WDR47

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.73333312
2pyrimidine nucleobase catabolic process (GO:0006208)5.66636922
3synaptic vesicle exocytosis (GO:0016079)5.24337156
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.15581032
5vocalization behavior (GO:0071625)5.14325192
6neuron cell-cell adhesion (GO:0007158)5.05894420
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.05535662
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.02141844
9protein localization to synapse (GO:0035418)4.99099795
10synaptic vesicle maturation (GO:0016188)4.97727332
11glutamate secretion (GO:0014047)4.96469431
12regulation of synaptic vesicle exocytosis (GO:2000300)4.90839748
13locomotory exploration behavior (GO:0035641)4.69375593
14regulation of glutamate receptor signaling pathway (GO:1900449)4.60157552
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.54344932
16nucleobase catabolic process (GO:0046113)4.54270666
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.50568700
18regulation of synaptic vesicle transport (GO:1902803)4.40496915
19establishment of mitochondrion localization (GO:0051654)4.36544591
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.28559578
21glutamate receptor signaling pathway (GO:0007215)4.25661805
22neurotransmitter-gated ion channel clustering (GO:0072578)4.12911480
23synaptic transmission, glutamatergic (GO:0035249)4.11841738
24neurotransmitter secretion (GO:0007269)4.08979291
25exploration behavior (GO:0035640)4.07761678
26layer formation in cerebral cortex (GO:0021819)4.06465301
27neuron-neuron synaptic transmission (GO:0007270)4.03512558
28neuron recognition (GO:0008038)4.02821767
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.95954979
30neuronal action potential propagation (GO:0019227)3.93901945
31regulation of neuronal synaptic plasticity (GO:0048168)3.93775830
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.77190003
33positive regulation of synapse maturation (GO:0090129)3.74593929
34presynaptic membrane assembly (GO:0097105)3.72507777
35regulation of synapse structural plasticity (GO:0051823)3.71613399
36axonal fasciculation (GO:0007413)3.70816655
37negative regulation of synaptic transmission, GABAergic (GO:0032229)3.68628447
38gamma-aminobutyric acid signaling pathway (GO:0007214)3.67722365
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.64903398
40dendritic spine morphogenesis (GO:0060997)3.63454561
41postsynaptic membrane organization (GO:0001941)3.63188866
42synaptic vesicle endocytosis (GO:0048488)3.55904335
43regulation of postsynaptic membrane potential (GO:0060078)3.55606014
44presynaptic membrane organization (GO:0097090)3.53275324
45long-term synaptic potentiation (GO:0060291)3.49997245
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.48701544
47neurotransmitter transport (GO:0006836)3.47913652
48G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.47431479
49positive regulation of membrane potential (GO:0045838)3.47236879
50long-term memory (GO:0007616)3.47146094
51regulation of neurotransmitter secretion (GO:0046928)3.47096846
52cellular potassium ion homeostasis (GO:0030007)3.46015256
53gamma-aminobutyric acid transport (GO:0015812)3.44433588
54regulation of vesicle fusion (GO:0031338)3.43637554
55transmission of nerve impulse (GO:0019226)3.43300485
56regulation of dendritic spine morphogenesis (GO:0061001)3.37910614
57proline transport (GO:0015824)3.37079378
58regulation of synaptic plasticity (GO:0048167)3.35734774
59regulation of synaptic transmission, glutamatergic (GO:0051966)3.33099168
60neuronal ion channel clustering (GO:0045161)3.30192491
61response to histamine (GO:0034776)3.27784469
62positive regulation of neurotransmitter secretion (GO:0001956)3.25970022
63positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.25597997
64cerebellar Purkinje cell differentiation (GO:0021702)3.25277305
65mitochondrion transport along microtubule (GO:0047497)3.24314005
66establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.24314005
67dendrite morphogenesis (GO:0048813)3.23665994
68neuromuscular synaptic transmission (GO:0007274)3.22719286
69regulation of neurotransmitter transport (GO:0051588)3.20300619
70positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.19046533
71positive regulation of neurotransmitter transport (GO:0051590)3.18874567
72synapse assembly (GO:0007416)3.17461037
73auditory behavior (GO:0031223)3.16107709
74behavioral fear response (GO:0001662)3.15732047
75behavioral defense response (GO:0002209)3.15732047
76positive regulation of dendritic spine development (GO:0060999)3.15644256
77cell migration in hindbrain (GO:0021535)3.15312910
78behavioral response to cocaine (GO:0048148)3.13790668
79innervation (GO:0060384)3.13425628
80regulation of synapse maturation (GO:0090128)3.10153772
81regulation of neurotransmitter levels (GO:0001505)3.09331003
82response to auditory stimulus (GO:0010996)3.07743708
83central nervous system neuron axonogenesis (GO:0021955)3.07157166
84positive regulation of synaptic transmission, GABAergic (GO:0032230)3.05997836
85mechanosensory behavior (GO:0007638)3.04857610
86fear response (GO:0042596)3.04477001
87membrane depolarization (GO:0051899)3.03408098
88learning (GO:0007612)3.02572011
89adult walking behavior (GO:0007628)3.02376705
90regulation of voltage-gated calcium channel activity (GO:1901385)3.00438646
91membrane hyperpolarization (GO:0060081)2.98131871
92G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.97960181
93cerebellar granule cell differentiation (GO:0021707)2.97845949
94startle response (GO:0001964)2.97539944
95activation of protein kinase A activity (GO:0034199)2.97055195
96organelle transport along microtubule (GO:0072384)2.95840150
97regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.95590673
98positive regulation of dendritic spine morphogenesis (GO:0061003)2.95207448
99regulation of dendritic spine development (GO:0060998)2.94913947
100vesicle transport along microtubule (GO:0047496)2.94873354
101membrane depolarization during action potential (GO:0086010)2.93590867
102regulation of synapse assembly (GO:0051963)2.93113222
103negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.92280244
104synaptic transmission (GO:0007268)2.91447116
105acidic amino acid transport (GO:0015800)2.91205919
106positive regulation of synaptic transmission (GO:0050806)2.89672715
107sodium ion export (GO:0071436)2.88402725
108neurofilament cytoskeleton organization (GO:0060052)2.87975468
109central nervous system projection neuron axonogenesis (GO:0021952)2.87816254
110regulation of synaptic transmission (GO:0050804)2.87112070
111neuromuscular process controlling balance (GO:0050885)2.85952382
112positive regulation of synapse assembly (GO:0051965)2.84461481
113synapse organization (GO:0050808)2.84208335
114intraspecies interaction between organisms (GO:0051703)2.82837582
115social behavior (GO:0035176)2.82837582
116regulation of glutamate secretion (GO:0014048)2.82506924
117dendrite development (GO:0016358)2.82203492
118cerebral cortex radially oriented cell migration (GO:0021799)2.78601534
119establishment of synaptic vesicle localization (GO:0097480)2.76101487
120synaptic vesicle transport (GO:0048489)2.76101487
121amino acid import (GO:0043090)2.74921019
122axon extension (GO:0048675)2.72044798
123positive regulation of potassium ion transmembrane transport (GO:1901381)2.71778073

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.85281742
2GBX2_23144817_ChIP-Seq_PC3_Human3.86485632
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02435554
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97679926
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.86856012
6REST_21632747_ChIP-Seq_MESCs_Mouse2.60855250
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.53027390
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.53027390
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.50928609
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49877499
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48768040
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45193360
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35014705
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34474260
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32266158
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.25652245
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.18258882
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15375501
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.14135251
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.12993143
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12603901
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.12230772
23DROSHA_22980978_ChIP-Seq_HELA_Human2.09012139
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.06687661
25TAF15_26573619_Chip-Seq_HEK293_Human2.06374025
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05561470
27AR_21572438_ChIP-Seq_LNCaP_Human1.97856793
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.92665484
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87750788
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87494974
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86562117
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81729717
33SMAD4_21799915_ChIP-Seq_A2780_Human1.77468513
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76783160
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76551962
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69052507
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64936991
38P300_19829295_ChIP-Seq_ESCs_Human1.62837560
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62819735
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.56886585
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49384897
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47991477
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.46748886
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45558999
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.44104842
46RNF2_27304074_Chip-Seq_NSC_Mouse1.41406202
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40229833
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39612250
49IGF1R_20145208_ChIP-Seq_DFB_Human1.39125810
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37796259
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37421831
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36460954
53VDR_22108803_ChIP-Seq_LS180_Human1.36386069
54AR_25329375_ChIP-Seq_VCAP_Human1.35488653
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.35113298
56FUS_26573619_Chip-Seq_HEK293_Human1.34472401
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.33385880
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32029679
59ZNF274_21170338_ChIP-Seq_K562_Hela1.31911010
60STAT3_23295773_ChIP-Seq_U87_Human1.31244160
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29419369
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28441372
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.27753843
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26114621
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.23144307
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19992458
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17193157
68* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16505484
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.16431608
70* TCF4_23295773_ChIP-Seq_U87_Human1.15935804
71* AR_19668381_ChIP-Seq_PC3_Human1.14827870
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13974048
73RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13383265
74CBP_20019798_ChIP-Seq_JUKART_Human1.13203447
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13203447
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12718383
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.12245448
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.12042875
79RING1B_27294783_Chip-Seq_NPCs_Mouse1.11182438
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10411988
81RUNX2_22187159_ChIP-Seq_PCA_Human1.09763110
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09680969
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09119114
84MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08714692
85AHR_22903824_ChIP-Seq_MCF-7_Human1.07913649
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07333402
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06608073
88* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06574441
89ER_23166858_ChIP-Seq_MCF-7_Human1.06375038
90TAL1_26923725_Chip-Seq_HPCs_Mouse1.05925026
91SOX9_26525672_Chip-Seq_HEART_Mouse1.05516620
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05422225
93YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05328614
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.05285524
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04367295
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04314284
97JUN_21703547_ChIP-Seq_K562_Human1.03189474
98EWS_26573619_Chip-Seq_HEK293_Human1.03018662
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00729836
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00726731
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00726731
102FLI1_21867929_ChIP-Seq_TH2_Mouse1.00514732
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00427408
104WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99444406
105* SMAD3_21741376_ChIP-Seq_ESCs_Human0.97019877
106GATA1_26923725_Chip-Seq_HPCs_Mouse0.96809423
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96567570
108KDM2B_26808549_Chip-Seq_REH_Human0.96547178
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96203000
110TP53_16413492_ChIP-PET_HCT116_Human0.96188360
111BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94380824
112TP53_18474530_ChIP-ChIP_U2OS_Human0.94017642
113* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92935478
114BCAT_22108803_ChIP-Seq_LS180_Human0.92291153
115E2F1_18555785_Chip-Seq_ESCs_Mouse0.90193503
116RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90150802
117SMAD4_21741376_ChIP-Seq_HESCs_Human0.89509739

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.69842926
2MP0003880_abnormal_central_pattern5.16458472
3MP0003635_abnormal_synaptic_transmissio3.94782794
4MP0004270_analgesia3.79366241
5MP0009745_abnormal_behavioral_response3.27386074
6MP0002063_abnormal_learning/memory/cond3.23653145
7MP0001968_abnormal_touch/_nociception3.00116276
8MP0002064_seizures2.96665648
9MP0009046_muscle_twitch2.87442203
10MP0005423_abnormal_somatic_nervous2.84009656
11MP0002572_abnormal_emotion/affect_behav2.75028032
12MP0002734_abnormal_mechanical_nocicepti2.72077656
13MP0001486_abnormal_startle_reflex2.58934751
14MP0002272_abnormal_nervous_system2.50551678
15MP0002736_abnormal_nociception_after2.33580004
16MP0002735_abnormal_chemical_nociception2.25521031
17MP0002822_catalepsy2.18539735
18MP0001440_abnormal_grooming_behavior2.15423859
19MP0000778_abnormal_nervous_system2.13086369
20MP0001501_abnormal_sleep_pattern2.05046169
21MP0002733_abnormal_thermal_nociception2.02559239
22MP0002184_abnormal_innervation2.02345103
23MP0006276_abnormal_autonomic_nervous2.00356737
24MP0002067_abnormal_sensory_capabilities1.99659144
25MP0001984_abnormal_olfaction1.94375300
26MP0001970_abnormal_pain_threshold1.93594630
27MP0009780_abnormal_chondrocyte_physiolo1.85882235
28MP0002557_abnormal_social/conspecific_i1.83591332
29MP0008877_abnormal_DNA_methylation1.82814994
30MP0003329_amyloid_beta_deposits1.76275482
31MP0005551_abnormal_eye_electrophysiolog1.75612606
32MP0004924_abnormal_behavior1.75582585
33MP0005386_behavior/neurological_phenoty1.75582585
34MP0004811_abnormal_neuron_physiology1.68438719
35MP0001529_abnormal_vocalization1.65680398
36MP0001188_hyperpigmentation1.64783951
37MP0005646_abnormal_pituitary_gland1.64778772
38MP0008569_lethality_at_weaning1.61532097
39MP0003787_abnormal_imprinting1.61244539
40MP0000955_abnormal_spinal_cord1.57717061
41MP0002882_abnormal_neuron_morphology1.57221057
42MP0003879_abnormal_hair_cell1.51910657
43MP0004858_abnormal_nervous_system1.46009182
44MP0001905_abnormal_dopamine_level1.45658956
45MP0002909_abnormal_adrenal_gland1.43326821
46MP0005645_abnormal_hypothalamus_physiol1.41876202
47MP0001502_abnormal_circadian_rhythm1.40099960
48MP0004885_abnormal_endolymph1.37819324
49MP0002066_abnormal_motor_capabilities/c1.36949016
50MP0006072_abnormal_retinal_apoptosis1.24761416
51MP0010386_abnormal_urinary_bladder1.23639017
52MP0004142_abnormal_muscle_tone1.22525661
53MP0002638_abnormal_pupillary_reflex1.18112275
54MP0002152_abnormal_brain_morphology1.15548671
55MP0003122_maternal_imprinting1.15217079
56MP0002229_neurodegeneration1.13112168
57MP0003633_abnormal_nervous_system1.10775999
58MP0004742_abnormal_vestibular_system1.10030303
59MP0005499_abnormal_olfactory_system1.09899913
60MP0005394_taste/olfaction_phenotype1.09899913
61MP0002752_abnormal_somatic_nervous1.06019124
62MP0001986_abnormal_taste_sensitivity1.05246044
63MP0000631_abnormal_neuroendocrine_gland1.02249290
64MP0003631_nervous_system_phenotype1.00650862
65MP0004145_abnormal_muscle_electrophysio1.00197252
66MP0005253_abnormal_eye_physiology0.97445875
67MP0001963_abnormal_hearing_physiology0.97201175
68MP0000569_abnormal_digit_pigmentation0.91374328
69MP0005409_darkened_coat_color0.90843168
70MP0002234_abnormal_pharynx_morphology0.89853738
71MP0003690_abnormal_glial_cell0.88391331
72MP0002069_abnormal_eating/drinking_beha0.88080852
73MP0003634_abnormal_glial_cell0.84994391
74MP0000751_myopathy0.82096140
75MP0004085_abnormal_heartbeat0.81394903
76MP0008872_abnormal_physiological_respon0.80896426
77MP0002102_abnormal_ear_morphology0.80588674
78MP0002090_abnormal_vision0.80102184
79MP0001177_atelectasis0.78661468
80MP0003632_abnormal_nervous_system0.76882308
81MP0003698_abnormal_male_reproductive0.73329474
82MP0003861_abnormal_nervous_system0.72003897
83MP0002653_abnormal_ependyma_morphology0.71959287
84MP0000013_abnormal_adipose_tissue0.71762249
85MP0002837_dystrophic_cardiac_calcinosis0.71395170
86MP0006292_abnormal_olfactory_placode0.70764196
87MP0000026_abnormal_inner_ear0.69896279
88MP0005623_abnormal_meninges_morphology0.68984573
89MP0001485_abnormal_pinna_reflex0.67687143
90MP0004215_abnormal_myocardial_fiber0.65832419
91MP0005195_abnormal_posterior_eye0.65290818
92MP0008874_decreased_physiological_sensi0.65240731
93MP0003119_abnormal_digestive_system0.65066701
94MP0002876_abnormal_thyroid_physiology0.64235327
95MP0005535_abnormal_body_temperature0.63567628
96MP0001664_abnormal_digestion0.62993669
97MP0000604_amyloidosis0.62816638
98MP0005187_abnormal_penis_morphology0.61559884
99MP0008789_abnormal_olfactory_epithelium0.61491363
100MP0002160_abnormal_reproductive_system0.61378336
101MP0004233_abnormal_muscle_weight0.61333065
102MP0002081_perinatal_lethality0.60772189
103MP0010770_preweaning_lethality0.60255723
104MP0002082_postnatal_lethality0.60255723
105MP0000647_abnormal_sebaceous_gland0.59715119
106MP0010769_abnormal_survival0.58966260
107MP0000920_abnormal_myelination0.58963981
108MP0004484_altered_response_of0.58230799
109MP0010768_mortality/aging0.57249767
110MP0005248_abnormal_Harderian_gland0.55854955
111MP0003137_abnormal_impulse_conducting0.55658411
112MP0001943_abnormal_respiration0.54555704
113MP0003938_abnormal_ear_development0.54359622
114MP0002751_abnormal_autonomic_nervous0.53731124
115MP0001299_abnormal_eye_distance/0.53236323
116MP0008995_early_reproductive_senescence0.53151987
117MP0000049_abnormal_middle_ear0.52190100
118MP0003121_genomic_imprinting0.50920567

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.90277789
2Myokymia (HP:0002411)5.59627506
3Focal seizures (HP:0007359)5.24353171
4Epileptic encephalopathy (HP:0200134)5.13526391
5Febrile seizures (HP:0002373)4.62890092
6Visual hallucinations (HP:0002367)4.61020667
7Atonic seizures (HP:0010819)4.48752405
8Progressive cerebellar ataxia (HP:0002073)4.20601001
9Absence seizures (HP:0002121)3.95704606
10Dialeptic seizures (HP:0011146)3.59440304
11Generalized tonic-clonic seizures (HP:0002069)3.56226753
12Broad-based gait (HP:0002136)3.51368645
13Supranuclear gaze palsy (HP:0000605)3.39000042
14Hyperventilation (HP:0002883)3.38880477
15Action tremor (HP:0002345)3.23272081
16Ankle clonus (HP:0011448)3.15644078
17Excessive salivation (HP:0003781)3.04222289
18Drooling (HP:0002307)3.04222289
19Amblyopia (HP:0000646)3.03140859
20Mutism (HP:0002300)3.00290827
21Gaze-evoked nystagmus (HP:0000640)3.00134267
22Truncal ataxia (HP:0002078)2.91618801
23Urinary bladder sphincter dysfunction (HP:0002839)2.89976651
24Dysdiadochokinesis (HP:0002075)2.89360262
25Limb dystonia (HP:0002451)2.84213311
26Impaired vibration sensation in the lower limbs (HP:0002166)2.80192240
27Poor eye contact (HP:0000817)2.79946924
28Abnormal eating behavior (HP:0100738)2.76742481
29Gait imbalance (HP:0002141)2.75241171
30Neurofibrillary tangles (HP:0002185)2.74581137
31Genetic anticipation (HP:0003743)2.73899389
32Cerebral inclusion bodies (HP:0100314)2.71582051
33Progressive inability to walk (HP:0002505)2.70312717
34Dysmetria (HP:0001310)2.67613212
35Depression (HP:0000716)2.66504162
36Abnormality of the corticospinal tract (HP:0002492)2.63595316
37Hemiparesis (HP:0001269)2.63518079
38Congenital stationary night blindness (HP:0007642)2.62289636
39Anxiety (HP:0000739)2.60501728
40Epileptiform EEG discharges (HP:0011182)2.57840133
41Split foot (HP:0001839)2.54555933
42Insidious onset (HP:0003587)2.53926336
43Termporal pattern (HP:0011008)2.53926336
44Polyphagia (HP:0002591)2.52070317
45Shoulder girdle muscle weakness (HP:0003547)2.49651930
46Abnormality of binocular vision (HP:0011514)2.48760843
47Diplopia (HP:0000651)2.48760843
48Absent speech (HP:0001344)2.45225753
49Fetal akinesia sequence (HP:0001989)2.44211607
50Inability to walk (HP:0002540)2.43389949
51EEG with generalized epileptiform discharges (HP:0011198)2.42817731
52Impaired social interactions (HP:0000735)2.40853785
53Abnormal social behavior (HP:0012433)2.40853785
54Impaired smooth pursuit (HP:0007772)2.40164256
55Postural instability (HP:0002172)2.38174818
56Spastic gait (HP:0002064)2.37533560
57Urinary urgency (HP:0000012)2.34416811
58Retinal dysplasia (HP:0007973)2.31064879
59Cortical dysplasia (HP:0002539)2.30946918
60Morphological abnormality of the pyramidal tract (HP:0002062)2.30404077
61Stereotypic behavior (HP:0000733)2.25095777
62Central scotoma (HP:0000603)2.23015909
63Papilledema (HP:0001085)2.21359741
64Hypsarrhythmia (HP:0002521)2.20107292
65Bradykinesia (HP:0002067)2.19731147
66Congenital primary aphakia (HP:0007707)2.19118635
67Medial flaring of the eyebrow (HP:0010747)2.18502020
68Scanning speech (HP:0002168)2.18279516
69Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.17155044
70Status epilepticus (HP:0002133)2.17068251
71Hypoplasia of the corpus callosum (HP:0002079)2.15620230
72Lower limb muscle weakness (HP:0007340)2.14911302
73Akinesia (HP:0002304)2.14414728
74Amyotrophic lateral sclerosis (HP:0007354)2.13984505
75Spastic tetraplegia (HP:0002510)2.12919610
76Abnormality of salivation (HP:0100755)2.12825606
77Clonus (HP:0002169)2.11758712
78Lissencephaly (HP:0001339)2.10788463
79Peripheral hypomyelination (HP:0007182)2.09637033
80Abnormality of macular pigmentation (HP:0008002)2.08997691
81Pachygyria (HP:0001302)2.08120184
82Specific learning disability (HP:0001328)2.07690013
83Protruding tongue (HP:0010808)2.06929126
84Atrophy/Degeneration involving motor neurons (HP:0007373)2.06204467
85Poor coordination (HP:0002370)2.05974746
86Torticollis (HP:0000473)2.04015412
87Abnormality of the hip-girdle musculature (HP:0001445)2.03439743
88Abnormality of the musculature of the pelvis (HP:0001469)2.03439743
89Papillary thyroid carcinoma (HP:0002895)2.03042861
90Nephrogenic diabetes insipidus (HP:0009806)2.02702118
91Pheochromocytoma (HP:0002666)2.02603355
92Abnormality of ocular smooth pursuit (HP:0000617)2.02431306
93Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.01889160
94Degeneration of the lateral corticospinal tracts (HP:0002314)2.01889160
95Rimmed vacuoles (HP:0003805)2.01126314
96Hemiplegia (HP:0002301)2.00864536
97Megalencephaly (HP:0001355)2.00527581
98Ulnar claw (HP:0001178)1.99852452
99Abnormality of the lower motor neuron (HP:0002366)1.99128633
100Esotropia (HP:0000565)1.98418020
101Paraplegia (HP:0010550)1.98090320
102Hepatoblastoma (HP:0002884)1.94733508
103Focal dystonia (HP:0004373)1.94266543
104Generalized myoclonic seizures (HP:0002123)1.94180265
105Inappropriate behavior (HP:0000719)1.94175575
106Dynein arm defect of respiratory motile cilia (HP:0012255)1.93586994
107Absent/shortened dynein arms (HP:0200106)1.93586994
108Delusions (HP:0000746)1.93542101
109Thickened helices (HP:0000391)1.90732646
110Impaired vibratory sensation (HP:0002495)1.89943844
111Failure to thrive in infancy (HP:0001531)1.88104088
112Genital tract atresia (HP:0001827)1.87402401
113Exotropia (HP:0000577)1.86759998
114Spastic paraplegia (HP:0001258)1.86709021
115Agitation (HP:0000713)1.85640394
116Oligodactyly (hands) (HP:0001180)1.85582417
117Vaginal atresia (HP:0000148)1.85353972
118Aplasia/Hypoplasia of the brainstem (HP:0007362)1.84506792
119Hypoplasia of the brainstem (HP:0002365)1.84506792
120Intention tremor (HP:0002080)1.83649252
121Apathy (HP:0000741)1.83311890
122Hyperthyroidism (HP:0000836)1.82367878
123Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.78627723
124Tubulointerstitial nephritis (HP:0001970)1.78008814
125Dysmetric saccades (HP:0000641)1.77842140
126Abnormal hair whorl (HP:0010721)1.77422788
127Blue irides (HP:0000635)1.77422265
128Intellectual disability, severe (HP:0010864)1.76895440
129Incomplete penetrance (HP:0003829)1.75791729
130Abnormal ciliary motility (HP:0012262)1.75526332
131Craniofacial dystonia (HP:0012179)1.72055508

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.19072464
2EPHA44.13292838
3NTRK33.90066326
4MAP3K93.53915454
5MAP3K43.30836633
6MAP2K73.07424373
7CASK2.94040728
8MINK12.57752526
9NTRK22.13354731
10DAPK22.09419536
11PAK62.03480231
12MAP3K121.96694575
13MAP2K41.83234516
14PLK21.82301565
15PNCK1.79161913
16MAPK131.75403087
17RIPK41.74249914
18KSR11.72036373
19KSR21.68374767
20NTRK11.57301602
21MAP4K21.54299859
22TNIK1.49343013
23TRIM281.47653653
24CDK51.46832750
25GRK51.45618166
26SIK21.41325682
27DAPK11.31211414
28CAMKK11.26418369
29PRPF4B1.25033644
30PRKD31.23463704
31CSNK1A1L1.22942985
32ARAF1.18865033
33PRKCG1.18708277
34CDK191.16987837
35BMPR21.16493107
36PHKG21.13298458
37PHKG11.13298458
38CAMK2A1.07373239
39UHMK11.06279140
40LATS21.06252183
41SGK2231.00670333
42SGK4941.00670333
43DYRK1A0.97744326
44CSNK1G10.94985692
45FES0.94563636
46CDK180.92189116
47STK380.90171533
48AKT30.89639110
49MAP3K20.88513106
50MAP3K130.87993548
51CAMK2B0.87238967
52CDK150.86811636
53OXSR10.86637811
54CSNK1G20.86257708
55CDK140.84627217
56CCNB10.83771528
57SGK20.82232148
58ERBB30.80451576
59SIK30.78012730
60BCR0.77363185
61PAK30.76872738
62EPHA30.76844894
63CAMKK20.76505706
64DYRK30.75931572
65CDK11A0.74582684
66TYRO30.74551210
67RAF10.74225654
68MARK20.74155813
69DYRK20.72854032
70PRKCE0.71040148
71CAMK40.70581776
72STK110.70208142
73MAP3K50.69167270
74PTK2B0.69006584
75DYRK1B0.66466291
76NME10.66339662
77FGR0.66196536
78MAP3K60.65795141
79BRAF0.65195325
80SGK10.65099745
81CAMK10.64219809
82PINK10.61503860
83RET0.61015663
84WNK30.57327803
85LIMK10.56810563
86PRKCZ0.52915580
87FER0.51420143
88GRK70.49745480
89PKN10.49638453
90CAMK2D0.49452069
91SGK30.49247401
92RPS6KA40.48210280
93BRD40.47827636
94PRKCH0.46938138
95TAOK10.46302270
96NEK60.43650146
97CDK30.43588967
98CAMK1G0.41986772
99MAPK100.41472583
100RPS6KA30.40552407
101PRKG10.40282276
102CSNK1G30.38843755
103BCKDK0.38673472
104CAMK2G0.38602386
105ADRBK10.37596383
106ROCK20.37248982
107MAPK120.36752672
108CDC42BPA0.36652948
109MUSK0.36570399
110FYN0.36546105
111MAP2K10.36425370
112CSNK1D0.36356408
113PRKCB0.33770264
114STK390.32376705
115CSNK1E0.31001527
116EPHB20.30400800
117PRKACA0.30363610
118NEK10.30016473
119PRKACB0.29828119
120ADRBK20.28497317
121MAPK150.28350132
122MAPK90.24750302

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.90920259
2Synaptic vesicle cycle_Homo sapiens_hsa047213.39653938
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.78816807
4GABAergic synapse_Homo sapiens_hsa047272.71441801
5Olfactory transduction_Homo sapiens_hsa047402.71332675
6Circadian entrainment_Homo sapiens_hsa047132.64415514
7Long-term potentiation_Homo sapiens_hsa047202.56898166
8Glutamatergic synapse_Homo sapiens_hsa047242.55906715
9Morphine addiction_Homo sapiens_hsa050322.53808845
10Amphetamine addiction_Homo sapiens_hsa050312.42063108
11Phototransduction_Homo sapiens_hsa047442.34383876
12Dopaminergic synapse_Homo sapiens_hsa047282.25333381
13Salivary secretion_Homo sapiens_hsa049702.09091044
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.97189218
15Serotonergic synapse_Homo sapiens_hsa047261.95171471
16Insulin secretion_Homo sapiens_hsa049111.95059689
17Taste transduction_Homo sapiens_hsa047421.90652314
18Cholinergic synapse_Homo sapiens_hsa047251.89144410
19Collecting duct acid secretion_Homo sapiens_hsa049661.80914108
20Renin secretion_Homo sapiens_hsa049241.79380802
21Long-term depression_Homo sapiens_hsa047301.75538948
22Gastric acid secretion_Homo sapiens_hsa049711.71379927
23Cocaine addiction_Homo sapiens_hsa050301.67161907
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64997857
25Oxytocin signaling pathway_Homo sapiens_hsa049211.63866478
26Calcium signaling pathway_Homo sapiens_hsa040201.51803248
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51382689
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42342401
29GnRH signaling pathway_Homo sapiens_hsa049121.41133011
30Axon guidance_Homo sapiens_hsa043601.37934301
31Gap junction_Homo sapiens_hsa045401.37192090
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27187065
33cAMP signaling pathway_Homo sapiens_hsa040241.24622348
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23597663
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15598545
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11247088
37Vibrio cholerae infection_Homo sapiens_hsa051101.11049706
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09323804
39Estrogen signaling pathway_Homo sapiens_hsa049151.08346846
40ErbB signaling pathway_Homo sapiens_hsa040121.06634698
41Melanogenesis_Homo sapiens_hsa049161.03699058
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03416617
43Regulation of autophagy_Homo sapiens_hsa041401.02958065
44Glioma_Homo sapiens_hsa052141.00526573
45Type II diabetes mellitus_Homo sapiens_hsa049300.99001399
46Cardiac muscle contraction_Homo sapiens_hsa042600.97699561
47Oocyte meiosis_Homo sapiens_hsa041140.95905508
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.95117262
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91260417
50Steroid biosynthesis_Homo sapiens_hsa001000.83608791
51Dorso-ventral axis formation_Homo sapiens_hsa043200.80719292
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80550362
53Pancreatic secretion_Homo sapiens_hsa049720.77957543
54Choline metabolism in cancer_Homo sapiens_hsa052310.76227425
55MAPK signaling pathway_Homo sapiens_hsa040100.74167145
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.73747879
57Circadian rhythm_Homo sapiens_hsa047100.72505359
58Ras signaling pathway_Homo sapiens_hsa040140.69481810
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69010570
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67124074
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66536884
62Dilated cardiomyopathy_Homo sapiens_hsa054140.65517086
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64394801
64Alcoholism_Homo sapiens_hsa050340.63211155
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62686544
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60916469
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59797852
68Thyroid hormone synthesis_Homo sapiens_hsa049180.59482178
69Butanoate metabolism_Homo sapiens_hsa006500.59326890
70Wnt signaling pathway_Homo sapiens_hsa043100.58919401
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58198648
72Alzheimers disease_Homo sapiens_hsa050100.57672738
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.56982434
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56850503
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56265793
76VEGF signaling pathway_Homo sapiens_hsa043700.55719152
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.52562275
78Hippo signaling pathway_Homo sapiens_hsa043900.52315590
79Renal cell carcinoma_Homo sapiens_hsa052110.52071171
80Rap1 signaling pathway_Homo sapiens_hsa040150.50670407
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49236548
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47710504
83Inositol phosphate metabolism_Homo sapiens_hsa005620.47402410
84Type I diabetes mellitus_Homo sapiens_hsa049400.47297967
85Endometrial cancer_Homo sapiens_hsa052130.47219010
86Glucagon signaling pathway_Homo sapiens_hsa049220.46921962
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46242537
88Oxidative phosphorylation_Homo sapiens_hsa001900.45790453
89AMPK signaling pathway_Homo sapiens_hsa041520.45524242
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45388787
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44871352
92Ovarian steroidogenesis_Homo sapiens_hsa049130.44173123
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43514371
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42378935
95Fatty acid biosynthesis_Homo sapiens_hsa000610.41921387
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41441566
97Endocytosis_Homo sapiens_hsa041440.41060807
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40069446
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39685386
100Colorectal cancer_Homo sapiens_hsa052100.39662211
101Rheumatoid arthritis_Homo sapiens_hsa053230.35760791
102mTOR signaling pathway_Homo sapiens_hsa041500.35703664
103Phagosome_Homo sapiens_hsa041450.35465567
104Basal transcription factors_Homo sapiens_hsa030220.33870143
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33045496
106Insulin signaling pathway_Homo sapiens_hsa049100.31454990
107African trypanosomiasis_Homo sapiens_hsa051430.30892763
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30525037
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30482304
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29542558
111beta-Alanine metabolism_Homo sapiens_hsa004100.29485341
112Prion diseases_Homo sapiens_hsa050200.29220019
113Chemokine signaling pathway_Homo sapiens_hsa040620.29020471
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28411951
115Salmonella infection_Homo sapiens_hsa051320.28163756
116Hedgehog signaling pathway_Homo sapiens_hsa043400.27800892
117Non-small cell lung cancer_Homo sapiens_hsa052230.26236035
118Prolactin signaling pathway_Homo sapiens_hsa049170.25881473

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