WDR19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the WD (tryptophan-aspartic acid) repeat family, which is a large family of structurally-related proteins known to participate in a wide range of cellular processes. Each WD repeat typically contains about 40 amino acids that are usually bracketed by glycine-histidine and tryptophan-aspartic acid (WD) dipeptides. This protein contains six WD repeats, three transmembrane domains, and a clathrin heavy-chain repeat. Mutations in this gene have been described in individuals with a wide range of disorders affecting function of the cilium. These disorders are known as ciliopathies, and include Jeune syndrome, Sensenbrenner syndromes, Senior-Loken syndrome, combined or isolated nephronophthisis (NPHP), and retinitis pigmentosa (RP). Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)6.65903898
2cilium movement (GO:0003341)6.41508041
3axonemal dynein complex assembly (GO:0070286)5.93636280
4epithelial cilium movement (GO:0003351)5.28892068
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.93159790
6axoneme assembly (GO:0035082)4.91084825
7ventricular system development (GO:0021591)4.67195095
8left/right axis specification (GO:0070986)4.14449736
9protein localization to cilium (GO:0061512)3.90995605
10motile cilium assembly (GO:0044458)3.87551195
11* intraciliary transport (GO:0042073)3.81716039
12pyrimidine nucleobase catabolic process (GO:0006208)3.70580132
13* cilium organization (GO:0044782)3.63326721
14* cilium assembly (GO:0042384)3.54364108
15regulation of short-term neuronal synaptic plasticity (GO:0048172)3.41763388
16cerebellar Purkinje cell differentiation (GO:0021702)3.36120355
17regulation of microtubule-based movement (GO:0060632)3.35144081
18cilium morphogenesis (GO:0060271)3.28938432
19righting reflex (GO:0060013)3.26149534
20neuron cell-cell adhesion (GO:0007158)3.25192600
21protein localization to synapse (GO:0035418)3.14611710
22axon ensheathment in central nervous system (GO:0032291)3.13325315
23central nervous system myelination (GO:0022010)3.13325315
24neural tube formation (GO:0001841)3.10187826
25ionotropic glutamate receptor signaling pathway (GO:0035235)3.10105762
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.05910310
27synaptic transmission, glutamatergic (GO:0035249)3.04490600
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.03607084
29regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.00388619
30retinal ganglion cell axon guidance (GO:0031290)2.99846319
31nonmotile primary cilium assembly (GO:0035058)2.99018926
32synaptic vesicle docking involved in exocytosis (GO:0016081)2.98613702
33protein polyglutamylation (GO:0018095)2.98047048
34vocalization behavior (GO:0071625)2.97833633
35negative regulation of oligodendrocyte differentiation (GO:0048715)2.97527427
36limb bud formation (GO:0060174)2.96712848
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.93208446
38* cellular component assembly involved in morphogenesis (GO:0010927)2.93011546
39axonal fasciculation (GO:0007413)2.89561240
40microtubule bundle formation (GO:0001578)2.88285448
41regulation of cilium movement (GO:0003352)2.87029423
42nucleobase catabolic process (GO:0046113)2.86873782
43central nervous system neuron axonogenesis (GO:0021955)2.80610444
44auditory behavior (GO:0031223)2.80357063
45cerebral cortex radially oriented cell migration (GO:0021799)2.80203031
46regulation of glutamate receptor signaling pathway (GO:1900449)2.79992488
47positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.79026888
48glutamate receptor signaling pathway (GO:0007215)2.78998610
49locomotory exploration behavior (GO:0035641)2.78040810
50centriole replication (GO:0007099)2.76495671
51lateral sprouting from an epithelium (GO:0060601)2.76130437
52eye photoreceptor cell differentiation (GO:0001754)2.75398171
53photoreceptor cell differentiation (GO:0046530)2.75398171
54sperm motility (GO:0030317)2.71238858
55determination of left/right symmetry (GO:0007368)2.70787688
56brain morphogenesis (GO:0048854)2.68245947
57acrosome reaction (GO:0007340)2.68130056
58* microtubule-based movement (GO:0007018)2.66323107
59determination of bilateral symmetry (GO:0009855)2.66284022
60synaptic vesicle exocytosis (GO:0016079)2.66100583
61neuron recognition (GO:0008038)2.65822143
62microtubule severing (GO:0051013)2.65619995
63cerebral cortex neuron differentiation (GO:0021895)2.62981566
64regulation of collateral sprouting (GO:0048670)2.62775302
65postsynaptic membrane organization (GO:0001941)2.62241446
66regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.61633098
67G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.61533682
68transmission of nerve impulse (GO:0019226)2.61272397
69olfactory bulb development (GO:0021772)2.61254989
70membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.60345492
71specification of symmetry (GO:0009799)2.59323988
72negative regulation of astrocyte differentiation (GO:0048712)2.59294777
73neuron-neuron synaptic transmission (GO:0007270)2.58968847
74piRNA metabolic process (GO:0034587)2.58353058
75dendrite morphogenesis (GO:0048813)2.57111627
76negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.56484145
77regulation of synaptic vesicle exocytosis (GO:2000300)2.55979208
78response to auditory stimulus (GO:0010996)2.55686767
79calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.54995398
80membrane depolarization during action potential (GO:0086010)2.54942743
81presynaptic membrane assembly (GO:0097105)2.54194915
82regulation of growth hormone secretion (GO:0060123)2.54062309
83innervation (GO:0060384)2.53696548
84retinal rod cell development (GO:0046548)2.53673062
85short-term memory (GO:0007614)2.52775539
86* smoothened signaling pathway (GO:0007224)2.52339469
87photoreceptor cell maintenance (GO:0045494)2.49895793
88synaptic vesicle maturation (GO:0016188)2.49863310
89central nervous system projection neuron axonogenesis (GO:0021952)2.49553168
90glutamate secretion (GO:0014047)2.48163173
91cell migration in hindbrain (GO:0021535)2.47706652
92centriole assembly (GO:0098534)2.46004686
93neuronal action potential propagation (GO:0019227)2.43426236
94startle response (GO:0001964)2.42825502
95positive regulation of growth hormone secretion (GO:0060124)2.42525171
96apical protein localization (GO:0045176)2.41884736
97mechanosensory behavior (GO:0007638)2.41722339
98glycosphingolipid biosynthetic process (GO:0006688)2.41486459
99neurotransmitter-gated ion channel clustering (GO:0072578)2.39813564
100cerebral cortex cell migration (GO:0021795)2.39424920
101embryonic retina morphogenesis in camera-type eye (GO:0060059)2.38527992
102establishment of nucleus localization (GO:0040023)2.35227479
103regulation of neuronal synaptic plasticity (GO:0048168)2.34676999
104L-amino acid import (GO:0043092)2.34607967
105regulation of neurotransmitter secretion (GO:0046928)2.33334204
106* cell projection assembly (GO:0030031)2.33185515
107calcium ion-dependent exocytosis (GO:0017156)2.32861543
108lateral ventricle development (GO:0021670)2.32539384
109synaptic vesicle endocytosis (GO:0048488)2.31819616
110cyclic nucleotide catabolic process (GO:0009214)2.31760227
111retinal cone cell development (GO:0046549)2.31713304
112cell differentiation in hindbrain (GO:0021533)2.30332037
113detection of calcium ion (GO:0005513)2.30042959
114nucleus localization (GO:0051647)2.29556137
115gamma-aminobutyric acid signaling pathway (GO:0007214)2.29460489
116cerebellum development (GO:0021549)2.29125540
117microtubule depolymerization (GO:0007019)2.28994644
118regulation of synaptic vesicle transport (GO:1902803)2.28979760
119positive regulation of smoothened signaling pathway (GO:0045880)2.28347466
120calcium ion import (GO:0070509)2.28231573
121otic vesicle formation (GO:0030916)2.27618779
122head development (GO:0060322)2.27200532
123mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.27191517
124positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.27191517
125positive regulation of meiosis (GO:0045836)2.27153730
126synapse assembly (GO:0007416)2.27064276
127male meiosis (GO:0007140)2.26913809
128hippocampus development (GO:0021766)2.26905197
129appendage development (GO:0048736)2.26731637
130limb development (GO:0060173)2.26731637
131phosphorelay signal transduction system (GO:0000160)2.25762489
132neuronal stem cell maintenance (GO:0097150)2.25357880
133negative regulation of synaptic transmission, GABAergic (GO:0032229)2.24582597
134membrane hyperpolarization (GO:0060081)2.24094605
135establishment of planar polarity (GO:0001736)2.23838943
136establishment of tissue polarity (GO:0007164)2.23838943
137regulation of smoothened signaling pathway (GO:0008589)2.23252552
138positive regulation of dendritic spine morphogenesis (GO:0061003)2.22983149
139* microtubule-based transport (GO:0010970)2.22672322
140negative regulation of cytosolic calcium ion concentration (GO:0051481)2.20981100
141left/right pattern formation (GO:0060972)2.20844971
142regulation of synaptic transmission, glutamatergic (GO:0051966)2.20664235
143neuromuscular synaptic transmission (GO:0007274)2.20446988
144multicellular organism reproduction (GO:0032504)2.19857480
145establishment of protein localization to Golgi (GO:0072600)2.19673275
146microtubule polymerization or depolymerization (GO:0031109)2.19431592
147ganglion development (GO:0061548)2.19358722
148regulation of non-canonical Wnt signaling pathway (GO:2000050)2.18220875
149cellular potassium ion homeostasis (GO:0030007)2.17612738
150positive regulation of synapse assembly (GO:0051965)2.17541866
151presynaptic membrane organization (GO:0097090)2.17415973
152atrial cardiac muscle cell action potential (GO:0086014)2.16793007
153regulation of oligodendrocyte differentiation (GO:0048713)2.16555164
154regulation of synapse assembly (GO:0051963)2.16366812
155gamma-aminobutyric acid transport (GO:0015812)2.15782243
156cAMP catabolic process (GO:0006198)2.15524368

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.67838490
2GBX2_23144817_ChIP-Seq_PC3_Human3.73532703
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.63944979
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39821619
5VDR_22108803_ChIP-Seq_LS180_Human2.26122771
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.15201333
7ZNF274_21170338_ChIP-Seq_K562_Hela2.12911921
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07667472
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.06866775
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06255455
11DROSHA_22980978_ChIP-Seq_HELA_Human2.02113669
12SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.99356665
13JARID2_20064375_ChIP-Seq_MESCs_Mouse1.95500595
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95286161
15SMAD4_21799915_ChIP-Seq_A2780_Human1.90646910
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90368355
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.90329440
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88387952
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.87195614
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84184115
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.80440307
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80136503
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.80022386
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.78324069
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.78324069
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.78243820
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76705421
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74598364
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73892922
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.72856045
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70833001
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69804209
33P300_19829295_ChIP-Seq_ESCs_Human1.69206980
34AR_21572438_ChIP-Seq_LNCaP_Human1.68896016
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.67772915
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67115356
37* RNF2_27304074_Chip-Seq_NSC_Mouse1.66410543
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.65054665
39REST_21632747_ChIP-Seq_MESCs_Mouse1.64193626
40SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.64091251
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.63951241
42TAF15_26573619_Chip-Seq_HEK293_Human1.61179625
43FUS_26573619_Chip-Seq_HEK293_Human1.60746803
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.58983818
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.58616842
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57953028
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.57596073
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.57555528
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53950044
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52576041
51STAT3_23295773_ChIP-Seq_U87_Human1.51235101
52IGF1R_20145208_ChIP-Seq_DFB_Human1.50197293
53CBP_20019798_ChIP-Seq_JUKART_Human1.49205413
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49205413
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47377978
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47111889
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47068169
58TP53_16413492_ChIP-PET_HCT116_Human1.45097325
59ARNT_22903824_ChIP-Seq_MCF-7_Human1.44255716
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44075453
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.43608851
62ER_23166858_ChIP-Seq_MCF-7_Human1.42896075
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42764637
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41866660
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.40330694
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39060061
67TCF4_23295773_ChIP-Seq_U87_Human1.37685745
68AHR_22903824_ChIP-Seq_MCF-7_Human1.35085468
69E2F1_18555785_Chip-Seq_ESCs_Mouse1.34613149
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34045448
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33204568
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31378576
73* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30814074
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30037466
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28992634
76* TCF4_22108803_ChIP-Seq_LS180_Human1.27865544
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27434494
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27434494
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27115249
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26402164
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26061085
82OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25832702
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25603980
84AR_25329375_ChIP-Seq_VCAP_Human1.23929021
85P53_22387025_ChIP-Seq_ESCs_Mouse1.23043751
86CMYC_18555785_Chip-Seq_ESCs_Mouse1.22872560
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22043632
88IRF1_19129219_ChIP-ChIP_H3396_Human1.21379368
89TP53_18474530_ChIP-ChIP_U2OS_Human1.21351390
90STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.20753955
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19714428
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19657269
93SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19592604
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19294947
95EWS_26573619_Chip-Seq_HEK293_Human1.18466670
96PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18236618
97RUNX2_22187159_ChIP-Seq_PCA_Human1.17954077
98KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17339601
99LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15999019
100* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15988728
101SOX9_26525672_Chip-Seq_HEART_Mouse1.15243989
102STAT3_18555785_Chip-Seq_ESCs_Mouse1.14173597
103FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13521269
104P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13125494
105NFE2_27457419_Chip-Seq_LIVER_Mouse1.12995153
106RARB_27405468_Chip-Seq_BRAIN_Mouse1.12602921
107YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11886119
108P300_18555785_Chip-Seq_ESCs_Mouse1.11074767
109POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10384634
110* AR_19668381_ChIP-Seq_PC3_Human1.10383515
111GATA1_26923725_Chip-Seq_HPCs_Mouse1.10115443
112SMAD3_21741376_ChIP-Seq_ESCs_Human1.08811524
113CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07936085
114EZH2_27294783_Chip-Seq_NPCs_Mouse1.07575897
115SMAD4_21741376_ChIP-Seq_EPCs_Human1.07311365
116SOX2_21211035_ChIP-Seq_LN229_Gbm1.06798397
117EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06742377
118SOX2_18555785_Chip-Seq_ESCs_Mouse1.06325261
119BCAT_22108803_ChIP-Seq_LS180_Human1.06248905
120WT1_19549856_ChIP-ChIP_CCG9911_Human1.06171725
121TAL1_26923725_Chip-Seq_HPCs_Mouse1.05848125
122JUN_21703547_ChIP-Seq_K562_Human1.02004346
123RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00523713
124CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98974729

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.80996444
2MP0000569_abnormal_digit_pigmentation3.42521725
3MP0003880_abnormal_central_pattern2.88063536
4MP0001984_abnormal_olfaction2.43591080
5MP0005646_abnormal_pituitary_gland2.37129364
6MP0003787_abnormal_imprinting2.35629512
7MP0002638_abnormal_pupillary_reflex2.33636311
8MP0003635_abnormal_synaptic_transmissio2.25574100
9MP0000778_abnormal_nervous_system2.24533196
10MP0001968_abnormal_touch/_nociception2.21180855
11MP0009046_muscle_twitch2.09087167
12MP0009745_abnormal_behavioral_response2.02899690
13MP0001188_hyperpigmentation2.02733496
14MP0005551_abnormal_eye_electrophysiolog2.01917023
15MP0002653_abnormal_ependyma_morphology1.98817928
16MP0004270_analgesia1.94689539
17MP0000383_abnormal_hair_follicle1.93790767
18MP0002063_abnormal_learning/memory/cond1.93611807
19MP0001486_abnormal_startle_reflex1.93227505
20MP0005410_abnormal_fertilization1.91911559
21MP0006292_abnormal_olfactory_placode1.88886580
22MP0002734_abnormal_mechanical_nocicepti1.84068198
23MP0003136_yellow_coat_color1.82883140
24MP0002572_abnormal_emotion/affect_behav1.80839771
25MP0002272_abnormal_nervous_system1.77004224
26MP0002064_seizures1.75084926
27MP0002736_abnormal_nociception_after1.73663898
28MP0005623_abnormal_meninges_morphology1.72132472
29MP0000566_synostosis1.68531894
30MP0005171_absent_coat_pigmentation1.67961238
31MP0001502_abnormal_circadian_rhythm1.65885702
32MP0005423_abnormal_somatic_nervous1.61626362
33MP0008877_abnormal_DNA_methylation1.60002491
34MP0005248_abnormal_Harderian_gland1.57668800
35MP0002557_abnormal_social/conspecific_i1.56688914
36MP0003122_maternal_imprinting1.54842657
37MP0005645_abnormal_hypothalamus_physiol1.53820724
38MP0008004_abnormal_stomach_pH1.52765929
39MP0006276_abnormal_autonomic_nervous1.49297855
40MP0002735_abnormal_chemical_nociception1.47309631
41MP0003121_genomic_imprinting1.47025156
42MP0005253_abnormal_eye_physiology1.44928896
43MP0002184_abnormal_innervation1.43112074
44MP0000631_abnormal_neuroendocrine_gland1.42620724
45MP0001440_abnormal_grooming_behavior1.41263401
46MP0006072_abnormal_retinal_apoptosis1.37724506
47MP0002067_abnormal_sensory_capabilities1.35245364
48MP0002882_abnormal_neuron_morphology1.34305881
49MP0003698_abnormal_male_reproductive1.33317020
50MP0005394_taste/olfaction_phenotype1.32974446
51MP0005499_abnormal_olfactory_system1.32974446
52MP0010678_abnormal_skin_adnexa1.32218105
53MP0002282_abnormal_trachea_morphology1.32051087
54MP0001501_abnormal_sleep_pattern1.31820171
55MP0001293_anophthalmia1.29707861
56MP0004885_abnormal_endolymph1.27436521
57MP0004133_heterotaxia1.27098162
58MP0004043_abnormal_pH_regulation1.26431875
59MP0005187_abnormal_penis_morphology1.25346359
60MP0001485_abnormal_pinna_reflex1.24999650
61MP0002928_abnormal_bile_duct1.19840777
62MP0002751_abnormal_autonomic_nervous1.17759497
63MP0002752_abnormal_somatic_nervous1.17511671
64MP0004742_abnormal_vestibular_system1.17312592
65MP0003195_calcinosis1.16150857
66MP0000955_abnormal_spinal_cord1.15990809
67MP0010386_abnormal_urinary_bladder1.13906067
68MP0000427_abnormal_hair_cycle1.13849502
69MP0002938_white_spotting1.12505414
70MP0009780_abnormal_chondrocyte_physiolo1.11024137
71MP0001963_abnormal_hearing_physiology1.09542482
72MP0003755_abnormal_palate_morphology1.09438385
73MP0005503_abnormal_tendon_morphology1.08835033
74MP0000647_abnormal_sebaceous_gland1.08599707
75MP0008789_abnormal_olfactory_epithelium1.07999959
76MP0008569_lethality_at_weaning1.07202696
77MP0002152_abnormal_brain_morphology1.06800133
78MP0003890_abnormal_embryonic-extraembry1.06435081
79MP0000026_abnormal_inner_ear1.06137096
80MP0004811_abnormal_neuron_physiology1.05647776
81MP0002822_catalepsy1.05129405
82MP0002909_abnormal_adrenal_gland1.04561637
83MP0003119_abnormal_digestive_system1.02036073
84MP0010030_abnormal_orbit_morphology1.01340218
85MP0003879_abnormal_hair_cell1.01055118
86MP0001529_abnormal_vocalization1.00688507
87MP0001346_abnormal_lacrimal_gland1.00614596
88MP0000015_abnormal_ear_pigmentation1.00143197
89MP0003942_abnormal_urinary_system0.99769557
90MP0001299_abnormal_eye_distance/0.97088788
91MP0001286_abnormal_eye_development0.96690203
92MP0006054_spinal_hemorrhage0.96562736
93MP0005386_behavior/neurological_phenoty0.96028568
94MP0004924_abnormal_behavior0.96028568
95MP0003861_abnormal_nervous_system0.95837963
96MP0001970_abnormal_pain_threshold0.94890552
97MP0005195_abnormal_posterior_eye0.94612233
98MP0001177_atelectasis0.93806570
99MP0002210_abnormal_sex_determination0.93117478
100MP0003937_abnormal_limbs/digits/tail_de0.92863441
101MP0001929_abnormal_gametogenesis0.92429132
102MP0002177_abnormal_outer_ear0.92189512
103MP0002160_abnormal_reproductive_system0.92090568
104MP0002733_abnormal_thermal_nociception0.91734857
105MP0004142_abnormal_muscle_tone0.87679318
106MP0008995_early_reproductive_senescence0.87413698
107MP0008875_abnormal_xenobiotic_pharmacok0.87392062
108MP0000049_abnormal_middle_ear0.87369305
109MP0002697_abnormal_eye_size0.86976422
110MP0003878_abnormal_ear_physiology0.85776460
111MP0005377_hearing/vestibular/ear_phenot0.85776460
112MP0000534_abnormal_ureter_morphology0.85774478
113MP0002102_abnormal_ear_morphology0.85025765
114MP0001905_abnormal_dopamine_level0.83361655
115MP0004858_abnormal_nervous_system0.81251916
116MP0008057_abnormal_DNA_replication0.81108759
117MP0002084_abnormal_developmental_patter0.80437313
118MP0002116_abnormal_craniofacial_bone0.76918425
119MP0009250_abnormal_appendicular_skeleto0.76661317
120MP0003938_abnormal_ear_development0.76359005
121MP0002066_abnormal_motor_capabilities/c0.75237113
122MP0003634_abnormal_glial_cell0.75154607
123MP0002229_neurodegeneration0.75069587
124MP0005391_vision/eye_phenotype0.73601354
125MP0002233_abnormal_nose_morphology0.73236946
126MP0001324_abnormal_eye_pigmentation0.72419378

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.01104332
2Abnormal respiratory motile cilium physiology (HP:0012261)6.46950632
3Abnormal ciliary motility (HP:0012262)5.83277925
4Absent/shortened dynein arms (HP:0200106)5.71082475
5Dynein arm defect of respiratory motile cilia (HP:0012255)5.71082475
6Rhinitis (HP:0012384)5.20166163
7Abnormal respiratory epithelium morphology (HP:0012253)5.00366717
8Abnormal respiratory motile cilium morphology (HP:0005938)5.00366717
9True hermaphroditism (HP:0010459)4.01788675
10Chronic bronchitis (HP:0004469)3.91332885
11Pancreatic fibrosis (HP:0100732)3.63203160
12Nephronophthisis (HP:0000090)3.50659281
13Medial flaring of the eyebrow (HP:0010747)3.32039578
14Abnormality of midbrain morphology (HP:0002418)3.18208373
15Molar tooth sign on MRI (HP:0002419)3.18208373
16Febrile seizures (HP:0002373)3.13992106
17Chronic hepatic failure (HP:0100626)3.05243226
18Focal motor seizures (HP:0011153)3.05187727
19Gait imbalance (HP:0002141)2.97018974
20Occipital encephalocele (HP:0002085)2.96862007
21Epileptic encephalopathy (HP:0200134)2.90068123
22Cystic liver disease (HP:0006706)2.86965816
23Congenital primary aphakia (HP:0007707)2.82577591
24Nephrogenic diabetes insipidus (HP:0009806)2.77142272
25Pancreatic cysts (HP:0001737)2.74520520
26Abnormality of the renal medulla (HP:0100957)2.71753224
27Aplasia/Hypoplasia of the tongue (HP:0010295)2.60398088
28* Postaxial foot polydactyly (HP:0001830)2.56919383
29Genital tract atresia (HP:0001827)2.51678477
30Bronchiectasis (HP:0002110)2.49677332
31Vaginal atresia (HP:0000148)2.45098790
32Bile duct proliferation (HP:0001408)2.42453704
33Abnormal biliary tract physiology (HP:0012439)2.42453704
34Anencephaly (HP:0002323)2.40338295
35Congenital hepatic fibrosis (HP:0002612)2.34588083
36Median cleft lip (HP:0000161)2.32882604
37Supernumerary spleens (HP:0009799)2.24764582
38Congenital stationary night blindness (HP:0007642)2.23262439
39Progressive cerebellar ataxia (HP:0002073)2.20914512
40* Postaxial hand polydactyly (HP:0001162)2.20480485
41Atonic seizures (HP:0010819)2.20473690
42Preaxial hand polydactyly (HP:0001177)2.18823253
43Broad foot (HP:0001769)2.15257836
44Bell-shaped thorax (HP:0001591)2.13327769
45Gaze-evoked nystagmus (HP:0000640)2.13106905
46Abnormality of macular pigmentation (HP:0008002)2.07581522
47Focal seizures (HP:0007359)2.06896921
48Male pseudohermaphroditism (HP:0000037)2.06557122
49Poor coordination (HP:0002370)2.05278335
50Tubular atrophy (HP:0000092)2.05021124
51Abnormal hair whorl (HP:0010721)2.01087711
52Abnormality of the renal cortex (HP:0011035)1.98684739
53Aplasia/Hypoplasia of the lens (HP:0008063)1.97327524
54Decreased testicular size (HP:0008734)1.96454326
55Genetic anticipation (HP:0003743)1.95525593
56Infertility (HP:0000789)1.89940632
57Bony spicule pigmentary retinopathy (HP:0007737)1.89936376
58Fibular hypoplasia (HP:0003038)1.88970485
59Protruding tongue (HP:0010808)1.87880011
60Intestinal atresia (HP:0011100)1.86871553
61Central scotoma (HP:0000603)1.86251745
62Nasal polyposis (HP:0100582)1.82361314
63Drooling (HP:0002307)1.82229708
64Abnormal drinking behavior (HP:0030082)1.82068142
65Polydipsia (HP:0001959)1.82068142
66Dyschromatopsia (HP:0007641)1.79590096
67Facial cleft (HP:0002006)1.77802821
68Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.77331735
69Degeneration of the lateral corticospinal tracts (HP:0002314)1.77331735
70Prominent nasal bridge (HP:0000426)1.77158423
71Specific learning disability (HP:0001328)1.76941951
72Micropenis (HP:0000054)1.76640600
73Anophthalmia (HP:0000528)1.76240236
74Intellectual disability, moderate (HP:0002342)1.73821253
75* Tubulointerstitial abnormality (HP:0001969)1.71637600
76Sclerocornea (HP:0000647)1.70152267
77Highly arched eyebrow (HP:0002553)1.68267686
78Chronic sinusitis (HP:0011109)1.67308869
79Renal dysplasia (HP:0000110)1.66663893
80Furrowed tongue (HP:0000221)1.66509670
81Aplasia/Hypoplasia of the tibia (HP:0005772)1.66493905
82Omphalocele (HP:0001539)1.65722164
83Myokymia (HP:0002411)1.64804652
84Absent speech (HP:0001344)1.64340791
85Decreased central vision (HP:0007663)1.64073729
86Bronchitis (HP:0012387)1.63452394
87* Abnormality of dentin (HP:0010299)1.63205929
88Oculomotor apraxia (HP:0000657)1.63029499
89Septo-optic dysplasia (HP:0100842)1.62183192
90Multicystic kidney dysplasia (HP:0000003)1.62152267
91Narrow forehead (HP:0000341)1.61864180
92Oligodactyly (hands) (HP:0001180)1.61357783
93* Tubulointerstitial nephritis (HP:0001970)1.60486088
94Aganglionic megacolon (HP:0002251)1.59737742
95* Stage 5 chronic kidney disease (HP:0003774)1.59210641
96Chromosomal breakage induced by crosslinking agents (HP:0003221)1.59141585
97Hyperventilation (HP:0002883)1.58460182
98Ectopic anus (HP:0004397)1.58401877
99Excessive salivation (HP:0003781)1.57873764
100Bifid tongue (HP:0010297)1.56788301
101Absent frontal sinuses (HP:0002688)1.56428965
102Mesomelia (HP:0003027)1.54286698
103Abnormality of the labia minora (HP:0012880)1.53706010
104* Short foot (HP:0001773)1.53348773
105Hepatoblastoma (HP:0002884)1.53205605
106Abnormal rod and cone electroretinograms (HP:0008323)1.53072869
107Chorioretinal coloboma (HP:0000567)1.52532235
108Polyphagia (HP:0002591)1.51916000
109Hemiparesis (HP:0001269)1.51780047
110* Renal hypoplasia (HP:0000089)1.51088361
111Volvulus (HP:0002580)1.50743379
112Abnormality of the corticospinal tract (HP:0002492)1.50070346
113Action tremor (HP:0002345)1.48756987
114Recurrent sinusitis (HP:0011108)1.48740591
115Urinary bladder sphincter dysfunction (HP:0002839)1.48449792
116Optic nerve coloboma (HP:0000588)1.48397274
117Gonadotropin excess (HP:0000837)1.48228655
118Dandy-Walker malformation (HP:0001305)1.46810315
119Gastrointestinal atresia (HP:0002589)1.46596911
120Widely spaced teeth (HP:0000687)1.45914695
121Retinal dysplasia (HP:0007973)1.45877761
122Papillary thyroid carcinoma (HP:0002895)1.44979664
123Dysdiadochokinesis (HP:0002075)1.44537055
124Congenital sensorineural hearing impairment (HP:0008527)1.43418098
125Astigmatism (HP:0000483)1.42446279
126Cupped ear (HP:0000378)1.42025085
127Midline defect of the nose (HP:0004122)1.41695644
128Chromsome breakage (HP:0040012)1.41085574
129Labial hypoplasia (HP:0000066)1.40762060
130Abnormality of the nasal septum (HP:0000419)1.40209424
131Lower limb muscle weakness (HP:0007340)1.40172026
132Broad-based gait (HP:0002136)1.39677353

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B5.47488161
2FRK3.41965025
3NTRK33.25381424
4CASK2.81061210
5TNIK2.45838115
6MAP4K22.39701738
7MAPK152.37433681
8EPHA42.35732633
9MAP2K72.11959297
10MAP3K41.99652075
11EPHA31.97757932
12PNCK1.96161920
13MARK11.90308206
14TRIM281.90254609
15SGK21.87904366
16MAPK131.85441974
17PRKD31.80521899
18CAMK1G1.75759602
19SGK4941.73718290
20SGK2231.73718290
21NTRK21.73399239
22CAMK1D1.65988967
23NEK61.65632665
24ERBB31.56174839
25SIK31.50381522
26ICK1.43307169
27PLK21.40545823
28BMPR21.38329349
29BRSK21.35980668
30MKNK11.35135058
31CSNK1G21.33686916
32GRK11.33652380
33SGK31.31523132
34AKT31.24025157
35CSNK1G11.23268665
36BCR1.21112058
37NUAK11.19559622
38CDK191.12821940
39MINK11.12811141
40PDK21.08316229
41PRKCG1.04240279
42CSNK1G31.02615946
43PTK2B1.02545554
44BRD41.01357992
45EPHB21.00974797
46WNK30.99939389
47MAP3K130.99327796
48DAPK20.98229580
49LATS10.98026493
50DYRK20.97937295
51CDC42BPA0.97752670
52WNK10.97747308
53CDK30.96932064
54MAP3K90.95942125
55PAK60.93424528
56STK380.93398317
57ACVR1B0.92867884
58MAP2K40.90815625
59PRKCE0.90609979
60STK390.90153995
61WEE10.88594898
62OXSR10.87558004
63NLK0.87416332
64BMPR1B0.87231209
65YES10.83587926
66CDK80.79231430
67PHKG10.79029119
68PHKG20.79029119
69CDK50.77781852
70DYRK1A0.77752986
71CAMKK10.76510648
72STK38L0.75089376
73SGK10.73488553
74IRAK20.69934689
75MAP3K70.68490092
76CCNB10.66613935
77MKNK20.66281477
78RPS6KA20.66138992
79DYRK1B0.65572205
80MAP3K140.65199237
81FER0.64733788
82TSSK60.64140425
83MAPK70.61122626
84TNK20.59858551
85CAMK2A0.59331520
86RPS6KB10.58984019
87PASK0.58603374
88ERBB20.57821529
89PAK30.57157464
90CDK120.56725209
91CSNK1D0.55536120
92TGFBR10.54900647
93TYRO30.54480078
94INSRR0.54348901
95DYRK30.53456920
96FGFR20.52666834
97MARK20.52324988
98EIF2AK30.51607655
99UHMK10.51525802
100DDR20.49388160
101DMPK0.49103476
102PINK10.48756690
103KSR10.48524371
104STK240.47785839
105TAOK20.47604565
106MAPK100.47561251
107PLK30.47402085
108IRAK10.47017827
109STK30.46877417
110CAMK10.46588841
111WNK40.45870586
112SIK20.45686876
113ADRBK20.45378969
114PRKAA10.45164765
115MST40.44845973
116ATM0.43833093
117PIK3CA0.43731142
118FGFR10.43403258
119CSNK1E0.42087709
120PKN10.42003577
121PRKG10.40270695
122GSK3B0.40212079
123STK110.39025203
124CSNK1A1L0.38538860
125PLK10.37643900
126PRKDC0.37417078
127CAMK2B0.37376564
128NEK90.37288431
129PDK40.37286593
130PDK30.37286593
131CAMK40.36157308
132MAP3K20.35730819
133PRKCZ0.35485186
134CLK10.35060836
135CAMKK20.34703174
136ROCK10.34662553
137CSNK1A10.34166130
138FES0.34075109
139MAPK80.33528786
140RIPK40.32769693
141LATS20.32251700

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.16319196
2Olfactory transduction_Homo sapiens_hsa047402.74434767
3Phototransduction_Homo sapiens_hsa047442.72006157
4Synaptic vesicle cycle_Homo sapiens_hsa047212.40789699
5Circadian entrainment_Homo sapiens_hsa047132.34170535
6Morphine addiction_Homo sapiens_hsa050322.31653016
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26695965
8Glutamatergic synapse_Homo sapiens_hsa047242.18176550
9Butanoate metabolism_Homo sapiens_hsa006502.15579179
10GABAergic synapse_Homo sapiens_hsa047272.13327905
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.13255787
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.90318077
13Propanoate metabolism_Homo sapiens_hsa006401.81894546
14beta-Alanine metabolism_Homo sapiens_hsa004101.77016506
15Taste transduction_Homo sapiens_hsa047421.67076204
16Amphetamine addiction_Homo sapiens_hsa050311.64994335
17Serotonergic synapse_Homo sapiens_hsa047261.64851945
18Insulin secretion_Homo sapiens_hsa049111.64254684
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.63993268
20Cholinergic synapse_Homo sapiens_hsa047251.59308437
21Long-term potentiation_Homo sapiens_hsa047201.55720934
22Dopaminergic synapse_Homo sapiens_hsa047281.53733454
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.51999724
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46462379
25Chemical carcinogenesis_Homo sapiens_hsa052041.45416865
26Axon guidance_Homo sapiens_hsa043601.40180046
27ABC transporters_Homo sapiens_hsa020101.38811924
28Salivary secretion_Homo sapiens_hsa049701.38702556
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34869430
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34046696
31Calcium signaling pathway_Homo sapiens_hsa040201.33279186
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.30065420
33Collecting duct acid secretion_Homo sapiens_hsa049661.28768776
34Cocaine addiction_Homo sapiens_hsa050301.26224826
35Basal transcription factors_Homo sapiens_hsa030221.24626092
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23452138
37Renin secretion_Homo sapiens_hsa049241.23284014
38cAMP signaling pathway_Homo sapiens_hsa040241.22799328
39Steroid biosynthesis_Homo sapiens_hsa001001.22536780
40TGF-beta signaling pathway_Homo sapiens_hsa043501.21811296
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21574612
42Histidine metabolism_Homo sapiens_hsa003401.19918370
43Oxytocin signaling pathway_Homo sapiens_hsa049211.19714963
44Gastric acid secretion_Homo sapiens_hsa049711.19278427
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.19248876
46Circadian rhythm_Homo sapiens_hsa047101.18797376
47Wnt signaling pathway_Homo sapiens_hsa043101.15539527
48Retinol metabolism_Homo sapiens_hsa008301.14162043
49Type II diabetes mellitus_Homo sapiens_hsa049301.13584226
50Ovarian steroidogenesis_Homo sapiens_hsa049131.13213783
51Long-term depression_Homo sapiens_hsa047301.13021777
52GnRH signaling pathway_Homo sapiens_hsa049121.12543540
53Lysine degradation_Homo sapiens_hsa003101.12503271
54Melanogenesis_Homo sapiens_hsa049161.11332447
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08796718
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06862998
57Linoleic acid metabolism_Homo sapiens_hsa005911.02466918
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02242371
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01507713
60cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01231552
61ErbB signaling pathway_Homo sapiens_hsa040120.99947193
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99054365
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97761961
64Regulation of autophagy_Homo sapiens_hsa041400.96869034
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96375403
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95111350
67Basal cell carcinoma_Homo sapiens_hsa052170.94469856
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.94315834
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93446317
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93159041
71Estrogen signaling pathway_Homo sapiens_hsa049150.92736186
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91344880
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91064159
74Fatty acid degradation_Homo sapiens_hsa000710.90357782
75Vibrio cholerae infection_Homo sapiens_hsa051100.90024403
76MAPK signaling pathway_Homo sapiens_hsa040100.89751045
77Hedgehog signaling pathway_Homo sapiens_hsa043400.89714199
78Caffeine metabolism_Homo sapiens_hsa002320.89543290
79Inositol phosphate metabolism_Homo sapiens_hsa005620.89100170
80Gap junction_Homo sapiens_hsa045400.88998208
81Fatty acid metabolism_Homo sapiens_hsa012120.87768827
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87415072
83Non-homologous end-joining_Homo sapiens_hsa034500.85817330
84Nitrogen metabolism_Homo sapiens_hsa009100.84461345
85Dilated cardiomyopathy_Homo sapiens_hsa054140.83672792
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80057566
87Protein export_Homo sapiens_hsa030600.79871329
88Hippo signaling pathway_Homo sapiens_hsa043900.78951888
89Ras signaling pathway_Homo sapiens_hsa040140.78926552
90Peroxisome_Homo sapiens_hsa041460.75339447
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.73121398
92Fanconi anemia pathway_Homo sapiens_hsa034600.72995269
93Tryptophan metabolism_Homo sapiens_hsa003800.72194067
94Dorso-ventral axis formation_Homo sapiens_hsa043200.72179682
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70597188
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69728219
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69304156
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68853857
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67982214
100Tyrosine metabolism_Homo sapiens_hsa003500.67401488
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67231070
102Ether lipid metabolism_Homo sapiens_hsa005650.65998386
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.65362936
104Huntingtons disease_Homo sapiens_hsa050160.64223765
105Phagosome_Homo sapiens_hsa041450.63883718
106Mineral absorption_Homo sapiens_hsa049780.63724577
107Rap1 signaling pathway_Homo sapiens_hsa040150.62992839
108Oocyte meiosis_Homo sapiens_hsa041140.62926872
109Glioma_Homo sapiens_hsa052140.62844362
110Rheumatoid arthritis_Homo sapiens_hsa053230.62300707
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61559208
112Choline metabolism in cancer_Homo sapiens_hsa052310.61545926
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60809639
114Alcoholism_Homo sapiens_hsa050340.58549588
115Thyroid hormone synthesis_Homo sapiens_hsa049180.58373854
116Phenylalanine metabolism_Homo sapiens_hsa003600.56756951
117Endometrial cancer_Homo sapiens_hsa052130.56188411
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55869242
119Colorectal cancer_Homo sapiens_hsa052100.54604616
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53856754
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53754015
122Selenocompound metabolism_Homo sapiens_hsa004500.52519058
123Sphingolipid metabolism_Homo sapiens_hsa006000.50830569
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.50810766
125Tight junction_Homo sapiens_hsa045300.50673005
126Type I diabetes mellitus_Homo sapiens_hsa049400.50072260
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49153059
128RNA degradation_Homo sapiens_hsa030180.49086108
129Adherens junction_Homo sapiens_hsa045200.48523942
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48268787
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47741333
132Melanoma_Homo sapiens_hsa052180.47670538
133Glucagon signaling pathway_Homo sapiens_hsa049220.47110371
134ECM-receptor interaction_Homo sapiens_hsa045120.47071045
135Notch signaling pathway_Homo sapiens_hsa043300.46538215
136Pathways in cancer_Homo sapiens_hsa052000.45895239
137mRNA surveillance pathway_Homo sapiens_hsa030150.45885596
138Chemokine signaling pathway_Homo sapiens_hsa040620.45747197
139Prostate cancer_Homo sapiens_hsa052150.45306765
140Maturity onset diabetes of the young_Homo sapiens_hsa049500.43595792
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.39918980

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