WDR38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right pattern formation (GO:0060972)9.42945430
2viral transcription (GO:0019083)8.00467552
3regulation of cilium movement (GO:0003352)7.72115536
4translational termination (GO:0006415)7.63645503
5ribosomal small subunit biogenesis (GO:0042274)7.61721904
6primary alcohol catabolic process (GO:0034310)7.45777026
7vitamin transmembrane transport (GO:0035461)6.85937665
8ventricular system development (GO:0021591)6.82300647
9left/right axis specification (GO:0070986)6.79170807
10ribosomal small subunit assembly (GO:0000028)6.67946916
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.61063611
12maturation of SSU-rRNA (GO:0030490)6.52739004
13cotranslational protein targeting to membrane (GO:0006613)6.50238935
14protein targeting to ER (GO:0045047)6.47810629
15microtubule bundle formation (GO:0001578)6.47568052
16translational elongation (GO:0006414)6.39388873
17ribosomal large subunit biogenesis (GO:0042273)6.38588991
18ethanol metabolic process (GO:0006067)6.31295038
19intraciliary transport (GO:0042073)6.19332466
20establishment of protein localization to endoplasmic reticulum (GO:0072599)6.15368800
21protein localization to endoplasmic reticulum (GO:0070972)6.05912081
22viral life cycle (GO:0019058)6.05086112
23cellular protein complex disassembly (GO:0043624)6.03925562
24DNA deamination (GO:0045006)5.95644793
25cilium organization (GO:0044782)5.93280176
26diterpenoid biosynthetic process (GO:0016102)5.86394818
27cilium assembly (GO:0042384)5.76452299
28nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.71261670
29translational initiation (GO:0006413)5.64110010
30tolerance induction (GO:0002507)5.49746629
31one-carbon compound transport (GO:0019755)5.47558365
32centriole assembly (GO:0098534)5.47208888
33pyrimidine-containing compound transmembrane transport (GO:0072531)5.40248366
34lung epithelium development (GO:0060428)5.29891214
35protein complex disassembly (GO:0043241)5.27228819
36response to xenobiotic stimulus (GO:0009410)5.25244068
37establishment of apical/basal cell polarity (GO:0035089)5.11275536
38sperm capacitation (GO:0048240)5.11015432
39macromolecular complex disassembly (GO:0032984)5.00742143
40negative regulation of T cell differentiation in thymus (GO:0033085)5.00332286
41glomerular epithelial cell development (GO:0072310)4.92683282
42protein localization to cilium (GO:0061512)4.87721113
43negative regulation of immunoglobulin mediated immune response (GO:0002890)4.74430900
44negative regulation of B cell mediated immunity (GO:0002713)4.74430900
45microtubule-based movement (GO:0007018)4.65918971
46ethanol oxidation (GO:0006069)4.62153299
47ribonucleoprotein complex biogenesis (GO:0022613)4.60612600
48proteasome assembly (GO:0043248)4.59006667
49regulation of interleukin-5 production (GO:0032674)4.58878372
50translation (GO:0006412)4.57049047
51cellular component assembly involved in morphogenesis (GO:0010927)4.54336066
52regulation of microtubule-based movement (GO:0060632)4.49853567
53negative regulation of humoral immune response (GO:0002921)4.49087181
54establishment of monopolar cell polarity (GO:0061162)4.40501297
55establishment or maintenance of monopolar cell polarity (GO:0061339)4.40501297
56regulation of germinal center formation (GO:0002634)4.38919378
57positive regulation of tolerance induction (GO:0002645)4.36043320
58negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.35958832
59transcription elongation from RNA polymerase III promoter (GO:0006385)4.21258050
60termination of RNA polymerase III transcription (GO:0006386)4.21258050
61cell projection assembly (GO:0030031)4.20717249
62nuclear-transcribed mRNA catabolic process (GO:0000956)4.18375269
63cilium morphogenesis (GO:0060271)4.17799911
64regulation of interleukin-13 production (GO:0032656)4.17184010
65protein targeting to membrane (GO:0006612)4.12220678
66terpenoid biosynthetic process (GO:0016114)4.08337069
67microtubule depolymerization (GO:0007019)3.99283616
68mRNA catabolic process (GO:0006402)3.97316638
69nucleoside diphosphate phosphorylation (GO:0006165)3.95645586
70retinoic acid metabolic process (GO:0042573)3.91237490
71cytoplasmic microtubule organization (GO:0031122)3.87003714
72spliceosomal snRNP assembly (GO:0000387)3.76869711
73rRNA processing (GO:0006364)3.76470950
74microtubule polymerization or depolymerization (GO:0031109)3.72106430
75cellular component biogenesis (GO:0044085)3.72015870
76spliceosomal complex assembly (GO:0000245)3.70262821
77RNA catabolic process (GO:0006401)3.68050882
78GTP biosynthetic process (GO:0006183)3.67298702
79DNA damage response, detection of DNA damage (GO:0042769)3.66841364
80negative regulation of inclusion body assembly (GO:0090084)3.66177741
81rRNA metabolic process (GO:0016072)3.63260415
82exogenous drug catabolic process (GO:0042738)3.60091928
83establishment of planar polarity (GO:0001736)3.46715489
84establishment of tissue polarity (GO:0007164)3.46715489
85DNA replication checkpoint (GO:0000076)3.42188879
86lateral ventricle development (GO:0021670)3.35982598
87primary alcohol metabolic process (GO:0034308)3.35974959
88telomere maintenance via semi-conservative replication (GO:0032201)3.35262096
89regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.32970487
907-methylguanosine mRNA capping (GO:0006370)3.27524509
91transcription-coupled nucleotide-excision repair (GO:0006283)3.27513328
92deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.27401354
93O-glycan processing (GO:0016266)3.27066014
94regulation of tolerance induction (GO:0002643)3.25827206
95retinol metabolic process (GO:0042572)3.22797704
967-methylguanosine RNA capping (GO:0009452)3.20248817
97RNA capping (GO:0036260)3.20248817
98UTP biosynthetic process (GO:0006228)3.19161788
99glutathione derivative metabolic process (GO:1901685)3.18313809
100glutathione derivative biosynthetic process (GO:1901687)3.18313809
101sperm motility (GO:0030317)3.18195752
102DNA strand elongation involved in DNA replication (GO:0006271)3.13874707
103regulation of microtubule depolymerization (GO:0031114)3.12331112
104exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11567635
105positive regulation of smoothened signaling pathway (GO:0045880)3.11340363
106CENP-A containing nucleosome assembly (GO:0034080)3.10016363
107multicellular organismal water homeostasis (GO:0050891)3.09702446
108phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.08226701
109hydrogen peroxide biosynthetic process (GO:0050665)3.05689865
110termination of RNA polymerase I transcription (GO:0006363)3.05684991
111nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04879696
112chromatin remodeling at centromere (GO:0031055)3.04528050
113regulation of mitochondrial translation (GO:0070129)3.03639948
114aldehyde catabolic process (GO:0046185)3.02454929
115DNA strand elongation (GO:0022616)3.00114456
116axonemal dynein complex assembly (GO:0070286)22.5959366
117regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.99496690
118negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.98918741
119telomere maintenance via recombination (GO:0000722)2.98306405
120rRNA modification (GO:0000154)2.98003024
121transcription from RNA polymerase I promoter (GO:0006360)2.97007339
122transcription elongation from RNA polymerase I promoter (GO:0006362)2.95289382
123DNA catabolic process, exonucleolytic (GO:0000738)2.92320192
124guanosine-containing compound biosynthetic process (GO:1901070)2.89829353
125pseudouridine synthesis (GO:0001522)2.85796242
126carnitine metabolic process (GO:0009437)2.84714002
127establishment of protein localization to membrane (GO:0090150)2.83419969
128ribosome biogenesis (GO:0042254)2.82749584
129centriole replication (GO:0007099)2.82275124
130determination of left/right symmetry (GO:0007368)2.80820961
131DNA ligation (GO:0006266)2.80580127
132pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.80403623
133ncRNA processing (GO:0034470)2.79348112
134microtubule-based process (GO:0007017)2.78028115
135DNA-templated transcription, termination (GO:0006353)2.77929821
136regulation of double-strand break repair via homologous recombination (GO:0010569)2.77486358
137establishment of integrated proviral latency (GO:0075713)2.77345584
138drug catabolic process (GO:0042737)2.76989556
139positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.75960521
140excretion (GO:0007588)2.75171426
141sequestering of actin monomers (GO:0042989)2.75007982
142lateral sprouting from an epithelium (GO:0060601)2.74271827
143CTP biosynthetic process (GO:0006241)2.73605822
144CTP metabolic process (GO:0046036)2.73605822
145DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.73504302
146establishment of viral latency (GO:0019043)2.73218586
147hydrogen peroxide catabolic process (GO:0042744)2.72987873
148negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.72198384
149negative regulation of ligase activity (GO:0051352)2.72198384
150DNA replication initiation (GO:0006270)2.70992030
151reactive oxygen species biosynthetic process (GO:1903409)2.70960548
152protein targeting (GO:0006605)2.70893950
153apical protein localization (GO:0045176)2.70699531
154signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.70375822
155signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.70375822
156signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.70375822
157deoxyribonucleotide biosynthetic process (GO:0009263)2.70362975
158hypotonic response (GO:0006971)2.70196286
159regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.69399332
160pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.69291274
161determination of bilateral symmetry (GO:0009855)2.69176288
162telomere maintenance via telomere lengthening (GO:0010833)2.67995429
163anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.67336870
164pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.67121398
165signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.66916358
166intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.66916358
167mitotic recombination (GO:0006312)2.66613406
168water homeostasis (GO:0030104)2.66439156
169antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.66025849
170ncRNA metabolic process (GO:0034660)2.65940302
171viral mRNA export from host cell nucleus (GO:0046784)2.65263133
172tRNA modification (GO:0006400)2.65200063
173signal transduction involved in DNA integrity checkpoint (GO:0072401)2.64590800
174signal transduction involved in DNA damage checkpoint (GO:0072422)2.64590800
175signal transduction involved in cell cycle checkpoint (GO:0072395)2.64441874
176establishment of protein localization to organelle (GO:0072594)2.63581054
177nucleotide-excision repair, DNA gap filling (GO:0006297)2.63433930
178specification of symmetry (GO:0009799)2.63421978
179pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.63232520
180phosphatidylcholine biosynthetic process (GO:0006656)2.62937270
181oligosaccharide biosynthetic process (GO:0009312)2.61092104
182smoothened signaling pathway (GO:0007224)2.59184186
183progesterone metabolic process (GO:0042448)2.58413084
184organelle assembly (GO:0070925)2.58168339
185regulation of response to osmotic stress (GO:0047484)2.57330387
186calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.56008567
187regulation of autophagic vacuole assembly (GO:2000785)2.55494402
188regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.55452616
189negative regulation of microtubule depolymerization (GO:0007026)2.53716173
190establishment or maintenance of apical/basal cell polarity (GO:0035088)2.49630928
191establishment or maintenance of bipolar cell polarity (GO:0061245)2.49630928
192polyol transport (GO:0015791)2.47151646
193regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.44882922
194dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.44233090
195cilium or flagellum-dependent cell motility (GO:0001539)18.1640266
196cilium movement (GO:0003341)15.8320167
197motile cilium assembly (GO:0044458)15.4469904
198epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)14.1853551
199epithelial cilium movement (GO:0003351)13.8139140
200axoneme assembly (GO:0035082)10.1835588

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.80934665
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.47330989
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.31681533
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.09364285
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.04627861
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.86127881
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.58688922
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.50253105
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.47810151
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.44899921
11DROSHA_22980978_ChIP-Seq_HELA_Human3.42827580
12FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.29436407
13MYC_19079543_ChIP-ChIP_MESCs_Mouse3.20451725
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.98471445
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.96682864
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.81273498
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.80713115
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.80696832
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.74807814
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73191549
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.72980691
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.69737104
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.62412647
24TRIM28_21343339_ChIP-Seq_HEK293_Human2.61809180
25XRN2_22483619_ChIP-Seq_HELA_Human2.58855390
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.55193925
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.54396109
28VDR_23849224_ChIP-Seq_CD4+_Human2.51972573
29TTF2_22483619_ChIP-Seq_HELA_Human2.51097475
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.50210575
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.39463512
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.38256165
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.22856921
34FOXP3_21729870_ChIP-Seq_TREG_Human2.21142374
35SMC4_20622854_ChIP-Seq_HELA_Human2.21069453
36DCP1A_22483619_ChIP-Seq_HELA_Human2.19985112
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.15225848
38ESR1_20079471_ChIP-ChIP_T-47D_Human2.13834219
39RUNX1_27514584_Chip-Seq_MCF-7_Human2.13413994
40ESR2_21235772_ChIP-Seq_MCF-7_Human2.10526766
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.09978514
42YY1_21170310_ChIP-Seq_MESCs_Mouse2.08899186
43E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06890238
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.99883417
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.99738399
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.99551368
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.94149610
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.93088610
49ELK1_19687146_ChIP-ChIP_HELA_Human1.92626192
50SOX2_27498859_Chip-Seq_STOMACH_Mouse1.89025895
51* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80243089
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79064829
53AHR_22903824_ChIP-Seq_MCF-7_Human1.77484337
54FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.75376170
55ELF1_20517297_ChIP-Seq_JURKAT_Human1.75237205
56CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.74089994
57TP63_22573176_ChIP-Seq_HFKS_Human1.73171957
58KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.72800483
59FOXM1_23109430_ChIP-Seq_U2OS_Human1.72553914
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72482818
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.72004899
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71181606
63P63_26484246_Chip-Seq_KERATINOCYTES_Human1.70675697
64MYC_18940864_ChIP-ChIP_HL60_Human1.69085599
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.67934518
66SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.67056891
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66432670
68P68_20966046_ChIP-Seq_HELA_Human1.65954631
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.62369985
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61929937
71GABP_19822575_ChIP-Seq_HepG2_Human1.57366357
72* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.57093307
73KLF5_25053715_ChIP-Seq_YYC3_Human1.56856344
74TDRD3_21172665_ChIP-Seq_MCF-7_Human1.56290300
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55574197
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.54887837
77CTCF_27219007_Chip-Seq_Bcells_Human1.52998168
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.50671039
79KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.50602145
80RACK7_27058665_Chip-Seq_MCF-7_Human1.50362477
81TP63_23658742_ChIP-Seq_EP156T_Human1.49860009
82AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.49554736
83ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.46428203
84GATA1_19941826_ChIP-Seq_K562_Human1.46387320
85ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46313758
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.44952710
87SOX9_24532713_ChIP-Seq_HFSC_Mouse1.44250717
88* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.43658351
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43657221
90HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43081300
91NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42198844
92PHF8_20622854_ChIP-Seq_HELA_Human1.40642598
93CTCF_20526341_ChIP-Seq_ESCs_Human1.39647934
94FOXM1_26456572_ChIP-Seq_MCF-7_Human1.37754952
95SOX2_20726797_ChIP-Seq_SW620_Human1.35639426
96CREB1_26743006_Chip-Seq_LNCaP_Human1.35095121
97LXR_22292898_ChIP-Seq_THP-1_Human1.33997801
98POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33623282
99PIAS1_25552417_ChIP-Seq_VCAP_Human1.33019941
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32889165
101ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.29398095
102CDX2_20551321_ChIP-Seq_CACO-2_Human1.28946614
103CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27839994
104STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27624718
105ETV1_20927104_ChIP-Seq_GIST48_Human1.24604506
106FOXA1_25552417_ChIP-Seq_VCAP_Human1.23565227
107E2F1_20622854_ChIP-Seq_HELA_Human1.21956116
108ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21242444
109SMRT_27268052_Chip-Seq_Bcells_Human1.18902244
110SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18616704
111ZNF263_19887448_ChIP-Seq_K562_Human1.18525831
112ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18275693
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.18036767
114* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.18032196
115PHF8_20622853_ChIP-Seq_HELA_Human1.17697712
116TP63_17297297_ChIP-ChIP_HaCaT_Human1.17590560
117PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17197987
118FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16884488
119BCOR_27268052_Chip-Seq_Bcells_Human1.16628188
120CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.16490355
121HNFA_21074721_ChIP-Seq_CACO-2_Human1.15699250
122P300_27268052_Chip-Seq_Bcells_Human1.15378203
123PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.15051108
124YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15028698
125KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13656967
126NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13605200
127TP53_18474530_ChIP-ChIP_U2OS_Human1.13388079
128POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11094622
129MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10966311
130GATA3_24758297_ChIP-Seq_MCF-7_Human1.09982484
131SA1_27219007_Chip-Seq_ERYTHROID_Human1.09299422
132TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08083002
133* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.07790843
134IRF1_19129219_ChIP-ChIP_H3396_Human1.06792318
135GATA4_25053715_ChIP-Seq_YYC3_Human1.06645364
136SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05697898
137FOXO3_23340844_ChIP-Seq_DLD1_Human1.04868124
138RBPJ_21746931_ChIP-Seq_IB4_Human1.04512959
139CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03256551
140BCL6_27268052_Chip-Seq_Bcells_Human1.03219005
141CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01454100
142CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01428641
143FLI1_21867929_ChIP-Seq_CD8_Mouse1.00431108
144GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00303520
145GATA6_21074721_ChIP-Seq_CACO-2_Human1.00122544
146SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99734007
147HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99034908
148CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99024873
149VDR_22108803_ChIP-Seq_LS180_Human0.98057666
150PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97781044
151FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.97405071
152DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97178544
153CIITA_25753668_ChIP-Seq_RAJI_Human0.96920648
154EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96592177
155CEBPB_22108803_ChIP-Seq_LS180_Human0.96502223
156CBX2_22325352_ChIP-Seq_293T-Rex_Human0.95839731
157STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95400192
158YY1_22570637_ChIP-Seq_MALME-3M_Human0.95025207
159KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.94524333
160KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.94524333
161KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.94524333
162IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94511711
163RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93458615
164FOXA2_19822575_ChIP-Seq_HepG2_Human0.92546827
165RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92405373
166SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92166371
167* SOX2_21211035_ChIP-Seq_LN229_Human0.91970561
168SPI1_23547873_ChIP-Seq_NB4_Human0.91314910
169E2F1_21310950_ChIP-Seq_MCF-7_Human0.91281983
170PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90711569
171TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90266744
172PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89966778
173GATA2_19941826_ChIP-Seq_K562_Human0.89938578
174P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.89794893
175RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.89515137
176RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89362031
177EZH2_27294783_Chip-Seq_ESCs_Mouse0.89113807
178SA1_27219007_Chip-Seq_Bcells_Human0.88983512
179ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86334686
180FLI1_27457419_Chip-Seq_LIVER_Mouse0.84255728
181PADI4_21655091_ChIP-ChIP_MCF-7_Human0.81668897
182BMI1_23680149_ChIP-Seq_NPCS_Mouse0.81274064
183BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80300462
184STAT4_19710469_ChIP-ChIP_TH1__Mouse0.79140752
185TCF3_18692474_ChIP-Seq_MEFs_Mouse0.76994380
186SOX2_18692474_ChIP-Seq_MEFs_Mouse0.76770663
187SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.76265435
188PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.74462358
189STAT1_20625510_ChIP-Seq_HELA_Human0.72942186
190KDM5A_27292631_Chip-Seq_BREAST_Human0.72310890
191GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.72229367
192NANOG_16153702_ChIP-ChIP_HESCs_Human0.70950498

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok7.01951804
2MP0009379_abnormal_foot_pigmentation6.83004840
3MP0004043_abnormal_pH_regulation4.19168494
4MP0001984_abnormal_olfaction3.79580538
5MP0009780_abnormal_chondrocyte_physiolo3.69214288
6MP0005623_abnormal_meninges_morphology3.51208940
7MP0006292_abnormal_olfactory_placode3.35027586
8MP0003693_abnormal_embryo_hatching3.22800316
9MP0004381_abnormal_hair_follicle3.22439456
10MP0003136_yellow_coat_color3.11334017
11MP0001188_hyperpigmentation2.69997151
12MP0002102_abnormal_ear_morphology2.69835265
13MP0005377_hearing/vestibular/ear_phenot2.65961493
14MP0003878_abnormal_ear_physiology2.65961493
15MP0003941_abnormal_skin_development2.62335073
16MP0008058_abnormal_DNA_repair2.55649692
17MP0000566_synostosis2.33135422
18MP0008932_abnormal_embryonic_tissue2.28563698
19MP0003111_abnormal_nucleus_morphology2.24608371
20MP0005083_abnormal_biliary_tract2.21426636
21MP0004957_abnormal_blastocyst_morpholog2.19978624
22MP0004019_abnormal_vitamin_homeostasis2.16822719
23MP0003786_premature_aging2.15235200
24MP0008007_abnormal_cellular_replicative2.15070801
25MP0010094_abnormal_chromosome_stability2.13622520
26MP0000383_abnormal_hair_follicle2.09939086
27MP0005174_abnormal_tail_pigmentation2.06429630
28MP0002132_abnormal_respiratory_system2.03704040
29MP0002168_other_aberrant_phenotype2.00248039
30MP0002282_abnormal_trachea_morphology1.95954457
31MP0001765_abnormal_ion_homeostasis1.94005090
32MP0002277_abnormal_respiratory_mucosa1.92664920
33MP0010678_abnormal_skin_adnexa1.92602993
34MP0005409_darkened_coat_color1.92064470
35MP0003656_abnormal_erythrocyte_physiolo1.89554167
36MP0003077_abnormal_cell_cycle1.86789424
37MP0010030_abnormal_orbit_morphology1.83198422
38MP0003718_maternal_effect1.69478522
39MP0010234_abnormal_vibrissa_follicle1.67635336
40MP0003315_abnormal_perineum_morphology1.67465785
41MP0002638_abnormal_pupillary_reflex1.62865045
42MP0008057_abnormal_DNA_replication1.62612382
43MP0002909_abnormal_adrenal_gland1.60215426
44MP0003763_abnormal_thymus_physiology1.58846143
45MP0000049_abnormal_middle_ear1.56976075
46MP0008995_early_reproductive_senescence1.56960522
47MP0008789_abnormal_olfactory_epithelium1.56114059
48MP0000015_abnormal_ear_pigmentation1.41653275
49MP0002095_abnormal_skin_pigmentation1.41171051
50MP0008877_abnormal_DNA_methylation1.38253617
51MP0003938_abnormal_ear_development1.35953545
52MP0005395_other_phenotype1.34594943
53MP0003724_increased_susceptibility_to1.32470751
54MP0002163_abnormal_gland_morphology1.29526610
55MP0002751_abnormal_autonomic_nervous1.29498435
56MP0005165_increased_susceptibility_to1.28698279
57MP0002938_white_spotting1.27528313
58MP0001986_abnormal_taste_sensitivity1.27169444
59MP0002148_abnormal_hypersensitivity_rea1.26145190
60MP0010155_abnormal_intestine_physiology1.25429947
61MP0005075_abnormal_melanosome_morpholog1.25388214
62MP0005636_abnormal_mineral_homeostasis1.25346834
63MP0000372_irregular_coat_pigmentation1.24431456
64MP0003011_delayed_dark_adaptation1.24105451
65MP0002796_impaired_skin_barrier1.20807669
66MP0004133_heterotaxia1.19581965
67MP0005248_abnormal_Harderian_gland1.18427947
68MP0000613_abnormal_salivary_gland1.17994646
69MP0009333_abnormal_splenocyte_physiolog1.17340484
70MP0005501_abnormal_skin_physiology1.17170108
71MP0001919_abnormal_reproductive_system1.15123820
72MP0005671_abnormal_response_to1.12461285
73MP0000490_abnormal_crypts_of1.11529299
74MP0000465_gastrointestinal_hemorrhage1.11522328
75MP0002177_abnormal_outer_ear1.09652255
76MP0002210_abnormal_sex_determination1.04565846
77MP0000858_altered_metastatic_potential1.04499421
78MP0002734_abnormal_mechanical_nocicepti1.02979084
79MP0002098_abnormal_vibrissa_morphology1.01919163
80MP0002160_abnormal_reproductive_system1.00407376
81MP0002249_abnormal_larynx_morphology0.99938622
82MP0001849_ear_inflammation0.98756630
83MP0003303_peritoneal_inflammation0.97693503
84MP0005499_abnormal_olfactory_system0.97361388
85MP0005394_taste/olfaction_phenotype0.97361388
86MP0003453_abnormal_keratinocyte_physiol0.95111551
87MP0002233_abnormal_nose_morphology0.93554216
88MP0005389_reproductive_system_phenotype0.93506426
89MP0002735_abnormal_chemical_nociception0.93460812
90MP0009643_abnormal_urine_homeostasis0.93402020
91MP0001286_abnormal_eye_development0.92518212
92MP0004264_abnormal_extraembryonic_tissu0.92375092
93MP0005365_abnormal_bile_salt0.90464519
94MP0005379_endocrine/exocrine_gland_phen0.89795712
95MP0002136_abnormal_kidney_physiology0.88868156
96MP0000762_abnormal_tongue_morphology0.88511036
97MP0009785_altered_susceptibility_to0.88425971
98MP0002876_abnormal_thyroid_physiology0.88349790
99MP0001346_abnormal_lacrimal_gland0.87756635
100MP0001485_abnormal_pinna_reflex0.87695289
101MP0006072_abnormal_retinal_apoptosis0.87256873
102MP0001835_abnormal_antigen_presentation0.86586716
103MP0005000_abnormal_immune_tolerance0.85632446
104MP0000681_abnormal_thyroid_gland0.85189640
105MP0006276_abnormal_autonomic_nervous0.81724637
106MP0000703_abnormal_thymus_morphology0.80597094
107MP0005164_abnormal_response_to0.79698799
108MP0003698_abnormal_male_reproductive0.78308179
109MP0005408_hypopigmentation0.78203358
110MP0005257_abnormal_intraocular_pressure0.77819641
111MP0003436_decreased_susceptibility_to0.77306208
112MP0003828_pulmonary_edema0.77245654
113MP0000026_abnormal_inner_ear0.75942442
114MP0001145_abnormal_male_reproductive0.75684828
115MP0004142_abnormal_muscle_tone0.74752755
116MP0001529_abnormal_vocalization0.73924682
117MP0000678_abnormal_parathyroid_gland0.73638746
118MP0000313_abnormal_cell_death0.73508448
119MP0001929_abnormal_gametogenesis0.72200999
120MP0001502_abnormal_circadian_rhythm0.71585309
121MP0001542_abnormal_bone_strength0.71319726
122MP0009250_abnormal_appendicular_skeleto0.71153681
123MP0005220_abnormal_exocrine_pancreas0.71058453
124MP0002405_respiratory_system_inflammati0.70767941
125MP0000350_abnormal_cell_proliferation0.70123682
126MP0005025_abnormal_response_to0.70076931
127MP0005410_abnormal_fertilization0.69652474
128MP0000653_abnormal_sex_gland0.68233436
129MP0002420_abnormal_adaptive_immunity0.68041904
130MP0001819_abnormal_immune_cell0.67214428
131MP0002723_abnormal_immune_serum0.66673427
132MP0005084_abnormal_gallbladder_morpholo0.65741311
133MP0008004_abnormal_stomach_pH0.65288826
134MP0002653_abnormal_ependyma_morphology0.64644237
135MP0002452_abnormal_antigen_presenting0.63850693
136MP0005310_abnormal_salivary_gland0.63589347
137MP0002722_abnormal_immune_system0.63503672
138MP0002019_abnormal_tumor_incidence0.63174845
139MP0004883_abnormal_blood_vessel0.63063833
140MP0009765_abnormal_xenobiotic_induced0.62951004
141MP0001800_abnormal_humoral_immune0.62787377
142MP0005085_abnormal_gallbladder_physiolo0.62353992
143MP0000467_abnormal_esophagus_morphology0.62067064
144MP0002139_abnormal_hepatobiliary_system0.61259519
145MP0003385_abnormal_body_wall0.61114966
146MP0001119_abnormal_female_reproductive0.60762898
147MP0001324_abnormal_eye_pigmentation0.59482369
148MP0001293_anophthalmia0.57649447
149MP0003075_altered_response_to0.55793134
150MP0001664_abnormal_digestion0.55603092
151MP0009763_increased_sensitivity_to0.51925404
152MP0001270_distended_abdomen0.50612035
153MP0002896_abnormal_bone_mineralization0.50038612
154MP0001663_abnormal_digestive_system0.49742995
155MP0003806_abnormal_nucleotide_metabolis0.49316322
156MP0005023_abnormal_wound_healing0.48496161
157MP0003866_abnormal_defecation0.48282369
158MP0009703_decreased_birth_body0.45982766
159MP0002116_abnormal_craniofacial_bone0.45889614
160MP0005388_respiratory_system_phenotype0.44511205
161MP0002133_abnormal_respiratory_system0.44511205
162MP0001944_abnormal_pancreas_morphology0.44186936
163MP0002161_abnormal_fertility/fecundity0.43386476
164MP0005503_abnormal_tendon_morphology0.43278242
165MP0006082_CNS_inflammation0.43193746
166MP0006036_abnormal_mitochondrial_physio0.42900719
167MP0002135_abnormal_kidney_morphology0.41135042
168MP0009046_muscle_twitch0.40778846
169MP0005253_abnormal_eye_physiology0.39329315
170MP0002084_abnormal_developmental_patter0.39319495
171MP0001299_abnormal_eye_distance/0.39052175
172MP0001963_abnormal_hearing_physiology0.37560404
173MP0005387_immune_system_phenotype0.37530951
174MP0001790_abnormal_immune_system0.37530951

Predicted human phenotypes

RankGene SetZ-score
1Chronic bronchitis (HP:0004469)8.04071128
2Bronchiectasis (HP:0002110)7.49884646
3Nasal polyposis (HP:0100582)7.02196971
4Reticulocytopenia (HP:0001896)6.58903466
5Abnormality of the nasal mucosa (HP:0000433)5.84585102
6Abnormality of cells of the erythroid lineage (HP:0012130)4.98236945
7Macrocytic anemia (HP:0001972)4.86148868
8Abnormal number of erythroid precursors (HP:0012131)4.68065356
9Recurrent sinusitis (HP:0011108)4.39693205
10Infertility (HP:0000789)4.39322570
11Bronchitis (HP:0012387)4.36139435
12Pallor (HP:0000980)4.32407113
13Male infertility (HP:0003251)4.16211191
14Chronic sinusitis (HP:0011109)4.12783858
15Aplasia/Hypoplasia of the sacrum (HP:0008517)4.04979504
16Recurrent otitis media (HP:0000403)3.94510926
17Abnormal hemoglobin (HP:0011902)3.61237791
18Occipital encephalocele (HP:0002085)3.54871823
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.31561862
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.30882365
21Pancreatic fibrosis (HP:0100732)3.28458599
22Mitochondrial inheritance (HP:0001427)3.23897793
23True hermaphroditism (HP:0010459)3.23178325
24Increased hepatocellular lipid droplets (HP:0006565)3.19723689
25Atelectasis (HP:0100750)3.16868899
26Hepatocellular necrosis (HP:0001404)3.09106734
27Triphalangeal thumb (HP:0001199)3.08875465
28Hyperactive renin-angiotensin system (HP:0000841)3.06454145
29Chronic otitis media (HP:0000389)3.06140027
30Concave nail (HP:0001598)2.96637239
31Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.93776704
32Breast hypoplasia (HP:0003187)2.92250337
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.90768849
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.90768849
35Renal Fanconi syndrome (HP:0001994)2.88541258
36Exertional dyspnea (HP:0002875)2.87822634
37Acute necrotizing encephalopathy (HP:0006965)2.82840646
38Absent thumb (HP:0009777)2.77719145
39Cystic liver disease (HP:0006706)2.72496811
40Congenital, generalized hypertrichosis (HP:0004540)2.69573842
41Abnormality of midbrain morphology (HP:0002418)2.65929545
42Molar tooth sign on MRI (HP:0002419)2.65929545
433-Methylglutaconic aciduria (HP:0003535)2.63948014
44Progressive external ophthalmoplegia (HP:0000590)2.62829228
45Nephronophthisis (HP:0000090)2.61450204
46Chromosomal breakage induced by crosslinking agents (HP:0003221)2.59972856
47Parakeratosis (HP:0001036)2.56344807
48Lipid accumulation in hepatocytes (HP:0006561)2.55015815
49Increased CSF lactate (HP:0002490)2.54203688
50Abnormality of the preputium (HP:0100587)2.48759738
5111 pairs of ribs (HP:0000878)2.44623241
52Aplasia/hypoplasia of the uterus (HP:0008684)2.43300431
53Chromsome breakage (HP:0040012)2.43111048
54Abnormal mitochondria in muscle tissue (HP:0008316)2.40746593
55Hepatic necrosis (HP:0002605)2.40698924
56Trismus (HP:0000211)2.39279620
57Abnormal respiratory motile cilium morphology (HP:0005938)2.38398717
58Abnormal respiratory epithelium morphology (HP:0012253)2.38398717
59Horseshoe kidney (HP:0000085)2.36208028
60Chronic hepatic failure (HP:0100626)2.35455325
61Meckel diverticulum (HP:0002245)2.34133431
62Increased serum lactate (HP:0002151)2.29435176
63Postaxial foot polydactyly (HP:0001830)2.29354917
64Depressed nasal ridge (HP:0000457)2.27631084
65Duplicated collecting system (HP:0000081)2.27086213
66Abnormality of the ileum (HP:0001549)2.23335192
67Hypoplasia of the radius (HP:0002984)2.23265747
68Type I transferrin isoform profile (HP:0003642)2.23060095
69Absent radius (HP:0003974)2.20937661
70Sparse eyelashes (HP:0000653)2.19818263
71Progressive macrocephaly (HP:0004481)2.17087560
72Optic disc pallor (HP:0000543)2.15852047
73Abnormal sex determination (HP:0012244)2.13385592
74Sex reversal (HP:0012245)2.13385592
75Abnormal ciliary motility (HP:0012262)2.12064466
76Cleft eyelid (HP:0000625)2.10933531
77Respiratory difficulties (HP:0002880)2.10697928
78Patellar aplasia (HP:0006443)2.07822489
79Bell-shaped thorax (HP:0001591)2.07535092
80Aplasia involving forearm bones (HP:0009822)2.07182806
81Absent forearm bone (HP:0003953)2.07182806
82Secondary amenorrhea (HP:0000869)2.07172195
83Exercise intolerance (HP:0003546)2.05851006
84Oral leukoplakia (HP:0002745)2.05288427
85Microvesicular hepatic steatosis (HP:0001414)2.05128120
86Birth length less than 3rd percentile (HP:0003561)2.03281608
87Aplasia/Hypoplasia of the patella (HP:0006498)2.02923493
88Tubulointerstitial nephritis (HP:0001970)2.02624968
89Asplenia (HP:0001746)2.01980996
90Rough bone trabeculation (HP:0100670)2.01954366
91Abnormality of the renal collecting system (HP:0004742)2.01748085
92Abnormality of the renal medulla (HP:0100957)2.00176017
93Rhinitis (HP:0012384)10.2653264
94Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.99540140
95Congenital hepatic fibrosis (HP:0002612)1.97966528
96Aplastic anemia (HP:0001915)1.97940684
97Congenital ichthyosiform erythroderma (HP:0007431)1.97614665
98Pancreatic cysts (HP:0001737)1.97171724
99Aplasia/Hypoplasia of the uvula (HP:0010293)1.96050953
100Cerebral hypomyelination (HP:0006808)1.95936263
101Dynein arm defect of respiratory motile cilia (HP:0012255)1.95724758
102Absent/shortened dynein arms (HP:0200106)1.95724758
103Obstructive lung disease (HP:0006536)1.94411924
104Chronic obstructive pulmonary disease (HP:0006510)1.94411924
105Increased intramyocellular lipid droplets (HP:0012240)1.93478961
106Decreased circulating renin level (HP:0003351)1.92954949
107Abnormality of secondary sexual hair (HP:0009888)1.92283370
108Abnormality of the axillary hair (HP:0100134)1.92283370
109Anencephaly (HP:0002323)1.91749518
110Dry hair (HP:0011359)1.91526286
111Amniotic constriction ring (HP:0009775)1.91399195
112Abnormality of placental membranes (HP:0011409)1.91399195
113Premature graying of hair (HP:0002216)1.91007529
114Absent rod-and cone-mediated responses on ERG (HP:0007688)1.89853754
115Absent frontal sinuses (HP:0002688)1.89429504
116Acute encephalopathy (HP:0006846)1.89024829
117Fragile nails (HP:0001808)1.86876289
118Stomatitis (HP:0010280)1.85601917
119Microretrognathia (HP:0000308)1.84647026
120Aplasia/Hypoplasia of the tongue (HP:0010295)1.84426232
121Abnormal respiratory motile cilium physiology (HP:0012261)1.84353896
122Colon cancer (HP:0003003)1.84151045
123Muscle fiber atrophy (HP:0100295)1.83723694
124Duplication of thumb phalanx (HP:0009942)1.83218655
125Recurrent bronchitis (HP:0002837)1.83186397
126Renal salt wasting (HP:0000127)1.82683368
127Abnormality of renal resorption (HP:0011038)1.82109011
128Male pseudohermaphroditism (HP:0000037)1.81675856
129Aplasia/Hypoplasia of the spleen (HP:0010451)1.79179890
130Abdominal situs inversus (HP:0003363)1.79051344
131Abnormality of abdominal situs (HP:0011620)1.79051344
132Supernumerary spleens (HP:0009799)1.76804963
133Seborrheic dermatitis (HP:0001051)1.75188274
134Pancytopenia (HP:0001876)1.75091479
135Medial flaring of the eyebrow (HP:0010747)1.68733927
136Hyperkalemia (HP:0002153)1.67046769
137Tubular atrophy (HP:0000092)1.64742373
138Nephropathy (HP:0000112)1.61381448
139Oculomotor apraxia (HP:0000657)1.57064713
140Congenital primary aphakia (HP:0007707)1.56496758
141Sclerocornea (HP:0000647)1.56233893
142Furrowed tongue (HP:0000221)1.55962314
143Gait imbalance (HP:0002141)1.53338633
144Hyperaldosteronism (HP:0000859)1.48539851
145Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.48258899
146Postaxial hand polydactyly (HP:0001162)1.42739192
147Abnormality of renin-angiotensin system (HP:0000847)1.41810625
148Abnormality of chloride homeostasis (HP:0011422)1.37780129
149Fetal akinesia sequence (HP:0001989)1.35628745
150Nephrogenic diabetes insipidus (HP:0009806)1.35285023
151Popliteal pterygium (HP:0009756)1.33146000
152Aplasia of the musculature (HP:0100854)1.31052450
153Abnormality of the distal phalanges of the toes (HP:0010182)1.29137998
154Short thorax (HP:0010306)1.28048443
155Hand muscle atrophy (HP:0009130)1.27174753
156Median cleft lip (HP:0000161)1.26749127
157Short nail (HP:0001799)1.25322656
158Hypokalemic alkalosis (HP:0001949)1.24787497
159Hyponatremia (HP:0002902)1.23839823
160Preaxial hand polydactyly (HP:0001177)1.23393485
161Decreased central vision (HP:0007663)1.19982813
162Glucose intolerance (HP:0000833)1.19893866
163Abnormality of the frontal sinuses (HP:0002687)1.18333435
164Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.18243390
165Abnormality of permanent molar morphology (HP:0011071)1.17779072
166Abnormality of the dental root (HP:0006486)1.17779072
167Taurodontia (HP:0000679)1.17779072
168Stage 5 chronic kidney disease (HP:0003774)1.15321657
169Tubulointerstitial abnormality (HP:0001969)1.13893123
170Bifid scrotum (HP:0000048)1.12989322
171Lip pit (HP:0100267)1.11701868
172Cone-rod dystrophy (HP:0000548)1.10378491
173Obstructive sleep apnea (HP:0002870)1.09537984
174Short femoral neck (HP:0100864)1.08587045
175Abnormality of molar morphology (HP:0011070)1.07708150
176Abnormality of molar (HP:0011077)1.07708150
177Poor coordination (HP:0002370)1.05447060
178Abnormality of the dental pulp (HP:0006479)1.04162670
179Flat acetabular roof (HP:0003180)1.03169491
180Abnormality of monocarboxylic acid metabolism (HP:0010996)1.03082231
181Vaginal atresia (HP:0000148)1.01745449
182Polydipsia (HP:0001959)1.01098668
183Abnormal drinking behavior (HP:0030082)1.01098668
184Genital tract atresia (HP:0001827)1.00616926
185Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)0.98816774
186Muscle fiber splitting (HP:0003555)0.98554481
187Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)0.98091075
188Carpal bone hypoplasia (HP:0001498)0.93900178
189Stridor (HP:0010307)0.93847278

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK16.75695342
2STK163.93606344
3BUB13.50048910
4SRPK13.15431285
5NME23.07053104
6TESK22.92098186
7EIF2AK12.85033144
8IRAK32.78922663
9MAPKAPK32.34692459
10SMG12.33402673
11IRAK42.27386146
12IRAK22.22670826
13CASK2.08672963
14VRK12.00766401
15MAP3K22.00589412
16WEE12.00585643
17STK241.94767760
18IRAK11.93610500
19EEF2K1.88113019
20PLK41.81587876
21ZAK1.77836777
22MKNK21.77389694
23BLK1.75091680
24NLK1.75076814
25MAP3K31.71644946
26PIM21.63769640
27DYRK31.58724057
28CSK1.58644613
29PBK1.37772574
30MKNK11.35571073
31NME11.33687449
32PTK2B1.31278446
33MST41.29721350
34MST1R1.26740039
35NEK61.22385407
36LRRK21.21512227
37EIF2AK21.18241363
38TESK11.17360429
39DYRK21.13192950
40STK101.10612689
41EPHB11.08769707
42AURKA1.05114786
43CDK191.02150768
44BCR1.01798139
45RPS6KA51.00012966
46AURKB0.98535260
47PLK10.98295346
48EPHA20.97710415
49TXK0.97575627
50ICK0.97502127
51EIF2AK30.96851303
52CDK70.96521653
53TRPM70.93629971
54CDC70.92945554
55MAP3K70.92854932
56MARK20.92059182
57PNCK0.88447094
58TTK0.87299828
59TBK10.87125349
60TRIB30.86969701
61KDR0.86699929
62TNIK0.85804496
63TSSK60.83244269
64RIPK40.81722090
65BMPR1B0.79378356
66NEK90.79127767
67ACVR1B0.77230681
68TEC0.76997634
69YES10.74968431
70GRK60.71332806
71LIMK10.68519480
72BRAF0.68173580
73MAP2K20.68075311
74CDK80.67645175
75CHEK20.66500143
76IKBKB0.66398494
77GRK70.65897466
78CLK10.65856041
79DAPK30.64867268
80CAMKK10.64627115
81STK380.63879888
82BRSK20.63197882
83FES0.61129410
84RPS6KA40.60920831
85CSNK2A10.60487985
86IKBKE0.58988550
87ATR0.58696305
88ERBB20.57868895
89RPS6KB20.57835552
90PRPF4B0.57297349
91EPHA30.57061480
92MAP3K110.56578634
93CSNK2A20.55210527
94ADRBK20.54853985
95DYRK1B0.53549330
96TAOK20.53346148
97ERBB30.52466589
98PRKD20.48720441
99PDPK10.48675385
100CAMK2G0.47882792
101CDK30.47619126
102GRK10.47202471
103RIPK10.44998149
104PASK0.44892968
105PRKCQ0.43739395
106BRD40.43681242
107PRKCD0.42750621
108EPHB20.42533226
109ABL20.42213190
110PRKCI0.41613694
111BTK0.40853875
112KIT0.40340922
113MAP3K120.40227263
114LYN0.40223813
115SGK10.38447971
116PKN10.38150176
117MAPK150.37632342
118STK40.37621679
119PAK10.37262049
120TAOK10.36317379
121PLK30.35290425
122PRKAA20.34752668
123HIPK20.34266199
124PIM10.33372228
125MAP3K40.31894944
126PAK40.31558926
127MET0.30773417
128MAP2K40.29735621
129ZAP700.29406874
130PIK3CG0.28261118
131DYRK1A0.27662242
132CHEK10.27076874
133MUSK0.26520208
134LCK0.26373667
135AKT20.25594624
136CDC42BPA0.25518111
137ATM0.25092616
138BMPR20.24354858
139CDK60.24130899
140NUAK10.23262042
141MAP3K60.23248763
142ILK0.22392969
143WNK40.22030557
144PTK60.21898958
145ADRBK10.21799384
146CDK90.21387856
147LATS10.21068310
148CDK20.20989734
149RPS6KA20.20843060
150MARK10.20498344
151PRKACA0.20341780
152ROCK20.18813427
153ROCK10.18546465
154PRKD30.17838935
155PRKCA0.17386499
156MAPKAPK50.17098032
157FGFR30.16507746
158ABL10.15985746
159ARAF0.15885383
160MAP2K70.14773295
161LMTK20.14733886
162SRC0.13385495
163FYN0.12559505
164INSRR0.12151864
165STK38L0.12150637
166OXSR10.11355357
167FER0.10955432
168PDK10.09363161
169MAP3K80.09077841
170STK390.08597339
171EGFR0.07073688

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.69294223
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.85922526
3Phenylalanine metabolism_Homo sapiens_hsa003605.16640681
4Histidine metabolism_Homo sapiens_hsa003404.74364577
5Chemical carcinogenesis_Homo sapiens_hsa052044.66803663
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.37180540
7Tyrosine metabolism_Homo sapiens_hsa003503.94881810
8RNA polymerase_Homo sapiens_hsa030203.82999933
9Proteasome_Homo sapiens_hsa030503.47917329
10DNA replication_Homo sapiens_hsa030303.32742218
11Spliceosome_Homo sapiens_hsa030403.03058236
12beta-Alanine metabolism_Homo sapiens_hsa004103.00378364
13Mismatch repair_Homo sapiens_hsa034302.78819367
14Homologous recombination_Homo sapiens_hsa034402.72835706
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.44835120
16Oxidative phosphorylation_Homo sapiens_hsa001902.44474633
17Nucleotide excision repair_Homo sapiens_hsa034202.42667876
18Pyrimidine metabolism_Homo sapiens_hsa002402.42370770
19Fanconi anemia pathway_Homo sapiens_hsa034602.42135475
20Caffeine metabolism_Homo sapiens_hsa002322.35105289
21Protein export_Homo sapiens_hsa030602.25898860
22Basal transcription factors_Homo sapiens_hsa030222.20712315
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.17334112
24Parkinsons disease_Homo sapiens_hsa050122.05421593
25Base excision repair_Homo sapiens_hsa034102.02453537
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.01405628
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.88023895
28Huntingtons disease_Homo sapiens_hsa050161.81322967
29RNA transport_Homo sapiens_hsa030131.74112592
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.73043477
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.71897934
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.68856503
33One carbon pool by folate_Homo sapiens_hsa006701.42033639
34Tight junction_Homo sapiens_hsa045301.40513269
35Systemic lupus erythematosus_Homo sapiens_hsa053221.39329010
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.38220145
37Alzheimers disease_Homo sapiens_hsa050101.37228499
38RNA degradation_Homo sapiens_hsa030181.35593827
39Non-homologous end-joining_Homo sapiens_hsa034501.30844733
40Purine metabolism_Homo sapiens_hsa002301.30740388
41Cell cycle_Homo sapiens_hsa041101.29287123
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25045614
43Primary immunodeficiency_Homo sapiens_hsa053401.21556274
44Fatty acid degradation_Homo sapiens_hsa000711.21546148
45ABC transporters_Homo sapiens_hsa020101.20951273
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14758488
47Peroxisome_Homo sapiens_hsa041461.11274828
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09696685
49p53 signaling pathway_Homo sapiens_hsa041151.07924630
50Circadian rhythm_Homo sapiens_hsa047101.07229083
51Sphingolipid metabolism_Homo sapiens_hsa006001.06058776
52Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03121452
53Epstein-Barr virus infection_Homo sapiens_hsa051691.01328507
54Arachidonic acid metabolism_Homo sapiens_hsa005901.00843411
55Sulfur relay system_Homo sapiens_hsa041221.00656916
56Salivary secretion_Homo sapiens_hsa049700.98986829
57mRNA surveillance pathway_Homo sapiens_hsa030150.92466889
58Folate biosynthesis_Homo sapiens_hsa007900.92405088
59Graft-versus-host disease_Homo sapiens_hsa053320.87721348
60Starch and sucrose metabolism_Homo sapiens_hsa005000.85628739
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.84857522
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81309232
63Phototransduction_Homo sapiens_hsa047440.81027894
64Herpes simplex infection_Homo sapiens_hsa051680.80826944
65Other glycan degradation_Homo sapiens_hsa005110.79758951
66Antigen processing and presentation_Homo sapiens_hsa046120.76477604
67Hepatitis C_Homo sapiens_hsa051600.73075462
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.70657749
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70624680
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.70321817
71Taste transduction_Homo sapiens_hsa047420.70230759
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69786796
73Allograft rejection_Homo sapiens_hsa053300.69582424
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.68065992
75Autoimmune thyroid disease_Homo sapiens_hsa053200.67925554
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67132127
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.65298212
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63479111
79Alcoholism_Homo sapiens_hsa050340.61775063
80Basal cell carcinoma_Homo sapiens_hsa052170.61453239
81Choline metabolism in cancer_Homo sapiens_hsa052310.60818381
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59223334
83Hematopoietic cell lineage_Homo sapiens_hsa046400.58326391
84Linoleic acid metabolism_Homo sapiens_hsa005910.57013234
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.56805666
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55580762
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55514873
88Measles_Homo sapiens_hsa051620.54999118
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54313303
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53225607
91Glutathione metabolism_Homo sapiens_hsa004800.52427055
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51693175
93Adherens junction_Homo sapiens_hsa045200.51455983
94Asthma_Homo sapiens_hsa053100.49322579
95Cardiac muscle contraction_Homo sapiens_hsa042600.48773783
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45586912
97Olfactory transduction_Homo sapiens_hsa047400.43530617
98Collecting duct acid secretion_Homo sapiens_hsa049660.42989613
99Ether lipid metabolism_Homo sapiens_hsa005650.42899342
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.42895869
101PPAR signaling pathway_Homo sapiens_hsa033200.42737496
102Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40624491
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39985288
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39555530
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39547039
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38060640
107HTLV-I infection_Homo sapiens_hsa051660.37851874
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37386007
109Complement and coagulation cascades_Homo sapiens_hsa046100.37197276
110Vitamin digestion and absorption_Homo sapiens_hsa049770.37109308
111Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37037947
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35785675
113Metabolic pathways_Homo sapiens_hsa011000.35661382
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33595781
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33510088
116Notch signaling pathway_Homo sapiens_hsa043300.33091876
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.33060812
118Lysosome_Homo sapiens_hsa041420.32434639
119Viral carcinogenesis_Homo sapiens_hsa052030.32116337
120Amoebiasis_Homo sapiens_hsa051460.31301776
121Hippo signaling pathway_Homo sapiens_hsa043900.31075022
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30062296
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29091018
124Cocaine addiction_Homo sapiens_hsa050300.28968411
125Arginine and proline metabolism_Homo sapiens_hsa003300.28745270
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.28065169
127Nicotine addiction_Homo sapiens_hsa050330.27861716
128Thyroid cancer_Homo sapiens_hsa052160.26544057
129Wnt signaling pathway_Homo sapiens_hsa043100.26214783
130cAMP signaling pathway_Homo sapiens_hsa040240.26189674
131T cell receptor signaling pathway_Homo sapiens_hsa046600.25733353
132Fructose and mannose metabolism_Homo sapiens_hsa000510.24885259
133Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24342193
134Apoptosis_Homo sapiens_hsa042100.23744009
135Malaria_Homo sapiens_hsa051440.23693928
136Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22425522
137Insulin resistance_Homo sapiens_hsa049310.20872425
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.20844488
139Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20789483
140Rheumatoid arthritis_Homo sapiens_hsa053230.19926410
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.18487682
142Calcium signaling pathway_Homo sapiens_hsa040200.18466131
143Bladder cancer_Homo sapiens_hsa052190.18393550
144Retinol metabolism_Homo sapiens_hsa008300.18249932
145Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.17645587
146Endocytosis_Homo sapiens_hsa041440.17449947
147Fatty acid biosynthesis_Homo sapiens_hsa000610.17379271
148Hedgehog signaling pathway_Homo sapiens_hsa043400.17377762
149Phosphatidylinositol signaling system_Homo sapiens_hsa040700.17007967
150Maturity onset diabetes of the young_Homo sapiens_hsa049500.16785304
151Melanoma_Homo sapiens_hsa052180.16377579
152Pertussis_Homo sapiens_hsa051330.16274326
153Type I diabetes mellitus_Homo sapiens_hsa049400.15186188
154Hepatitis B_Homo sapiens_hsa051610.14792685
155Pentose phosphate pathway_Homo sapiens_hsa000300.14630506
156Glycerolipid metabolism_Homo sapiens_hsa005610.13234237
157Bile secretion_Homo sapiens_hsa049760.13137758
158Pyruvate metabolism_Homo sapiens_hsa006200.13115668
159Pathways in cancer_Homo sapiens_hsa052000.12573820
160Regulation of autophagy_Homo sapiens_hsa041400.12087491
161Influenza A_Homo sapiens_hsa051640.11361448
162Shigellosis_Homo sapiens_hsa051310.11288247
163Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.11253501
164Leishmaniasis_Homo sapiens_hsa051400.11089234
165Serotonergic synapse_Homo sapiens_hsa047260.10064708
166Amphetamine addiction_Homo sapiens_hsa050310.09638279
167Arginine biosynthesis_Homo sapiens_hsa002200.08691690
168Melanogenesis_Homo sapiens_hsa049160.07913038
169Pancreatic secretion_Homo sapiens_hsa049720.04645668
170Prostate cancer_Homo sapiens_hsa052150.03967690

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