WDR11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to ethanol (GO:0071361)4.78430783
2macroautophagy (GO:0016236)4.49475745
3phospholipid homeostasis (GO:0055091)4.31696458
4alpha-linolenic acid metabolic process (GO:0036109)4.30544511
5COPI coating of Golgi vesicle (GO:0048205)4.12115114
6Golgi transport vesicle coating (GO:0048200)4.12115114
7urea cycle (GO:0000050)3.98241778
8urea metabolic process (GO:0019627)3.98241778
9dicarboxylic acid biosynthetic process (GO:0043650)3.95278524
10L-phenylalanine catabolic process (GO:0006559)3.91175560
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.91175560
12negative regulation of neurotransmitter secretion (GO:0046929)3.82468707
13lysine catabolic process (GO:0006554)3.80205841
14lysine metabolic process (GO:0006553)3.80205841
15L-phenylalanine metabolic process (GO:0006558)3.76650825
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.76650825
17positive regulation of gamma-delta T cell activation (GO:0046645)3.69848695
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.67417380
19peptide catabolic process (GO:0043171)3.67183013
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.63744417
21regulation of B cell receptor signaling pathway (GO:0050855)3.62694061
22regulation of fatty acid beta-oxidation (GO:0031998)3.53867935
23histone H3-K36 demethylation (GO:0070544)3.45342583
24nuclear pore complex assembly (GO:0051292)3.44279503
25regulation of cholesterol homeostasis (GO:2000188)3.43887925
26negative regulation of interleukin-12 production (GO:0032695)3.42065379
27nitrogen cycle metabolic process (GO:0071941)3.38626683
28peptidyl-glutamic acid carboxylation (GO:0017187)3.34013128
29protein carboxylation (GO:0018214)3.34013128
30phospholipid translocation (GO:0045332)3.28647490
31lipid translocation (GO:0034204)3.28647490
32retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.25627936
33B cell receptor signaling pathway (GO:0050853)3.24402997
34homocysteine metabolic process (GO:0050667)3.23791339
35aromatic amino acid family catabolic process (GO:0009074)3.21457017
36complement activation, alternative pathway (GO:0006957)3.21284826
37positive regulation of fatty acid beta-oxidation (GO:0032000)3.20261496
38regulation of cholesterol storage (GO:0010885)3.14490050
39kynurenine metabolic process (GO:0070189)3.14315544
40positive regulation of glycolytic process (GO:0045821)3.13486677
41cysteine metabolic process (GO:0006534)3.11531638
422-oxoglutarate metabolic process (GO:0006103)3.10456337
43glycoprotein catabolic process (GO:0006516)3.09683179
44amino-acid betaine metabolic process (GO:0006577)3.08388331
45regulation of protein activation cascade (GO:2000257)3.07124799
46Rap protein signal transduction (GO:0032486)3.06550497
47high-density lipoprotein particle remodeling (GO:0034375)3.05196537
48reverse cholesterol transport (GO:0043691)3.05138341
49negative regulation of fibrinolysis (GO:0051918)3.03486275
50low-density lipoprotein particle clearance (GO:0034383)3.00609084
51glyoxylate metabolic process (GO:0046487)3.00422378
52response to peptidoglycan (GO:0032494)2.99135099
53lipoprotein transport (GO:0042953)2.98867821
54L-alpha-amino acid transmembrane transport (GO:1902475)2.98444865
55cytoplasmic mRNA processing body assembly (GO:0033962)2.97884856
56vesicle coating (GO:0006901)2.97636523
57phospholipid scrambling (GO:0017121)2.96907166
58cilium or flagellum-dependent cell motility (GO:0001539)2.96100186
59apoptotic cell clearance (GO:0043277)2.95425471
60positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.94514109
61peptidyl-lysine dimethylation (GO:0018027)2.94513046
62regulation of complement activation (GO:0030449)2.93851130
63nuclear pore organization (GO:0006999)2.92793044
64sulfur amino acid catabolic process (GO:0000098)2.92723055
65plasma lipoprotein particle clearance (GO:0034381)2.91314286
66bile acid biosynthetic process (GO:0006699)2.90354458
67tricarboxylic acid metabolic process (GO:0072350)2.89028027
68phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.88452296
69phospholipid efflux (GO:0033700)2.88193439
70cellular response to thyroid hormone stimulus (GO:0097067)2.87828909
71neutrophil activation involved in immune response (GO:0002283)2.85939493
72positive regulation by symbiont of host defense response (GO:0052509)2.83165021
73modulation by symbiont of host defense response (GO:0052031)2.83165021
74modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.83165021
75modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.83165021
76positive regulation by organism of defense response of other organism involved in symbiotic interact2.83165021
77modulation by symbiont of host immune response (GO:0052553)2.83165021
78insulin-like growth factor receptor signaling pathway (GO:0048009)2.82033488
79cholesterol efflux (GO:0033344)2.81920521
80macrophage activation involved in immune response (GO:0002281)2.81553752
81tryptophan metabolic process (GO:0006568)2.81459693
82positive regulation of developmental pigmentation (GO:0048087)2.80461589
83negative regulation of cholesterol transport (GO:0032375)2.79041213
84negative regulation of sterol transport (GO:0032372)2.79041213
85glutamate metabolic process (GO:0006536)2.77474370
86midgut development (GO:0007494)2.76516263
87positive regulation of histone deacetylation (GO:0031065)2.74787368
88COPII vesicle coating (GO:0048208)2.74611257
89bile acid metabolic process (GO:0008206)2.73532861
90regulation of clathrin-mediated endocytosis (GO:2000369)2.72535484
91lipoprotein metabolic process (GO:0042157)2.71983837
92detection of molecule of bacterial origin (GO:0032490)2.71581466
93tryptophan catabolic process (GO:0006569)2.71215514
94indole-containing compound catabolic process (GO:0042436)2.71215514
95indolalkylamine catabolic process (GO:0046218)2.71215514
96positive regulation of fatty acid oxidation (GO:0046321)2.71016614
97short-chain fatty acid metabolic process (GO:0046459)2.69516554
98protein-lipid complex assembly (GO:0065005)2.68331551
99histone H3-K9 demethylation (GO:0033169)2.68121135
100cellular modified amino acid catabolic process (GO:0042219)2.67361124
101regulation of fatty acid oxidation (GO:0046320)2.65784307
102alanine transport (GO:0032328)2.65500965
103NLS-bearing protein import into nucleus (GO:0006607)2.64538902
104regulation of membrane lipid distribution (GO:0097035)2.64032906
105positive regulation of lipid catabolic process (GO:0050996)2.63926402
106positive regulation of glycogen biosynthetic process (GO:0045725)2.63772059
107plasma lipoprotein particle assembly (GO:0034377)2.62095294
108tyrosine metabolic process (GO:0006570)2.60077951
109regulation of fibrinolysis (GO:0051917)2.59645923
110epithelial cell differentiation involved in prostate gland development (GO:0060742)2.58949533
111pore complex assembly (GO:0046931)2.58761249
112cellular ketone body metabolic process (GO:0046950)2.58297450
113carnitine metabolic process (GO:0009437)2.57451352
114regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.57367611
115response to muramyl dipeptide (GO:0032495)2.55563834
116valine metabolic process (GO:0006573)2.55470254
117positive regulation of leukocyte degranulation (GO:0043302)2.55427676
118activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.54997682
119regulation of macrophage chemotaxis (GO:0010758)2.54766531
120N-glycan processing (GO:0006491)2.54305594
121acetyl-CoA metabolic process (GO:0006084)2.53849356
122nerve growth factor signaling pathway (GO:0038180)2.53753275
123plasma lipoprotein particle remodeling (GO:0034369)2.53483774
124protein-lipid complex remodeling (GO:0034368)2.53483774
125macromolecular complex remodeling (GO:0034367)2.53483774
126positive regulation of cellular amide metabolic process (GO:0034250)2.53298187
127drug catabolic process (GO:0042737)2.52721231
128fatty acid beta-oxidation (GO:0006635)2.50627061
129regulation of triglyceride catabolic process (GO:0010896)2.50327476
130fatty acid transmembrane transport (GO:1902001)2.50101174
131Golgi to endosome transport (GO:0006895)2.49289141
132triglyceride homeostasis (GO:0070328)2.48268047
133acylglycerol homeostasis (GO:0055090)2.48268047
134I-kappaB phosphorylation (GO:0007252)2.48091372
135mannose metabolic process (GO:0006013)2.46940374
136iron ion import (GO:0097286)2.46828555
137protein targeting to lysosome (GO:0006622)2.46726026
138establishment of protein localization to vacuole (GO:0072666)2.46726026
139protein targeting to vacuole (GO:0006623)2.46726026
140serine family amino acid catabolic process (GO:0009071)2.46511963
141regulation of pigment cell differentiation (GO:0050932)2.46483552
142histone lysine demethylation (GO:0070076)2.45718580
1434-hydroxyproline metabolic process (GO:0019471)2.45675632
144regulation of lipid catabolic process (GO:0050994)2.45195172
145regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.44960859
146regulation of protein polyubiquitination (GO:1902914)2.44704562
147regulation of mononuclear cell migration (GO:0071675)2.43155612
148positive regulation of nuclease activity (GO:0032075)2.42307855
149positive regulation of interferon-alpha production (GO:0032727)2.41236500
150fatty acid oxidation (GO:0019395)2.41070473
151fatty acid homeostasis (GO:0055089)2.40602445
152interkinetic nuclear migration (GO:0022027)2.40004831
153cellular extravasation (GO:0045123)2.39760364
154regulation of B cell differentiation (GO:0045577)2.39663737
155intracellular lipid transport (GO:0032365)2.39352955
156regulation of interferon-alpha production (GO:0032647)2.38526922
157prenylation (GO:0097354)2.37750031
158protein prenylation (GO:0018342)2.37750031
159histone demethylation (GO:0016577)2.37369465
160positive regulation of toll-like receptor signaling pathway (GO:0034123)2.37273371
161regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.34756325
162regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.33787702
163positive regulation of B cell differentiation (GO:0045579)2.32641648
164production of molecular mediator involved in inflammatory response (GO:0002532)2.31898469
165early endosome to late endosome transport (GO:0045022)2.29130282
166pathway-restricted SMAD protein phosphorylation (GO:0060389)2.29050553
167gastrulation with mouth forming second (GO:0001702)2.27945798
168positive regulation of chemokine secretion (GO:0090197)2.27714931
169B cell homeostasis (GO:0001782)2.26843324
170monoubiquitinated protein deubiquitination (GO:0035520)2.25407648
171histamine secretion (GO:0001821)2.25218370
172myelin assembly (GO:0032288)2.24943483
173cell adhesion mediated by integrin (GO:0033627)2.24171891
174determination of adult lifespan (GO:0008340)2.24091616
175B cell proliferation (GO:0042100)2.23082842
176regulation of gamma-delta T cell activation (GO:0046643)2.22088820
177positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)2.21902986
178phosphatidylinositol dephosphorylation (GO:0046856)2.20670888
179regulation of interferon-beta production (GO:0032648)2.20461089
180detection of other organism (GO:0098543)2.20303607
181regulation of Golgi to plasma membrane protein transport (GO:0042996)2.19205280
182N-acetylneuraminate metabolic process (GO:0006054)2.18987608
183regulation of interferon-beta biosynthetic process (GO:0045357)2.18402742
184germinal center formation (GO:0002467)2.18088750
185protein localization to endosome (GO:0036010)2.17752422
186regulation of Rac protein signal transduction (GO:0035020)2.14739469
187positive regulation of mast cell activation (GO:0033005)2.13816730
188definitive hemopoiesis (GO:0060216)2.13803232
189histone H3-K9 methylation (GO:0051567)2.12762905
190epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.12712706
191immunoglobulin mediated immune response (GO:0016064)2.12244732
192regulation of chemokine secretion (GO:0090196)2.11787846
193glycosphingolipid catabolic process (GO:0046479)2.11771035
194necroptotic process (GO:0070266)2.10828880
195phospholipid dephosphorylation (GO:0046839)2.10605297
196detection of external biotic stimulus (GO:0098581)2.09989930
197negative regulation of neurotransmitter transport (GO:0051589)2.09611481
198cellular response to exogenous dsRNA (GO:0071360)2.08867975
199histone H3-K4 trimethylation (GO:0080182)2.08686165

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.79380435
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.47594402
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.23508044
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.86742143
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.79239900
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.51096523
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.88736540
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.82247905
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.80787848
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.77503907
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.58347381
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.56795338
13CLOCK_20551151_ChIP-Seq_293T_Human2.56312477
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.18044824
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.11307621
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.10559261
17GATA1_22025678_ChIP-Seq_K562_Human2.08941430
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.07655489
19MYB_21317192_ChIP-Seq_ERMYB_Mouse1.97887604
20FOXA2_19822575_ChIP-Seq_HepG2_Human1.97741863
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96843708
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.93626425
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76830207
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.76574731
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75373448
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.74740899
27VDR_24787735_ChIP-Seq_THP-1_Human1.72870252
28EGR1_23403033_ChIP-Seq_LIVER_Mouse1.71101964
29DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.70771692
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.65114879
31* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.65025614
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61405484
33* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60658652
34NRF2_20460467_ChIP-Seq_MEFs_Mouse1.59491834
35NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.59491834
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58709756
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56353933
38WT1_19549856_ChIP-ChIP_CCG9911_Human1.56099703
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.54492634
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52948343
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52626083
42BRD4_25478319_ChIP-Seq_HGPS_Human1.52518479
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.52491580
44TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.50802207
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.47387682
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.44015047
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42290631
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41287652
49PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40482377
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38343373
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.37294523
52PU_27001747_Chip-Seq_BMDM_Mouse1.37155982
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36004034
54P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34963788
55RUNX_20019798_ChIP-Seq_JUKART_Human1.34434838
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34313848
57NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.33015732
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.32454833
59DROSHA_22980978_ChIP-Seq_HELA_Human1.32300226
60TCF7_22412390_ChIP-Seq_EML_Mouse1.30591980
61* FUS_26573619_Chip-Seq_HEK293_Human1.30529491
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30474262
63CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29522326
64TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28773234
65SOX2_27498859_Chip-Seq_STOMACH_Mouse1.28730083
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28335436
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27837255
68SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27704958
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27429244
70STAT3_23295773_ChIP-Seq_U87_Human1.27412563
71KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25764354
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25504516
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24843067
74HNF4A_19822575_ChIP-Seq_HepG2_Human1.24396257
75TAF15_26573619_Chip-Seq_HEK293_Human1.23967305
76ESR2_21235772_ChIP-Seq_MCF-7_Human1.23723821
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.22946231
78IGF1R_20145208_ChIP-Seq_DFB_Human1.22885735
79NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21645718
80* EWS_26573619_Chip-Seq_HEK293_Human1.21203991
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.19471257
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19467613
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18941079
84ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18778486
85TP63_23658742_ChIP-Seq_EP156T_Human1.18602213
86SPI1_23547873_ChIP-Seq_NB4_Human1.18351568
87ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18043011
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16949960
89SCL_19346495_ChIP-Seq_HPC-7_Human1.15959190
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15838858
91ESR1_20079471_ChIP-ChIP_T-47D_Human1.15593333
92ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15470009
93AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15042439
94KDM2B_26808549_Chip-Seq_DND41_Human1.14837283
95MYC_22102868_ChIP-Seq_BL_Human1.13833423
96CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13582887
97IRF8_22096565_ChIP-ChIP_GC-B_Human1.13337746
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13309515
99MYB_26560356_Chip-Seq_TH2_Human1.12395487
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12175759
101SMAD4_21799915_ChIP-Seq_A2780_Human1.12062126
102NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11726508
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.11570157
104FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11345954
105FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11207569
106GBX2_23144817_ChIP-Seq_PC3_Human1.11173444
107WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10179061
108TBX20_22080862_ChIP-Seq_HEART_Mouse1.09937496
109TBX20_22328084_ChIP-Seq_HEART_Mouse1.09937496
110PIAS1_25552417_ChIP-Seq_VCAP_Human1.09590033
111ZNF263_19887448_ChIP-Seq_K562_Human1.09266994
112KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09240289
113SPI1_23127762_ChIP-Seq_K562_Human1.09186860
114EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08487689
115TRIM28_21343339_ChIP-Seq_HEK293_Human1.07891308
116SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07696289
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07326187
118CMYC_18555785_Chip-Seq_ESCs_Mouse1.06532098
119PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06329744
120SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04060225
121NFE2_27457419_Chip-Seq_LIVER_Mouse1.03984839
122GATA1_19941826_ChIP-Seq_K562_Human1.03731593
123GATA6_25053715_ChIP-Seq_YYC3_Human1.03688739
124PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03479920
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03478375
126RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03067798
127* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02874694
128FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.02632676
129GATA3_27048872_Chip-Seq_THYMUS_Human1.01732870
130* IRF8_27001747_Chip-Seq_BMDM_Mouse1.01696605
131E2F1_18555785_Chip-Seq_ESCs_Mouse1.01224700
132CRX_20693478_ChIP-Seq_RETINA_Mouse1.00917978
133* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00904000
134AHR_22903824_ChIP-Seq_MCF-7_Human1.00863884
135* P300_19829295_ChIP-Seq_ESCs_Human1.00658709
136PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00519212
137SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99676878
138SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99676878
139EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99516037
140FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99495157
141GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98871516
142TCF4_23295773_ChIP-Seq_U87_Human0.98599014
143LXR_22292898_ChIP-Seq_THP-1_Human0.97953659
144KDM2B_26808549_Chip-Seq_K562_Human0.97570290
145SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96934485
146KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96829460
147CDX2_22108803_ChIP-Seq_LS180_Human0.96662405
148CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96374112
149SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95501618
150ARNT_22903824_ChIP-Seq_MCF-7_Human0.95389871
151E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94726291
152FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93784716
153CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93130375
154ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91953156
155FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.91371776
156* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90239811
157KDM2B_26808549_Chip-Seq_JURKAT_Human0.90215586
158CREB1_26743006_Chip-Seq_LNCaP_Human0.89689500
159ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89590634
160ELK4_26923725_Chip-Seq_MESODERM_Mouse0.88723876
161GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.88378247
162VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88298001
163SOX2_21211035_ChIP-Seq_LN229_Gbm0.87948982
164PPAR_26484153_Chip-Seq_NCI-H1993_Human0.87829833
165* ISL1_27105846_Chip-Seq_CPCs_Mouse0.87332063
166TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87213755
167BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86576953
168GATA2_21666600_ChIP-Seq_HMVEC_Human0.86393298
169PKCTHETA_26484144_Chip-Seq_BREAST_Human0.85887545
170TP53_16413492_ChIP-PET_HCT116_Human0.85328628
171CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85134463

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.06878473
2MP0002139_abnormal_hepatobiliary_system4.87238621
3MP0005360_urolithiasis4.66772841
4MP0005365_abnormal_bile_salt3.84515524
5MP0010234_abnormal_vibrissa_follicle3.74320103
6MP0003705_abnormal_hypodermis_morpholog3.50363392
7MP0005085_abnormal_gallbladder_physiolo3.30897037
8MP0003252_abnormal_bile_duct3.06442909
9MP0002396_abnormal_hematopoietic_system3.01078439
10MP0008057_abnormal_DNA_replication2.94621104
11MP0010329_abnormal_lipoprotein_level2.71249010
12MP0008875_abnormal_xenobiotic_pharmacok2.71093414
13MP0005058_abnormal_lysosome_morphology2.69542145
14MP0003172_abnormal_lysosome_physiology2.69112072
15MP0001835_abnormal_antigen_presentation2.64038181
16MP0003656_abnormal_erythrocyte_physiolo2.63620748
17MP0002009_preneoplasia2.62286534
18MP0009840_abnormal_foam_cell2.49834384
19MP0003191_abnormal_cellular_cholesterol2.33647518
20MP0003828_pulmonary_edema2.22832053
21MP0003183_abnormal_peptide_metabolism2.16495092
22MP0004130_abnormal_muscle_cell1.92760574
23MP0005464_abnormal_platelet_physiology1.92590097
24MP0001790_abnormal_immune_system1.92491158
25MP0005387_immune_system_phenotype1.92491158
26MP0005083_abnormal_biliary_tract1.88913942
27MP0003300_gastrointestinal_ulcer1.84992083
28MP0001800_abnormal_humoral_immune1.76062980
29MP0000383_abnormal_hair_follicle1.75091891
30MP0009780_abnormal_chondrocyte_physiolo1.73167893
31MP0004808_abnormal_hematopoietic_stem1.71578503
32MP0002419_abnormal_innate_immunity1.70370161
33MP0000609_abnormal_liver_physiology1.65295838
34MP0002405_respiratory_system_inflammati1.65133864
35MP0002452_abnormal_antigen_presenting1.65023018
36MP0000465_gastrointestinal_hemorrhage1.64888418
37MP0005076_abnormal_cell_differentiation1.63105385
38MP0010368_abnormal_lymphatic_system1.59793813
39MP0001666_abnormal_nutrient_absorption1.56428649
40MP0003724_increased_susceptibility_to1.55316984
41MP0002118_abnormal_lipid_homeostasis1.51230385
42MP0005670_abnormal_white_adipose1.50867658
43MP0003195_calcinosis1.50435410
44MP0008961_abnormal_basal_metabolism1.49984301
45MP0003436_decreased_susceptibility_to1.49976893
46MP0010352_gastrointestinal_tract_polyps1.48376371
47MP0004185_abnormal_adipocyte_glucose1.47172136
48MP0000685_abnormal_immune_system1.46648137
49MP0005332_abnormal_amino_acid1.46594998
50MP0005310_abnormal_salivary_gland1.46357876
51MP0000604_amyloidosis1.42648158
52MP0005000_abnormal_immune_tolerance1.41682719
53MP0002909_abnormal_adrenal_gland1.39072630
54MP0004947_skin_inflammation1.38858151
55MP0002723_abnormal_immune_serum1.38528341
56MP0005666_abnormal_adipose_tissue1.33225612
57MP0000003_abnormal_adipose_tissue1.30963120
58MP0003868_abnormal_feces_composition1.30782629
59MP0003448_altered_tumor_morphology1.29992161
60MP0005671_abnormal_response_to1.29755683
61MP0000013_abnormal_adipose_tissue1.28724886
62MP0001819_abnormal_immune_cell1.27603850
63MP0002420_abnormal_adaptive_immunity1.26894886
64MP0003566_abnormal_cell_adhesion1.23682868
65MP0008007_abnormal_cellular_replicative1.21259099
66MP0003950_abnormal_plasma_membrane1.20054415
67MP0000537_abnormal_urethra_morphology1.19461629
68MP0006082_CNS_inflammation1.17358365
69MP0003453_abnormal_keratinocyte_physiol1.17069235
70MP0000371_diluted_coat_color1.16150431
71MP0005375_adipose_tissue_phenotype1.16140194
72MP0002090_abnormal_vision1.16112117
73MP0009672_abnormal_birth_weight1.15799765
74MP0004233_abnormal_muscle_weight1.15496995
75MP0002006_tumorigenesis1.14024850
76MP0001756_abnormal_urination1.13192439
77MP0000689_abnormal_spleen_morphology1.12201747
78MP0004264_abnormal_extraembryonic_tissu1.12004610
79MP0002928_abnormal_bile_duct1.11241182
80MP0003763_abnormal_thymus_physiology1.10221362
81MP0010307_abnormal_tumor_latency1.07956380
82MP0008438_abnormal_cutaneous_collagen1.07449650
83MP0009643_abnormal_urine_homeostasis1.06509923
84MP0002148_abnormal_hypersensitivity_rea1.06340622
85MP0009697_abnormal_copulation1.05717657
86MP0008260_abnormal_autophagy1.05279870
87MP0002078_abnormal_glucose_homeostasis1.05243734
88MP0005319_abnormal_enzyme/_coenzyme1.04874351
89MP0001845_abnormal_inflammatory_respons1.03730012
90MP0005025_abnormal_response_to1.03485005
91MP0001545_abnormal_hematopoietic_system1.03431404
92MP0005397_hematopoietic_system_phenotyp1.03431404
93MP0009785_altered_susceptibility_to1.02387749
94MP0002398_abnormal_bone_marrow1.02210674
95MP0005623_abnormal_meninges_morphology1.01411436
96MP0002998_abnormal_bone_remodeling1.00676197
97MP0000598_abnormal_liver_morphology0.99031189
98MP0003690_abnormal_glial_cell0.98085190
99MP0010386_abnormal_urinary_bladder0.97191747
100MP0000716_abnormal_immune_system0.96979094
101MP0005187_abnormal_penis_morphology0.92984499
102MP0004019_abnormal_vitamin_homeostasis0.92336547
103MP0010155_abnormal_intestine_physiology0.91064809
104MP0003045_fibrosis0.90933627
105MP0005167_abnormal_blood-brain_barrier0.89920514
106MP0005621_abnormal_cell_physiology0.89481303
107MP0001915_intracranial_hemorrhage0.89385975
108MP0003890_abnormal_embryonic-extraembry0.88758879
109MP0002722_abnormal_immune_system0.87347365
110MP0008004_abnormal_stomach_pH0.86226774
111MP0001849_ear_inflammation0.85166565
112MP0002166_altered_tumor_susceptibility0.84209163
113MP0002269_muscular_atrophy0.83223501
114MP0002971_abnormal_brown_adipose0.83045109
115MP0003123_paternal_imprinting0.83013910
116MP0002168_other_aberrant_phenotype0.82745989
117MP0002877_abnormal_melanocyte_morpholog0.82579156
118MP0009053_abnormal_anal_canal0.82456827
119MP0010678_abnormal_skin_adnexa0.81957069
120MP0003283_abnormal_digestive_organ0.81157326
121MP0002254_reproductive_system_inflammat0.80965504
122MP0000538_abnormal_urinary_bladder0.80607523
123MP0000858_altered_metastatic_potential0.80583076
124MP0004883_abnormal_blood_vessel0.80498437
125MP0005584_abnormal_enzyme/coenzyme_acti0.80327912
126MP0004858_abnormal_nervous_system0.80068686
127MP0006054_spinal_hemorrhage0.79828864
128MP0002429_abnormal_blood_cell0.79624750
129MP0005334_abnormal_fat_pad0.79308556
130MP0003303_peritoneal_inflammation0.78986617
131MP0005408_hypopigmentation0.78120646
132MP0000516_abnormal_urinary_system0.77661944
133MP0005367_renal/urinary_system_phenotyp0.77661944
134MP0001853_heart_inflammation0.77568578
135MP0003632_abnormal_nervous_system0.77460972
136MP0003115_abnormal_respiratory_system0.77459577
137MP0002133_abnormal_respiratory_system0.76234782
138MP0005388_respiratory_system_phenotype0.76234782
139MP0001533_abnormal_skeleton_physiology0.75510687
140MP0003984_embryonic_growth_retardation0.74885805
141MP0002088_abnormal_embryonic_growth/wei0.72711279
142MP0005257_abnormal_intraocular_pressure0.72119887
143MP0000343_altered_response_to0.71983893
144MP0005275_abnormal_skin_tensile0.71731395
145MP0001661_extended_life_span0.71122825
146MP0003795_abnormal_bone_structure0.69917071
147MP0002837_dystrophic_cardiac_calcinosis0.69712390
148MP0008469_abnormal_protein_level0.69009952
149MP0005448_abnormal_energy_balance0.68635632
150MP0005384_cellular_phenotype0.66813056
151MP0004272_abnormal_basement_membrane0.66299230
152MP0002970_abnormal_white_adipose0.66278422
153MP0009703_decreased_birth_body0.66225476
154MP0001879_abnormal_lymphatic_vessel0.66096958
155MP0002896_abnormal_bone_mineralization0.65115143
156MP0000427_abnormal_hair_cycle0.65033365
157MP0001324_abnormal_eye_pigmentation0.63763183
158MP0005535_abnormal_body_temperature0.62809945
159MP0003091_abnormal_cell_migration0.61399738
160MP0005248_abnormal_Harderian_gland0.60237682
161MP0002138_abnormal_hepatobiliary_system0.59795040
162MP0002697_abnormal_eye_size0.59529934
163MP0003806_abnormal_nucleotide_metabolis0.58266654
164MP0005220_abnormal_exocrine_pancreas0.57407061
165MP0004043_abnormal_pH_regulation0.57369755
166MP0009115_abnormal_fat_cell0.56690746
167MP0002086_abnormal_extraembryonic_tissu0.56221756

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)3.99997906
2Complement deficiency (HP:0004431)3.57132793
3Papillary thyroid carcinoma (HP:0002895)3.43777967
4Xanthomatosis (HP:0000991)3.38843789
5Intrahepatic cholestasis (HP:0001406)3.30398933
6Recurrent bacterial skin infections (HP:0005406)3.21635510
7Abnormality of glycolipid metabolism (HP:0010969)3.07316350
8Abnormality of liposaccharide metabolism (HP:0010968)3.07316350
9Abnormality of glycosphingolipid metabolism (HP:0004343)3.07316350
10Hypoglycemic coma (HP:0001325)3.06886133
11Hypoglycemic seizures (HP:0002173)3.04573794
12Ketosis (HP:0001946)3.01355214
13Abnormality of the vasculature of the conjunctiva (HP:0008054)2.98636339
14Abnormality of aromatic amino acid family metabolism (HP:0004338)2.97859025
15Cerebral aneurysm (HP:0004944)2.97535875
16Epidermoid cyst (HP:0200040)2.93806996
17Hypoalphalipoproteinemia (HP:0003233)2.89705707
18Recurrent abscess formation (HP:0002722)2.86861821
19Global brain atrophy (HP:0002283)2.82808787
20Vacuolated lymphocytes (HP:0001922)2.78457490
21Mitral stenosis (HP:0001718)2.75824313
22Skin nodule (HP:0200036)2.73893350
23Abnormality of monocarboxylic acid metabolism (HP:0010996)2.73530677
24Hyperlipoproteinemia (HP:0010980)2.71521848
25Eczematoid dermatitis (HP:0000976)2.67911959
26Gastrointestinal stroma tumor (HP:0100723)2.64595703
27Spontaneous hematomas (HP:0007420)2.63554775
28Ketoacidosis (HP:0001993)2.61637343
29Long toe (HP:0010511)2.60035295
30Upper motor neuron abnormality (HP:0002127)2.59477062
31Spastic diplegia (HP:0001264)2.57065881
32Myocardial infarction (HP:0001658)2.56527299
33Colitis (HP:0002583)2.55586884
34Hypolipoproteinemia (HP:0010981)2.53970546
35Turricephaly (HP:0000262)2.52488528
36Recurrent sinusitis (HP:0011108)2.52333132
37Abnormality of sulfur amino acid metabolism (HP:0004339)2.51167412
38Lymphangioma (HP:0100764)2.49428323
39Abnormality of complement system (HP:0005339)2.43998270
40Abnormality of macrophages (HP:0004311)2.42462945
41Hypobetalipoproteinemia (HP:0003563)2.42292962
42Abnormality of the lower motor neuron (HP:0002366)2.41205954
43Macroorchidism (HP:0000053)2.39992367
44Thyroid carcinoma (HP:0002890)2.39407465
45Conjunctival telangiectasia (HP:0000524)2.35943037
46T lymphocytopenia (HP:0005403)2.35877268
47Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.34659109
48Viral hepatitis (HP:0006562)2.30928923
49Aneurysm (HP:0002617)2.30596790
50Abnormality of the common coagulation pathway (HP:0010990)2.30302995
51Conjugated hyperbilirubinemia (HP:0002908)2.28470184
52Hypercholesterolemia (HP:0003124)2.27458845
53Abnormality of glutamine family amino acid metabolism (HP:0010902)2.23950986
54Hyperammonemia (HP:0001987)2.23831598
55Thoracolumbar scoliosis (HP:0002944)2.23107244
56Abnormality of the intrinsic pathway (HP:0010989)2.22067894
57Hyperglycinemia (HP:0002154)2.21173350
58Increased cerebral lipofuscin (HP:0011813)2.20832819
59Recurrent viral infections (HP:0004429)2.20736467
60Thoracic kyphosis (HP:0002942)2.19619258
61Gingivitis (HP:0000230)2.18923915
62Dynein arm defect of respiratory motile cilia (HP:0012255)2.18772277
63Absent/shortened dynein arms (HP:0200106)2.18772277
64Systemic lupus erythematosus (HP:0002725)2.18080220
65Hepatocellular carcinoma (HP:0001402)2.16696061
66Abnormality of T cell number (HP:0011839)2.15794127
67Acute myeloid leukemia (HP:0004808)2.11936727
68Abnormality of the periventricular white matter (HP:0002518)2.10548805
69Subacute progressive viral hepatitis (HP:0006572)2.09163216
70Enlarged penis (HP:0000040)2.08957150
71Sensorimotor neuropathy (HP:0007141)2.08813302
72Fatigue (HP:0012378)2.08769657
73Abnormality of the lumbar spine (HP:0100712)2.08444399
74Transitional cell carcinoma of the bladder (HP:0006740)2.06347787
75Asymmetry of the thorax (HP:0001555)2.06168045
76Aortic aneurysm (HP:0004942)2.05864267
77Increased mean platelet volume (HP:0011877)2.05764029
78Abnormality of polysaccharide metabolism (HP:0011012)2.05675730
79Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05675730
80Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05675730
81Urinary glycosaminoglycan excretion (HP:0003541)2.04931014
82Mucopolysacchariduria (HP:0008155)2.04931014
83Retinal atrophy (HP:0001105)2.04619153
84Hand muscle atrophy (HP:0009130)2.03906812
85Hyperglycemia (HP:0003074)2.03003732
86Neonatal hypoglycemia (HP:0001998)2.01977985
87Abnormality of purine metabolism (HP:0004352)2.01771402
88Hyperinsulinemic hypoglycemia (HP:0000825)1.99219432
89Thickened calvaria (HP:0002684)1.99180485
90Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.98836040
91Widely spaced teeth (HP:0000687)1.97420539
92Dysostosis multiplex (HP:0000943)1.93993293
93Abnormal platelet volume (HP:0011876)1.93872125
94Loss of speech (HP:0002371)1.93853685
95Autoimmune hemolytic anemia (HP:0001890)1.93614446
96Buphthalmos (HP:0000557)1.92190950
97Recurrent skin infections (HP:0001581)1.91462197
98Esophageal varix (HP:0002040)1.90602180
99Portal hypertension (HP:0001409)1.90469369
100Abnormality of serine family amino acid metabolism (HP:0010894)1.89946299
101Abnormality of glycine metabolism (HP:0010895)1.89946299
102Flat acetabular roof (HP:0003180)1.89747578
103Bilateral sensorineural hearing impairment (HP:0008619)1.89689937
104Coarse hair (HP:0002208)1.87671577
105Hyperacusis (HP:0010780)1.87084488
106Curly hair (HP:0002212)1.87006684
107Thick nail (HP:0001805)1.86687868
108Short 4th metacarpal (HP:0010044)1.85186079
109Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.85186079
110Vasculitis (HP:0002633)1.84347850
111Bladder carcinoma (HP:0002862)1.83958537
112Bladder neoplasm (HP:0009725)1.83958537
113Axonal loss (HP:0003447)1.83934263
114Symptomatic seizures (HP:0011145)1.83600415
115IgA deficiency (HP:0002720)1.83531122
116Vertebral arch anomaly (HP:0008438)1.82916062
117Increased CSF protein (HP:0002922)1.82383258
118Absent frontal sinuses (HP:0002688)1.81843946
119Abnormality of the 4th metacarpal (HP:0010012)1.81672692
120Periodontitis (HP:0000704)1.81645617
121Abnormality of the prostate (HP:0008775)1.81414321
122Striae distensae (HP:0001065)1.81293512
123Renovascular hypertension (HP:0100817)1.80626251
124Prostate neoplasm (HP:0100787)1.79887965
125Mucosal telangiectasiae (HP:0100579)1.79139013
126Chronic hepatic failure (HP:0100626)1.78944571
127Inflammation of the large intestine (HP:0002037)1.78463765
128Recurrent cutaneous fungal infections (HP:0011370)1.78274817
129Chronic mucocutaneous candidiasis (HP:0002728)1.78274817
130Gingival bleeding (HP:0000225)1.77921795
131Autoimmune thrombocytopenia (HP:0001973)1.77873640
132Submucous cleft hard palate (HP:0000176)1.77820514
133Epistaxis (HP:0000421)1.77670480
134Disinhibition (HP:0000734)1.77410967
135Mediastinal lymphadenopathy (HP:0100721)1.75426847
136Upper limb amyotrophy (HP:0009129)1.74867099
137Distal upper limb amyotrophy (HP:0007149)1.74867099
138Death in childhood (HP:0003819)1.74736606
139Protruding tongue (HP:0010808)1.73782286
140Cortical dysplasia (HP:0002539)1.73525594
141Mitral valve prolapse (HP:0001634)1.72951490
142Abnormality of the thoracic spine (HP:0100711)1.72738755
143Hyperglycinuria (HP:0003108)1.70605781
144Recurrent gram-negative bacterial infections (HP:0005420)1.67913844
145Limb hypertonia (HP:0002509)1.67482586
146Truncal obesity (HP:0001956)1.66784641
147Restrictive lung disease (HP:0002091)1.66118061
148Inappropriate behavior (HP:0000719)1.65883794
149Protuberant abdomen (HP:0001538)1.65860406
150Prolonged partial thromboplastin time (HP:0003645)1.65722731
151Hamartoma of the eye (HP:0010568)1.65315815
152Deep philtrum (HP:0002002)1.64924743
153Frequent falls (HP:0002359)1.64875907
154Spinal cord lesions (HP:0100561)1.64859560
155Syringomyelia (HP:0003396)1.64859560
156Elfin facies (HP:0004428)1.64315626
157Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.64308912
158Osteolytic defects of the hand bones (HP:0009699)1.64231208
159Osteolytic defects of the phalanges of the hand (HP:0009771)1.64231208
160Hydroxyprolinuria (HP:0003080)1.63974147
161Abnormality of proline metabolism (HP:0010907)1.63974147
162Menorrhagia (HP:0000132)1.63740856
163Hematochezia (HP:0002573)1.63400042
164Abnormality of the fingertips (HP:0001211)1.63066523
165Joint hemorrhage (HP:0005261)1.62294595
166Abnormality of nucleobase metabolism (HP:0010932)1.62183526
167Gastrointestinal inflammation (HP:0004386)1.62120464
168Relative macrocephaly (HP:0004482)1.61961992
169Asymmetric septal hypertrophy (HP:0001670)1.61853243
170Spondylolisthesis (HP:0003302)1.61537344
171Lymphopenia (HP:0001888)1.60833212
172Prolonged bleeding time (HP:0003010)1.60620094
173Abnormality of the hepatic vasculature (HP:0006707)1.60266425
174Pseudobulbar signs (HP:0002200)1.60205353
175Fair hair (HP:0002286)1.59687418
176Abnormality of the pancreatic islet cells (HP:0006476)1.58850970
177Abnormality of endocrine pancreas physiology (HP:0012093)1.58850970
178Stomach cancer (HP:0012126)1.58023822
179Neurodegeneration (HP:0002180)1.57487469
180Recurrent bronchitis (HP:0002837)1.57009930
181Resting tremor (HP:0002322)1.56923346
182Heterotopia (HP:0002282)1.54900331
183Neoplasm of the heart (HP:0100544)1.54473888
184Gout (HP:0001997)1.53886857
185Fat malabsorption (HP:0002630)1.53703826
186Peripheral demyelination (HP:0011096)1.53621421

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.62685461
2PKN23.16536829
3BLK3.15382615
4EIF2AK32.95764214
5MAP3K142.93334203
6PRKD32.69001136
7PTK62.52378734
8FRK2.42644218
9SIK12.37380065
10ERN12.33065776
11SCYL22.26041862
12CAMK1G2.18877414
13ACVR1B2.14915649
14PDGFRA2.02160512
15MAP3K102.01511959
16CAMK1D1.99264274
17RIPK11.93297176
18INSRR1.89810213
19LATS11.73310083
20IKBKE1.71880370
21RIPK41.69489923
22FGR1.65411537
23TTN1.64514520
24CDK121.63376426
25TAOK31.61658684
26NLK1.59086601
27FGFR41.57804743
28EEF2K1.56321560
29TEC1.52303746
30MAP3K131.49451903
31SGK31.41416344
32CSK1.39295125
33FGFR21.38982611
34MAP3K91.38476947
35KIT1.37492131
36NEK11.33770676
37PDK41.32682681
38PDK31.32682681
39MAP3K41.28317068
40KSR21.28062511
41YES11.26987030
42TNIK1.24324883
43BCKDK1.23171616
44CDK61.21137062
45BMPR21.15466121
46IRAK41.14585821
47RET1.13566722
48BTK1.13476879
49PRPF4B1.13289301
50CAMKK21.11741496
51MAP3K21.11425971
52PRKCH1.10626734
53STK381.09471868
54SGK21.05447816
55CAMKK11.05034755
56MAP4K11.04333936
57JAK11.03804231
58TRPM71.02949536
59DAPK21.02702184
60MATK1.01928618
61MTOR1.00700028
62ICK0.99671628
63ZAP700.98872333
64SIK20.98573438
65PTK20.98052350
66BRD40.97353499
67IRAK10.97098727
68LMTK20.96195041
69FER0.94818011
70PAK40.91291101
71TYK20.90524275
72IKBKB0.89880907
73FGFR30.89786981
74TGFBR20.89121266
75MKNK10.88702293
76ERBB30.87804228
77JAK30.86281356
78MELK0.85452267
79FGFR10.85389322
80EPHA30.85162929
81STK30.85036105
82SYK0.83458411
83NTRK30.83245361
84TBK10.81517647
85MKNK20.80589557
86PDGFRB0.80439087
87LYN0.78415350
88MAP2K40.76580780
89RPS6KA20.75547065
90TYRO30.75386623
91LRRK20.74525827
92JAK20.74025725
93HCK0.73997207
94PASK0.72061321
95MST40.70025022
96CHUK0.69659888
97PAK60.69167456
98LCK0.68306017
99STK240.67961467
100LATS20.67475002
101PDK20.67116196
102ERBB20.65938577
103FLT30.65766408
104PAK30.65523110
105DDR20.65340274
106PIM10.65011603
107NEK20.64370011
108ITK0.64011724
109PDK10.63415272
110EGFR0.62495367
111RPS6KA40.60373696
112ABL10.59535925
113NEK90.58691056
114SGK2230.58446973
115SGK4940.58446973
116ALK0.58077073
117CSF1R0.57557834
118MAP3K70.57556175
119FES0.57409514
120PRKAA10.56976453
121NTRK10.55670920
122GRK70.54285895
123WNK10.51911368
124STK38L0.48687343
125MAP2K10.47887934
126BMX0.47543869
127PRKAA20.47356215
128AKT30.47023813
129MAP3K80.46931379
130STK100.46486080
131ATM0.45977808
132PDPK10.45849320
133TXK0.45374866
134MARK30.44375695
135SGK10.44146426
136INSR0.43243982
137MAPK70.43161525
138CDK40.42937249
139TIE10.42877165
140CDC42BPA0.41159730
141IGF1R0.40058229
142MET0.40043390
143TGFBR10.39896378
144BRSK20.39661550
145DYRK1B0.39211581
146STK110.39043933
147PRKG20.38689182
148PTK2B0.38370553
149PRKD10.38071279
150MAPK110.37724444
151HIPK20.37724285
152CDK90.36720249
153PAK20.36624200
154BMPR1B0.35138642
155EIF2AK20.33884118

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.70995605
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.86794858
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.66824569
4Arginine biosynthesis_Homo sapiens_hsa002202.39514740
5Other glycan degradation_Homo sapiens_hsa005112.36298516
6Fatty acid degradation_Homo sapiens_hsa000712.14565104
7Leishmaniasis_Homo sapiens_hsa051402.01971745
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.97460828
9Lysine degradation_Homo sapiens_hsa003101.95389067
10B cell receptor signaling pathway_Homo sapiens_hsa046621.88556085
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85387025
12Tryptophan metabolism_Homo sapiens_hsa003801.78448339
13Complement and coagulation cascades_Homo sapiens_hsa046101.77908508
14PPAR signaling pathway_Homo sapiens_hsa033201.73921538
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.68471158
16Butanoate metabolism_Homo sapiens_hsa006501.68188521
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.66151190
18Propanoate metabolism_Homo sapiens_hsa006401.66104490
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62069033
20Asthma_Homo sapiens_hsa053101.61548736
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.59253141
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.58382003
23Fatty acid metabolism_Homo sapiens_hsa012121.55916615
24Bile secretion_Homo sapiens_hsa049761.55656789
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.54151914
26Toxoplasmosis_Homo sapiens_hsa051451.53881971
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.51970817
28Caffeine metabolism_Homo sapiens_hsa002321.50766454
29Allograft rejection_Homo sapiens_hsa053301.47605739
30Selenocompound metabolism_Homo sapiens_hsa004501.45843165
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.43767335
32Staphylococcus aureus infection_Homo sapiens_hsa051501.41610207
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.40076679
34ABC transporters_Homo sapiens_hsa020101.38994516
35Graft-versus-host disease_Homo sapiens_hsa053321.38545290
36Tuberculosis_Homo sapiens_hsa051521.38374362
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.37695964
38Autoimmune thyroid disease_Homo sapiens_hsa053201.35607217
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34768397
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.32524733
41Insulin resistance_Homo sapiens_hsa049311.31079111
42TNF signaling pathway_Homo sapiens_hsa046681.30462280
43Platelet activation_Homo sapiens_hsa046111.26994255
44Type II diabetes mellitus_Homo sapiens_hsa049301.23537036
45Hematopoietic cell lineage_Homo sapiens_hsa046401.23013503
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20957099
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20621009
48Type I diabetes mellitus_Homo sapiens_hsa049401.18438720
49Pyruvate metabolism_Homo sapiens_hsa006201.15665972
50Carbon metabolism_Homo sapiens_hsa012001.14642058
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13669316
52Hepatitis B_Homo sapiens_hsa051611.13381060
53mTOR signaling pathway_Homo sapiens_hsa041501.12883068
54Non-homologous end-joining_Homo sapiens_hsa034501.10788045
55Herpes simplex infection_Homo sapiens_hsa051681.10413187
56Starch and sucrose metabolism_Homo sapiens_hsa005001.09103722
57Phagosome_Homo sapiens_hsa041451.07441168
58Peroxisome_Homo sapiens_hsa041461.07042739
59Lysosome_Homo sapiens_hsa041421.06499088
60Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06461493
61Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05310001
62Influenza A_Homo sapiens_hsa051641.05082801
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03451130
64Prostate cancer_Homo sapiens_hsa052150.99026018
65Measles_Homo sapiens_hsa051620.98358218
66Glucagon signaling pathway_Homo sapiens_hsa049220.98116163
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.96308948
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.95062231
69Acute myeloid leukemia_Homo sapiens_hsa052210.94421827
70Rheumatoid arthritis_Homo sapiens_hsa053230.94401399
71Biosynthesis of amino acids_Homo sapiens_hsa012300.93816310
72Antigen processing and presentation_Homo sapiens_hsa046120.93311680
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92477873
74beta-Alanine metabolism_Homo sapiens_hsa004100.91796645
75Chemokine signaling pathway_Homo sapiens_hsa040620.90857830
76Sphingolipid metabolism_Homo sapiens_hsa006000.90049277
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89592870
78Legionellosis_Homo sapiens_hsa051340.89403104
79Hepatitis C_Homo sapiens_hsa051600.89334105
80Fat digestion and absorption_Homo sapiens_hsa049750.87394750
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87390594
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85554178
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85546460
84Glycerolipid metabolism_Homo sapiens_hsa005610.84784193
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83865703
86Pertussis_Homo sapiens_hsa051330.83642918
87MicroRNAs in cancer_Homo sapiens_hsa052060.81788019
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.80270170
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.78359670
90T cell receptor signaling pathway_Homo sapiens_hsa046600.76951873
91Malaria_Homo sapiens_hsa051440.76848131
92Prolactin signaling pathway_Homo sapiens_hsa049170.75682640
93Phenylalanine metabolism_Homo sapiens_hsa003600.75650411
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.75215233
95AMPK signaling pathway_Homo sapiens_hsa041520.72510244
96Insulin signaling pathway_Homo sapiens_hsa049100.72075909
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.71575935
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71527151
99Viral myocarditis_Homo sapiens_hsa054160.71484695
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71319920
101Apoptosis_Homo sapiens_hsa042100.70545548
102Colorectal cancer_Homo sapiens_hsa052100.69783495
103Sulfur metabolism_Homo sapiens_hsa009200.69624644
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68882192
105Insulin secretion_Homo sapiens_hsa049110.68426764
106Fatty acid biosynthesis_Homo sapiens_hsa000610.68067968
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.66099638
108Renal cell carcinoma_Homo sapiens_hsa052110.65325867
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64355098
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63600681
111Chronic myeloid leukemia_Homo sapiens_hsa052200.63362536
112Histidine metabolism_Homo sapiens_hsa003400.62626189
113Glioma_Homo sapiens_hsa052140.62619637
114Viral carcinogenesis_Homo sapiens_hsa052030.61289490
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61256712
116ECM-receptor interaction_Homo sapiens_hsa045120.61174011
117Synaptic vesicle cycle_Homo sapiens_hsa047210.60955996
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59868269
119Dorso-ventral axis formation_Homo sapiens_hsa043200.59065015
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.57441808
121Endometrial cancer_Homo sapiens_hsa052130.56535994
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56304578
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56125309
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55323720
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55142399
126Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55121911
127Prion diseases_Homo sapiens_hsa050200.54799157
128Choline metabolism in cancer_Homo sapiens_hsa052310.53979843
129Estrogen signaling pathway_Homo sapiens_hsa049150.53910996
130FoxO signaling pathway_Homo sapiens_hsa040680.53720938
131TGF-beta signaling pathway_Homo sapiens_hsa043500.53394644
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53046536
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52200476
134Thyroid cancer_Homo sapiens_hsa052160.51626873
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.51206167
136Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50292055
137Renin secretion_Homo sapiens_hsa049240.48574938
138Thyroid hormone synthesis_Homo sapiens_hsa049180.47796991
139Non-small cell lung cancer_Homo sapiens_hsa052230.47116697
140Proteoglycans in cancer_Homo sapiens_hsa052050.47050360
141Inositol phosphate metabolism_Homo sapiens_hsa005620.46122175
142Neurotrophin signaling pathway_Homo sapiens_hsa047220.45903424
143Adherens junction_Homo sapiens_hsa045200.44880049
144Chemical carcinogenesis_Homo sapiens_hsa052040.44841984
145Shigellosis_Homo sapiens_hsa051310.44612223
146Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44580113
147Galactose metabolism_Homo sapiens_hsa000520.44145860
148African trypanosomiasis_Homo sapiens_hsa051430.43052349
149Systemic lupus erythematosus_Homo sapiens_hsa053220.43005260
150Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42668251
151Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42557850
152Pathways in cancer_Homo sapiens_hsa052000.42553113
153Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42018358
154Focal adhesion_Homo sapiens_hsa045100.41740874
155Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41731180
156Pentose phosphate pathway_Homo sapiens_hsa000300.41367456
157Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41299435
158Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40271090
159Amoebiasis_Homo sapiens_hsa051460.40134549
160Tyrosine metabolism_Homo sapiens_hsa003500.37588048
161Fructose and mannose metabolism_Homo sapiens_hsa000510.37057538
162Pancreatic cancer_Homo sapiens_hsa052120.36285038
163Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29525406
164Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29454017
165Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28181723
166cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28152086
167Small cell lung cancer_Homo sapiens_hsa052220.28074513
168Endocytosis_Homo sapiens_hsa041440.27224190
169Long-term potentiation_Homo sapiens_hsa047200.27047193
170Osteoclast differentiation_Homo sapiens_hsa043800.26185999

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