012000.25707277
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25452519
123Glutathione metabolism_Homo sapiens_hsa004800.25377068
124Oxidative phosphorylation_Homo sapiens_hsa001900.24745409
125Galactose metabolism_Homo sapiens_hsa000520.24645519
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24374864
127Intestinal immune network for IgA production_Homo sapiens_hsa046720.23703706
1282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21235323
129RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21171667
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.18897970
131Measles_Homo sapiens_hsa051620.17218054
132Shigellosis_Homo sapiens_hsa051310.17139159
133Alcoholism_Homo sapiens_hsa050340.16094238
134NF-kappa B signaling pathway_Homo sapiens_hsa040640.15581566
135Arginine and proline metabolism_Homo sapiens_hsa003300.15030480
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.14615740
137Apoptosis_Homo sapiens_hsa042100.11233745
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.10362403
139Wnt signaling pathway_Homo sapiens_hsa043100.09312774
140Hepatitis B_Homo sapiens_hsa051610.09279240
141Calcium signaling pathway_Homo sapiens_hsa040200.09066167
142Toll-like receptor signaling pathway_Homo sapiens_hsa046200.08574741
143Circadian rhythm_Homo sapiens_hsa047100.08020698
144Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.05442407
145MicroRNAs in cancer_Homo sapiens_hsa052060.05358478
146Chemical carcinogenesis_Homo sapiens_hsa052040.05075287
147Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.04982322
148T cell receptor signaling pathway_Homo sapiens_hsa046600.04354493
149HIF-1 signaling pathway_Homo sapiens_hsa040660.02847174
150FoxO signaling pathway_Homo sapiens_hsa040680.00172750
151Pentose and glucuronate interconversions_Homo sapiens_hsa00040-0.0210941
152Lysine degradation_Homo sapiens_hsa00310-0.0167804
153Melanoma_Homo sapiens_hsa05218-0.0007346

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