WDR4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.81398040
2nucleobase biosynthetic process (GO:0046112)5.09442255
3DNA strand elongation involved in DNA replication (GO:0006271)4.99565170
4maturation of SSU-rRNA (GO:0030490)4.93960230
5DNA strand elongation (GO:0022616)4.78088649
6DNA unwinding involved in DNA replication (GO:0006268)4.74674148
7formation of translation preinitiation complex (GO:0001731)4.71097516
8purine nucleobase biosynthetic process (GO:0009113)4.64806663
9telomere maintenance via semi-conservative replication (GO:0032201)4.54359231
10DNA replication initiation (GO:0006270)4.52871200
11folic acid-containing compound biosynthetic process (GO:0009396)4.51731417
12ribosomal small subunit assembly (GO:0000028)4.48895306
13nuclear pore complex assembly (GO:0051292)4.44633645
14regulation of translational fidelity (GO:0006450)4.41104449
15ribosome biogenesis (GO:0042254)4.38660319
16IMP biosynthetic process (GO:0006188)4.25439369
17viral transcription (GO:0019083)4.13234517
18mitotic sister chromatid segregation (GO:0000070)4.12697350
19mitotic chromosome condensation (GO:0007076)4.11561594
20DNA replication checkpoint (GO:0000076)4.11519727
21ribonucleoprotein complex biogenesis (GO:0022613)4.09668772
22mitotic metaphase plate congression (GO:0007080)4.08572114
23translational termination (GO:0006415)4.08063107
24ribosome assembly (GO:0042255)4.01369263
25folic acid metabolic process (GO:0046655)4.00848297
26ribosomal large subunit biogenesis (GO:0042273)3.94863744
27pseudouridine synthesis (GO:0001522)3.91192847
28translational initiation (GO:0006413)3.90224382
29protein localization to kinetochore (GO:0034501)3.87869476
30translational elongation (GO:0006414)3.87360434
31spliceosomal snRNP assembly (GO:0000387)3.87242083
32telomere maintenance via recombination (GO:0000722)3.86014993
33mitotic nuclear envelope disassembly (GO:0007077)3.83036436
34ribosomal small subunit biogenesis (GO:0042274)3.77314924
35rRNA processing (GO:0006364)3.72240611
36negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.70504249
37sister chromatid segregation (GO:0000819)3.67478928
38regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.65820815
39nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.61121478
40deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.60895977
41IMP metabolic process (GO:0046040)3.60610673
42mitotic recombination (GO:0006312)3.60601289
43rRNA metabolic process (GO:0016072)3.59825182
44protein complex localization (GO:0031503)3.59552121
45telomere maintenance via telomere lengthening (GO:0010833)3.58707642
46nuclear envelope disassembly (GO:0051081)3.56034610
47membrane disassembly (GO:0030397)3.56034610
48proline biosynthetic process (GO:0006561)3.52587561
49cellular protein complex localization (GO:0034629)3.51792710
50DNA replication-dependent nucleosome assembly (GO:0006335)3.51699895
51DNA replication-dependent nucleosome organization (GO:0034723)3.51699895
52establishment of integrated proviral latency (GO:0075713)3.49184554
53transcription from mitochondrial promoter (GO:0006390)3.42834150
54SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.42696071
55pore complex assembly (GO:0046931)3.42623146
56metaphase plate congression (GO:0051310)3.41675299
57negative regulation of RNA splicing (GO:0033119)3.38726665
58proteasome assembly (GO:0043248)3.37738481
59mitochondrial RNA metabolic process (GO:0000959)3.34517122
60protein targeting to ER (GO:0045047)3.30965805
61cotranslational protein targeting to membrane (GO:0006613)3.30684375
62nucleobase-containing small molecule interconversion (GO:0015949)3.29032708
63DNA topological change (GO:0006265)3.25661580
64spliceosomal tri-snRNP complex assembly (GO:0000244)3.24824085
65negative regulation of mRNA metabolic process (GO:1903312)3.24179493
66peptidyl-arginine omega-N-methylation (GO:0035247)3.23487230
67negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.23363314
68nucleotide-excision repair, DNA gap filling (GO:0006297)3.21941952
69cellular protein complex disassembly (GO:0043624)3.20699435
70rRNA modification (GO:0000154)3.20060004
71anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.18427890
72protein localization to chromosome, centromeric region (GO:0071459)3.17599687
73rRNA transcription (GO:0009303)3.17136518
74transcription elongation from RNA polymerase III promoter (GO:0006385)3.16776006
75termination of RNA polymerase III transcription (GO:0006386)3.16776006
76regulation of mitochondrial translation (GO:0070129)3.16444337
77viral life cycle (GO:0019058)3.15586839
78L-serine metabolic process (GO:0006563)3.15253440
79CENP-A containing nucleosome assembly (GO:0034080)3.15182757
80spliceosomal complex assembly (GO:0000245)3.13647171
81regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.13023201
82tRNA aminoacylation for protein translation (GO:0006418)3.12944770
83establishment of protein localization to endoplasmic reticulum (GO:0072599)3.12742902
84protein localization to endoplasmic reticulum (GO:0070972)3.11764675
85nuclear pore organization (GO:0006999)3.11636831
86regulation of translational termination (GO:0006449)3.11273826
87pteridine-containing compound biosynthetic process (GO:0042559)3.10614829
88maturation of 5.8S rRNA (GO:0000460)3.09359340
89heterochromatin organization (GO:0070828)3.09067888
90positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.07772605
91cellular component biogenesis (GO:0044085)3.07745971
92amino acid activation (GO:0043038)3.07166371
93tRNA aminoacylation (GO:0043039)3.07166371
94negative regulation of mRNA processing (GO:0050686)3.07155157
95RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.06060214
96mRNA splicing, via spliceosome (GO:0000398)3.06060214
97chromatin remodeling at centromere (GO:0031055)3.05839554
98DNA duplex unwinding (GO:0032508)3.05004273
99RNA splicing, via transesterification reactions (GO:0000375)3.04581929
100protein complex disassembly (GO:0043241)3.03688853
101DNA geometric change (GO:0032392)3.02294197
102pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.00875403
103transcription-coupled nucleotide-excision repair (GO:0006283)2.99878078
104DNA replication-independent nucleosome organization (GO:0034724)2.99351915
105DNA replication-independent nucleosome assembly (GO:0006336)2.99351915
106translation (GO:0006412)2.99106854
107mitochondrial DNA metabolic process (GO:0032042)2.98259701
108termination of RNA polymerase II transcription (GO:0006369)2.98155949
109nuclear envelope organization (GO:0006998)2.97338545
110DNA conformation change (GO:0071103)2.97102744
111nuclear-transcribed mRNA catabolic process (GO:0000956)2.96588565
112histone arginine methylation (GO:0034969)2.96245728
113negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.95296269
114negative regulation of ligase activity (GO:0051352)2.95296269
115establishment of chromosome localization (GO:0051303)2.94641966
116G1/S transition of mitotic cell cycle (GO:0000082)2.93643657
117cell cycle G1/S phase transition (GO:0044843)2.93643657
118regulation of spindle organization (GO:0090224)2.93355835
119viral mRNA export from host cell nucleus (GO:0046784)2.91243244
120macromolecular complex disassembly (GO:0032984)2.89667958
121double-strand break repair via nonhomologous end joining (GO:0006303)2.89226490
122non-recombinational repair (GO:0000726)2.89226490
123peptidyl-arginine methylation (GO:0018216)2.88314112
124peptidyl-arginine N-methylation (GO:0035246)2.88314112
125* ncRNA processing (GO:0034470)2.88125306
126chromatin assembly or disassembly (GO:0006333)2.87904931
127base-excision repair (GO:0006284)2.87056867
128pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.85674027
129translesion synthesis (GO:0019985)2.84128224
130exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83277804
131tetrahydrofolate metabolic process (GO:0046653)2.83264982
132RNA catabolic process (GO:0006401)2.83069940
133negative regulation of chromosome segregation (GO:0051985)2.81966378
134rRNA methylation (GO:0031167)2.80277050
135positive regulation of chromosome segregation (GO:0051984)2.78331856
136mitotic sister chromatid cohesion (GO:0007064)2.77828241
137chromosome segregation (GO:0007059)2.72256216
138regulation of translational elongation (GO:0006448)2.71766857

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.07091331
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.43268588
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.14063584
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.27769674
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.07975888
6* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.01091380
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.98234336
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.95048783
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.93996223
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.93187718
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.85088710
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.79935369
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.74866253
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.65832043
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.59470011
16* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53136444
17XRN2_22483619_ChIP-Seq_HELA_Human2.47280722
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24208733
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17720333
20* VDR_23849224_ChIP-Seq_CD4+_Human2.07636781
21* GABP_19822575_ChIP-Seq_HepG2_Human2.07515941
22MYC_22102868_ChIP-Seq_BL_Human2.05736713
23CIITA_25753668_ChIP-Seq_RAJI_Human2.00631424
24DCP1A_22483619_ChIP-Seq_HELA_Human2.00371670
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00022774
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99146088
27FOXP3_21729870_ChIP-Seq_TREG_Human1.93518655
28THAP11_20581084_ChIP-Seq_MESCs_Mouse1.90956159
29AR_21909140_ChIP-Seq_LNCAP_Human1.88035164
30* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87917531
31* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85554646
32* TTF2_22483619_ChIP-Seq_HELA_Human1.84472077
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.77617352
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76116829
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75339875
36* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74907407
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.73966920
38ZFX_18555785_ChIP-Seq_MESCs_Mouse1.73050377
39* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67002934
40* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65308040
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65057570
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65028422
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.64403805
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.64002592
45* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63907568
46KDM5A_27292631_Chip-Seq_BREAST_Human1.55085617
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49367788
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47620729
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46087215
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43387642
51VDR_21846776_ChIP-Seq_THP-1_Human1.40350099
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.40007718
53DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.39476387
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37592238
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37519674
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33206537
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31975790
58* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31240057
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.28577824
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.27514502
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26341963
62ZNF263_19887448_ChIP-Seq_K562_Human1.23638307
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22630270
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21251334
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21023240
66* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20773642
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20303947
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.19885180
69CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19441233
70TFEB_21752829_ChIP-Seq_HELA_Human1.17647736
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13069768
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12172468
73SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12018782
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11367937
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11325475
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10689098
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10253549
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08930270
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08857418
80* ELK1_19687146_ChIP-ChIP_HELA_Human1.08733766
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08647848
82* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07812494
83* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06221647
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01666695
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99998885
86TET1_21451524_ChIP-Seq_MESCs_Mouse0.99708878
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99166439
88* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99028478
89ELK3_25401928_ChIP-Seq_HUVEC_Human0.98171624
90SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97598155
91SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97191456
92* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96386126
93RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95868692
94NCOR1_26117541_ChIP-Seq_K562_Human0.95473278
95SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.94646750
96RACK7_27058665_Chip-Seq_MCF-7_Human0.93881334
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93576304
98CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93053613
99TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91379464
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91183068
101* FOXP1_21924763_ChIP-Seq_HESCs_Human0.90097764
102CHD1_26751641_Chip-Seq_LNCaP_Human0.89658114
103SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89469760
104SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89022550
105LXR_22292898_ChIP-Seq_THP-1_Human0.88289104
106MYC_18940864_ChIP-ChIP_HL60_Human0.87768480
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87380598
108ELK1_22589737_ChIP-Seq_MCF10A_Human0.85401714
109OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84414319
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84195706
111ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83871701
112* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83047030
113SPI1_23547873_ChIP-Seq_NB4_Human0.82042096

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.90153910
2MP0004957_abnormal_blastocyst_morpholog4.72172114
3MP0003111_abnormal_nucleus_morphology4.70159827
4MP0010094_abnormal_chromosome_stability4.24419057
5MP0003077_abnormal_cell_cycle4.05488981
6MP0008057_abnormal_DNA_replication3.38029357
7MP0008058_abnormal_DNA_repair3.14982068
8MP0008007_abnormal_cellular_replicative2.87855226
9MP0002396_abnormal_hematopoietic_system2.81034550
10MP0008932_abnormal_embryonic_tissue2.70213361
11MP0001730_embryonic_growth_arrest2.59453040
12MP0003123_paternal_imprinting2.42120315
13MP0000350_abnormal_cell_proliferation2.37987325
14MP0010352_gastrointestinal_tract_polyps2.31737508
15MP0005451_abnormal_body_composition2.10034607
16MP0004233_abnormal_muscle_weight2.05008195
17MP0001697_abnormal_embryo_size1.87102106
18MP0001672_abnormal_embryogenesis/_devel1.87026071
19MP0005380_embryogenesis_phenotype1.87026071
20MP0002080_prenatal_lethality1.86780362
21MP0000490_abnormal_crypts_of1.81842482
22MP0003786_premature_aging1.77671780
23MP0001293_anophthalmia1.76545952
24MP0003984_embryonic_growth_retardation1.72099619
25MP0004808_abnormal_hematopoietic_stem1.70650312
26MP0003718_maternal_effect1.70513702
27MP0002088_abnormal_embryonic_growth/wei1.68716220
28MP0008260_abnormal_autophagy1.64771491
29MP0004185_abnormal_adipocyte_glucose1.64568448
30MP0000313_abnormal_cell_death1.64000840
31MP0003806_abnormal_nucleotide_metabolis1.59841720
32MP0005501_abnormal_skin_physiology1.57873614
33MP0002085_abnormal_embryonic_tissue1.56718077
34MP0002796_impaired_skin_barrier1.53106128
35MP0005397_hematopoietic_system_phenotyp1.51672521
36MP0001545_abnormal_hematopoietic_system1.51672521
37MP0010307_abnormal_tumor_latency1.48643270
38MP0003567_abnormal_fetal_cardiomyocyte1.47331999
39MP0002019_abnormal_tumor_incidence1.46801083
40MP0009333_abnormal_splenocyte_physiolog1.46789470
41MP0002084_abnormal_developmental_patter1.46152946
42MP0002877_abnormal_melanocyte_morpholog1.46093957
43MP0002086_abnormal_extraembryonic_tissu1.43148066
44MP0001661_extended_life_span1.42342860
45MP0000358_abnormal_cell_content/1.39794776
46MP0005076_abnormal_cell_differentiation1.38663265
47MP0010030_abnormal_orbit_morphology1.38428917
48MP0004197_abnormal_fetal_growth/weight/1.34294089
49MP0009697_abnormal_copulation1.28811607
50MP0003890_abnormal_embryonic-extraembry1.27517911
51MP0000678_abnormal_parathyroid_gland1.20927599
52MP0003941_abnormal_skin_development1.20151970
53MP0003763_abnormal_thymus_physiology1.19573699
54MP0000703_abnormal_thymus_morphology1.19271323
55MP0003119_abnormal_digestive_system1.17301521
56MP0000537_abnormal_urethra_morphology1.14005557
57MP0003705_abnormal_hypodermis_morpholog1.10572320
58MP0002398_abnormal_bone_marrow1.09265900
59MP0009053_abnormal_anal_canal1.09197661
60MP0002722_abnormal_immune_system1.07450167
61MP0000689_abnormal_spleen_morphology1.03311180
62MP0003221_abnormal_cardiomyocyte_apopto1.00861700
63MP0006035_abnormal_mitochondrial_morpho1.00501365
64MP0008877_abnormal_DNA_methylation1.00473746
65MP0009840_abnormal_foam_cell0.98321082
66MP0002132_abnormal_respiratory_system0.97427473
67MP0006036_abnormal_mitochondrial_physio0.96264434
68MP0002111_abnormal_tail_morphology0.95488751
69MP0003453_abnormal_keratinocyte_physiol0.94769085
70MP0009672_abnormal_birth_weight0.94446916
71MP0005083_abnormal_biliary_tract0.92791216
72MP0002653_abnormal_ependyma_morphology0.91356050
73MP0005384_cellular_phenotype0.91280286
74MP0001873_stomach_inflammation0.91140263
75MP0003121_genomic_imprinting0.91091366
76MP0002092_abnormal_eye_morphology0.90378577
77MP0002429_abnormal_blood_cell0.90095423
78MP0009278_abnormal_bone_marrow0.90077062
79MP0003656_abnormal_erythrocyte_physiolo0.88326563
80MP0000858_altered_metastatic_potential0.83725826
81MP0002210_abnormal_sex_determination0.83504013
82MP0001145_abnormal_male_reproductive0.82803323
83MP0003315_abnormal_perineum_morphology0.82465549
84MP0005621_abnormal_cell_physiology0.81354188
85MP0006292_abnormal_olfactory_placode0.81144486
86MP0002060_abnormal_skin_morphology0.75976619
87MP0005075_abnormal_melanosome_morpholog0.75605473
88MP0000428_abnormal_craniofacial_morphol0.75219099
89MP0001881_abnormal_mammary_gland0.75043532
90MP0000477_abnormal_intestine_morphology0.74077885
91MP0001216_abnormal_epidermal_layer0.73775938
92MP0006054_spinal_hemorrhage0.73505041
93MP0000003_abnormal_adipose_tissue0.73057355
94MP0000598_abnormal_liver_morphology0.73050572
95MP0008770_decreased_survivor_rate0.72629151
96MP0002160_abnormal_reproductive_system0.71980769
97MP0004782_abnormal_surfactant_physiolog0.71902658
98MP0001915_intracranial_hemorrhage0.70662045
99MP0009931_abnormal_skin_appearance0.70340221
100MP0008995_early_reproductive_senescence0.70207241
101MP0000716_abnormal_immune_system0.67605956
102MP0005220_abnormal_exocrine_pancreas0.67553806
103MP0001346_abnormal_lacrimal_gland0.67129562
104MP0001849_ear_inflammation0.66544364
105MP0005023_abnormal_wound_healing0.65860307
106MP0003186_abnormal_redox_activity0.65633993
107MP0004264_abnormal_extraembryonic_tissu0.64557795
108MP0009379_abnormal_foot_pigmentation0.63679992
109MP0002254_reproductive_system_inflammat0.62314126
110MP0003699_abnormal_female_reproductive0.62260693
111MP0000653_abnormal_sex_gland0.61973958
112MP0002932_abnormal_joint_morphology0.60429378
113MP0009703_decreased_birth_body0.59961150
114MP0001853_heart_inflammation0.59214021
115MP0003283_abnormal_digestive_organ0.59194846
116MP0000750_abnormal_muscle_regeneration0.58302755
117MP0001727_abnormal_embryo_implantation0.57514763
118MP0001929_abnormal_gametogenesis0.57178364
119MP0005174_abnormal_tail_pigmentation0.56660514
120MP0010234_abnormal_vibrissa_follicle0.55635169
121MP0010630_abnormal_cardiac_muscle0.55610263
122MP0003937_abnormal_limbs/digits/tail_de0.55584483
123MP0001764_abnormal_homeostasis0.54564580
124MP0002089_abnormal_postnatal_growth/wei0.54516198
125MP0000733_abnormal_muscle_development0.54048667
126MP0005330_cardiomyopathy0.53719276
127MP0002697_abnormal_eye_size0.53581284
128MP0000579_abnormal_nail_morphology0.53087602
129MP0003566_abnormal_cell_adhesion0.52885826
130MP0000371_diluted_coat_color0.52843650
131MP0002970_abnormal_white_adipose0.51410849
132MP0001119_abnormal_female_reproductive0.51142544
133MP0002938_white_spotting0.48806255

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.61612761
2Abnormal number of erythroid precursors (HP:0012131)4.53152064
3Birth length less than 3rd percentile (HP:0003561)4.46451589
4Reticulocytopenia (HP:0001896)4.45299720
5Colon cancer (HP:0003003)3.84345607
6Breast hypoplasia (HP:0003187)3.80049605
7Oral leukoplakia (HP:0002745)3.71098780
8Aplastic anemia (HP:0001915)3.64157163
9Degeneration of anterior horn cells (HP:0002398)3.58683701
10Abnormality of the anterior horn cell (HP:0006802)3.58683701
11Ragged-red muscle fibers (HP:0003200)3.52666885
12Selective tooth agenesis (HP:0001592)3.48239900
13Cerebral hypomyelination (HP:0006808)3.48189580
14Multiple enchondromatosis (HP:0005701)3.43056788
15Microretrognathia (HP:0000308)3.32454653
16Rough bone trabeculation (HP:0100670)3.31260770
17Patellar aplasia (HP:0006443)3.23725569
18Trismus (HP:0000211)3.22782122
19Macrocytic anemia (HP:0001972)3.22239165
20Ependymoma (HP:0002888)3.16999963
21Pallor (HP:0000980)3.15137363
22Aplasia/Hypoplasia of the patella (HP:0006498)3.05713387
23Carpal bone hypoplasia (HP:0001498)2.98895108
2411 pairs of ribs (HP:0000878)2.98229705
25Progressive external ophthalmoplegia (HP:0000590)2.96677912
26Progressive muscle weakness (HP:0003323)2.90514495
27Aplasia/Hypoplasia of the sacrum (HP:0008517)2.77389175
28Type I transferrin isoform profile (HP:0003642)2.71409547
29Absent thumb (HP:0009777)2.65085304
30Abnormal number of incisors (HP:0011064)2.60011085
31Abnormality of glycolysis (HP:0004366)2.59021214
32Squamous cell carcinoma (HP:0002860)2.55235710
33Testicular atrophy (HP:0000029)2.55121465
34CNS hypomyelination (HP:0003429)2.55049599
35Neoplasm of the pancreas (HP:0002894)2.54852972
36Abnormality of reticulocytes (HP:0004312)2.54492343
37Thrombocytosis (HP:0001894)2.49106965
38Megaloblastic anemia (HP:0001889)2.47849648
39Facial cleft (HP:0002006)2.46221552
40Premature ovarian failure (HP:0008209)2.44663141
41Secondary amenorrhea (HP:0000869)2.44229521
42Overlapping toe (HP:0001845)2.41002596
43Septate vagina (HP:0001153)2.39740483
44Premature graying of hair (HP:0002216)2.39504004
45Medulloblastoma (HP:0002885)2.38884995
46Abnormality of pyrimidine metabolism (HP:0004353)2.35390063
47Cholecystitis (HP:0001082)2.32972222
48Abnormal gallbladder physiology (HP:0012438)2.32972222
49Pelvic girdle muscle weakness (HP:0003749)2.31114722
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.30119212
51Cellular immunodeficiency (HP:0005374)2.29779940
52Atrophy/Degeneration involving motor neurons (HP:0007373)2.25847533
53Abnormality of the calcaneus (HP:0008364)2.25836419
54Reduced antithrombin III activity (HP:0001976)2.23753947
55Myelodysplasia (HP:0002863)2.23106655
56Rhabdomyosarcoma (HP:0002859)2.22745857
57Glossoptosis (HP:0000162)2.21732747
58Cleft eyelid (HP:0000625)2.21654123
59Increased serum pyruvate (HP:0003542)2.21533629
60Impulsivity (HP:0100710)2.20832626
61Atresia of the external auditory canal (HP:0000413)2.19487961
62Abnormal glycosylation (HP:0012345)2.18324878
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.18324878
64Abnormal protein N-linked glycosylation (HP:0012347)2.18324878
65Abnormal protein glycosylation (HP:0012346)2.18324878
66Hypergonadotropic hypogonadism (HP:0000815)2.17845475
67Missing ribs (HP:0000921)2.16101351
68Microvesicular hepatic steatosis (HP:0001414)2.13302332
69Pancytopenia (HP:0001876)2.12964975
70Abnormal trabecular bone morphology (HP:0100671)2.11990913
71Abnormality of the umbilical cord (HP:0010881)2.09795129
72Chromosomal breakage induced by crosslinking agents (HP:0003221)2.08388024
73Abnormal mitochondria in muscle tissue (HP:0008316)2.07020458
74Meckel diverticulum (HP:0002245)2.06365140
75Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.05843330
76Horseshoe kidney (HP:0000085)2.05191154
77Hypoplasia of the pons (HP:0012110)2.03342389
78Abnormal umbilical cord blood vessels (HP:0011403)2.03075684
79Single umbilical artery (HP:0001195)2.03075684
80Abnormality of the fetal cardiovascular system (HP:0010948)2.03075684
81Abnormality of the preputium (HP:0100587)2.03004985
82Truncus arteriosus (HP:0001660)2.02916069
83Hyperacusis (HP:0010780)2.02665758
84Proximal placement of thumb (HP:0009623)2.01985568
85Postnatal microcephaly (HP:0005484)1.99809441
86Homocystinuria (HP:0002156)1.99648828
87Abnormality of homocysteine metabolism (HP:0010919)1.99648828
88Chromsome breakage (HP:0040012)1.99461368
89Basal cell carcinoma (HP:0002671)1.98671808
90Increased nuchal translucency (HP:0010880)1.98247786
91Abnormality of the musculature of the pelvis (HP:0001469)1.98209910
92Abnormality of the hip-girdle musculature (HP:0001445)1.98209910
93Decreased activity of mitochondrial respiratory chain (HP:0008972)1.97452615
94Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.97452615
95Broad distal phalanx of finger (HP:0009836)1.97061986
96Abnormality of the ileum (HP:0001549)1.96965767
97Optic nerve coloboma (HP:0000588)1.96289417
98Abnormality of cochlea (HP:0000375)1.95369656
99Absent radius (HP:0003974)1.93731333
100Intestinal fistula (HP:0100819)1.93448588
101Abnormality of the astrocytes (HP:0100707)1.91716698
102Astrocytoma (HP:0009592)1.91716698
103Shoulder girdle muscle weakness (HP:0003547)1.91595506
104Poor head control (HP:0002421)1.91195709
105Personality changes (HP:0000751)1.90894532
106Sparse lateral eyebrow (HP:0005338)1.89234349
107Slender long bone (HP:0003100)1.89076750
108Urethral obstruction (HP:0000796)1.88271226
109Acute encephalopathy (HP:0006846)1.87627459
110Increased intramyocellular lipid droplets (HP:0012240)1.85449614
111Ectopic kidney (HP:0000086)1.84970587
112Duplicated collecting system (HP:0000081)1.84674617
113Tracheoesophageal fistula (HP:0002575)1.84577787
114Glioma (HP:0009733)1.84486507
115Nonimmune hydrops fetalis (HP:0001790)1.83997575
116Bone marrow hypocellularity (HP:0005528)1.83611658
117Ureteral duplication (HP:0000073)1.83298332
118Exercise intolerance (HP:0003546)1.83181949
119Abnormality of the carotid arteries (HP:0005344)1.83039497
120Vaginal fistula (HP:0004320)1.82679144
121Short thumb (HP:0009778)1.82433582
122Choanal atresia (HP:0000453)1.82225085
123Respiratory difficulties (HP:0002880)1.82119758
124Deviation of the thumb (HP:0009603)1.81740593
125Spastic diplegia (HP:0001264)1.80749598
126Small intestinal stenosis (HP:0012848)1.80263060
127Duodenal stenosis (HP:0100867)1.80263060
128Increased CSF lactate (HP:0002490)1.78599686
129Prominent nose (HP:0000448)1.78239427
130Increased serum lactate (HP:0002151)1.77820973
131Absent forearm bone (HP:0003953)1.77790443
132Aplasia involving forearm bones (HP:0009822)1.77790443
133Hyperglycinemia (HP:0002154)1.77776261
134Aplasia/Hypoplasia of the uvula (HP:0010293)1.77607866
135Nephroblastoma (Wilms tumor) (HP:0002667)1.77168688
136Prominent metopic ridge (HP:0005487)1.76403745
137Calcaneovalgus deformity (HP:0001848)1.76269931
138Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75500917
139Poikiloderma (HP:0001029)1.75134184
140Short middle phalanx of the 5th finger (HP:0004220)1.74318410
141Neoplasm of striated muscle (HP:0009728)1.74093579
142Cafe-au-lait spot (HP:0000957)1.73034543
143Agnosia (HP:0010524)1.72672995
144Impaired proprioception (HP:0010831)1.72176741
145Abnormality of the heme biosynthetic pathway (HP:0010472)1.72047454
146Sloping forehead (HP:0000340)1.71688730
147Sparse eyelashes (HP:0000653)1.71661064
148Abnormality of chromosome stability (HP:0003220)1.71654605
149Angiofibromas (HP:0010615)1.71545664
150Adenoma sebaceum (HP:0009720)1.71545664
151Rectovaginal fistula (HP:0000143)1.71533142
152Rectal fistula (HP:0100590)1.71533142
153Entropion (HP:0000621)1.71421213
154Acute necrotizing encephalopathy (HP:0006965)1.70871523

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.09824313
2WEE13.88742064
3SMG13.61349020
4CDC73.52570508
5EIF2AK12.94894016
6VRK22.91650711
7NME22.89198650
8NEK22.68238287
9STK162.48558718
10IRAK32.38147182
11TLK12.21824266
12TSSK62.16804247
13ICK2.11460919
14TESK22.10008893
15NEK12.05906632
16VRK12.02541460
17EEF2K2.00805518
18SRPK11.94341451
19PBK1.89020078
20CDK71.82779488
21RPS6KA41.80506627
22PKN21.80271644
23EIF2AK31.73594409
24PLK11.70996086
25TTK1.69530757
26PASK1.68207985
27SCYL21.66701658
28DYRK31.63050655
29ATR1.62299595
30BRSK21.62082552
31TRIB31.61961064
32ACVR1B1.60623207
33MAP4K11.47432616
34MAP3K101.46201557
35EPHA21.42948521
36AURKB1.40161123
37PAK41.36597773
38MAP3K81.36424895
39BRSK11.35318079
40PDK21.35301045
41RPS6KB21.32854473
42CCNB11.31880864
43MAP3K111.27661221
44TGFBR11.26677122
45MKNK11.25464833
46PLK31.24799940
47AURKA1.24166734
48PLK41.22559524
49CHEK21.15836894
50PIM21.15696200
51CDK41.15218118
52PRPF4B1.02968461
53TAF11.02540030
54BCKDK1.01572856
55FLT30.99918061
56CHEK10.98867518
57KDR0.95344622
58TESK10.95336557
59LRRK20.93333008
60CDK120.93141389
61STK100.92908786
62ERN10.91868529
63MAP2K30.90203461
64TAOK20.90055883
65ALK0.89460093
66MAP3K30.87265883
67MST1R0.84841787
68CDK20.78855086
69ARAF0.74834832
70BLK0.74480537
71CLK10.73365354
72MKNK20.72703445
73CDK90.71224342
74PAK10.70895495
75CSNK2A20.69891613
76MELK0.67781207
77ZAP700.66151951
78PRKCI0.63787486
79BRD40.63719676
80MTOR0.63680093
81ATM0.63437602
82LATS20.59939940
83CDK80.59110666
84CSNK2A10.58973224
85BRAF0.58639308
86PIM10.58428582
87SIK10.58327933
88GRK60.57140243
89TTN0.55351059
90AKT20.54716528
91IRAK20.53799567
92BTK0.52394630
93CDK10.47577444
94NME10.47570574
95ILK0.42925961
96DAPK10.42139749
97PAK20.40520375
98BMX0.40413783
99ZAK0.39579744
100FGFR40.38164906
101CSNK1E0.38053563
102MAPK110.37603097
103RPS6KA50.36592278
104CDK60.36373282
105MAPKAPK30.36246624
106CAMK1D0.36013820
107MAP2K20.35912097
108MST40.33262908
109TAOK10.30928219
110DAPK30.30202815
111PRKDC0.28187991
112STK40.27924822
113ABL20.27816485
114RPS6KA10.24438645
115MAPK90.24435550
116LIMK10.24382303
117CSF1R0.24342595
118RAF10.23216516
119DYRK20.23078438
120EIF2AK20.21559484
121JAK30.21084038
122MAP3K50.20689903

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.02915012
2Mismatch repair_Homo sapiens_hsa034303.91719650
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.73911542
4Ribosome_Homo sapiens_hsa030103.60866635
5RNA polymerase_Homo sapiens_hsa030203.45546363
6Spliceosome_Homo sapiens_hsa030403.43055144
7Proteasome_Homo sapiens_hsa030503.29051867
8RNA transport_Homo sapiens_hsa030133.15563873
9Base excision repair_Homo sapiens_hsa034103.10662970
10One carbon pool by folate_Homo sapiens_hsa006702.90529858
11Pyrimidine metabolism_Homo sapiens_hsa002402.73793662
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.64535622
13Nucleotide excision repair_Homo sapiens_hsa034202.54745477
14Homologous recombination_Homo sapiens_hsa034402.53998652
15Cell cycle_Homo sapiens_hsa041102.35498782
16Folate biosynthesis_Homo sapiens_hsa007901.68347366
17RNA degradation_Homo sapiens_hsa030181.63941819
18Fanconi anemia pathway_Homo sapiens_hsa034601.62551368
19Sulfur relay system_Homo sapiens_hsa041221.56125283
20mRNA surveillance pathway_Homo sapiens_hsa030151.51223281
21p53 signaling pathway_Homo sapiens_hsa041151.44714094
22Purine metabolism_Homo sapiens_hsa002301.36079790
23Biosynthesis of amino acids_Homo sapiens_hsa012301.35689982
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.33775771
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33083292
26Non-homologous end-joining_Homo sapiens_hsa034501.32312797
27Basal transcription factors_Homo sapiens_hsa030221.31451289
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.23656686
29Vitamin B6 metabolism_Homo sapiens_hsa007501.19960329
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18010673
31Epstein-Barr virus infection_Homo sapiens_hsa051691.17340046
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.12895347
33Pentose phosphate pathway_Homo sapiens_hsa000301.11949460
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04768838
35Selenocompound metabolism_Homo sapiens_hsa004501.04330763
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01041470
37Carbon metabolism_Homo sapiens_hsa012000.86031231
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85861106
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83291656
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81165660
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80110770
42Viral carcinogenesis_Homo sapiens_hsa052030.79106389
43Systemic lupus erythematosus_Homo sapiens_hsa053220.79065462
44Fructose and mannose metabolism_Homo sapiens_hsa000510.77353874
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77352087
46Herpes simplex infection_Homo sapiens_hsa051680.73803660
47Oocyte meiosis_Homo sapiens_hsa041140.71751612
48Parkinsons disease_Homo sapiens_hsa050120.71671875
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71542907
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69860717
51HTLV-I infection_Homo sapiens_hsa051660.68759923
52Thyroid cancer_Homo sapiens_hsa052160.66111888
53Antigen processing and presentation_Homo sapiens_hsa046120.65871547
54Galactose metabolism_Homo sapiens_hsa000520.62275696
55N-Glycan biosynthesis_Homo sapiens_hsa005100.60770341
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56048700
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55916094
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.52489309
59Fatty acid elongation_Homo sapiens_hsa000620.51966257
60Oxidative phosphorylation_Homo sapiens_hsa001900.50391814
61Glutathione metabolism_Homo sapiens_hsa004800.48552126
62Steroid biosynthesis_Homo sapiens_hsa001000.48200645
63Pancreatic cancer_Homo sapiens_hsa052120.47942066
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47551555
65Small cell lung cancer_Homo sapiens_hsa052220.45939434
66Bladder cancer_Homo sapiens_hsa052190.45745993
67Legionellosis_Homo sapiens_hsa051340.45429905
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42780779
69Chronic myeloid leukemia_Homo sapiens_hsa052200.40262857
70Protein export_Homo sapiens_hsa030600.39780092
71MicroRNAs in cancer_Homo sapiens_hsa052060.39249277
72Acute myeloid leukemia_Homo sapiens_hsa052210.38659313
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37515339
74Apoptosis_Homo sapiens_hsa042100.37007987
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36111174
76Other glycan degradation_Homo sapiens_hsa005110.34400514
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33369827
78Shigellosis_Homo sapiens_hsa051310.31552938
79Primary immunodeficiency_Homo sapiens_hsa053400.30568483
80Basal cell carcinoma_Homo sapiens_hsa052170.30499076
81Colorectal cancer_Homo sapiens_hsa052100.29491130
82Hepatitis B_Homo sapiens_hsa051610.28874477
83Prostate cancer_Homo sapiens_hsa052150.28318901
84Arginine and proline metabolism_Homo sapiens_hsa003300.27869249
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27017805
86Hippo signaling pathway_Homo sapiens_hsa043900.25729709
87mTOR signaling pathway_Homo sapiens_hsa041500.24896310
88Renin-angiotensin system_Homo sapiens_hsa046140.24591150
89Metabolic pathways_Homo sapiens_hsa011000.24412163
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24161699
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23991235
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23664081
93Sulfur metabolism_Homo sapiens_hsa009200.23482707
94Arginine biosynthesis_Homo sapiens_hsa002200.23336709
95Notch signaling pathway_Homo sapiens_hsa043300.22769479
96HIF-1 signaling pathway_Homo sapiens_hsa040660.22541253
97Alzheimers disease_Homo sapiens_hsa050100.21763231
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21033831
99Alcoholism_Homo sapiens_hsa050340.19927919
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.19780152
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18366070
102Endometrial cancer_Homo sapiens_hsa052130.17593027
103Non-small cell lung cancer_Homo sapiens_hsa052230.15336376
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.13622858
105Lysine degradation_Homo sapiens_hsa003100.11761571
106Measles_Homo sapiens_hsa051620.08691753
107Huntingtons disease_Homo sapiens_hsa050160.07765940
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.07577119
109Pathways in cancer_Homo sapiens_hsa052000.06807157
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.06310562
111Pyruvate metabolism_Homo sapiens_hsa006200.04961631
112TGF-beta signaling pathway_Homo sapiens_hsa043500.04926492
113Hedgehog signaling pathway_Homo sapiens_hsa043400.04302296
114Insulin signaling pathway_Homo sapiens_hsa049100.03803345
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.03765771
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.02946659
117Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.01859591
118B cell receptor signaling pathway_Homo sapiens_hsa046620.01144482

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